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https://www.readbyqxmd.com/read/29767279/identification-and-validation-of-qtl-for-grain-yield-and-plant-water-status-under-contrasting-water-treatments-in-fall-sown-spring-wheats
#1
Junli Zhang, Shiferaw Abate Gizaw, Eligio Bossolini, Joshua Hegarty, Tyson Howell, Arron H Carter, Eduard Akhunov, Jorge Dubcovsky
Chromosome regions affecting grain yield, grain yield components and plant water status were identified and validated in fall-sown spring wheats grown under full and limited irrigation. Increases in wheat production are required to feed a growing human population. To understand the genetic basis of grain yield in fall-sown spring wheats, we performed a genome-wide association study (GWAS) including 262 photoperiod-insensitive spring wheat accessions grown under full and limited irrigation treatments. Analysis of molecular variance showed that 4...
May 16, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29765970/clinical-description-of-frontal-fibrosing-alopecia-with-concomitant-lichen-planopilaris
#2
David Saceda-Corralo, Pablo Fernández-Crehuet, Pablo Fonda-Pascual, Cristina Pindado-Ortega, Oscar M Moreno-Arrones, Sergio Vañó-Galván
No abstract text is available yet for this article.
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29733937/steroid-induced-changes-noted-on-trichoscopy-of-patients-with-frontal-fibrosing-alopecia
#3
D Saceda-Corralo, O M Moreno-Arrones, P Fonda-Pascual, C Pindado-Ortega, A Hermosa-Gelbard, A R Rodrigues-Barata, S Vaño-Galván
No abstract text is available yet for this article.
May 4, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29699919/effect-of-cooling-rate-on-sperm-quality-of-cryopreserved-andalusian-donkey-spermatozoa
#4
S Demyda-Peyrás, M Bottrel, D Acha, I Ortiz, M Hidalgo, J J Carrasco, V Gómez-Arrones, J Gósalvez, J Dorado
The aim of this study was to evaluate the effect of different cooling rates on post-thaw quality of cryopreserved donkey spermatozoa. Eighteen ejaculates from six adult Andalusian donkeys (three ejaculates per donkey) were collected using an artificial vagina. Pooled semen samples (two ejaculates per pool) were divided into three aliquots, and frozen in Gent freezing extender using three different cryopreservation protocols (P): P1 (conventional slow freezing, as control): semen pre-cooled in an Equitainer for 2 h and frozen in liquid nitrogen (LN2 ) vapour; P2 (controlled pre-freeze cooling rate): semen pre-cooled at a controlled rate for 73 min and frozen in LN2 vapour; and P3 (rapid freezing) semen frozen immediately in LN2 vapour...
April 20, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29672914/revisiting-the-nih-taskforce-on-the-research-needs-of-eosinophil-associated-diseases-re-tread
#5
REVIEW
Paneez Khoury, Praveen Akuthota, Steven J Ackerman, Joseph R Arron, Bruce S Bochner, Margaret H Collins, Jean-Emmanuel Kahn, Patricia C Fulkerson, Gerald J Gleich, Rashmi Gopal-Srivastava, Elizabeth A Jacobsen, Kristen M Leiferman, Levi-Schaffer Francesca, Sameer K Mathur, Michael Minnicozzi, Calman Prussin, Marc E Rothenberg, Florence Roufosse, Kathleen Sable, Dagmar Simon, Hans-Uwe Simon, Lisa A Spencer, Jonathan Steinfeld, Andrew J Wardlaw, Michael E Wechsler, Peter F Weller, Amy D Klion
BACKGROUND: Eosinophil-associated diseases (EADs) are rare, heterogeneous disorders characterized by the presence of eosinophils in tissues and/or peripheral blood resulting in immunopathology. The heterogeneity of tissue involvement, lack of sufficient animal models, technical challenges in working with eosinophils, and lack of standardized histopathologic approaches have hampered progress in basic research. Additionally, clinical trials and drug development for rare EADs are limited by the lack of primary and surrogate endpoints, biomarkers, and validated patient-reported outcomes...
