keyword
MENU ▼
Read by QxMD icon Read
search

Arrone

keyword
https://www.readbyqxmd.com/read/29301585/a-randomised-pragmatic-trial-of-corticosteroid-optimization-in-severe-asthma-using-a-composite-biomarker-algorithm-to-adjust-corticosteroid-dose-versus-standard-care-study-protocol-for-a-randomised-trial
#1
Catherine E Hanratty, John G Matthews, Joseph R Arron, David F Choy, Ian D Pavord, P Bradding, Christopher E Brightling, Rekha Chaudhuri, Douglas C Cowan, Ratko Djukanovic, Nicola Gallagher, Stephen J Fowler, Tim C Hardman, Tim Harrison, Cécile T Holweg, Peter H Howarth, James Lordan, Adel H Mansur, Andrew Menzies-Gow, Sofia Mosesova, Robert M Niven, Douglas S Robinson, Dominick E Shaw, Samantha Walker, Ashley Woodcock, Liam G Heaney
BACKGROUND: Patients with difficult-to-control asthma consume 50-60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all patients with asthma have a typical type 2 (T2)-driven eosinophilic inflammation. These asthmatics have been called 'T2-low asthma' and have a minimal response to corticosteroid therapy. Adjustment of corticosteroid treatment using sputum eosinophil counts from induced sputum has demonstrated reduced severe exacerbation rates and optimized corticosteroid dose...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29199786/analysis-of-the-acceleration-profile-according-to-initial-speed-and-positional-role-in-elite-professional-male-soccer-players
#2
Moisés de Hoyo, Borja Sañudo, Luis Suárez-Arrones, Luis Carrasco, Tom Joel, Sergio Domínguez-Cobo, Francisco J Núñez
BACKGROUND: The aim of the current study was to analyse the acceleration profile in elite professional soccer players according to their initial speed but also considering players' position. METHODS: Players' accelerations profiles were analysed using a relative acceleration profile according to the initial speed (S1, from 0 to 7 km/h; S2, from 7.1 to 14.3 km/h; and S3, ≥14.4 km/h) and the maximum acceleration. RESULTS: Within-group analyses showed that Center Backs (CB) performed more high intensity accelerations (likely) when they started in S1 than S2 (ES: 0...
December 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29198781/effectiveness-of-low-level-laser-therapy-in-lichen-planopilaris
#3
Pablo Fonda-Pascual, Oscar M Moreno-Arrones, David Saceda-Corralo, Ana R Rodrigues-Barata, Cristina Pindado-Ortega, Pablo Boixeda, Sergio Vaño-Galvan
No abstract text is available yet for this article.
November 30, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29192981/organ-transplantation-and-cutaneous-squamous-cell-carcinoma-progress-pitfalls-and-priorities-in-immunosuppression-associated-keratinocyte-carcinoma
#4
EDITORIAL
C A Harwood, S T Arron, C M Proby, M M Asgari, J N Bouwes Bavinck, A C Green, A E Toland
No abstract text is available yet for this article.
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29182455/isolation-of-blood-brain-barrier-crossing-antibodies-from-a-phage-display-library-by-competitive-elution-and-their-ability-to-penetrate-the-central-nervous-system
#5
George Thom, Jon Hatcher, Arron Hearn, Judy Paterson, Natalia Rodrigo, Arthur Beljeana Ian Gurrell, Carl Webster
The blood-brain barrier (BBB) is a formidable obstacle for delivery of biologic therapeutics to central nervous system (CNS) targets. Whilst the BBB prevents passage of the vast majority of molecules, it also selectively transports a wide variety of molecules required to maintain brain homeostasis. Receptor-mediated transcytosis is one example of a macromolecule transport system that is employed by cells of the BBB to supply essential proteins to the brain and which can be utilized to deliver biologic payloads, such as antibodies, across the BBB...
November 28, 2017: MAbs
https://www.readbyqxmd.com/read/29162521/intrinsic-insula-network-engagement-underlying-children-s-reading-and-arithmetic-skills
#6
Ting-Ting Chang, Pei-Hong Lee, Arron W S Metcalfe
The neural substrates of children's reading and arithmetic skills have long been of great interest to cognitive neuroscientists. However, most previous studies have focused on the contrast between these skills as specific domains. Here, we investigate the potentially shared processes across these domains by focusing on how the neural circuits associated with cognitive control influence reading and arithmetic proficiency in 8-to-10-year-old children. Using a task-free resting state approach, we correlated the intrinsic functional connectivity of the right anterior insula (rAI) network with performance on assessments of Chinese character recognition, reading comprehension, subtraction, and multiplication performance...
