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Chronic traumatic encephalopathy

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https://www.readbyqxmd.com/read/29321231/chronic-traumatic-encephalopathy-in-an-epilepsy-surgery-cohort-clinical-and-pathologic-findings
#1
Amy L Jones, Jeffrey W Britton, Melissa M Blessing, Joseph E Parisi, Gregory D Cascino
OBJECTIVE: To determine the occurrence of chronic traumatic encephalopathy (CTE) in young adult patients undergoing epilepsy surgery. METHODS: Ten patients who underwent epilepsy surgery were randomly selected for this retrospective study. The patients were 18-45 years of age, had preoperative neuropsychological evaluation, and had 1 year postoperative follow-up. Microscopic sections from resections were evaluated for the presence of CTE with standard stains and antibodies to tau (clone AT8)...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29310134/chief-concern-i-m-worried-i-have-chronic-traumatic-encephalopathy
#2
David L Brody
No abstract text is available yet for this article.
January 9, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29298849/pathologic-thr175-tau-phosphorylation-in-cte-and-cte-with-als
#3
Alexander J Moszczynski, Wendy Strong, Kathy Xu, Ann McKee, Arthur Brown, Michael J Strong
OBJECTIVE: To investigate whether chronic traumatic encephalopathy (CTE) and CTE with amyotrophic lateral sclerosis (CTE-ALS) exhibit features previously observed in other tauopathies of pathologic phosphorylation of microtubule-associated protein tau at Thr175 (pThr175 tau) and Thr231 (pThr231 tau), and glycogen synthase kinase-3β (GSK3β) activation, and whether these pathologic features are a consequence of traumatic brain injury (TBI). METHODS: Tau isoform expression was assayed by western blot in 6 stage III CTE cases...
January 3, 2018: Neurology
https://www.readbyqxmd.com/read/29276758/role-of-tau-acetylation-in-alzheimer-s-disease-and-chronic-traumatic-encephalopathy-the-way-forward-for-successful-treatment
#4
Brandon Lucke-Wold, Kay Seidel, Rub Udo, Bennet Omalu, Mark Ornstein, Richard Nolan, Charles Rosen, Joel Ross
Progressive neurodegenerative diseases plague millions of individuals both in the United States and across the world. The current pathology of progressive neurodegenerative tauopathies, such as Alzheimer's disease (AD), Pick's disease, frontotemporal dementia (FTD), and progressive supranuclear palsy, primarily revolves around phosphorylation and hyperphosphorylation of the tau protein. However, more recent evidence suggests acetylation of tau protein at lysine 280 may be a critical step in molecular pathology of these neurodegenerative diseases prior to the tau hyperphosphorylation...
2017: Journal of Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29260223/chronic-traumatic-encephalopathy-in-football-players-reply
#5
LETTER
Ann C McKee, Jesse Mez, Bobak Abdolmohammadi
No abstract text is available yet for this article.
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29260221/chronic-traumatic-encephalopathy-in-football-players
#6
LETTER
Niloofar Yari
No abstract text is available yet for this article.
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29260220/chronic-traumatic-encephalopathy-in-football-players
#7
LETTER
Scott L Zuckerman, Benjamin L Brett, Aaron M Yengo-Kahn
No abstract text is available yet for this article.
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29257064/a-proposed-mechanism-for-development-of-cte-following-concussive-events-head-impact-water-hammer-injury-neurofilament-release-and-autoimmune-processes
#8
Steven Kornguth, Neal Rutledge, Gabe Perlaza, James Bray, Allen Hardin
During the past decade, there has been an increasing interest in early diagnosis and treatment of traumatic brain injuries (TBI) that lead to chronic traumatic encephalopathy (CTE). The subjects involved range from soldiers exposed to concussive injuries from improvised explosive devices (IEDs) to a significant number of athletes involved in repetitive high force impacts. Although the forces from IEDs are much greater by a magnitude than those from contact sports, the higher frequency associated with contact sports allows for more controlled assessment of the mechanism of action...
December 19, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29213517/soccer-football-association-and-chronic-traumatic-encephalopathy-a-short-review-and-recommendation
#9
REVIEW
Ricardo Nitrini
Chronic traumatic encephalopathy (CTE) was initially described in boxers, but in recent years it has been reported in other settings, particularly in contact sports and military personnel. Soccer (football association) had previously been (and still is) considered relatively safe when compared to other sports, such as American football. However, a few cases of professional soccer players with CTE have been reported in the last few years. It is still unknown how frequent this condition is in soccer players, and the role played by heading the ball remains elusive...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29207411/magnetic-resonance-spectroscopy-as-a-biomarker-for-chronic-traumatic-encephalopathy
#10
Michael L Alosco, Johnny Jarnagin, Benjamin Rowland, Huijun Liao, Robert A Stern, Alexander Lin
No abstract text is available yet for this article.
October 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/29203673/evidence-for-sortilin-modulating-regional-accumulation-of-human-tau-prions-in-transgenic-mice
#11
Noah R Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A Carlson, Kurt Giles, Stanley B Prusiner
Misfolding of tau proteins into prions and their propagation along neural circuits are thought to result in neurodegeneration causing Alzheimer's disease, progressive supranuclear palsy, chronic traumatic encephalopathy, and other tauopathies. Little is known about the molecular processes mediating tau prion replication and spreading in different brain regions. Using transgenic (Tg) mice with a neuronal promoter driving expression of human mutant (P301S) tau, we found that tau prion formation and histopathologic deposition is largely restricted to the hindbrain...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29186501/the-amygdala-as-a-locus-of-pathologic-misfolding-in-neurodegenerative-diseases
#12
Peter T Nelson, Erin L Abner, Ela Patel, Sonya Anderson, Donna M Wilcock, Richard J Kryscio, Linda J Van Eldik, Gregory A Jicha, Zsombor Gal, Ruth S Nelson, Bela G Nelson, Jozsef Gal, Md Tofial Azam, David W Fardo, Matthew D Cykowski
Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged brains often is accompanied by the misfolding of other proteins, suggesting synergistic mechanisms. The multiplicity of pathogenic processes in human amygdalae has potentially important implications for the pathogenesis of Alzheimer disease, Lewy body diseases, chronic traumatic encephalopathy, primary age-related tauopathy, and hippocampal sclerosis, and for the biomarkers used to diagnose those diseases...
