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https://www.readbyqxmd.com/read/29332233/pilot-study-of-serial-flt-and-fdg-pet-ct-imaging-to-monitor-response-to-neoadjuvant-chemoradiotherapy-of-esophageal-adenocarcinoma-correlation-with-histopathologic-response
#1
Victor H Gerbaudo, Joseph H Killoran, Chun K Kim, Jason L Hornick, Jonathan A Nowak, Peter C Enzinger, Harvey J Mamon
OBJECTIVE: The aim of this prospective pilot study was to investigate the potential of serial FLT-PET/CT compared to FDG-PET/CT to provide an early indication of esophageal cancer response to concurrent neoadjuvant chemoradiation therapy. METHODS: Five patients with biopsy-proven esophageal adenocarcinomas underwent neoadjuvant chemoradiation (Tx) prior to minimally invasive esophagectomy. The presence of residual tumor was classified histologically using the Mandard et al...
January 13, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29332161/the-computed-tomography-adrenal-wash-out-analysis-properly-classifies-cortisol-secreting-adrenocortical-adenomas
#2
Anne-Laure Humbert, Guillaume Lecoanet, Sophie Moog, Fehd Bouderraoui, Laurent Bresler, Jean-Michel Vignaud, Elodie Chevalier, Laurent Brunaud, Marc Klein, Thomas Cuny
PURPOSE: Adrenocortical lesions are characterized through imaging, hormonal and histopathological analysis. Our aim was to compare the radiological features of adrenocortical lesions with their cortisol-secreting status and histopathological Weiss score. METHODS: Seventy five patients operated between 2004 and 2016 in the University Hospital of Nancy for either adrenocortical carcinomas (ACC) or adrenocortical adenomas (ACA) were enrolled in this study. We collected cortisol parameters, Computed Tomography (CT) scans (unenhanced density, wash-out (WO) analysis) and 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) datas...
January 13, 2018: Endocrine
https://www.readbyqxmd.com/read/29331979/now-you-see-me-a-pragmatic-cohort-study-comparing-first-and-final-radiological-diagnoses-in-the-emergency-department
#3
Björn Mattsson, David Ertman, Aristomenis Konstantinos Exadaktylos, Luca Martinolli, Wolf E Hautz
OBJECTIVES: To (1) compare timely but preliminary and definitive but delayed radiological reports in a large urban level 1 trauma centre, (2) assess the clinical significance of their differences and (3) identify clinical predictors of such differences. DESIGN, SETTING AND PARTICIPANTS: We performed a retrospective record review for all 2914 patients who presented to our university affiliated emergency department (ED) during a 6-week period. In those that underwent radiological imaging, we compared the patients' discharge letter from the ED to the definitive radiological report...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331571/interdepartmental-imaging-protocol-for-clinically-based-three-dimensional-computed-tomography-can-provide-accurate-measurement-of-glenoid-version
#4
Connor L Zale, Gregory I Pace, Gregory S Lewis, John Chan, H Mike Kim
BACKGROUND: Conventional computed tomography (CT) is not accurate for glenoid version measurement. This study sought to examine the feasibility of an interdepartmental protocol implemented between orthopedic surgery and radiology departments for acquisition of anatomic axial CT images and to validate the glenoid version measured through such a protocol. MATERIALS AND METHODS: Data of 30 conventional CT scans of 10 normal and 20 osteoarthritic glenoids were transferred to clinical 3-dimensional imaging software by a radiology technician trained for the study...
January 10, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29330745/-treatment-of-rotational-malalignment-of-the-lower-leg
#5
REVIEW
P Keppler
BACKGROUND: Rotational malalignment after intramedullary nailing of tibial shaft fractures is not uncommon. In-toeing and out-toeing conditions in children are often the reason for orthopedic and traumatological medical consultation. OBJECTIVE: Evaluation of diagnostic modalities and therapeutic options for rotational malalignment in relationship to the patient's age. Surgical indications and efficacy of specific surgical techniques. MATERIAL AND METHODS: Systematic literature search in the German Institute for Medical Documentation and Information (DIMDI) and MEDLINE and evaluation of the currently published articles...
