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ESRD microbiota

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https://www.readbyqxmd.com/read/27829988/targeting-gut-microbiota-a-potential-promising-therapy-for-diabetic-kidney-disease
#1
REVIEW
Zhonge Chen, Shuishan Zhu, Gaosi Xu
Conventional studies reveal a contributory role of gut microbiota in the process of diabetes mellitus (DM) and end-stage renal disease (ESRD). However, the mechanism through which gut microbiota influence diabetic kidney disease (DKD) is ignored. In the present article, we reviewed the changes in gut microbiota of patients with DM, DKD as well as ESRD, and how this may contribute to the progression of DKD. Although further studies are needed to either selectively change the composition of the gut microbiota or to pharmacologically control the metabolites of microbiota, the gut microbiota represents a new potential therapeutic target for DKD...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27660122/fatty-liver-and-chronic-kidney-disease-novel-mechanistic-insights-and-therapeutic-opportunities
#2
REVIEW
Giovanni Musso, Maurizio Cassader, Solomon Cohney, Franco De Michieli, Silvia Pinach, Francesca Saba, Roberto Gambino
Chronic kidney disease (CKD) is a risk factor for end-stage renal disease (ESRD) and cardiovascular disease (CVD). ESRD or CVD develop in a substantial proportion of patients with CKD receiving standard-of-care therapy, and mortality in CKD remains unchanged. These data suggest that key pathogenetic mechanisms underlying CKD progression go unaffected by current treatments. Growing evidence suggests that nonalcoholic fatty liver disease (NAFLD) and CKD share common pathogenetic mechanisms and potential therapeutic targets...
October 2016: Diabetes Care
https://www.readbyqxmd.com/read/27640125/intestinal-microbiota-in-pediatric-patients-with-end-stage-renal-disease-a-midwest-pediatric-nephrology-consortium-study
#3
Janice Crespo-Salgado, V Matti Vehaskari, Tyrus Stewart, Michael Ferris, Qiang Zhang, Guangdi Wang, Eugene E Blanchard, Christopher M Taylor, Mahmoud Kallash, Larry A Greenbaum, Diego H Aviles
BACKGROUND: End-stage renal disease (ESRD) is associated with uremia and increased systemic inflammation. Alteration of the intestinal microbiota may facilitate translocation of endotoxins into the systemic circulation leading to inflammation. We hypothesized that children with ESRD have an altered intestinal microbiota and increased serum levels of bacterially derived uremic toxins. METHODS: Four groups of subjects were recruited: peritoneal dialysis (PD), hemodialysis (HD), post-kidney transplant and healthy controls...
September 17, 2016: Microbiome
https://www.readbyqxmd.com/read/25339487/cardiovascular-disease-and-its-relationship-with-chronic-kidney-disease
#4
REVIEW
M Liu, X-C Li, L Lu, Y Cao, R-R Sun, S Chen, P-Y Zhang
Cardiovascular disease (CVD), the leading cause of death, is mostly precipitated by cardiometabolic risk and chronic kidney disease (CKD). CVD and kidney disease are closely interrelated and disease of one organ cause dysfunction of the other, ultimately leading to the failure of both organs. Patients with end-stage renal disease (ESRD) are at much higher risk of mortality due to CVD. Traditional CVD risk factors viz., hypertension, hyperlipidemia, and diabetes do not account for the high cardiovascular risk in CKD patients and also standard clinical interventions for managing CVD that are successful in the general population, are ineffective to lower the death rate in CKD patients...
October 2014: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25066654/effects-of-a-symbiotic-on-gut-microbiota-in-mexican-patients-with-end-stage-renal-disease
#5
RANDOMIZED CONTROLLED TRIAL
José Cruz-Mora, Norma E Martínez-Hernández, Fabiola Martín del Campo-López, Daniela Viramontes-Hörner, Bárbara Vizmanos-Lamotte, José F Muñoz-Valle, Guillermo García-García, Isela Parra-Rojas, Natividad Castro-Alarcón
OBJECTIVES: Gut microbiota provides beneficial effects under physiological conditions, but is able to contribute to inflammatory diseases in susceptible individuals. Thus, we designed this study to test whether additional intake of symbiotic gel affects specific modifications of gut microbiota in patients with end-stage renal disease (ESRD). METHODS: Eighteen patients with ESRD diagnosis with renal replacement therapy (hemodialysis) were included in this study. They were randomly assigned to 2 treatment groups: (1) test group (nutritional counseling + symbiotic) and (2) control group (nutritional counseling + placebo)...
September 2014: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/25038737/gut-microbial-translocation-in-the-pathogenesis-of-systemic-inflammation-in-patients-with-end-stage-renal-disease
#6
EDITORIAL
Nosratola D Vaziri
No abstract text is available yet for this article.
