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cognition in multiple sclerosis

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https://www.readbyqxmd.com/read/29350300/the-relationship-between-gait-variability-and-cognitive-functions-differs-between-fallers-and-non-fallers-in-ms
#1
Alon Kalron, Roy Aloni, Mark Dolev, Lior Frid, Uri Givon, Shay Menascu
The objective of the study was to determine if cognitive function is associated with step time variability in people with multiple sclerosis (PwMS). The study included 355 PwMS (218 women), average age 41.1 (SD = 13.5), disease duration 5.9 (SD = 7.3) years, and a median expanded disability status scale score of 2.5. We separately analyzed the sample group of fallers and non-fallers based on their fall history. Gait variability was measured by an electronic walkway and all participants completed a computerized cognitive test battery designed to evaluate multiple cognitive domains...
January 19, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29348927/improved-cognitive-performance-and-event-related-potential-changes-following-working-memory-training-in-patients-with-multiple-sclerosis
#2
Thomas J Covey, Janet L Shucard, Ralph Hb Benedict, Bianca Weinstock-Guttman, David W Shucard
Background: Few studies of cognitive rehabilitation in multiple sclerosis (MS) have targeted working memory specifically. Objective: We examined the effects of n-back working memory training on cognitive performance and brain function in patients with MS. Methods: Patients with MS (n = 12) and healthy controls (HC; n = 12) underwent 20 sessions of n-back working memory training. Before and after training (pre- and posttest) cognitive event-related potential (ERP) measures were obtained during a 3-back task...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29346658/potential-for-diet-to-prevent-and-remediate-cognitive-deficits-in-neurological-disorders
#3
Heather M Francis, Richard J Stevenson
The pathophysiology of many neurological disorders involves oxidative stress, neuroinflammation, and mitochondrial dysfunction. There is now substantial evidence that diet can decrease these forms of pathophysiology, and an emerging body of literature relatedly suggests that diet can also prevent or even remediate the cognitive deficits observed in neurological disorders that exhibit such pathology (eg, Alzheimer's disease, multiple sclerosis, age-related cognitive decline, epilepsy). The current review summarizes the emerging evidence in relation to whole diets prominent in the scientific literature-ketogenic, caloric restriction, high polyphenol, and Mediterranean diets-and provides a discussion of the possible underlying neurophysiological mechanisms...
January 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29343470/cognition-in-multiple-sclerosis-state-of-the-field-and-priorities-for-the-future
#4
REVIEW
James F Sumowski, Ralph Benedict, Christian Enzinger, Massimo Filippi, Jeroen J Geurts, Paivi Hamalainen, Hanneke Hulst, Matilde Inglese, Victoria M Leavitt, Maria A Rocca, Eija M Rosti-Otajarvi, Stephen Rao
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thoroughly understand neural bases of cognitive deficits, and (3) develop effective, evidence-based, clinically feasible interventions to prevent or treat cognitive dysfunction, which are lacking. There are obstacles to these goals...
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29341465/p2y12-deficiency-in-mouse-impairs-noradrenergic-system-in-brain-and-alters-anxiety-like-neurobehavior-and-memory
#5
Fang Zheng, Qiang Zhou, Yin Cao, Hailian Shi, Hui Wu, Beibei Zhang, Fei Huang, Xiaojun Wu
Purinergic receptor P2Y12 (P2Y12 ), a G protein-coupled (GPCR) purinergic receptor, is widely distributed in nervous system and involved in the progression of neurological diseases such as multiple sclerosis and neuropathic pain. The central noradrenergic system actively participates in a number of neurophysiological processes. Nevertheless, whether there is any direct relevance between P2Y12 and noradrenergic signal transduction remains unknown. In the present study, we tested the hypothesis that lack of P2Y12 impaired noradrenergic signal transduction in mouse brain...
January 17, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29341025/multiple-sclerosis-prevalence-and-impact
#6
Heather Gilmour, Pamela L Ramage-Morin, Suzy L Wong
This article provides new information about multiple sclerosis (MS) using the 2010/2011 Neurological Conditions Prevalence File, the 2011/2012 Survey of Neurological Conditions in Institutions in Canada, and the 2011 Survey on Living with Neurological Conditions in Canada. An estimated 93,500 Canadians living in private households and 3,800 residents of long-term care institutions had been diagnosed with MS. Prevalence estimates were 159 and 418 cases per 100,000 population for men and women, respectively; 2...
