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https://www.readbyqxmd.com/read/29220878/a-qualitative-study-of-the-experience-of-lower-extremity-wounds-and-amputations-among-people-with-diabetes-in-philadelphia
#1
Frances K Barg, Peter F Cronholm, Ebony E Easley, Trocon Davis, Michelle Hampton, D Scot Malay, Cornelius Donohue, Jinsup Song, Stephen R Thom, David J Margolis
The purpose of this study was to explore perceptions among people with type 2 diabetes about foot ulcers and lower extremity amputations. This was a qualitative observational study utilizing open-ended, semistructured interviews of 39 people with diabetes who were purposively selected because they had either a foot ulcer (n = 19) or a lower extremity amputation (n = 20). Interviews were audio-recorded, deidentified, and entered into NVivo 10.0 for coding and analysis. Our integrated analytic approach combined inductively and deductively derived codes that were applied to all transcripts...
December 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29220392/safety-and-efficacy-of-the-prepex-device-in-hiv-positive-men-a-single-arm-study-in-zimbabwe
#2
Mufuta Tshimanga, Batsirai Makunike-Chikwinya, Tonderayi Mangwiro, Patricia Tapiwa Gundidza, Pesanai Chatikobo, Vernon Murenje, Amy Herman-Roloff, Peter H Kilmarx, Marrianne Holec, Gerald Gwinji, Owen Mugurungi, Munyaradzi Murwira, Sinokuthemba Xaba, Scott Barnhart, Caryl Feldacker
METHODS: We aimed to determine if the adverse event (AE) rate was non-inferior to an AE rate of 2%, a rate considered the global standard of MC safety. Study procedures, AE definitions, and study staff were unchanged from previous PrePex Zimbabwe trials. After PrePex placement and removal, weekly visits assessed wound healing. Men returned on Day 90. Safety was defined as occurrence of moderate and serious clinical AEs. Efficacy was defined as ability to reach the endpoint of complete circumcision...
2017: PloS One
https://www.readbyqxmd.com/read/29220362/optimized-plasma-preparation-is-essential-to-monitor-platelet-stored-molecules-in-humans
#3
Marion Mussbacher, Waltraud C Schrottmaier, Manuel Salzmann, Christine Brostjan, Johannes A Schmid, Patrick Starlinger, Alice Assinger
Platelets store a plethora of different molecules within their granules, modulating numerous pathways, not only in coagulation, but also in angiogenesis, wound healing, and inflammatory diseases. These molecules get rapidly released upon activation and therefore represent an easily accessible indirect marker for platelet activation. Accurate analysis of platelet-derived molecules in the plasma requires appropriate anticoagulation to avoid in vitro activation and subsequent degranulation of platelets, potentially causing artificially high levels and masking biologically relevant differences within translational research studies...
2017: PloS One
https://www.readbyqxmd.com/read/29220338/basics-of-compounding-compounding-irrigation-solutions-for-sterile-and-nonsterile-preparations
#4
Loyd V Allen
Compounding pharmacists are sometimes called upon to prepare irrigation solutions, especially in the hospital or clinical setting. Irrigations are indicated for washing or bathing surgical incisions, wounds, and body tissues, including body cavities. Some irrigation solutions coming in contact with exposed tissue, must meet stringent requirements of sterility and bacterial endotoxins. Compounded irrigation solutions may involve wound(s), the bladder, and also may be for ophthalmic, otic, and nasal application...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220299/perioperative-management-of-extremity-soft-tissue-sarcomas
#5
Rick L Haas, Alessandro Gronchi, Michiel A J van de Sande, Elizabeth H Baldini, Hans Gelderblom, Christina Messiou, Eva Wardelmann, Axel Le Cesne
Surgery is potentially curative for primary nonmetastatic extremity soft tissue sarcomas. After surgery alone, patients may remain at risk for local recurrences and/or metastatic disease. To reduce the likelihood of a local relapse, the addition of radiotherapy (RT) to limb-sparing surgery may result in higher local control rates of at least 85%. Generally, it can be stated that local control after both preoperative and postoperative RT is comparable, but that preoperative RT comes with a more favorable toxicity profile after prolonged follow-up, albeit at the cost of a higher wound complication rate...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218673/results-of-endoscopic-vacuum-assisted-closure-device-for-treatment-of-upper-gi-leaks
#6
Marc Bludau, Hans F Fuchs, Till Herbold, Martin K H Maus, Hakan Alakus, Felix Popp, Jessica M Leers, Christiane J Bruns, Arnulf H Hölscher, Wolfgang Schröder, Seung-Hun Chon
BACKGROUND: Esophageal perforations and postoperative leakage of esophagogastrostomies are considered to be life-threatening conditions due to the potential development of mediastinitis and consecutive sepsis. Vacuum-assisted closure (VAC) techniques, a well-established treatment method for superficial infected wounds, are based on a negative pressure applied to the wound via a vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy as a treatment for GI leakages in the rectum was introduced in 2008...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218671/robotic-versus-laparoscopic-right-colectomy-an-updated-systematic-review-and-meta-analysis
#7
Leonardo Solaini, Francesca Bazzocchi, Davide Cavaliere, Andrea Avanzolini, Alessandro Cucchetti, Giorgio Ercolani
