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https://www.readbyqxmd.com/read/29917335/assessment-and-management-of-older-people-with-venous-leg-ulcers
#1
Marie Todd
A venous leg ulcer (VLU) is defined as the loss of skin below the knee on the leg or foot in the presence of venous disease, which takes more than two weeks to heal. The prevalence of VLUs is increasing, especially in older people, which will increase the demand for nursing care. Development of a lower leg ulcer should trigger immediate assessment of risk factors for chronic venous disease followed by action to identify the cause and initiate treatment, which should prevent progression to more complex and chronic problems...
June 19, 2018: Nursing Older People
https://www.readbyqxmd.com/read/29917207/impact-of-patients-nutritional-status-on-major-surgery-outcome
#2
E V Mignini, E Scarpellini, E Rinninella, E Lattanzi, M V Valeri, N Clementi, L Abenavoli, A Gasbarrini, C Rasetti, P Santori
OBJECTIVE: Surgery is a major stress factor that activates several inflammatory and catabolic pathways in man. An appropriate nutritional status allows the body to react properly to this stressor and recover in a faster and more efficient manner. On the other hand, malnutrition is related to a worse surgery outcome and to a higher prevalence of comorbidities and mortality. The aims of this study were to evaluate the nutritional status of patients undergoing major surgery and investigate the potential correlation between malnutrition and surgical outcomes...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917206/up-regulation-of-microrna-503-by-high-glucose-reduces-the-migration-and-proliferation-but-promotes-the-apoptosis-of-human-umbilical-vein-endothelial-cells-by-inhibiting-the-expression-of-insulin-like-growth-factor-1-receptor
#3
L-J Hou, J-J Han, Y Liu
OBJECTIVE: The present study is aimed to investigate the regulatory effect of microRNA (miRNA or miR)-503 on endothelial functions, as well as the mechanism by which high glucose leads to injury of endothelial cells. MATERIALS AND METHODS: When reaching 80% confluency, human umbilical vein endothelial cells (HUVECs) were subjected to non-serum synchronization for 12 h, and medium of cells in high-glucose (HG) group was replaced by normal medium supplemented with 25 mmol/L D-glucose...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916991/risk-factors-for-early-reoperation-after-operative-treatment-of-acetabular-fractures
#4
Anthony Ding, Robert V OʼToole, Renan Castillo, Brad Reahl, Ryan Montalvo, Jason W Nascone, Marcus F Sciadini, Anthony R Carlini, Theodore T Manson
OBJECTIVES: To identify the risk factors for early reoperation after operative fixation of acetabular fractures. DESIGN: Retrospective evaluation. SETTING: Level I Trauma Center. PATIENTS: Seven hundred ninety-one patients with displaced acetabular fractures treated with open reduction and internal fixation (ORIF) from 2006 to 2015. Average follow-up was 52 weeks. MAIN OUTCOME MEASURES: Early reoperation after acetabular ORIF, defined as secondary procedure for infection or revision within 3 years of initial operation...
July 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29916970/optimal-timing-of-alveolar-cleft-bone-grafting-for-maxillary-clefts-in-the-cleft-palate-population
#5
Arminder S Kaura, Dhivya R Srinivasa, Steven J Kasten
PURPOSE: Timing of bone grafting for maxillary alveolar clefts is not standardized. Secondary bone grafting is often performed; however, consensus does not exist regarding use of chronologic versus dental age to guide treatment. Several authors suggest an early chronologic age is associated with greater success. Available literature was systematically reviewed for evidence for optimal timing for grafting maxillary alveolar clefts. METHODS: PubMed, MEDLINE, and Cochrane Central Registrar of Controlled Trials databases were queried for manuscripts pertaining to maxillary alveolar cleft bone grafting...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916933/a-locked-intraosseous-nail-for-transverse-patellar-fractures-a-biomechanical-comparison-with-tension-band-wiring-through-cannulated-screws
#6
Michael Nienhaus, Ivan Zderic, Dieter Wahl, Boyko Gueorguiev, Pol Maria Rommens
BACKGROUND: Displaced transverse patellar fractures require open reduction and internal fixation. State-of-the-art stabilization techniques are tension band wiring (TBW) using Kirschner wires or cannulated screws. These techniques are associated with high rates of secondary fracture displacement, implant migration, implant prominence, wound-healing disturbances, and the need for implant removal. Recently, a locked intraosseous patellar nail prototype was developed. The aim of the present study was to investigate the biomechanical performance of this nail compared with TBW using cannulated screws...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916897/lncrna-malat1-promotes-migration-and-invasion-of-non-small-cell-lung-cancer-by-targeting-mir-206-and-activating-akt-mtor-signaling
#7
Yi Tang, GaoMing Xiao, YueJun Chen, Yu Deng
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in lung cancer. The aim of this study is to unravel the underlying mechanisms of lncRNA MALAT1 in non-small-cell lung cancer (NSCLC). A cohort of 36 NSCLC tumor tissues and adjacent normal tissues was collected postoperatively from patients with NSCLC. qRT-PCR was performed to detect the expression of MALAT1 in both NSCLC tissues and cell lines. Cell migration and invasion were monitored by wound healing assay and transwell invasion assay...
