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https://www.readbyqxmd.com/read/29217821/il-11-promotes-the-treatment-efficacy-of-hematopoietic-stem-cell-transplant-therapy-in-aplastic-anemia-model-mice-through-a-nf-%C3%AE%C2%BAb-microrna-204-thrombopoietin-regulatory-axis
#1
Yan Wang, Zhi-Yun Niu, Yu-Jie Guo, Li-Hua Wang, Feng-Ru Lin, Jing-Yu Zhang
Hematopoietic stem cell (HSC) transplantation could be of therapeutic value for aplastic anemia (AA) patients, and immunosuppressants may facilitate the efficiency of the procedure. As anti-inflammatory cytokine interleukin-11 (IL-11) has a thrombopoietic effect, its use in cases of chronic bone marrow failure, such as AA, has been proposed to induce HSC function. However, the putative mechanisms that may support this process remain poorly defined. We found that decreased miR-204-5p levels were coincident with increased proliferation in mouse HSCs following exposure to IL-11 in vitro...
December 8, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29202476/stromal-lkb1-deficiency-leads-to-gastrointestinal-tumorigenesis-involving-the-il-11-jak-stat3-pathway
#2
Saara Ollila, Eva Domènech-Moreno, Kaisa Laajanen, Iris Pl Wong, Sushil Tripathi, Nalle Pentinmikko, Yajing Gao, Yan Yan, Elina H Niemelä, Timothy C Wang, Benoit Viollet, Gustavo Leone, Pekka Katajisto, Kari Vaahtomeri, Tomi P Mäkelä
Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse models; however, the cell types and signaling pathways underlying tumor formation are unknown. Here, we demonstrated that mesenchymal progenitor- or stromal fibroblast-specific deletion of Lkb1 results in fully penetrant polyposis in mice. Lineage tracing and immunohistochemical analyses revealed clonal expansion of Lkb1-deficient myofibroblast-like cell foci in the tumor stroma...
December 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29188810/cardioprotection-il-11-is-a-potential-therapeutic-target-in-cardiovascular-fibrosis
#3
Irene Fernández-Ruiz
No abstract text is available yet for this article.
November 30, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29136368/split-2-protein-ligation-generates-active-il-6-type-hyper-cytokines-from-inactive-precursors
#4
Jens Mark Moll, Melanie Wehmöller, Nils Christopher Frank, Lisa Homey, Paul Baran, Christoph Garbers, Larissa Lamertz, Jonathan H Axelrod, Eithan Galun, Henning D Mootz, Jürgen Scheller
Trans-signaling of the major pro- and anti-inflammatory cytokines Interleukin (IL)-6 and IL-11 has the unique feature to virtually activate all cells of the body and is critically involved in chronic inflammation and regeneration. Hyper-IL-6 and Hyper-IL-11 are single chain designer trans-signaling cytokines, in which the cytokine and soluble receptor units are trapped in one complex via a flexible peptide linker. Albeit, Hyper-cytokines are essential tools to study trans-signaling in vitro and in vivo, the superior potency of these designer cytokines are accompanied by undesirable stress responses...
November 14, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29113344/polysaccharides-from-chrysanthemum-morifolium-ramat-ameliorate-colitis-rats-by-modulating-the-intestinal-microbiota-community
#5
Jin-Hua Tao, Jin-Ao Duan, Shu Jiang, Nan-Nan Feng, Wen-Qian Qiu, Yong Ling
The gut microflora dysbiosis has been closely related with the inflammatory bowel disease (IBD). In this study, the effect of polysaccharides from Chrysanthemum morifolium Ramat on the gut microbiota was evaluated by ulcerative colitis (UC) rat model. Physiological and pathological analyses suggested that Chrysanthemum polysaccharides possessed notably protective effects on UC in vivo. Based on the Illumina MiSeq platform, 16S rRNA sequencing of the rat colonic contents indicated that the intestinal flora structure remarkably changed in the model rats and the tendency was alleviated to a certain degree by treatment with different dosages of Chrysanthemum polysaccharides...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100303/krt8-upregulation-promotes-tumor-metastasis-and-is-predictive-of-a-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#6
Hai-Song Tan, Wei-Hua Jiang, Yi He, De-Sheng Wang, Zhen-Jie Wu, Deng-Shuang Wu, Li Gao, Yi Bao, Jia-Zi Shi, Bing Liu, Li-Jun Ma, Lin-Hui Wang
