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https://www.readbyqxmd.com/read/29793215/in-silico-insight-into-voltage-gated-sodium-channel-1-7-inhibition-for-anti-pain-drug-discovery
#1
Mingxing Wang, Wei Li, Ying Wang, Yongbo Song, Jian Wang, Maosheng Cheng
Studies on human genetics have implicated the voltage-gated sodium channel Nav1.7 as an appealing target for the treatment of pain. In this study, we put forward a ligand-based pharmacophore for the first time, which was generated by a set of multiple chemical scaffolds including sulfonamide and non-sulfonamide derivatives and consisted of four chemical features: an aromatic ring, a hydrophobic group and two hydrogen acceptors. The active cavity was divided into three regions according to the properties of the amino acids surrounded and was used for the docking of 16 known active inhibitors...
May 18, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29793212/should-we-excise-are-there-any-clinical-or-histologic-features-that-predict-upgrade-in-papillomas-incidental-or-non-incidental
#2
Michael Zaleski, Yun An Chen, Alison L Chetlen, Julie Mack, Liyan Xu, Daleela G Dodge, Dipti M Karamchandani
The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. 253/296 (85.5%) cases were non-incidental, and 43/296 (14.5%) were incidental...
May 11, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29793208/enhanced-phosphate-removal-from-wastewater-by-using-in-situ-generated-fresh-trivalent-fe-composition-through-the-interaction-of-fe-ii-on-caco-3
#3
Yujie Li, Xiaoman He, Huimin Hu, Tingting Zhang, Jun Qu, Qiwu Zhang
Excessive existences of nutrients such as phosphate in the aqueous environment remain as a heavy concern although many researches have been reported for dealing with their removal. Based on the understanding toward the interactions of Fe compounds with phosphate and carbonate from many available researches, we designed a very simple and efficient approach for phosphate removal by using in situ generated fresh trivalent Fe composition through the interaction of Fe(II) as FeSO4 on CaCO3 . Addition and agitation of Fe(II) and CaCO3 simultaneously to phosphate solution allowed an amorphous Fe(III)-P or Ca-Fe(III)-P precipitation, with a phosphate removal rate close to 100%, to reduce the residual phosphorus concentration less than 0...
May 21, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29793206/effects-on-the-hepatic-transcriptome-of-chicken-embryos-in-ovo-exposed-to-phenobarbital
#4
Jiahua Guo, Shohei Ito, Hoa Thanh Nguyen, Kimika Yamamoto, Hisato Iwata
This work aimed at evaluating the toxic effects of in ovo exposure to phenobarbital (PB) and unveiling the mode of action by transcriptome analysis in the embryonic liver of a model avian species, chicken (Gallus gallus). Embryos were initially treated with saline or 1 μg PB /g egg at Hamburger Hamilton Stage (HHS) 1 (1st day), followed by 20 days of incubation to HHS 46. At 21st day, chicks that pipped successfully were euthanized and dissected for assessing the PB caused effects on phenotypes and the liver transcriptome in both genders...
May 21, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29793187/stapp-spatiotemporal-analysis-of-plantar-pressure-measurements-using-statistical-parametric-mapping
#5
Brian G Booth, Noël L W Keijsers, Jan Sijbers, Toon Huysmans
BACKGROUND: Pedobarography produces large sets of plantar pressure samples that are routinely subsampled (e.g. using regions of interest) or aggregated (e.g. center of pressure trajectories, peak pressure images) in order to simplify statistical analysis and provide intuitive clinical measures. RESEARCH QUESTION: We hypothesize that these data reductions discard gait information that can be used to differentiate between groups or conditions. METHODS: To test the hypothesis of null information loss, we created an implementation of statistical parametric mapping (SPM) for dynamic plantar pressure datasets (i...
