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https://www.readbyqxmd.com/read/29667157/devices-and-endoscopic-bariatric-therapies-for-obesity
#1
REVIEW
Katherine H Saunders, Leon I Igel, Monica Saumoy, Reem Z Sharaiha, Louis J Aronne
PURPOSE OF REVIEW: In this review, we describe the FDA-approved and investigational devices and endoscopic bariatric therapies for the treatment of obesity. We focus on literature published in the past few years and present mechanisms of action as well as efficacy and safety data. RECENT FINDINGS: Devices and endoscopic procedures are emerging options to fill the significant treatment gap in the management of obesity. Not only are these devices and procedures minimally invasive and reversible, but they are potentially more effective than antiobesity medications, often safer for poor surgical candidates and possibly less expensive than bariatric surgery...
April 17, 2018: Current Obesity Reports
https://www.readbyqxmd.com/read/29575783/adopt-obesity-treatment-reaches-level-of-maturity-with-its-own-collaborative-initiative-and-resource
#2
EDITORIAL
Wanda Truong, Louis J Aronne
No abstract text is available yet for this article.
April 2018: Obesity
https://www.readbyqxmd.com/read/29425781/single-fluid-filled-intragastric-balloon-safe-and-effective-for-inducing-weight-loss-in-a-real-world-population
#3
Eric J Vargas, Carl M Pesta, Ahmad Bali, Eric Ibegbu, Fateh Bazerbachi, Rachel L Moore, Vivek Kumbhari, Reem Z Sharaiha, Trace W Curry, Gina DosSantos, Ramsey Schmitz, Abhishek Agnihotri, Aleksey A Novikov, Tracy Pitt, Margo K Dunlap, Andrea Herr, Louis Aronne, Erin Ledonne, Hoda C Kadouh, Lawrence J Cheskin, Manpreet S Mundi, Andres Acosta, Christopher J Gostout, Barham K Abu Dayyeh
BACKGROUND & AIMS: The Orbera intragastric balloon (OIB) is a single fluid-filled intragastric balloon approved for induction of weight loss and treatment of obesity. However, little is known about the effectiveness and safety of outside clinical trials, and since approval, the Food and Drug Administration has issued warnings to health care providers about risk of balloon hyperinflation requiring early removal, pancreatitis, and death. We analyzed data on patients who have received the OIB since its approval to determine its safety, effectiveness, and tolerance in real-world clinical settings...
February 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29415209/xylogenesis-reveals-the-genesis-and-ecological-signal-of-iadfs-in-pinus-pinea-l-and-arbutus-unedo-l
#4
A Balzano, K Cufar, G Battipaglia, M Merela, P Prislan, G Aronne, V De Micco
Background and Aims: Mediterranean trees have patterns of cambial activity with one or more pauses per year, leading to intra-annual density fluctuations (IADFs) in tree rings. We analysed xylogenesis (January 2015-January 2016) in Pinus pinea L. and Arbutus unedo L., co-occurring at a site on Mt. Vesuvius (southern Italy), to identify the cambial productivity and timing of IADF formation. Methods: Dendrochronological methods and quantitative wood anatomy were applied and enabled IADF identification and classification...
February 3, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29376439/pharmacotherapy-for-obesity-in-individuals-with-type-2-diabetes
#5
REVIEW
Tariq Chukir, Alpana P Shukla, Katherine H Saunders, Louis J Aronne
Type 2 diabetes (T2DM) is associated with significant morbidity and mortality. Obesity is one of the main risk factors for T2DM and its management requires a multidisciplinary approach, which may include pharmacotherapy. Areas covered: In this paper, data on efficacy, tolerability and safety of FDA-approved pharmacotherapies for obesity (orlistat, phentermine/topiramate extended-release, lorcaserin, bupropion sustained release/naltrexone sustained release and liraglutide) are reviewed, focusing on individuals with type 2 diabetes...
February 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29363287/effect-of-lorcaserin-alone-and-in-combination-with-phentermine-on-food-cravings-after-12-week-treatment-a-randomized-substudy
#6
Candida J Rebello, Elena V Nikonova, Sharon Zhou, Louis J Aronne, Ken Fujioka, W Timothy Garvey, Steven R Smith, Ann A Coulter, Frank L Greenway
OBJECTIVE: This study evaluated the effect of lorcaserin 10 mg twice daily (LOR BID), or with phentermine 15 mg once daily (LOR BID + PHEN QD) and 15 mg twice daily (LOR BID + PHEN BID), in conjunction with energy restriction on food cravings. METHODS: Two hundred and thirty-five patients without diabetes but with obesity or overweight and ≥ 1 comorbidity received LOR BID, LOR BID + PHEN QD, or LOR BID + PHEN BID for 12 weeks in a randomized double-blind study...