April 19, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29656764/prescribing-habits-for-androgenic-alopecia-among-dermatologists-in-spain-in-2017-a-cross-sectional-study
#6
C Pindado-Ortega, D Saceda-Corralo, D Buendía-Castaño, P Fernández-González, Ó M Moreno-Arrones, P Fonda-Pascual, A Alegre-Sánchez, A R Rodrigues-Barata, S Vañó-Galván
BACKGROUND: Topical minoxidil and oral finasteride are the only drugs approved for the treatment of androgenetic alopecia (AGA) in Spain. However, the management of this condition is highly variable because numerous treatments are used off-label. The main aim of this study was to describe the prescribing habits of dermatologists in Spain for male AGA (MAGA) and female AGA (FAGA). MATERIAL AND METHODS: Descriptive cross-sectional study using online questionnaires completed by dermatologists working in Spain...
April 12, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29624485/microbial-glucuronidase-inhibition-reduces-severity-of-diclofenac-induced-anastomotic-leak-in-rats
#7
Simon T K Yauw, Melissa Arron, Roger M L M Lomme, Petra van den Broek, Rick Greupink, Aadra P Bhatt, Matthew R Redinbo, Harry van Goor
BACKGROUND: The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is unclear. Previous data suggest that reactivation of biliary diclofenac metabolites by microbial β-glucuronidases in the gut plays a role in harming the intestinal mucosa, and that microbiome-targeted glucuronidase inhibition prevents this damage. Here, the microbial glucuronidase inhibitor Inh1 was examined for its ability to reduce diclofenac-induced anastomotic leakage in rats...
April 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29608579/genome-wide-association-mapping-for-eyespot-disease-in-us-pacific-northwest-winter-wheat
#8
Megan J Lewien, Timothy D Murray, Kendra L Jernigan, Kimberly A Garland-Campbell, Arron H Carter
Eyespot, caused by the soil-borne necrotrophic fungi Oculimacula yallundae and O. acuformis, is a disease of major economic significance for wheat, barley and rye. Pacific Northwest (PNW) winter wheat (Triticum aestivum L.) grown in areas of high rainfall and moderate winters is most vulnerable to infection. The objective of this research was to identify novel genomic regions associated with eyespot resistance in winter wheat adapted to the PNW. Two winter wheat panels of 469 and 399 lines were compiled for one of the first genome-wide association studies (GWAS) of eyespot resistance in US winter wheat germplasm...
2018: PloS One
https://www.readbyqxmd.com/read/29594737/glomuvenous-malformations-dual-pdl-nd-yag-laser-approach
#9
Oscar Muñoz Moreno-Arrones, Natalia Jimenez, Adrian Alegre-Sanchez, Pablo Fonda, Pablo Boixeda
Glomuvenous malformations are uncommon simple vascular malformations that might be present at birth or appear during childhood that have been classically classified as a subtype of venous malformations. Sclerotherapy and surgery have been used in the past as treatments for this condition although with disappointing results in large glomangiomas. The treatment of these lesions has still not been standardized. We conducted a retrospective study of 17 patients treated with dual wavelength PDL-Nd:YAG. The majority of the patients experience a reduction of at least a 60% in their glomuvenous malformations...
March 29, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29593752/genetic-dissection-of-end-use-quality-traits-in-adapted-soft-white-winter-wheat
#10
Kendra L Jernigan, Jayfred V Godoy, Meng Huang, Yao Zhou, Craig F Morris, Kimberly A Garland-Campbell, Zhiwu Zhang, Arron H Carter
Soft white wheat is used in domestic and foreign markets for various end products requiring specific quality profiles. Phenotyping for end-use quality traits can be costly, time-consuming and destructive in nature, so it is advantageous to use molecular markers to select experimental lines with superior traits. An association mapping panel of 469 soft white winter wheat cultivars and advanced generation breeding lines was developed from regional breeding programs in the U.S. Pacific Northwest. This panel was genotyped on a wheat-specific 90 K iSelect single nucleotide polymorphism (SNP) chip...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29590139/the-effects-of-unilateral-and-bilateral-eccentric-overload-training-on-hypertrophy-muscle-power-and-cod-performance-and-its-determinants-in-team-sport-players
#11
Francisco Javier Núñez, Alfredo Santalla, Irene Carrasquila, Jose Antonio Asian, Jose Ignacio Reina, Luis Jesús Suarez-Arrones
The study aimed to compare the chronic eccentric-overload training effects of unilateral (lateral lunge) vs bilateral (half-squat) using an inertial device, on hypertrophy and physical performance. Twenty-seven young team sports male players performed a 4 sets of 7 repetitions of inertial eccentric overload training, biweekly for 6 weeks, distributed in unilateral lunge group (UG: age: 22.8 ± 2.9 years; body mass: 75.3 ± 8.8 kg; height: 177.3 ± 3.7 cm) and bilateral squat group (BG: age: 22.6 ± 2.7 years; body mass: 79...
