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https://www.readbyqxmd.com/read/28749628/circulating-25-hydroxy-vitamin-d-relative-to-vitamin-d-receptor-polymorphism-after-vitamin-d3-supplementation-in-breast-cancer-women-a-randomized-double-blind-controlled-clinical-trial
#1
Houra Mohseni, Seyed Ahmad Hosseini, Reza Amani, Alireza Ekrami, Ahmad Ahmadzadeh, Seyed Mahmoud Latifi
Objective: The influence of vitamin D receptor (VDR) genetic variation on serum 25-hydroxyvitamin D levels [25(OH)D] after vitamin D3 supplementation remains unclear. We aimed to investigate changes of 25(OH)D in a randomized, double-blind, placebo-controlled clinical trial, according to VDR genotype, after provision of vitamin D3 to breast cancer cases for a 2-month period. Methods: Participants were assigned to two treatment arms: placebo (n = 28) and vitamin D3 supplementation (n =28). The supplementation group received 50,000 IU of vitamin D every week for 2 months...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749624/synthesis-characterization-and-evaluation-of-cytotoxic-effects-of-novel-hybrid-steroidal-heterocycles-as-peg-based-nanoparticles
#2
Mervat M Abd Elhalim, Nasser S M Ismail, Shaymaa M M Yahya, Yasmin Y Omar, Ahmed A Abd Rabou, Deena S Lasheen, Mahmoud F Zawrah, Gamal A Elmegeed
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and PEG based nano-size hybrid forms as anticancer agents against three human cell lines: hepatocellular carcinoma cells (HepG2); breast cancer cells (MCF-7); and colon cancer cells (HCT116)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749621/ten-year-outcome-of-different-treatment-modalities-for-squamous-cell-carcinoma-of-oral-cavity
#3
Imjai Chitapanarux, Patrinee Traisathit, Nicha Komolmalai, Sompol Chuachamsai, Pichit Sittitrai, Tienchai Pattarasakulchai, Rak Tananuwat, Donyarat Boonlert, Patumrat Sripan, Anak Iamaroon
Objective: This study reports outcomes of squamous cell carcinoma of oral cavity (SCCOC) patients with different treatment modalities. Materials and Methods: We evaluated the treatment outcomes of 775 newly diagnosed SCCOC patients treated in our hospital between 2001 and 2010. Outcome data were obtained from the medical records. Survival rates were estimated by the Kaplan-Meyer method. Cox-proportional-hazard regression models were used to compare the risk of death among all risk factors. Results: The patients were divided into group 1) surgery ± adjuvant radiotherapy (RT) (n = 323) or group 2) RT ± chemotherapy (CT) for curative intent (n = 315) or group 3) RT/CT for palliative intent (n = 137)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749614/dissecting-the-dynamics-of-trans-generational-immune-priming
#4
Joachim Kurtz, Sophie A O Armitage
The transfer of immunity from mother to offspring is a central way to endow the offspring with increased protection against pathogens. This phenomenon is not only found within the vertebrate domain: in some circumstances, invertebrate mothers can also give their offspring an immune kick-start, which is termed trans-generational immune priming (TGIP). TGIP has been uncovered for a number of invertebrate species, but it is not ubiquitously evident. The reasons for which are not known. In this issue of Molecular Ecology, Tate, Andolfatto, Demuth, and Graham () probe the molecular underpinnings of TGIP in concert with the temporal dynamics of the response in the red flour beetle, Tribolium castaneum, infected with the bacterium Bacillus thuringiensis (Figure )...
August 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28749613/linked-selection-demography-and-the-evolution-of-correlated-genomic-landscapes-in-birds-and-beyond
#5
Reto Burri
Selection has a deep impact on the distribution of genetic diversity and population differentiation along the genome (the genomic landscapes of diversity and differentiation), reducing diversity and elevating differentiation not only at the sites it targets, but also at linked neutral sites. Fuelled by the high-throughput sequencing revolution, these genomic footprints of selection have been extensively exploited over the past decade with the aim to identify genomic regions involved in adaptation and speciation...
