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https://www.readbyqxmd.com/read/28730646/prospective-observational-study-of-carbon-ion-radiotherapy-for-non-squamous-cell-carcinoma-of-the-head-and-neck
#1
Katsuyuki Shirai, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Daijiro Kobayashi, Takeo Takahashi, Tomoaki Tamaki, Hidemasa Kawamura, Yukihiro Takayasu, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Junko Hirato, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck. Thirty-five patients were enrolled in this prospective study. The primary endpoint was the 3-year local control rate, while secondary endpoints included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and 3 patients received 64...
July 21, 2017: Cancer Science
https://www.readbyqxmd.com/read/28730226/histopathological-aspects-of-some-rare-forms-of-facial-basal-cell-carcinoma
#2
Răzvan MercuŢ, Sandy Dast, Marius Eugen Ciurea, Claudiu Mărgăritescu, Florin Dan Popescu, Horia Octavian Manolea, Monica Scrieciu, Ştefan Mugurel Ghelase
AIM: The main objective of the study was to highlight the histopathological aspects of some rare forms of facial basal cell carcinomas. PATIENTS, MATERIALS AND METHODS: The 65 selected patients were diagnosed with head basal cell carcinoma (BCC), during 2011-2013, and they underwent surgery. The excised tumor tissue fragments were processed for paraffin embedding and stained with Hematoxylin-Eosin (HE), Masson's trichrome with Aniline Blue, and Alcian Blue-Periodic Acid Schiff (AB-PAS)...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28728749/numb-chin-with-mandibular-pain-or-masticatory-weakness-as-indicator-for-systemic-malignancy-a-case-series-study
#3
Shin-Yu Lu, Shu-Hua Huang, Yen-Hao Chen
BACKGROUND/PURPOSE: Numb chin syndrome (NCS) is a critical sign of systemic malignancy; however it remains largely unknown by clinicians and dentists. The aim of this study was to investigate NCS that is more often associated with metastatic cancers than with benign diseases. METHODS: Sixteen patients with NCS were diagnosed and treated. The oral and radiographic manifestations were assessed. RESULTS: Four (25%) of 16 patients with NCS were affected by nonmalignant diseases (19% by medication-related osteonecrosis of the jaw and 6% by osteopetrosis); yet 12 (75%) patient conditions were caused by malignant metastasis, either in the mandible (62%) or intracranial invasion (13%)...
July 17, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28727172/immunohistochemical-expression-of-myb-in-salivary-gland-basal-cell-adenocarcinoma-and-basal-cell-adenoma
#4
Sydney L Rooney, Robert A Robinson
BACKGROUND: Basal cell predominant salivary gland neoplasms can be difficult to separate histologically. One of the most aggressive of basaloid salivary gland neoplasms is adenoid cystic carcinoma. MYB expression by immunohistochemistry has been documented in adenoid cystic carcinoma. Some investigators have suggested that using this expression can help in the establishing the diagnosis of adenoid cystic carcinoma. Utilizing tissue microarrays, we studied a group of basal cell adenocarcinomas and basal cell adenomas to determine: 1) if either tumor expressed MYB, and 2) the frequency of any expression in either...
July 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28719465/predictors-of-outcome-in-adenoid-cystic-carcinoma-of-salivary-glands-a-clinicopathologic-study-with-correlation-between-myb-fusion-and-protein-expression
#5
Bin Xu, Esther Drill, Allen Ho, Alan Ho, Lara Dunn, Carlos Nicolas Prieto-Granada, Timothy Chan, Ian Ganly, Ronald Ghossein, Nora Katabi
Adenoid cystic carcinoma (ACC) is the second most common salivary gland malignancy and it has a high rate of recurrences and a poor long-term prognosis. Our aim was to assess the prognostic factors in ACC and study MYB-NFIB fusion and MYB protein expression in a large retrospective cohort of 135 patients with a median follow-up of 6.3 years. The 5- and 10-year local recurrence-free survival (RFS) rate of 94% and 78%, 5- and 10-year distant metastasis survival rate of 77% and 58%, and 5- and 10-year RFS of 66% and 44%...
