keyword
MENU ▼
Read by QxMD icon Read
search

Arrone

keyword
https://www.readbyqxmd.com/read/27846956/trichoscopy-of-dissecting-cellulitis-of-the-scalp-exclamation-mark-hairs-and-white-dots-as-markers-of-disease-chronicity
#1
Gonzalo Segurado-Miravalles, Francisco Camacho-Martınez, Salvador Arias-Santiago, Rita Rodrigues-Barata, Cristina Serrano-Falcón, Oscar Muñoz Moreno-Arrones, Pedro Jaén Olasolo, Sergio Vañó-Galván
No abstract text is available yet for this article.
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27822553/mockrobiota-a-public-resource-for-microbiome-bioinformatics-benchmarking
#2
Nicholas A Bokulich, Jai Ram Rideout, William G Mercurio, Arron Shiffer, Benjamin Wolfe, Corinne F Maurice, Rachel J Dutton, Peter J Turnbaugh, Rob Knight, J Gregory Caporaso
Mock communities are an important tool for validating, optimizing, and comparing bioinformatics methods for microbial community analysis. We present mockrobiota, a public resource for sharing, validating, and documenting mock community data resources, available at http://caporaso-lab.github.io/mockrobiota/. The materials contained in mockrobiota include data set and sample metadata, expected composition data (taxonomy or gene annotations or reference sequences for mock community members), and links to raw data (e...
September 2016: MSystems
https://www.readbyqxmd.com/read/27793094/network-analysis-of-psoriasis-reveals-biological-pathways-and-roles-for-coding-and-long-non-coding-rnas
#3
Richard Ahn, Rashmi Gupta, Kevin Lai, Nitin Chopra, Sarah T Arron, Wilson Liao
BACKGROUND: Psoriasis is an immune-mediated, inflammatory disorder of the skin characterized by chronic inflammation and hyperproliferation of the epidermis. Differential expression analysis of microarray or RNA-seq data have shown that thousands of coding and non-coding genes are differentially expressed between psoriatic and healthy control skin. However, differential expression analysis may fail to detect perturbations in gene coexpression networks. Sensitive detection of such networks may provide additional insight into important disease-associated pathways...
October 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27792964/increased-cerebral-blood-flow-among-adolescents-with-bipolar-disorder-at-rest-is-reduced-following-acute-aerobic-exercise
#4
Bradley J MacIntosh, Zahra Shirzadi, Antonette Scavone, Arron Ws Metcalfe, Alvi H Islam, Daphne Korczak, Benjamin I Goldstein
OBJECTIVE: Cerebral blood flow (CBF) is altered in mood disorders but has not been examined among adolescents with bipolar disorder (BD). Similarly, little is known about the acute neurophysiologic effects of aerobic exercise in BD. We therefore compared CBF between adolescents with and without BD at rest and acutely following a single exercise session. METHODS: Thirty-one adolescents with BD and 20 age and sex-matched controls participated in this study. CBF magnetic resonance images (MRI) were acquired using arterial spin labeling at a baseline as well as 15 and 45min after a single 20-min session of recumbent cycling...
October 21, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27774711/versatile-catalytic-hydrogenation-using-a-simple-tin-iv-lewis-acid
#5
Daniel J Scott, Nicholas A Phillips, Joshua S Sapsford, Arron C Deacy, Matthew J Fuchter, Andrew E Ashley
Despite the rapid development of frustrated Lewis pair (FLP) chemistry over the last ten years, its application in catalytic hydrogenations remains dependent on a narrow family of structurally similar early main-group Lewis acids (LAs), inevitably placing limitations on reactivity, sensitivity and substrate scope. Herein we describe the FLP-mediated H2 activation and catalytic hydrogenation activity of the alternative LA iPr3 SnOTf, which acts as a surrogate for the trialkylstannylium ion iPr3 Sn(+) , and is rapidly and easily prepared from simple, inexpensive starting materials...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27764798/safety-and-efficacy-of-vismodegib-in-patients-aged-%C3%A2-65-years-with-advanced-basal-cell-carcinoma
#6
Anne Lynn S Chang, Karl D Lewis, Sarah T Arron, Michael R Migden, James A Solomon, Simon Yoo, Bann-Mo Day, Edward F McKenna, Aleksandar Sekulic
Because many patients with unresectable basal cell carcinoma (BCC) are aged ≥65 years, this study explores the efficacy and safety of vismodegib in these patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC) in the ERIVANCE BCC trial and the expanded access study (EAS).We compared patients aged ≥65 years to patients aged <65 years taking vismodegib 150 mg/day, using descriptive statistics for response and safety. Patients aged ≥65 years (laBCC/mBCC) were enrolled in ERIVANCE BCC (33/14) and EAS (27/26)...
