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https://www.readbyqxmd.com/read/29691981/up-regulation-of-mir-10b-3p-promotes-the-progression-of-hepatocellular-carcinoma-cells-via-targeting-cmtm5
#1
Lianyue Guan, Degang Ji, Na Liang, Shuo Li, Baozhen Sun
In this study, we investigated how miR-10b-3p regulated the proliferation, migration, invasion in hepatocellular carcinoma (HCC) at both in vitro and in vivo levels. CMTM5 was among the differentially expressed genes (data from TCGA). The expression of miR-10b-3p and CMTM5 was detected by qRT-PCR and Western blot (WB). TargetScan was used to acquire the binding sites. Dual-luciferase reporter gene assay was used to verify the direct target relationship between miR-10b-3p and CMTM5. WB analysis proved that miR-10b-3p suppressed CMTM5 expression...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29691902/3d-printed-functional-and-biological-materials-on-moving-freeform-surfaces
#2
Zhijie Zhu, Shuang-Zhuang Guo, Tessa Hirdler, Cindy Eide, Xiaoxiao Fan, Jakub Tolar, Michael C McAlpine
Conventional 3D printing technologies typically rely on open-loop, calibrate-then-print operation procedures. An alternative approach is adaptive 3D printing, which is a closed-loop method that combines real-time feedback control and direct ink writing of functional materials in order to fabricate devices on moving freeform surfaces. Here, it is demonstrated that the changes of states in the 3D printing workspace in terms of the geometries and motions of target surfaces can be perceived by an integrated robotic system aided by computer vision...
April 25, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29691872/a-study-of-the-pharmacokinetics-and-thromboxane-inhibitory-activity-of-a-single-intramuscular-dose-of-carprofen-as-a-means-to-establish-its-potential-use-as-an-analgesic-drug-in-white-rhinoceros
#3
M Leiberich, R Krebber, M Hewetson, J Marais, V Naidoo
The alleviation of pain and prevention of suffering are key aspects of animal welfare. Unfortunately, analgesic drugs are not available for all species. White rhinoceros (Ceratotherium simum), representing one of such species, which survive poaching attempts inflicted with severe facial injuries and gunshot wounds, nonetheless require analgesic support. To improve treatment conditions, this study explored the use of carprofen for the treatment of pain and inflammation in white rhinoceros. The pharmacokinetics of 1 mg/kg intramuscular carprofen was evaluated in six healthy white rhinoceros...
April 24, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29691864/foxo1-transcriptional-activities-in-vegf-expression-and-beyond-a-key-regulator-in-functional-angiogenesis
#4
Bin Ren
FoxO1 has emerged as an important regulator of angiogenesis. Recent work published in this Journal shows that FoxO1 regulates VEGF expression in keratinocytes and is required for angiogenesis in wound healing. Since FoxO1 also regulates CD36 transcription, and endothelial cell differentiation and vascular maturation, this transcription factor may be essential for the formation of functional vascular networks via coupling the regulation of CD36 in vascular endothelial cells under physiological and pathological conditions...
April 24, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29691813/comparison-of-healing-of-full-thickness-skin-wounds-grafted-with-multidirectional-or-unidirectional-autologous-artificial-dermis-differential-delivery-of-healing-biomarkers
#5
M R Fontanilla, S Casadiegos, R H Bustos, M A Patarroyo
Cytokines, chemokines, and growth and remodeling factors orchestrate wound healing when skin damage occurs. During early stages, when the wound is still open, detection and quantification of these compounds might provide biomarkers of skin wound healing, which could aid to complete the scenario provided by clinical follow-up data and histological and histomorphometric analyses. This work assessed and compared the healing of full-thickness skin wounds grafted with artificial dermis made with autologous skin fibroblasts and unidirectional or multidirectional type I collagen scaffolds to test this hypothesis...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29691568/-treatment-of-48-cases-of-benign-lower-posterior-tumor-of-the-parotid-gland-with-c-shaped-small-incision
#6
Zhen-Ran Gao, Song-Bo Ma, Guo-Qin Zhang
PURPOSE: To summarize the feasibility and advantages of C-shaped small incision for the treatment of benign lower posterior tumor of the parotid gland. METHODS: Forty-eight cases of benign lower posterior tumor of the parotid gland were treated with C-shaped small incision. The treatment outcomes were recorded and analyzed. RESULTS: The wound healed primarily in all 48 cases. The follow-up period was 1-5 years, and there was no recurrence of tumor and the shape of parotid region recovered well...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691565/-effect-of-rhegf-on-the-levels-of-serum-egf-and-inflammatory-cytokines-in-patients-with-oral-and-maxillofacial-trauma
#7
Zhi-Fa Yin, Si-Ming Wang
PURPOSE: To investigate the effect of debridement combined with recombinant human epidermal growth factor (rhEGF) on wound healing, scar formation, serum epidermal growth factor and inflammatory factors in patients with oral and maxillofacial trauma. METHODS: Eight-two cases with oral and maxillofacial trauma treated in our hospital (January 2015 to December 2016) were retrospectively analyzed. All patients received routine treatment, 41 received rhEGF besides routine treatment (experimental group), 41 patients received only cosmetic debridement and suturing (control group)...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29691339/outbreak-of-invasive-wound-mucormycosis-in-a-burn-unit-due-to-multiple-strains-of-mucor-circinelloides-f-circinelloides-resolved-by-whole-genome-sequencing
#8
Dea Garcia-Hermoso, Alexis Criscuolo, Soo Chan Lee, Matthieu Legrand, Marc Chaouat, Blandine Denis, Matthieu Lafaurie, Martine Rouveau, Charles Soler, Jean-Vivien Schaal, Maurice Mimoun, Alexandre Mebazaa, Joseph Heitman, Françoise Dromer, Sylvain Brisse, Stéphane Bretagne, Alexandre Alanio
Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015)...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29691213/an-mhealth-app-for-decision-making-support-in-wound-dressing-selection-wounds-protocol-for-a-user-centered-feasibility-study
#9
Scott Jordan, Jane McSwiggan, Joanne Parker, Gayle A Halas, Marcia Friesen
BACKGROUND: Primary care health professionals, especially family physicians, see a variety of wounds, and yet-despite the frequency of providing wound care-many family physicians do not feel confident in wound care management. This is partly due to a lack of formal wound education in Family Medicine programs. While there are numerous electronic wound care resources available in the UK and North America, none were identified that address the specific need in supporting clinical decision-making in wound dressing selection...
