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https://www.readbyqxmd.com/read/29038356/local-production-of-neurostradiol-affects-gonadotropin-releasing-hormone-gnrh-secretion-at-mid-gestation-in-lagostomus-maximus-rodentia-caviomorpha
#1
Santiago E Charif, Pablo I F Inserra, Alejandro R Schmidt, Noelia P Di Giorgio, Santiago A Cortasa, Candela R Gonzalez, Victoria Lux-Lantos, Julia Halperin, Alfredo Daniel Vitullo, Verónica B Dorfman
Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arising from the reactivation of the hypothalamic-hypophyseal-ovary (H.H.O.) axis. Estradiol (E2) regulates gonadotropin-releasing hormone (GnRH) expression. Biosynthesis of estrogens results from the aromatization of androgens by aromatase, which mainly occurs in the gonads, but has also been described in the hypothalamus...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29032502/gut-microbiota-changes-in-the-extreme-decades-of-human-life-a-focus-on-centenarians
#2
REVIEW
Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which contributes to a variety of physiological functions. The GM is highly dynamic, being sensitive to environmental stimuli, and its composition changes over the host's entire lifespan. However, the basic question of how much these changes may be ascribed to variables such as population, diet, genetics and gender, and/or to the aging process per se is still largely unanswered. We argue that comparison among studies on centenarians-the best model of healthy aging and longevity-recruited from different geographical areas/populations (different genetics and dietary habits) can help to disentangle the contribution of aging and non-aging-related variables to GM remodeling with age...
October 14, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28978126/socioeconomic-deprivation-worsens-the-outcomes-of-italian-women-with-hormone-receptor-positive-breast-cancer-and-decreases-the-possibility-of-receiving-standard-care
#3
Francesca Di Salvo, Nicola Caranci, Teresa Spadea, Nicolas Zengarini, Pamela Minicozzi, Hade Amash, Mario Fusco, Fabrizio Stracci, Fabio Falcini, Claudia Cirilli, Giuseppina Candela, Rosanna Cusimano, Rosario Tumino, Milena Sant
BACKGROUND: Socioeconomic factors influence access to cancer care and survival. This study investigated the role of socioeconomic status on the risk of breast cancer recurrence and on the delivery of appropriate cancer care (sentinel lymph node biopsy and breast-conserving surgery plus radiotherapy), by patients' age and hormone receptor status. METHODS: 3,462 breast cancer cases diagnosed in 2003-2005 were selected from 7 Italian cancer registries and assigned to a socioeconomic tertile on the basis of the deprivation index of their census tract...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967228/characterization-of-the-human-dna-gut-virome-across-populations-with-different-subsistence-strategies-and-geographical-origin
#4
Simone Rampelli, Silvia Turroni, Stephanie L Schnorr, Matteo Soverini, Sara Quercia, Monica Barone, Andrea Castagnetti, Elena Biagi, Giorgio Gallinella, Patrizia Brigidi, Marco Candela
It is a matter of fact that the human gut microbiome also includes a non-bacterial fraction represented by eukaryotic cells and viruses. To further explore the gut microbiome variation in human populations, here we characterized the human DNA viral community from publicly available gut metagenome datasets from human populations with different geographical origin and lifestyle. In particular, such datasets encompass microbiome information from two western urban societies (USA and Italy), as well as two traditional hunter-gatherer communities (the Hadza from Tanzania and Matses from Peru) and one pre-agricultural tribe (Tunapuco from Peru)...
October 2, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28948365/genotypes-and-subgenotypes-of-hepatitis-b-virus-circulating-in-an-endemic-area-in-peru
#5
Max Carlos Ramírez-Soto, Maria Alma Bracho, Fernando González-Candelas, Milagros Huichi-Atamari
Although hepatitis B virus (HBV) infection is still endemic in Abancay, Peru, two decades after vaccination against hepatitis B started in the area, little is known about the diversity and circulation of genotypes and subgenotypes of the virus. To identify the genotypes and subtypes of HBV circulating in Abancay, complete genome sequences of 11 treatment-naive HBV-infected patients were obtained, and phylogenetic analysis was conducted with these and additional sequences from GenBank. Genotyping revealed the presence of genotype F in all the samples from Abancay...