Keratin 8 (KRT8) plays an essential role in the development and metastasis of multiple human cancers. However, its role in clear cell renal cell carcinoma (ccRCC) remains unexplored. Here, we investigated the expression pattern, clinical significance, and function of KRT8 in ccRCC. KRT8 mRNA and protein levels were determined in two large cohorts using quantitative real-time polymerase chain reaction (qRT-PCR) and tissue microarray (TMA) immunohistochemistry (IHC), respectively. We found that KRT8 expression was upregulated in ccRCC and vein tumor thrombi (VTTs)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098000/pro-inflammatory-state-in-monoclonal-gammopathy-of-undetermined-significance-and-in-multiple-myeloma-is-characterized-by-low-sialylation-of-pathogen-specific-and-other-monoclonal-immunoglobulins
#7
Adrien Bosseboeuf, Sophie Allain-Maillet, Nicolas Mennesson, Anne Tallet, Cédric Rossi, Laurent Garderet, Denis Caillot, Philippe Moreau, Eric Piver, François Girodon, Hélène Perreault, Sophie Brouard, Arnaud Nicot, Edith Bigot-Corbel, Sylvie Hermouet, Jean Harb
Multiple myeloma (MM) and its pre-cancerous stage monoclonal gammopathy of undetermined significance (MGUS) allow to study immune responses and the chronology of inflammation in the context of blood malignancies. Both diseases are characterized by the production of a monoclonal immunoglobulin (mc Ig) which for subsets of MGUS and MM patients targets pathogens known to cause latent infection, a major cause of inflammation. Inflammation may influence the structure of both polyclonal (pc) Ig and mc Ig produced by malignant plasma cells via the sialylation of Ig Fc fragment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29070131/-efficacy-of-shengxue-mixture-combined-with-intraosseous-infusion-for-treatment-of-aplastic-anemia
#8
Shan-Xi Liu, Yi-Guo Liu, Peng-Hui Wang, Mao-Feng Qi, Meng Luo
OBJECTIVE: To evaluate the efficacy and safety of Shengxue mixture combined with intraosseous blood infusion for treatment of aplastic anemia patients. METHODS: From 2011 to 2015, Institute of blood diseases of Shaanxi Medical University admitted 53 patients with aplastic anemia. The patients were treated with shengxue mixture 200 ml, orally, twice a day. Stanozolol tablets, Adult 2 mg, three times a day, mycophenolate mofetil 1.0 g, twice a day. Intraosseous infusion of the following medicine were administered in patients: recombinant human EPO 10000 U, recombinant human G-CSF 450 µg, recombinant human IL-11 4...
October 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29032197/interleukin-22-attenuates-double-stranded-rna-induced-upregulation-of-pd-l1-in-airway-epithelial-cells-via-a-stat3-dependent-mechanism
#9
Nanae Seki, Keiko Kan-O, Koichiro Matsumoto, Satoru Fukuyama, Saaka Hamano, Ken Tonai, Keiichi Ota, Hiromasa Inoue, Yoichi Nakanishi
Double-stranded RNA derived from viruses induces host immune responses. PD-L1, also known as B7-H1, is an immune-checkpoint molecule associated with the escape of viruses from host immune systems, which plays a role in the persistence of viral infection, resulting in exacerbations of underlying diseases such as asthma and chronic obstructive pulmonary disease. Interleukin (IL)-22 is produced from various immune cells and has protective properties on mucosal tissue. The binding of IL-22 to IL-22 receptor induces STAT3 activation...
October 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28960674/requisite-role-of-vasohibin-2-in-spontaneous-gastric-cancer-formation-and-accumulation-of-cancer-associated-fibroblasts
#10
Yasuhiro Suzuki, Shuji Kitahara, Takuya Suematsu, Masanobu Oshima, Yasufumi Sato
The vasohibin (VASH) family consists of two genes, VASH1 and VASH2. VASH1 is mainly expressed in vascular endothelial cells and suppresses angiogenesis in an autocrine manner, whereas VASH2 is mainly expressed in cancer cells and exhibits pro-angiogenic activity. Employing adenomatous polyposis coli gene mutant mice, we recently reported on the role of Vash2 in the spontaneous formation of intestinal tumors. In this study, we used K19-Wnt1/C2mE (Gan) mice and examined the role of Vash2 in spontaneous gastric cancer formation...
