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https://www.readbyqxmd.com/read/28740768/fmri-after-phalloplasty-with-nerve-anastomosis-in-a-trans-man-patient
#1
Roberto Doria-Medina, Åsa Carlsson, Emma H Jönsson, Lars Jönsson, Andri Thorarinsson, Mattias Lidén, Gennaro Selvaggi
We report on a case of a trans-man patient, who underwent penile reconstruction with the use of a radial forearm flap, urethroplasty, vaginectomy and scrotoplasty, insertion of testicle implants, and penile erection implants, similar to previously described methods. One of the requirements for an ideal phalloplasty is the preservation of erogenous sensitivity, which is often demanded by the patients for fulfilling their sexual well-being. For the first time known to us, we use a functional magnetic resonance imaging following radial forearm flap phalloplasty with nerve anastomosis to assess the cortical activation after clitoral stimulation...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28738216/early-time-related-course-of-image-findings-in-postmortem-mri-typical-findings-and-observer-agreement-in-a-porcine-model
#2
Frank Oliver Henes, Marc Regier, Peter Bannas, Marlen Henker, Axel Heinemann, Jan Sperhake, Philipp G C Begemann, Gerhard Adam, Michael Groth
PURPOSE: To assess early time-related image findings in postmortem magnetic resonance imaging (MRI) and to evaluate observer agreement in a porcine model. MATERIAL AND METHODS: Three pigs were examined by MRI at 15 different time points in the first 36h after death. Two observers independently recorded the postmortem interval (PMI) to the appearance of fluid collection (pleural space, interlobar and interlobular pulmonary fissures and hepatic interlobar fissures), gas accumulation (intrahepatic and intracardial) and blood clotting (aorta and intrahepatic venous vessels)...
July 15, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28738189/surgical-landmarks-to-locating-the-main-trunk-of-the-facial-nerve-in-parotid-surgery-a-systematic-review
#3
Yisi D Ji, R Bruce Donoff, Zachary S Peacock, Eric R Carlson
PURPOSE: The purpose of this study was to describe distances from commonly used anatomic landmarks to the main trunk of the facial nerve during parotid surgery. MATERIALS AND METHODS: A systematic search of the published literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies from January 1, 1990 to January 1, 2017 that measured distances to the main trunk of the facial nerve from common anatomic landmarks were eligible...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28735298/foxp1-related-intellectual-disability-syndrome-a-recognisable-entity
#4
Ilse Meerschaut, Daniel Rochefort, Nicole Revençu, Justine Pètre, Christina Corsello, Guy A Rouleau, Fadi F Hamdan, Jacques L Michaud, Jenny Morton, Jessica Radley, Nicola Ragge, Sixto García-Miñaúr, Pablo Lapunzina, Maria Palomares Bralo, Maria Ángeles Mori, Stéphanie Moortgat, Valérie Benoit, Sandrine Mary, Nele Bockaert, Ann Oostra, Olivier Vanakker, Milen Velinov, Thomy Jl de Ravel, Djalila Mekahli, Jonathan Sebat, Keith K Vaux, Nataliya DiDonato, Andrea K Hanson-Kahn, Louanne Hudgins, Bruno Dallapiccola, Antonio Novelli, Luigi Tarani, Joris Andrieux, Michael J Parker, Katherine Neas, Berten Ceulemans, An-Sofie Schoonjans, Darina Prchalova, Marketa Havlovicova, Miroslava Hancarova, Magdalena Budisteanu, Annelies Dheedene, Björn Menten, Patrick A Dion, Damien Lederer, Bert Callewaert
BACKGROUND: Mutations in forkhead box protein P1 (FOXP1) cause intellectual disability (ID) and specific language impairment (SLI), with or without autistic features (MIM: 613670). Despite multiple case reports no specific phenotype emerged so far. METHODS: We correlate clinical and molecular data of 25 novel and 23 previously reported patients with FOXP1 defects. We evaluated FOXP1 activity by an in vitro luciferase model and assessed protein stability in vitro by western blotting...
