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Cytokines dialysis

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https://www.readbyqxmd.com/read/27859980/isolation-of-bacterial-dna-followed-by-sequencing-and-differing-cytokine-response-in-peritoneal-dialysis-effluent-help-in-identifying-bacteria-in-culture-negative-peritonitis
#1
Narayan Prasad, Kamini Singh, Amit Gupta, Kashi Nath Prasad
BACKGROUND: The treatment of peritoneal dialysis related culture negative peritonitis is empirical which increases the cost of therapy and moreover antibiotic resistance. We aimed the study to isolate bacterial DNA from PD effluent and indentify bacteria causing peritonitis in culture negative situations. We have also studied the cytokine response with different bacteria causing peritonitis. METHODS: We have isolated bacterial DNA from PD effluent of culture negative and culture positive peritonitis patients...
November 16, 2016: Nephrology
https://www.readbyqxmd.com/read/27843814/dimeric-and-trimeric-fusion-proteins-generated-with-fimbrial-adhesins-of-uropathogenic-escherichia-coli
#2
Víctor M Luna-Pineda, Juan Pablo Reyes-Grajeda, Ariadnna Cruz-Córdova, Zeus Saldaña-Ahuactzi, Sara A Ochoa, Carmen Maldonado-Bernal, Vicenta Cázares-Domínguez, Leticia Moreno-Fierros, José Arellano-Galindo, Rigoberto Hernández-Castro, Juan Xicohtencatl-Cortes
Urinary tract infections (UTIs) are associated with high rates of morbidity and mortality worldwide, and uropathogenic Escherichia coli (UPEC) is the main etiologic agent. Fimbriae assembled on the bacterial surface are essential for adhesion to the urinary tract epithelium. In this study, the FimH, CsgA, and PapG adhesins were fused to generate biomolecules for use as potential target vaccines against UTIs. The fusion protein design was generated using bioinformatics tools, and template fusion gene sequences were synthesized by GenScript in the following order fimH-csgA-papG-fimH-csgA (fcpfc) linked to the nucleotide sequence encoding the [EAAAK]5 peptide...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27837150/il-6-trans-signaling-links-inflammation-with-angiogenesis-in-the-peritoneal-membrane
#3
Rusan Catar, Janusz Witowski, Nan Zhu, Christian Lücht, Alicia Derrac Soria, Javier Uceda Fernandez, Lei Chen, Simon A Jones, Ceri A Fielding, Andras Rudolf, Nicholas Topley, Duska Dragun, Achim Jörres
Vascular endothelial growth factor (VEGF) is implicated in the peritoneal membrane remodeling that limits ultrafiltration in patients on peritoneal dialysis (PD). Although the exact mechanism of VEGF induction in PD is unclear, VEGF concentrations in drained dialysate correlate with IL-6 levels, suggesting a link between these cytokines. Human peritoneal mesothelial cells (HPMCs), the main source of IL-6 and VEGF in the peritoneum, do not bear the cognate IL-6 receptor and are thus unable to respond to classic IL-6 receptor signaling...
