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https://www.readbyqxmd.com/read/29156182/obesity-pharmacotherapy
#1
REVIEW
Katherine H Saunders, Devika Umashanker, Leon I Igel, Rekha B Kumar, Louis J Aronne
Although diet, physical activity, and behavioral modifications are the cornerstones of weight management, weight loss achieved by lifestyle modifications alone is often limited and difficult to maintain. Pharmacotherapy for obesity can be considered if patients have a body mass index (BMI) of 30 kg/m(2) or greater or BMI of 27 kg/m(2) or greater with weight-related comorbidities. The 6 most commonly used antiobesity medications are phentermine, orlistat, phentermine/topiramate extended release, lorcaserin, naltrexone sustained release (SR)/bupropion SR, and liraglutide 3...
January 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29110192/endoscopic-sleeve-gastroplasty-laparoscopic-sleeve-gastrectomy-and-laparoscopic-band-for-weight-loss-how-do-they-compare
#2
Aleksey A Novikov, Cheguevara Afaneh, Monica Saumoy, Viviana Parra, Alpana Shukla, Gregory F Dakin, Alfons Pomp, Enad Dawod, Shawn Shah, Louis J Aronne, Reem Z Sharaiha
BACKGROUND: Endoscopic sleeve gastroplasty (ESG) is a novel endobariatric procedure. Initial studies demonstrated an association of ESG with weight loss and improvement of obesity-related comorbidities. Our aim was to compare ESG to laparoscopic sleeve gastrectomy (LSG) and laparoscopic adjustable gastric banding (LAGB). METHODS: We included 278 obese (BMI > 30) patients who underwent ESG (n = 91), LSG (n = 120), or LAGB (n = 67) at our tertiary care academic center...
November 6, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28991935/obesity-when-to-consider-medication
#3
REVIEW
Katherine H Saunders, Alpana P Shukla, Leon I Igel, Louis J Aronne
These 4 cases illustrate how weight loss drugs--including the 4 newest--can be integrated into a treatment plan that includes diet, exercise, and behavior modification.
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28989726/carbohydrate-last-meal-pattern-lowers-postprandial-glucose-and-insulin-excursions-in-type-2-diabetes
#4
Alpana P Shukla, Jeselin Andono, Samir H Touhamy, Anthony Casper, Radu G Iliescu, Elizabeth Mauer, Yuan Shan Zhu, David S Ludwig, Louis J Aronne
BACKGROUND: There are limited data regarding the timing of carbohydrate ingestion during a meal and postprandial glucose regulation. METHODS: Sixteen subjects with type 2 diabetes mellitus (T2DM) consumed the same meal on 3 days in random order: carbohydrate first, followed 10 min later by protein and vegetables; protein and vegetables first, followed 10 min later by carbohydrate; or all components together. Blood was sampled for glucose, insulin, glucagon-like peptide-1 (GLP-1), and glucagon measurements at baseline (just before meal ingestion) and subsequently at 30 min intervals up to 180 min...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28950422/liraglutide-and-cardiovascular-outcomes-in-adults-with-overweight-or-obesity-a-post-hoc-analysis-from-scale-randomized-controlled-trials
#5
M J Davies, L J Aronne, I D Caterson, A B Thomsen, P B Jacobsen, S P Marso
The cardiovascular safety of liraglutide, a glucagon-like peptide-1 receptor agonist approved for weight management at a dose of 3.0 mg, was evaluated post hoc using data from 5908 participants in 5 randomized, double-blind, placebo-controlled clinical trials. Participants were randomized to liraglutide or a comparator group (placebo or orlistat). The objective was to evaluate whether cardiovascular risk was increased with liraglutide treatment. The primary composite outcome of this time-to-event analysis was the first occurrence of cardiovascular death, nonfatal myocardial infarction or nonfatal stroke...
September 26, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28843586/a-single-operator-learning-curve-analysis-for-the-endoscopic-sleeve-gastroplasty
#6
Monica Saumoy, Yecheskel Schneider, Xi Kathy Zhou, Alpana Shukla, Michel Kahaleh, Louis Aronne, Reem Z Sharaiha
BACKGROUND AND AIMS: Endoscopic sleeve gastroplasty (ESG) is a novel, incisionless technique for gastric volume reduction to promote weight loss. Our aim was to describe the learning curve for performing ESG using a prospective case series. METHODS: Using a prospective case series design, we analyzed the first 128 consecutive patients at a tertiary care academic medical center who underwent ESG performed by a single operator from August 2013 to December 2016. Efficiency (refining performance to decrease procedure time) and mastery (absence of outliers) for performing ESG was evaluated by using a penalized basis-spline regression and cumulative sum analysis...
