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https://www.readbyqxmd.com/read/28101899/recommendations-for-the-use-of-sensor-augmented-pumps-with-predictive-low-glucose-suspend-features-in-children-the-importance-of-education
#1
REVIEW
Andrea E Scaramuzza, Claudia Arnaldi, Valentino Cherubini, Elvira Piccinno, Ivana Rabbone, Sonia Toni, Stefano Tumini, Gilberto Candela, Paola Cipriano, Lucia Ferrito, Lorenzo Lenzi, Davide Tinti, Ohad Cohen, Fortunato Lombardo
Sensor-augmented pumps, which consist of a pump and a continuous glucose monitoring system, offer considerable therapeutic opportunities, despite requiring close attention in the early phase of their use. The aim of this paper is to provide recommendations on the use of a predictive low glucose management (PLGM) system (Minimed 640G™, Medtronic, Northridge, CA, USA) in adolescents with type 1 diabetes either at the start of therapy or during follow-up. Sound clinical recommendations on PLGM are of increasing importance since several recent papers have reported significant clinical improvements in patients with PLGM, especially in adults...
January 19, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28087495/comparative-analysis-of-variation-and-selection-in-the-hcv-genome
#2
Juan Ángel Patiño-Galindo, Fernando González-Candelas
Genotype 1 of the hepatitis C virus (HCV) is the most prevalent of the variants of this virus. Its two main subtypes, HCV-1a and HCV-1b, are associated to differences in epidemic features and risk groups, despite sharing similar features in most biological properties. We have analyzed the impact of positive selection on the evolution of these variants using complete genome coding regions, and compared the levels of genetic variability and the distribution of positively selected sites. We have also compared the distributions of positively selected and conserved sites considering different factors such as RNA secondary structure, the presence of different epitopes (antibody, CD4 and CD8), and secondary protein structure...
January 10, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28054826/experience-with-fampridine-in-clinical-practice-analysis-of-a-possible-marker-of-clinical-response
#3
Miriam Álvarez Payero, Candelas Valeiras Muñoz, Susana Lion Vázquez, Guadalupe Piñeiro Corrales, Delicias Muñoz García, Luciana Midaglia
PURPOSE OF THE STUDY: Approximately 85% of patients with multiple sclerosis experience reduced mobility, which negatively affects quality of life. Fampridine is the first symptomatic treatment aimed at improving gait. We analyzed effectiveness and tolerance in clinical practice. We also sought a prevalent gait pattern in responders as a potential clinical response marker. MATERIAL AND METHODS: 6-month prospective study of fampridine in patients with multiple sclerosis...
January 5, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28054822/episodic-future-thinking-following-vmpfc-damage-impaired-event-construction-maintenance-or-narration
#4
Elena Bertossi, Vanessa Candela, Flavia De Luca, Elisa Ciaramelli
OBJECTIVE: Functional neuroimaging and lesion studies show that the ventromedial prefrontal cortex (vmPFC) is implicated in episodic future thinking (EFT), yet its role remains unclear. In this study, we sought to (a) confirm recent findings of impaired EFT in patients with lesions to the vmPFC (vmPFC patients) using a new task, and (b) investigate the influence of nonepisodic mechanisms, namely, narrative construction and working memory maintenance, on vmPFC patients' EFT performance...
January 5, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28049008/the-gut-microbiota-of-centenarians-signatures-of-longevity-in-the-gut-microbiota-profile
#5
REVIEW
Biagi Elena, Simone Rampelli, Silvia Turroni, Sara Quercia, Marco Candela, Patrizia Brigidi
The changing physiology and lifestyle of elderly people affect the gut microbiota composition, the changes of which can, in turn, affect the health maintenance of the ageing host. In a co-evolutionary vision of the relationship between gut microbiota and ageing as an adaptive process of the human superorganism, long-living individuals who get to "successfully" age might be the ones whose microbiota manages to continuously re-establish a mutualistic relationship with the host, adapting to the progressive endogenous and environmental changes...