February 2018: Obesity
https://www.readbyqxmd.com/read/29206163/frozen-microemulsions-for-maple-immobilization-of-lipase
#7
Valeria Califano, Francesco Bloisi, Giuseppe Perretta, Antonio Aronne, Giovanni Ausanio, Aniello Costantini, Luciano Vicari
Candida rugosa lipase (CRL) was deposited by matrix assisted pulsed laser evaporation (MAPLE) in order to immobilize the enzyme with a preserved native conformation, which ensures its catalytic functionality. For this purpose, the composition of the MAPLE target was optimized by adding the oil phase pentane to a water solution of the amino acid 3-(3,4-dihydroxyphenyl)-2-methyl-l-alanine (m-DOPA), giving a target formed by a frozen water-lipase-pentane microemulsion. Fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) were used to investigate the structure of MAPLE deposited lipase films...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29156182/obesity-pharmacotherapy
#8
REVIEW
Katherine H Saunders, Devika Umashanker, Leon I Igel, Rekha B Kumar, Louis J Aronne
Although diet, physical activity, and behavioral modifications are the cornerstones of weight management, weight loss achieved by lifestyle modifications alone is often limited and difficult to maintain. Pharmacotherapy for obesity can be considered if patients have a body mass index (BMI) of 30 kg/m2 or greater or BMI of 27 kg/m2 or greater with weight-related comorbidities. The 6 most commonly used antiobesity medications are phentermine, orlistat, phentermine/topiramate extended release, lorcaserin, naltrexone sustained release (SR)/bupropion SR, and liraglutide 3...
January 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29110192/endoscopic-sleeve-gastroplasty-laparoscopic-sleeve-gastrectomy-and-laparoscopic-band-for-weight-loss-how-do-they-compare
#9
Aleksey A Novikov, Cheguevara Afaneh, Monica Saumoy, Viviana Parra, Alpana Shukla, Gregory F Dakin, Alfons Pomp, Enad Dawod, Shawn Shah, Louis J Aronne, Reem Z Sharaiha
BACKGROUND: Endoscopic sleeve gastroplasty (ESG) is a novel endobariatric procedure. Initial studies demonstrated an association of ESG with weight loss and improvement of obesity-related comorbidities. Our aim was to compare ESG to laparoscopic sleeve gastrectomy (LSG) and laparoscopic adjustable gastric banding (LAGB). METHODS: We included 278 obese (BMI > 30) patients who underwent ESG (n = 91), LSG (n = 120), or LAGB (n = 67) at our tertiary care academic center...
February 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28991935/obesity-when-to-consider-medication
#10
REVIEW
Katherine H Saunders, Alpana P Shukla, Leon I Igel, Louis J Aronne
These 4 cases illustrate how weight loss drugs--including the 4 newest--can be integrated into a treatment plan that includes diet, exercise, and behavior modification.
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28989726/carbohydrate-last-meal-pattern-lowers-postprandial-glucose-and-insulin-excursions-in-type-2-diabetes
#11
Alpana P Shukla, Jeselin Andono, Samir H Touhamy, Anthony Casper, Radu G Iliescu, Elizabeth Mauer, Yuan Shan Zhu, David S Ludwig, Louis J Aronne
BACKGROUND: There are limited data regarding the timing of carbohydrate ingestion during a meal and postprandial glucose regulation. METHODS: Sixteen subjects with type 2 diabetes mellitus (T2DM) consumed the same meal on 3 days in random order: carbohydrate first, followed 10 min later by protein and vegetables; protein and vegetables first, followed 10 min later by carbohydrate; or all components together. Blood was sampled for glucose, insulin, glucagon-like peptide-1 (GLP-1), and glucagon measurements at baseline (just before meal ingestion) and subsequently at 30 min intervals up to 180 min...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28950422/liraglutide-and-cardiovascular-outcomes-in-adults-with-overweight-or-obesity-a-post-hoc-analysis-from-scale-randomized-controlled-trials
#12
M J Davies, L J Aronne, I D Caterson, A B Thomsen, P B Jacobsen, S P Marso
The cardiovascular safety of liraglutide, a glucagon-like peptide-1 receptor agonist approved for weight management at a dose of 3.0 mg, was evaluated post hoc using data from 5908 participants in 5 randomized, double-blind, placebo-controlled clinical trials. Participants were randomized to liraglutide or a comparator group (placebo or orlistat). The objective was to evaluate whether cardiovascular risk was increased with liraglutide treatment. The primary composite outcome of this time-to-event analysis was the first occurrence of cardiovascular death, nonfatal myocardial infarction or nonfatal stroke...
March 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28843586/a-single-operator-learning-curve-analysis-for-the-endoscopic-sleeve-gastroplasty
#13
Monica Saumoy, Yecheskel Schneider, Xi Kathy Zhou, Alpana Shukla, Michel Kahaleh, Louis Aronne, Reem Z Sharaiha
BACKGROUND AND AIMS: Endoscopic sleeve gastroplasty (ESG) is a novel, incisionless technique for gastric volume reduction to promote weight loss. Our aim was to describe the learning curve for performing ESG using a prospective case series. METHODS: Using a prospective case series design, we analyzed the first 128 consecutive patients at a tertiary care academic medical center who underwent ESG performed by a single operator from August 2013 to December 2016. Efficiency (refining performance to decrease procedure time) and mastery (absence of outliers) for performing ESG was evaluated by using a penalized basis-spline regression and cumulative sum analysis...