August 24, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28789868/space-time-mesh-adaptation-for-solute-transport-in-randomly-heterogeneous-porous-media
#7
Aronne Dell'Oca, Giovanni Michele Porta, Alberto Guadagnini, Monica Riva
We assess the impact of an anisotropic space and time grid adaptation technique on our ability to solve numerically solute transport in heterogeneous porous media. Heterogeneity is characterized in terms of the spatial distribution of hydraulic conductivity, whose natural logarithm, Y, is treated as a second-order stationary random process. We consider nonreactive transport of dissolved chemicals to be governed by an Advection Dispersion Equation at the continuum scale. The flow field, which provides the advective component of transport, is obtained through the numerical solution of Darcy's law...
July 5, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28660593/is-obesity-the-new-hypertension-parallels-in-the-evolution-of-obesity-and-hypertension-as-recognized-disease-states
#8
REVIEW
Devika Umashanker, Alpana P Shukla, Katherine H Saunders, Louis J Aronne
Obesity and hypertension are recognized disease states that share many similarities including complex physiology, therapeutic response to both lifestyle modification and pharmacotherapy, and the need for long-term management. Both were initially believed to be disorders of lifestyle rather than true disease entities, and initial efforts at developing medical and surgical therapies were criticized. Ultimately, both have proven to be amenable to treatments that control their underlying physiology. Both hypertension and obesity have complex pathophysiology involving multiple regulatory pathways that may require combination therapies in addition to lifestyle modification to reach therapeutic goals...
August 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28544791/the-american-board-of-obesity-medicine-five-year-report
#9
Robert F Kushner, Dana Brittan, John Cleek, Dyan Hes, Wayne English, Scott Kahan, Louis J Aronne
No abstract text is available yet for this article.
June 2017: Obesity
https://www.readbyqxmd.com/read/28529515/changes-in-leaf-anatomical-traits-enhanced-photosynthetic-activity-of-soybean-grown-in-hydroponics-with-plant-growth-promoting-microorganisms
#10
Roberta Paradiso, Carmen Arena, Veronica De Micco, Maria Giordano, Giovanna Aronne, Stefania De Pascale
The use of hydroponic systems for cultivation in controlled climatic conditions and the selection of suitable genotypes for the specific environment help improving crop growth and yield. We hypothesized that plant performance in hydroponics could be further maximized by exploiting the action of plant growth-promoting organisms (PGPMs). However, the effects of PGPMs on plant physiology have been scarcely investigated in hydroponics. Within a series of experiments aimed to identify the best protocol for hydroponic cultivation of soybean [Glycine max (L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28451929/endoscopic-sleeve-gastroplasty-for-obesity-a-multicenter-study-of-248-patients-with-24%C3%A2-months-follow-up
#11
Gontrand Lopez-Nava, Reem Z Sharaiha, Eric J Vargas, Fateh Bazerbachi, Galvao Neto Manoel, Inmaculada Bautista-Castaño, Andres Acosta, Mark D Topazian, Manpreet S Mundi, Nikhil Kumta, Michel Kahaleh, Andrea Marie Herr, Alpana Shukla, Louis Aronne, Christopher J Gostout, Barham K Abu Dayyeh
BACKGROUND: Endoscopic sleeve gastroplasty (ESG) is a technique for managing mild to moderately obese patients. We aimed to evaluate the long-term outcomes, reproducibility, and predictors of weight response in a large multicenter cohort. METHODS: Patients who underwent ESG between January 2013 and December 2015 in three centers were retrospectively analyzed. All procedures were performed using the Apollo OverStitch device (Apollo Endosurgery, Austin, TX). We performed per protocol (PP) and intention-to-treat (ITT) analyses, where patients lost to follow-up were considered failures...
October 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28440045/coadministration-of-lorcaserin-and-phentermine-for-weight-management-a-12-week-randomized-pilot-safety-study
#12
Steven R Smith, W Timothy Garvey, Frank L Greenway, Sharon Zhou, Randi Fain, Robert Pilson, Ken Fujioka, Louis J Aronne
OBJECTIVE: To assess the short-term tolerability of lorcaserin alone or with two dose regimens of phentermine. METHODS: This was a 12-week, randomized, double-blind, pilot safety study of N = 238 nondiabetic patients with obesity or overweight with ≥1 comorbidity randomized to lorcaserin 10 mg twice daily (BID; LOR BID) alone or with phentermine 15 mg once daily (QD; LOR BID+PHEN QD) or 15 mg twice daily (LOR BID+PHEN BID). Patients reporting ≥ 1 of 9 potentially serotonergic adverse events (AEs), mean weight loss (WL), and ≥5% WL are reported...
May 2017: Obesity
https://www.readbyqxmd.com/read/28371396/use-of-lorcaserin-for-glycemic-control-in-patients-with-type-2-diabetes-mellitus
#13
Leon I Igel, Louis J Aronne
No abstract text is available yet for this article.