September 25, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28941893/unravelling-the-contribution-of-the-penicillium-expansum-peste12-transcription-factor-to-virulence-during-apple-fruit-infection
#6
Paloma Sánchez-Torres, Laura Vilanova, Ana Rosa Ballester, Mario López-Pérez, Neus Teixidó, Inmaculada Viñas, Josep Usall, Luis González-Candelas, Rosario Torres
Blue mould disease caused by Penicillium expansum infection is one of the most important diseases of pome fruit accounting for important economic losses. In the present study, the PeSte12 transcription factor gene was identified, and deletant mutants were produced by gene replacement. Knockout mutants showed a significant decrease of virulence during apple fruit infection. Virulence was affected by the maturity stage of the fruit (immature, mature and over-mature), and disease severity was notably reduced when the apples were stored at 0 °C...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28920084/effects-of-methamphetamine-on-locomotor-activity-and-thalamic-gene-expression-in-leptin-deficient-obese-mice
#7
Betina González, Candela González, Verónica Bisagno, Francisco J Urbano
Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons. The leptin deficient mouse (ob/ob) has been used as an animal model of blunted leptin action, and presents with obesity and mild type 2 diabetes. We used ob/ob mice to study the effect of repeated 7-day methamphetamine (METH) administration analyzing locomotion, behavioral sensitization, and somatosensory thalamic mRNA expression of voltage-gated calcium channels and glutamatergic receptors using RT-PCR...
July 2017: Translational Brain Rhythmicity
https://www.readbyqxmd.com/read/28912478/the-molecular-epidemiology-of-hiv-1-in-the-comunidad-valenciana-spain-analysis-of-transmission-clusters
#8
Juan Ángel Patiño-Galindo, Manoli Torres-Puente, María Alma Bracho, Ignacio Alastrué, Amparo Juan, David Navarro, María José Galindo, Dolores Ocete, Enrique Ortega, Concepción Gimeno, Josefina Belda, Victoria Domínguez, Rosario Moreno, Fernando González-Candelas
HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874227/the-impact-of-virus-population-diversity-on-the-dynamics-of-cytomegalovirus-dnaemia-in-allogeneic-stem-cell-transplant-recipients
#9
Víctor Vinuesa, María Alma Bracho, Eliseo Albert, Carlos Solano, Manuela Torres-Puente, Estela Giménez, Fernando González-Candelas, David Navarro
Mixed cytomegalovirus (CMV) infections are associated with delayed viral clearance in solid organ transplant recipients. We investigated whether this could be extrapolated to allogeneic stem cell transplant (allo-SCT) recipients. A total of 48 plasma specimens, obtained during 29 episodes of active CMV infection in 25 non-consecutive allo-SCT patients, were analysed. Baseline blood specimens, drawn shortly prior to the inception of pre-emptive antiviral therapy (pre-treatment specimen; n=29), as well as follow-up samples obtained either after the initiation of antiviral therapy (post-treatment specimen; n=15) or during recurrent episodes (n=4) were analysed...
September 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28852094/unraveling-the-gut-microbiome-of-the-long-lived-naked-mole-rat
#10
Tewodros Debebe, Elena Biagi, Matteo Soverini, Susanne Holtze, Thomas Bernd Hildebrandt, Claudia Birkemeyer, Dereje Wyohannis, Alemayehu Lemma, Patrizia Brigidi, Vulk Savkovic, Brigitte König, Marco Candela, Gerd Birkenmeier
The naked mole-rat (Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer. These features make this wild rodent an excellent model to study the biology of healthy aging and longevity. Here we characterize for the first time the intestinal microbial ecosystem of the naked mole-rat in comparison to humans and other mammals, highlighting peculiarities related to the specific living environment, such as the enrichment in bacteria able to utilize soil sulfate as a terminal electron acceptor to sustain an anaerobic oxidative metabolism...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845856/-web-based-collection-of-educational-needs-in-a-medicine-department-an-intranet-survey-for-planning-cme-corse
#11
Laura Morbidoni, Massimiliano Correani, Marco Candela
INTRODUCTION: Few evidences about methods to harvest educational needs by health care professionals in internal medicine have been published. In this project the following objectives have been pursued: to express preferences by each health care worker; to evaluate the efficacy of an intranet-based survey in order to structure continuing medical education (CME) planning. METHODS: We created a form based on 7 questions, exploring the following areas: knowledge, know-how, communication, transversal competencies...