BACKGROUND: In the right colon surgery, there is a growing literature comparing the safety of robotic right colectomy (RRC) to that of laparoscopic right colectomy (LRC). With this paper we aim to systematically revise and meta-analyze the latest comparative studies on these two minimally invasive procedures. METHODS: A systematic review of studies published from 2000 to 2017 in the PubMed, Scopus, and Embase databases was performed. Primary endpoints were postoperative morbidity and mortality...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218667/the-novel-trial-natural-orifice-versus-laparoscopic-cholecystectomy-a-prospective-randomized-evaluation
#8
Steven D Schwaitzberg, Kurt Roberts, John R Romanelli, David J Desilets, David Earle, Santiago Horgan, Lee Swanstrom, Eric Hungness, Nathaniel Soper, Michael L Kochman
INTRODUCTION: The evolution of Natural Orifice Translumenal Endoscopic Surgery® (NOTES®) represents a case study in surgical procedural evolution. Beginning in 2004 with preclinical feasibility studies, and followed by the creation of the NOSCAR® collaboration between The Society of American Gastrointestinal and Endoscopic Surgeons and the American Society for Gastrointestinal Endoscopy, procedural development followed a stepwise incremental pathway. The work of this consortium has included white paper analyses, obtaining outside independent funding for basic science and procedural development, and, ultimately, the initiation of a prospective randomized clinical trial comparing NOTES® cholecystectomy as an alternative procedure to laparoscopic cholecystectomy...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218659/single-site-robotic-assisted-laparoscopic-cholecystectomy-in-children-and-adolescents-a-report-of-20-cases
#9
Peter Mattei
BACKGROUND: Single-site laparoscopy is increasingly popular for straightforward operations like appendectomy. Due to limited triangulation and maneuverability, single-site cholecystectomy is riskier and more difficult. Robotics offer to make it easier and safer. METHODS: Twenty children and adolescents underwent robotic-assisted single-site cholecystectomy at a large academic children's hospital. Patients were not randomized; patients were offered the option of robotic-assisted single-site (SSR) or standard four-incision laparoscopic (LAP) cholecystectomy...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218493/direct-biological-effects-of-fractional-ultrapulsed-co2-laser-irradiation-on-keratinocytes-and-fibroblasts-in-human-organotypic-full-thickness-3d-skin-models
#10
L Schmitt, S Huth, P M Amann, Y Marquardt, R Heise, K Fietkau, L Huth, T Steiner, F Hölzle, J M Baron
Molecular effects of various ablative and non-ablative laser treatments on human skin cells-especially primary effects on epidermal keratinocytes and dermal fibroblasts-are not yet fully understood. We present the first study addressing molecular effects of fractional non-sequential ultrapulsed CO2 laser treatment using a 3D skin model that allows standardized investigations of time-dependent molecular changes ex vivo. While histological examination was performed to assess morphological changes, we utilized gene expression profiling using microarray and qRT-PCR analyses to identify molecular effects of laser treatment...
December 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29218300/the-dual-role-of-cellular-senescence-in-developing-tumors-and-their-response-to-cancer-therapy
#11
REVIEW
Markus Schosserer, Johannes Grillari, Michael Breitenbach
Cellular senescence describes an irreversible growth arrest characterized by distinct morphology, gene expression pattern, and secretory phenotype. The final or intermediate stages of senescence can be reached by different genetic mechanisms and in answer to different external and internal stresses. It has been maintained in the literature but never proven by clearcut experiments that the induction of senescence serves the evolutionary purpose of protecting the individual from development and growth of cancers...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29218292/primary-one-stage-reconstruction-in-complex-facial-avulsion-injury
#12
Abhishek Ghosh
Complex facial injuries with soft tissue degloving and bony avulsion are very devastating to the patient. Partial degloving injuries are described but hemifacial degloving with zygoma avulsion are rare. The author presents a case of post-traumatic degloving of the left upper lip, nose, part of forehead, upper and lower eyelids and cheek with avulsion of the left zygoma. The management included immediate resuscitation and early surgery to reposition the skeletal as well as soft tissue avulsion. The wound was thoroughly washed and primary repositioning and fixation were done...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218283/early-reconstructions-of-complex-lower-extremity-battlefield-soft-tissue-wounds
#13
Ali Ebrahimi, Nasrin Nejadsarvari, Azin Ebrahimi, Hamid Reza Rasouli
BACKGROUND: Severe lower extremity trauma as a devastating combat related injury is on the rise and this presents reconstructive surgeons with significant challenges to reach optimal cosmetic and functional outcomes. This study assessed early reconstructions of complex lower extremity battlefield soft tissue wounds. METHODS: This was a prospective case series study of battled field injured patients which was done in the Department of Plastic Surgery, Baqiyatallah University of Medical Sciences hospitals, Tehran, Iran between 2013-2015...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218280/the-effect-of-lithospermum-officinale-silver-sulfadiazine-and-alpha-ointments-in-healing-of-burn-wound-injuries-in-rat