April 24, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29691079/the-scleroderma-hand-manifestations-of-disease-and-approach-to-management
#10
REVIEW
Ariel A Williams, Hannah M Carl, Scott D Lifchez
Scleroderma is a rare autoimmune connective tissue disorder that often affects the hands. Manifestations in the hands include calcium deposits within the soft tissues that cause pain and may ulcerate through the skin, digital ischemia resulting in chronic wounds and digital gangrene, and joint contracture. Because of the underlying disease, patients with scleroderma have poorly vascularized tissue and a deficient soft tissue envelope, which make surgery particularly challenging. However, when undertaken with care, surgical intervention is often the best option for addressing the disabling hand conditions that so often accompany this disease...
April 21, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29691041/application-of-pre-contoured-anatomic-locking-plate-for-treatment-of-humerus-split-type-greater-tuberosity-fractures-a-prospective-review-of-68-cases-with-an-average-follow-up-of-2-5-years
#11
Chuanzhen Hu, Kaihua Zhou, Fugen Pan, Qilin Zhai, Weifeng Wen, Xiaojian He
OBJECTIVES: Although various implants exist for 3- and 4-part proximal humerus fractures, few implants are appropriate for humerus split type greater tuberosity fractures. The goal of this study was to assess the efficacy of pre-contoured anatomic locking plate for humerus split type greater tuberosity fractures. METHODS: A retrospective review of 68 patients with humerus split type greater tuberosity fractures treated with open reduction and internal fixation using anatomic locking plates between January 2014 and October 2016...
April 18, 2018: Injury
https://www.readbyqxmd.com/read/29691038/polyelectrolyte-complex-of-aloe-vera-chitosan-and-alginate-produced-fibroblast-and-lymphocyte-viabilities-and-migration
#12
Raquel Gallardo-Rivera, María de Los Ángeles Aguilar-Santamaría, Phaedra Silva-Bermúdez, Julieta García-López, Alberto Tecante, Cristina Velasquillo, Angélica Román-Guerrero, César Pérez-Alonso, Humberto Vázquez-Torres, Keiko Shirai
Chitosan, sodium alginate and gel of Aloe vera (Aloe barbadensis Miller) were employed for the preparation of polyelectrolyte complexes at pH 4 and 6. FT-IR spectroscopy analysis showed evidence on complexes formation and incorporation of the Aloe vera gel. The ζ potential determination of the polyelectrolyte complexes revealed the presence of surface charges in the range of -20 to -24 mV, which results in stable systems. The dynamic moduli exhibited a high dependence on angular frequency, which is commonly found in solutions of macromolecules...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29691034/physical-and-chemical-properties-percutaneous-absorption-promoting-effects-of-exopolysaccharide-produced-by-bacillus-atrophaeus-wyz-strain
#13
Wenjing Zhu, Yuzhen Wang, Fang Yan, Ruiteng Song, Zhijian Li, Yiqing Li, Bo Song
A high yield of exopolysaccharides bacteria isolated from mangrove system was identified as Bacillus atrophaeus by 16S rDNA and named as WYZ strain. An exopolysaccharide (BPS) was obtained from this strain after purification with a yield of about 0.58 g/L. Then some physical and chemical properties of BPS, such as weight average molecular weight (Mw), monosaccharide composition, intrinsic viscosity and water retention capacity were studied. The microstructure (SEM) showed that BPS was porous wound three-dimensional spider web structure...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29691018/carboxymethyl-chitosan-gelatin-hyaluronic-acid-blended-membranes-as-epithelia-transplanting-scaffold-for-corneal-wound-healing
#14
Wenhua Xu, Zheying Wang, Ying Liu, Liping Wang, Zhiwen Jiang, Tong Li, Wenhua Zhang, Ye Liang
There is an unmet need for an optimal scaffold as cell transplantation carrier to induce corneal reconstruction. In this study, a blend membrane was prepared with carboxymethyl chitosan (CMCTS), gelatin, and hyaluronic acid. To investigate its cytocompatibility, primary rabbit corneal epithelial cells (CEpCs) were seeded on it and growth and proliferation were evaluated. The blend membrane was found to be transparent, biodegradable, and suitable for CEpCs attachment and proliferation, which could maintain the epithelial cell-like protein expression of CEpCs...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29690894/uniportal-video-assisted-thoracoscopic-surgery-following-neoadjuvant-chemotherapy-for-locally-advanced-lung-cancer
#15
Zhiqiang Yang, Chunbo Zhai
BACKGROUND: Several retrospective studies have confirmed that video-assisted thoracoscopic surgery (VATS) following neoadjuvant chemotherapy is a safe and feasible treatment for advanced non-small cell lung cancer patients. As a minimally invasive technique, VATS usually leads to better clinical outcomes and better compliance with adjuvant treatment than conventional thoracotomy. Uniportal VATS (U-VATS) as an alternative option to conventional multi-port VATS has attracted much attention recently because reduced number and size of incisions may help to decrease inflammatory response and reduce postoperative pain for patients...
