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https://www.readbyqxmd.com/read/29667556/ultrasound-promoted-green-synthesis-docking-study-of-indole-spliced-thiadiazole-%C3%AE-amino-phosphonates-as-anticancer-agents-and-anti-tyrosinase-agents
#1
Anna Pratima G Nikalje, Pramod Gawhane, Shailee Tiwari, Jaiprakash Sangshetti, Manoj Damale
In this work, a new series of diethyl ((1H-indole-3-yl)((5-phenyl-1,3,4-thiadiazole-2- yl)amino)methyl)phosphonate derivatives 6(a-j) were designed and synthesized in Ultrasound by green protocol using Kabachnik-Fields reaction. The structures of the synthesized compounds were confirmed by spectral analysis such as elemental analyses, IR, 1H NMR, 13C NMR, 31P NMR and mass spectra. The synthesized compounds 6(a-j) were appraised for their in vitro anticancer activity against human cancer cell lines such as SK-MEL-2 (melanoma), IMR-32 (Neuroblastoma), HT-29(Colon) and also on normal murine embryonic fibroblast NIH/3T3 by Sulforhodamine B (SRB) assay, using Adriamycin as a standard drug...
April 17, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29663143/vertebral-body-osteonecrosis-proposal-of-a-treatment-oriented-classification-system
#2
Matteo Formica, Andrea Zanirato, Luca Cavagnaro, Marco Basso, Stefano Divano, Claudio Lamartina, Pedro Berjano, Lamberto Felli, Carlo Formica
PURPOSE: To present a classification system for vertebral body osteonecrosis (VBON) based on imaging findings and sagittal alignment and consequently to propose treatment guidelines. METHODS: Chart review and classification of imaging and clinical findings. An analysis of literature about VBON has been evaluated to conceive the classification. The current data allows to correlate radiological findings with different stages of the pathophysiological process and consequently to propose a patient-tailored treatment plan...
April 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29651869/new-mesh-type-phantoms-and-their-dosimetric-applications-including-emergencies
#3
C H Kim, Y S Yeom, T T Nguyen, M C Han, C Choi, H Lee, H Han, B Shin, J-K Lee, H S Kim, M Zankl, N Petoussi-Henss, W E Bolch, C Lee, B S Chung, R Qiu, K Eckerman
Committee 2 of the International Commission on Radiological Protection (ICRP) has constructed mesh-type adult reference computational phantoms by converting the voxel-type ICRP Publication 110 adult reference computational phantoms to a high-quality mesh format, and adding those tissues that were below the image resolution of the voxel phantoms and therefore not included in the Publication 110 phantoms. The new mesh phantoms include all the necessary source and target tissues for effective dose calculations, including the 8-40-µm-thick target layers of the alimentary and respiratory tract organs, thereby obviating the need for supplemental organ-specific stylised models (e...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29644483/studies-of-abnormalities-of-the-lower-esophageal-sphincter-during-esophageal-emptying-based-on-a-fully-coupled-bolus-esophageal-gastric-model
#4
Wenjun Kou, John E Pandolfino, Peter J Kahrilas, Neelesh A Patankar
The aim of this work was to develop a fully coupled bolus-esophageal-gastric model based on the immersed boundary-finite element method to study the process of esophageal emptying across the esophagogastric junction (EGJ). The model included an esophageal segment, an ellipsoid-shaped stomach, a bolus, and a simple model of the passive and active sphincteric functions of the lower esophageal sphincter (LES). We conducted three sets of case studies: (1) the effect of a non-relaxing LES; (2) the influence of the tissue anisotropy in the form of asymmetrical right- and left-sided compliance of the LES segment; and (3) the influence of LES and gastric wall stiffness on bulge formation of the distal esophageal wall...
