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https://www.readbyqxmd.com/read/29684613/low-or-excess-levels-of-dietary-cholesterol-impaired-immunity-and-aggravated-inflammation-response-in-young-grass-carp-ctenopharyngodon-idella
#1
Xiao-Zhong Wang, Wei-Dan Jiang, Lin Feng, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Xiao-Qiu Zhou
The present study explored the effect of cholesterol on the immunity and inflammation response in the immune organs (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella) fed graded levels of dietary cholesterol (0.041-1.526%) for 60 days and then infected with Aeromonas hydrophila for 14 days. The results showed that low levels of cholesterol (1) depressed the innate immune components [lysozyme (LZ), acid phosphatase (ACP), complements and antimicrobial peptides] and adaptive immune component [immunoglobulin M (IgM)], (2) up-regulated the mRNA levels of pro-inflammatory cytokines [interleukin 1β (IL-1β), IL-6, IL-8, IL-12p35, IL-12p40, IL-15, IL-17D, tumor necrosis factor α (TNF-α) and interferon γ2 (IFN-γ2)], partly due to the activated nuclear factor kappa B (NF-κB) signalling, and (3) down-regulated the mRNA levels of anti-inflammatory cytokines [IL-4/13B, IL-10, IL-11, transforming growth factor (TGF)-β1 and TGF-β2], partly due to the suppression of target of rapamycin (TOR) signalling in the immune organs of young grass carp...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29662190/autocrine-activation-of-jak2-by-il-11-promotes-platinum-drug-resistance
#2
Wei Zhou, Wei Sun, Mingo M H Yung, Sheng Dai, Yihua Cai, Chi-Wei Chen, Yunxiao Meng, Jennifer B Lee, John C Braisted, Yinghua Xu, Noel T Southall, Paul Shinn, Xuefeng Huang, Zhangfa Song, Xiulei Chen, Yan Kai, Xin Cai, Zongzhu Li, Qiang Hao, Annie N Y Cheung, Hextan Y S Ngan, Stephanie S Liu, Stephanie Barak, Jing Hao, Zhijun Dai, Alexandros Tzatsos, Weiqun Peng, Huadong Pei, Zhiyong Han, David W Chan, Wei Zheng, Wenge Zhu
Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link between ROS and cellular survival pathway is poorly understood. Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29573586/decreased-interleukin-11-levels-in-the-semen-of-infertile-males
#3
Li Qian
The relationship between the interleukin (IL)-11 levels and semen quality of infertile males remains unknown. In this study, 120 semen samples from 60 normozoospermic volunteers and 60 infertile males were examined. The semen pH of the normozoospermic group was not significantly different from that of the infertile group. The semen volume, semen density, forward movement percentage, activity, survival rate and normal morphology rate of the sperm of the infertile group were significantly lower than those of the normozoospermic group...
March 21, 2018: Cytokine
https://www.readbyqxmd.com/read/29557906/autocrine-activation-of-fibroblasts-by-induction-of-il-11-expression-is-a-common-pathway-of-profibrotic-factors
#4
Matthias Mack
No abstract text is available yet for this article.
March 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29555322/increased-interleukin-11-levels-in-thoracic-aorta-and-plasma-from-patients-with-acute-thoracic-aortic-dissection
#5
Yao Xu, Jing Ye, Menglong Wang, Yuan Wang, Qingwei Ji, Ying Huang, Tao Zeng, Zhen Wang, Di Ye, Huimin Jiang, Jianfang Liu, Yingzhong Lin, Jun Wan
BACKGROUND: Interleukin (IL) 11 is closely related to tumor and hematological system diseases. Recent studies have demonstrated that IL-11 also participates in cardiovascular diseases, including ischemia-reperfusion mediated heart injury and acute myocardial infarction. This study aimed to investigate whether IL-11 is involved in acute thoracic aortic dissection (TAD). METHODS: Aortic tissue samples from normal donors and acute TAD patients were collected, and the expression of IL-11 in all aortic tissue was analyzed...