February 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28789868/space-time-mesh-adaptation-for-solute-transport-in-randomly-heterogeneous-porous-media
#14
Aronne Dell'Oca, Giovanni Michele Porta, Alberto Guadagnini, Monica Riva
We assess the impact of an anisotropic space and time grid adaptation technique on our ability to solve numerically solute transport in heterogeneous porous media. Heterogeneity is characterized in terms of the spatial distribution of hydraulic conductivity, whose natural logarithm, Y, is treated as a second-order stationary random process. We consider nonreactive transport of dissolved chemicals to be governed by an Advection Dispersion Equation at the continuum scale. The flow field, which provides the advective component of transport, is obtained through the numerical solution of Darcy's law...
July 5, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28660593/is-obesity-the-new-hypertension-parallels-in-the-evolution-of-obesity-and-hypertension-as-recognized-disease-states
#15
REVIEW
Devika Umashanker, Alpana P Shukla, Katherine H Saunders, Louis J Aronne
Obesity and hypertension are recognized disease states that share many similarities including complex physiology, therapeutic response to both lifestyle modification and pharmacotherapy, and the need for long-term management. Both were initially believed to be disorders of lifestyle rather than true disease entities, and initial efforts at developing medical and surgical therapies were criticized. Ultimately, both have proven to be amenable to treatments that control their underlying physiology. Both hypertension and obesity have complex pathophysiology involving multiple regulatory pathways that may require combination therapies in addition to lifestyle modification to reach therapeutic goals...
August 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28544791/the-american-board-of-obesity-medicine-five-year-report
#16
Robert F Kushner, Dana Brittan, John Cleek, Dyan Hes, Wayne English, Scott Kahan, Louis J Aronne
No abstract text is available yet for this article.
June 2017: Obesity
https://www.readbyqxmd.com/read/28529515/changes-in-leaf-anatomical-traits-enhanced-photosynthetic-activity-of-soybean-grown-in-hydroponics-with-plant-growth-promoting-microorganisms
#17
Roberta Paradiso, Carmen Arena, Veronica De Micco, Maria Giordano, Giovanna Aronne, Stefania De Pascale
The use of hydroponic systems for cultivation in controlled climatic conditions and the selection of suitable genotypes for the specific environment help improving crop growth and yield. We hypothesized that plant performance in hydroponics could be further maximized by exploiting the action of plant growth-promoting organisms (PGPMs). However, the effects of PGPMs on plant physiology have been scarcely investigated in hydroponics. Within a series of experiments aimed to identify the best protocol for hydroponic cultivation of soybean [Glycine max (L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28451929/endoscopic-sleeve-gastroplasty-for-obesity-a-multicenter-study-of-248-patients-with-24-months-follow-up
#18
MULTICENTER STUDY
Gontrand Lopez-Nava, Reem Z Sharaiha, Eric J Vargas, Fateh Bazerbachi, Galvao Neto Manoel, Inmaculada Bautista-Castaño, Andres Acosta, Mark D Topazian, Manpreet S Mundi, Nikhil Kumta, Michel Kahaleh, Andrea Marie Herr, Alpana Shukla, Louis Aronne, Christopher J Gostout, Barham K Abu Dayyeh
BACKGROUND: Endoscopic sleeve gastroplasty (ESG) is a technique for managing mild to moderately obese patients. We aimed to evaluate the long-term outcomes, reproducibility, and predictors of weight response in a large multicenter cohort. METHODS: Patients who underwent ESG between January 2013 and December 2015 in three centers were retrospectively analyzed. All procedures were performed using the Apollo OverStitch device (Apollo Endosurgery, Austin, TX). We performed per protocol (PP) and intention-to-treat (ITT) analyses, where patients lost to follow-up were considered failures...
October 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28440045/coadministration-of-lorcaserin-and-phentermine-for-weight-management-a-12-week-randomized-pilot-safety-study
#19
RANDOMIZED CONTROLLED TRIAL
Steven R Smith, W Timothy Garvey, Frank L Greenway, Sharon Zhou, Randi Fain, Robert Pilson, Ken Fujioka, Louis J Aronne
OBJECTIVE: To assess the short-term tolerability of lorcaserin alone or with two dose regimens of phentermine. METHODS: This was a 12-week, randomized, double-blind, pilot safety study of N = 238 nondiabetic patients with obesity or overweight with ≥1 comorbidity randomized to lorcaserin 10 mg twice daily (BID; LOR BID) alone or with phentermine 15 mg once daily (QD; LOR BID+PHEN QD) or 15 mg twice daily (LOR BID+PHEN BID). Patients reporting ≥ 1 of 9 potentially serotonergic adverse events (AEs), mean weight loss (WL), and ≥5% WL are reported...
May 2017: Obesity
https://www.readbyqxmd.com/read/28371396/use-of-lorcaserin-for-glycemic-control-in-patients-with-type-2-diabetes-mellitus
#20
Leon I Igel, Louis J Aronne
No abstract text is available yet for this article.
May 2017: Obesity
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