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https://www.readbyqxmd.com/read/29685332/estimated-glomerular-filtration-rate-is-an-early-biomarker-of-cardiac-surgery-associated-acute-kidney-injury
#1
Ángel Candela-Toha, María Carmen Pardo, Teresa Pérez, Alfonso Muriel, Javier Zamora
BACKGROUND: and objective Acute kidney injury (AKI) diagnosis is still based on serum creatinine and diuresis. However, increases in creatinine are typically delayed 48h or longer after injury. Our aim was to determine the utility of routine postoperative renal function blood tests, to predict AKI one or 2days in advance in a cohort of cardiac surgery patients. PATIENTS AND METHODS: Using a prospective database, we selected a sample of patients who had undergone major cardiac surgery between January 2002 and December 2013...
April 20, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29680822/disparities-in-the-estimation-of-glomerular-filtration-rate-according-to-cockcroft-gault-modification-of-diet-in-renal-disease-4-and-chronic-kidney-disease-epidemiology-collaboration-equations-and-relation-with-outcomes-in-patients-with-acute-coronary-syndrome
#2
José Miguel Rivera-Caravaca, Juan Miguel Ruiz-Nodar, Antonio Tello-Montoliu, María Asunción Esteve-Pastor, Miriam Quintana-Giner, Andrea Véliz-Martínez, Esteban Orenes-Piñero, Ana Isabel Romero-Aniorte, Nuria Vicente-Ibarra, Vicente Pernias-Escrig, Luna Carrillo-Alemán, Elena Candela-Sánchez, Ignacio Hortelano, Beatriz Villamía, Miriam Sandín-Rollán, Laura Nuñez-Martínez, Mariano Valdés, Francisco Marín
BACKGROUND: A simple method to assess renal function is the estimated glomerular filtration rate, and it shows prognostic implications. However, it remains unknown which equation should be used in patients with acute coronary syndrome. We compared the ability and correlation of the Cockcroft-Gault, Modification of Diet in Renal Disease-4 (MDRD-4), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and their predictive performance for major adverse cardiovascular events, all-cause mortality, and major bleeding in a cohort of patients with acute coronary syndrome...
April 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29666111/decreasing-an-offloading-device-s-size-and-offsetting-its-imposed-limb-length-discrepancy-lead-to-improved-comfort-and-gait
#3
Ryan T Crews, Joseph Candela
OBJECTIVE: Patient adherence is a challenge in offloading diabetic foot ulcers (DFUs) with removable cast walkers (RCWs). The size and weight of an RCW, changes to gait, and imposed limb length discrepancies may all discourage adherence. This study sought to determine whether RCW size and provision of a contralateral limb lift affected users' comfort and gait. RESEARCH DESIGN AND METHODS: Twenty-five individuals at risk for DFUs completed several 20-m walking trials under five footwear conditions: bilateral standardized shoes, a knee-high RCW with shoe with or without an external shoe lift contralaterally, and an ankle-high RCW with shoe with or without an external shoe lift contralaterally...
April 17, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29659593/the-complexity-of-patients-hospitalized-in-internal-medicine-wards-evaluated-by-fadoi-complimed-score-s-a-hypothetical-approach
#4
Erminio Bonizzoni, Gualberto Gussoni, Giancarlo Agnelli, Raffaele Antonelli Incalzi, Moira Bonfanti, Franco Mastroianni, Marco Candela, Carlotta Franchi, Stefania Frasson, Antonio Greco, Micaela La Regina, Roberta Re, Giorgio Vescovo, Mauro Campanini
OBJECTIVES: The aim of this study is to develop a new predictive model to measure complexity of patients in medical wards. SETTING: 29 Internal Medicine departments in Italy. MATERIALS AND METHODS: The study cohort was made of 541 consecutive patients hospitalized for any cause, aged more than 40 years and with at least two chronic diseases. First, we applied a hierarchical cluster analysis and the principal component analysis (PCA) to a panel of questionnaires [comorbidity (Charlson, CIRS), clinical stability (MEWS), social frailty (Flugelman), cognitive dysfunction (SPSMQ), depression (5-item GDS), functional dependence (ADL, IADL, Barthel), risk of sore threats (Exton-Smith scale), nutrition (MNA), pain (NRPS), adherence to therapy (Morisky scale)], in order to select domains informative for the definition of complexity...