December 31, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28048013/su-f-t-63-dosimetric-relevance-of-the-valencia-and-leipzig-hdr-applicators-plastic-cap
#6
D Granero, C Candela-Juan, J Vijande, F Ballester, J Perez-Calatayud, D Jacob, F Mourtada
PURPOSE: Utilization of HDR brachytherapy treatment of skin lesions using collimated applicators, such as the Valencia or Leipzig is increasing. These applicators are made of cup-shaped tungsten material in order to focalize the radiation into the lesion and to protect nearby tissues. These applicators have an attachable plastic cap that removes secondary electrons generated in the applicator and flattens the treatment surface. The purpose of this study is to examine the dosimetric impact of this cap, and the effect if the cap is not placed during the HDR fraction delivery...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28008672/the-angulata7-gene-encodes-a-dnaj-like-zinc-finger-domain-protein-involved-in-chloroplast-function-and-leaf-development-in-arabidopsis
#7
Tamara Muñoz-Nortes, José Manuel Pérez-Pérez, María Rosa Ponce, Héctor Candela, José Luis Micol
The characterization of mutants with altered leaf shape and pigmentation has previously allowed the identification of nuclear genes that encode plastid-localized proteins that perform essential functions in leaf growth and development. A large-scale screen previously allowed us to isolate ethyl methanesulfonate-induced mutants with small rosettes and pale green leaves with prominent marginal teeth, which were assigned to a phenotypic class that we dubbed Angulata. The molecular characterization of the twelve genes assigned to this phenotypic class should help us to advance our understanding of the still poorly understood relationship between chloroplast biogenesis and leaf morphogenesis...
December 23, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28000484/nutrici%C3%A3-n-parenteral-domiciliaria-en-espa%C3%A3-a-durante-2015-informe-del-grupo-de-nutrici%C3%A3-n-artificial-domiciliaria-y-ambulatoria-nadya
#8
Carmina Wanden-Berghe Lozano, Cristina Campos Martín, Cristina Cuerda Compes, Carmen Gómez Candela, Rosa Burgos Peláez, José Manuel Moreno Villares, José Luis Pereira Cunill, Antonio Pérez de la Cruz, Nuria Virgili Casas, Ceferino Martinez Faedo, Julia Álvarez Hernández, Carmen Garde Orbaiz, Mª Ángeles Penacho Lázaro, Eva Ángeles Sánchez Martos, Alejandro Sanz Paris, Montserrat Gonzalo Marín, Ana Zugasti Murillo, Pilar Matía Martín, Tomás Martín Folgueras, Fátima Carabaña Pérez, Patricia Díaz Guardiola, Cristina Tejera Pérez, Daniel De Luis Román, Luis Miguel Luengo Pérez, Nieves Santacruz Carmona, Antxón Apezetxea Celaya, Miguel Ángel Ponce González, Juan Ramón Urgeles Planella, Lucía Laborda González, Miguel Ángel Martinez Olmos, Olga Sánchez-Vilar Burdiel, Clara Joaquín Ortiz, Cecilia Martínez Costa, José Pablo Suárez Llanos, Alicia Calleja Fernández, Pere Leyes García, Mª Carmen Gil Martinez, Silvia Mauri Roca, Maria Victoria García Zafra, María José Carrera Santaliestra, Grupo Nadya-Senpe
Objetivo: Comunicar los datos del registro de Nutrición Parenteral Domiciliaria (NPD) del grupo de trabajo NADYA-SENPE del años 2015.Material y métodos: Recopilación de los datos de NPD del registro "on-line" del grupo de Nutrición Artificial Domiciliaria y Ambulatoria (NADYA) desde el 1 de enero de 2015 al 31 de diciembre de 2015.Resultados: Se registraron 236 pacientes, con 243 episodios de NPD procedentes de 40 hospitales. Lo que representa una tasa de 5,08 pacientes/millón de habitantes/ año 2015...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27992498/lack-of-impact-of-posidonia-oceanica-leaf-nutrient-enrichment-on-sarpa-salpa-herbivory-additional-evidence-for-the-generalist-consumer-behavior-of-this-cornerstone-mediterranean-herbivore
#9
Candela Marco-Méndez, Caitlin Wessel, Whitney Scheffel, Luis Ferrero-Vicente, Yolanda Fernández-Torquemada, Just Cebrián, Kenneth L Heck, Jose Luis Sánchez-Lizaso
The fish Sarpa salpa (L.) is one of the main macroherbivores in the western Mediterranean. Through direct and indirect mechanisms, this herbivore can exert significant control on the structure and functional dynamics of seagrass beds and macroalgae. Past research has suggested nutritional quality of their diet influences S. salpa herbivory, with the fish feeding more intensively and exerting greater top down control on macrophytes with higher internal nutrient contents. However recent findings have questioned this notion and shown that herbivores do not preferentially feed on macrophytes with higher nutrient contents, but rather feed on a wide variety of them with no apparent selectivity...
