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Hypercoaguable

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https://www.readbyqxmd.com/read/27487253/thrombelastography-based-dosing-of-enoxaparin-for-thromboprophylaxis-in-trauma-and-surgical-patients-a-randomized-clinical-trial
#1
Christopher R Connelly, Philbert Y Van, Kyle D Hart, Scott G Louis, Kelly A Fair, Anfin S Erickson, Elizabeth A Rick, Erika C Simeon, Eileen M Bulger, Saman Arbabi, John B Holcomb, Laura J Moore, Martin A Schreiber
Importance: Prophylactic enoxaparin is used to prevent venous thromboembolism (VTE) in surgical and trauma patients. However, VTE remains an important source of morbidity and mortality, potentially exacerbated by antithrombin III or anti-Factor Xa deficiencies and missed enoxaparin doses. Recent data suggest that a difference in reaction time (time to initial fibrin formation) greater than 1 minute between heparinase and standard thrombelastogram (TEG) is associated with a decreased risk of VTE...
August 3, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27341308/efficient-quantitative-analysis-of-carboxyalkylpyrrole-ethanolamine-phospholipids-elevated-levels-in-sickle-cell-disease-blood
#2
Junhong Guo, Hua Wang, Borys Hrinczenko, Robert G Salomon
γ-Hydroxy-α,β-unsaturated aldehydes, generated by oxidative damage of polyunsaturated phospholipids, form pyrrole derivatives that incorporate the ethanolamine phospholipid (EP) amino group such as 2-pentylpyrrole (PP)-EP and 2-(ω-carboxyalkyl)pyrrole (CAP)-EP derivatives: 2-(ω-carboxyethyl)pyrrole (CEP)-EP, 2-(ω-carboxypropyl)pyrrole (CPP)-EP, and 2-(ω-carboxyheptyl)pyrrole (CHP)-EP. Because EPs occur in vivo in various forms, a complex mixture of pyrrole-modified EPs with different molecular weights is expected to be generated...
July 18, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27164518/middle-cerebral-artery-stroke-in-a-neonate-with-a-congenital-hypercoagulable-condition-following-repair-of-an-h-type-tracheoesophageal-fistula
#3
Megan L Garcia, Katharine Caldwell, Anna Kellund, Cynthia Reyes
We report a case of middle cerebral artery stroke with heterozygosity for 2 separate hypercoagulable conditions following repair of an H-type tracheoesophageal fistula (TEF) in an infant. Neonatal stroke is rare, occurring in 1 in 4000 births annually in the United States. Stroke after pediatric surgery occurs in approximately 0.05% of patients. Etiologies of stroke in neonates include cardiac, hematologic, vascular, traumatic, metabolic, pharmacologic, infectious, and hypoxemic insults. Thrombophilia has been described in 42% to 78% of neonates with neonatal stroke...
October 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26818643/a-patient-with-factor-v-leiden-and-a-related-pulmonary-embolism
#4
Janet Downs, William A Childers
Venous thromboembolism (VTE) is a complication associated with the hypercoaguable state produced in patients with Factor V Leiden deficiency. Clinically, patients can present with pleuritic chest pain, dyspnea, tachycardia, and unilateral leg swelling, warmth, erythema, and pain. Treatment with heparin is urgent, and patients should continue an anticoagulation drug regimen at home.
February 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/26816965/the-role-of-potentially-retrievable-inferior-vena-cava-filters-in-high-risk-patients-undergoing-joint-arthroplasty
#5
Sabeen Dhand, S David Stulberg, Lalit Puri, Jennifer Karp, Robert K Ryu, Robert J Lewandowski
INTRODUCTION: Some patients undergoing total joint arthroplasty are at increased risk for venous thromboembolism (VTE). The aim of the present study was to evaluate the safety and efficacy of prIVCF in preventing PE in patients undergoing joint replacement surgery who are at high-risk for VTE. MATERIALS AND METHODS: In this prospective, IRB-approved study, prIVCF were placed in consecutive patients who met specific high-risk criteria (history of VTE or hypercoaguable state) prior to total joint arthroplasty...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26683875/intestinal-transplantation-the-anesthesia-perspective
#6
REVIEW
Aparna Dalal
Intestinal transplantation is a complex and challenging surgery. It is very effective for treating intestinal failure, especially for those patients who cannot tolerate parenteral nutrition nor have extensive abdominal disease. Chronic parental nutrition can induce intestinal failure associated liver disease (IFALD). According to United Network for Organ Sharing (UNOS) data, children with intestinal failure affected by liver disease secondary to parenteral nutrition have the highest mortality on a waiting list when compared with all candidates for solid organ transplantation...