#14
Zahra Mohtasham Amiri, Nader Tanideh, Anahita Seddighi, Maral Mokhtari, Masood Amini, Alborz Shakouri Partovi, Amir Manafi, Seyedeh Sara Hashemi, Davood Mehrabani
BACKGROUND: Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat. METHODS: Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine (SSD), gel base and L. officinale extract, respectively. A hot plate was used for induction of a standard 3rd degree burn wound...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218275/outcomes-of-surgical-excision-and-brachytherapy-in-intractable-keloids
#15
Ahmadreza Taheri, Hojjat Molaei, Mehdi Aghili, Naser Rahmanpanah, Atefeh Mirmohseni
BACKGROUND: Keloids as unusual scars are injury remnants characterized by bizarre cosmetics and painful itching. This study assessed outcomes of surgical excision and brachytherapy in intractable keloids. METHODS: Six patients with 10 keloid lesions were followed up. Surgical excision was done with 1-2 mm margin, and then radiotherapy was undertaken in 3 divided fractions on days 0, 1 and 2 after surgery. Scar improvement was evaluated by patients and observer with scar assessment scale (POSAS)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29218107/scutellarin-suppresses-human-colorectal-cancer-metastasis-and-angiogenesis-by-targeting-ephrinb2
#16
Ping Ting Zhu, Ming Mao, Zhao Guo Liu, Li Tao, Bing Chun Yan
Tumor induced angiogenesis is an attractive target for anti-cancer drug treatment. Scutellarin, which is a native compound derived from scutellaria altissima leaves, has already been proved to possess anti-tumor activities. Nevertheless, their effects in colorectal cancer metastasis and angiogenesis have not been evaluated. In order to reveal the anti-angiogenic and anti-metastasis capacity of scutellarin, wound healing and Transwell chamber inserts invasion were done in colorectal cancer cells, and cell proliferation as wells colony formation were conducted to identify the proliferation inhibition of colorectal cancer in vitro...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218091/angiogenic-and-wound-healing-potency-of-fermented-virgin-coconut-oil-in-vitro-and-in-vivo-studies
#17
Ahmad H Ibrahim, Haibo Li, Sawsan S Al-Rawi, Aman Shah Abdul Majid, Omar Am Al-Habib, Xiaobo Xia, Amin Ms Abdul Majid, Dan Ji
OBJECTIVE: The process of wound healing involves activation of keratinocytes, fibroblasts, endothelial cells, etc. Angiogenesis is crucial during the process of wound healing. Virgin coconut oil is widely utilized in South Asia for various purposes including food, medicinal and industrial applications. This study aimed to evaluate the potency of fermented virgin coconut oil (FVCO) in angiogenesis and wound healing via both in vitro and in vivo assays. METHODS: Human umbilical vein endothelial (HUVEC), fibroblast (CCD-18) and retinal ganglion (RGC-5) cells were cultured in medium containing different concentrations of FVCO...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218012/anti-tumor-effect-of-rhaponticum-uniflorum-ethyl-acetate-extract-by-regulation-of-peroxiredoxin1-and-epithelial-to-mesenchymal-transition-in-oral-cancer
#18
Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects. Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA) extracts were detected by ultra-performance liquid chromatography-Q/time-of-flight mass spectrometry (UPLC-Q/TOF-MS), followed by pharmacology-based network prediction analysis. The effects of RUEA extracts on proliferation, apoptosis, migration, and invasion ability of human oral squamous cell carcinoma (OSCC) cell line SCC15 were evaluated by CCK8 assay, Annexin V- fluorescein isothiocyanate/propidium iodide staining, wound healing assay, and Matrigel invasion assay, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29217927/magnitude-and-factors-associated-with-post-cesarean-surgical-site-infection-at-hawassa-university-teaching-and-referral-hospital-southern-ethiopia-a-cross-sectional-study
#19
Samuel Wodajo, Mehretu Belayneh, Samson Gebremedhin
Background: Surgical site infection (SSI) after cesarean section (CS) increases maternal morbidity, hospital stay and medical cost. However, in Ethiopia, limited evidence exists regarding the magnitude and risk factors of post-CS wound infection. The purpose of this study was to determine the prevalence of - and factors associated with the problem among mothers who gave birth in Hawassa University Teaching and Referral Hospital, Southern Ethiopia. Methods: Hospital based cross-sectional study was conducted based on the medical records of 592 women who underwent CS from June 2012 to May 2013...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217672/digital-ischemia-after-application-of-self-adherent-elastic-wrap-dressing-a-case-series
#20
Christopher A Makarewich, Penelope Lang, Douglas T Hutchinson
Self-adherent elastic wrap dressings are a convenient option to manage pediatric hand and finger injuries. However, when improperly applied, they have the potential to cause devastating complications. We detail in this report 5 cases of dressing-induced ischemic injury to the hand in pediatric patients with a review of the literature. All patients were treated by the senior author between 2007 and 2015 and were retrospectively reviewed for initial injury, frequency of dressing changes, presence of pain, time to evaluation by the orthopedic hand team, treatment, and outcome...
December 7, 2017: Pediatrics
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