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M Sánchez Mollá, I Candela García, F J Gómez-Romero, D Orozco Beltrán, M Ollero Baturone
OBJECTIVE: To determine the prevalence of patients with multiple chronic diseases in Primary Care using the multiple morbidity criteria and Clinical Risk Groups, and the agreement in identifying high-risk patients that require case management with both methods. MATERIAL AND METHOD: A cross-sectional study was conducted on 240 patients, selected by random sampling of 16 care quotas from two Primary Health Care centres of a health area. Informed consent was obtained to access their electronic medical records for the study, and a record was made of age, sex, health status of Clinical Risk Groups, severity, multiple morbidity criteria, and Charlson index by physicians during clinical practice...
October 14, 2016: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
Andrea E Scaramuzza, Claudia Arnaldi, Valentino Cherubini, Elvira Piccinno, Ivana Rabbone, Sonia Toni, Stefano Tumini, Gliberto Candela, Paola Cipriano, Lucia Ferrito, Lorenzo Lenzi, Davide Tinti, Ohad Cohen, Fortunato Lombardo
No abstract text is available yet for this article.
October 15, 2016: Acta Diabetologica
Candela R González, Mariano Ar Amer, Alfredo D Vitullo, Silvia I González-Calvar, María I Vacas
Saliva is the first barrier to entry of bacteria and viruses into the body. The submandibular glands (SMG) contribute to the maintenance of oral health and regulation of immune/ inflam matory responses. Previous studies suggest that transforming growth factor beta 1 (TGFB1) may contribute to salivary gland fibrosis but the expression of the TGFB1 system in the SMG has not been elucidated. Thus, the aim of this study was to analyze in rat SMG the immunolocalization of TGFB1 and its specific receptors ALK5 (profibrotic) and ALK1 (proproliferative) and the coreceptor endoglin (EDG) in a bilateral experimental periodontitis (EP) model (cotton thread ligature around the neck of the first lower molars) for 1 and 6 weeks...
September 2016: Acta Odontológica Latinoamericana: AOL
Emma Barahona, Ana Navazo, Daniel Garrido-Sanz, Candela Muriel, Francisco Martínez-Granero, Miguel Redondo-Nieto, Marta Martín, Rafael Rivilla
The genomic sequence of Pseudomonas fluorescens F113 has shown the presence of a 41 kb cluster of genes that encode the production of a second flagellar apparatus. Among 2,535 pseudomonads strains with sequenced genomes, these genes are only present in the genomes of F113 and other six strains, all but one belonging to the P. fluorescens cluster of species, in the form of a genetic island. The genes are homologous to the flagellar genes of the soil bacterium Azotobacter vinelandii. Regulation of these genes is mediated by the flhDC master operon, instead of the typical regulation in pseudomonads, which is through fleQ...
2016: Frontiers in Microbiology
I Cuesta López, M Sánchez Cuervo, Á Candela Toha, J Benedí González, T Bermejo Vicedo
WHAT IS KNOWN AND OBJECTIVE: The correct management of high-alert medications is a priority issue in expert recommendations for improving the clinical safety of patients. Objectives were to assess the impact of the implementation of vasoactive drug (VAD) protocols on safety and efficacy in the treatment of critically ill patients. METHODS: A prospective before-and-after study on the implementation of different VAD protocols, comparing medication errors (MEs) rates, mean intensive care unit (ICU) stay, mean blood pressure (MAP), heart rate (HR) and oxygen saturation...
October 4, 2016: Journal of Clinical Pharmacy and Therapeutics
S Gumina, V Candela, D Passaretti
We observed the clinical course, in the short-medium term, of patients with voluminous type II acromio-clavicular (AC) joint cyst who underwent aspiration and steroid injection regarded as the only possible treatment to avoid possible skin complications. Four patients (7.4% of cases described in literature) (3F-1M ; mean age 83 years, range : 78-87 years) with a voluminous ( > 7 cm) oval, no mobile, no fluctuant cyst overlying the AC joint, were retrospectively observed. The patients, judged by the anesthesiologist as ASA 3-4 patients, were merely submitted to cyst aspiration and steroid injection...
August 2016: Acta Orthopaedica Belgica
Giuseppina Zirilli, Giuseppina Salzano, Domenico Corica, Claudia Ventrici, Gilberto Candela, Federica Porcaro
BACKGROUND: It is not well known whether the association with Down's syndrome (DS) may be able to affect the phenotypic expression of Hashimoto's thyroiditis (HT). OBJECTIVES: To review the most recent literature data about the specific peculiarities of HT in DS children. DESIGN: The main epidemiological features of DS-related HT were compared with those generally reported in HT children without DS. The prevalence rates of the different thyroid function patterns detected at the time of HT diagnosis and five years later were summarized in Tables 1 and 2...
