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Keywords Chronic renal disease and preg...

Chronic renal disease and pregnancy

https://read.qxmd.com/read/38520087/pregnancy-outcomes-for-women-with-pre-existing-renal-disease-and-the-role-of-a-dedicated-joint-maternal-medicine-and-renal-clinic-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Bethany Wildridge, David Makanjuola, Antoinette Johnson, Ramesh Ganapathy, Lucy Mountford, Christina Bell, Jonathan Odogwu, Hassan Shehata
OBJECTIVE: To reaffirm the value of a joint obstetric and renal clinic on obstetric outcomes in patients with high-risk pregnancies due to chronic kidney disease (CKD). METHODS: This was a retrospective cohort study of patients who attended the clinic between 2005 and December 2021. The hospital is a regional tertiary unit for renal medicine and a maternal medicine hub. The data included all women with pre-existing renal conditions who were cared for in a dedicated renal and obstetric clinic...
March 22, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38511086/how-the-kidney-regulates-magnesium-a-modelling-study
#2
JOURNAL ARTICLE
Pritha Dutta, Shervin Hakimi, Anita T Layton
The kidneys are crucial for maintaining Mg2+ homeostasis. Along the proximal tubule and thick ascending limb, Mg2+ is reabsorbed paracellularly, while along the distal convoluted tubule (DCT), Mg2+ is reabsorbed transcellularly via transient receptor potential melastatin 6 (TRPM6). TRPM6 and other renal transporter expressions are regulated by sex hormones. To investigate renal Mg2 handling, we have developed sex-specific computational models of electrolyte transport along rat superficial nephron. Model simulations indicated that along the proximal tubule and thick ascending limb, Mg2+ and Na+ transport occur parallelly, but they are dissociated along the DCT...
March 2024: Royal Society Open Science
https://read.qxmd.com/read/38487645/vaginoscopic-resection-of-hemivagina-in-a-20-year-old-virgin-female-with-prior-misdiagnosis-of-ohvira-syndrome-as-a-bicornuate-uterus-a-case-report
#3
Ameneh Haghgoo, Ali Faegh, Saeed Nasiri, Farnaz Akhbari
KEY CLINICAL MESSAGE: OHVIRA syndrome can be misdiagnosed due to its rarity, resulting in the need for more invasive interventions than vaginoscopy. Also, delayed diagnosis of OHVIRA syndrome can affect patient's quality of life by leading to chronic gynecological diseases such as endometriosis and pelvic inflammatory disease. ABSTRACT: Obstructive hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome is one of the infrequent congenital Mullerian duct anomalies characterized by obstructed hemivagina and ipsilateral renal agenesis...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38473987/placental-and-renal-pathways-underlying-pre-eclampsia
#4
REVIEW
Paraskevi Eva Andronikidi, Eirini Orovou, Eleftheria Mavrigiannaki, Virginia Athanasiadou, Maria Tzitiridou-Chatzopoulou, George Iatrakis, Eirini Grapsa
Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction. Chronic kidney disease is an established risk factor for the development of pre-eclampsia, as angiogenic homeostasis is altered and the maternal circulation is already hypertensive. Facing pre-eclampsia in the context of chronic kidney disease is a challenging emergency for both the mother and the fetus. The clinical features and the management of this multi-organ disorder are clearly defined in the modern literature but the underlying pathophysiologic mechanisms remain not fully elucidated...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38407871/prevalence-and-risk-factors-for-cirrhotic-cardiomyopathy-a-prospective-cross-sectional-study
#5
JOURNAL ARTICLE
Huawei Xu, Yu Zhang, Yanjing Gao
BACKGROUND: This study aimed to assess cardiac structure and function in patients with cirrhosis, to investigate the prevalence of cirrhotic cardiomyopathy (CCM) in patients with cirrhosis of different etiologies and to analyze the risk factors for the development of CCM. METHODS: This study selected cirrhotic patients aged 18-75 years who were hospitalized in Qilu Hospital of Shandong University. Patients with known heart disease, chronic lung disease, severe renal insufficiency, malignancy, thyroid disease, hypertension, diabetes or pregnancy were excluded...
