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Mitochondria reproduction

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https://www.readbyqxmd.com/read/29785746/systematic-in-depth-proteomic-analysis-of-mitochondria-associated-endoplasmic-reticulum-membranes-mam-in-mouse-and-human-testes
#1
Xiaoli Wang, Yujiao Wen, Juan Dong, Congcong Cao, Shuiqiao Yuan
Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate important cellular functions including calcium signaling, bioenergetics, and apoptosis during neurodevelopment and carcinogenesis, but its function in male reproduction and spermatogenesis remains enigmatic because the field lacks a complete understanding of the proteome within testis MAMs. To better understand the biological processes and molecular functions of MAM in testes, here, we report a global mass spectrometry-based proteomic evaluation of the MAM obtained from human testes, mouse testes and brains, respectively...
May 21, 2018: Proteomics
https://www.readbyqxmd.com/read/29778389/resveratrol-improves-in-vitro-maturation-of-oocytes-in-aged-mice-and-humans
#2
Mei-Ju Liu, Ai-Gang Sun, Shi-Gang Zhao, Hui Liu, Shui-Ying Ma, Mei Li, Ying-Xue Huai, Han Zhao, Hong-Bin Liu
OBJECTIVE: To evaluate the effects of resveratrol on oocyte maturation in aged mice and humans. DESIGN: Experimental laboratory study. SETTING: University-based reproductive medicine center. PATIENT(S): A total of 64 women 38-45 years of age undergoing intracytoplasmic sperm injection (ICSI) and 48-52-week-old female C57BL/6J mice. INTERVENTION(S): In vitro culture in the presence of three different concentrations of resveratrol (0...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29767280/carnosine-and-histidine-supplementation-blunt-lead-induced-reproductive-toxicity-through-antioxidative-and-mitochondria-dependent-mechanisms
#3
Mohammad Mehdi Ommati, Akram Jamshidzadeh, Reza Heidari, Zilong Sun, Mohammad Javad Zamiri, Forouzan Khodaei, Saeed Mousapour, Fatemeh Ahmadi, Nafiseh Javanmard, Babak Shirazi Yeganeh
Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced reproductive toxicity is associated with increased reactive oxygen species (ROS) formation and diminished antioxidant capacity in the reproductive system. Hence, administration of antioxidants as protective agents might be of value against Pb-induced reproductive toxicity...
May 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29764546/-effect-of-pyrrolidine-dithiocarbamate-on-oxidative-stress-and-mitochondrial-function-of-lung-tissue-in-mice-with-acute-lung-injury
#4
Hongfu Yang, Ke Chao, Ming Liang, Rongqing Sun
OBJECTIVE: To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on oxidative stress and mitochondrial function of lung tissue in mice with acute lung injury (ALI) induced by lipopolysaccharide (LPS). METHODS: Forty female Balb/c mice were randomly divided into normal saline (NS) control group, LPS model group, PDTC group, and PDTC+LPS group, with 10 mice in each group. The model of mice with ALI was reproduced by intraperitoneal injection of 15 mg/kg LPS...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29710643/pm-2-5-induces-male-reproductive-toxicity-via-mitochondrial-dysfunction-dna-damage-and-ripk1-mediated-apoptotic-signaling-pathway
#5
Jin Zhang, Jianhui Liu, Lihua Ren, Jialiu Wei, Junchao Duan, Lefeng Zhang, Xianqing Zhou, Zhiwei Sun
Recent years, air pollution has been a serious problem, and PM2.5 is the main air particulate pollutant. Studies have investigated that PM2.5 is a risky factor to the deterioration of semen quality in males. But, the related mechanism is still unclear. To explore the effect of PM2.5 , Sprague Dawley (SD) rats were exposed to PM2.5 (0, 1.8, 5.4 and 16.2mg/kg.bw.) through intratracheal instillation. The exposure was performed once every 3days and continued for 30days. In vitro, GC-2spd cells were treated using 0, 50, 100, 200μg/mL PM2...
September 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29706148/fluoxetine-treatment-of-prepubertal-male-rats-uniformly-diminishes-sex-hormone-levels-and-in-a-subpopulation-of-animals-negatively-affects-sperm-quality
#6
María E Ayala, Ayari Gonzáles, Rodrigo M Olivarez, Andrés Aragón-Martínez
Fluoxetine (Flx) is a selective serotonin reuptake inhibitor that alters the male reproductive system when administered at the adult stage or after maternal exposure. In the present study we evaluated the effects of Flx administration on reproductive parameters during juvenile-peripubertal development when treated male rats reached adulthood. Groups of rats were treated daily with Flx (5mgkg-1, i.p.) or saline (0.9% NaCl), or were left untreated. Rats were treated between 30 and 53 days of age and were killed at 65 days of age...
April 30, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29691935/mitochondria-and-wolbachia-titers-are-positively-correlated-during-maternal-transmission
#7
Lucas P Henry, Irene L G Newton
Mothers provide their offspring with symbionts. Maternally transmitted, intracellular symbionts must disperse from mother to offspring with other cytoplasmic elements, like mitochondria. Here, we investigated how the intracellular symbiont Wolbachia interacts with mitochondria during maternal transmission. Mitochondria and Wolbachia may interact antagonistically and compete as each population tries to ensure its own evolutionary success. Alternatively, mitochondria and Wolbachia may cooperate as both benefit from ensuring the fitness of the mother...