2018: PloS One
https://www.readbyqxmd.com/read/29588327/educational-attainment-of-children-born-to-mothers-with-epilepsy
#12
Arron S Lacey, William Owen Pickrell, Rhys H Thomas, Mike P Kerr, Cathy P White, Mark I Rees
OBJECTIVE: Small prospective studies have identified that children exposed to valproate in utero have poorer scores on cognitive testing. We wanted to identify whether children exposed to antiepileptic drugs (AEDs) in utero have poorer school performance. METHODS: We used anonymised, linked, routinely collected healthcare records to identify children born to mothers with epilepsy. We linked these children to their national attainment Key Stage 1 (KS1) tests in mathematics, language and science at the age of 7 and compared them with matched children born to mothers without epilepsy, and with the national KS1 results...
March 27, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29564845/validation-of-field-methods-to-assess-body-fat-percentage-in-elite-youth-soccer-players
#13
Diego Munguia-Izquierdo, Luis Suarez-Arrones, Valter Di Salvo, Victor Paredes-Hernandez, Julian Alcazar, Ignacio Ara, Richard Kreider, Alberto Mendez-Villanueva
This study determined the most effective field method for quantifying body fat percentage in male elite youth soccer players and developed prediction equations based on anthropometric variables. Forty-four male elite-standard youth soccer players aged 16.3-18.0 years underwent body fat percentage assessments, including bioelectrical impedance analysis and the calculation of various skinfold-based prediction equations. Dual X-ray absorptiometry provided a criterion measure of body fat percentage. Correlation coefficients, bias, limits of agreement, and differences were used as validity measures, and regression analyses were used to develop soccer-specific prediction equations...
March 21, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29561225/cerebrovascular-blood-oxygenation-level-dependent-pulsatility-at-baseline-and-following-acute-exercise-among-healthy-adolescents
#14
Athena E Theyers, Benjamin I Goldstein, Arron Ws Metcalfe, Andrew D Robertson, Bradley J MacIntosh
Arterial stiffness is linked to cerebral small vessel damage and neurodegeneration, but barriers to accessing deep cerebrovascular anatomy limit our ability to assess the brain. This study describes an adaptation of a cardiac-related scrubbing method as a means of generating blood oxygenation level-dependent pulsatility maps based on the cardiac cycle. We examine BOLD pulsatility at rest, based on the non-parametric deviation from null metric, as well as changes following acute physiological stress from 20 min of moderate-intensity cycling in 45 healthy adolescents...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29553382/survival-in-patients-with-spinocerebellar-ataxia-types-1-2-3-and-6-eurosca-a-longitudinal-cohort-study
#15
Alhassane Diallo, Heike Jacobi, Arron Cook, Robyn Labrum, Alexandra Durr, Alexis Brice, Perrine Charles, Cecilia Marelli, Caterina Mariotti, Lorenzo Nanetti, Marta Panzeri, Maria Rakowicz, Anna Sobanska, Anna Sulek, Tanja Schmitz-Hübsch, Ludger Schöls, Holger Hengel, Bela Melegh, Alessandro Filla, Antonella Antenora, Jon Infante, José Berciano, Bart P van de Warrenburg, Dagmar Timmann, Sylvia Boesch, Massimo Pandolfo, Jörg B Schulz, Peter Bauer, Paola Giunti, Jun-Suk Kang, Thomas Klockgether, Sophie Tezenas du Montcel
BACKGROUND: Spinocerebellar ataxias are dominantly inherited progressive ataxia disorders that can lead to premature death. We aimed to study the overall survival of patients with the most common spinocerebellar ataxias (SCA1, SCA2, SCA3, and SCA6) and to identify the strongest contributing predictors that affect survival. METHODS: In this longitudinal cohort study (EUROSCA), we enrolled men and women, aged 18 years or older, from 17 ataxia referral centres in ten European countries; participants had positive genetic test results for SCA1, SCA2, SCA3, or SCA6 and progressive, otherwise unexplained, ataxias...