May 3, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29793180/insulin-is-a-potential-antioxidant-for-diabetes-associated-cognitive-decline-via-regulating-nrf2-dependent-antioxidant-enzymes
#6
Ying Song, Wei Ding, Yun Bei, Yan Xiao, Hai-Da Tong, Li-Bo Wang, Li-Yao Ai
PURPOSE: To investigate the neuroprotective effects of insulin on diabetic encephalopathy and its mechanism. EXPERIMENTAL AND APPROACH: The diabetic model was established by injection of streptozotocin. Behavior examinations were conducted by the Morris water maze. Histopathological alterations were detected by HE staining. ROS, CAT levels and SOD activity were measured using a microplate reader. In vitro, the viability of wild type and knock-down PC12 cells was detected by MTT assay, the morphology of cells was monitored under a microscope...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793175/apolipoprotein-ciii-and-n-terminal-prohormone-b-type-natriuretic-peptide-as-independent-predictors-for-cardiovascular-disease-in-type-2-diabetes
#7
Marco Colombo, Helen C Looker, Bassam Farran, Felix Agakov, M Julia Brosnan, Paul Welsh, Naveed Sattar, Shona Livingstone, Paul N Durrington, D John Betteridge, Paul M McKeigue, Helen M Colhoun
BACKGROUND AND AIMS: Developing sparse panels of biomarkers for cardiovascular disease in type 2 diabetes would enable risk stratification for clinical decision making and selection into clinical trials. We examined the individual and joint performance of five candidate biomarkers for incident cardiovascular disease (CVD) in type 2 diabetes that an earlier discovery study had yielded. METHODS: Apolipoprotein CIII (apoCIII), N-terminal prohormone B-type natriuretic peptide (NT-proBNP), high sensitivity Troponin T (hsTnT), Interleukin-6, and Interleukin-15 were measured in baseline serum samples from the Collaborative Atorvastatin Diabetes trial (CARDS) of atorvastatin versus placebo...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29793171/compositional-engineering-of-acceptors-for-highly-efficient-bulk-heterojunction-hybrid-organic-solar-cells
#8
S Amber Yousaf, M Ikram, S Ali
The wet chemical synthesis of chromium oxide (Cr2 O3 ) nanoparticles (NPs) and its application in active layer of inverted bulk heterojunction organic solar cells is documented in this research. Chromium oxide NPs of 10-30 nm size range having a band gap of 2.9 eV were successfully synthesized. These NPs were used in inverted organic solar cells in amalgamation with P3HT:PCBM and PTB7:PCBM polymers. The fabricated hybrid devices improves PCE significantly for P3HT:PCBM and PTB7:PCBM systems. The photophysical energy levels, optoelectrical properties and microscopic images have been systematically studied for the fabricated devices...
May 21, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793169/spontaneous-rise-in-open-rectangular-channels-under-gravity
#9
Vignesh Thammanna Gurumurthy, Ilia V Roisman, Cameron Tropea, Stephen Garoff
Fluid movement in microfluidic devices, porous media, and textured surfaces involves coupled flows over the faces and corners of the media. Spontaneous wetting of simple grooved surfaces provides a model system to probe these flows. This numerical study investigates the spontaneous rise of a liquid in an array of open rectangular channels under gravity, using the Volume-of-Fluid method with adaptive mesh refinement. The rise is characterized by the meniscus height at the channel center, outer face and the interior and exterior corners...
May 17, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793168/olive-oil-polyphenols-reduce-oxysterols-induced-redox-imbalance-and-pro-inflammatory-response-in-intestinal-cells
#10
Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M Paola Melis, Carlo I G Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial layer and thus contributing to the pathogenesis of human inflammatory bowel diseases and colon cancer. Extra virgin olive oil polyphenols possess antioxidant and anti-inflammatory properties, and concentrate in the intestinal lumen, where may help in preventing intestinal diseases...