May 2017: Obesity
https://www.readbyqxmd.com/read/28292399/current-and-future-medical-treatment-of-obesity
#14
REVIEW
Devika Umashanker, Leon I Igel, Rekha B Kumar, Louis J Aronne
Obesity is a major health crisis resulting in comorbidities such as hypertension, type 2 diabetes, and obstructive sleep apnea. The need for safe and efficacious drugs to help assist with weight loss and reduce cardiometabolic risk factors is great. With several FDA-approved drugs on the market, there is still a great need to develop long-term obesity treatments or noninvasive oral agents to help assist individuals with obesity when used in conjunction with lifestyle modifications.
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28271432/pharmacotherapy-for-weight-management-in-the-vha
#15
Todd P Semla, Chris Ruser, Chester B Good, Susan Z Yanovski, Donna Ames, Laurel A Copeland, Charles Billington, U Inge Ferguson, Louis J Aronne, Thomas A Wadden, W Timothy Garvey, Caroline M Apovian, David Atkins
Weight management medications (WMM) are underutilized as an adjunct to behavioral and lifestyle interventions. In fiscal years 2014-2015, a total of approximately 2500 veterans-a mere 2% of veterans receiving care from the Veterans Health Administration (VHA)-eligible for a WMM received a prescription for one. A State of the Art Conference on Weight Management workgroup, focused on pharmacotherapy, developed evidence-based recommendations and strategies to foster the appropriate use of WMM in the VHA. The workgroup identified patient, prescriber, and health system barriers to and facilitators for prescribing WMM...
April 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28242319/white-paper-aga-power-practice-guide-on-obesity-and%C3%A2-weight-management-education-and-resources
#16
REVIEW
Andres Acosta, Sarah Streett, Mathew D Kroh, Lawrence J Cheskin, Katherine H Saunders, Marina Kurian, Marsha Schofield, Sarah E Barlow, Louis Aronne
The epidemic of obesity continues at alarming rates, with a high burden to our economy and society. The American Gastroenterological Association understands the importance of embracing obesity as a chronic, relapsing disease and supports a multidisciplinary approach to the management of obesity. Because gastrointestinal disorders resulting from obesity are more frequent and often present sooner than type 2 diabetes mellitus and cardiovascular disease, gastroenterologists have an opportunity to address obesity and provide an effective therapy early...
May 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28192104/practical-use-of-pharmacotherapy-for-obesity
#17
REVIEW
Leon I Igel, Rekha B Kumar, Katherine H Saunders, Louis J Aronne
Obesity management requires a multidisciplinary approach, as there are many factors that contribute to the development of obesity, as well as the preservation of excess weight once it has been gained. Diet, exercise, and behavior modification are key components of treatment. In addition to lifestyle changes, weight gain secondary to medications is an important modifiable risk factor. Even after appropriate lifestyle modification, and medication adjustments (where possible) to avoid agents that can contribute to weight gain, many patients are still unable to achieve clinically meaningful weight loss...
May 2017: Gastroenterology
https://www.readbyqxmd.com/read/28087864/drug-induced-weight-gain-rethinking-our-choices
#18
REVIEW
Katherine H Saunders, Leon I Igel, Alpana P Shukla, Louis J Aronne
Weight gain secondary to medications is a potentially modifiable risk. Here's how to optimize drug choices for patients with several common conditions.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28033472/obesity-coverage-on-medical-licensing-examinations-in-the-united-states-what-is-being-tested
#19
Robert F Kushner, W Scott Butsch, Scott Kahan, Sriram Machineni, Stephen Cook, Louis J Aronne
Phenomenon. As one of the most common chronic disease affecting adults and children, obesity is a major contributor to noncommunicable diseases, both nationally and globally. Obesity adversely affects every organ system, and as such it is imperative that the United States Medical Licensing Examination (USMLE) adequately assesses students' knowledge about the science and practice of obesity management. The purpose of this study was to evaluate the coverage and distribution of obesity-related items on the three USMLE Step examinations...
April 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28017845/endoscopic-sleeve-gastroplasty-significantly-reduces-body-mass-index-and-metabolic-complications-in-obese-patients
#20
Reem Z Sharaiha, Nikhil A Kumta, Monica Saumoy, Amit P Desai, Alex M Sarkisian, Andrea Benevenuto, Amy Tyberg, Rekha Kumar, Leon Igel, Elizabeth C Verna, Robert Schwartz, Christina Frissora, Alpana Shukla, Louis J Aronne, Michel Kahaleh
BACKGROUND & AIMS: Endoscopic sleeve gastroplasty (ESG) is an incisionless, minimally invasive bariatric procedure that reduces the length and width of the gastric cavity to facilitate weight loss. We performed a prospective study to evaluate the effects of ESG on total body weight loss and obesity-related comorbidities. METHODS: We collected data from 91 consecutive patients (mean age, 43.86 ± 11.26 years; 68% female) undergoing ESG from August 2013 through March 2016...
April 2017: Clinical Gastroenterology and Hepatology
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