July 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28713756/dental-invasion-by-adenoid-cystic-carcinoma-of-the-oral-cavity
#6
Marco Guzzo, Pasquale Quattrone, Roberto Bianchi, Sarah Colombo
Cancer progression through the mandible bone is still questioned. Once the tumor has eroded the cortex, it can extend vertically and laterally. It usually spreads in the medullary spaces and finally affects the alveolar nerve. The presence of the teeth has been considered as a relative barrier to cancer infiltration until now. Herein, we report an uncommon case of dental root invasion by adenoid cystic carcinoma of the floor of the mouth.
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28702869/ambulatory-clinical-parameters-and-sleep-respiratory-events-in-a-group-of-obese-children-unselected-for-respiratory-problems
#7
Marco Zaffanello, Giorgio Piacentini, Angelo Pietrobelli, Cristiano Fava, Giuseppe Lippi, Claudio Maffeis, Emma Gasperi, Luana Nosetti, Sara Bonafini, Angela Tagetti, Franco Antoniazzi
BACKGROUND: Obstructive sleep apnea in children is frequently due to tonsil and adenoid hypertrophy. This study aimed to investigate the relationship between ambulatory clinical parameters and sleep respiratory events in obese children. METHODS: We carried out a prospective respiratory sleep study between 2013 and 2015. Nails obstruction, tonsils enlargement and palate position were subjectively measured. Italian attention deficit hyperactivity disorder (ADHD) rating scale for parents was also performed...
July 12, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28700564/long-term-effects-of-adenotonsillectomy-on-serum-specific-immunoglobulin-e
#8
Lijuan Song, Jinfei Guo, Wenjing Liao, Peichang Ye, Li Liu, Tao Chen, Pingchang Yang, Nanshan Zhong, Baoqing Sun, Xiaowen Zhang
BACKGROUND: The biased immune reactions of the adenotonsillar tissues are not always reflected by the serum IgE; thus, we hypothesize that the systemic atopic status may not be changed after the adenotonsillectomy (AT) in children. METHODS: Twenty-five with AT and 23 age-matched healthy childrenwere enrolled into this study, followed-up approximately 4 years. Nasal Symptoms Scores (NSS), Quality of Life Scores (QOLS), specific IgE (sIgE), cytokines, and inflammatory cell were documented in all the subjects before and after study...
July 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28692517/resection-of-adenoid-cystic-carcinoma-originating-from-the-cavernous-sinus-via-endoscopic-endonasal-approach
#9
Jingpu Yang, Wei Zhong, Jinzhang Cheng, Zhuping Zhang, Song Li, Zonggui Wang
A 50-year-old woman presented with gradually increasing right-sided facial numbness. Neuroimaging revealed a lesion in the right cavernous sinus mimicking meningioma. The resection of the right cavernous sinus neoplasm was implemented via endoscopic endonasal approach under general anesthesia. Histological examination of the surgical specimen revealed adenoid cystic carcinoma. Adenoid cystic carcinoma in the cavernous sinus is extremely rare as a primary lesion and challenging to manage. Little data exist to guide treatment when this tumor extends to involve the structure of cavernous sinus...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28692497/the-safety-and-accuracy-of-surgical-navigation-technology-in-the-treatment-of-lesions-involving-the-skull-base
#10
Bin Wei, Guowen Sun, Qingang Hu, Enyi Tang
OBJECTIVE: As compared with the normal anatomy, structures of the skull base and its surroundings have been dramatically altered of the lesion near the skull base. How to remove the lesion at the skull base was mainly depending on surgeon's personal experience during past years. In this study, the authors explored the safety and accuracy of the surgical navigation system in resecting lesions near the skull base. METHODS: The surgical cases consisted of 15 patients who underwent surgery involving the skull base with the using of surgical navigation technology...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28691830/the-effect-of-adenotomy-allergy-and-smoking-on-microbial-colonization-of-upper-aerodigestive-tract-in-children
#11
B Uhliarová, G Bugová, M Jeseňák, S Pechacova, M Hamarova, A Hajtman
AIM: To evaluate microbial colonization of upper aerodigestive tract in children and to investigate the influence of adenoid hypertrophy, allergy and exposition to cigarette smoke on presence of pathogens. METHODS: In 43 children with adenoid hypertrophy and 17 healthy children bacterial culture was performed by a swab from middle nasal meatus, nasopharynx and tonsils. The effect of adenotomy, presence of allergy and exposure to passive smoking on bacterial colonization were investigated...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28690230/-comparison-between-the-effect-of-endoscopic-assisted-low-temperature-plasma-and-electric-planer-on-the-treatment-of-adenoid-hypertrophy-a-meta-analysis
#12
Shaobing Xie, Yanni Zhang, Zhenhang Xu, Jianhui Zhang, Xuewen Wu, Hong Sun
To compare the effect of endoscopic-assisted low temperature plasma (ELTP) and electric planer (EP) on the treatment of adenoid hypertrophy.