2018: PloS One
https://www.readbyqxmd.com/read/29622432/sirtuin-5-as-a-novel-target-to-blunt-blood-brain-barrier-damage-induced-by-cerebral-ischemia-reperfusion-injury
#5
Candela Diaz-Cañestro, Mario Merlini, Nicole R Bonetti, Luca Liberale, Patricia Wüst, Sylvie Briand-Schumacher, Jan Klohs, Sara Costantino, Melroy Miranda, Gabriele Schoedon-Geiser, Gerd A Kullak-Ublick, Alexander Akhmedov, Francesco Paneni, Jürg H Beer, Thomas F Lüscher, Giovanni G Camici
BACKGROUND: In acute ischemic stroke (AIS) patients, impaired blood-brain barrier (BBB) integrity is associated with hemorrhagic transformation and worsened outcome. Yet, the mechanisms underlying these relationships are poorly understood and consequently therapeutic strategies are lacking. This study sought to determine whether SIRT5 contributes to BBB damage following I/R brain injury. METHODS AND RESULTS: SIRT5 knockout (SIRT5-/- ) and wild type (WT) mice underwent transient middle cerebral artery (MCA) occlusion (tMCAO) followed by 48h of reperfusion...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29594176/scapular-dyskinesis-in-young-asymptomatic-elite-swimmers
#6
Jacopo Preziosi Standoli, Francesco Fratalocchi, Vittorio Candela, Tiziano Preziosi Standoli, Giuseppe Giannicola, Marco Bonifazi, Stefano Gumina
Background: Overhead athletes are at a greater risk of developing scapular dyskinesis (SD). Although swimming is considered an overhead sport, information regarding SD in these athletes is scarce. Purpose: To determine the prevalence of SD in young, asymptomatic elite swimmers. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 661 asymptomatic elite swimmers were enrolled in this study (344 male, 317 female; mean age, 15...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29582705/comparative-assessment-of-prophylactic-transfusions-of-platelet-concentrates-obtained-by-the-prp-or-buffy-coat-methods-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#7
Hermógenes Fernández-Muñoz, Eva M Plaza, José Miguel Rivera-Caravaca, María José Candela, Marta Romera, Felipe De Arriba, María L Lozano, Vicente Vicente, Inmaculada Heras, Cristina Castilla-Llorente, José Rivera
OBJECTIVES: Whole blood-derived platelet concentrates can be obtained by the platelet-rich plasma (PRP-PCs) or the buffy-coat (BC-PCs) method. Few studies have shown that BC-PCs display lower in vitro platelet activation, but scarce information exists regarding transfusion efficacy. We have performed a retrospective study assessing platelet transfusion in patients undergoing allogeneic hematopoietic cell transplantation (AHCT) in our clinic, before and after the implementation of BC-PCs...
March 27, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29580835/implications-of-the-mediterranean-diet-and-physical-exercise-on-the-lipid-profile-of-metabolically-healthy-obese-women-as-measured-by-nuclear-magnetic-resonance-spectroscopy-1-h-nmr
#8
Enrique Rodriguez-Garcia, Josefina Ruiz-Nava, Sonia Santamaria-Fernandez, Jose Carlos Fernandez-Garcia, Antonio Vargas Candela, Raquel Yahyaoui, Francisco J Tinahones, M Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
OBJECTIVE: There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects' lipid profiles. Our objective was to characterize lipoprotein size, particle and subclass concentration using1 H NMR in MHO women after two years of weight loss with a hypocaloric Mediterranean diet and physical exercise. METHODS: 115 non-diabetic women (aged 35-55 years) with a body mass index (BMI) of 30-40 kg/m2 and ≤1 of the following criteria: blood pressure ≥135/85 mmHg, fasting plasma glucose ≥100 mg/dL, HDL cholesterol ≤50 mg/dL and triglycerides ≥150 mg/dL were included...