September 27, 2017: Cancer Science
https://www.readbyqxmd.com/read/28951222/dietary-pyridoxine-deficiency-reduced-growth-performance-and-impaired-intestinal-immune-function-associated-with-tor-and-nf-%C3%AE%C2%BAb-signalling-of-young-grass-carp-ctenopharyngodon-idella
#11
Xin Zheng, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
The objective of this study was to evaluate the effects of dietary pyridoxine (PN) deficiency on growth performance, intestinal immune function and the potential regulation mechanisms in young grass carp (Ctenopharyngodon idella). Fish were fed six diets containing graded levels of PN (0.12-7.48 mg/kg) for 70 days. After that, a challenge test was conducted by infection of Aeromonas hydrophila for 14 days. The results showed that compared with the optimal PN level, PN deficiency: (1) reduced the production of innate immune components such as lysozyme (LZ), acid phosphatase (ACP), complements and antimicrobial peptides and adaptive immune components such as immunoglobulins in three intestinal segments of young grass carp (P < 0...
September 23, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28922655/zymosan-a-protects-the-hematopoietic-system-from-radiation-induced-damage-by-targeting-tlr2-signaling-pathway
#12
Jicong Du, Ying Cheng, Suhe Dong, Pei Zhang, Jiaming Guo, Jiaqi Han, Fu Gao, Hainan Zhao, Ding Sun, Jianguo Cui, Jianming Cai, Cong Liu
BACKGROUND/AIMS: The hematopoietic system is vulnerable to ionizing radiation and is often severely damaged by radiation. Molecules affecting radioresistance include Toll-like receptor 2. We investigated whether Zymosan-A, a novel TLR2 agonist, can protect the hematopoietic system from radiation-induced damage after total body irradiation. METHODS: Mice were exposed to total body radiation after treatment with Zymosan-A or normal saline, and their survival was recorded...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28887447/interleukin-11-induces-and-maintains-progenitors-of-different-cell-lineages-during-xenopus-tadpole-tail-regeneration
#13
Hiroshi Tsujioka, Takekazu Kunieda, Yuki Katou, Katsuhiko Shirahige, Taro Fukazawa, Takeo Kubo
Unlike mammals, Xenopus laevis tadpoles possess high ability to regenerate their lost organs. In amphibians, the main source of regenerated tissues is lineage-restricted tissue stem cells, but the mechanisms underlying induction, maintenance and differentiation of these stem/progenitor cells in the regenerating organs are poorly understood. We previously reported that interleukin-11 (il-11) is highly expressed in the proliferating cells of regenerating Xenopus tadpole tails. Here, we show that il-11 knockdown (KD) shortens the regenerated tail length, and the phenotype is rescued by forced-il-11-expression in the KD tadpoles...
September 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28864002/interleukin-11-classic-but-not-trans-signaling-is-essential-for-fertility-in-mice
#14
Maria Agthe, Yvonne Garbers, Tracy Putoczki, Christoph Garbers
The cytokine interleukin (IL)-11 activates its target cells through binding to the membrane-bound IL-11 receptor (IL-11R). Female mice deficient in IL-11R (Il11ra(-/-)) are infertile due to a defect in decidualization when the blastocyst implants. We have recently shown that IL-11 can also signal via a soluble IL-11R (trans-signaling). Which IL-11 pathway is required for fertility in mice is unknown. We confirm that female Il11ra(-/-)mice, lacking both classic and trans-signaling, are infertile. In contrast, the selective blockade of IL-11 trans-signaling does not affect fertility in mice...
September 2017: Placenta
https://www.readbyqxmd.com/read/28861713/lncrna-zeb1-as1-contributes-to-stat3-activation-by-associating-with-il-11-in-b-lymphoblastic-leukemia
#15
Qing Wang, Xiaoli Du, Min Yang, Shishan Xiao, Jun Cao, Jun Song, Linhui Wang
OBJECTIVE: To investigate the role of lncRNA ZEB1-AS1 in B-lineage acute lymphoblastic leukemia (B-ALL). RESULTS: ZEB1-AS1 levels were aberrantly up-regulated in B-ALL. All correlated with STAT3 activation and IL-11 production. Moreover, a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. Mechanistically, ZEB1-AS1 could bind to IL-11 and promote IL-11 stability. Down-regulation of ZEB1-AS1 decreased IL-11 production of human bone marrow stromal cells (BMSCs), which led to suppressed proliferation and inhibited IL-11/STAT3 pathway in BALL-1 cells...