 Methods: We searched China National Knowledge Infrastructure (CNKI), Wanfang Database, Weipu Database, Chinese Biomedical Literature (CMB), PubMed, Embase, Cochrane Database, and collected the randomized controlled studies regarding the effect of ELTP and EP on the treatment of adenoid hypertrophy from January 2007 to June 2016. Methodologies were used to evaluate the included studies, and Meta-analysis was performed by Revman 5...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28675019/-inhibitory-effect-and-underlying-mechanism-of-total-saponins-from-paris-polyphylla-var-yunnanensis-on-the-proliferation-of-salivary-adenoid-cystic-carcinoma-acc-83-cells
#13
He Qiumin, Xu Biao, Wang Weihong, Bao Chongyun, Hu Shaowei
OBJECTIVE: To investigate the inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells. METHODS: In vitro cell culture was performed. The proliferation of ACC-83 cells treated with different concentrations (5, 10, 20, 40, 60, 80, 100 μg·mL⁻¹) of total saponins from Paris polyphylla var. yunnanensis was observed using CCK-8 assay. Meanwhile, the apoptosis of ACC-83 cells treated with different concentrations (25, 50, 100 μg·mL⁻¹) of the total saponins was observed using flow cytometry...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28671620/epithelial-to-mesenchymal-transition-in-the-pathogenesis-and-therapy-of-head-and-neck-cancer
#14
REVIEW
Julia Thierauf, Johannes Adrian Veit, Jochen Hess
Head and neck cancer (HNC) is one of the most prevalent human malignancies worldwide, with a high morbidity and mortality. Implementation of interdisciplinary treatment modalities has improved the quality of life, but only minor changes in overall survival have been achieved over the past decades. Main causes for treatment failure are an aggressive and invasive tumor growth in combination with a high degree of intrinsic or acquired treatment resistance. A subset of tumor cells gain these properties during malignant progression by reactivating a complex program of epithelia-to-mesenchymal transition (EMT), which is integral in embryonic development, wound healing, and stem cell behavior...
July 3, 2017: Cancers
https://www.readbyqxmd.com/read/28669965/-clinical-features-of-advanced-adenoid-cystic-carcinoma-in-the-nasal-cavity-and-paranasal-sinuses-analysis-of-21-cases
#15
Hui-Gang Wang, Cong-Xiang Shen, Fang Chen, Guan-Xue Li, Xiao-Qi Wang, Zhong Wen
OBJECTIVE: To evaluate the clinical characteristics, treatment and prognosis of advanced adenoid cystic carcinoma (ACC) in the nasal cavity and paranasal sinuses. METHODS: Twenty-one patients with advanced ACC in the nasal cavity and paranasal sinuses were treated in our department between February, 2007 and May, 2016. The clinical manifestations, T-stage, N-status, treatment, histological grade, recurrence and distant metastasis of the tumors were analyzed. Univariate survival analysis was performed with Kaplan-Meier method and Log-rank test, and the factors affecting the prognosis of the patients were explored using multivariate analysis with Cox proportional hazard model...