June 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29916889/a-new-technique-in-management-of-depressed-posttracheostomy-scars
#8
Sevgi Kurt Yazar, Erkan Yüce, Merdan Serin, Memet Yazar, Zeliha Gül, Fatih Irmak, Serhat Selami Şirvan
BACKGROUND: The goals of tracheostomy scar revision are filling of the depressed area, providing easy sliding of skin over the trachea. There are various techniques described to correct this situation. In this article, a modification of split sternocleidomastoid (SCM) muscle flap used in the correction of posttracheostomy defects is described. METHODS: Thirteen patients who had depressed scars after tracheostomy are included in this study. The mean patient age was 44 years (range, 27-56 years)...
June 19, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29916424/footwear-in-the-causation-and-prevention-of-foot-ulcers-in-diabetes-mellitus
#9
Ramaswamy Premkumar, Pitchaimuthu Rajan, Jeeva Rima, Joseph Richard
Background.: Inappropriate footwear may be a major cause of foot ulceration among patients with diabetic neuropathy in India. No study has specifically examined the types of footwear or its components in patients with diabetes mellitus and their role in causing foot ulcers. We analysed the role of commonly used footwear in India in inducing first foot ulcers (FFU) in people with diabetes. Methods.: Of 4800 patients with diabetes attending our centre over 1 year, 301 had FFU from different causes...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916226/the-effect-of-low-molecular-weight-heparin-on-salvaging-the-zone-of-stasis-in-an-experimental-burn-model
#10
Muhammet Uraloğlu, Murat Livaoğlu, Özgür Agdoğan, Şafak Ersöz, Naci Karaçal
Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis. Materials and methods: Adult female rats were randomly divided two groups: the LMWH group (n = 8) rats received subcutaneous LMWH injections, while the saline group (n = 8) rats were injected with the same volume of saline solution by the same route...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29916223/ankaferd-blood-stopper-with-antibiofilm-potential-successfully-inhibits-the-extracellular-matrix-degradation-enzymes-and-promotes-wound-healing-of-3t3-fibroblasts-in-vitro
#11
Rukiye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29916120/silibinin-induced-autophagy-mediated-by-ppar%C3%AE-sirt1-ampk-pathway-participated-in-the-regulation-of-type-i-collagen-enhanced-migration-in-murine-3t3-l1-preadipocytes
#12
Xiaoling Liu, Qian Xu, Xinyu Long, Weiwei Liu, Yeli Zhao, Toshihiko Hayashi, Shunji Hattori, Hitomi Fujisaki, Takaaki Ogura, Shin-Ichi Tashiro, Satoshi Onodera, Masayuki Yamato, Takashi Ikejima
Preadipocyte migration is a fundamental and important process for the development of tissue organization, especially in the development of primitive adipose tissue and adipocyte tissue wound healing. However, excessive migration may result in abnormal development and fibrosis-related diseases such as hypertrophic scar. We previously reported that type I collagen (collagen I) enhanced migration of 3T3-L1 preadipocytes via phosphorylation and/or acetylation of NF-κB p65, and the enhanced cell migration is repressed by silibinin treatment through sirt1...