April 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29550052/airway-pathological-heterogeneity-in-asthma-visualization-of-disease-microclusters-using-topological-data-analysis
#16
Salman Siddiqui, Aarti Shikotra, Matthew Richardson, Emma Doran, David Choy, Alex Bell, Cary D Austin, Jeffrey Eastham-Anderson, Beverley Hargadon, Joseph R Arron, Andrew Wardlaw, Christopher E Brightling, Liam G Heaney, Peter Bradding
BACKGROUND: Asthma is a complex chronic disease underpinned by pathological changes within the airway wall. How variations in structural airway pathology and cellular inflammation contribute to the expression and severity of asthma are poorly understood. OBJECTIVES: Therefore we evaluated pathological heterogeneity using topological data analysis (TDA) with the aim of visualizing disease clusters and microclusters. METHODS: A discovery population of 202 adult patients (142 asthmatic patients and 60 healthy subjects) and an external replication population (59 patients with severe asthma) were evaluated...
March 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29524273/major-prognostic-factors-for-recurrence-and-survival-independent-of-the-american-joint-committee-on-cancer-eighth-edition-staging-system-in-patients-with-cutaneous-squamous-cell-carcinoma-treated-with-multimodality-therapy
#17
Melody J Xu, Ann A Lazar, Adam A Garsa, Sarah T Arron, William R Ryan, Ivan H El-Sayed, Jonathan R George, Alain P Algazi, Chase M Heaton, Patrick K Ha, Sue S Yom
BACKGROUND: The purpose of this study was to assess changes resulting from the American Joint Committee on Cancer (AJCC) eighth edition for cutaneous squamous cell carcinoma (SCC) and evaluate pertinent excluded factors. METHODS: In 101 patients receiving surgery and postoperative radiation, recurrence and survival were estimated by cumulative incidence and Kaplan-Meier method. Time-to-event analysis was performed using Cox proportional hazards and Fine-Gray competing risks regression models...
March 10, 2018: Head & Neck
https://www.readbyqxmd.com/read/29522561/socioeconomic-inequality-in-medication-persistence-in-primary-and-secondary-prevention-of-coronary-heart-disease-a-population-wide-electronic-cohort-study
#18
William King, Arron Lacey, James White, Daniel Farewell, Frank Dunstan, David Fone
BACKGROUND: Coronary heart disease (CHD) mortality in England fell by 36% between 2000 and 2007 and it is estimated that approximately 50% of the fall was due to improved treatment uptake. Marked socio-economic inequalities in CHD mortality in the United Kingdom (UK) remain, with higher age-adjusted rates in more deprived groups. Inequalities in the persistence of medication for primary and secondary prevention of CHD may contribute to the observed social gradient and we investigated this possibility in the population of Wales (UK)...
2018: PloS One
https://www.readbyqxmd.com/read/29516093/health-related-quality-of-life-in-patients-with-frontal-fibrosing-alopecia
#19
David Saceda-Corralo, Cristina Pindado-Ortega, Óscar Muñoz Moreno-Arrones, Pablo Fernández-González, Ana Rita Rodrigues-Barata, Pedro Jaén-Olasolo, Sergio Vañó-Galván
No abstract text is available yet for this article.
April 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29505636/characterizing-and-validating-stripe-rust-resistance-loci-in-us-pacific-northwest-winter-wheat-accessions-triticum-aestivum-l-by-genome-wide-association-and-linkage-mapping
#20
Weizhen Liu, Yukiko Naruoka, Kaitlin Miller, Kimberly A Garland-Campbell, Arron H Carter
Stripe rust resistance is a critical need for wheat cultivars in the US Pacific Northwest (PNW). Our previous genome-wide association study (GWAS) for stripe rust resistance in a set of PNW winter wheat accessions (Panel-2) identified multiple marker-trait associations (MTAs) for both all-stage and field resistance. In this study, we conducted additional GWAS using a different set of PNW winter wheat accessions (Panel-1) that contained recently bred soft white winter wheat breeding lines and cultivars. A total of 12 all-stage resistance MTAs and eight field resistance MTAs were identified...
March 2018: Plant Genome
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