April 25, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29688061/molecular-activities-and-ligand-binding-specificities-of-star-related-lipid-transfer-domains-exploring-integrated-in-silico-methods-and-ensemble-docking-approaches
#8
K Kranthi Kumar, B Uma Devi, P Neeraja
In this study, cholesterol biotransformation gene-set of human steroidogenic acute regulatory protein-related lipid transfer (START) domains were evaluated from high-throughput gene screening approaches. It was shown that STARD1, STARD3 and STARD4 proteins are better effective transporters of cholesterol than STARD5 and STARD6 domains. Docking studies show a strong agreement with gene ontology enrichment data. According to both complementary strategies, it was found that only STARD1, STARD3 and STARD4 are potentially involved in cholesterol biotransformation in mitochondria through Ω1-loop of C-terminal α4-helical domain...
April 24, 2018: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29619606/the-role-of-reactive-oxygen-species-in-pollen-germination-in-picea-pungens-blue-spruce
#9
Nikita Maksimov, Anastasia Evmenyeva, Maria Breygina, Igor Yermakov
Endogenous ROS, including those produced by NADPH oxidase, are required for spruce pollen germination and regulate membrane potential in pollen tubes; [Formula: see text] and H2 O2 are unevenly distributed along the tube. Recently, the key role of reactive oxygen species (ROS) in plant reproduction has been decisively demonstrated for angiosperms. This paper is dedicated to the involvement of ROS in pollen germination of gymnosperms, which remained largely unknown. We found that ROS are secreted from pollen grains of blue spruce during the early stage of activation...
April 4, 2018: Plant Reproduction
https://www.readbyqxmd.com/read/29604142/irradiation-of-semen-doses-with-led-based-red-light-in-a-photo-chamber-does-not-improve-in-vitro-quality-of-thermically-stressed-boar-spermatozoa
#10
A Luther, X Le Thi, J Schäfer, M Schulze, D Waberski
Recent reports indicate that stimulation of liquid-stored boar semen with red LED-based light improves sperm quality and reproductive performance in sow herds. So far, in vitro data after LED stimulation of whole semen doses are lacking. In this study, the effect of LED light exposure on the in vitro quality of boar spermatozoa after storage and thermic incubation was examined. Boar semen doses were stored at 17°C (n = 10) or 5°C (n = 6) in Beltsville Thawing Solution extender and then exposed to red LED light using a commercial photo chamber...
March 31, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29602044/effects-of-environmentally-relevant-sub-chronic-atrazine-concentrations-on-african-clawed-frog-xenopus-laevis-survival-growth-and-male-gonad-development
#11
Cornelius Rimayi, David Odusanya, Jana M Weiss, Jacob de Boer, Luke Chimuka, Felix Mbajiorgu
Sub-chronic toxicity of environmentally relevant atrazine concentrations on exposed tadpoles and adult male African clawed frogs (Xenopus laevis) was evaluated in a quality controlled laboratory for 90 days. The aim of this study was to determine the effects of atrazine on the survival, growth and gonad development of African clawed frogs. After exposure of tadpoles to atrazine concentrations of 0 (control), 0.01, 200 and 500 μg L-1 in water, mortality rates of 0, 0, 3.3 and 70% respectively were recorded for the 90 day exposure period...
March 23, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29601598/outer-membrane-vesicles-from-neisseria-gonorrhoeae-target-porb-to-mitochondria-and-induce-apoptosis
#12
Pankaj Deo, Seong H Chow, Iain D Hay, Oded Kleifeld, Adam Costin, Kirstin D Elgass, Jhih-Hang Jiang, Georg Ramm, Kipros Gabriel, Gordon Dougan, Trevor Lithgow, Eva Heinz, Thomas Naderer
Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea by evading innate immunity. Colonizing the mucosa of the reproductive tract depends on the bacterial outer membrane porin, PorB, which is essential for ion and nutrient uptake. PorB is also targeted to host mitochondria and regulates apoptosis pathways to promote infections. How PorB traffics from the outer membrane of N. gonorrhoeae to mitochondria and whether it modulates innate immune cells, such as macrophages, remains unclear. Here, we show that N...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29598846/the-role-of-mitochondrial-activity-in-female-fertility-and-assisted-reproductive-technologies-overview-and-current-insights
#13
REVIEW
Gustavo Nardini Cecchino, Emre Seli, Eduardo Leme Alves da Motta, Juan Antonio García-Velasco
Mitochondria have been implicated as key factors regulating female reproductive processes. Notable progress has been made in determining the role of mitochondria with respect to oocyte maturation, fertilization and early embryo development. In addition, mitochondrial function and dysfunction has been the subject of various studies in ovarian ageing and metabolic stress models. However, the overall mitochondrial impact on female fertility is yet to be uncovered. The mitochondrial DNA content of granulosa, cumulus and trophectoderm cells is being explored as a biomarker of oocyte quality and embryo viability...