July 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28837206/neutrophil-extracellular-traps-are-increased-in-patients-with-acute-ischemic-stroke-prognostic-significance
#12
Juana Vallés, Aída Lago, María Teresa Santos, Ana María Latorre, José I Tembl, Juan B Salom, Candela Nieves, Antonio Moscardó
Neutrophil extracellular traps (NETs) are networks of DNA, histones, and proteolytic enzymes produced by activated neutrophils through different mechanisms. NET formation is promoted by activated platelets and can in turn activate platelets, thus favoring thrombotic processes. NETs have been detected in venous and arterial thrombosis, but data in stroke are scarce. The aim of this study was to evaluate NETs in the plasma of patients with acute ischemic stroke and their potential association with baseline clinical characteristics, stroke severity, and one-year clinical outcomes...
October 5, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28827590/omalizumab-efficacy-in-cases-of-chronic-spontaneous-urticaria-is-not-explained-by-the-inhibition-of-sera-activity-in-effector-cells
#13
Eva Serrano-Candelas, Rubén Martínez-Aranguren, Olga Vega, Gabriel Gastaminza, Joan Bartra, Maria Teresa Audicana, Jorge M Núñez-Córdoba, Jaime Algorta, Antonio Valero, Margarita Martin, Marta Ferrer
Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involvement is not clear, suggesting the involvement of additional mechanisms of action. In this study, we sought to investigate the ability of OmAb to inhibit mast cell and basophil degranulation induced by sera from CSU patients...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810893/subcutaneous-emphysema-of-the-leg-after-hardware-removal-and-bone-allografting-for-infected-non-union-of-the-distal-femur
#14
Vincenzo Denaro, Umile Giuseppe Longo, Giuseppe Salvatore, Vincenzo Candela, Nicola Maffulli
BACKGROUND: Infected non-unions of the supracondylar region of the femur are uncommon. Even though hardware removal is a common procedure, it may lead to complications, including neurovascular injury, refracture, worsening pain or recurrence of deformity. CASE PRESENTATION: We report on a male who developed subcutaneous emphysema of the leg after hardware removal and bone allografting for an infected non-union of the distal femur. He was managed by debridement of the surgical wound, antibiotic therapy, multiple fasciotomies, and application of a VAC (vacuum-assisted closure) system...
August 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28806487/gut-microbiome-response-to-short-term-dietary-interventions-in-reactive-hypoglycemia-subjects
#15
Sara Quercia, Silvia Turroni, Jessica Fiori, Matteo Soverini, Simone Rampelli, Elena Biagi, Andrea Castagnetti, Clarissa Consolandi, Marco Severgnini, Mario Pianesi, Francesco Fallucca, Paolo Pozzilli, Patrizia Brigidi, Marco Candela
BACKGROUND: Reactive hypoglycemia is a metabolic disorder that provokes severe hypoglycemic episodes after meals. Over recent years, the gut microbiota has been recognized as potential target for the control of metabolic diseases, and the possibility to correct gut microbiota dysbioses through diet, favouring the recovery of metabolic homeostasis, has been considered. METHODS: We investigate the impact of 2 short-term (3-day) nutritional interventions, based on the macrobiotic Ma-Pi 2 diet and a control Mediterranean diet, on the structure and functionality of the gut microbiota in 12 patients affected by reactive hypoglycemia...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28798978/shoulder-pain-due-to-cervical-radiculopathy-an-underestimated-long-term-complication-of-herpes-zoster-virus-reactivation
#16
Stefano Gumina, Vittorio Candela, Daniele Passaretti, Ciro Villani
PURPOSE: To evaluate if herpes zoster virus (HZV) reactivation may be considered in the aetiology of cervical radiculopathy. METHODS: The study group was composed of 110 patients (52 M-58F;mean age ± SD:46.5 ± 6.12; range:40-73) with a clinical diagnosis of cervical radiculopathy. Patients with signs of chronic damage on neurophysiological studies were submitted to an X-ray and to an MRI of the cervical spine in order to clarify the cause of the cervical radiculopathy and were investigated for a possible reactivation of HZV; HZV reactivation was considered as "recent" or "antique" if it occurs within or after 24 months from the onset of symptoms, respectively...