July 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28735140/isolated-subcallosal-artery-infarction-secondary-to-localised-cerebral-vasospasm-of-anterior-communicating-artery-complex-following-subarachnoid-haemorrhage
#5
Santhosh Kumar Kannath, Virender Malik, Jayadevan Enakshy Rajan
BACKGROUND: Subcallosal artery (ScA) infarction is a well-recognised, but uncommon complication of surgical treatment of anterior communicating artery (ACOM) aneurysms. CASE DESCRIPTION: An elderly man presented with massive subarachnoid haemorrhage due to left posterior communicating artery aneurysm with thick clots in the anterior interhemispheric fissure. The aneurysm was coiled with balloon protection and later, on the fifth day of ictus, the patient became acutely confused and developed memory disturbances...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28731017/methotrexate-iontophoresis-versus-coal-tar-ointment-in-palmoplantar-psoriasis-a-pilot-study
#6
K Haseena, Sandhya George, Najeeba Riyaz, Sarita Sasidharanpillai, Paul V Puthussery
BACKGROUND: Palmoplantar psoriasis is often disabling and refractory to conventional therapy. Systemic drugs are indicated in its severe form, but side effects are a concern with their use. Methotrexate is one such systemic drug which is effective and cheap. To reduce systemic toxicity, methotrexate has been tried topically but results have been inconsistent due to poor drug penetration into the skin by passive diffusion. Iontophoresis may enhance its absorption and efficacy. AIM: To evaluate the efficacy and safety of topical methotrexate iontophoresis in comparison with coal tar ointment in the treatment of palmoplantar psoriasis...
July 20, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28729440/the-transcription-factor-foxg1-promotes-optic-fissure-closure-in-the-mouse-by-suppressing-wnt8b-in-the-nasal-optic-stalk
#7
Rowena Smith, Yu-Ting Huang, Tian Tian, Dominika Vojtasova, Oscar Mesalles-Naranjo, Steven M Pollard, Thomas Pratt, David J Price, Vassiliki Fotaki
During vertebrate eye morphogenesis a transient fissure forms at its inferior part, known as the optic fissure. This will gradually close giving rise to a healthy, spherical optic cup. Failure of the optic fissure to close gives rise to an ocular disorder known as coloboma. During this developmental process Foxg1 is expressed in the optic neuroepithelium, with highest levels of expression in the nasal optic stalk. Foxg1-/- mutant mice have microphthalmic eyes with a large ventral coloboma. We found Wnt8b expression upregulated in the Foxg1-/- optic stalk and hypothesized that, similar to what is observed in telencephalic development, Foxg1 directs development of the optic neuroepithelium through transcriptional suppression of Wnt8b To test this, we generated Foxg1-/-;Wnt8b-/- double mutants of either sex and found that the morphology of the optic cup and stalk and the closure of the optic fissure were substantially rescued in these embryos...
July 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28722216/primary-pulmonary-myxoid-sarcoma-located-in-interlobar-fissure-without-parenchymal-invasion
#8
Seok Kim, Sang Yun Song, Ju Sik Yun, Yoo Duk Choi, Kook Joo Na
Primary pulmonary myxoid sarcoma (PPMS), classified as low to intermediate grade malignant myxoid endobronchial tumor, is rarely reported. Most reported cases occurred in lung parenchyme with an endobronchial component. Herein, we report a case of PPMS in a 29-year-old woman that developed in a major fissure of the left lung without parenchymal invasion. Histopathologically, the diagnosis was compatible to PPMS with EWSR1-CREB1 translocation.
