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Arterial thrombosis

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https://www.readbyqxmd.com/read/29050117/-pediatric-idiopathic-hypereosinophilic-syndrome-with-pulmonary-embolism-a-case-report-and-review-of-literature
#1
N Dong, X Y Dong
Objective: To explore clinical features of idiopathic hypereosinophilic syndrome combined with pulmonary embolism. Method: A retrospective analysis of a patient with idiopathic hypereosinophilic syndrome and pulmonary embolism diagnosed and treated in the Respiratory Department of Shanghai Children's Hospital in September 2016 was performed. A literature search was performed with"Eosinophils increased, thrombosis"as the Chinese keywords in Wanfang database and"idiopathic hypereosinophilic syndrome, deep vein thrombosis"as the English key words in PubMed database...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29049539/mid-and-long-term-outcome-comparisons-of-everolimus-eluting-bioresorbable-scaffolds-versus-everolimus-eluting-metallic-stents-a-systematic-review-and-meta-analysis
#2
Xin-Lin Zhang, Qing-Qing Zhu, Li-Na Kang, Xue-Ling Li, Biao Xu
Background: Percutaneous coronary interventions to implant bioresorbable vascular scaffolds (BVSs) were designed to reduce the late thrombotic events that occur with metallic stents. Purpose: To estimate the incidence of scaffold thrombosis after BVS implantation and compare everolimus-eluting BVSs with everolimus-eluting metallic stents (EESs) in terms of safety and efficacy at mid- and long-term follow-up in adults who had a percutaneous coronary intervention...
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29047360/comparison-of-circulating-dendritic-cell-and-monocyte-subsets-at-different-stages-of-atherosclerosis-insights-from-optical-coherence-tomography
#3
Jianhui Zhuang, Yang Han, Dachun Xu, Guofu Zhu, Shekhar Singh, Luoman Chen, Mengyun Zhu, Wei Chen, Yawei Xu, Xiankai Li
BACKGROUND: While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear. METHODS: Forty-eight patients with unstable angina pectoris (UAP) diagnosed by angiography were enrolled. Likewise, 31 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled and confirmed with the presence of thrombosis by angiography...
October 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29046468/-a-case-of-dural-arteriovenous-fistula-that-developed-21-months-after-cerebral-venous-sinus-thrombosis
#4
Motonori Ishii, Takashi Yamanouchi, Ryosuke Oshima, Masaki Sato, Tomoyuki Noda, Hideki Maki, Akira Kito
A 56-year-old man experienced a sudden onset of left hemiparesis. The computed tomography(CT)scan revealed a lobar hemorrhage in the right fronto-parietal lobe. After his admission, deep vein thrombosis was detected in his left lower limb, and angiograms taken on the 36th day of hospitalization revealed cerebral venous sinus thrombosis. Anticoagulant treatment was induced. After 21 months, he experienced a sudden onset of left hemiparesis again. The CT scan revealed a new lobar hemorrhage in the right frontal lobe, and angiograms revealed that two dural arteriovenous fistulas(dAVF)developed in the superior sagittal sinus(SSS)and the left transverse-sigmoid sinus...
October 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29045897/monocyte-macrophages-and-t-cells-in-atherosclerosis
#5
REVIEW
Ira Tabas, Andrew H Lichtman
Atherosclerosis is an arterial disease process characterized by the focal subendothelial accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells, and extracellular matrix. The lipoproteins acquire features of damage-associated molecular patterns and trigger first an innate immune response, dominated by monocyte-macrophages, and then an adaptive immune response. These inflammatory responses often become chronic and non-resolving and can lead to arterial damage and thrombosis-induced organ infarction...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045242/roles-of-the-microsurgeon-and-anesthesiologist-in-the-treatment-of-neonatal-upper-extremity-arterial-thrombosis-a-case-report
#6
Alexandra M Keane, Katherine B Santosa, Sonia M Shahrawat, Alison K Snyder-Warwick
We present a rare case of a newborn with spontaneous, noniatrogenic arterial thromboembolism in the right brachial artery and accompanying ischemic changes to the right upper extremity, who was successfully treated with microsurgical intervention and ultrasound-guided infraclavicular brachial plexus block with a continuous infusion of ropivacaine for 48 hours. This case report highlights the emerging role of both the microsurgeon and anesthesiologist in management of spontaneous neonatal arterial thromboembolism...
October 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29045041/orbital-and-rotational-atherectomy-during-percutaneous-coronary-intervention-for-coronary-artery-calcification
#7
Michael S Lee, Jonathan S Gordin, Gregg W Stone, Samin K Sharma, Shigeru Saito, Ehtisham Mahmud, Jeff Chambers, Philippe Généreux, Richard Shlofmitz
Severe coronary artery calcification (CAC) increases the complexity of percutaneous coronary intervention (PCI) by inhibiting optimal stent expansion, leading to an increased risk of death, myocardial infarction, repeat revascularization, and stent thrombosis. Coronary atherectomy modifies and debulks calcified plaque to facilitate PCI. Although there is no clear consensus, and further studies are needed, the decision to perform atherectomy should be based upon the presence of fluoroscopic CAC or with the use of intravascular imaging...