April 1, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38370350/case-report-a-novel-compound-heterozygous-variant-in-the-tnxb-gene-causes-single-kidney-agenesis-and-vesicoureteral-reflux
#6
Lei Liang, Haotian Wu, Haixia Meng, Lin Fu, Jianrong Zhao
Primary vesicoureteral reflux (VUR) is the prevailing congenital anomaly of the kidneys and urinary tract, posing a significant risk for pyelonephritis scarring and chronic renal insufficiency in pediatric patients. Nevertheless, the precise genetic etiology of VUR remains enigmatic. In this current investigation, we conducted whole-exome sequencing on a child exhibiting single kidney, devoid of any familial VUR background, along with both biological parents. Two missense variants (NM_019105.8: exon11: c.4111G>A and NM_019105...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38355203/acute-renal-failure-as-a-key-to-significant-neonatal-weight-loss
#7
JOURNAL ARTICLE
Joana Moscoso, Margarida Serôdio, Ana Rita Prior
We present a case of a male neonate who experienced a 13.5% weight loss at 96 hours of life, despite receiving adequate calorie intake and exhibiting no feeding difficulties. The pregnancy was uneventful, and maternal serological investigation was normal. A routine ultrasound at 34 weeks of gestational age revealed late oligohydramnios. The neonate was delivered at 35 weeks of gestational age by forceps, weighing 2600 g. Physical examination disclosed bilateral cryptorchidism. Laboratory studies unveiled acute kidney injury (AKI) with hyperkalaemia...
February 14, 2024: BMJ Case Reports
https://read.qxmd.com/read/38343989/the-toxicity-of-mercury-and-its-chemical-compounds-molecular-mechanisms-and-environmental-and-human-health-implications-a-comprehensive-review
#8
REVIEW
Yuan-Seng Wu, Ahmed I Osman, Mohamed Hosny, Ahmed M Elgarahy, Abdelazeem S Eltaweil, David W Rooney, Zhonghao Chen, Nur Syafiqah Rahim, Mahendran Sekar, Subash C B Gopinath, Nur Najihah Izzati Mat Rani, Kalaivani Batumalaie, Pow-Seng Yap
Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at discussing the state-of-the-art progress on the recent developments on the toxicity of mercury and its chemical compounds. More than 210 recent works of literature are covered in this review. It first delineates the types (covering elemental mercury, inorganic mercury compounds, organic mercury compounds), structures, and sources of mercury. It then discusses the pharmacokinetic profile of mercury, molecular mechanisms of mercury toxicity, and clinical manifestation of acute and chronic mercury toxicity to public health...
February 6, 2024: ACS Omega
https://read.qxmd.com/read/38337471/albuminuria-forgotten-no-more-underlining-the-emerging-role-in-cardiorenal-crosstalk
#9
REVIEW
Gregorio Romero-González, Néstor Rodríguez-Chitiva, Carles Cañameras, Javier Paúl-Martínez, Marina Urrutia-Jou, Maribel Troya, Jordi Soler-Majoral, Fredzzia Graterol Torres, Maya Sánchez-Bayá, Jordi Calabia, Jordi Bover
Kidneys have an amazing ability to adapt to adverse situations, both acute and chronic. In the presence of injury, the kidney is able to activate mechanisms such as autoregulation or glomerular hyperfiltration to maintain the glomerular filtration rate (GFR). While these adaptive mechanisms can occur in physiological situations such as pregnancy or high protein intake, they can also occur as an early manifestation of diseases such as diabetes mellitus or as an adaptive response to nephron loss. Although over-activation of these mechanisms can lead to intraglomerular hypertension and albuminuria, other associated mechanisms related to the activation of inflammasome pathways, including endothelial and tubular damage, and the hemodynamic effects of increased activity of the renin-angiotensin-aldosterone system, among others, are recognized pathways for the development of albuminuria...
January 29, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38336098/management-of-dyslipidemia-in-special-groups
#10
JOURNAL ARTICLE
Jayagopal P B, Prafulla G Kerkar
Dyslipidemia management in situations like pregnancy, in diseases like rheumatoid arthritis, human immunodeficiency virus (HIV) disease, chronic liver disease, and in the elderly are challenging scenarios. Pregnancy is a contraindication for many drugs. The interaction of various drugs used in HIV infection and rheumatoid arthritis makes it even more difficult to treat with conventional and approved drugs for dyslipidemia. Elderly and chronic renal failure patients often do not tolerate the drugs very well and the data of dyslipidemia management is very different...