June 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28668836/microrna-profiling-and-target-genes-related-to-metastasis-of-salivary-adenoid-cystic-carcinoma
#16
Xin Feng, Kyle Matsuo, Tan Zhang, Yunping Hu, Ashley C Mays, James D Browne, Xiaobo Zhou, Christopher A Sullivan
BACKGROUND/AIM: Perineural invasion and distant metastasis lead to a poor prognosis of adenoid cystic carcinoma and there is no effective therapy available. MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression, which can be biomarkers or therapeutic targets for certain cancer types. We aimed to identify miRNAs and their target genes possibly involved in metastasis of salivary gland adenoid cystic carcinoma (SACC). MATERIALS AND METHODS: Using Nanostring nCounter analysis, we examined miRNA expression in two SACC cell lines: SACC-83 and SACC-LM, with low and high lung metastasis rates, respectively...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28668494/lung-metastasis-in-primary-cutaneous-adenoid-cystic-carcinoma-clinicopathological-evaluation-of-a-rare-case-with-review-of-literature
#17
Gunjesh Kumar Singh, Pragya Singh, Jaspreet Kaur, Rakesh Kumar
Primary cutaneous adenoid cystic carcinoma (ACC) is an extremely rare and indolent cutaneous malignancy with very infrequent distant metastasis. We present a case of primary cutaneous ACC with bilateral lung metastases in a 57-year-old male along with literature review. To the best of our knowledge this is the tenth case of primary cutaneous ACC reported presenting with distant metastasis.
June 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28664668/human-papillomavirus-related-carcinoma-with-adenoid-cystic-like-features-a-series-of-5-cases-expanding-the-pathologic-spectrum
#18
Jen-Fan Hang, Min-Shu Hsieh, Wing-Yin Li, Jo-Yu Chen, Shih-Yao Lin, Shih-Hao Liu, Chin-Chen Pan, Ying-Ju Kuo
AIMS: Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a newly described entity of the sinonasal tract. In this study, we evaluated histomorphology, immunophenotype, and molecular testing to identify potentially helpful features in distinguishing it from classical adenoid cystic carcinoma (AdCC). METHODS AND RESULTS: We retrospectively collected 5 HPV-related carcinomas with adenoid cystic-like features and 14 AdCCs of the sinonasal tract...
June 30, 2017: Histopathology
https://www.readbyqxmd.com/read/28659312/radiosensitization-of-adenoid-cystic-carcinoma-with-mdm2-inhibition
#19
Prashanth J Prabakaran, Amal M Javaid, Adam D Swick, Lauryn R Werner, Kwangok P Nickel, Emmanuel Sampene, Rong Hu, Irene M Ong, Justine Y Bruce, Gregory K Hartig, Aaron Wieland, Jude Canon, Paul M Harari, Randall J Kimple
Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and neck. There are currently no approved systemic agents or known radiosensitizers for ACC. Unlike the more common head and neck squamous cell carcinomas that frequently harbor TP53 mutations, ACC contain TP53 mutations at a rate of <5%, rendering them an attractive target for MDM2 inhibition. <p>Experimental Design: We report the successful establishment and detailed characterization of a TP53-WT ACC patient derived xenograft (PDX) which retained the histologic features of the original patient tumor...
June 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28655435/primary-epithelial-salivary-gland-tumours-in-children-and-adolescents
#20
M Gontarz, G Wyszyńska-Pawelec, J Zapała
Primary epithelial tumours of the salivary glands are very rare in paediatric patients. The aim of this study was to evaluate the clinical course, treatment, and outcomes of these uncommon neoplasms based on the authors' experience and the recent literature. The medical charts of 12 female patients and seven male patients with primary epithelial salivary gland tumours were reviewed. All were under 19 years of age and underwent surgical treatment between 1994 and 2016. The results of this group of paediatric patients were compared with those of 621 adult patients...
June 24, 2017: International Journal of Oral and Maxillofacial Surgery
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