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https://www.readbyqxmd.com/read/28214505/positional-right-ventricular-obstruction-in-pectus-excavatum
#1
Katherine Underwood, Matthew Vorsanger, Muhamed Saric, Adam H Skolnick
Pectus excavatum is one of the most common congenital chest wall deformities. The degree of sternal depression, which may result in compression of the right heart by the chest wall, is variable. While typically asymptomatic, there are various symptoms that can result from severe pectus excavatum. We report on a patient with severe pectus excavatum leading to dynamic obstruction of the right ventricular outflow tract in the seated position.
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28214368/evaluation-of-deformable-image-registration-between-external-beam-radiotherapy-and-hdr-brachytherapy-for-cervical-cancer-with-a-3d-printed-deformable-pelvis-phantom
#2
Noriyuki Kadoya, Yuya Miyasaka, Yujiro Nakajima, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Suguru Dobashi, Takaya Yamamoto, Noriyoshi Takahashi, Masaki Kubozono, Ken Takeda, Keiichi Jingu
PURPOSE: In this study, we developed a 3D-printed deformable pelvis phantom for evaluating spatial DIR accuracy. We then evaluated the spatial DIR accuracies of various DIR settings for cervical cancer. METHODS: A deformable female pelvis phantom was created based on patient CT data using 3D printing. To create the deformable uterus phantom, we first 3D printed both a model of uterus and a model of the internal cavities of the vagina and uterus. We then made a mold using the 3D printed uterus phantom...
February 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28210715/feasibility-and-reproducibility-of-two-dimensional-wall-motion-tracking-wmt-in-fetal-echocardiography
#3
Christian Enzensberger, Friederike Achterberg, Jan Degenhardt, Aline Wolter, Oliver Graupner, Johannes Herrmann, Roland Axt-Fliedner
Objective The primary objective of this study was to determine the feasibility and reproducibility of 2-dimensional speckle tracking imaging based on the wall motion tracking (WMT) technique in fetal echocardiography. The secondary objective was to compare left and right ventricular global and segmental longitudinal peak strain values. Methods A prospective cross-sectional study was performed. Global and segmental longitudinal peak strain values of the left ventricle (LV) and right ventricle (RV) were assessed prospectively...
February 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28209527/exploring-deformable-particles-in-vascular-targeted-drug-delivery-softer-is-only-sometimes-better
#4
Margaret B Fish, Catherine A Fromen, Genesis Lopez-Cazares, Alexander W Golinski, Timothy F Scott, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
The ability of vascular-targeted drug carriers (VTCs) to localize and bind to a targeted, diseased endothelium determines their overall clinical utility. Here, we investigate how particle modulus and size determine adhesion of VTCs to the vascular wall under physiological blood flow conditions. In general, deformable microparticles (MPs) outperformed nanoparticles (NPs) in all experimental conditions tested. Our results indicate that MP modulus enhances particle adhesion in a shear-dependent manner. In low shear human blood flow profiles in vitro, low modulus particles showed favorable adhesion, while at high shear, rigid particles showed superior adhesion...
February 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28199083/shape-memory-hydrogels-evolution-of-structural-principles-to-enable-shape-switching-of-hydrophilic-polymer-networks
#5
Candy Löwenberg, Maria Balk, Christian Wischke, Marc Behl, Andreas Lendlein
The ability of hydrophilic chain segments in polymer networks to strongly interact with water allows the volumetric expansion of the material and formation of a hydrogel. When polymer chain segments undergo reversible hydration depending on environmental conditions, smart hydrogels can be realized, which are able to shrink/swell and thus alter their volume on demand. In contrast, implementing the capacity of hydrogels to switch their shape rather than volume demands more sophisticated chemical approaches and structural concepts...