May 16, 2018: Redox Biology
https://www.readbyqxmd.com/read/29793167/improvement-of-neuronal-differentiation-by-carbon-monoxide-role-of-pentose-phosphate-pathway
#11
Ana S Almeida, Nuno L Soares, Catarina O Sequeira, Sofia A Pereira, Ursula Sonnewald, Helena L A Vieira
Over the last decades, the silent-killer carbon monoxide (CO) has been shown to also be an endogenous cytoprotective molecule able to inhibit cell death and modulate mitochondrial metabolism. Neuronal metabolism is mostly oxidative and neurons also use glucose for maintaining their anti-oxidant status by generation of reduced glutathione (GSH) via the pentose-phosphate pathway (PPP). It is established that neuronal differentiation depends on reactive oxygen species (ROS) generation and signalling, however there is a lack of information about modulation of the PPP during adult neurogenesis...
May 15, 2018: Redox Biology
https://www.readbyqxmd.com/read/29793162/new-insights-into-the-formation-of-silver-based-nanoparticles-under-natural-and-semi-natural-conditions
#12
Andreas Wimmer, Anna Kalinnik, Michael Schuster
For the first time, the natural formation of silver-based nanoparticles (Ag-b-NPs) was studied in field investigations of two pre-alpine lakes in Germany that contain geogenic silver traces in the sub-ng L-1 range. Light-sensitive microorganisms most likely accumulate and transport these silver traces from deeper water layers to the surface. At the surface of the eutrophic lake, approximately 40% of total silver (5.7 ng L-1 ) consisted of Ag-b-NPs, whereas in the oligotrophic lake with similar enrichment of silver species, no Ag-b-NPs were detected...
May 10, 2018: Water Research
https://www.readbyqxmd.com/read/29793159/impacts-of-groundwater-management-on-energy-resources-and-greenhouse-gas-emissions-in-california
#13
Thomas P Hendrickson, Maya Bruguera
California faces significant energy and water infrastructure planning challenges in response to a changing climate. Immediately following the most severe recorded drought, the state experienced one of its wettest water years in recorded history. Despite the recent severe wet weather, much of the state's critical groundwater systems have not recovered from the drought. The recent Sustainable Groundwater Management Act (SGMA) aims to eliminate future depletion risks, but may force California basins to seek alternative water sources by limiting groundwater withdrawals during droughts...
May 16, 2018: Water Research
https://www.readbyqxmd.com/read/29793158/botulinum-toxin-type-a-affects-mechanics-of-non-injected-antagonistic-rat-muscles
#14
Filiz Ateş, Can A Yucesoy
Botulinum toxin type A (BTX-A) effects on the mechanics of non-injected antagonistic muscles are unknown. The aim was to test the following hypotheses in a rat model: BTX-A injected into gastrocnemius medialis (GM) and lateralis (GL) (1) decreases forces of the antagonistic tibialis anterior (TA) and extensor digitorum longus (EDL), (2) reduces length range of force exertion and (3) increases passive forces of the TA, and (4) changes inter-antagonistic and inter-synergistic epimuscular myofascial force transmission (EMFT)...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793149/educational-and-emotional-health-outcomes-in-adolescence-following-maltreatment-in-early-childhood-a-population-based-study-of-protective-factors
#15
Nisreen Khambati, Liam Mahedy, Jon Heron, Alan Emond
Although childhood maltreatment is associated with long-term impairment, some children function well despite this adversity. This study aimed to identify the key protective factors for good educational attainment and positive emotional health in adolescents who experienced maltreatment in early childhood. Data were analyzed from the Avon Longitudinal Study of Parents and Children, a large UK prospective cohort study. The sample was defined by maternally reported exposure to physical or emotional maltreatment by a parent prior to 5 years...
May 21, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29793147/study-on-the-interactions-between-toxic-nitroanilines-and-lysozyme-by-spectroscopic-approaches-and-molecular-modeling
#16
Yunlan Gu, Yanqing Wang, Hongmei Zhang
Being exogenous environmental pollutants, nitroanilines (NAs) are highly toxic and have mutagenic and carcinogenic activity. Being lack of studies on interactions between NAs and lysozyme at molecular level, the binding interactions of lysozyme with o-nitroaniline (oNA), m-nitroaniline (mNA) and p-nitroaniline (pNA) were investigated by means of steady-state fluorescence, synchronous fluorescence, UV-vis absorption spectroscopy, as well as molecular modeling. The experimental results revealed that the fluorescence of lysozyme is quenched by oNA and mNA through a static quenching, while the fluorescence quenching triggered by pNA is a combined dynamic and static quenching...
