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https://www.readbyqxmd.com/read/29245100/student-motivation-stressors-and-intent-to-leave-nursing-doctoral-study-a-national-study-using-path-analysis
#1
Delene Volkert, Lori Candela, Matthew Bernacki
BACKGROUND: The demand for doctorally prepared nurses worldwide is higher than ever. Universities have responded with increased numbers of DNP and Ph.D. in Nursing programs. There are more doctoral nursing students than ever before yet they remain one of the least studied student populations. This is concerning given the high attrition rates reported in doctoral programs. The few studies that do exist are typically qualitative and exploratory in nature. OBJECTIVES: The aim of this national study of Ph...
December 6, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29243250/a-camera-based-method-for-estimating-absolute-density-in-animals-displaying-home-range-behaviour
#2
Andrea Campos-Candela, Miquel Palmer, Salvador Balle, Josep Alós
1.The measurement of animal density may take advantage of recent technological achievements in wildlife video recording. Fostering the theoretical links between the patterns depicted by cameras and absolute density is required to exploit this potential. 2.We explore the applicability of the Hutchinson-Waser's postulate (i.e., when animal density is stationary at a given temporal and spatial scale, the absolute density is given by the average number of animals counted per frame), which is a counter-intuitive statement for most ecologists and managers who are concerned with counting the same individual more than once...
December 15, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29236839/ostomy-patients-perception-of-the-health-care-received
#3
Candela Bonill-de Las Nieves, Concepción Capilla Díaz, Miriam Celdrán-Mañas, José Miguel Morales-Asencio, Sandra Milena Hernández-Zambrano, César Hueso-Montoro
AIM: to describe ostomy patient's perception about health care received, as well as their needs and suggestions for healthcare system improvement. METHOD: qualitative phenomenological study was conducted, involving individual and semi-structured interviews on the life experiences of 21 adults who had a digestive stoma. Participants were selected following a purposive sampling approach. The analysis was based on the constant comparison of the data, the progressive incorporation of subjects and triangulation among researchers and stoma therapy nurses...
December 11, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29234708/simple-and-rapid-validated-hplc-fluorescence-determination-of-perampanel-in-the-plasma-of-patients-with-epilepsy
#4
Susan Mohamed, Carmina Candela, Roberto Riva, Manuela Contin
We present a simple and fast high-performance liquid chromatography method with fluorescence detection for the determination of the antiepileptic drug perampanel in human plasma. The chromatographic separation was performed on a Kinetex PFP (100 × 2.6 mm, 4.6 µm) column, using a mobile phase of sodium acetate 0.03 M pH 3.7 and acetonitrile (40/60, v/v), at a flow rate of 0.8 mL/min. Total chromatography time for each run was 5 min. Sample preparation (250 µL) involved only one simple precipitation step by acetonitrile spiked with mirtazapine as internal standard...
March 2018: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/29224733/validated-maldi-tof-ms-method-for-anthrax-lethal-factor-provides-early-diagnosis-and-evaluation-of-therapeutics
#5
Maribel Gallegos-Candela, Anne E Boyer, Adrian R Woolfitt, Judy Brumlow, Renato C Lins, Conrad P Quinn, Alex R Hoffmaster, Gabriel Meister, John R Barr
Anthrax lethal factor (LF) is a zinc-dependent endoprotease and a critical virulence factor for Bacillus anthracis, the causative agent of anthrax. The mass spectrometry (MS) method for total-LF quantification includes three steps; 1) LF specific antibody capture/concentration, 2) LF-specific hydrolysis of a peptide substrate, and 3) detection and quantification of LF-cleaved peptides by isotope-dilution MALDI-TOF/MS. Recombinant LF spiked plasma was used for calibration and quality control (QC) materials. Specificity was 100% from analysis of serum and plasma from 383 non-infected humans, 31 rabbits, and 24 rhesus macaques...