2016: Acta Bio-medica: Atenei Parmensis
Silvia Turroni, Jessica Fiori, Simone Rampelli, Stephanie L Schnorr, Clarissa Consolandi, Monica Barone, Elena Biagi, Flaminia Fanelli, Marco Mezzullo, Alyssa N Crittenden, Amanda G Henry, Patrizia Brigidi, Marco Candela
The recent characterization of the gut microbiome of traditional rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbiome in complementing our physiology, opening up significant questions on how the microbiota changes that have occurred in industrialized urban populations may have altered the microbiota-host co-metabolic network, contributing to the growing list of Western diseases. Here, we applied a targeted metabolomics approach to profile the fecal metabolome of the Hadza of Tanzania, one of the world's few remaining foraging populations, and compared them to the profiles of urban living Italians, as representative of people in the post-industrialized West...
2016: Scientific Reports
Juan F Masa, Jaime Corral, Auxiliadora Romero, Candela Caballero, Joaquin Terán-Santos, Maria L Alonso-Álvarez, Teresa Gomez-Garcia, Mónica González, Soledad López-Martínez, Pilar De Lucas, José M Marin, Sergi Marti, Trinidad Díaz-Cambriles, Eusebi Chiner, Miguel Merchan, Carlos Egea, Ana Obeso, Babak Mokhlesi
RATIONALE: Low flow supplemental oxygen is commonly prescribed to patients with obesity hypoventilation syndrome (OHS). However, there is a paucity of data regarding its efficacy and safety. OBJECTIVES: To assess the medium-term treatment efficacy of adding supplemental oxygen therapy to commonly prescribed treatment modalities in OHS. METHODS: In this post hoc analysis of a previous randomized controlled trial, we studied 302 sequentially screened OHS patients who were randomly assigned to noninvasive ventilation, continuous positive airway pressure, or lifestyle modification...
August 22, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Candelas Pérez Del Villar, Raquel Yotti, María Ángeles Espinosa, Enrique Gutiérrez-Ibañes, Alicia Barrio, María José Lorenzo, Pedro Luis Sánchez Fernández, Yolanda Benito, Raquel Prieto, Esther Pérez David, Pablo Martínez-Legazpi, Francisco Fernández-Avilés, Javier Bermejo
OBJECTIVES: The goal of this study was to determine the functional impact of paradoxical low-gradient aortic stenosis (PLGAS) and clarify whether the relevance of the valvular obstruction is related to baseline flow. BACKGROUND: Establishing the significance of PLGAS is particularly challenging. METHODS: Twenty symptomatic patients (77 ± 6 years of age; 17 female subjects) with PLGAS (mean gradient 28 ± 6 mm Hg; aortic valve area 0.8 ± 0...
August 20, 2016: JACC. Cardiovascular Imaging
G Candelas, V Villaverde, S García, M Guerra, M J León, J D Cañete
The aim of this study was to systematically review the literature available about the benefit of health education by a training nurse in patients with axial and/or peripheral psoriatic arthritis in the framework of the drawing up of the axial spondyloarthritis and psoriatic arthritis guidelines of the "Spanish Society of Rheumatology". Electronic databases (Cochrane Central Register of Controlled Trials, EMBASE, Medline/PubMed, CINAHL) were systematically searched from inception to 2014 using medical subject headings and keywords...
November 2016: Rheumatology International
Eléonore Bouguyon, Francine Perrine-Walker, Marjorie Pervent, Juliette Rochette, Candela Cuesta, Eva Benkova, Alexandre Martinière, Lien Bach, Gabriel Krouk, Alain Gojon, Philippe Nacry
Plants are able to modulate root growth and development to optimize their nitrogen nutrition. In Arabidopsis (Arabidopsis thaliana), the adaptive root response to nitrate (NO3(-)) depends on the NRT1.1/NPF6.3 transporter/sensor. NRT1.1 represses emergence of lateral root primordia (LRPs) at low concentration or absence of NO3(-) through its auxin transport activity that lowers auxin accumulation in LR. However, these functional data strongly contrast with the known transcriptional regulation of NRT1.1, which is markedly repressed in LRPs in the absence of NO3(-) To explain this discrepancy, we investigated in detail the spatiotemporal expression pattern of the NRT1...
October 2016: Plant Physiology
Josefa Marcos-Sanmartín, José Antonio López Fernández, José Sánchez-Payá, Óscar Cruz Piñero-Sánchez, María José Román-Sánchez, María Asunción Quijada-Cazorla, María Amparo Candela-Hidalgo, Juan Carlos Martínez-Escoriza
OBJECTIVE: The purpose of this study was to compare the long-term safety, disease-free survival, and recurrence rate of total laparoscopic hysterectomy using uterine manipulator and abdominal hysterectomy in the surgical treatment in early-stage endometrial cancer. STUDY DESIGN: This was a cohort study of 147 patients with clinical endometrial cancer (laparoscopic surgery group, 77 women; laparotomy group, 70 women). Data were evaluated and analyzed by intention-to-treat principle, and survival data of stage I endometrial cancer (129 patients; 66 from laparoscopic surgery group and 60 from laparotomy group) were estimated by using the Kaplan-Meier curves...