October 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27712082/fit-for-purpose-biomarker-immunoassay-qualification-and-validation-three-case-studies
#7
Kyra Cowan, Xiaoying Gao, Vaishali Parab, Trung Nguy, Lawren Wu, Joseph R Arron, Michael Townsend, Jeffrey Wallin, Melissa Cheu, Alyssa Morimoto, Eric Wakshull
AIM: To improve on the efficiency of biomarker assay readiness, and for reliable biomarker data to support three drug programs, we implemented a fit-for-purpose approach, qualifying two biomarker assays and validating a third. Results/methodology: The qualification strategy and selection of experiments for two exploratory biomarkers (CXCL1, CCL19) was determined by the intended use of the biomarker data. The third biomarker, IL-6, was validated as the data would be used in monitoring patient safety during dose-escalation studies in a Phase I trial...
October 7, 2016: Bioanalysis
https://www.readbyqxmd.com/read/27705034/the-high-pull-exercise-a-comparison-between-a-versapulley-flywheel-device-and-the-free-weight
#8
F Javier Núñez, Luis J Suarez-Arrones, Paul Cater, Alberto Mendez-Villanueva
The aim of this study was to examine the kinematics and kinetics (force, velocity and acceleration) and blood lactate concentration of the Versapulley (VP) device in comparison with free weight (FW) exercise at a similar external load. Fifteen rugby players randomly performed two training sessions of 6 sets of 6 repetitions with 20 s of recovery in between sets of the high pull exercise with the VP and the FW. Both training sessions were separated by 72 h. Barbell displacement (cm.), peak velocity (m/s), peak acceleration (m/s(2)), mean propulsive velocity (m/s), mean propulsive acceleration (m/s(2)), propulsive phase (%), mean and maximal force (Newtons) were continuously recorded during each repetition...
September 6, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27699264/depletion-of-major-pathogenic-cells-in-asthma-by-targeting-crth2
#9
Tao Huang, Meredith Hazen, Yonglei Shang, Meijuan Zhou, Xiumin Wu, Donghong Yan, Zhonghua Lin, Margaret Solon, Elizabeth Luis, Hai Ngu, Yongchang Shi, Arna Katewa, David F Choy, Nandhini Ramamoorthi, Erick R Castellanos, Mercedesz Balazs, Min Xu, Wyne P Lee, Marissa L Matsumoto, Jian Payandeh, Joseph R Arron, Jo-Anne Hongo, Jianyong Wang, Isidro Hötzel, Cary D Austin, Karin Reif
Eosinophilic inflammation and Th2 cytokine production are central to the pathogenesis of asthma. Agents that target either eosinophils or single Th2 cytokines have shown benefits in subsets of biomarker-positive patients. More broadly effective treatment or disease-modifying effects may be achieved by eliminating more than one inflammatory stimulator. Here we present a strategy to concomitantly deplete Th2 T cells, eosinophils, basophils, and type-2 innate lymphoid cells (ILC2s) by generating monoclonal antibodies with enhanced effector function (19A2) that target CRTh2 present on all 4 cell types...