June 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29550807/upregulation-of-il-11-an-il-6-family-cytokine-promotes-tumor-progression-and-correlates-with-poor-prognosis-in-non-small-cell-lung-cancer
#6
Meng Zhao, Yahui Liu, Ran Liu, Jin Qi, Yongwang Hou, Jiao Chang, Li Ren
BACKGROUND/AIMS: Cytokines are key players in tumorigenesis and are potential targets in cancer treatment. Although IL-6 has attracted considerable attention, interleukin 11 (IL-11), another member of the IL-6 family, has long been overlooked, and little is known regarding its specific function in non-small cell lung cancer (NSCLC). In this study, we explored IL-11's role in NSCLC and the detailed mechanism behind it. METHODS: Cell proliferation in response to IL-11 was determined by colony formation, BrdU incorporation and MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay...
March 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29544771/dietary-myo-inositol-deficiency-decreased-intestinal-immune-function-related-to-nf-%C3%AE%C2%BAb-and-tor-signaling-in-the-intestine-of-young-grass-carp-ctenopharyngodon-idella
#7
Shuang-An Li, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Juan Yang, Xu Tang, He-Qun Shi, Xiao-Qiu Zhou
In this study, we investigated the effects of dietary myo-inositol on the intestinal immune barrier function and related signaling pathway in young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp (221.33 ± 0.84 g) were fed six diets containing graded levels of myo-inositol (27.0, 137.9, 286.8, 438.6, 587.7 and 737.3 mg/kg) for 10 weeks. After the growth trial, fish were challenged with Aeromonas hydrophila. The results indicated that compared with the optimal dietary myo-inositol level, myo-inositol deficiency (27...
March 12, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29533934/two-n-linked-glycans-differentially-control-maturation-trafficking-and-proteolysis-but-not-activity-of-the-il-11-receptor
#8
Maria Agthe, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers
BACKGROUND/AIMS: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the IL-11 receptor (IL-11R), and the IL-11/IL-11R complex recruits a homodimer of glycoprotein 130 (gp130). N-linked glycosylation, a post-translational modification where complex oligosaccharides are attached to the side chain of asparagine residues, is often important for stability, folding and biological function of cytokine receptors...
March 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29523682/the-length-of-the-interleukin-11-receptor-stalk-determines-its-capacity-for-classic-signaling
#9
Juliane Lokau, Christoph Garbers
Interleukin (IL)-11 is a multifunctional cytokine that was traditionally recognized for its hematopoietic and anti-inflammatory functions, but has recently been shown also to be involved in tumorigenesis. IL-11 signaling is initiated by binding of the cytokine to the IL-11 receptor (IL-11R), which is not directly involved in signaling, but required for IL-11 binding to the signal-transducing receptor glycoprotein (gp)130. In classic signaling, IL-11 binds to the membrane-bound IL-11R in order to initiate signal transduction...
March 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29503739/regulation-of-osteoclast-differentiation-by-cytokine-networks
#10
REVIEW
Dulshara Sachini Amarasekara, Hyeongseok Yun, Sumi Kim, Nari Lee, Hyunjong Kim, Jaerang Rho
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand play a central role in OC differentiation, which is also termed osteoclastogenesis. Osteoclastogenic cytokines, including tumor necrosis factor-α, IL-1, IL-6, IL-7, IL-8, IL-11, IL-15, IL-17, IL-23, and IL-34, promote OC differentiation, whereas anti-osteoclastogenic cytokines, including interferon (IFN)-α, IFN-β, IFN-γ, IL-3, IL-4, IL-10, IL-12, IL-27, and IL-33, downregulate OC differentiation...