November 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29141020/genomic-analysis-of-atypical-fibroxanthoma
#7
Kevin Lai, Catherine A Harwood, Karin J Purdie, Charlotte M Proby, Irene M Leigh, Namita Ravi, Thaddeus W Mully, Lionel Brooks, Priscilla M Sandoval, Michael D Rosenblum, Sarah T Arron
Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA sequencing of 8 matched tumor-normal samples. AFX is a highly mutated malignancy with recurrent mutations in a number of genes, including COL11A1, ERBB4, CSMD3, and FAT1. The majority of mutations identified were UV signature (C>T in dipyrimidines). We observed deletion of chromosomal segments on chr9p and chr13q, including tumor suppressor genes such as KANK1 and CDKN2A, but no gene fusions were found...
2017: PloS One
https://www.readbyqxmd.com/read/29110877/impact-on-quality-of-life-in-dermatology-patients-attending-an-emergency-department
#8
A Alegre-Sánchez, D de Perosanz-Lobo, A Pascual-Sánchez, C Pindado-Ortega, P Fonda-Pascual, Ó M Moreno-Arrones, P Jaén-Olasolo
INTRODUCTION: Dermatological complaints have been estimated to represent up to 5-10% of all the visits to emergency departments. The main objective of our study was to determine how affected is the Health related Quality of Life (HRQL) in a series of patients attending an emergency department due to skin symptoms. PATIENTS AND METHODS: A prospective study during one month (July 2016) was conducted in a hospital with full-time on-call dermatologists. The Short-Form SF-12v2 Health Survey and the Dermatology Life Quality Index (DLQI) were offered to all the patients over 18 years old attending the emergency department with cutaneous complaints...
October 28, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29077553/greater-body-mass-index-is-associated-with-reduced-frontal-cortical-volumes-among-adolescents-with-bipolar-disorder
#9
Alvi H Islam, Arron W S Metcalfe, Bradley J MacIntosh, Daphne J Korczak, Benjamin I Goldstein
BACKGROUND: Higher body mass index (BMI) and obesity is common among youth with bipolar disorder (BD) and is associated with greater psychiatric illness severity, including suicidality. Obesity has been associated with frontal, temporal and subcortical volumetric reductions in adults with BD. We examined the neurostructural correlates of BMI in adolescents early in their course of BD. METHODS: We processed T1-weighted images of adolescents with BD and psychiatrically healthy controls using FreeSurfer to derive a priori region of interest (ROI) volumes/cortical thickness for the frontal lobe (FL), prefrontal cortex (PFC) and orbitofrontal cortex (OFC) as well as volumes for the amygdala and hippocampus...
October 27, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29064281/interferon-stimulated-gene-expression-type-2-inflammation-and-endoplasmic-reticulum-stress-in-asthma
#10
Nirav R Bhakta, Stephanie A Christenson, Srilaxmi Nerella, Owen D Solberg, Christine P Nguyen, David F Choy, Kyle L Jung, Suresh Garudadri, Luke R Bonser, Joshua L Pollack, Lorna T Zlock, David J Erle, Charles Langelier, Joseph L Derisi, Joseph R Arron, John V Fahy, Prescott G Woodruff
RATIONALE: Quantification of type-2 inflammation provided a molecular basis for heterogeneity in asthma. Non-type-2 pathways that contribute to asthma pathogenesis are not well understood. OBJECTIVES: To identify dysregulated pathways beyond type-2 inflammation. METHODS: We applied RNA sequencing to airway epithelial brushings obtained from stable mild asthmatics not on corticosteroids (n=19) and healthy controls (n=16). Sequencing reads were mapped to human and viral genomes...
October 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29059611/validating-epilepsy-diagnoses-in-routinely-collected-data
#11
Beata Fonferko-Shadrach, Arron S Lacey, Catharine P White, H W Rob Powell, Inder M S Sawhney, Ronan A Lyons, Phil E M Smith, Mike P Kerr, Mark I Rees, W Owen Pickrell
PURPOSE: Anonymised, routinely-collected healthcare data is increasingly being used for epilepsy research. We validated algorithms using general practitioner (GP) primary healthcare records to identify people with epilepsy from anonymised healthcare data within the Secure Anonymised Information Linkage (SAIL) databank in Wales, UK. METHOD: A reference population of 150 people with definite epilepsy and 150 people without epilepsy was ascertained from hospital records and linked to records contained within SAIL (containing GP records for 2...
October 13, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29034234/interleukin-13-in-asthma-and-other-eosinophilic-disorders
#12
Emma Doran, Fang Cai, Cécile T J Holweg, Kit Wong, Jochen Brumm, Joseph R Arron
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity, asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. While it is appreciated that eosinophilia is present in only a subset of patients, it remains a key feature of asthma and other eosinophilic disorders such as atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis with nasal polyps...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29031659/validity-of-skin-cancer-malignancy-reporting-to-the-organ-procurement-transplant-network-a-cohort-study
#13
Giorgia L Garrett, Joyce T Yuan, Thuzar M Shin, Sarah T Arron
BACKGROUND: The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. OBJECTIVE: The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. METHODS: This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database...