January 12, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29330668/impact-of-duplicate-ct-scan-rate-after-implementation-of-transfer-image-repository-system-at-a-level-1-trauma-center
#6
Charles W Sheppard, Amy L Groll, Cindy L Austin, Simon J Thompson
PURPOSE: The regionalization of trauma in the USA results in frequent transfers of patients from a primary hospital ED to a higher level trauma facility. While many hospitals have a Picture Archive Communication System (PACS) which captures digital radiological images, these are often not available to the receiving institution resulting in duplicate imaging. The state of Arkansas instituted a trauma image repository (TIR) in July 2013. We examined whether implementation of this repository would impact CT scan duplication in the trauma system...
January 12, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29330575/a-new-technique-for-minimal-invasive-complete-spinal-cord-injury-in-minipigs
#7
Elena E Foditsch, Gratian Miclaus, Irina Patras, Ioan Hutu, Karin Roider, Sophina Bauer, Günter Janetschek, Ludwig Aigner, Reinhold Zimmermann
BACKGROUND: The aim of this study was to develop a minimal invasive complete spinal cord injury (SCI) minipig model for future research applications. The minipig is considered a translationally relevant model for SCI research. However, a standardized minimal invasive complete SCI model for pigs has not yet been established. METHODS: Adult Göttingen minipigs were anesthetized and placed in extended prone position. After initial computed tomography (CT) scan, the skin was incised, a needle placed in the epidural fatty tissue...
January 12, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29330466/target-engagement-imaging-of-parp-inhibitors-in-small-cell-lung-cancer
#8
Brandon Carney, Susanne Kossatz, Benjamin H Lok, Valentina Schneeberger, Kishore K Gangangari, Naga Vara Kishore Pillarsetty, Wolfgang A Weber, Charles M Rudin, John T Poirier, Thomas Reiner
Insufficient chemotherapy response and rapid disease progression remain concerns for small-cell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment decisions, but this cannot assess in vivo target engagement of therapeutic agents. Biomarker assessments in biopsy material do not assess contemporaneous target expression, intratumoral drug exposure, or drug-target engagement. Here, we report the use of PARP1/2-targeted imaging to measure target engagement of PARP inhibitors in vivo. Using a panel of clinical PARP inhibitors, we show that PARP imaging can quantify target engagement of chemically diverse small molecule inhibitors in vitro and in vivo...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29329996/to-prep-or-not-to-prep-that-is-the-question-a-randomized-trial-on-the-use-of-antiflatulent-medication-as-part-of-bowel-preparation-for-patients-having-image-guided-external-beam-radiation-therapy-to-the-prostate
#9
Merrylee McGuffin, Naila Devji, Lyann Kehoe, Anne Carty, Steve Russell, Lisa Di Prospero, Carlo DeAngelis, Alex Kiss, Danny Vesprini, Andrew Loblaw, Laura D'Alimonte
INTRODUCTION: Radiation therapy is a standard treatment option for prostate cancer. With growing use of escalated doses and tighter margins, procedures to limit rectal size variation are needed to reduce prostate motion, increase treatment accuracy, and minimize rectal toxicity. This prospective study was done to determine whether the introduction of an antiflatulent medication would decrease rectal distention at computed tomography (CT) simulation and throughout a course of radiation therapy...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29329882/prognostic-significance-of-residual-lymph-node-status-after-definitive-chemoradiotherapy-in-patients-with-node-positive-cervical-cancer
#10
Shin-Hyung Park, Hyejin Cheon, Gun Oh Chong, Shin Young Jeong, Jeong Eun Lee, Min Kyu Kang, Mi Young Kim, Jeong Won Lee, Junhee Park, Jae-Chul Kim
OBJECTIVE: Lymph node involvement is an important prognostic factor in patients with cervical cancer. However, the prognostic significance of lymph node response to chemoradiotherapy remains unclear. We retrospectively analyzed the relationship between residual lymph node status after definitive chemoradiotherapy and survival. METHODS: We enrolled 117 patients with node-positive cervical cancer. All patients were treated with definitive chemoradiotherapy in our institution, from 2006 to 2016...