August 31, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28854223/therapeutic-potential-of-tonsil-derived-mesenchymal-stem-cells-in-dextran-sulfate-sodium-induced-experimental-murine-colitis
#16
Yeonsil Yu, Eun Mi Song, Ko Eun Lee, Yang-Hee Joo, Seong-Eun Kim, Chang Mo Moon, Ha Yeong Kim, Sung-Ae Jung, Inho Jo
The therapeutic potential of tonsil-derived mesenchymal stem cells (TMSC) prepared from human tonsillar tissue has been studied in animal models for several diseases such as hepatic injury, hypoparathyroidism, diabetes and muscle dystrophy. In this study, we examined the therapeutic effects of TMSC in a dextran sulfate sodium (DSS)-induced colitis model. TMSC were injected in DSS-induced colitis mice via intraperitoneal injection twice (TMSC[x2]) or four times (TMSC[x4]). Control mice were injected with either phosphate-buffered saline or human embryonic kidney 293 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28748627/genetic-ablation-of-carbonic-anhydrase-ix-disrupts-gastric-barrier-function-via-claudin-18-downregulation-and-acid-backflux
#17
T Li, X Liu, B Riederer, K Nikolovska, A K Singh, K A Mäkelä, A Seidler, Y Liu, G Gros, H Bartels, K H Herzig, U Seidler
AIM: This study aimed to explore the molecular mechanisms for the parietal cell loss and fundic hyperplasia observed in gastric mucosa of mice lacking the carbonic anhydrase 9 (CAIX). METHODS: We assessed the ability of CAIX-knockout and WT gastric surface epithelial cells to withstand a luminal acid load by measuring the pHi of exteriorized gastric mucosa in vivo using two-photon confocal laser scanning microscopy. Cytokines and claudin-18A2 expression was analysed by RT-PCR...
July 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28747553/krt8-upregulation-promotes-tumor-metastasis-and-is-predictive-of-a-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#18
Hai-Song Tan, Wei-Hua Jiang, Yi He, De-Sheng Wang, Zhen-Jie Wu, Deng-Shuang Wu, Li Gao, Yi Bao, Jia-Zi Shi, Bing Liu, Li-Jun Ma, Lin-Hui Wang
Keratin 8 (KRT8) plays an essential role in the development and metastasis of multiple human cancers. However, its role in clear cell renal cell carcinoma (ccRCC) remains unexplored. Here, we investigated the expression pattern, clinical significance, and function of KRT8 in ccRCC. KRT8 mRNA and protein levels were determined in two large cohorts using quantitative real-time polymerase chain reaction (qRT-PCR) and tissue microarray (TMA) immunohistochemistry (IHC), respectively. We found that KRT8 expression was upregulated in ccRCC and vein tumor thrombi (VTTs)...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747427/a-biallelic-mutation-in-il6st-encoding-the-gp130-co-receptor-causes-immunodeficiency-and-craniosynostosis
#19
Tobias Schwerd, Stephen R F Twigg, Dominik Aschenbrenner, Santiago Manrique, Kerry A Miller, Indira B Taylor, Melania Capitani, Simon J McGowan, Elizabeth Sweeney, Astrid Weber, Liye Chen, Paul Bowness, Andrew Riordan, Andrew Cant, Alexandra F Freeman, Joshua D Milner, Steven M Holland, Natalie Frede, Miryam Müller, Dirk Schmidt-Arras, Bodo Grimbacher, Steven A Wall, E Yvonne Jones, Andrew O M Wilkie, Holm H Uhlig
Multiple cytokines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory factor (LIF), signal via the common GP130 cytokine receptor subunit. In this study, we describe a patient with a homozygous mutation of IL6ST (encoding GP130 p.N404Y) who presented with recurrent infections, eczema, bronchiectasis, high IgE, eosinophilia, defective B cell memory, and an impaired acute-phase response, as well as skeletal abnormalities including craniosynostosis. The p.N404Y missense substitution is associated with loss of IL-6, IL-11, IL-27, and OSM signaling but a largely intact LIF response...
September 4, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28735867/cleavage-of-the-interleukin-11-receptor-induces-processing-of-its-c-terminal-fragments-by-the-gamma-secretase-and-the-proteasome
#20
Juliane Lokau, Charlotte M Flynn, Christoph Garbers
The cytokine Interleukin-11 (IL-11) signals through the membrane-bound IL-11 receptor (IL-11R), which is expressed in a cell-type specific manner. We have recently shown that the metalloprotease ADAM10 can cleave the IL-11R. The liberated soluble IL-11R (sIL-11R) ectodomain can bind its ligand, and the resulting IL-11/sIL-11R complex can activate cells that do not express the IL-11R (trans-signaling). In this study, we show that the remaining C-terminal fragment (CTF1) after ADAM10-mediated cleavage is subsequently cleaved within the membrane by the gamma-secretase complex, and that the resulting shorter CTF2 is further degraded by the proteasome...
September 16, 2017: Biochemical and Biophysical Research Communications
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