November 11, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27814627/oxidative-dna-and-mitochondrial-dna-change-in-patients-with-sle
#4
Hui-Ting Lee, Tsai-Hung Wu, Chen-Sung Lin, Chyou-Shen Lee, Siao-Cian Pan, Deh-Ming Chang, Yau-Huei Wei, Chang-Youh Tsai
We evaluated plasma IL-10, IFN-alpha, IL-23, IFN-gamma, IP-10, MCP-1, 8-OHdG, leukocyte mtDNA, serum anti-dsDNA antibodies and disease activity index (SLEDAI) in SLE patients. 93 patients (35 nephritis, 4 under dialysis, 5 under rituximab) and 50 healthy controls were recruited. Compared with healthy controls, SLE patients had higher IL-10, IFN-alpha, IL-23, IFN-gamma, IP-10 and MCP-1 (p<0.05). High IFN-alpha (p=0.031) and IP-10 (p=0.026) correlated with high SLEDAI; high IFN-alpha (p<0.001), IL-23 (p=0...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27811451/expressions-of-macrophage-migration-inhibitory-factor-in-patients-with-chronic-kidney-disease
#5
Y Liu, X Zhang, G Liu, J Huang, Y Pan, Z Hu
CONTEXT: Uremic cardiomyopathy is a risk factor of end-stage renal disease (ESRD) and is responsible for high mortality rates and increased left ventricular mass index (LVMI). Macrophage migration inhibitory factor (MIF) promotes inflammation and is an important factor in uremic cardiomyopathy. AIMS: The aim of this study is to investigate the effects of serum macrophage MIF on myocardial hypertrophy in ESRD patients and to examine the relation of this factor to clinical characteristics...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27783636/online-haemodiafiltration-improves-inflammatory-state-in-dialysis-patients-a-longitudinal-study
#6
Ines Rama, Ines Llaudó, Pere Fontova, Gema Cerezo, Carlos Soto, Casimiro Javierre, Miguel Hueso, Nuria Montero, Alberto Martínez-Castelao, Juan Torras, Josep M Grinyó, Josep M Cruzado, Nuria Lloberas
BACKGROUND: Patients undergoing conventional hemodialysis (C-HD) present a greater immuno-inflammatory state probably related to uremia, sympathetic nervous system (SNS) activation and /or membrane bioincompatibility, which could improve with a technique-switching to online hemodiafiltration (OL-HD). The antigen-independent pathway activation of this modified immunologic state turns dendritic cells (DC) into an accurate cell model to study these patients. The aim of this study is to further evaluate the immune-inflammatory state of patients in C-HD assessed by DC maturation...
2016: PloS One
https://www.readbyqxmd.com/read/27768727/addition-of-alanyl-glutamine-to-dialysis-fluid-restores-peritoneal-cellular-stress-responses-a-first-in-man-trial
#7
Klaus Kratochwill, Michael Boehm, Rebecca Herzog, Katharina Gruber, Anton Michael Lichtenauer, Lilian Kuster, Dagmar Csaicsich, Andreas Gleiss, Seth L Alper, Christoph Aufricht, Andreas Vychytil
BACKGROUND: Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate peritoneal injury associated with PD fluid exposure, potentially due to peritoneal glutamine depletion. In this randomized cross-over phase I/II trial we investigated cytoprotective effects of alanyl-glutamine (AlaGln) addition to glucose-based PDF. METHODS: In a prospective randomized cross-over design, 20 stable PD outpatients underwent paired peritoneal equilibration tests 4 weeks apart, using conventional acidic, single chamber 3...
2016: PloS One
https://www.readbyqxmd.com/read/27663212/comparison-of-serum-levels-of-il-18-in-peripheral-blood-of-patients-with-type-ii-diabetes-with-nephropathy-clinical-protests-and-patients-with-type-ii-diabetes-without-nephropathy-clinical-protests
#8
M Mir, A Rostami, M Hormozi
BACKGROUND AND AIM: Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes...
August 31, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27515210/hypothesis-phytate-is-an-important-unrecognised-nutrient-and-potential-intravenous-drug-for-preventing-vascular-calcification
#9
Pieter Joubert, Markus Ketteler, Carolina Salcedo, Joan Perello
Cardiovascular calcification (CVC) associated with conditions such as ageing, diabetes or renal impairment, results from the deposition of hydroxyapatite in the endothelium or media of blood vessels. Key medical management options are directed towards controlling plasma calcium and phosphate concentrations (e.g. parathormone inhibition, phosphate binders, dialysis), enhancing the effect of calcification inhibitors (e.g. fetuin-A, pyrophosphate, vitamin K, osteopontin, matrix Gla protein) and decreasing the effect of promoters of calcification (e...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27496454/prognostic-value-of-proinflammatory-markers-in-patients-after-kidney-transplantation-in-relation-to-the-presence-of-diabetes
#10
D Cieniawski, P Miarka, E Ignacak, A Bętkowska-Prokop, M Waluś-Miarka, B Idzior-Waluś, M Kuźniewski, W Sułowicz
BACKGROUND: Patients who are receiving immunosuppressive treatment after kidney transplantation are at greater risk of developing new-onset diabetes after transplantation (NODAT). New biochemical markers that may contribute to a better assessment of the prognosis of renal failure for patients diagnosed with diabetes mellitus (DM) are needed. The aim of this study was to assess selected proinflammatory markers in patients after kidney transplantation depending on the prevalence of DM and to evaluate the predictive value of these cytokines...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27413076/premature-t-cell-senescence-in-pediatric-ckd
#11
Roshan P George, Aneesh K Mehta, Sebastian D Perez, Pamela Winterberg, Jennifer Cheeseman, Brandi Johnson, Jean Kwun, Stephanie Monday, Linda Stempora, Barry Warshaw, Allan D Kirk
An individual's immune function, susceptibility to infection, and response to immunosuppressive therapy are influenced in part by his/her T cell maturation state. Although childhood is the most dynamic period of immune maturation, scant information regarding the variability of T cell maturation in children with renal disease is available. In this study, we compared the T cell phenotype in children with renal failure (n=80) with that in healthy children (n=20) using multiparameter flow cytometry to detect markers of T cell maturation, exhaustion, and senescence known to influence immune function...