February 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28188386/improved-identifiability-of-myocardial-material-parameters-by-an-energy-based-cost-function
#6
Anastasia Nasopoulou, Anoop Shetty, Jack Lee, David Nordsletten, C Aldo Rinaldi, Pablo Lamata, Steven Niederer
Myocardial stiffness is a valuable clinical biomarker for the monitoring and stratification of heart failure (HF). Cardiac finite element models provide a biomechanical framework for the assessment of stiffness through the determination of the myocardial constitutive model parameters. The reported parameter intercorrelations in popular constitutive relations, however, obstruct the unique estimation of material parameters and limit the reliable translation of this stiffness metric to clinical practice. Focusing on the role of the cost function (CF) in parameter identifiability, we investigate the performance of a set of geometric indices (based on displacements, strains, cavity volume, wall thickness and apicobasal dimension of the ventricle) and a novel CF derived from energy conservation...
February 10, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28185419/accumulation-of-rectum-dose-volume-metrics-for-prostate-external-beam-radiotherapy-combined-with-brachytherapy-evaluating-deformably-registered-dose-distribution-addition-using-parameter-based-addition
#7
Calyn R Moulton, Michael J House, Victoria Lye, Colin I Tang, Michele Krawiec, David J Joseph, James W Denham, Martin A Ebert
INTRODUCTION: To investigate the accuracy of deriving dose-volume histogram (DVH) parameters from deformably registered data by comparing values with the simple addition of DVHs from each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR-BT) brachytherapy prostate treatment. METHODS: Eighty-two patients received EBRT in 23 fractions of 2 Gy and HDR-BT TG43 in three fractions of 6.5 Gy. The HDR-BT CT was deformably registered to the EBRT CT...
February 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28177931/two-component-spin-coated-ag-cnt-composite-films-based-on-a-silver-heterogeneous-nucleation-mechanism-adhesion-enhanced-by-mechanical-interlocking-and-chemical-grafting
#8
Yang Zhang, Zhixin Kang, Takeshi Bessho
In this paper, a new method for the synthesis of silver carbon nanotube (Ag/CNT) composite films as conductive connection units for flexible electronic devices is presented. This method is about a two-component solution process by spin coating with an after-treatment annealing process. In this method, multi-walled carbon nanotubes (MWCNTs) act as the core of silver heterogeneous nucleation, which can be observed and analyzed by a field-emission scanning electron microscope. With the effects of mechanical interlocking, chemical grafting, and annealing, the interfacial adhesive strength between films and PET sheets was enhanced to 12 N cm(-1)...
March 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28167875/locking-plate-arthrodesis-compares-favorably-with-lrti-for-thumb-trapeziometacarpal-arthrosis-early-outcomes-from-a-longitudinal-cohort-study
#9
Nikolas H Kazmers, K J Hippensteel, Ryan P Calfee, Lindley B Wall, Martin I Boyer, Charles A Goldfarb, Richard H Gelberman, Daniel A Osei
BACKGROUND: Trapeziometacarpal arthrodesis (TMA) has been complicated by nonunion and hardware failure. QUESTIONS/PURPOSES: We hypothesized that modification of the TMA technique with a locking cage plate construct would afford reliable bony union while producing greater hand function than trapeziectomy with ligament reconstruction and tendon interposition (LRTI) at early follow-up. METHODS: We enrolled 36 consecutive patients with trapeziometacapal osteoarthritis (14 TMA patients (15 thumbs), 22 LRTI patients (22 thumbs))...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28165159/assessment-of-myocardial-ischemia-by-strain-dobutamine-stress-echocardiography-and-cardiac-magnetic-resonance-perfusion-imaging-before-and-after-coronary-artery-bypass-grafting
#10
Assami Rösner, Henrik Schirmer, Amjid Iqbal, Bart Bijnens, Derk Avenarius, Siri Malm
BACKGROUND: Following coronary artery bypass grafting (CABG), testing for myocardial ischemia by noninvasive imaging is often hampered by false-positive results. The aim of this study was to find test parameters with the best potential to identify myocardial ischemia in post-CABG patients. METHODS: Fifty-two consecutive patients scheduled for CABG, underwent both dobutamine stress echocardiography (DSE) and cardiac magnetic resonance first-pass perfusion imaging (CMR-FPPI) with adenosine vasodilation, before and 8-10 months after the surgical revascularization...