January 17, 2018: Health Reports
https://www.readbyqxmd.com/read/29339837/validation-of-the-brief-international-cognitive-assessment-for-multiple-sclerosis-in-japan
#7
Masaaki Niino, Toshiyuki Fukazawa, Jun-Ichi Kira, Tatsusada Okuno, Masahiro Mori, Nobuo Sanjo, Takashi Ohashi, Hikoaki Fukaura, Juichi Fujimori, Yuko Shimizu, Nobuhiro Mifune, Yusei Miyazaki, Eri Takahashi, Seiji Kikuchi, Dawn Langdon, Ralph Hb Benedict, Makoto Matsui
Background: The Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS). Objectives: We aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls. Methods: The Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs)...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29338134/retinal-oximetry-is-affected-in-multiple-sclerosis
#8
Anna Bryndis Einarsdottir, Olof Birna Olafsdottir, Haukur Hjaltason, Sveinn Hakon Hardarson
PURPOSE: Structural and physiological abnormalities have been reported in the retina in patients with multiple sclerosis (MS). Retinal oximetry has recently detected changes in retinal oxygen metabolism in Alzheimer's disease and mild cognitive impairment. Our goal was to determine whether oxygen saturation in retinal blood vessels of patients with patients is different from that of a healthy population. METHODS: Oxygen saturation of haemoglobin was measured in retinal blood vessels, using imaging with spectrophotometric noninvasive retinal oximeter...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29337024/moderators-of-treatment-outcomes-following-telehealth-self-management-and-education-in-adults-with-multiple-sclerosis-a-secondary-analysis-of-a-randomized-controlled-trial
#9
Dawn M Ehde, Anne Arewasikporn, Kevin N Alschuler, Abbey J Hughes, Aaron P Turner
OBJECTIVE: To examine moderators of treatment effects in a randomized controlled trial comparing a telehealth self-management intervention to a telehealth MS education intervention for fatigue, pain, and mood in adults with multiple sclerosis (MS). DESIGN: Secondary analysis of a single-blind randomized controlled trial. SETTING: community. PARTICIPANTS: Adults with MS and chronic fatigue, chronic pain, and/or moderate depressive symptoms (N=163) recruited from across the United States...
January 11, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29329152/remotely-supervised-transcranial-direct-current-stimulation-after-ect-improves-mood-and-cognition-in-a-patient-with-multiple-sclerosis-a-case-study
#10
Ashley M Clayton, Jonathan Howard, Bryan Dobbs, Michael T Shaw, Leigh E Charvet
No abstract text is available yet for this article.
January 12, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29320933/gray-matter-networks-and-cognitive-impairment-in-multiple-sclerosis
#11
Carolina M Rimkus, Menno M Schoonheim, Martijn D Steenwijk, Hugo Vrenken, Anand Jc Eijlers, Joep Killestein, Mike P Wattjes, Claudia C Leite, Frederik Barkhof, Betty M Tijms
BACKGROUND: Coordinated patterns of gray matter morphology can be represented as networks, and network disruptions may explain cognitive dysfunction related to multiple sclerosis (MS). OBJECTIVE: To investigate whether single-subject gray matter network properties are related to impaired cognition in MS. METHODS: We studied 148 MS patients (99 female) and 33 healthy controls (HC, 21 female). Seven network parameters were computed and compared within MS between cognitively normal and impaired subjects, and associated with performance on neuropsychological tests in six cognitive domains with regression models...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29318028/interferon-beta-1b-in-treatment-na%C3%A3-ve-paediatric-patients-with-relapsing-remitting-multiple-sclerosis-two-year-results-from-the-betapaedic-study
#12
Jutta Gärtner, Wolfgang Brück, Almuth Weddige, Hannah Hummel, Christiane Norenberg, Jörg-Peter Bugge
Background and objective: Study evaluating Betaferon(R)'s safety and tolerability in paediatric patients with multiple sclerosis (BETAPAEDIC) is a prospective, open-label observational multicentre study to assess the safety and effectiveness of interferon beta-1b in paediatric patients with relapsing-remitting multiple sclerosis. Methods: Treatment-naïve patients (12-16 years) scheduled to start interferon beta-1b were enrolled with follow-up visits every six months for two years...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29306741/on-the-role-of-the-amygdala-for-experiencing-fatigue-in-patients-with-multiple-sclerosis
#13
Katrin Hanken, Yoselin Francis, Andreas Kastrup, Paul Eling, Jan Klein, Helmut Hildebrandt
BACKGROUND: Recently, we proposed a model explaining the origin of fatigue in multiple sclerosis (MS) patients. This model assumes that the feeling of fatigue results from inflammation-induced information processing within interoceptive brain areas. OBJECTIVES: To investigate the association between self-reported cognitive fatigue and structural integrity of interoceptive brain areas in MS patients. METHODS: 95 MS patients and 28 healthy controls participated in this study...
December 21, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29306740/efficacy-of-computer-based-cognitive-training-in-neuropsychological-performance-of-patients-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#14
REVIEW
Efthimios Dardiotis, Anastasia Nousia, Vasileios Siokas, Zisis Tsouris, Athina Andravizou, Alexios-Fotios A Mentis, Despoina Florou, Lambros Messinis, Grigorios Nasios
IMPORTANCE: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by relapses and a progressive course that may lead to accumulation of physical and cognitive disability. Cognitive training interventions seem to improve the cognitive performance of MS patients. The aim of the present meta-analysis is to quantitatively investigate the effect of computer-based cognitive rehabilitation on the neuropsychological performance of patients with MS...