2016: PloS One
https://www.readbyqxmd.com/read/27982309/experiences-and-coping-with-the-altered-body-image-in-digestive-stoma-patients
#10
César Hueso-Montoro, Candela Bonill-de-Las-Nieves, Miriam Celdrán-Mañas, Sandra Milena Hernández-Zambrano, Manuel Amezcua-Martínez, José Miguel Morales-Asencio
Objective: to describe the coping of stoma patients with the news about the ostomy, as well as to analyze the meaning and the experience of their new bodily reality. Method: qualitative phenomenological study undertaken through semistructured interviews with 21 stoma patients. The analysis was based on the constant comparison of the data, the progressive incorporation of subjects and triangulation among researchers and stomal therapy nurses. The software Atlas.ti was used...
December 8, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27979416/the-effect-of-smoking-on-clinical-and-structural-damage-in-patients-with-axial-spondyloarthritis-a-systematic-literature-review
#11
REVIEW
Virginia Villaverde-García, Tatiana Cobo-Ibáñez, Gloria Candelas-Rodríguez, Daniel Seoane-Mato, Petra Díaz Del Campo-Fontecha, Mercedes Guerra, Santiago Muñoz-Fernández, Juan D Cañete
OBJECTIVES: To evaluate the association between smoking and clinical parameters and structural damage in axial spondyloarthritis (axSpA). METHODS: We systematically searched MEDLINE, EMBASE and Cochrane Library till November 2015. We selected articles that analysed the smoking impact on disease activity, functional status, structural damage, physical mobility and life quality. Independent extraction of articles by 2 authors using predefined data fields was performed...
November 16, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27957717/emotional-understanding-reactivity-and-regulation-in-young-children-with-adhd-symptoms
#12
Claudia Lugo-Candelas, Chaia Flegenheimer, Jennifer M McDermott, Elizabeth Harvey
The goal of the present study was to examine whether young children with attention-deficit/hyperactivity disorder (ADHD) symptoms experience difficulties with emotional understanding, reactivity, and regulation. Participants were 64 children, 4 to 7 years of age (43 boys, 20 girls), 29 with ADHD symptoms and 34 typically developing children. Children completed an emotion matching task and parents reported on child lability and emotional regulation. Children also completed a frustrating computer task. Facial expressions of emotions were coded and children self reported affect during the task...
December 12, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27939112/validity-and-reliability-of-the-spanish-language-version-of-the-self-administered-leeds-assessment-of-neuropathic-symptoms-and-signs-s-lanss-pain-scale
#13
I López-de-Uralde-Villanueva, A Gil-Martínez, P Candelas-Fernández, J de Andrés-Ares, H Beltrán-Alacreu, R La Touche
INTRODUCTION: The self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) scale is a tool designed to identify patients with pain with neuropathic features. OBJECTIVE: To assess the validity and reliability of the Spanish-language version of the S-LANSS scale. METHODS: Our study included a total of 182 patients with chronic pain to assess the convergent and discriminant validity of the S-LANSS; the sample was increased to 321 patients to evaluate construct validity and reliability...
December 8, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27934591/generation-of-a-human-induced-pluripotent-stem-cell-ipsc-line-from-a-bernard-soulier-syndrome-patient-with-the-mutation-p-asn45ser-in-the-gpix-gene
#14
Lourdes Lopez-Onieva, Candela Machuca, Mar Lamolda, Rosa Montes, Maria Luisa Lozano, Vicente Vicente, José Rivera, Verónica Ramos-Mejía, Pedro J Real
Bernard Soulier Syndrome (BSS) is an inherited rare platelet disorder characterized by mutations in the platelet glycoprotein complex GPIb-IX-V. We generated an induced pluripotent stem cell (iPSC) line from a BSS patient with a mutation p.Asn45Ser in the GPIX locus (BSS2-PBMC-iPS4F24). Peripheral blood mononuclear cells were reprogrammed using non-integrative viral transduction. Characterization of BSS2-PBMC-iPS4F24 included mutational analysis of GPIX locus, analysis of conventional pluripotency-associated factors at mRNA and protein level and in vitro and in vivo differentiation studies...