January 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29185187/extracellular-vesicle-biology-in-alzheimer-s-disease-and-related-tauopathy
#13
REVIEW
Annina M DeLeo, Tsuneya Ikezu
Extracellular vesicles (EVs) are physiological vesicles secreted from most eukaryotes and contain cargos of their cell of origin. EVs, and particularly a subset of EV known as exosomes, are emerging as key mediators of cell to cell communication and waste management for cells both during normal organismal function and in disease. In this review, we investigate the rapidly growing field of exosome biology, their biogenesis, cargo loading, and uptake by other cells. We particularly consider the role of exosomes in Alzheimer's disease, both as a pathogenic agent and as a disease biomarker...
November 28, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29181513/sensitivity-to-the-deficits-associated-with-traumatic-brain-injury-or-chronic-traumatic-encephalopathy-reply
#14
Amanda R Rabinowitz, Sameer K Deshpande, Dylan S Small
No abstract text is available yet for this article.
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29181506/sensitivity-to-the-deficits-associated-with-traumatic-brain-injury-or-chronic-traumatic-encephalopathy
#15
Michael Hoffmann
No abstract text is available yet for this article.
November 27, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29157858/imaging-of-cerebral-concussion-and-chronic-traumatic-encephalopathy
#16
EDITORIAL
Eliana Bonfante, Roy Riascos
No abstract text is available yet for this article.
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29157849/imaging-of-chronic-concussion
#17
REVIEW
Eliana Bonfante, Roy Riascos, Octavio Arevalo
Conventional imaging findings in patients with cerebral concussion and chronic traumatic encephalopathy are absent or subtle in the majority of cases. The most common abnormalities include cerebral volume loss, enlargement of the cavum of the septum pellucidum, cerebral microhemorrhages, and white matter signal abnormalities, all of which have poor sensitivity and specificity. Advanced imaging modalities, such as diffusion tensor imaging (DTI), blood oxygen level dependent functional MR Imaging (BOLD fMRI), MR spectroscopy, perfusion imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetoencephalography detect physiologic abnormalities in symptomatic patients and, although currently in the investigation phase, may become useful in the clinical arena...
February 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29155947/dementia-after-moderate-severe-traumatic-brain-injury-coexistence-of-multiple-proteinopathies
#18
Kimbra Kenney, Diego Iacono, Brian L Edlow, Douglas I Katz, Ramon Diaz-Arrastia, Kristen Dams-O'Connor, Daniel H Daneshvar, Allison Stevens, Allison L Moreau, Lee S Tirrell, Ani Varjabedian, Anastasia Yendiki, Andre van der Kouwe, Azma Mareyam, Jennifer A McNab, Wayne A Gordon, Bruce Fischl, Ann C McKee, Daniel P Perl
We report the clinical, neuroimaging, and neuropathologic characteristics of 2 patients who developed early onset dementia after a moderate-severe traumatic brain injury (TBI). Neuropathological evaluation revealed abundant β-amyloid neuritic and cored plaques, diffuse β-amyloid plaques, and frequent hyperphosphorylated-tau neurofibrillary tangles (NFT) involving much of the cortex, including insula and mammillary bodies in both cases. Case 1 additionally showed NFTs in both the superficial and deep cortical layers, occasional perivascular and depth-of-sulci NFTs, and parietal white matter rarefaction, which corresponded with decreased parietal fiber tracts observed on ex vivo MRI...
November 16, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29145658/characterization-of-detergent-insoluble-proteome-in-chronic-traumatic-encephalopathy
#19
Jonathan D Cherry, Ahmad Zeineddin, Eric B Dammer, James A Webster, Duc Duong, Nicholas T Seyfried, Allan I Levey, Victor E Alvarez, Bertrand R Huber, Thor D Stein, Patrick T Kiernan, Ann C McKee, James J Lah, Chadwick M Hales
Quantitative proteomics of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer disease (AD) and frontotemporal dementia. Similar studies in chronic traumatic encephalopathy (CTE) are limited, therefore we hypothesized that proteomic sequencing of CTE frontal cortex brain homogenates from varying CTE pathologic stages may provide important new insights into this disorder. Quantitative proteomics of control, CTE and AD brains was performed to characterize differentially expressed proteins, and we identified over 4000 proteins in CTE brains, including significant enrichment of the microtubule associated protein tau...
November 14, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29136240/postmortem-autopsy-confirmation-of-antemortem-f-18-fddnp-pet-scans-in-a-football-player-with-chronic-traumatic-encephalopathy
#20
Bennet Omalu, Gary W Small, Julian Bailes, Linda M Ercoli, David A Merrill, Koon-Pong Wong, Sung-Cheng Huang, Nagichettiar Satyamurthy, Jennifer L Hammers, John Lee, Robert P Fitzsimmons, Jorge R Barrio
Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest...
November 10, 2017: Neurosurgery
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