June 18, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29915804/using-advanced-wound-care-and-hyperbaric-oxygen-to-manage-wound-complications-following-treatment-of-vulvovaginal-carcinoma
#13
C Griffiths, R S Howell, H Boinpally, E Jimenez, E Chalas, F Musa, S Gorenstein
Postoperative management of patients with vulvar cancer is associated with a high incidence of poor wound healing and radiation -induced late tissue necrosis. This case series demonstrates the impact on wound healing with the use of hyperbaric oxygen therapy and advanced wound care following radical vulvectomy and/or radiation therapy. A retrospective case series was performed of all patients from 2016 to 2017 with lower genital cancer who underwent radical surgery with or without chemoradiation treatment, experienced wound dehiscence or late tissue radionecrosis, and were treated with advanced wound care, including hyperbaric oxygen therapy (HBO)...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29915632/incidence-causes-and-risk-factors-for-30-day-unplanned-reoperation-after-gastrectomy-for-gastric-cancer-experience-of-a-high-volume-center
#14
Hua Xiao, Yu Wang, Hu Quan, Yongzhong Ouyang
Background: To investigate the incidence, causes and risk factors for unplanned reoperation because of early complications within 30 days of radical gastrectomy for gastric cancer. Methods: The study cohort comprised 1,948 patients who underwent radical gastrectomy for gastric cancer between November 2010 and April 2017. The incidence, causes and outcomes of unplanned reoperation were examined and the risk factors were identified using univariate and multivariate analyses...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915573/functions-of-v%C3%AE-4-t-cells-and-dendritic-epidermal-t-cells-on-skin-wound-healing
#15
REVIEW
Yashu Li, Jun Wu, Gaoxing Luo, Weifeng He
Wound healing is a complex and dynamic process that progresses through the distinct phases of hemostasis, inflammation, proliferation, and remodeling. Both inflammation and re-epithelialization, in which skin γδ T cells are heavily involved, are required for efficient skin wound healing. Dendritic epidermal T cells (DETCs), which reside in murine epidermis, are activated to secrete epidermal cell growth factors, such as IGF-1 and KGF-1/2, to promote re-epithelialization after skin injury. Epidermal IL-15 is not only required for DETC homeostasis in the intact epidermis but it also facilitates the activation and IGF-1 production of DETC after skin injury...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915541/adm-scaffolds-generate-a-pro-regenerative-microenvironment-during-full-thickness-cutaneous-wound-healing-through-m2-macrophage-polarization-via-lamtor1
#16
Chengmin He, Zhi Yang, Ying Jin, Xiaoyang Qi, Jin Chu, Xiaoyuan Deng
Adult mammalian skin has a defective regenerative capacity following full-thickness cutaneous injury; this defect overshadows the complete physiological functions of the skin. Immune-mediated skin reconstruction driven by biological scaffolds is a recently developed innovative repair strategy to support regenerative wound healing. However, to date, little is known about how biological scaffolds orchestrate the immune response to promote regeneration. Here, using acellular dermal matrix (ADM) scaffolds, we discovered that the default pro-inflammatory response was altered in response to a pro-regenerative response characterized by specific M2 polarization...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29915432/%C3%AF-editors-choice%C3%AF-effects-of-exosomes-derived-from-the-induced-pluripotent-stem-cells-on-skin-wound-healing
#17
Hitoshi Kobayashi, Katsumi Ebisawa, Miki Kambe, Takatoshi Kasai, Hidetaka Suga, Kae Nakamura, Yuji Narita, Aika Ogata, Yuzuru Kamei
Recently, the effects of stem cell supernatants or exosomes, such as skin wounds, have attracted attention. However, the effects of the induced pluripotent stem (iPS) cell-derived exosomes (iPS-Exos) have not been investigated in detail. Here, we investigated the effects of iPS-Exos on skin wound healing using an animal model. We isolated iPS-Exos from the iPS cell culture media. Control exosomes were isolated from unused iPS cell culture media (M-Exos). We first observed the morphologic characteristics of the isolated exosomes and examined the expression of surface antigens...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914839/trends-of-30-day-mortality-and-morbidities-in-endovascular-repair-of-intact-abdominal-aortic-aneurysm-during-the-last-decade
#18
Kanhua Yin, Satinderjit S Locham, Marc L Schermerhorn, Mahmoud B Malas
OBJECTIVE: Significant research efforts have been made to improve the safety and efficacy of endovascular aneurysm repair (EVAR) in treating abdominal aortic aneurysm. This study aimed to examine the trends of perioperative outcomes of EVAR in the recent decade using a national validated database. METHODS: Patients who underwent EVAR for intact abdominal aortic aneurysm between 2006 and 2015 were identified from the National Surgical Quality Improvement Program and divided into early (2006-2010) and late (2011-2015) periods...
June 15, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29914830/clinical-factors-that-influence-the-cellular-responses-of-saphenous-veins-used-for-arterial-bypass
#19
Michael Sobel, Shinsuke Kikuchi, Lihua Chen, Gale L Tang, Tom N Wight, Richard D Kenagy
OBJECTIVE: When an autogenous vein is harvested and used for arterial bypass, it suffers physical and biologic injuries that may set in motion the cellular processes that lead to wall thickening, fibrosis, stenosis, and ultimately graft failure. Whereas the injurious effects of surgical preparation of the vein conduit have been extensively studied, little is known about the influence of the clinical environment of the donor leg from which the vein is obtained. METHODS: We studied the cellular responses of fresh saphenous vein samples obtained before implantation in 46 patients undergoing elective lower extremity bypass surgery...
June 15, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29914650/enzymes-as-green-catalysts-and-interactive-biomolecules-in-wound-dressing-hydrogels
#20
REVIEW
Georg M Guebitz, Gibson S Nyanhongo
Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emerging as alternative 'green catalyst' tools. Enzymes show great potential for the synthesis of complex multifunctional wound dressing hydrogels (WDHs) ex situ and in situ as well as in acting as interactive molecules to promote the wound healing process...
June 15, 2018: Trends in Biotechnology
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