April 11, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29644419/lower-lateral-cartilage-cephalic-malposition-an-over-diagnosed-entity
#5
Farhad Hafezi, Bijan Naghibzadeh, Abbas Kazemi Ashtiani
BACKGROUND: Lower lateral cartilage malposition is represented by anterior convexity of the lower lateral cartilage (LLC) dome with posterior pinch, as defined by Sheen and Constantian. This anatomic variation consists of cephalic, or upward and inward, rotation of lateral crura, particularly in bulbous tip patients. In most cases, "bulbous pinch" LLC is positioned toward the medial canthus, not laterally, so it is referred to as cephalic displacement. Accordingly, it is recommended to caudally displace cartilage in the majority of rhinoplasty cases in which variation is seen...
April 11, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29643812/left-ventricular-wall-stress-is-sensitive-marker-of-hypertrophic-cardiomyopathy-with-preserved-ejection-fraction
#6
Xiaodan Zhao, Ru-San Tan, Hak-Chiaw Tang, Soo-Kng Teo, Yi Su, Min Wan, Shuang Leng, Jun-Mei Zhang, John Allen, Ghassan S Kassab, Liang Zhong
Hypertrophic cardiomyopathy (HCM) patients present altered myocardial mechanics due to the hypertrophied ventricular wall and are typically diagnosed by the increase in myocardium wall thickness. This study aimed to quantify regional left ventricular (LV) shape, wall stress and deformation from cardiac magnetic resonance (MR) images in HCM patients and controls, in order to establish superior measures to differentiate HCM from controls. A total of 19 HCM patients and 19 controls underwent cardiac MR scans. The acquired MR images were used to reconstruct 3D LV geometrical models and compute the regional parameters (i...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29623349/three-cases-of-intracystic-papillary-neoplasm-of-gallbladder
#7
Naruki Mizobuchi, Jiro Munechika, Nobuyuki Takeyama, Yoshimitsu Ohgiya, Nobuyuki Ohike, Ryosuke Abe, Noritsugu Takahama, Osamu Miyagami, Kumi Hatano, Kumiko Ishizuka, Masanori Hirose, Takehiko Gokan
Intracystic papillary neoplasm (ICPN) of gallbladder is a comparatively new concept and is described as pre-malignant lesions in Nakanuma et al. (In: Bosman et al. (eds) WHO Classification of Tumours of the Digestive System, World Health Organization of Tumours, IARC, Lyon, 2010). ICPN with high-grade intraepithelial neoplasia is understood to include intraepithelial carcinoma or noninvasive carcinoma. And lesions with invasive cancer components are classified as ICPN with an associated invasive carcinoma [1]...
April 6, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29621552/a-mechanistic-study-on-tablet-ejection-force-and-its-sensitivity-to-lubrication-for-pharmaceutical-powders
#8
Bekuechukwu Uzondu, Lap Yin Leung, Chen Mao, Chia-Yi Yang
Pharmaceutical powders can exhibit markedly different tablet ejection forces. The purpose of this study is to understand the factors leading to the variability of the tablet ejection force and its sensitivity to lubrication. The study showed that the tablet ejection force is mainly governed by 1) tablet diameter and thickness, 2) compact-die wall friction coefficient, and 3) residual die wall stress upon ejection; the latter was further controlled by the maximum compression pressure, as well as the degree of non-elastic deformation during compression...
April 3, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29618890/modified-le-fort-iii-osteotomy-different-applications
#9
J M García Y Sánchez, C L Gómez Rodríguez, G Pacheco Rubio
Summary: Based on the new concepts of the modified Le Fort III osteotomy (MLFIIIO), Three variations of this technique are implemented: (A) the modified osteotomy Le Fort III Champy (1980) technique to be described with the use of surgical guides, and subciliary approach or an transconjunctival approach. Excellent technique for horizontal advancement no further to 6 mm, without requiring any type of graft.. (B) The modified Le Fort III osteotomy in "Z": to solve horizontal (posterior anterior) problems of more than 6 mm without bone grafting...