July 13, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27378515/il-10-differentially-controls-the-infiltration-of-inflammatory-macrophages-and-antigen-presenting-cells-during-inflammation
#12
Chia-Te Liao, Marcela Rosas, Luke C Davies, Peter J Giles, Victoria J Tyrrell, Valerie B O'Donnell, Nicholas Topley, Ian R Humphreys, Donald J Fraser, Simon A Jones, Philip R Taylor
The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signals that differentially influence their effector characteristics are poorly characterized. In this study, we defined the phenotype of discrete subsets of effective antigen-presenting cells (APCs) in the peritoneal cavity during peritonitis...
September 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27345902/direct-peritoneal-resuscitation-alters-hepatic-mirna-expression-after-hemorrhagic-shock
#13
Jessica L Weaver, Paul J Matheson, Ryan T Hurt, Cynthia D Downard, Craig J McClain, R Neal Garrison, Jason W Smith
BACKGROUND: MicroRNAs (miRNAs) are small segments of noncoding RNA that regulate gene expression and protein function, and therefore are key regulators of cellular processes including those of the inflammatory cascade after hemorrhagic shock (HS). We have previously shown that direct peritoneal resuscitation (DPR), as an adjunct to traditional IV fluid resuscitation, improves visceral blood flow and reduces pro-inflammatory cytokines released during HS. The effects of DPR on hepatic miRNA (miR) expression patterns after resuscitated HS are not known...
July 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27345001/association-between-asymmetric-dimethylarginine-and-pentosidine-in-dialysis-effluent-of-peritoneal-dialysis-patients-a-possible-intraperitoneal-crosstalk-between-asymmetric-dimethylarginine-and-advanced-glycation-end-products-in-peritoneal-dialysis-patients
#14
Mari Ishida, Takatoshi Kakuta, Takayo Miyakogawa, Ryoko Tatsumi, Chiemi Matsumoto, Masafumi Fukagawa
OBJECTIVE: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase. Elevated serum ADMA concentration is associated with impaired vascular endothelial function. We examined the relationships of ADMA with pentosidine, a representative advanced glycation end product, cytokines and the markers of peritoneal inflammation, damage and repair in dialysate effluent of peritoneal dialysis patients. METHODS: Study design was cross-sectional...
2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27275161/angiogenic-factors-and-risks-of-technique-failure-and-cardiovascular-events-in-patients-receiving-peritoneal-dialysis
#15
Masaru Matsui, Ken-Ichi Samejima, Yukiji Takeda, Katsuhiko Morimoto, Miho Tagawa, Kenji Onoue, Satoshi Okayama, Hiroyuki Kawata, Rika Kawakami, Yasuhiro Akai, Hiroyuki Okura, Yoshihiko Saito
BACKGROUND: Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family that acts as a pleiotropic cytokine capable of stimulating angiogenesis and accelerating atherogenesis. Soluble fms-like tyrosine kinase-1 (sFlt-1) antagonizes PlGF action. Higher levels of PlGF and sFlt-1 have been associated with cardiovascular events in patients with chronic kidney disease, yet little is known about their relationship with adverse outcomes in patients on peritoneal dialysis (PD)...
