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https://www.readbyqxmd.com/read/27922075/cancer-associated-fibroblasts-treated-with-cisplatin-facilitates-chemoresistance-of-lung-adenocarcinoma-through-il-11-il-11r-stat3-signaling-pathway
#1
Leilei Tao, Guichun Huang, Rui Wang, Yan Pan, Zhenyue He, Xiaoyuan Chu, Haizhu Song, Longbang Chen
Cancer-associated fibroblasts (CAF) are recognized as one of the key determinants in the malignant progression of lung adenocarcinoma. And its contributions to chemoresistance acquisition of lung cancer has raised more and more attention. In our study, cancer associated fibroblasts treated with cisplatin conferred chemoresistance to lung cancer cells. Meanwhile, Interleukin-11(IL-11) was significantly up-regulated in the CAF stimulated by cisplatin. As confirmed in lung adenocarcinoma cells in vivo and in vitro, IL-11 could protect cancer cells from cisplatin-induced apoptosis and thus promote their chemoresistance...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916836/expression-purification-and-characterization-of-interleukin-11-orthologues
#2
Andrei S Sokolov, Alexei S Kazakov, Valery V Solovyev, Ramis G Ismailov, Vladimir N Uversky, Yulia S Lapteva, Roman V Mikhailov, Ekaterina V Pavlova, Iana O Terletskaya, Ludmila V Ermolina, Sergei E Permyakov, Eugene A Permyakov
Interleukin-11 (IL-11) is a multifunctional cytokine implicated in several normal and pathological processes. The decoding of IL-11 function and development of IL-11-targeted drugs dictate the use of laboratory animals and need of the better understanding of species specificity of IL-11 signaling. Here, we present a method for the recombinant interleukin-11 (rIL-11) production from the important model animals, mouse and macaque. The purified mouse and macaque rIL-11 interact with extracellular domain of human IL-11 receptor subunit α and activate STAT3 signaling in HEK293 cells co-expressing human IL-11 receptors with efficacies resembling those of human rIL-11...
November 29, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27901021/tmed3-promotes-hepatocellular-carcinoma-progression-via-il-11-stat3-signaling
#3
Hao Zheng, Yuan Yang, Jun Han, Wei-Hua Jiang, Cheng Chen, Meng-Chao Wang, Rong Gao, Shuai Li, Tao Tian, Jian Wang, Li-Jun Ma, Hao Ren, Wei-Ping Zhou
Transmembrane p24 trafficking protein 3(TMED3) is a metastatic suppressor in colon cancer, but its function in the progression of hepatocellular carcinoma (HCC) is unknown. Here, we report that TMED3 was up-regulated in HCC and portal vein tumor thrombus. TMED3 up-regulation in HCC was significantly correlated with aggressive characteristics and predicted poor prognosis in HCC patients. TMED3 overexpression in HCC cell lines promoted cell migration and invasion. In contrast, TMED3 knockdown suppressed HCC metastasis both in vitro and in vivo...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27885183/-osteoporosis-and-mechano-biosciences
#4
Toshio Matsumoto
Mechanical unloading due to long-term bedrest or microgravity during spaceflight causes a devastating influence on bone. Although bisphosphonates can prevent bone loss and hypercalciuria by mechanical unloading for up to 6 months, the influence of unloading for longer period of time is unknown. This is because mechanical loading is one of the most important stimuli for bone formation. Mechanical stress activates several intracellular signaling pathways. Among them, activation of stress-activated cation channel by fluid shear stress stimulates ERK-CREB signaling to enhance the expression of fos family transcription factors, which stimulates IL-11 expression in osteoblastic cells...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27884519/production-and-characterization-of-genetically-modified-human-il-11-variants
#5
Emiko Sano, Toshiaki Takei, Takuya Ueda, Kouhei Tsumoto
Interleukin-11 (IL-11) has been expected as a drug on severe thrombocytopenia caused by myelo-suppressive chemotherapy. Whereas, development of IL-11 inhibitor is also expected for a treatment against IL-11 related cancer progression. Here, we will demonstrate the creation of various kinds of genetically modified hIL-11s. Modified vectors were constructed by introducing N- or O-glycosylation site on the region of hIL-11 that does not belong to the core α-helical motif based on the predicted secondary structure...