November 8, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27933383/the-burden-of-rotator-cuff-surgery-in-italy-a-nationwide-registry-study
#15
Umile Giuseppe Longo, Giuseppe Salvatore, Giacomo Rizzello, Alessandra Berton, Mauro Ciuffreda, Vincenzo Candela, Vincenzo Denaro
PURPOSE: This study aimed to estimate the yearly number of RC surgeries in Italy, a country with universal access to healthcare for its population, from 2001 to 2014, based on official information source as hospitalization records. A secondary aim was to explore geographical variation in equity in access to RC surgery between three macroregions of Italy (North, Center and South). A tertiary aim was to perform statistical projections of the number of RC procedure volumes and rates on the basis of data from 2001 to 2014...
December 8, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27928411/visual-impairment-due-to-lissencephaly
#16
V E Marqués-Fernández, H Sánchez-Tocino, M T Escudero-Caro, R Cancho-Candela, M García-Zamora
Lissencephaly is a rare disorder due to abnormal neural migration, causing neurological impairment and clinically characterised by mental retardation and epilepsy. Any disturbance of the visual pathway can cause loss of vision. The authors describe a case of a 6-year-old boy referred to the ophthalmologist presenting poor bilateral vision. This child had no other known medical conditions, and neurological examination was completely normal. Only when a magnetic resonance imaging was made that a lissencephaly-pachygyria with band heterotopia mostly occipital was noted...
October 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27920488/evalmsa-a-program-to-evaluate-multiple-sequence-alignments-and-detect-outliers
#17
Alvaro Chiner-Oms, Fernando González-Candelas
We present EvalMSA, a software tool for evaluating and detecting outliers in multiple sequence alignments (MSAs). This tool allows the identification of divergent sequences in MSAs by scoring the contribution of each row in the alignment to its quality using a sum-of-pair-based method and additional analyses. Our main goal is to provide users with objective data in order to take informed decisions about the relevance and/or pertinence of including/retaining a particular sequence in an MSA. EvalMSA is written in standard Perl and also uses some routines from the statistical language R...
2016: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/27918528/origin-of-modern-syphilis-and-emergence-of-a-pandemic-treponema-pallidum-cluster
#18
Natasha Arora, Verena J Schuenemann, Günter Jäger, Alexander Peltzer, Alexander Seitz, Alexander Herbig, Michal Strouhal, Linda Grillová, Leonor Sánchez-Busó, Denise Kühnert, Kirsten I Bos, Leyla Rivero Davis, Lenka Mikalová, Sylvia Bruisten, Peter Komericki, Patrick French, Paul R Grant, María A Pando, Lucía Gallo Vaulet, Marcelo Rodríguez Fermepin, Antonio Martinez, Arturo Centurion Lara, Lorenzo Giacani, Steven J Norris, David Šmajs, Philipp P Bosshard, Fernando González-Candelas, Kay Nieselt, Johannes Krause, Homayoun C Bagheri
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history(1). Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the second-line antibiotic azithromycin(3)...
December 5, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27902663/nursing-practices-and-policies-related-to-family-presence-during-resuscitation
#19
Kelly A Powers, Lori Candela
BACKGROUND: Despite its shown benefits, family presence during resuscitation (FPDR) is a controversial topic among critical care nurses and is not routinely implemented. OBJECTIVES: The objective of this study was to describe FPDR practices among critical care nurses, as well as the prevalence of FPDR policies and education. METHODS: The study used a descriptive survey design. Data were collected from a convenience sample of critical care nurses obtained at a national level...
January 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/27900705/sleep-quality-and-disturbances-in-patients-with-different-sized-rotator-cuff-tear
#20
S Gumina, V Candela, D Passaretti, T Venditto, L Mariani, G Giannicola
INTRODUCTION: The literature is unanimous in saying that shoulder pain, due to rotator cuff tear (RCT), may be mostly at night; to our knowledge, this statement is not supported by scientific evidence. Our aim was to investigate sleep quality and disturbances in patient with RCT and in a control group. MATERIALS AND METHODS: A case-control design study was used. We enrolled 324 consecutive patients (Group A) (156M-168F, mean age ± SD: 64.94 ± 6.97; range 47-74) who underwent arthroscopic rotator cuff repair...
December 2016: Musculoskeletal Surgery
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