August 10, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28789568/temporal-trends-in-the-use-of-antiplatelet-therapy-in-patients-with-acute-coronary-syndromes
#17
María Asunción Esteve-Pastor, Juan Miguel Ruíz-Nodar, Esteban Orenes-Piñero, José Miguel Rivera-Caravaca, Miriam Quintana-Giner, Andrea Véliz-Martínez, Antonio Tello-Montoliu, Vicente PerniasEscrig, Miriam Sandín Rollán, Nuria Vicente-Ibarra, Manuel Jesús MacíasVillanego, Elena Candela Sánchez, Luna Carrillo Alemán, Teresa Lozano, Mariano Valdés, Francisco Marín
BACKGROUND: Current clinical guidelines of acute coronary syndromes (ACS) recommend the use of potent antiplatelet therapy, prasugrel or ticagrelor, because both drugs consistently reduce cardiovascular events. PURPOSE: The aim of this study was to examine temporal changes in the use of optimal antiplatelet therapy in patients with ACS. METHODS: A total of 1717 consecutive patients admitted for ACS in 3 tertiary hospitals from February 2014 to December 2015 were enrolled...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28783066/utility-of-milk-coagulant-enzyme-of-moringa-oleifera-seed-in-cheese-production-from-soy-and-skim-milks
#18
María Alejandra Sánchez-Muñoz, Mónica Andrea Valdez-Solana, Claudia Avitia-Domínguez, Patricia Ramírez-Baca, María Guadalupe Candelas-Cadillo, Miguel Aguilera-Ortíz, Jorge Armando Meza-Velázquez, Alfredo Téllez-Valencia, Erick Sierra-Campos
In this study, the potential use of Moringa oleifera as a clotting agent of different types of milk (whole, skim, and soy milk) was investigated. M. oleifera seed extract showed high milk-clotting activity followed by flower extract. Specific clotting activity of seed extract was 200 times higher than that of flower extract. Seed extract is composed by four main protein bands (43.6, 32.2, 19.4, and 16.3 kDa). Caseinolytic activity assessed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and tyrosine quantification, showed a high extent of casein degradation using M...
August 5, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28768782/anterior-cruciate-ligament-reconstruction-in-skeletally-immature-patients-a-systematic-review
#19
REVIEW
U G Longo, M Ciuffreda, C Casciaro, N Mannering, V Candela, G Salvatore, V Denaro
AIMS: Different methods of anterior cruciate ligament (ACL) reconstruction have been described for skeletally immature patients before closure of the growth plates. However, the outcome and complications following this treatment remain unclear. The aim of this systematic review was to analyse the outcome and complications of different techniques which may be used for reconstruction of the ACL in these patients. MATERIALS AND METHODS: We performed a systematic review of the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
August 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28767441/socioeconomic-deprivation-worsens-the-outcomes-of-italian-women-with-hormone-receptor-positive-breast-cancer-and-decreases-the-possibility-of-receiving-standard-care
#20
Francesca Di Salvo, Nicola Caranci, Teresa Spadea, Nicolas Zengarini, Pamela Minicozzi, Hade Amash, Mario Fusco, Fabrizio Stracci, Fabio Falcini, Claudia Cirilli, Giuseppina Candela, Rosanna Cusimano, Rosario Tumino, Milena Sant, For The Socioeconomic Inequalities And Oncological Outcomes Italian Working Group
BACKGROUND: Socioeconomic factors influence access to cancer care and survival. This study investigated the role of socioeconomic status on the risk of breast cancer recurrence and on the delivery of appropriate cancer care (sentinel lymph node biopsy and breast-conserving surgery plus radiotherapy), by patients' age and hormone receptor status. METHODS: 3,462 breast cancer cases diagnosed in 2003-2005 were selected from 7 Italian cancer registries and assigned to a socioeconomic tertile on the basis of the deprivation index of their census tract...
July 22, 2017: Oncotarget
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