April 2016: Transplantation Reviews
https://www.readbyqxmd.com/read/26611775/thromboelastography-in-the-management-of-coagulopathy-associated-with-ebola-virus-disease
#7
Andrew J Wilson, Daniel S Martin, Victoria Maddox, Simon Rattenbury, Davis Bland, Sanjay Bhagani, Ian Cropley, Susan Hopkins, Stephen Mepham, Alison Rodger, Simon Warren, Pratima Chowdary, Michael Jacobs
Here, we describe the first use of thromboelastography (TEG) in the management of 2 cases of Ebola virus disease. Early in their illness, both patients had evidence of a consumptive coagulopathy. As this resolved, TEG demonstrated that both developed a marked hypercoagulable state, which was treated with low-molecular-weight heparin.
March 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26579593/central-retinal-vein-occlusion-in-hereditary-spherocytosis
#8
Alison B Huggins, Sunir J Garg, Ralph S Sando
PURPOSE: To investigate and identify hereditary spherocytosis as a possible risk factor for the development of a central retinal vein occlusion in a young, otherwise healthy, adult. METHOD: This study is a retrospective case description of a single female patient. RESULTS: A 31-year-old white woman with hereditary spherocytosis after splenectomy was found to have a central retinal vein occlusion. She had no atherosclerotic risk factors and a negative hypercoaguable workup...
November 13, 2015: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26525962/switching-from-usual-brand-cigarettes-to-a-tobacco-heating-cigarette-or-snus-part-3-biomarkers-of-biological-effect
#9
RANDOMIZED CONTROLLED TRIAL
Michael W Ogden, Kristin M Marano, Bobbette A Jones, Walter T Morgan, Mitchell F Stiles
A randomized, multi-center study of adult cigarette smokers switched to tobacco-heating cigarettes, snus or ultra-low machine yield tobacco-burning cigarettes (50/group) for 24 weeks was conducted. Evaluation of biomarkers of biological effect (e.g. inflammation, lipids, hypercoaguable state) indicated that the majority of consistent and statistically significant improvements over time within each group were observed in markers of inflammation. Consistent and statistically significant differences in pairwise comparisons between product groups were not observed...
2015: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/26245588/the-characteristics-of-hiv-and-aids-patients-with-deep-vein-thrombosis-at-dr-george-mukhari-academic-hospital
#10
Indiran Govender, Honey L Mabuza, Gboyega A Ogunbanjo
BACKGROUND: Deep vein thrombosis (DVT) is 10 times more prevalent in HIV and AIDS patients than in the general population and is more common in patients with severe immune suppression (CD4 < 200 cells/mL). Opportunistic infections render HIV and AIDS patients susceptible to a hypercoaguable state, including lower protein S levels. AIM AND SETTING: To present the profile of HIV and AIDS patients who developed DVT in the primary care wards of Dr. George Mukhari Academic Hospital (DGMAH), Garankuwa...
2015: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/26194906/thrombolytics-for-late-superior-caval-vein-thrombus-in-a-patient-with-tricuspid-atresia-and-single-lung-glenn-anastomosis
#11
Alexander R Bonnel, Vijayapraveena Paruchuri, Wayne J Franklin
BACKGROUND: Those with cyanotic heart disease have an elevated bleeding risk but also are hypercoaguable. Treating haemodynamically significant thrombi in this unique cohort poses a monumental challenge. Case A 29-year-old women with tricuspid atresia and left pulmonary artery atresia presented with superior caval vein syndrome. She had a right modified Blalock-Taussig shunt as a neonate. A left modified Blalock-Taussig shunt performed later failed to establish flow to her left lung. At age 5, she had a Fontan procedure to the right lung but could not tolerate the physiology and had a low cardiac output syndrome...
January 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/26157944/pylephlebitis-after-colonic-polypectomy-causing-fever-and-abdominal-pain
#12
Zane R Gallinger, Gary May, Paul Kortan, Ahmed M Bayoumi
Pylephlebitis is a rare condition with a high mortality risk if not recognized and treated early. The most common symptoms include fever and abdominal pain, with the majority of cases manifesting with a polymicrobial bacteremia. We report an elderly woman with pylephlebitis presenting with fever, abdominal pain, diarrhea, and vomiting, likely secondary to a polypectomy 6 weeks prior. Abdominal CT revealed portal vein thrombus and blood cultures grew Streptococcus milleri and Haemophilus parainfluenza type V...
April 2015: ACG Case Reports Journal
https://www.readbyqxmd.com/read/26100108/mechanical-heart-valves-in-pregnancy-a-sticky-business
#13
EDITORIAL
Katherine E Economy, Anne Marie Valente
No abstract text is available yet for this article.