October 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29029907/acne-sexual-orientation-and-mental-health-among-young-adults-in-the-united-states-a-population-based-cross-sectional-study
#14
Yi Gao, Esther K Wei, Sarah T Arron, Eleni Linos, David J Margolis, Matthew D Mansh
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28974641/adenohypophysis-placodal-precursors-exhibit-distinctive-features-within-the-rostral-preplacodal-ectoderm
#15
Luisa Sanchez-Arrones, África Sandonís, Marcos Julián Cardozo, Paola Bovolenta
Placodes are discrete thickenings of the vertebrate cranial ectoderm that generate morpho-functionally distinct structures, such as the adenohypophysis, olfactory epithelium and lens. All placodes arise from a horseshoe-shaped preplacodal ectoderm in which the precursors of individual placodes are intermingled. However, fate-map studies indicated that cells positioned at the preplacodal midline give rise to only the adenohypophyseal placode, suggesting a unique organization of these precursors within the preplacode...
October 1, 2017: Development
https://www.readbyqxmd.com/read/28960458/videodermoscopy-and-doppler-ultrasound-in-spider-naevi-towards-a-new-classification
#16
Adrian Alegre-Sanchez, Claudia Bernárdez, Pablo Fonda-Pascual, Óscar M Moreno-Arrones, Juan Carlos López-Gutiérrez, Pedro Jaen-Olasolo, Pablo Boixeda
INTRODUCTION: spider naevi (SN) are considered a subtype of telangiectasias, currently classified as low-flow vascular malformations. OBJECTIVE: to describe the videodermoscopy and doppler-ultrasound (US) features of a large group of SN. MATERIAL AND METHODS: a retrospective study of cases of SN collected at our Dermatology department during the period between June 2015- June 2017 was performed. Clinical, dermoscopic, videodermoscopic and Doppler-US were reviewed...
September 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28952162/risk-prediction-tools-for-keratinocyte-carcinoma-after-solid-organ-transplantation-a-review-of-the-literature
#17
REVIEW
S E Lowenstein, G Garrett, A E Toland, A Jambusaria-Pahlajani, M M Asgari, A Green, E A Engels, S T Arron
Long-term iatrogenic immunosuppression increases the risk of cutaneous malignancies in organ transplant recipients (OTRs), particularly the keratinocyte cancers basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC). cSCC is the most common malignancy in OTRs, with the risk increased to over 65-fold in transplanted patients relative to the general population. There have been very few risk prediction tools developed for accurate determination of the risk of developing keratinocyte cancers in the OTR population...
September 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28948856/preliminary-dual-center-experience-with-the-bolton-treovance-endograft
#18
MULTICENTER STUDY
Arron Thind, Dhruv Sarma, Abdel Kader Allouni, Feras Abdallah, David Murray, Kiran Thind, Chris Darby, Ashok Handa, Ed Sideso, Rafiuddin Patel, Mark Bratby, Raman Uberoi
PURPOSE: To present the performance and safety of the Treovance stent graft for endovascular aortic aneurysm repair in a "real-world" patient cohort. METHODS: Patients from 2 centers, deemed unfit for open repair, were electively treated with the Treovance endograft. Clinical preoperative, operative, and up to 1-year postoperative follow-up data of patients were retrospectively analyzed. RESULTS: This study included 46 patients with abdominal aortic aneurysm (44 male), mean age of 78 years ± 8 standard deviation (SD; range: 58-93 years)...
November 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28947289/development-and-validation-of-the-frontal-fibrosing-alopecia-severity-score
#19
D Saceda-Corralo, O M Moreno-Arrones, P Fonda-Pascual, C Pindado-Ortega, D Buendía-Castaño, A Alegre-Sánchez, G Segurado-Miravalles, A R Rodrigues-Barata, P Jaén-Olasolo, S Vaño-Galván
No abstract text is available yet for this article.
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28944642/variability-of-gps-derived-running-performance-during-official-matches-in-elite-professional-soccer-players
#20
Hani Al Haddad, Alberto Méndez-Villanueva, Nacho Torreño, Diego Munguía-Izquierdo, Luis Suárez-Arrones
AIM: The aim of this study was to assess the match-to-match variability obtained using GPS devices, collected during official games in professional soccer players. METHODS: GPS-derived data from nineteen elite soccer players were collected over two consecutive seasons. Time-motion data for players with more than five full-match were analyzed (n=202). Total distance covered (TD), TD >13-18 km/h, TD >18-21 km/h, TD >21 km/h, number of acceleration >2.5-4 m...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
keyword
keyword
56224
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"