July 19, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28718248/outcome-of-0-2-glyceryltrinitrate-cream-versus-2-diltiazem-cream-in-the-treatment-of-chronic-anal-fissure
#9
Muhammad Siddique Khan, Ismail Akbar, Junaid Zeb, Salman Ahmad, Ajmal Khan
BACKGROUND: Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. METHODS: This randomized controlled trial (RCT) was carried out in the Department of Surgical "B" unit, at Ayub Teaching Hospital, Abbottabad, Pakistan from 15th June 2012 to 15th May 2015...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28713632/radiographic-assessment-of-the-presigmoid-retrolabyrinthine-approach
#10
Andrew K Wong, Melissa M Stamates, Anita P Bhansali, Michael Shinners, Ricky H Wong
BACKGROUND: Lesions of the petroclival fissure are difficult to access surgically. Both retrosigmoid and presigmoid retrolabyrinthine approaches have been described to successfully treat these complex tumors. The retrosigmoid approach offers quick and familiar access, whereas the presigmoid retrolabyrinthine approach reduces the operative distance and the need for cerebellar retraction. The presigmoid retrolabyrinthine approach, however, is constrained by anatomical limits that can be subject to patient variation...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28709049/idiopathic-spontaneous-pulmonary-torsion-of-the-lingula-a-case-report
#11
Masatoshi Kanayama, Toshihiro Osaki, Natsumasa Nishizawa, Makoto Nakagawa, Tomoko So, Mantaro Kodate
INTRODUCTION: Spontaneous pulmonary torsion is an extremely rare event and is known to occur as a complication of thoracic surgery and traumatic injuries. PRESENTATION OF CASE: An 18-year-old man presented to our hospital with pain in the left back region. Clinical examination, computed tomography and bronchoscopy are crucial for diagnosis of pulmonary torsion. During thoracotomy, the lingula segment was observed to be bent on the head side and turned 180° counterclockwise; subsequently, lingulectomy was performed...
June 29, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28705505/physicochemical-properties-in-vitro-digestibility-and-structural-elucidation-of-rs4-from-rice-starch
#12
Bilal Ahmad Ashwar, Navreen Jan, Adil Gani, Asima Shah, Farooq Ahmad Masoodi
Starches extracted from four different rice cultivars were phosphorylated by using STMP/STPP (sodium trimetasulphate/sodium tripolyphosphate) to make modified food starches with high contents of type 4 resistant starch (RS4). The results revealed 10- fold improvement in RS4 content by the phosphorylation of starch. The phosphorus % and DS values of rice starches ranged from 0.33 to 0.35, and 0.016 to 0.018, respectively. FT-IR spectroscopy showed reduction of OH stretching band at 3290cm(-1) and the appearance of P=O at 1244-1266cm(-1) which confirms crosslinking of starch with STMP/STPP...
July 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28703180/socioeconomic-inequality-in-the-provision-of-specific-preventive-dental-interventions-among-children-in-the-uk-children-s-dental-health-survey-2003
#13
R Shaban, S Kassim, W Sabbah
Aim To assess socioeconomic inequality regarding specific preventive interventions (fissure sealants or any treatment to prevent caries) and dental visits among UK children.Method Data were from the Children's Dental Health Survey 2003, which included participants from England, Wales, Scotland, and Northern Ireland. The number of children in the analysis was 2,286. Variables were sex, age, area of residency (for example, England), mother's education, family social class, and deprivation level. Descriptive and regression analyses were performed...
June 9, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28701639/synthesized-mesoporous-silica-and-calcium-aluminate-cement-fillers-increased-the-fluoride-recharge-and-lactic-acid-neutralizing-ability-of-a-resin-based-pit-and-fissure-sealant
#14
Atikom Surintanasarn, Krisana Siralertmukul, Niyom Thamrongananskul
This study evaluated the effect of different types of filler in a resin-based pit and fissure sealant on fluoride release, recharge, and lactic acid neutralization. Resin-based sealant was incorporated with 5% w/w of the following fillers: calcium aluminate cement (CAC), synthesized mesoporous silica (SI), a CAC and SI mixture (CAC+SI), glass-ionomer powder (GIC), and acetic acid-treated GIC (GICA). Sealant without filler served as control. The samples were immersed in deionized water or a lactic acid solution and the concentration of fluoride in the water, before and after fluoride recharge, and the lactic acid pH change, respectively, were determined...
July 12, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28701637/retention-and-caries-preventive-effect-of-glass-ionomer-and-resin-based-sealants-an-18-month-randomized-clinical-trial
#15
Asma Al-Jobair, Nouf Al-Hammad, Salwa Alsadhan, Fouad Salama
The objective of this study was to compare the retention and caries-preventive effect of glass ionomer (Fuji Triage) and resin-based (Clinpro) sealants among 6-9-year-old children. This split-mouth, randomized clinical trial covered 35 children/140 fully erupted permanent first molars. Evaluation was conducted by two independent examiners after 6, 12, and 18 months and the data were compared in relation to the children's caries risk and age groups. The Kaplan-Meier survival method and chi-square test were used for analysis...