December 7, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29209028/suitability-of-two-distinct-approaches-for-the-high-throughput-study-of-the-post-embryonic-effects-of-embryo-lethal-mutations-in-arabidopsis
#6
Tamara Muñoz-Nortes, Héctor Candela, José Luis Micol
Several hundred genes are required for embryonic and gametophytic development in the model plant Arabidopsis thaliana, as inferred from the lethality of their mutations. Despite many of these genes are expressed throughout the plant life cycle, the corresponding mutants arrest at early stages, preventing the study of their post-embryonic functions by conventional methods. Clonal analysis represents an effective solution to this problem by uncovering the effects of embryo-lethal mutations in sectors of mutant cells within an otherwise normal adult plant...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206137/analysis-of-fresnel-zone-plates-focusing-dependence-on-operating-frequency
#7
José Miguel Fuster, Pilar Candelas, Sergio Castiñeira-Ibáñez, Sergio Pérez-López, Constanza Rubio
The focusing properties of Fresnel Zone Plates (FZPs) against frequency are analyzed in this work. It is shown that the FZP focal length depends almost linearly on the operating frequency. Focal depth and focal distortion are also considered, establishing a limit on the frequency span at which the operating frequency can be shifted. An underwater FZP ultrasound focusing system is demonstrated, and experimental results agree with the theoretical analysis and simulations.
December 5, 2017: Sensors
https://www.readbyqxmd.com/read/29201144/length-of-stay-costs-and-complications-in-lumbar-disc-herniation-surgery-by-standard-plif-versus-a-new-dynamic-interspinous-stabilization-technique
#8
Manuel Segura-Trepichio, David Candela-Zaplana, José Manuel Montoza-Nuñez, Antonio Martin-Benlloch, Andreu Nolasco
Background: The number of lumbar spine surgeries has been increasing during the last 20 years, which also leads to an increase in hospital costs and complications related to surgery. Therefore, there is a greater concern about the costs and safety of the techniques and implants used. Methods: Patients (aged from 18 to 50 years) presenting with lumbago /sciatica (ICD-10-CM M54.3, M54.4) due to lumbar disc herniation lasting more than 12 weeks, were included. Patients with disc herniation larger than size-2 or size-3 according to the MSU Classification were eligible for participation...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29201037/transcriptomic-response-of-resistant-pi613981-malus-sieversii-and-susceptible-royal-gala-genotypes-of-apple-to-blue-mold-penicillium-expansum-infection
#9
Ana-Rosa Ballester, John Norelli, Erik Burchard, Ahmed Abdelfattah, Elena Levin, Luis González-Candelas, Samir Droby, Michael Wisniewski
Malus sieversii from Central Asia is a progenitor of the modern domesticated apple (Malus × domestica). Several accessions of M. sieversii are highly resistant to the postharvest pathogen Penicillium expansum. A previous study identified the qM-Pe3.1 QTL on LG3 for resistance to P. expansum in the mapping population GMAL4593, developed using the resistant accession, M. sieversii -PI613981, and the susceptible cultivar "Royal Gala" (RG) (M. domestica), as parents. The goal of the present study was to characterize the transcriptomic response of susceptible RG and resistant PI613981 apple fruit to wounding and inoculation with P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29146865/echocardiographic-changes-with-non-invasive-ventilation-and-cpap-in-obesity-hypoventilation-syndrome
#10
Jaime Corral, Maria Victoria Mogollon, M-Ángeles Sánchez-Quiroga, Javier Gómez de Terreros, Auxiliadora Romero, Candela Caballero, Joaquin Teran-Santos, María L Alonso-Álvarez, Teresa Gómez-García, Mónica González, Soledad López-Martínez, Pilar de Lucas, José M Marin, Odile Romero, Trinidad Díaz-Cambriles, Eusebi Chiner, Carlos Egea, Roberto M Lang, Babak Mokhlesi, Juan F Masa
RATIONALE: Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. OBJECTIVES: We performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes...