May 19, 2016: JCI Insight
https://www.readbyqxmd.com/read/27640185/targeted-next-generation-sequencing-of-tp53-in-oral-tongue-carcinoma-from-non-smokers
#10
Daniel L Faden, Sarah T Arron, Chase M Heaton, Joseph DeRisi, Andrew P South, Steven J Wang
BACKGROUND: Little is known regarding the etiology and genomic underpinnings of Oral Tongue Squamous Cell Carcinoma (OTSCC) in patients who lack traditional risk factors, yet the incidence is increasing. In particular, the rate, and role, of TP53 mutations in this cohort has been heavily debated in the literature. METHODS: Tumor DNA from forty-three non-smokers with OTSCC underwent next generation sequencing of TP53. RESULTS: Sixty percent of samples contained a TP53 mutation...
2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27618386/effects-of-velocity-loss-during-resistance-training-on-performance-in-professional-soccer-players
#11
Fernando Pareja-Blanco, Luis Sánchez-Medina, Luis Suárez-Arrones, Juan José González-Badillo
AIM: To analyze the effects of two resistance training (RT) programs that used the same relative loading but different repetition volume, using the velocity loss during the set as the independent variable: 15% (VL15) vs. 30% (VL30). METHODS: Sixteen professional soccer players with RT experience (age 23.8 ± 3.5 years, body mass 75.5 ± 8.6 kg) were randomly assigned to two groups: VL15 (n = 8) or VL30 (n = 8) that followed a 6-week (18 sessions) velocity-based squat training program...
September 6, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27618131/the-high-pull-exercise-a-comparison-between-a-versapulley-flywheel-device-and-the-free-weight
#12
F Javier Núñez, Luis J Suarez-Arrones, Paul Cater, Alberto Mendez-Villanueva
The aim of this study was to examine the kinematics and kinetics (force, velocity and acceleration) and blood lactate concentration of the Versapulley (VP) device in comparison with free weight (FW) exercise at a similar external load. Fifteen rugby players randomly performed two training sessions of 6 sets of 6 repetitions with 20 s of recovery in between sets of the high pull exercise with the VP and the FW. Both training sessions were separated by 72 h. Barbell displacement (cm.), peak velocity (m/s), peak acceleration (m/s2), mean propulsive velocity (m/s), mean propulsive acceleration (m/s2), propulsive phase (%), mean and maximal force (Newtons) were continuously recorded during each repetition...
September 6, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27583444/mri-based-regional-muscle-use-during-hamstring-strengthening-exercises-in-elite-soccer-players
#13
Alberto Mendez-Villanueva, Luis Suarez-Arrones, Gil Rodas, Rodrigo Fernandez-Gonzalo, Per Tesch, Richard Linnehan, Richard Kreider, Valter Di Salvo
The present study examined site-specific hamstring muscles use with functional magnetic resonance imaging (MRI) in elite soccer players during strength training. Thirty-six players were randomized into four groups, each performing either Nordic hamstring, flywheel leg-curl, Russian belt or the hip-extension conic-pulley exercise. The transverse relaxation time (T2) shift from pre- to post-MRI were calculated for the biceps femoris long (BFl) and short (BFs) heads, semitendinosus (ST) and semimembranosus (SM) muscles at proximal, middle and distal areas of the muscle length...
2016: PloS One
https://www.readbyqxmd.com/read/27581207/safety-and-efficacy-of-vismodegib-in-patients-with-basal-cell-carcinoma-nevus-syndrome-pooled-analysis-of-two-trials
#14
Anne Lynn S Chang, Sarah T Arron, Michael R Migden, James A Solomon, Simon Yoo, Bann-Mo Day, Edward F McKenna, Aleksandar Sekulic
BACKGROUND: Aberrant activation of the Hedgehog (Hh) pathway is a key driver in the pathogenesis of basal cell carcinomas (BCCs), including patients with BCC nevus syndrome (BCCNS). It is unclear whether BCCs arising in patients with BCCNS respond differently to vismodegib than in patients without BCCNS. We examined the best overall response rate (BORR) and adverse events (AEs) of vismodegib in patients with advanced BCC (aBCC) with and without BCCNS. METHODS: Patients were treated with vismodegib 150 mg/day in the ERIVANCE BCC trial (ClinicalTrials...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27578884/a-deimmunised-form-of-the-ribotoxin-%C3%AE-sarcin-lacking-cd4-t-cell-epitopes-and-its-use-as-an-immunotoxin-warhead
#15
Tim D Jones, Arron R Hearn, Robert G E Holgate, Dorota Kozub, Mark H Fogg, Francis J Carr, Matthew P Baker, Javier Lacadena, Kurt R Gehlsen
Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phosphodiester bond in the sarcin-ricin loop of the large ribosomal subunit, thus making the ribosome unrecognisable to elongation factors and leading to inhibition of protein synthesis. Peptide mapping using an ex vivo human T cell assay determined that α-sarcin contained two T cell epitopes; one in the N-terminal 20 amino acids and the other in the C-terminal 20 amino acids...