February 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28160266/investigation-of-stent-implant-mechanics-using-linear-analytical-and-computational-approach
#11
Hua Yang, Aleksandra Fortier, Kyle Horne, Atif Mohammad, Subhash Banerjee, Hai-Chao Han
Stent implants are essential in restoring normal blood flow in atherosclerotic arteries. Recent studies have shown high failure rates of stent implants in superficial femoral artery (SFA) as a result of dynamic loading environment imposed on the stent implants by the diseased arterial wall and turbulent blood flow. There are variety of stent designs and materials currently on the market however, there is no clear understanding if specific stent design is suitable with the material that is manufactured from and if this combination can sustain the life-cycle that the stent implants need to undergo once inside the artery...
February 3, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28145932/a-surgical-technique-for-management-of-the-metopic-suture-in-syndromic-craniosynostosis
#12
Jose Rolando Prada-Madrid, Lina Patricia Franco-Chaparro, Miguel Garcia-Wenninger, Tatiana Palomino-Consuegra, Nora Stanford, Diego Alejandro Castañeda-Hernández
OBJECTIVES: The objective is to describe a new surgical procedure developed in the San Jose Pediatric University Hospital for the management of syndromic synostosis of the metopic suture in a patient clinically diagnosed with Saethre-Chotzen syndrome. METHODS: The diagnosis of Saethre-Chotzen syndrome, bilateral coronal sutures, and metopic suture synostoses was made through photographic, anthropometric, exophthalmometric, and computed tomography analysis. The keel-like frontal bone deformity was corrected following resection using a fusiform osteotomy, remodelling was obtained by milling the edges, and the bony fragments were repositioned and fixed on the posterior wall of the frontal bone...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28143694/quantitative-computed-tomography-imaging-based-clustering-differentiates-asthmatic-subgroups-with-distinctive-clinical-phenotypes
#13
Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Mario Castro, Sean Fain, Nizar Jarjour, Mark L Schiebler, Kun Chen, Ching-Long Lin
BACKGROUND: Imaging variables including airway diameter, wall thickness and air-trapping have been found to be important metrics when differentiating severe asthmatics from nonsevere asthmatics and healthy subjects. OBJECTIVE: The objective of this study was to identify imaging-based clusters and to explore the association of the clusters with existing clinical metrics. METHODS: We performed an imaging-based cluster analysis using quantitative computed tomography-based structural and functional variables extracted from the respective inspiration and expiration scans of 248 asthmatics...
January 28, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28127347/tegumental-effects-of-methanolic-extract-of-balanites-aegyptiaca-fruits-on-adult-paramphistomum-microbothrium-fischoeder-1901-under-laboratory-conditions
#14
Hatem Shalaby, Soad Nasr, Tarek Farag
BACKGROUND: Weak efficacy of different fasciolicidal compounds used for treatment of paramphistomosis has drawn the attention of many authors to alternative drugs. The purpose of this study was to assess, for the first time, the effect of the methanolic extract of Balanites aegyptiaca fruits (BAE) on adult Paramphistomum microbothrium. METHODS: The effect of BAE on adult P. microbothrium after 24 h incubating the parasites in RPMI 1640 culture medium containing 10, 50, 100 and 200 μg/ml BAE was determined by light and scanning electron microscopic studies...