December 24, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29305855/microglia-derived-extracellular-vesicles-in-alzheimer-s-disease-a-double-edged-sword
#15
REVIEW
Teresa Trotta, Maria Antonietta Panaro, Antonia Cianciulli, Giorgio Mori, Adriana Di Benedetto, Chiara Porro
Extracellular vesicles (EVs), based on their origin or size, can be classified as apoptotic bodies, microvesicles (MVs)/microparticles (MPs), and exosomes. EVs are one of the new emerging modes of communication between cells that are providing new insights into the pathophysiology of several diseases. EVs released from activated or apoptotic cells contain specific proteins (signaling molecules, receptors, integrins, cytokines), bioactive lipids, nucleic acids (mRNA, miRNA, small non coding RNAs, DNA) from their progenitor cells...
January 3, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29303036/cognitive-reserve-cognition-and-regional-brain-damage-in-ms-a-2%C3%A2-year-longitudinal-study
#16
Maria Assunta Rocca, Gianna C Riccitelli, Alessandro Meani, Elisabetta Pagani, Paola Del Sette, Vittorio Martinelli, Giancarlo Comi, Andrea Falini, Massimo Filippi
BACKGROUND: According to the cognitive reserve (CR) theory, enriching experiences protect against cognitive decline. OBJECTIVES: To investigate the dynamic interaction between CR and global/regional measures of brain white matter (WM) and gray matter (GM) damage and their effect on cognitive performance in multiple sclerosis (MS). METHODS: Baseline and 2 -year three-dimensional (3D) T1-weighted scans were obtained from 54 MS patients and 20 healthy controls...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29301779/what-have-we-learned-from-mr-imaging-in-multiple-sclerosis
#17
REVIEW
E Lapointe, D K B Li, A L Traboulsee, A Rauscher
Using MR imaging, perfusion can be assessed either by dynamic susceptibility contrast MR imaging or arterial spin-labeling. Alterations of cerebral perfusion have repeatedly been described in multiple sclerosis compared with healthy controls. Acute lesions exhibit relative hyperperfusion in comparison with normal-appearing white matter, a finding mostly attributed to inflammation in this stage of lesion development. In contrast, normal-appearing white and gray matter of patients with MS has been mostly found to be hypoperfused compared with controls, and correlations with cognitive impairment as well as fatigue in multiple sclerosis have been described...
January 4, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29300812/naturalistic-assessment-using-a-simulated-environment-cognitive-correlates-and-relationship-to-functional-status-in-individuals-with-neurologic-conditions
#18
Kayela Robertson, Maureen Schmitter-Edgecombe, Douglas Weeks, Jane Pimentel
Objective: Research has shown that neurologic conditions, such as traumatic brain injury and multiple sclerosis, result in a number of cognitive and functional deficits. However, little is known about the relationship between various cognitive domains and ability to perform everyday activities. The Community Shopping Task (CST), a naturalistic assessment task conducted in a simulated environment, was used to examine functional abilities and cognitive correlates of everyday functioning in individuals with neurologic conditions...
December 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29300228/loneliness-in-multiple-sclerosis-possible-antecedents-and-correlates
#19
Julia M Balto, Lara A Pilutti, Robert W Motl
PURPOSE: The prevalence and possible antecedents and correlates of loneliness in multiple sclerosis (MS) was examined. DESIGN: Cross-sectional, comparative study of MS (n = 63) and healthy adults (n = 21). METHODS: Data were collected using self-reports of loneliness and antecedents and correlates and analyzed using inferential statistics. FINDINGS: Those with MS had significantly higher loneliness scores than healthy adults (p < ...
January 3, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29297273/circulating-levels-of-interleukin-17a-tumor-necrosis-factor-alpha-interleukin-18-interleukin-10-and-cognitive-performance-of-patients-with-relapsing-remitting-multiple-sclerosis
#20
Anastasiya G Trenova, Georgi S Slavov, Milena N Draganova-Filipova, Nonka G Mateva, Mariya G Manova, Lyuba D Miteva, Spaska A Stanilova
Multiple sclerosis (MS) is associated with cytokine imbalance and high rate (40-70%) of cognitive impairment. The objective of this study is to investigate the relationship between serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-17A, IL-18, IL-10, and cognitive performance in patients with relapsing-remitting MS (RRMS). Methods The study comprised 159 patients with RRMS (mean age 40.08 ± 8.48 years) in remission phase and 86 age-, gender-, and education-matched healthy controls...
January 3, 2018: Neurological Research
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