August 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28749609/ricochet-pollination-in-senna-fabaceae-petals-deflect-pollen-jets-and-promote-division-of-labour-among-flower-organs
#6
Thiago Amorim, Brigitte Marazzi, Arlete A Soares, Eliana R Forni-Martins, Celli R Muniz, Christian Westerkamp
Naturalists Fritz and Hermann Müller hypothesised that heteranthery often leads to a division of labour into 'feeding' and 'pollinating' stamens; the latter often being as long as the pistil so as to promote successful pollination on the bees' back. In many buzz-pollinated species of Senna, however, the so-called pollinating stamens are short and do not level with the stigma, raising the question of how pollen is shed on the bees' back. Here we explore a mechanism called "ricochet pollination". We test whether division of labour is achieved through the interaction between short lower stamens and strongly concave "deflector petals"...
July 27, 2017: Plant Biology
https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#7
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749597/a-structural-model-of-nitro-porphyrin-dyes-based-on-spectroscopy-and-density-functional-theory
#8
Christopher Farley, Amit Aggarwal, Sunaina Singh, Aaron Dolor, Philip To, Alexander Falber, Maxwell Crossley, Charles Michael Drain
Nitro-porphyrins are an important class of commercial dyes with a range of potential applications. The nitro group is known to dramatically affect the photophysics of the porphyrin, but there are few systematic investigations of the contributing factors. To address this deficiency, we present spectroscopic studies of a series of nitro-porphyrins, accompanied by density functional theory calculations to elucidate their structures. In particular, we explore how the positions of the substituents affect the energy levels and nuclear geometry...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749592/porphyrin-antennas-on-carbon-nanodots-excited-state-energy-and-electron-transduction
#9
Maurizio Prato, Francesca Arcudi, Volker Strauss, Luka Dordevic, Alejandro Cadranel, Dirk Guldi
We report the synthesis and electron donor-acceptor features of a novel nano-hybrid, in which the light harvesting and electron donating properties of a meso-tetraarylporphyrin (TArP) are combined with the electron accepting features of Nitrogen-Doped Carbon Nanodots (NCNDs). In particular, in a ultrafast process (> 1012 s-1), visible light excitation transforms the strongly quenched porphyrin singlet excited states into 225 ps lived charge separated states. On the other hand, ultraviolet light excitation triggers a non-resolvable transduction of singlet excited state energy from the NCNDs to the porphyrins, followed by the same charge separation observed upon visible light excitation...
July 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749589/precisely-assembled-cyclic-gold-nanoparticle-frames-via-2d-polymer-single-crystal-templating
#10
Christopher Yuren Li, Shan Mei, Hao Qi, Tian Zhou
In recent decades, extensive studies have been devoted to assembling nanoparticles (NPs) into various ordered structures to achieve novel optical properties. It however still remains a challenging task to assemble NPs into cyclic one-dimensional (1D) shapes such as rings and frames. In this work, we report a directed assembly method to precisely assemble NPs into well-defined, free-standing frames using polymer single crystals (PSCs) as the template. Preformed poly(ethylene oxide) (PEO) single crystals were used as the template to direct the crystallization of block copolymer (BCP) poly(ethylene oxide)-b-poly(4-vinylpyridine) (PEO-b-P4VP), which directed gold NPs (AuNPs) to form AuNP frames...