November 22, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27878687/aptamers-against-pro-and-anti-inflammatory-cytokines-a-review
#6
REVIEW
Maryam Boshtam, Seddigheh Asgary, Shirin Kouhpayeh, Laleh Shariati, Hossein Khanahmad
Inflammatory disorders result from continuous inflammation in injured sites. Many molecules are involved in this process; the inhibition of which could prevent the inflammation. Chemokines are a group of these biological mediators which are categorized into pro-, anti-, and pro-/anti-inflammatory. Thus, targeting these essential molecules can be an effective way for prevention and control of inflammatory diseases. Various therapeutic agents have been developed for primary and secondary prevention of these disorders, but each of them has its own limitations...
November 23, 2016: Inflammation
https://www.readbyqxmd.com/read/27872193/critical-contribution-of-nuclear-factor-erythroid-2-related-factor-2-nrf2-to-electrophile-induced-interleukin-11-production
#7
Takashi Nishina, Yutaka Deguchi, Ryosuke Miura, Soh Yamazaki, Yasuhiro Shinkai, Yuko Kojima, Ko Okumura, Yoshito Kumagai, Hiroyasu Nakano
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a crucial role in protection of cells from electrophile-induced toxicity through upregulating phase II detoxifying enzymes and phase III transporters. We previously reported that oxidative stress induces upregulation of interleukin-11 (IL-11), a member of the IL-6 family that ameliorates acetaminophen-induced liver toxicity. However, a role for IL-11 in protection of cells from electrophile-induced toxicity remains unclear...
November 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27784384/-thrombocytopoietic-efficacy-of-pegylated-recombinant-human-interleukin-11-mutein-in-myelosuppressed-mice
#8
Shan-Shan Ma, Seong-Hyun Ho, Hong-Ling Wang, Li-Ya Nie, Song-Shan Xu
OBJECTIVE: To evaluate the effect of PEGylated IL-11 mutein (PEG-mIL 11) with different dose or injection frequency on thrombocytopenia in myelosuppressed mice and to compare its effect with mIL-11, so as to provide reference data for clinical use. METHODS: Myelosuppressive model with thrombocyopenia was produced in BALB/c mice by whole body (60)Co γ-ray irradiation in dose of administration 2.5 Gy followed by i.p. injections of carboplatin at 50 mg/kg. In study of injection frequency, 30 thrombocytopenic BALB/c mice were randomly divided into 5 groups: vehicle control group (once daily on d1, 4, 7), mIL-11 group [200 µg/(kg·d)×9 d], PEG-mIL 11 A group [111800 µg/(kg·d)×1 d (d 1)], PEG-mIL 11 B group 900 µg/(kg·d)×2 d (d 1,5), and PEG-mIL 11 C group [600 µg/(kg·d)×3 d (d 1,4,7)]...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27750106/breast-cancer-osteomimicry-and-its-role-in-bone-specific-metastasis-an%C3%A2-integrative-systematic-review-of-preclinical-evidence
#9
REVIEW
Olugbenga Awolaran, Susan A Brooks, Verna Lavender
Metastasis accounts for most of the deaths from breast cancer and the preference of invasive breast cancer metastasising to bone has been widely reported. However, the biological basis of breast cancer osteotropism is not fully understood. This paper provides, for the first time, an integrative, systematic review of evidence of molecular factors that have functional roles in the homing of metastatic breast cancer to the bone. Pubmed, Web of Science and EBSCOhost were searched using keywords and synonyms for molecular, metastasis, breast cancer and bone to identify articles published between January 2004 and August 2016...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27746864/repairing-effects-of-interleukin-11-il-11-towards-high-dose-methotrexate-induced-rat-small-intestinal-mucositis-and-its-impacts-on-t-lymphoblastic-leukemia-cell-line
#10
Yueqin Han, Yanping Zhu, Jinshen Wang, Yanqin Han, Daogang Qin, Qiaozhi Yang, Xiaojing Sun, Lijun Chen
OBJECTIVES: To investigate the efficacy of interleukin 11 (IL-11) towards the high dose methotrexate (HDMTX)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human T-lymphoblastic leukemia (CEM) cell line. MATERIALS AND METHODS: 95 Wistar rats were randomly divided into five groups, the normal control group (A), the methotrexate (MTX) control group (B), the IL-11-pre-treated high-dose group (C), the post-IL-11-treatment high-dose group (D) and the post-IL-11-treatment low-dose group (E)...