June 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29615690/porphyrins-inactivate-nosema-spp-microsporidia
#10
Aneta A Ptaszyńska, Mariusz Trytek, Grzegorz Borsuk, Katarzyna Buczek, Katarzyna Rybicka-Jasińska, Dorota Gryko
The study of organic/inorganic molecules with activity against intracellular fungi of the phylum Microsporidia is of critical importance. Here, for the first time, the inactivation of these parasitic fungi by porphyrins is reported. The biological effects of porphyrins (10 µM and 100 µM) on the microsporidian Nosema ceranae was investigated in honeybee hosts using cage experiments. A significant reduction in the number of spores (from 2.6 to 5 fold) was observed in Nosema-infected honeybees with a sucrose-protoporphyrin amide [PP(Asp)2 ] syrup diet compared to the control honeybees...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614620/cross-sectional-distributions-of-normal-and-abnormal-red-blood-cells-in-capillary-tubes-determined-by-a-new-technique
#11
Takahiro Sasaki, Junji Seki, Tomoaki Itano, Masako Sugihara-Seki
BACKGROUND: In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE: To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a new observation system for accurate measurements of radial RBC positions in the cross section of capillary tubes...
March 28, 2018: Biorheology
https://www.readbyqxmd.com/read/29609946/exercise-induced-cardiac-remodeling-in-athletes-and-in-special-forces-soldiers
#12
Paulo Dinis, Rogério Teixeira, Hélder Dores, Pedro Correia, Hanna Lekedal, Marie Bergman, Maria Carmo Cachulo, Joaquim Cardoso, Lino Gonçalves
INTRODUCTION: Exercise-induced cardiac remodeling is frequent in athletes. This adaptation is structurally manifested by an increase in cardiac dimensions and mass. Soldiers are also subject to intense physical exercise, although with different characteristics. OBJECTIVE: To compare exercise-induced cardiac remodeling in competitive athletes and in soldiers on a special forces training course. METHODS: We studied 17 soldiers (all male and Caucasian, mean age 21±3 years) who completed a special forces course and 17 basketball players (47...
March 30, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29607574/wall-shear-stress-estimation-in-the-aorta-impact-of-wall-motion-spatiotemporal-resolution-and-phase-noise
#13
Judith Zimmermann, Daniel Demedts, Hanieh Mirzaee, Peter Ewert, Heiko Stern, Christian Meierhofer, Bjoern Menze, Anja Hennemuth
BACKGROUND: Wall shear stress (WSS) presents an important parameter for assessing blood flow characteristics and evaluating flow-mediated lesions in the aorta. PURPOSE: To investigate the robustness of WSS and oscillatory shear index (OSI) estimation based on 4D flow MRI against vessel wall motion, spatiotemporal resolution, and velocity encoding (VENC). STUDY TYPE: Simulated and prospective. POPULATION: Synthetic 4D flow MRI data of the aorta, simulated using the Lattice-Boltzmann method; in vivo 4D flow MRI data of the aorta from healthy volunteers (n = 11) and patients with congenital heart defects (n = 17)...
April 1, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29607200/initial-experience-with-a-3d-printed-model-for-preoperative-simulation-of-the-nuss-procedure-for-pectus-excavatum
#14
Naoto Matsuo, Keitaro Matsumoto, Yasuaki Taura, Yuka Sakakibara, Daisuke Taniguchi, Katsunori Takagi, Yusuke Yamane, Masayuki Obatake, Naoya Yamasaki, Takeshi Nagayasu
The incidence of pectus excavatum has been estimated to be between 0.1% and 0.8% though a large autopsy series reports. After publication of the Nuss procedure for pectus excavatum, it became widely accepted. However, there are still some complications, such as over-correction and recurrence. To reduce differences in the procedure due to surgeons' experience level, preoperative simulation may be useful. Thus, we performed simulated surgery using a specific patient's three-dimensional (3D) chest wall model made by a 3D printer before operation...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606746/mechanical-properties-of-ten-egg-boxes-made-of-different-materials
#15
Ante Galic, Stjepan Pliestic, Dubravko Filipovic, Igor Kovacev, Kresimir Copec, Zlatko Janjecic, Dalibor Bedekovic