July 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749586/patient-decisions-to-receive-secondary-pharmacogenomic-findings-and-development-of-a-multidisciplinary-practice-model-to-integrate-results-into-patient-care
#11
J Kevin Hicks, Amy Shealy, Allison Schreiber, Marissa Coleridge, Ryan Noss, Marvin Natowicz, Rocio Moran, Timothy Moss, Angelika Erwin, Charis Eng
Whole exome sequencing (WES) has the potential of identifying secondary findings that are predictive of poor pharmacotherapy outcomes. The purpose of this study was to investigate patients' wishes regarding the reporting of secondary pharmacogenomic findings. WES results (n = 106 patients) were retrospectively reviewed to determine the number of patients electing to receive secondary pharmacogenomic results. Phenotypes were assigned based on Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28749584/the-aldh21-gene-found-in-lower-plants-and-some-vascular-plants-codes-for-a-nadp-dependent-succinic-semialdehyde-dehydrogenase
#12
Martina Kopečná, Armelle Vigouroux, Jan Vilím, Radka Končitíková, Pierre Briozzo, Eva Hájková, Lenka Jašková, Klaus von Schwartzenberg, Marek Šebela, Solange Moréra, David Kopečný
Lower plant species including some green algae, non-vascular plants (bryophytes) as well as the oldest vascular plants (lycopods) and ferns (monilophytes) possess a unique aldehyde dehydrogenase (ALDH) gene named ALDH21, which is upregulated during dehydration. However, the gene is absent in flowering plants. Here, we show that ALDH21 from the moss Physcomitrella patens codes for a tetrameric NADP(+) -dependent succinic semialdehyde dehydrogenase (SSALDH), which converts succinic semialdehyde, an intermediate of the γ-aminobutyrate (GABA) shunt pathway, into succinate in the cytosol...
July 27, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28749583/chiral-sulfur-functional-groups-as-definers-of-the-chirality-at-the-metal-in-ir-and-rh-half-sandwich-complexes-a-combined-cd-x-ray-study
#13
Miguel A Sierra, Maria C de la Torre, Roberto Fernandez de la Pradilla, Alma Viso, Maria Frutos, Marta G Avello, Marina Velado, Heinz Gornitzka, Catherine Hemmert
Mesoionic carbenes (MIC) derived from triazolium salts containing chiral sulfoxide or sulfoximine functional groups lead to enantiopure chiral-at-metal Ir(III) and Rh(III) half-sandwich complexes, through the sequence MIC complexation-C-H aromatic activation. The process is efficient and totally diastereoselective in the formation of enantiopure five membered metallacycles. The use of the enantiomers of the sulfur chiral groups allows to prepare complexes having opposite configurations at the metal. Complete retention of the configuration at the metal center is observed during the formation of cationic Ir(III) complexes and upon insertion of alkynes into the Ir(III)-C bond, as demonstrated by a combined Circular Dichroism (CD)-X-ray study...
July 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28749563/a-probabilistic-framework-for-risk-analysis-of-widespread-flood-events-a-proof-of-concept-study
#14
Klaus Schneeberger, Matthias Huttenlau, Benjamin Winter, Thomas Steinberger, Stefan Achleitner, Johann Stötter
This article presents a flood risk analysis model that considers the spatially heterogeneous nature of flood events. The basic concept of this approach is to generate a large sample of flood events that can be regarded as temporal extrapolation of flood events. These are combined with cumulative flood impact indicators, such as building damages, to finally derive time series of damages for risk estimation. Therefore, a multivariate modeling procedure that is able to take into account the spatial characteristics of flooding, the regionalization method top-kriging, and three different impact indicators are combined in a model chain...
July 27, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28749550/combined-resistance-and-endurance-training-at-a-moderate-high-intensity-improves-physical-condition-and-quality-of-life-in-liver-transplant-patients
#15
Diego Moya-Nájera, Ángel Moya-Herraiz, Luis Compte-Torrero, David Hervás, Sebastien Borreani, Joaquin Calatayud, Marina Berenguer, Juan C Colado
BACKGROUND: Although currently, moderate and high intensity concurrent physical exercise is prescribed in populations with special needs due to its greater effect on physical condition and health-related quality of life (HRQOL), there are no data in the liver transplantation (LT) setting. AIM: To evaluate changes in maximal strength, aerobic capacity, body composition, liver function, and HRQOL in LT patients after a moderate to high intensity combined resistance-endurance training...