August 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27693781/inorganic-polyphosphate-triggers-upregulation-of-interleukin-11-in-human-osteoblast-like-saos-2-cells
#11
Eric Lik-Hang Lui, Carl Ka-Leong Ao, Lina Li, Mei-Li Khong, Julian Alexander Tanner
Polyphosphate (polyP) is abundant in bone but its roles in signaling and control of gene expression remain unclear. Here, we investigate the effect of extracellular polyP on proliferation, migration, apoptosis, gene and protein expression in human osteoblast-like SaOS-2 cells. Extracellular polyP promoted SaOS-2 cell proliferation, increased rates of migration, inhibited apoptosis and stimulated the rapid phosphorylation of extracellular-signal-regulated kinase (ERK) directly through basic fibroblast growth factor receptor (bFGFR)...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27677834/frontline-science-human-bone-cells-as-a-source-of-il-27-under-inflammatory-conditions-role-of-tlrs-and-cytokines
#12
Frédérique Larousserie, Laura Bsiri, Valérie Dumaine, Céline Dietrich, Anne Audebourg, Brigitte Radenen-Bussière, Philippe Anract, Marie-Cécile Vacher-Lavenu, Odile Devergne
IL-27 regulates immune responses as well as hematopoiesis and bone remodeling, but its cellular sources in the bone remain unknown. In this study, we investigated whether osteoclasts and osteoblasts-the 2 cell types orchestrating bone homeostasis-could be a source of IL-27 and identified stimuli that induce its expression in vitro. We observed that human monocyte-derived osteoclasts expressed a broader range of TLRs than did human primary osteoblasts and that both cell types exhibited a differential induction of IL-27 expression in response to TLR or cytokine stimulation...
September 27, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27640333/dietary-vitamin-c-deficiency-depressed-the-gill-physical-barriers-and-immune-barriers-referring-to-nrf2-apoptosis-mlck-nf-%C3%AE%C2%BAb-and-tor-signaling-in-grass-carp-ctenopharyngodon-idella-under-infection-of-flavobacterium-columnare
#13
Hui-Jun Xu, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study explored the effects of vitamin C on the physical barriers and immune barriers, and relative mRNA levels of signaling molecules in the gill of grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare. The results indicated that compared with optimal vitamin C supplementation, vitamin C deficiency (2.9 mg/kg diet) (1) increased reactive oxygen species, malondialdehyde and protein carbonyl (PC) contents (P < 0.05), decreased the copper/zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and mRNA levels (P < 0...
September 15, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27635197/repairing-effects-of-interleukin-11-il-11-towards-high-dose-methotrexate-induced-rat-small-intestinal-mucositis-and-its-impacts-on-t-lymphoblastic-leukemia-cell-line
#14
Yueqin Han, Yanping Zhu, Jinshen Wang, Yanqin Han, Daogang Qin, Qiaozhi Yang, Xiaojing Sun, Lijun Chen
OBJECTIVES: To investigate the efficacy of interleukin 11 (IL-11) towards the high dose methotrexate (HDMTX)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human T-lymphoblastic leukemia (CEM) cell line. MATERIALS AND METHODS: 95 Wistar rats were randomly divided into five groups, the normal control group (A), the methotrexate (MTX) control group (B), the IL-11-pre-treated high-dose group (C), the post-IL-11-treatment high-dose group (D) and the post-IL-11-treatment low-dose group (E)...
July 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27539014/enhanced-hematopoietic-stem-cell-self-renewal-promoting-ability-of-clonal-primary-mesenchymal-stromal-stem-cells-versus-their-osteogenic-progeny
#15
Qiling He, Claude Scott Swindle, Chao Wan, Robert J Flynn, Robert A Oster, Dongquan Chen, Fengjie Zhang, Yinglan Shu, Christopher A Klug
Long-term self-renewing hematopoietic stem cell (LT-HSC) homeostasis within the bone marrow (BM) of adult mammals is regulated by complex interactions between LT-HSC and a number of niche-associated cell types including mesenchymal stromal/stem cells (MSC), osteoblasts (OB), macrophage, and neuronal cells in close proximity with the vasculature. Here, we cloned and functionally characterized a murine BM MSC subpopulation that was uniformly Nestin(+) Lepr (+) Sca-1(+) CD146(+) and could be stably propagated with high colony-forming unit fibroblast re-cloning efficiency...