August 11, 2016: International Journal of Gynecological Cancer
S Gumina, P Baudi, V Candela, G Campochiaro
OBJECTIVE: To compare clinical outcomes and complication rates in the medium-to-long-term follow-up of Hertel 7 humeral head fractures treated with two different locking plates. MATERIALS AND METHODS: A total of 52 patients with type 7 humeral head fracture (in accordance with Hertel classification) were enrolled retrospectively: 24 patients [4 male, 20 female; mean age (standard deviation [SD]): 68.9 (5.8) years] were treated with Diphos H plate (Group A) and 28 patients [6 male, 22 female; mean age (SD): 61...
August 3, 2016: Injury
Javier Aranceta-Bartrina, Ángel Gil, Ascensión Marcos, Carmen Pérez-Rodrigo, Lluis Serra-Majem, Gregorio Varela-Moreiras
Javier Aranceta-Bartrina1, Ángel Gil2, Ascensión Marcos3, Carmen Pérez-Rodrigo4, Lluis Serra-Majem5 and Gregorio Varela-Moreiras6*1Associate Professor at University of Navarra. Pamplona, Spain. 2Professor of Biochemistry and Molecular Biology. University of Granada. Granada, Spain. 3Research Professor at the Spanish National Research Council (CSIC). Madrid, Spain. 4President of Spanish Society of Community Nutrition (SENC). Bilbao, Spain. 5Professor of Preventive Medicine and Public Health. Director of Group of Nutrition...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Nieves Candelas González, Josefina Rascón Pérez, Beatriz Chamero, Oscar Cambra-Moo, Armando González Martín
The methodology for sex determination in human skeletal remains depends on the different bone morphologies presented by men and women. Due to their direct implications in reproduction, the whole pelvis, particularly the os coxae, shows different characteristics in either sex. The sacrum and the os coxae constitute the birth canal. In this research study, the os coxae shape is analyzed using geometric morphometrics, providing information on morphology, regardless of size or any other factor beyond the geometry itself...
August 3, 2016: Journal of Anatomy
Matteo Soverini, Simone Rampelli, Silvia Turroni, Stephanie L Schnorr, Sara Quercia, Andrea Castagnetti, Elena Biagi, Patrizia Brigidi, Marco Candela
Studies of the gut microbiome variation among human populations revealed the existence of robust compositional and functional layouts matching the three subsistence strategies that describe a trajectory of changes across our recent evolutionary history: hunting and gathering, rural agriculture, and urban post-industrialized agriculture. In particular, beside the overall reduction of ecosystem diversity, the gut microbiome of Western industrial populations is typically characterized by the loss of Treponema and the acquisition of Bifidobacterium as an abundant inhabitant of the post-weaning gut microbial ecosystem...
2016: Frontiers in Microbiology
Pedro Moya, Marta Bellon, Antonio Arroyo, Isabel Galindo, Fernando Candela, Javier Lacueva, Rafael Calpena
BACKGROUND/AIMS: Most cases of diverticular inflammation are mild and require only medical treatment with liquid diet and antibiotics. Until recently, this treatment required admission to hospitals, which consequently entailed costs. In most cases, treatment was conservative, and less than a quarter of patients admitted actually underwent surgery. In the last year, the outpatient treatment of these patients with uncomplicated diverticulitis has proven effective and safe. The aim of the present study was to describe our experience after 5 years of outpatient treatment with oral antibiotics...
July 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Javier Aranceta-Bartrina, Ángel Gil, Ascensión Marcos, Carmen Pérez-Rodrigo, Lluis Serra-Majem, Gregorio Varela-Moreiras
Javier Aranceta-Bartrina1, Ángel Gil2, Ascensión Marcos3, Carmen Pérez-Rodrigo4, Lluis Serra-Majem5 and Gregorio Varela-Moreiras6*1Associate Professor at University of Navarra. Pamplona, Spain. 2Professor of Biochemistry and Molecular Biology. University of Granada. Granada, Spain. 3Research Professor at the Spanish National Research Council (CSIC). Madrid, Spain. 4President of Spanish Society of Community Nutrition (SENC). Bilbao, Spain. 5Professor of Preventive Medicine and Public Health. Director of Group of Nutrition...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Ana Clopes, Montse Gasol, Rosana Cajal, Luis Segú, Ricard Crespo, Ramón Mora, Susana Simon, Luis A Cordero, Candela Calle, Antoni Gilabert, Josep R Germà
BACKGROUND: In 2011 the first payment-by-results (PbR) scheme in Catalonia was signed between the Catalan Institute of Oncology (ICO), the Catalan Health Service, and AstraZeneca (AZ) for the introduction of gefitinib in the treatment of advanced EGFR-mutation positive non-small-cell lung cancer. The PbR scheme includes two evaluation points: at week 8, responses, stabilization and progression were evaluated, and at week 16 stabilization was confirmed. AZ was to reimburse the total treatment cost of patients that failed treatment, defined as progression at weeks 8 or 16...
July 21, 2016: Journal of Medical Economics
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