February 7, 2024: Indian Heart Journal
https://read.qxmd.com/read/38335157/fetal-loss-and-long-term-maternal-morbidity-and-mortality-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Florentia Vlachou, Despoina Iakovou, Jahnavi Daru, Rehan Khan, Litha Pepas, Siobhan Quenby, Stamatina Iliodromiti
BACKGROUND: Evidence suggests common pathways between pregnancy losses and subsequent long-term maternal morbidity, rendering pregnancy complications an early chronic disease marker. There is a plethora of studies exploring associations between miscarriage and stillbirth with long-term adverse maternal health; however, these data are inconclusive. METHODS AND FINDINGS: We systematically searched MEDLINE, EMBASE, AMED, BNI, CINAHL, and the Cochrane Library with relevant keywords and MeSH terms from inception to June 2023 (no language restrictions)...
February 2024: PLoS Medicine
https://read.qxmd.com/read/38292818/associated-factors-and-outcomes-of-acute-kidney-injury-in-covid-19-patients-in-kenya
#12
JOURNAL ARTICLE
Susan Cheruiyot, Jacob Shabani, Jasmit Shah, Catherine Gathu, Ahmed Sokwala
BACKGROUND: Corona Virus Disease 2019 (COVID-19), an infection caused by the SARS-CoV-2 virus, has been the largest global pandemic since the turn of the 21st century. With emerging research on this novel virus, studies from the African continent have been few. Corona Virus Disease 2019 has been shown to affect various organs including the lungs, gut, nervous system, and the kidneys. Acute kidney injury (AKI) is an independent risk factor for mortality and increases the health care burden for patients with persistent kidney dysfunction and maintenance dialysis...
2024: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/38285469/pregnancy-in-patients-receiving-home-dialysis
#13
JOURNAL ARTICLE
Ghada Ankawi, Nishanta Tangirala, Shilpanjali Jesudason, Michelle A Hladunewich
Pregnancy is an important goal for many women with chronic kidney disease (CKD) or kidney failure, but important barriers exist, particularly as CKD stage progresses. Women with advanced CKD often have a limited fertility window and may miss their opportunity for a pregnancy if advised to defer until after kidney transplantation. Pregnancy rates in women with advanced kidney failure or receiving dialysis remain low, and despite the improved outcomes in recent years, these pregnancies remain high risk for both mother and baby with high rates of preterm birth due to both maternal and fetal complications...
January 29, 2024: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/38285317/the-unanswered-question-when-to-undertake-a-maternity-journey
#14
JOURNAL ARTICLE
Dalia Younis, Rasha Samir Shemies
No abstract text is available yet for this article.
January 29, 2024: Journal of Nephrology
https://read.qxmd.com/read/38236469/pregnancy-associated-changes-in-urinary-uromodulin-excretion-in-chronic-hypertension
#15
JOURNAL ARTICLE
Sheon Mary, Fran Conti-Ramsden, Philipp Boder, Humaira Parveen, Dellaneira Setjiadi, Jessica Fleminger, Anna Brockbank, Delyth Graham, Kate Bramham, Lucy Charlotte Chappell, Christian Delles
BACKGROUND: Pregnancy involves major adaptations in renal haemodynamics, tubular, and endocrine functions. Hypertensive disorders of pregnancy are a leading cause of maternal mortality and morbidity. Uromodulin is a nephron-derived protein that is associated with hypertension and kidney diseases. Here we study the role of urinary uromodulin excretion in hypertensive pregnancy. METHODS: Urinary uromodulin was measured by ELISA in 146 pregnant women with treated chronic hypertension (n = 118) and controls (n = 28)...