March 23, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29573758/age-related-and-photoperiodic-variation-of-the-daz-gene-family-in-the-testis-of-the-syrian-hamster-mesocricetus-auratus
#9
Candela Rocío González, Luciana Moverer, Ricardo Saúl Calandra, Silvia Inés González-Calvar, Alfredo Daniel Vitullo
The Deleted in AZoospermia (DAZ) gene family regulates the development, maturation and maintenance of germ cells and spermatogenesis in mammals. The DAZ family consists of two autosomal genes, Boule and Dazl (Daz-like), and the Daz gene on chromosome Y. The aim of this study was to analyze the localization of DAZL and BOULE during testicular ontogeny of the seasonal-breeding Syrian hamster, Mesocricetus auratus. We also evaluated the testicular expression of DAZ family genes under short- or long-photoperiod conditions...
March 25, 2018: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29565629/-consensus-document-about-the-nutritional-evaluation-and-management-of-eating-disorders-bulimia-nervosa-binge-eating-disorder-and-others
#10
Carmen Gómez Candela, Samara Palma Milla, Alberto Miján-de-la-Torre, Pilar Rodríguez Ortega, Pilar Matía Martín, Viviana Loria Cohen, Rocío Campos Del Portillo, M ª Nuria Virgili Casas, Miguel Á Martínez Olmos, M ª Teresa Mories Álvarez, M ª José Castro Alija, Ángela Martín-Palmero
Bulimia nervosa and binge eating disorder are unique nosological entities. Both show a large variability related to its presentation and severity which involves different therapeutic approaches and the need to individualize the treatment, thus it is indispensable a multidisciplinary approach. Patients with bulimia nervosa may suffer from malnutrition and deficiency states or even excess weight, while in binge eating disorders, it is common overweight or obesity, which determine other comorbidities. Many of the symptoms and complications are associated with compensatory behaviors...
March 7, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29565628/-consensus-document-about-the-nutritional-evaluation-and-management-of-eating-disorders-anorexia-nervosa
#11
Carmen Gómez-Candela, Samara Palma Milla, Alberto Miján-de-la-Torre, Pilar Rodríguez Ortega, Viviana Loria Kohen, Rocío Campos Del Portillo, Ángela Martín-Palmero, M ª Nuria Virgili Casas, Miguel Á Martínez Olmos, M ª Teresa Mories Álvarez, M ª José Castro Alija, Ángela Martín-Palmero
Anorexia nervosa is the most common psychiatric disease among young women and it is assumed to be of multifactorial origin. Diagnostic criteria have recently been modified; therefore amenorrhea has ceased to be a part of them. This disease shows a large variability in its presentation and severity which conditions different therapeutic approaches and the need to individualize the treatment, thus it is indispensable a multidisciplinary approach. The goals are to restore nutritional status (through an individualized diet plan based on a healthy consumption pattern), treat complications and comorbidities, nutritional education (based on healthy eating and nutritional patterns), correction of compensatory behaviors and relapse prevention...
March 7, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29565627/-consensus-document-about-the-nutritional-evaluation-and-management-of-eating-disorders-anorexia-nervosa-bulimia-nervosa-binge-eating-disorder-and-others
#12
Carmen Gómez Candela, Samara Palma Milla, Alberto Miján-de-la-Torre, Pilar Rodríguez Ortega, Viviana Loria Kohen, Rocío Campos Del Portillo, M ª Nuria Virgili Casas, Miguel Á Martínez Olmos, M ª Teresa Mories Álvarez, M ª José Castro Alija, Ángela Martín-Palmero
Eating disorders (ED) are characterized by persistent changes in eating habits that negatively affect a person's health and psychosocial abilities. They are considered psychiatric disorders, highly variable in their presentation and severity, with a huge impact on nutrition, which conditions various therapeutic approaches within a key multidisciplinary context. A group of experts in nutrition, we decided to set up a task force adscribed to the "Sociedad Española de Nutrición Parenteral y Enteral" (SENPE), which has stated as one of its goals the development of a consensus document to generate a protocol based on the best scientific evidence and professional experience available in order to improve health care in this field...
