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https://www.readbyqxmd.com/read/28318585/lactoferrin-reduces-mortality-in-preweaned-calves-with-diarrhea
#1
G Habing, K Harris, G M Schuenemann, J M Piñeiro, J Lakritz, X Alcaraz Clavijo
Calf diarrhea is the most common reason for mortality and antimicrobial therapy in preweaned calves on dairy farms in the United States. Conventional and organic livestock producers require alternative therapies for calf diarrhea to reduce the necessity of conventional antimicrobials. Alternatives administered for mild cases or early in the disease course may be useful to mitigate disease progression and reduce the likelihood of septicemia and negative sequelae. Lactoferrin is a bioactive protein naturally found in colostrum that has been shown to prevent septicemia in high-risk infants...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28304355/the-glyoxalase-system-and-methylglyoxal-derived-carbonyl-stress-in-sepsis-glycotoxic-aspects-of-sepsis-pathophysiology
#2
REVIEW
Thomas Schmoch, Florian Uhle, Benedikt H Siegler, Thomas Fleming, Jakob Morgenstern, Peter P Nawroth, Markus A Weigand, Thorsten Brenner
Sepsis remains one of the leading causes of death in intensive care units. Although sepsis is caused by a viral, fungal or bacterial infection, it is the dysregulated generalized host response that ultimately leads to severe dysfunction of multiple organs and death. The concomitant profound metabolic changes are characterized by hyperglycemia, insulin resistance, and profound transformations of the intracellular energy supply in both peripheral and immune cells. A further hallmark of the early phases of sepsis is a massive formation of reactive oxygen (ROS; e...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28302579/the-baff-april-axis-plays-an-important-role-in-virus-induced-peritoneal-responses-in-rainbow-trout
#3
Irene Soleto, Beatriz Abós, Rosario Castro, Lucia González, Carolina Tafalla, Aitor G Granja
IgM(+) B cells have been recently demonstrated to be key regulators of peritoneal inflammation in teleost, as a large number of them occupy the peritoneal cavity after 48 h of antigenic stimulation. Despite this, the number of studies addressing the mechanism through which this cell population expands and differentiates in response to stimuli has been scarcely addressed. Because the BAFF/APRIL axis is known to play a major role in B cell survival and differentiation in mammals, we hypothesized that it could be affected in the peritoneal cavity in response to an inflammatory stimulus...
March 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28298693/occurrence-of-clinical-genotype-vibrio-vulnificus-in-clam-samples-in-mangalore-southwest-coast-of-india
#4
M S Sangeetha, Malathi Shekar, M N Venugopal
Vibrio vulnificus is an opportunistic human pathogen causing gastroenteritis, wound infection and primary septicemia. V. vulnificus population has been divided into subpopulations based on their phenotype and genotype characteristics. In this study, 38.5% (10/26) of clam (Meretrix meretrix) samples obtained from Mangalore markets were seen to harbor V. vulnificus. Biochemical characterization of V. vulnificus isolates showed the strains to belong to Biotype 1 phenotype. Genotyping of strains using the 16S rRNA and virulence correlated gene (vcg) typing methods identified the isolates to be of 16S rRNA typeB and vcgC type respectively...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28297597/leptospirosis-and-depression-a-nationwide-cohort-analysis
#5
Chun-Hsiang Chiu, Ying-Chuan Wang, Cheng-Li Lin, Feng-You Lee, Chia-Hung Kao
OBJECTIVE: We conducted a retrospective cohort study to investigate whether leptospirosis is a risk factor for depression. METHOD: From the Taiwan National Health Insurance Research Database between 2000 and 2010, patients with leptospirosis (ICD-9 code 100) who did not have a history of depression (ICD-9-CM codes 296.2, 296.3, 300.4, and 311) before the index date were enrolled (leptospirosis cohort). For each patient with leptospirosis, 1 control without a history of leptospirosis and depression was randomly selected (nonleptospirosis cohort)...
March 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28294970/krill-oil-in-water-emulsion-protects-against-lipopolysaccharide-induced-proinflammatory-activation-of-macrophages-in-vitro
#6
Gabriel A Bonaterra, David Driscoll, Hans Schwarzbach, Ralf Kinscherf
BACKGROUND: Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phases of critical illness. Concerning anti-inflammatory properties in this setting, omega-3 fatty acids of marine origin have been frequently described. This study investigated the anti-inflammatory and LPS-inactivating properties of krill oil (KO)-in-water emulsion in human macrophages in vitro...
March 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28293008/-successful-emergency-management-of-an-infected-thoracic-aortic-aneurysm-rupture-using-a-pedicled-latissimus-dorsi-flap-after-stent-graft-implantation-report-of-a-case
#7
Susumu Takeuchi, Hiroyuki Tanaka, Yoshiro Hori
We report a case of ruptured mycotic thoracic aortic aneurysm treated with a pedicled latissimus dorsi flap after stent-graft implantation. The patient was a 64-year-old woman with diabetes mellitus that had developed septicemia as a result of pyelonephritis and a perinephric abscess. The patient required emergency stent-graft implantation due to rupture of an infected thoracic aortic aneurysm on hospital day 10. On hospital day 19, the abscess cavity was debrided and irrigated, and a pedicled latissimus dorsi flap was created...