October 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29045015/the-small-molecule-mertk-inhibitor-unc2025-decreases-platelet-activation-and-prevents-thrombosis
#8
Brian R Branchford, Timothy J Stalker, Luke Law, Gilbert Acevedo, Susan Sather, Christine Brzezinski, Katina M Wilson, Katherine Minson, Alisa B Lee-Sherick, Pavel Davizon-Castillo, Christopher Ng, Weihe Zhang, Keith B Neeves, Steven R Lentz, Xiaodong Wang, Stephen V Frye, H Shelton Earp, Deborah DeRyckere, Lawrence F Brass, Douglas K Graham, Jorge A Di Paola
BACKGROUND: Gas6 signals through the TAM (TYRO-3, AXL, MERTK) receptor family mediating platelet activation and thrombus formation via activation of the aggregate-stabilizing αIIb β3 integrin. OBJECTIVE: Here we describe anti-thrombotic effects mediated by UNC2025, a small molecule MERTK tyrosine kinase inhibitor. METHODS: MERTK phosphorylation and downstream signaling were assessed by immunoblot. Light transmission aggregometry, flow cytometry, and microfluidic analysis were used to evaluate the impact of MERTK inhibition on platelet activation and stability of aggregate formation in vitro...
October 17, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29043581/the-unique-blood-pressures-and-pulsatility-of-lvad-patients-current-challenges-and-future-opportunities
#9
REVIEW
Francesco Castagna, Eric J Stöhr, Alberto Pinsino, John R Cockcroft, Joshua Willey, A Reshad Garan, Veli K Topkara, Paolo C Colombo, Melana Yuzefpolskaya, Barry J McDonnell
An increasing number of end-stage heart failure patients are now implanted with continuous-flow left ventricular assist devices (CF-LVADs). Although this therapeutic approach is associated with improved clinical outcomes, continuous flow physiology reduces arterial pulse pressure and pulsatility to an extent that is unique to this population. Recent data suggest that high blood pressure (BP) contributes to life-threatening complications such as pump thrombosis and stroke of CF-LVAD patients. However, limited understanding of the distinct hemodynamics of these pumps makes measurement and, consequently, medical management of BP quite challenging...
October 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29041891/-functional-state-of-vascular-endothelium-in-patients-with-pulmonary-arterial-hypertension-associated-with-congenital-heart-diseases
#10
Y E Emelyanchik, G N Vol'f, A O Vesemiller, B A Salmina
In this article, we present results of the study of blebbing activity of membranes of peripheral blood lymphocytes, concentrations of soluble platelet/endothelial cell adhesion molecule 1, and vascular endothelial growth factor (VEGF) in patients with pulmonary arterial hypertension associated with congenital heart diseases. The research has shown that hypoxia and hemodynamic factors are the initiators of blebbing of membrane of peripheral blood lymphocytes. The activity of blebbing increases in parallel with the severity of the disease...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041831/postoperative-complications-after-lower-extremity-arterial-bypass-increase-the-risk-of-new-deep-venous-thrombosis
#11
Faisal Aziz, Erik Lehman, John Blebea, Fedor Lurie
Background Deep venous thrombosis after any surgical operations is considered a preventable complication. Lower extremity bypass surgery is a commonly performed operation to improve blood flow to lower extremities in patients with severe peripheral arterial disease. Despite advances in endovascular surgery, lower extremity arterial bypass remains the gold standard treatment for severe, symptomatic peripheral arterial disease. The purpose of this study is to identify the clinical risk factors associated with development of deep venous thrombosis after lower extremity bypass surgery...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/29041001/hmgb1-expression-level-in-circulating-platelets-is-not-significantly-associated-with-outcomes-in-symptomatic-coronary-artery-disease
#12
Dominik Rath, Tobias Geisler, Meinrad Gawaz, Sebastian Vogel
BACKGROUND/AIMS: Platelets express high-mobility group box 1 (HMGB1), a damage-associated molecular pattern molecule (DAMP) that triggers thrombosis and inflammation when present in extracellular space. The role of platelet-derived HMGB1 in coronary artery disease (CAD) remains unexplored. METHODS: In a cohort study, we measured the expression of HMGB1 on the surface of circulating platelets in 183 patients with symptomatic CAD (stable CAD: n=80, acute coronary syndrome, ACS: n=103) at the time of percutaneous coronary intervention...
October 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29038140/teaching-neuroimages-artery-of-percheron-thrombosis-causing-selective-downgaze-palsy
#13
Matthew Sechler, Jasmeet Singh, Nada El Husseini
No abstract text is available yet for this article.
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/29037856/platelet-cd40-mediates-leukocyte-recruitment-and-neointima-formation-after-arterial-denudation-injury-in-atherosclerosis-prone-mice
#14
Rong Jin, Adam Y Xiao, Zifang Song, Shiyong Yu, Jarvis Li, Mei-Zhen Cui, Guohong Li
The role of platelets in the development of thrombosis and abrupt closure after angioplasty is well recognized. However, the direct impact of platelets on neointima formation after arterial injury remains undetermined. Here we show that neointima formation after carotid artery wire injury reduces markedly in CD40(-/-)apoE(-/-) mice but only slightly in CD40L(-/-)apoE(-/-) mice, compared with apolipoprotein E-deficient (apoE(-/-)) mice. Wild-type and CD40-deficient platelets were isolated from blood of apoE(-/-) and CD40(-/-)apoE(-/-) mice, respectively...