September 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24994892/galacto-oligosaccharides-attenuate-renal-injury-with-microbiota-modification
#7
Satoshi U Furuse, Takamoto Ohse, Airi Jo-Watanabe, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku
Tubulointerstitial injury is central to the progression of end-stage renal disease. Recent studies have revealed that one of the most investigated uremic toxins, indoxyl sulfate (IS), caused tubulointerstitial injury through oxidative stress and endoplasmic reticulum (ER) stress. Because indole, the precursor of IS, is synthesized from dietary tryptophan by the gut microbiota, we hypothesized that the intervention targeting the gut microbiota in kidney disease with galacto-oligosaccharides (GOS) would attenuate renal injury...
July 1, 2014: Physiological Reports
https://www.readbyqxmd.com/read/24828917/gut-bacterial-translocation-may-aggravate-microinflammation-in-hemodialysis-patients
#8
Kehui Shi, Feiqian Wang, Hongli Jiang, Hua Liu, Meng Wei, Zhigang Wang, Li Xie
BACKGROUND/AIMS: Bacterial translocation (BT) promotes microinflammation in predialysis patients with end-stage renal disease (ESRD). However, the change in BT has not been reported in ESRD patients undergoing regular hemodialysis treatment. The present study investigated whether hemodialysis promotes gut BT and microinflammation. METHODS: The blood, gut, and dialysate of hemodialysis patients were analyzed using bacterial 16S rDNA amplification and DNA pyrosequencing to determine the presence of bacteria and alteration in gut microbiomes...
September 2014: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/24643131/expansion-of-urease-and-uricase-containing-indole-and-p-cresol-forming-and-contraction-of-short-chain-fatty-acid-producing-intestinal-microbiota-in-esrd
#9
Jakk Wong, Yvette M Piceno, Todd Z Desantis, Madeleine Pahl, Gary L Andersen, Nosratola D Vaziri
BACKGROUND: Intestinal microbiome constitutes a symbiotic ecosystem that is essential for health, and changes in its composition/function cause various illnesses. Biochemical milieu shapes the structure and function of the microbiome. Recently, we found marked differences in the abundance of numerous bacterial taxa between ESRD and healthy individuals. Influx of urea and uric acid and dietary restriction of fruits and vegetables to prevent hyperkalemia alter ESRD patients' intestinal milieu...
2014: American Journal of Nephrology
https://www.readbyqxmd.com/read/23325079/the-intestinal-microbiota-a-leaky-gut-and-abnormal-immunity-in-kidney-disease
#10
REVIEW
Hans-Joachim Anders, Kirstin Andersen, Bärbel Stecher
Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are associated with systemic inflammation and acquired immunodeficiency, which promote cardiovascular disease, body wasting, and infections as leading causes of death. This phenomenon persists despite dialysis-related triggers of immune deregulation having been largely eliminated. Here we propose a potential immunoregulatory role of the intestinal microbiota in CKD/ESRD. We discuss how the metabolic alterations of uremia favor pathogen overgrowth (dysbiosis) in the gut and an increased translocation of living bacteria and bacterial components...
June 2013: Kidney International
https://www.readbyqxmd.com/read/17305623/periodontal-and-oral-microbiological-status-of-an-adult-population-undergoing-haemodialysis-a-cross-sectional-study
#11
COMPARATIVE STUDY
A Castillo, F Mesa, J Liébana, O García-Martinez, S Ruiz, J García-Valdecasas, F O'Valle
OBJECTIVES: The aim of this cross-sectional study was to evaluate the periodontal status and oral microbiological patterns of a population with end-stage renal disease (ESRD), undergoing haemodialysis (HD). DESIGN: This was a cross-sectional study, involving 52 patients from the Nephrology Department and 52 matched control subjects. MATERIALS AND METHODS: The subjects had a periodontal clinical examination; subgingival plaque samples were taken and analysed using a semiquantitative polymerase chain reaction (PCR) test to detect Porphyromas gingivalis, Tannerella forsythia, Prevotella intermedia, Prevotella nigrescens and Actinobacillus actinomycetemcomitans...
March 2007: Oral Diseases
https://www.readbyqxmd.com/read/16436893/in-vitro-and-in-vivo-assessment-of-intraintestinal-bacteriotherapy-in-chronic-kidney-disease
#12
COMPARATIVE STUDY
Natarajan Ranganathan, Beena G Patel, Pari Ranganathan, Joseph Marczely, Rahul Dheer, Bohdan Pechenyak, Stephen R Dunn, Willy Verstraete, Karel Decroos, Raj Mehta, Eli A Friedman
Chronic kidney disease may progress to end-stage renal disease, which requires dialysis or kidney transplantation. No generally applicable therapies to slow progression of renal disease are available. Bacteriotherapy affords a promising approach to mitigate uremic intoxication by ingestion of live microbes able to catabolize uremic solutes in the gut. The present study evaluates the nonpathogenic soil-borne alkalophilic urease-positive bacterium Sporosarcina pasteurii (Sp) as a potential urea-targeted component for such "enteric dialysis" formulation...
January 2006: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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