February 2018: Immune Network
https://www.readbyqxmd.com/read/29492387/the-cardioprotective-effect-of-interleukin-11-against-ischemia-reperfusion-injury-in-a-heart-donor-model
#11
Yusaku Tamura, Hiroki Kohno, Tomomi Mohri, Yasushi Fujio, Goro Matsumiya
Background: Previously, we have demonstrated the cardioprotective effect of interleukin (IL)-11 in animal models of acute coronary syndrome. In this study, we sought to evaluate its cardioprotective potential during prolonged hypothermic global ischemia and subsequent reperfusion using a rat heart donor model. Methods: IL-11 was administered intravenously 10 minutes before harvesting the rat heart. The hearts were preserved in cold (4 °C) Krebs-Henseleit buffer for 6 hours, and then attached to a Langendorff perfusion apparatus and reperfused with an oxygenated Krebs-Henseleit solution containing IL-11...
January 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29407773/preclinical-evaluation-of-the-mono-pegylated-recombinant-human-interleukin-11-in-cynomolgus-monkeys
#12
Kuo-Ming Yu, Johnson Yiu-Nam Lau, Manson Fok, Yuk-Keung Yeung, Siu-Ping Fok, Suxing Zhang, Peizhen Ye, Kezhi Zhang, Xiaobo Li, Juan Li, Qin Xu, Wing-Tak Wong, Qui-Lim Choo
The mono-PEGylated recombinant human interleukin-11 (rhIL-11) was evaluated for its pharmacology and toxicology profile in non-human primates. This PEGylated IL-11 (PEG-IL11) showed a much prolonged circulating half-life of 67h in cynomolgus monkeys as compared to its un-PEGylated counterpart (~3h) through subcutaneous administration, implicating that a single injection of the recommended dose will effectively enhance thrombopoiesis in humans for a much longer period of time compared to rhIL-11 in humans (t1/2=6...
February 2, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29381614/bone-conditioned-medium-obtained-from-calvaria-mandible-and-tibia-cause-an-equivalent-tgf-%C3%AE-1-response-in-vitro
#13
Babak Hatami Kia, João Rui Galvão Mendes, Heinz-Dieter Müller, Patrick Heimel, Reinhard Gruber
Bones with different embryological origin and mode of ossification are supposed to vary in their capacity for supporting graft consolidation. The aim of the current pilot study was to assess the TGF-β1 activity of bone chips obtained from distinct anatomic locations. Conditioned medium was prepared from bone chips harvested from pig calvaria, mandible, and tibia. Human oral fibroblasts were exposed to bone-conditioned medium (BCM) followed by reverse transcriptase polymerase chain reaction of the TGF-β1 target genes...
January 19, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29361454/interleukin-11-blockade-during-mid-to-late-gestation-does-not-affect-maternal-blood-pressure-pregnancy-viability-or-subsequent-fertility-in-mice
#14
Amy Winship, Ellen Menkhorst, Michelle Van Sinderen, Evdokia Dimitriadis
Interleukin (IL)11 is a crucial regulator during the initiation of pregnancy in humans and mice. Elevated levels are detected in serum, placenta and decidua of women with pre-eclampsia. Elevated IL11 during placentation recapitulates pre-eclampsia in mice, although withdrawal rescues pre-eclampsia features, suggesting that IL11 could provide a novel therapeutic target. The aim of this study was to determine the safety profile of an IL11 antagonist ligated to polyethylene glycol (PEGIL11A) during pregnancy in mice...
March 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29345808/immune-protective-effects-of-chitooligosaccharides-on-mice-genital-tract-infected-by-chlamydia-trachomatis
#15
Li Qian, Linjun Chen
PROBLEM: The immune protective effects of chitooligosaccharides (COs) on mouse genital tract infected by Chlamydia trachomatis (Ct) were unknown. METHODS: The minimum effective/infective dose was obtained by establishing the murine model of the genital tract infected by Ct. The model mice were treated with different doses (0.1, 0.2, and 0.3 g/kg,) of COs and 0.9% saline, and the serum immunoglobulin G (IgG) antibody and interleukin (IL)-11 levels were then assayed...