January 18, 2024: Journal of Nephrology
https://read.qxmd.com/read/38222145/the-risk-of-persistent-hypertension-and-chronic-kidney-disease-in-early-and-late-onset-preeclampsia-a-report-from-developing-country
#16
JOURNAL ARTICLE
Ernawati Ernawati, Aditiawarman Aditiawarman, Agus Sulistyono, Kamalia Hasanah, Salsabilah N Ridfah, M Ilham A Akbar, Erry Gumilar Dachlan
BACKGROUND AND OBJECTIVE: Preeclampsia (PE) has been disproportionately prevalent in developing countries and constitutes a leading cause of maternal mortality, and also has long-term impacts, including renal consequences. This study aimed to explore the risk of persistent hypertension and kidney failure in early-onset PE (EOP) and late-onset PE (LOP) in the five years after delivery. METHODS: This retrospective cohort study included women with a prior history of severe PE or normotensive pregnancy admitted to tertiary hospitals in Indonesia...
December 2023: Curēus
https://read.qxmd.com/read/38149697/proteinuria-in-predicting-adverse-outcomes-in-women-with-severe-features-of-pre-eclampsia-from-a-developing-country-a%C3%A2-prospective-cohort-study
#17
JOURNAL ARTICLE
Akshaya Murali, Sasirekha Rengaraj, P S Priyamvada, Sindhu Sivanandan, Karthik R Udayakumar
OBJECTIVE: To study the adverse maternal and perinatal outcomes in women with severe pre-eclampsia (SPE) among different ranges of proteinuria. METHODS: This prospective cohort study was conducted in Jawaharlal Institute of Postgraduate Medical Education and Research, India. After obtaining informed written consent, the 202 singleton women fulfilling the criteria of severe features of pre-eclampsia were stratified based on the value of urine protein-creatinine ratio (UPCR) as mild, moderate, severe, and massive proteinuria during pregnancy...
December 27, 2023: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38117241/ophthalmic-artery-doppler-in-women-with-hypertensive-disorders-of-pregnancy-relationship-to-blood-pressure-control-and-renal-dysfunction-at-6-9%C3%A2-weeks-postnatally
#18
JOURNAL ARTICLE
K Gy Lau, M Bednorz, N Parisi, K H Nicolaides, N A Kametas
OBJECTIVE: To examine the postnatal course of the ophthalmic artery (OA) Doppler in women with hypertensive disorders of pregnancy (HDP) and evaluate the correlation between OA Dopplers and poor postnatal blood pressure control and renal dysfunction at 2-3 and 6-9 weeks postnatally. METHODS: Prospective cohort study of women with singleton pregnancies with HDP in a tertiary Pregnancy Hypertension clinic. Three visits were included: 1) the last antenatal hypertension clinic visit within 2 weeks prior to delivery, 2) 2-3 weeks postnatally, 3) 6-9 weeks postnatally...
December 20, 2023: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38115781/can-restless-legs-be-a-sign-of-something-else-a-case-report-of-spondyloarthritis-presenting-with-restless-legs-syndrome-and-a-review-of-the-literature
#19
REVIEW
E Yılmaz
Restless legs syndrome (RLS) is a chronic movement disorder characterized by an urge or need to move the limbs, usually associated with uncomfortable sensations in the legs and sleep disorders. In general, two clinical forms of RLS are described: primary and secondary. Although primary RLS has a familial component, the underlying mechanism is still not fully understood but seems to be related to abnormalities in the dopaminergic and glutamatergic pathways of the central nervous system. The secondary forms of the syndrome are associated with iron deficiency, renal failure, pregnancy, diabetes mellitus, peripheral neuropathy, and several rheumatologic disorders such as rheumatoid arthritis and Sjögren's syndrome...
December 19, 2023: Reumatismo
https://read.qxmd.com/read/38108616/antibiotic-use-during-pregnancy-in-sweden-a-nationwide-utilization-study-covering-2007-2019
#20
JOURNAL ARTICLE
Aya Olivia Nakitanda, Ingvild Odsbu, Björn Pasternak, Pär Karlsson, Laura Pazzagli
INTRODUCTION: Antibiotics are often prescribed during pregnancy. Assessing the current state of prenatal antibiotic use is therefore imperative for optimizing prescribing and identifying emerging research priorities. The study aimed to describe recent trends and patterns in antibiotic use during pregnancy among women who gave birth in Sweden, including user characteristics. MATERIAL AND METHODS: Population-based descriptive study using linked nationwide registers...
December 18, 2023: Acta Obstetricia et Gynecologica Scandinavica
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