January 9, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29329443/bone-formation-in-ankylosing-spondylitis-during-anti-tumour-necrosis-factor-therapy-imaged-by-18f-fluoride-positron-emission-tomography
#11
Stefan T G Bruijnen, Nicki J F Verweij, Leonie M van Duivenvoorden, Nathalie Bravenboer, Dominique L P Baeten, Christiaan J van Denderen, Irene E van der Horst-Bruinsma, Alexandre E Voskuyl, Martijn Custers, Peter M van de Ven, Joost C J Bot, Bouke J H Boden, Adriaan A Lammertsma, Otto S H Hoekstra, Pieter G H M Raijmakers, Conny J van der Laken
Objectives: Excessive bone formation is an important hallmark of AS. Recently it has been demonstrated that axial bony lesions in AS patients can be visualized using 18F-fluoride PET-CT. The aim of this study was to assess whether 18F-fluoride uptake in clinically active AS patients is related to focal bone formation in spine biopsies and is sensitive to change during anti-TNF treatment. Methods: Twelve anti-TNF-naïve AS patients [female 7/12; age 39 years (SD 11); BASDAI 5...
January 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29329150/comparison-of-iodine-density-measurement-among-dual-energy-computed-tomography-scanners-from-3-vendors
#12
Hyungjin Kim, Jin Mo Goo, Chang Kyung Kang, Kum Ju Chae, Chang Min Park
OBJECTIVES: The aims of this study were to analyze the effect of dual-energy computed tomography (DECT) scanners and fluid characteristics on iodine quantification and to calculate the measurement variability range induced by those variables. METHODS: We performed an experimental phantom study with 4 mediastinal iodine phantoms. Each phantom contained 6 tubes of different iodine concentrations (0, 1.0, 2.5, 5.0, 10.0, and 20.0 mg/mL) diluted in a specific solvent, which was water, 10% amino acid solution, 20% lipid emulsion, or 18% calcium solution, respectively...
January 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29328049/pet-attenuation-correction-for-rigid-mr-tx-rx-coils-from-sup-176-sup-lu-background-activity
#13
Christoph W Lerche, Theodoros Kaltsas, Liliana Caldeira, Juergen J Scheins, Elena Rota Kops, Lutz Tellmann, Uwe Pietrzyk, Hans Herzog, Nadim Jon Shah
One challenge for PET-MR hybrid imaging is the correction for attenuation of the 511 keV annihilation radiation by the required RF transmit and/or RF receive coils. Although there are strategies for building PET transparent Tx/Rx coils, such optimised coils still cause signicant attenuation of the annihilation radiation leading to artefacts and biases in the reconstructed activity concentrations. We present a straightforward method to measure the attenuation of Tx/Rx coils in simultaneous MR-PET imaging based on the natural <sup>176</sup>Lu background contained in the scintillator of the PET detector without the requirement of an external CT scanner or PET scanner with transmission source...
January 12, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29328003/characterizing-the-type-and-location-of-intracranial-abnormalities-in-mild-traumatic-brain-injury
#14
Harri Isokuortti, Grant L Iverson, Noah D Silverberg, Anneli Kataja, Antti Brander, Juha Öhman, Teemu M Luoto
OBJECTIVE The incidence of intracranial abnormalities after mild traumatic brain injury (TBI) varies widely across studies. This study describes the characteristics of intracranial abnormalities (acute/preexisting) in a large representative sample of head-injured patients who underwent CT imaging in an emergency department. METHODS CT scans were systematically analyzed/coded in the TBI Common Data Elements framework. Logistic regression modeling was used to quantify risk factors for traumatic intracranial abnormalities in patients with mild TBIs...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29327553/-preliminary-development-of-drill-template-assisted-placement-of-reverse-intramedullary-lag-screw-for-superior-ramus-of-pubis-using-three-dimentional-print-technique
#15
Yi Zheng, Xin-Hua Yuan, Wei-Bin Wang, Qing-Jiang Pang
OBJECTIVE: To investigate the feasibility of a drill template for the placement of reverse intramedullary lag screws on the outside of the pubis based on digital design and 3D printing technology. METHODS: The preoperative CT images of a 23-year-old male patient with pelvic fracture were collected retrospectively. According to the Young and Burgess classification, the type of pelvic fracture was LC IIwith the 3D printing technology. The data was reconstructed by 3D imaging reconstruction software to produce 1:1 three dimensional model...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327247/comparing-different-modalities-for-the-diagnosis-of-incisional-hernia-a-systematic-review
#16
REVIEW
L F Kroese, D Sneiders, G J Kleinrensink, F Muysoms, J F Lange
PURPOSE: Incisional hernia (IH) is the most frequent complication after abdominal surgery. The diagnostic modality, observer, definition, and diagnostic protocol used for the diagnosis of IH potentially influence the reported prevalence. The objective of this systematic review is to evaluate the diagnostic accuracy of different modalities used to identify IH. METHODS: Embase, MEDLINE OvidSP, Web of Science, Google Scholar, and Cochrane databases were searched to identify studies diagnosing IH...