March 7, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29534508/functional-characterization-of-the-alb1-orthologue-gene-in-the-ochratoxigenic-fungus-aspergillus-carbonarius-ac49-strain
#13
Donato Gerin, Luis González-Candelas, Ana-Rosa Ballester, Stefania Pollastro, Rita Milvia De Miccolis Angelini, Francesco Faretra
Aspergillus carbonarius, belonging to the group Nigri , is the main species responsible for contamination by ochratoxin A (OTA) in grapes and derivative products. OTA can accumulate in the mycelium and in black conidia of the fungus and released into the matrix. Here, we have deleted in A. carbonarius the alb1 orthologue gene of A. fumigatus , involved in melanin biosynthesis. Three A. carbonarius Δ alb1 mutants were characterized for morphologic traits and OTA production on different media and temperatures...
March 12, 2018: Toxins
https://www.readbyqxmd.com/read/29501057/impact-of-the-implementation-of-vasoactive-drug-protocols-on-costs-in-the-treatment-of-critically-ill-patients
#14
Isabel Cuesta-López, Marina Sánchez-Cuervo, Ángel Candela-Toha, Juana Benedí-González, Teresa Bermejo-Vicedo
OBJECTIVE: To evaluate the efficiency of the protocolization and centralization of  the preparation of intravenous vasoactive drug mixtures in the treatment of  critically ill patients. METHOD: A prospective interventional study (July 2012-December 2014) was  conducted to measure the impact of different vasoactive drug protocols on costs  in the treatment of critically ill patients. The economic impact was measured by  comparing the direct costs (fixed and variable) of the preparation of intravenous  vasoactive drug mixtures in the Pharmacy Department with their traditional  preparation in hospital care units...
March 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29498356/calibration-of-a-thermoluminescent-dosimeter-worn-over-lead-aprons-in-fluoroscopy-guided-procedures
#15
Alfonso Quintero-Quintero, Galo Patiño Camargo, Ángela Soriano Cruz, Juan Diego Palma Copete, Jorge Vilar Palop, Maria Del Carmen Pujades, Nieves Llorca Domaica, Facundo Ballester, Javier Vijande, Cristian Candela-Juan
Fluoroscopy guided interventional procedures provide remarkable benefits to patients. However, the medical staff working near the scattered radiation field may be exposed to high cumulative equivalent doses, thus requiring shielding devices such as lead aprons and thyroid collars. In this situation, it remains an acceptable practice to derive equivalent doses to the eye lenses or other unprotected soft tissues with a dosimeter placed above these protective devices. Nevertheless, the radiation backscattered by the lead shield differs from that generated during dosimeter calibration with a water phantom...