August 19, 2016: Stem Cells
https://www.readbyqxmd.com/read/27535971/bazedoxifene-as-a-novel-gp130-inhibitor-for-pancreatic-cancer-therapy
#16
Xiaojuan Wu, Yang Cao, Hui Xiao, Chenglong Li, Jiayuh Lin
The IL6/GP130/STAT3 pathway is crucial for tumorigenesis in multiple cancer types, including pancreatic cancer, and presents as a viable target for cancer therapy. We reported Bazedoxifene, which is approved as a selective estrogen modulator by FDA, as a novel inhibitor of IL6/GP130 protein-protein interactions using multiple ligand simultaneous docking and drug repositioning approaches. STAT3 is one of the major downstream effectors of IL6/GP130. Here, we observed Bazedoxifene inhibited STAT3 phosphorylation and STAT3 DNA binding, induced apoptosis, and suppressed tumor growth in pancreatic cancer cells with persistent IL6/GP130/STAT3 signaling in vitro and in vivo In addition, IL6, but not INFγ, rescued Bazedoxifene-mediated reduction of cell viability...
November 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27524264/il-11-and-ccl-1-novel-protein-diagnostic-biomarkers-of-lung-adenocarcinoma-in-bronchoalveolar-lavage-fluid-balf
#17
Maria Delores Pastor, Ana Nogal, Sonia Molina-Pinelo, Álvaro Quintanal-Villalonga, Ricardo Meléndez, I Ferrer, Beatrice Romero-Romero, Maria José De Miguel, José Luis López-Campos, Jesús Corral, Rocío García-Carboner, Amancio Carnero, Luis Paz-Ares
INTRODUCTION: Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are smoking-related diseases, with the presence of COPD itself increasing the risk for development of LC, probably owing to underlying inflammation. LC is typically detected at late stages of the disease and carries a poor prognosis. There is an unmet need for methods to facilitate the early detection of LC in high-risk subjects such as smokers. METHODS: The expression of inflammatory proteins in bronchoalveolar lavage fluid (BALF) samples was studied by antibody arrays in a prospective cohort of 60 smokers of more than 30 pack-years divided into four groups (control, patients with LC, patients with COPD, and patients with LC plus COPD)...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27497989/cell-specific-paracrine-actions-of-il-6-family-cytokines-from-bone-marrow-and-muscle-that-control-bone-formation-and-resorption
#18
Natalie A Sims
Bone renews itself and changes shape throughout life to account for the changing needs of the body; this requires co-ordinated activities of bone resorbing cells (osteoclasts), bone forming cells (osteoblasts) and bone's internal cellular network (osteocytes). This review focuses on paracrine signaling by the IL-6 family of cytokines between bone cells, bone marrow, and skeletal muscle in normal physiology and in pathological states where their levels may be locally or systemically elevated. These functions include the support of osteoclast formation by osteoblast lineage cells in response to interleukin 6 (IL-6), interleukin 11 (IL-11), oncostatin M (OSM) and cardiotrophin 1 (CT-1)...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27493449/generation-of-soluble-interleukin-11-and-interleukin-6-receptors-a-crucial-function-for-proteases-during-inflammation
#19
REVIEW
Juliane Lokau, Maria Agthe, Christoph Garbers
The cytokines interleukin-11 (IL-11) and IL-6 are important proteins with well-defined pro- and anti-inflammatory functions. They activate intracellular signaling cascades through a homodimer of the ubiquitously expressed signal-transducing β-receptor glycoprotein 130 (gp130). Specificity is gained through the cell- and tissue-specific expression of the nonsignaling IL-11 and IL-6 α-receptors (IL-11R and IL-6R), which determine the responsiveness of the cell to these two cytokines. IL-6 is a rare example, where its soluble receptor (sIL-6R) has agonistic properties, so that the IL-6/sIL-6R complex is able to activate cells that are usually not responsive to IL-6 alone (trans-signaling)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27487122/interleukin-11-promotes-epithelial-mesenchymal-transition-in-anaplastic-thyroid-carcinoma-cells-through-pi3k-akt-gsk3%C3%AE-signaling-pathway-activation
#20
Zhaoming Zhong, Zedong Hu, Yue Jiang, Ruimei Sun, Xue Chen, Hongying Chu, Musheng Zeng, Chuanzheng Sun
Metastasis is the major cause of treatment failure in anaplastic thyroid carcinoma (ATC) patients. In the preliminary study, we demonstrated that interleukin (IL)-11 expression is positively correlated with distant metastasis in ATC. However, the mechanisms underlying remain largely unknown. Here, we found that cobalt chloride (a hypoxia mimetic) promoted IL-11 expression via HIF-1α activation. Furthermore, the resultant increase in IL-11 expression significantly induced epithelial-mesenchymal transition (EMT) in ATC cells, accompanied by Akt/GSK3β pathway activation and increased invasive and migratory abilities...
July 25, 2016: Oncotarget
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