This study was conducted to evaluate mechanical properties of ten-egg boxes, which are the most commonly used egg boxes in many countries of Central and South-Eastern Europe. Six ten-egg boxes were tested, two made of cardboard, two made of expanded polystyrene and two made of general purpose solid polystyrene, each from a different producer. There were no significant differences in basic dimensions between tested boxes of various materials, while the significant differences were occurred in weight and box wall thickness...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29605193/the-contribution-of-thoracic-vertebral-deformity-and-arthropathy-to-trunk-pain-in-patients-with-chronic-obstructive-pulmonary-disease-copd
#16
Yi-Wen Chen, Harvey O Coxson, Tyler M Coupal, Stephen Lam, Peter L Munk, Jonathon Leipsic, W Darlene Reid
BACKGROUND: Pain, commonly localized to the trunk in individuals with COPD, may be due to osteoporosis-related vertebral deformity and chest wall hyper-expansion causing misalignment of joints between the ribs and vertebrae. The purpose of this study was to determine if thoracic vertebral deformity and arthropathy were independent contributors to trunk pain in COPD patients compared to people with a significant smoking history. METHOD: Participants completed the Brief Pain Inventory (BPI) on the same day as chest CT scans and spirometry...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29604881/molecular-simulation-of-capillary-phase-transitions-in-flexible-porous-materials
#17
Vincent K Shen, Daniel W Siderius, Nathan A Mahynski
We used flat-histogram sampling Monte Carlo to study capillary phase transitions in deformable adsorbent materials. Specifically, we considered a pure adsorbate fluid below its bulk critical temperature within a slit pore of variable pore width. The instantaneous pore width is dictated by a number of factors, such as adsorbate loading, reservoir pressure, fluid-wall interaction, and bare adsorbent properties. In the slit pores studied here, the bare adsorbent free energy was assumed to be biparabolic, consisting of two preferential pore configurations, namely, the narrow pore and the large pore configurations...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29602339/finite-element-analysis-of-slot-wall-deformation-in-stainless-steel-and-titanium-orthodontic-brackets-during-simulated-palatal-root-torque
#18
Varadaraju Magesh, Pandurangan Harikrishnan, Devadhas Kingsly Jeba Singh
INTRODUCTION: Torque applied on anterior teeth is vital for root positioning and stability. The aim of this study was to evaluate the detailed slot wall deformation in stainless steel (SS) and titanium (Ti) edgewise brackets during palatal root torque using finite element analysis. METHODS: A finite element model was developed from a maxillary central incisor SS bracket (0.022 in). The generated torque values from an SS rectangular archwire (0.019 × 0.025 in) while twisting from 5° to 40° were obtained experimentally by a spine tester, and the calculated torque force was applied in the bracket slot...
April 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29578470/development-of-asymmetric-stent-for-treatment-of-eccentric-plaque
#19
Achmad Syaifudin, Ryo Takeda, Katsuhiko Sasaki
The selection of stent and balloon type is decisive in the stenting process. In the treatment of an eccentric plaque obstruction, a symmetric expansion from stent dilatation generates nonuniform stress distribution, which may aggravate fibrous cap prone to rupture. This paper developed a new stent design to treat eccentric plaque using structural transient dynamic analysis in ANSYS. A non-symmetric structural geometry of stent is generated to obtain reasonable stress distribution safe for the arterial layer surrounding the stent...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29577117/modulation-of-whey-protein-kappa-carrageenan-hydrogel-properties-via-enzymatic-protein-modification
#20
Michael J Selig, B N Dar, Arkaye Kierulf, Raheleh Ravanfar, Syed S H Rizvi, Alireza Abbaspourrad
Treatment of whey protein isolate (WPI; 1 to 25% w/w) in heated κ-carrageenan (KC; 2% w/w) slurries with protease and/or transglutaminase modulated the properties of the hydrogels formed after cooling. Observation of peak compression stress and strain at gel rupture showed WPI incorporation at 1, 5 and 10% (w/w) significantly reduced the strength and deformability of 2% (w/w) KC gels. Treatment of WPI solutions in KC slurries with Alcalase 2.4L was shown by both SDS-Page and size exclusion HPLC to reduce protein/peptide molecular weight distributions below 10 kDa, with large portions below 1 kDa...
March 26, 2018: Food & Function
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