November 16, 2017: Thorax
https://www.readbyqxmd.com/read/29139642/matrilineal-heritage-in-southern-iberia-reveals-deep-genetic-links-between-continents
#11
Candela L Hernández, Rosario Calderón
Within the Mediterranean Basin, the Iberian Peninsula has been a focus of attraction for several cultures and civilizations from its prehistory and history, making it a target territory for studying human migration patterns and peopling processes using a wide and heterogeneous spectrum of genomic markers. While its Cantabrian fringe represents the most regularly analysed area in terms of its mitochondrial diversity, the absence of monographic surveys on the maternal genetic composition of southern Iberians (i...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29115899/therapeutic-inhibitors-for-the-treatment-of-dry-eye-syndrome
#12
Candela Rodríguez-Pomar, Jesus Pintor, Basilio Colligris, Gonzalo Carracedo
Dry eye disease (DED), defined as a multifactorial disease of tears and ocular surface, results in symptoms of discomfort, ocular irritation, visual disturbance and tear film instability. This syndrome is accompanied of ocular surface inflammation and it is produced by a deficient activity of the lacrimal functional unit. In addition, it is associated with systemic autoimmune diseases such as Sjögren´s Syndrome, rheumatoid arthritis, systemic lupus erythematosus and some drug administration. The treatment of dry eye disease is based on the typical signs and symptoms of dry eye, which are associated with hyperosmolarity, ocular surface inflammation, discomfort, visual disturbance, and tear film instability...
November 14, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29114246/variation-of-carbohydrate-active-enzyme-patterns-in-the-gut-microbiota-of-italian-healthy-subjects-and-type-2-diabetes-patients
#13
Matteo Soverini, Silvia Turroni, Elena Biagi, Sara Quercia, Patrizia Brigidi, Marco Candela, Simone Rampelli
The human gut microbiota (GM) has been associated, to date, with various complex functions, essentials for the host health. Among these, it is certainly worth noting the degradation of the so-called microbiota-accessible carbohydrates (MACs), which the GM breaks down through specific enzymes, referred to as carbohydrate-active enzymes (CAZymes). This degradation constitutes the first step in the production of short-chain fatty acids (SCFAs), key microbial small molecules having multiple health-promoting effects for the host organism...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29113294/therapeutic-management-and-one-year-outcomes-in-elderly-patients-with-acute-coronary-syndrome
#14
Esteban Orenes-Piñero, Juan M Ruiz-Nodar, María Asunción Esteve-Pastor, Miriam Quintana-Giner, José Miguel Rivera-Caravaca, Andrea Veliz, Mariano Valdés, Manuel Macías, Vicente Pernias-Escrig, Nuria Vicente-Ibarra, Luna Carrillo, Miriam Sandín-Rollán, Elena Candela, Teresa Lozano, Francisco Marín
Background: Elderly represents a subgroup of high-risk ACS patients due to their advanced age and other comorbidities. Unfortunately, they are also often under-represented in many studies and clinical trials. Furthermore, cardiologists commonly find difficulties in the choice of the antiplatelet treatment and even on whether invasive revascularization should be used. In this study, the management of elderly ACS patients regarding antiplatelet therapy and revascularization procedures will be analyzed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112133/characterization-of-sheep-wool-as-a-sustainable-material-for-acoustic-applications
#15
Romina Del Rey, Antonio Uris, Jesús Alba, Pilar Candelas
In recent years, natural materials are becoming a valid alternative to traditional sound absorbers due to reduced production costs and environmental protection. This paper reports the acoustical characterization of sheep wool. Measurements on normal incidence and diffuse-incidence sound absorption coefficients of different samples are reported. The airflow resistance has also been measured. The results prove that sheep wool has a comparable sound absorption performance to that of mineral wool or recycled polyurethane foam...