July 12, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28701263/treatment-for-anal-fissure-is-there-a-safe-option
#16
Justin T Brady, Alison R Althans, Ruel Neupane, Eslam M G Dosokey, Murad A Jabir, Harry L Reynolds, Scott R Steele, Sharon L Stein
BACKGROUND: Surgeons often approach anal fissure with chemical denervation (Botulinum toxin, BT) instead of initial lateral internal sphincterotomy (LIS) due to concerns for long-term incontinence. We evaluated the characteristics and outcomes of patients who received BT or LIS. METHODS: We performed a retrospective chart review of patients undergoing LIS and BT for anal fissure between 2009 and 2015. In 2015, a telephone survey was performed to evaluate durability, long-term incontinence and patient satisfaction...
July 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28698090/the-superior-frontal-transsulcal-approach-to-the-anterior-ventricular-system-exploring-the-sulcal-and-subcortical-anatomy-using-anatomic-dissections-and-dti-tractography
#17
Christos Koutsarnakis, Faidon Liakos, Aristotelis V Kalyvas, Georgios P Skandalakis, Spyros Komaitis, Fotini Christidi, Efstratios Karavasilis, Evangellia Liouta, George Stranjalis
OBJECTIVE: To explore the superior frontal sulcus morphology, trajectory of the applied surgical corridor and white matter bundles that are traversed during the superior frontal transsulcal transventricular approach METHODS: Twenty (20) normal, adult, formalin-fixed cerebral hemispheres and two (2) cadaveric heads were included in the study. The superior frontal sulcus (SFS) topography, morphology and dimensions were recorded in all specimens. Fourteen (14) hemispheres were investigated through the fiber dissection technique while the remaining six (6) were explored using coronal cuts...
July 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28696035/lin-gettig-syndrome-craniosynostosis-expands-the-spectrum-of-the-kat6b-related-disorders
#18
Rani A Bashir, Abhijit Dixit, Caitlin Goedhart, Jillian S Parboosingh, Allan M Innes, Patrick Ferreira, Shabih U Hasan, Ping-Yee B Au
We report two patients with sagittal craniosynostosis, hypoplastic male genitalia, agenesis of the corpus callosum, thyroid abnormalities, and dysmorphic features which include short palpebral fissures and retrognathia. The clinical presentation of both patients was initially thought to be suggestive of Lin-Gettig syndrome (LGS), a multiple malformation syndrome associated with craniosynostosis that was initially reported in two brothers in 1990, with a third patient reported in 2003. Our first patient was subsequently found through exome sequencing to have a de novo mutation in KAT6B, c...
July 11, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28690535/femtosecond-laser-in-situ-keratomileusis-flap-creation-in-narrow-palpebral-fissure-eyes-without-suction
#19
John S M Chang, Antony K P Law, Jack C M Ng, May S Y Cheng
PURPOSE: To evaluate a surgical technique used in eyes with narrow palpebral fissure undergoing femtosecond laser flap creation without suction during laser in situ keratomileusis (LASIK). METHODS: All data of 2 patient groups were collected through chart review. Group 1 consisted of 6 eyes with narrow palpebral fissure in which the suction ring was manually fixated and femtosecond laser was applied accordingly. Thirty comparison cases were randomly drawn from among eyes that underwent a standard LASIK procedure matched for age and preoperative refraction (group 2)...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28689736/zebrafish-zic2-controls-formation-of-periocular-neural-crest-and-choroid-fissure-morphogenesis
#20
Irina Sedykh, Baul Yoon, Laura Roberson, Oleg Moskvin, Colin N Dewey, Yevgenya Grinblat
The vertebrate retina develops in close proximity to the forebrain and neural crest-derived cartilages of the face and jaw. Coloboma, a congenital eye malformation, is associated with aberrant forebrain development (holoprosencephaly) and with craniofacial defects (frontonasal dysplasia) in humans, suggesting a critical role for cross-lineage interactions during retinal morphogenesis. ZIC2, a zinc-finger transcription factor, is linked to human holoprosencephaly. We have previously used morpholino assays to show zebrafish zic2 functions in the developing forebrain, retina and craniofacial cartilage...
July 6, 2017: Developmental Biology
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