October 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29037842/puerarin-inhibits-expression-of-tissue-factor-induced-by-oxidative-low-density-lipoprotein-through-activating-the-pi3k-akt-enos-pathway-and-inhibiting-activation-of-erk1-2-and-nf-%C3%AE%C2%BAb
#15
Hue-Fei Deng, Xiao-Li Wang, Hui Sun, Xian-Zhong Xiao
AIMS: The present study aimed to investigate whether puerarin regulated tissue factor (TF) expression induced by oxidative low-density lipoprotein (ox-LDL), an independent risk factor for atherosclerosis, and its mechanisms. MAIN METHODS: TF expression at the mRNA level was determined by reverse transcription-quantitative polymerase chain reaction, and its expression at the protein level, as well as other target proteins, was assessed by western blotting. Nitric oxide (NO) production was measured by a nitrate reduction method...
October 13, 2017: Life Sciences
https://www.readbyqxmd.com/read/29034044/bronchial-artery-aneurysm-treated-using-aortic-stent-graft-alone-a-case-report
#16
Takashi Matsumoto, Takayuki Uchida, Tomoyuki Ono, Kazuto Hirayama, Fumio Fukumura, Hiromi Ando, Jiro Tanaka
A 72-year-old woman with a history of malignant lymphoma was referred to our hospital for the treatment of a bronchial artery aneurysm. Computed tomography (CT) scan showed a round, 30 mm-diameter fusiform aneurysm with two tortuous inflow arteries. We deployed thoracic stent grafting to cover the orifice of the two inflow arteries without transcatheter bronchial arterial embolization. Postoperative CT scan revealed complete thrombosis of the aneurysm. Although further follow-up is mandatory, this may be considered a viable treatment option in cases wherein the bronchial artery aneurysm is anatomically difficult to treat...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29034034/pathophysiology-of-venous-thromboembolism-with-respect-to-the-anatomical-features-of-the-deep-veins-of-lower-limbs-a-review
#17
REVIEW
Ayako Ro, Norimasa Kageyama, Toshiji Mukai
Here the pathophysiology of venous thromboembolism is reviewed with respect to the anatomical features of the deep veins of lower limbs. A thrombus is less likely to form in the thigh veins compared with that in the calf veins; however, clinical symptoms are more likely to appear in the thigh veins owing to vascular occlusion. When a patient is bedridden, thrombosis is more likely to occur in the intramuscular vein, which mainly depends on muscular pumping and the venous valve, rather than in the three crural branches, which mainly depends on the pulsation of the accompanying artery...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29033499/fabrication-and-characterization-of-electrospun-thermoplastic-polyurethane-fibroin-small-diameter-vascular-grafts-for-vascular-tissue-engineering
#18
E Yu, J Zhang, J A Thomson, L-S Turng
The demand for small-diameter blood vessel substitutes has been increasing due to a shortage of autograft vessels and problems with thrombosis and intimal hyperplasia with synthetic grafts. In this study, hybrid small-diameter vascular grafts made of thermoplastic polyurethane (TPU) and silk fibroin, which possessed a hybrid fibrous structure of an aligned inner layer and a random outer layer, were fabricated by the electrospinning technique using a customized striated collector that generated both aligned and random fibers simultaneously...
November 2016: Int Polym Process
https://www.readbyqxmd.com/read/29032800/haemodynamic-effects-of-incomplete-stent-apposition-in-curved-coronary-arteries
#19
Winson X Chen, Eric K W Poon, Vikas Thondapu, Nicholas Hutchins, Peter Barlis, Andrew Ooi
Incomplete stent apposition (ISA, also known as malapposition) is a complication that affects day-to-day coronary stenting procedures. ISA is more prominent in complex arterial geometries, such as curvature, asa result of the limited conformability of coronary stents. These malapposed struts disturb the otherwise near-wall laminar blood flow and form a micro-recirculation environment. The micro-recirculation environment is often associated with low wall shear stress (WSS) and upsets the delicate balance of vascular biology, providing possible nidus for thrombosis and restenosis...
October 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29032587/team-preparation-for-human-uterus-transplantation-autologous-transplantation-in-sheep-model
#20
Evgeny Solomonov, Naama Marcus Braun, Yariv Siman-Tov, Inbar Ben Shachar
We performed autologous uterus transplantation using the living-sheep donor model for team preparation before human uterine transplantation. Five sequential operations (in 3 ewes) were prospectively conducted. Surgical technique included uterus retrieval, graft preparation, and uterus transplantation. Anastomoses were performed at the level of the external iliac. At 3 weeks follow-up, the uterus and anastomoses were checked for strictures and thrombosis. Two successful auto-transplantations were made, and one failed because of undeveloped uterine arteries (< 1 mm in diameter)...
October 15, 2017: Clinical Transplantation
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