January 18, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29343249/microrna-124-inhibits-bone-metastasis-of-breast-cancer-by-repressing-interleukin-11
#16
Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan, Jian-Ru Xiao
BACKGROUND: Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event in the metastases of breast cancer to bone. microRNA-124 (miR-124) has been proved to inhibit cancer progression, whereas its effect on bone metastases of breast cancer has not been reported. Therefore, this study aimed to investigate the role and underlying mechanism of miR-124 in bone metastases of breast cancer...
January 17, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29331759/astragaloside-iv-inhibits-cell-migration-and-viability-of-hepatocellular-carcinoma-cells-via-suppressing-long-noncoding-rna-atb
#17
Yaling Li, Yun Ye, Hongyan Chen
Astragaloside IV (AS-IV), the major active component of Astragalus membranaceus, has shown attractive anticancer effects in certain cancers. However, the roles and action mechanisms of AS-IV in hepatocellular carcinoma (HCC) are largely unclear. Long noncoding RNAs (lncRNAs) are recently revealed to have crucial roles in HCC initiation and progression, but whether lncRNAs participate in the anticancer roles of AS-IV are unknown. In this study, we demonstrated that AS-IV significantly downregulated lncRNA-ATB expression in a dose- and time-dependent manner in HCC cells...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29327326/il-11-facilitates-a-novel-connection-between-ra-joint-fibroblasts-and-endothelial-cells
#18
Hatem A Elshabrawy, Michael V Volin, Abdul B Essani, Zhenlong Chen, Iain B McInnes, Katrien Van Raemdonck, Karol Palasiewicz, Shiva Arami, Mark Gonzalez, Hossam M Ashour, Seung-Jae Kim, Guofei Zhou, David A Fox, Shiva Shahrara
IL-11 has been detected in inflamed joints; however, its role in the pathogenesis of arthritis is not yet clear. Studies were conducted to characterize the expression and functional significance of IL-11 and IL-11Rα in rheumatoid arthritis (RA). IL-11 levels were elevated in RA synovial fluid (SF) compared to osteoarthritis (OA) SF and plasma from RA, OA and normal individuals (NLs). Morphologic studies established that IL-11 was detected in lining fibroblasts and macrophages in addition to sublining endothelial cells and macrophages at higher levels in RA compared to NL synovial tissues...
May 2018: Angiogenesis
https://www.readbyqxmd.com/read/29286137/microrna-124a-inhibits-cell-proliferation-and-migration-in-liver-cancer-by-regulating-interleukin-11
#19
Liedao Yu, Shuo Wang, Xiangjin Lin, Yang Lu, Pengcheng Gu
Liver cancer is the sixth most common malignant tumour and ranks in the top three cancers with regard to mortality due to metastasis and postsurgical recurrence. It is significant to understand the mechanisms underlying liver cancer for diagnosis and treatment. Cumulative evidence suggests that the abnormal regulation of microRNAs (miRNAs/miRs) may contribute to the development and metastasis of cancer. miR‑124a acts as a tumour suppressor in osteosarcoma, endometrial carcinoma, prostate cancer, and glioblastoma...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29279421/-bone-derived-hormones-and-their-systemic-regulation
#20
Yuichi Takashi, Seiji Fukumoto, Toshio Matsumoto
Bone has several functions such as supporting our body, protecting internal organs and contributing to hematopoiesis. Recently, it has been revealed that bone also works as an endocrine tissue and systemically regulates functions of other organs. It has been reported that fibroblast growth factor 23(FGF23)regulates phosphate metabolism and osteocalcin affect glucose/energy metabolism. In addition, sclerostin, interleukin-11(IL-11)and lipocalin 2 have been also found to be bone-derived humoral factors. Further investigation concerning the network systems among multiple organs via bone-derived hormones may lead to the development of new drugs...
2018: Clinical Calcium
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