July 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28123506/ultrasound-and-differential-diagnosis-of-fetal-abdominal-cysts
#15
Chang-Yu Tu
The present study aimed to investigate the use of ultrasound and differential diagnosis to diagnose a fetal abdominal cyst. A retrospective analysis of 41 cases of fetal abdominal cyst, which included ovarian cysts, choledochal cysts, intestinal duplication and mesenteric cysts, was performed. Imaging characteristics of various types of cysts were summarized, compared and discussed. Among 41 fetal abdominal cyst cases, there were 21 cases of ovarian cysts, 11 cases of bile duct cyst, six cases of intestinal duplication and three cases of mesenteric cyst...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28117428/focusing-and-alignment-of-erythrocytes-in-a-viscoelastic-medium
#16
Taesik Go, Hyeokjun Byeon, Sang Joon Lee
Viscoelastic fluid flow-induced cross-streamline migration has recently received considerable attention because this process provides simple focusing and alignment over a wide range of flow rates. The lateral migration of particles depends on the channel geometry and physicochemical properties of particles. In this study, digital in-line holographic microscopy (DIHM) is employed to investigate the lateral migration of human erythrocytes induced by viscoelastic fluid flow in a rectangular microchannel. DIHM provides 3D spatial distributions of particles and information on particle orientation in the microchannel...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28117351/differential-growth-of-the-northern-tibetan-margin-evidence-for-oblique-stepwise-rise-of-the-tibetan-plateau
#17
Fei Wang, Wenbei Shi, Weibin Zhang, Lin Wu, Liekun Yang, Yinzhi Wang, Rixiang Zhu
Models of how high elevations formed across Tibet predict: (a) the continuous thickening of a "viscous sheet"; (b) time-dependent, oblique stepwise growth; and (c) synchronous deformation across Tibet that accompanied collision. Our new observations may shed light on this issue. Here, we use (40)Ar/(39)Ar and (U-Th)/He thermochronology from massifs in the hanging walls of thrust structures along the Kunlun Belt, the first-order orogenic range at the northern Tibetan margin, to elucidate the exhumation history...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115028/post-transitional-adaptation-of-the-left-heart-in-uncomplicated-very-preterm-infants
#18
Koert De Waal, Nilkant Phad, Anil Lakkundi, Peter Tan
BACKGROUND: The postnatal period in preterm infants involves multiple physiological changes occurring immediately after birth and continuing for days or weeks. To recognise and treat compromise, it is important to measure cardiovascular function. The aim of this study was to describe longitudinal left ventricular function using conventional and novel echocardiography techniques in preterm infants who did not experience significant antenatal or postnatal complications and treatments. METHODS: We prospectively obtained cardiac ultrasound images at days 3, 7, 14, 21, and 28 in 25 uncomplicated, preterm infants <30 weeks of gestation...
January 24, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28113704/infarct-localization-from-myocardial-deformation-prediction-and-uncertainty-quantification-by-regression-from-a-low-dimensional-space
#19
Nicolas Duchateau, Mathieu De Craene, Pascal Allain, Eric Saloux, Maxime Sermesant
Diagnosing and localizing myocardial infarct is crucial for early patient management and therapy planning. We propose a new method for predicting the location of myocardial infarct from local wall deformation, which has value for risk stratification from routine examinations such as (3D) echocardiography. The pipeline combines non-linear dimensionality reduction of deformation patterns and two multi-scale kernel regressions. Confidence in the diagnosis is assessed by a map of local uncertainties, which integrates plausible infarct locations generated from the space of reduced dimensionality...
May 3, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28113125/mechanism-of-drug-release-from-silica-gelatin-aerogel-relationship-between-matrix-structure-and-release-kinetics
#20
Péter Veres, Mónika Kéri, István Bányai, István Lázár, István Fábián, Concepción Domingo, József Kalmár
Specific features of a silica-gelatin aerogel (3 wt.% gelatin content) in relation to drug delivery has been studied. It was confirmed that the release of both ibuprofen (IBU) and ketoprofen (KET) is about tenfold faster from loaded silica-gelatin aerogel than from pure silica aerogel, although the two matrices are structurally very similar. The main goal of the study was to understand the mechanistic background of the striking difference between the delivery properties of these closely related porous materials...
January 17, 2017: Colloids and Surfaces. B, Biointerfaces
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