November 7, 2017: Materials
https://www.readbyqxmd.com/read/29084256/identification-and-characterization-of-lysm-effectors-in-penicillium-expansum
#16
Elena Levin, Ana Rosa Ballester, Ginat Raphael, Oleg Feigenberg, Yongsheng Liu, John Norelli, Luis Gonzalez-Candelas, Jing Ma, Christopher Dardick, Michael Wisniewski, Samir Droby
P. expansum is regarded as one of the most important postharvest rots of apple fruit and is also of great concern to fruit processing industries. Elucidating the pathogenicity mechanism of this pathogen is of utmost importance for the development of effective and safe management strategies. Although, many studies on modification of the host environment by the pathogen were done, its interactions with fruit during the early stages of infection and the virulence factors that mediate pathogenicity have not been fully defined...
2017: PloS One
https://www.readbyqxmd.com/read/29078992/prevalence-of-d-fragilis-infection-in-the-household-contacts-of-a-group-of-infected-patients
#17
Candela Menéndez Fernández-Miranda, Jonathan Fernández-Suarez, Mercedes Rodríguez-Pérez, Pablo Menéndez Fernández-Miranda, Fernando Vázquez, Jose A Boga Ribeiro, Azucena Rodríguez-Guardado
INTRODUCTION: The results of a study on the household contacts of patients with D. fragilis infection are presented. METHODS: A prospective, descriptive study was carried out on all Dientamoeba fragilis-infected patients treated at the Tropical Medicine Unit of Hospital Universitario Central de Asturias between 2012- 2017 and their household contacts. Three stool samples per patient and three stool samples from each of their household contacts were concentrated and analysed...
October 24, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29058382/risk-factors-of-leptospira-infection-in-mediterranean-periurban-micromammals
#18
J Millán, A Cevidanes, A D Chirife, M G Candela, L León-Vizcaíno
Urbanization of natural areas can change abiotic factors, providing artificial sources of humidity in summer and decreasing variation of temperatures in winter. Our study aimed at document risk factors of infection in mammal reservoirs of pathogenic Leptospira in the human/wildlife interface of a large metropolitan area. We hypothesize that survival of Leptospira and thus their prevalence in animal reservoirs should be higher in residential areas than in natural habitats, especially after the hot, dry Mediterranean summers...
October 23, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29050679/glycaemic-control-of-elderly-patients-with-type-2-diabetes-mellitus-in-spain-2015-and-its-relationship-with-functional-capacity-and-comorbidity-the-escadiane-study
#19
F J Sangrós-González, J Martínez-Candela, L Avila-Lachica, J Díez-Espino, J M Millaruelo-Trillo, J García-Soidán, L Carrillo Fernández, P Ezkurra Loiola
OBJECTIVES: To understand the state of glycaemic control of elderly patients with type 2 diabetes mellitus in Spain and its relationship with functional capacity and comorbidity. METHODS: Cross-sectional, observational, multicentre national study on patients with diabetes mellitus aged 65 years or older. The study analysed demographic and anthropometric variables, cardiovascular risk factors, clinical and laboratory data, associated comorbidity and treatments. We analysed the functional capacity using the Barthel index and the comorbidity with Charlson index...
October 16, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/29038356/local-production-of-neurostradiol-affects-gonadotropin-releasing-hormone-gnrh-secretion-at-mid-gestation-in-lagostomus-maximus-rodentia-caviomorpha
#20
Santiago E Charif, Pablo I F Inserra, Alejandro R Schmidt, Noelia P Di Giorgio, Santiago A Cortasa, Candela R Gonzalez, Victoria Lux-Lantos, Julia Halperin, Alfredo Daniel Vitullo, Verónica B Dorfman
Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arising from the reactivation of the hypothalamic-hypophyseal-ovary (H.H.O.) axis. Estradiol (E2) regulates gonadotropin-releasing hormone (GnRH) expression. Biosynthesis of estrogens results from the aromatization of androgens by aromatase, which mainly occurs in the gonads, but has also been described in the hypothalamus...
October 2017: Physiological Reports
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