March 8, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29581388/maternal-inheritance-of-mitochondria-implications-for-male-fertility
#14
REVIEW
R C Vaught, D K Dowling
Evolutionary theory predicts maternal inheritance of the mitochondria will lead to the accumulation of mutations in the mitochondrial DNA (mtDNA) that impair male fertility, but leave females unaffected. The hypothesis has been referred to as 'Mother's Curse'. There are many examples of mtDNA mutations or haplotypes, in humans and other metazoans, associated with decreases in sperm performance, but seemingly few reports of associations involving female reproductive traits; an observation that has been used to support the Mother's Curse hypothesis...
April 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29575225/peanut-agglutinin-specifically-binds-to-a-sperm-region-between-the-nucleus-and-mitochondria-in-tunicates-and-sea-urchins
#15
Shiori Nakazawa, Maki Shirae-Kurabayashi, Hitoshi Sawada
Peanut agglutinin (PNA) is an established marker of the mammalian acrosome. However, we observed that PNA specifically binds to a unique intracellular structure alongside the nucleus in ascidian sperm. Here, we characterize the PNA-binding structure in sperm of marine invertebrates. PNA bound to the region between the mitochondrion and nucleus in spermatozoa of ascidians, sea urchins, and an appendicularian. However, PNA-binding substances were not exposed by the calcium ionophore ionomycin in three ascidian species, indicating that it is a distinct structure from the acrosome...
March 25, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29574012/protection-of-cyanidin-3-o-glucoside-against-acrylamide-and-glycidamide-induced-reproductive-toxicity-in-leydig-cells
#16
Jianxia Sun, Mingwei Li, Feiyan Zou, Shun Bai, Xinwei Jiang, Lingmin Tian, Shiyi Ou, Rui Jiao, Weibin Bai
Acrylamide (AA) occurs in many cooked carbohydrate-rich foods and has caused widespread concern as a possible carcinogen. Glycidamide (GA) is the ultimate genotoxic metabolite of AA. The present study was to investigate the protective effect of Cyanidin-3-O-glucoside (C3G) against AA- and GA-induced reproductive toxicity in R2C Leydig cells. The results demonstrated that C3G inhibited AA- and GA-induced cytotoxicity and mitochondria-mediated cell apoptosis, the effective doses of C3G were ranging from 10 to 50 μM...
March 21, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29552281/dehydroepiandrosterone-induced-activation-of-mtorc1-and-inhibition-of-autophagy-contribute-to-skeletal-muscle-insulin-resistance-in-a-mouse-model-of-polycystic-ovary-syndrome
#17
Xi Song, Qiyang Shen, Liting Fan, Qiuxiao Yu, Xiao Jia, Yu Sun, Wenpei Bai, Jihong Kang
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and also an important metabolic disorder associated with insulin resistance (IR). Hyperandrogenism is a key feature of PCOS. However, whether hyperandrogenism can cause IR in PCOS remains largely unknown. The mammalian target of rapamycin complex 1 (mTORC1) and its regulated autophagy are closely associated with IR. In the present study, we investigated the role of mTORC1-autophagy pathway in skeletal muscle IR in a dehydroepiandrosterone (DHEA)-induced PCOS mouse model...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29546367/the-molecular-characterisation-of-mitochondrial-dna-deficient-oocytes-using-a-pig-model
#18
Te-Sha Tsai, Sonika Tyagi, Justin C St John
STUDY QUESTION: What are the molecular differences between mitochondrial DNA (mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial supplementation alter these? SUMMARY ANSWER: Changes to DNA methylation in a 5' cytosine-phosphate-guanine 3' (CpG) island in the mtDNA-specific replication factor (DNA polymerase gamma (POLG)) of mtDNA-deficient oocytes mediates an increase in mtDNA copy number by the 2-cell stage that positively modulates the expression of nuclear genes, which affect cellular and metabolic processes, following autologous mitochondrial supplementation...
May 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29533769/did-mitochondria-kill-the-frog
#19
COMMENT
Souhir Marsit, Anne-Marie Dion-Côté, Daniel A Barbash
Genomic divergence can cause reproductive isolation between species. The molecular mechanisms underlying reproductive isolation can thus reveal which genomic features evolve rapidly and become unstable or incompatible in hybrids. In a recent paper in Nature, Gibeaux et al. (2018) report paternal genome instability and metabolic imbalance in hybrids between frog species.
March 12, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29487162/high-activity-before-breeding-improves-reproductive-performance-by-enhancing-mitochondrial-function-and-biogenesis
#20
Yufeng Zhang, Adam L Brasher, Noel R Park, Halie A Taylor, Andreas N Kavazis, Wendy R Hood
Understanding of physiological responses of organisms is typically based on data collected during an isolated event. Although many fundamental insights have been gained from these studies, evaluating the response to a single event ignores the fact that each individual has experienced a unique set of events throughout its life that may have altered its physiology. The idea that prior experiences can influence subsequent performance is known as a carry-over effect. Carry-over effects may explain much of the variation in performance found among individuals...
April 6, 2018: Journal of Experimental Biology
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