Hiroaki Murano, Sumito Inoue, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Yoichiro Otaki, Yukihiro Minegishi, Takumi Kitaoka, Mitsuru Futakuchi, Akira Igarashi, Michiko Nishiwaki, Takako Nemoto, Masamichi Sato, Maki Kobayashi, Kento Sato, Toshinari Hanawa, Osamu Miyazaki, Masafumi Watanabe
Cigarette smoking is known to be the leading cause of chronic obstructive pulmonary disease (COPD). However, the detailed mechanisms have not been elucidated. Platelet-activating factor (PAF), a potent inflammatory mediator, is involved in the pathogenesis of various respiratory diseases, such as bronchial asthma or COPD. We focused on lysophospholipid acyltransferase 9 (LPLAT9), a biosynthetic enzyme of PAF, in the pathogenesis of COPD. LPLAT9 gene expression was observed in excised COPD lungs and single-cell RNA sequencing data of alveolar macrophage (AM)...
February 20, 2024: American Journal of Respiratory Cell and Molecular Biology