July 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28749533/charmm-force-field-and-molecular-dynamics-simulations-of-protonated-polyethylenimine
#16
Titus Adrian Beu, Alexandra Farcaş
As a gene delivery vector, polyethylenimine (PEI) shows one of the highest transfection efficiencies, while effectively protecting DNA from enzyme degradation. The distinctive charge pattern of protonated PEI is widely considered responsible for fundamental process such as DNA condensation into PEI/DNA polyplexes (which are able to enter cells via endocytosis), proton sponge effect (which triggers the release of polyplexes from endosome), and release of DNA from polyplexes (to be further processed inside the nucleus)...
July 27, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28749524/academic-outcomes-and-cognitive-performance-in-problematic-internet-users
#17
María Marín Vila, José Luis Carballo Crespo, Ainhoa Coloma Carmona
Only few studies have examined the relationship between problematic Internet use (PIU) and cognitive and academic performance in adolescents. The aim of this study was to analyze the differences in academic and cognitive performance (perception, attention, memory, verbal fluency and abstract reasoning) between adolescents with and without PIU. A total of 575 students from different high schools of the region of Alicante participated. Students were divided into two groups: adolescents with and without PIU (PIU and NPIU, respectively)...
July 13, 2017: Adicciones
https://www.readbyqxmd.com/read/28749520/photocurrent-spectroscopy-of-dye-sensitized-carbon-nanotubes
#18
Asiful Alam, Simone Dehm, Frank Hennrich, Yuriy Zakharko, Arko Graf, Moritz Pfohl, Ihteaz M Hossain, Manfred M Kappes, Jana Zaumseil, Ralph Krupke, Benjamin S Flavel
Monochiral (7,5) single walled carbon nanotubes (SWCNTs) are integrated into a field effect transistor device in which the built-in electric field at the nanotube/metal contact allows for exciton separation under illumination. Variable wavelength spectroscopy and 2D surface mapping of devices consisting of 10-20 nanotubes are performed in the visible region and a strong correlation between the nanotube's second optical transition (S22) and the photocurrent is found. After integration, the SWCNTs are non-covalently modified with three different fluorescent dye molecules with off-resonant absorption maxima at 532 nm, 565 nm, and 610 nm...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749517/synthesis-of-3-acylindoles-by-oxidative-rearrangement-of-2-aminochalcones-using-a-hypervalent-iodine-reagent-and-cyclization-sequence
#19
Akira Nakamura, Satoshi Tanaka, Akira Imamiya, Reo Takane, Chiaki Ohta, Kazuma Fujimura, Tomohiro Maegawa, Yasuyoshi Miki
An efficient one-pot method was developed for the construction of 3-acylindoles via oxidative rearrangement of 2-aminochalcones followed by intramolecular cyclization. The reaction was used to convert a variety of 2-aminochalcones into 3-acylindoles in moderate to high yields.
July 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28749508/linking-hygroscopicity-and-the-surface-microstructure-of-model-inorganic-salts-simple-and-complex-carbohydrates-and-authentic-sea-spray-aerosol-particles
#20
Armando D Estillore, Holly S Morris, Victor W Or, Hansol D Lee, Michael R Alves, Meagan A Marciano, Olga Laskina, Zhen Qin, Alexei V Tivanski, Vicki H Grassian
Individual airborne sea spray aerosol (SSA) particles show diversity in their morphologies and water uptake properties that are highly dependent on the biological, chemical, and physical processes within the sea subsurface and the sea surface microlayer. In this study, hygroscopicity data for model systems of organic compounds of marine origin mixed with NaCl are compared to data for authentic SSA samples collected in an ocean-atmosphere facility providing insights into the SSA particle growth, phase transitions and interactions with water vapor in the atmosphere...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
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