August 29, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27571244/relationship-between-internal-load-indicators-and-changes-on-intermittent-performance-after-the-preseason-in-professional-soccer-players
#16
Miguel A Campos-Vazquez, Francisco J Toscano-Bendala, José Carlos Mora-Ferrera, Luis Suarez-Arrones
The aim of this study was to examine the effects of accumulated internal training load during the preseason (4 weeks) on changes in the intermittent performance, in a professional soccer team. Twelve professionals soccer players (Mean±SD age 27.7±4.3 years; height: 177.1±6.2 cm; body mass: 73.1±5.2 kg; % body fat (Faulkner): 10.2±1.2) belonging to a Spanish second division team (2013-2014) participated in this study. The 30-15 intermittent fitness test was performed before and after the preseason, and the speed for the last period completed by each player was recorded (VIFT)...
August 22, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27566401/irf4-polymorphism-is-associated-with-cutaneous-squamous-cell-carcinoma-in-organ-transplant-recipients-a-pigment-independent-phenomenon
#17
Maryam M Asgari, Amanda E Toland, Sarah T Arron
No abstract text is available yet for this article.
August 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27543334/why-cockayne-syndrome-patients-do-not-get-cancer-despite-their-dna-repair-deficiency
#18
Kate S Reid-Bayliss, Sarah T Arron, Lawrence A Loeb, Vladimir Bezrookove, James E Cleaver
Cockayne syndrome (CS) and xeroderma pigmentosum (XP) are human photosensitive diseases with mutations in the nucleotide excision repair (NER) pathway, which repairs DNA damage from UV exposure. CS is mutated in the transcription-coupled repair (TCR) branch of the NER pathway and exhibits developmental and neurological pathologies. The XP-C group of XP patients have mutations in the global genome repair (GGR) branch of the NER pathway and have a very high incidence of UV-induced skin cancer. Cultured cells from both diseases have similar sensitivity to UV-induced cytotoxicity, but CS patients have never been reported to develop cancer, although they often exhibit photosensitivity...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27538000/effect-of-adalimumab-on-gene-expression-profiles-of-psoriatic-skin-and-blood
#19
Maggie Chow, Kevin Lai, Richard Ahn, Rashmi Gupta, Sarah Arron, Wilson Liao
BACKGROUND: Adalimumab is an anti-TNF biologic drug that is efficacious in the treatment of psoriasis. However, the effect of adalimumab on genome-wide gene expression changes in skin and peripheral blood is not well characterized.<BR /> METHODS: Thirty adult subjects with > 10% body surface area of chronic plaque psoriasis were recruited for the study. Lesional skin and peripheral blood mononuclear cell samples prior to and one month following treatment with adalimumab were collected...
August 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27536249/similar-inflammatory-responses-following-sprint-interval-training-performed-in-hypoxia-and-normoxia
#20
Alan J Richardson, Rebecca L Relf, Arron Saunders, Oliver R Gibson
Sprint interval training (SIT) is an efficient intervention capable of improving aerobic capacity and exercise performance. This experiment aimed to determine differences in training adaptations and the inflammatory responses following 2 weeks of SIT (30 s maximal work, 4 min recovery; 4-7 repetitions) performed in normoxia or hypoxia. Forty-two untrained participants [(mean ± SD), age 21 ±1 years, body mass 72.1 ±11.4 kg, and height 173 ±10 cm] were equally and randomly assigned to one of three groups; control (CONT; no training, n = 14), normoxic (NORM; SIT in FiO2: 0...
2016: Frontiers in Physiology
keyword
keyword
56224
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"