May 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29793129/global-mittag-leffler-stability-and-synchronization-analysis-of-fractional-order-quaternion-valued-neural-networks-with-linear-threshold-neurons
#17
Xujun Yang, Chuandong Li, Qiankun Song, Jiyang Chen, Junjian Huang
This paper talks about the stability and synchronization problems of fractional-order quaternion-valued neural networks (FQVNNs) with linear threshold neurons. On account of the non-commutativity of quaternion multiplication resulting from Hamilton rules, the FQVNN models are separated into four real-valued neural network (RVNN) models. Consequently, the dynamic analysis of FQVNNs can be realized by investigating the real-valued ones. Based on the method of M-matrix, the existence and uniqueness of the equilibrium point of the FQVNNs are obtained without detailed proof...
May 4, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29793119/bioaugmentation-potential-of-a-newly-isolated-strain-sphingomonas-sp-njust37-for-the-treatment-of-wastewater-containing-highly-toxic-and-recalcitrant-tricyclazole
#18
Haobo Wu, Jinyou Shen, Xinbai Jiang, Xiaodong Liu, Xiuyun Sun, Jiansheng Li, Weiqing Han, Yang Mu, Lianjun Wang
In order to develop an effective bioaugmentation strategy for the removal of highly toxic and recalcitrant tricyclazole from wastewater, a tricyclazole degrading strain was firstly successfully isolated and identified as Sphingomonas sp. NJUST37. In batch reactors, 100 mg L-1 tricyclazole could be completely removed within 102 h, which was accompanied by significant biomass increase, TOC and COD removal, as well as toxicity reduction. Chromatography analysis and density functional theory simulation indicated that monooxygenation occurred firstly, followed by triazole ring cleavage, decyanation reaction, hydration reaction, deamination, dihydroxylation and final mineralization reaction...
May 19, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29793117/metagenomic-insights-into-the-microbiota-profiles-and-bioaugmentation-mechanism-of-organics-removal-in-coal-gasification-wastewater-in-an-anaerobic-anoxic-oxic-system-by-methanol
#19
Weichao Xu, Yuxiu Zhang, Hongbin Cao, Yuxing Sheng, Haibo Li, Yuping Li, He Zhao, Xuefei Gui
Coal gasification wastewater is a typical high phenol-containing, toxic and refractory industrial wastewater. Here, lab-scale anaerobic-anoxic-oxic system was employed to treat real coal gasification wastewater, and methanol was added to oxic tank as the co-substrate to enhance the removal of refractory organic pollutants. The results showed that the average COD removal in oxic effluent increased from 24.9% to 36.0% by adding methanol, the total phenols concentration decreased from 54.4 to 44.9 mg/L. GC-MS analysis revealed that contents of phenolic components and polycyclic aromatic hydrocarbons (PAHs) were decreased compared to the control and their degradation intermediates were observed...
May 18, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29793116/patterns-of-invasive-growth-in-malignant-gliomas-the-hippocampus-emerges-as-an-invasion-spared-brain-region
#20
Awais A Mughal, Lili Zhang, Artem Fayzullin, Andres Server, Yuping Li, Yingxi Wu, Rainer Glass, Torstein Meling, Iver A Langmoen, Trygve B Leergaard, Einar O Vik-Mo
BACKGROUND: Widespread infiltration of tumor cells into surrounding brain parenchyma is a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor cells throughout the brain. METHODS: We have studied the invasive phenotype of malignant gliomas in two invasive mouse models and patients. Tumor invasion patterns were characterized in a patient-derived xenograft mouse model using brain-wide histological analysis and magnetic resonance (MR) imaging...
May 21, 2018: Neoplasia: An International Journal for Oncology Research
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