January 11, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29326136/using-correlative-properties-of-neighboring-pixels-to-improve-gray-white-differentiation-in-pediatric-head-ct-images
#17
T P Madaelil, A Sharma, C Hildebolt, M Parsons
BACKGROUND AND PURPOSE: A lower radiation dose can have a detrimental effect on the quality of head CT images. The aim of this study performed in a pediatric population was to test whether an image-processing algorithm (Correlative Image Enhancement) based on the correlation among intensities of neighboring pixels can improve gray-white differentiation in head CTs. MATERIALS AND METHODS: Sixty baseline head CT images with normal findings obtained from scans of 30 children were processed using Correlative Image Enhancement to produce corresponding enhanced images...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29325947/usefulness-of-oblique-coronal-ct-and-mri-imaging-in-the-endoscopic-endonasal-approach-to-treat-skull-base-lesions
#18
Shigetoshi Yano, Naoki Shinojima, Mika Kitajima, Hiroyuki Uetani, Takuichiro Hide, Akitake Mukasa
OBJECTIVE: This report examines the utility of the preoperative image to orientate the surgeon in the sphenoid sinus during an endoscopic endonasal transsphenoidal approach (ETSS). METHODS: ETSS was performed in 100 cases of sellar lesion and used to classify the sphenoid sinus septum shape. Preoperative CT and MRI scans were taken for two types of coronal imaging: conventional and oblique. Expected sphenoid sinus septum shape was compared with those from ETSS to estimate concordance...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325886/comparison-analysis-of-orbital-shape-and-volume-in-unilateral-fractured-orbits
#19
Johanna Nilsson, Johan Nysjö, Anders-Petter Carlsson, Andreas Thor
Facial fractures often result in changes of the orbital volume. These changes can be measured in three-dimensional (3D) computed tomography (CT) scans for preoperative planning and postoperative evaluation. The aim of this study was to analyze the orbital volume and shape before and after surgical treatment of unilateral orbital fractures using semi-automatic image segmentation and registration techniques. The orbital volume in 21 patients was assessed by a semi-automatic model-based segmentation method. The fractured orbit was compared relative to the contralateral orbit...
December 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29325834/a-computed-tomography-scan-based-template-to-place-the-femoral-component-in-accurate-rotation-with-respect-to-the-surgical-epicondylar-axis-in-total-knee-arthroplasty
#20
Yasushi Oshima, Norishige Iizawa, Tatsunori Kataoka, Tokifumi Majima, Shinro Takai
BACKGROUND: Femoral rotational alignment is considered an essential factor for total knee arthroplasty because malrotation of femoral components results in poor outcomes. To obtain proper alignment, we developed a superimposable computed tomography (CT) scan-based template to intraoperatively determine the accurate surgical epicondylar axis (SEA), and evaluated the effectiveness of this CT template. METHODS: In the experimental group (n=55), three serial slices of CT images, including medial and lateral epicondyles, were merged into a single image, and SEA was overlaid...
January 9, 2018: Knee
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