May 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27267129/cytokines-adipocytokines-and-inflammatory-markers-in-patients-on-continuous-ambulatory-peritoneal-dialysis-and-hemodialysis
#16
Mufide Oncel, Seval Akbulut, Turkan Toka Ozer, Aysel Kiyici, Mustafa Keles, Beyhan Baltaci, Suleyman Turk
BACKGROUND: Cytokines are essential mediators of immune response. Chronic renal failure patients suffer from chronic inflammation that results from factors such as impaired renal function, accumulation of uremic toxins and bio incompatibility of dialyzer membranes. These patients are also at increased risk of cardiovascular diseases. We have evaluated cytokines, adipocytokines and inflammatory markers in patients with chronic renal failure undergoing hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD)...
August 2016: Renal Failure
https://www.readbyqxmd.com/read/27192398/cationic-polyphosphazene-vesicles-for-cancer-immunotherapy-by-efficient-in-vivo-cytokine-il-12-plasmid-delivery
#17
Menghua Gao, Xiumei Zhu, Liping Wu, Liyan Qiu
To circumvent the severe toxicity of the systemic delivery of IL-12 protein and the limits of local administration of IL-12 gene, we constructed a polymersome system for systemic delivery of recombinant murine IL-12 plasmid (pmIL-12) based on amphiphilic polyphosphazenes containing weakly cationic N,N-diisopropylethylenediamine (DPA) as hydrophobic groups and monomethoxy poly(ethylene glycol) (mPEG) as hydrophilic tails. By simple dialysis method, pmIL-12 was successfully loaded into polymersomes due to the combination effect of physical encapsulation and electrostatic interaction...
June 13, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27188928/the-usefulness-of-neutrophil-cd64-expression-for-diagnosing-infection-after-orthopaedic-surgery-in-dialysis-patients
#18
Toru Doi, Tokuhide Doi, Naohiro Kawamura, Toshihiro Matsui, Akiko Komiya, Zaika Tei, Gaku Niitsuma, Junichi Kunogi
BACKGROUND: Dialysis patients undergoing orthopaedic surgery are at high risk for postoperative infection. Diagnosis of postoperative infection is difficult in dialysis patients due to presentation of signs and symptoms similar to infection, such as fever and elevated inflammatory marker levels. Neutrophil CD64 expression (CD64), a marker of infection, is upregulated by microbial wall components and several cytokines (interferon-γ and tumor necrosis factor-α). The purpose of this study is to evaluate the usefulness of CD64 for diagnosing postoperative infection in dialysis patients post orthopaedic surgery...
July 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27153924/i%C3%AE%C2%BAb-kinase-inhibitor-attenuates-sepsis-induced-cardiac-dysfunction-in-ckd
#19
Jianmin Chen, Julius E Kieswich, Fausto Chiazza, Amie J Moyes, Thomas Gobbetti, Gareth S D Purvis, Daniela C F Salvatori, Nimesh S A Patel, Mauro Perretti, Adrian J Hobbs, Massimo Collino, Muhammad M Yaqoob, Christoph Thiemermann
Patients with CKD requiring dialysis have a higher risk of sepsis and a 100-fold higher mortality rate than the general population with sepsis. The severity of cardiac dysfunction predicts mortality in patients with sepsis. Here, we investigated the effect of preexisting CKD on cardiac function in mice with sepsis and whether inhibition of IκB kinase (IKK) reduces the cardiac dysfunction in CKD sepsis. Male C57BL/6 mice underwent 5/6 nephrectomy, and 8 weeks later, they were subjected to LPS (2 mg/kg) or sepsis by cecal ligation and puncture (CLP)...
May 6, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27068711/poems-syndrome-and-calciphylaxis-an-unrecognized-cause-of-abnormal-small-vessel-calcification
#20
REVIEW
Nobuyuki Araki, Sonoko Misawa, Kazumoto Shibuya, Satoshi Ota, Takashi Oide, Asuka Kawano, Minako Beppu, Yukio Nakatani, Satoshi Kuwabara
BACKGROUND: Calciphylaxis is a syndrome consisting of vascular calcification, thrombosis, and skin necrosis. The syndrome develops often in chronic hemodialysis patients. However, there have been several case reports on calciphylaxis in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, a systemic disease associated with plasma cell dyscrasia and upregulation of vascular endothelial growth factor (VEGF). METHODS: In 76 POEMS patients and 86 age- and gender-matched disease controls, we studied abnormal small vessel calcification by computed tomography (CT) of the soft tissues...
2016: Orphanet Journal of Rare Diseases
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