July 14, 2015: Circulation
https://www.readbyqxmd.com/read/25328468/bilateral-pulmonary-embolism-in-an-adolescent-with-sickle-cell-disease-and-a-recent-total-hip-arthroplasty-a-case-report-and-review-of-the-literature
#14
REVIEW
Jeremy M Burnham, Marlene Broussard, Todd Milbrandt
Pulmonary embolism is a life-threatening but treatable condition. Factors such as hypercoagulability and recent lower extremity surgery are associated with a higher incidence of thrombus formation and pulmonary embolism. Patients with sickle cell disease have a baseline hypercoaguable state and are at a greater risk forming deep vein thrombosis and pulmonary embolism than the general population. This increased risk is rarely cited in the literature. We describe a sickle cell patient two-weeks status-post total hip arthroplasty who presented with bilateral pulmonary embolism complaining of chest and shoulder pain...
2014: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/25083230/evidence-based-case-report-multiple-thrombotic-episodes-associated-with-lenalidomide-and-dexamethasone-therapy-for-multiple-myeloma
#15
REVIEW
Gordon F Rushworth, Stephen J Leslie, Peter Forsyth, Claire Vincent
Lenalidomide in combination with dexamethasone is a treatment for patients with relapsed or refractory myeloma. Although this combination demonstrates a high level of efficacy, it further exacerbates the hypercoaguable state that exists within myeloma. Thromboprophylactic regimen require careful selection and if warfarin is chosen, assiduous monitoring is required to ensure it will be clinically effective. We report the case of one patient who experienced multiple thrombotic events despite anticoagulant or antiplatelet thromboprophylaxis and review the contributing factors...
June 2012: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/25021002/pmm-05%C3%A2-diagnosis-and-management-of-suspected-venous-thromboembolism-in-pregnancy-experience-in-a-birmingham-maternity-unit
#16
Nk Vanes, H O'Connor, P Baillie, A Sinha
: The hypercoaguable state induced in pregnancy leads to many challenges in clinical management, including an increased risk of venous thromboembolism (VTE). There were 18 deaths in pregnancy attributable to VTE in 2006-2008, reflecting a fall which is attributable to the implementation of national guidelines. A retrospective study was performed assessing whether guidelines were met regarding the initial management of suspected VTE in pregnancy. This included assessment of whether objective testing was performed expeditiously, and whether treatment with low-molecular-weight heparin (LMWH) until the diagnosis was excluded was commenced...
June 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/24984401/acute-ischemic-stroke-in-a-19-month-old-following-minor-head-trauma-case-report-and-review-of-the-literature
#17
REVIEW
Vishnu Garla, Eduardo Pino, Richard Coulon, Rebecca Wolfer
Minor head trauma is a very rare cause of ischemic stroke in the pediatric population. We describe a nineteen month old patient who developed left hemiparesis and subsequently left facial palsy after a fall. MRI of the brain showed hypodensities in the basal ganglia, internal capsule and caudate nucleus consistent with stroke. Echocardiogram and MRA were normal. Hypercoaguable work up showed that the patient was a carrier for a single MTHFR gene. The patient was treated conservatively. On follow up two weeks later his facial palsy had resolved and strength in the extremities improved...
May 2014: West Virginia Medical Journal
https://www.readbyqxmd.com/read/24638277/pulmonary-thromboembolism-a-rare-complication-of-pulmonary-tuberculosis
#18
J Satyasarathi, Arun Gogna, Swapnil Mehta, Jhasaketan Meher
SESSION TITLE: Tuberculosis Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Tuberculosis is one of the most prevalent infectious diseases globally and more so in third world countries like India. There are various systemic manifestation of Tuberculosis however its association with hematological system is rare. Here we are reporting a rare case of Pulmonary thromboembolism associated with tuberculosis. CASE PRESENTATION: A 62 year old female presented with sudden onset shortness of breath,chest pain and swelling in left lower limb...
March 1, 2014: Chest
https://www.readbyqxmd.com/read/24620292/acute-left-sided-numbness-and-weakness-in-a-weightlifter
#19
J Reeser
BACKGROUND: Dietary supplements unregulated by the USFDA carry a risk not only of unintentional doping but of other health disturbances as well. OBJECTIVE: To describe a case of neurological dysfunction following prolonged supplement consumption. DESIGN: Case study. SETTING: Outpatient clinic and tertiary hospital. PATIENT: An 18-yr male with a history of multiple concussions presented with acute progressive left-sided numbness and paresthesias while weight-lifting...
April 2014: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/24516750/thrombophilia-and-recurrent-pregnancy-loss-is-heparin-still-the-drug-of-choice
#20
REVIEW
Adel Abu-Heija
The association between thrombophilia and recurrent pregnancy loss (RPL) has become an undisputed fact. Thorombophilia creates a hypercoaguable state which leads to arterial and/or venous thrombosis at the site of implantation or in the placental blood vessels. Anticoagulants are an effective treatment against RPL in women with acquired thrombophilia due to antiphospholipid syndrome. The results of the use of anticoagulants for treating RPL in women with inherited thrombophilia (IT) are encouraging, but recently four major multicentre studies have shown that fetal outcomes (determined by live birth rates) may not be as favourable as previously suggested...
February 2014: Sultan Qaboos University Medical Journal
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