April 24, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29690892/the-efficacy-and-safety-of-topical-administration-of-tranexamic-acid-in-spine-surgery-a-meta-analysis
#16
Wei Luo, Ru-Xin Sun, Han Jiang, Xin-Long Ma
BACKGROUND: We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy and safety of tranexamic acid (TXA) in spine surgery. METHODS: Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966-2017.11), PubMed (1966-2017.11), Embase (1980-2017.11), and ScienceDirect (1985-2017.11). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5...
April 24, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29690856/human-amniotic-membrane-with-aligned-electrospun-fiber-as-scaffold-for-aligned-tissue-regeneration
#17
Hanis Nazihah Hasmad, Mohd Reusmaazran Yusof, Zainul Rashid Mohd Razi, Ruszymah Binti Haji Idrus, Shiplu Roy Chowdhury
Fabrication of composite scaffolds is one of the strategies proposed to enhance the functionality of tissue engineered scaffolds for improved tissue regeneration. By combining multiple elements together, unique biomimetic scaffolds with desirable physical and mechanical properties can be tailored for tissue-specific applications. Despite having a highly porous structure, the utility of electrospun fibers (EF) as scaffold is usually hampered by their insufficient mechanical strength. In this study, we attempted to produce a mechanically competent scaffold with cell-guiding ability by fabricating aligned PLGA fibers on decellularized human amniotic membrane (HAM), known to possess favorable tensile and wound healing properties...
April 25, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29690743/-advances-in-the-research-of-biomechanical-effects-of-negative-pressure-wound-therapy-in-promoting-wound-healing
#18
X Q Chen, W Zhang, X Y Li
Recently, researchers have focused on the micro-mechano-environment and the resulting mechanical cues which can regulate the morphology, structure, and function of cells. As a novel mechanotherapy, negative-pressure wound therapy (NPWT) has revolutionized the treatment of acute and chronic wounds. The effects of mechanics in use of NPWT has been noticed by researchers, and sporadic results have been reported, while the mechanisms of mechanosensitivity and mechanotransduction in affecting cell behaviors and promoting wound healing haven't been elucidated yet...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29690741/-antiseptic-effect-of-compound-lysostaphin-disinfectant-and-its-preventive-effect-on-infection-of-artificial-dermis-after-graft-on-full-thickness-skin-defect-wound-in-rats
#19
J Jin, H Zhou, Z C Cui, L Wang, P F Luo, S Z Ji, X Y Hu, B Ma, G Y Wang, S H Zhu, Z F Xia
Objective: To study the antiseptic effect of compound lysostaphin disinfectant and its preventive effect on infection of artificial dermis after graft on full-thickness skin defect wound in rats. Methods: (1) Each one standard strain of Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus were selected. Each 20 clinical strains of Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus were collected from those isolated from wound exudates of burn patients hospitalized in our wards from January 2014 to December 2016 according to the random number table...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29690740/-effects-of-exogenous-high-mobility-group-protein-box-1-on-angiogenesis-in-ischemic-zone-of-early-scald-wounds-of-rats
#20
L Dai, X Guo, H J Huang, X M Liao, X Q Luo, D Li, H Zhou, X C Gao, M Y Tan
Objective: To observe effects of exogenous high mobility group protein box 1 (HMGB1) on angiogenesis in ischemic zone of early scald wounds of rats. Methods: Thirty-six Sprague-Dawley rats were divided into HMGB1 group and simple scald (SS) group according to the random number table, with 18 rats in each group. Comb-like copper mould was placed on the back of rats for 20 s after being immersed in 100 ℃ hot water for 3 to 5 min to make three ischemic zones of wound. Immediately after scald, rats in HMGB1 group were subcutaneously injected with 0...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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