March 2, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29491848/surfaceome-and-proteosurfaceome-in-parietal-monoderm-bacteria-focus-on-protein-cell-surface-display
#16
REVIEW
Mickaël Desvaux, Thomas Candela, Pascale Serror
The cell envelope of parietal monoderm bacteria (archetypal Gram-positive bacteria) is formed of a cytoplasmic membrane (CM) and a cell wall (CW). While the CM is composed of phospholipids, the CW is composed at least of peptidoglycan (PG) covalently linked to other biopolymers, such as teichoic acids, polysaccharides, and/or polyglutamate. Considering the CW is a porous structure with low selective permeability contrary to the CM, the bacterial cell surface hugs the molecular figure of the CW components as a well of the external side of the CM...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29491462/gene-expression-models-based-on-a-reference-laboratory-strain-are-poor-predictors-of-mycobacterium-tuberculosis-complex-transcriptional-diversity
#17
Álvaro Chiner-Oms, Fernando González-Candelas, Iñaki Comas
Every year, species of the Mycobacterium tuberculosis complex (MTBC) kill more people than any other infectious disease caused by a single agent. As a consequence of its global distribution and parallel evolution with the human host the bacteria is not genetically homogeneous. The observed genetic heterogeneity has relevance at different phenotypic levels, from gene expression to epidemiological dynamics. However, current systems biology datasets have focused on the laboratory reference strain H37Rv. By using large expression datasets testing the role of almost two hundred transcription factors, we have constructed computational models to grab the expression dynamics of Mycobacterium tuberculosis H37Rv genes...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29475577/lumbar-disc-herniation-surgery-with-microdiscectomy-plus-interspinous-stabilization-good-clinical-results-but-failure-to-lower-the-incidence-of-re-operation
#18
REVIEW
Manuel Segura-Trepichio, Antonio Martin-Benlloch, Jose Manuel Montoza-Nuñez, David Candela-Zaplana, Andreu Nolasco
BACKGROUND: Discectomy is sometimes associated with recurrence of disc herniation and pain after surgery. The evidence to use an interspinous dynamic stabilization system (IDSS) in association with disc excision to prevent pain and re-operation, remains controversial. METHODS: Patients (age 18-50 years) presenting with lumbago/sciatica (ICD-10-CM M54.3, M54.4) due to voluminous lumbar disc herniation were eligible for participation. Patients underwent microdiscectomy plus IDSS...
February 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29470411/stroke-like-episodes-and-cerebellar-syndrome-in-phosphomannomutase-deficiency-pmm2-cdg-evidence-for-hypoglycosylation-driven-channelopathy
#19
Mercè Izquierdo-Serra, Antonio F Martínez-Monseny, Laura López, Julia Carrillo-García, Albert Edo, Juan Darío Ortigoza-Escobar, Óscar García, Ramón Cancho-Candela, M Llanos Carrasco-Marina, Luis G Gutiérrez-Solana, Daniel Cuadras, Jordi Muchart, Raquel Montero, Rafael Artuch, Celia Pérez-Cerdá, Belén Pérez, Belén Pérez-Dueñas, Alfons Macaya, José M Fernández-Fernández, Mercedes Serrano
Stroke-like episodes (SLE) occur in phosphomannomutase deficiency (PMM2-CDG), and may complicate the course of channelopathies related to Familial Hemiplegic Migraine (FHM) caused by mutations in CACNA1A (encoding CaV 2.1 channel). The underlying pathomechanisms are unknown. We analyze clinical variables to detect risk factors for SLE in a series of 43 PMM2-CDG patients. We explore the hypothesis of abnormal CaV 2.1 function due to aberrant N -glycosylation as a potential novel pathomechanism of SLE and ataxia in PMM2-CDG by using whole-cell patch-clamp, N -glycosylation blockade and mutagenesis...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29464922/reliability-and-validity-of-a-questionnaire-for-physical-activity-assessment-in-south-american-children-and-adolescents-the-saycare-study
#20
Marcus Vinícius Nascimento-Ferreira, Augusto César Ferreira De Moraes, Paulo Vinícius Toazza-Oliveira, Claudia L M Forjaz, Juan Carlos Aristizabal, Alba M Santaliesra-Pasías, Candela Lepera, Walter Viana Nascimento-Junior, Estela Skapino, Carlos Alberto Delgado, Luis Alberto Moreno, Heráclito Barbosa Carvalho
OBJECTIVE: The objective of this article is to test the reliability and validity of the new and innovative physical activity (PA) questionnaire. METHODS: Subsamples from the South American Youth/Child Cardiovascular and Environment Study (SAYCARE) study were included to examine its reliability (children: n = 161; adolescents: n = 177) and validity (children: n = 82; adolescents: n = 60). The questionnaire consists of three dimensions of PA (leisure, active commuting, and school) performed during the last week...
March 2018: Obesity
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