March 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28291943/a-new-combination-of-a-pleuromutilin-derivative-and-doxycycline-for-treatment-of-multidrug-resistant-acinetobacter-baumannii
#8
Shajila Siricilla, Katsuhiko Mitachi, Junshu Yang, Shakiba Eslamimehr, Maddie R Lemieux, Bernd Meibohm, Yinduo Ji, Michio Kurosu
Multidrug-resistant (MDR) Acinetobacter baumannii is one of the most difficult Gram-negative bacteria to treat and eradicate. In a cell-based screening of pleuromutilin derivatives against a drug sensitive A. baumannii strain (ATCC 19606), new molecules (2-4) exhibit bacteriostatic activity with 3.13 μg/mL concentration and 1 shows bactericidal activity with an MBC of 6.25 μg/mL. The pleuromutilin derivative 1 displays strong synergistic effects with doxycycline in a wide range of concentrations. A 35/1 ratio of 1 and doxycycline (1-Dox35/1) kills drug susceptible A...
March 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28288467/tattoo-infections-personal-resistance-and-contagious-exposure-through-tattooing
#9
Jørgen Serup
Bacterial infection of tattoos remains a common complication. Pyogenic bacteria can cause infections shortly after the tattoo is made. Severity of infection varies from minor to major, ultimately with life-threatening septicemia. Viral infections may be introduced, i.e. HVB, HVC, and HIV. The risk of infection depends on the following triad: microbial pathogen and its aggressiveness, individual resistance of the tattooed, and inoculation and exposures by the tattoo needle and in the tattoo parlor. Some infectious risks can be controlled...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28287269/a-critical-review-of-analytical-methods-for-quantification-of-cefotaxime
#10
Lívia Paganini Consortti, Hérida Regina Nunes Salgado
Bacterial resistance to antibiotics is a growing phenomenon in the world. Considering the relevance of antimicrobials for population and the reduction in the registration of new antimicrobials by regulatory, proper quality control is required in order to minimize the spread of bacterial resistance and ensure the effectiveness of a treatment, as well as safety for the patient. Among the antimicrobials is cefotaxime, a drug belonging to third-generation cephalosporins, which is highly active against Gram-negative bactéria and is used to treat central nervous system infections such as meningitis and septicemia...
March 13, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28286775/demographics-and-clinical-features-of-postresuscitation-comorbidities-in-long-term-survivors-of-out-of-hospital-cardiac-arrest-a-national-follow-up-study
#11
Chih-Pei Su, Jr-Hau Wu, Mei-Chueh Yang, Ching-Hui Liao, Hsiu-Ying Hsu, Chin-Fu Chang, Shou-Jen Lan, Chiao-Lee Chu, Yan-Ren Lin
The outcome of patients suffering from out-of-hospital cardiac arrest (OHCA) is very poor, and postresuscitation comorbidities increase long-term mortality. This study aims to analyze new-onset postresuscitation comorbidities in patients who survived from OHCA for over one year. The Taiwan National Health Insurance (NHI) Database was used in this study. Study and comparison groups were created to analyze the risk of suffering from new-onset postresuscitation comorbidities from 2011 to 2012 (until December 31, 2013)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28286149/interaction-of-francisella-noatunensis-subsp-orientalis-with-oreochromis-mossambicus-bulbus-arteriosus-cell-line
#12
Esteban Soto, Susan Yun, Jainee Lewis, Michael T Kearney, John Hansen
Francisella noatunensis subsp. orientalis (Fno) (syn. F. asiatica) is an emergent warmwater fish pathogen and the causative agent of piscine francisellosis. Although Fno causes septicemia and can live extracellularly in infected tilapia (Oreochromis spp.), the early interaction of Fno with vasculature endothelium is unknown. In the present study, we examined the interaction of wild-type Fno (WT) and two Fno knockout [intracellular growth loci C (ΔiglC) and pathogenicity determinant protein A (ΔpdpA)] strains with the endothelial O...
March 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28285784/pediatric-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-the-united-states
#13
Derek Y Hsu, Joaquin Brieva, Nanette B Silverberg, Amy S Paller, Jonathan I Silverberg
BACKGROUND: Little is known about the epidemiology of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children. OBJECTIVE: We sought to determine the morbidity, mortality, and comorbid health conditions of SJS and TEN in US children. METHODS: This was a cross-sectional study of the 2009 to 2012 Nationwide Inpatient Sample, which contains a representative 20% sample of all US hospitalizations. Sociodemographics, inflation-adjusted cost, length of stay, comorbidities, and mortality were analyzed using descriptive statistics and multivariate regression analyses...
March 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28284621/identification-of-a-novel-host-specific-igg-protease-in-streptococcus-phocae-subsp-phocae
#14
Viktoria Rungelrath, Jan Christian Wohlsein, Ursula Siebert, Jeffrey Stott, Ellen Prenger-Berninghoff, Ulrich von Pawel-Rammingen, Peter Valentin-Weigand, Christoph G Baums, Jana Seele
Streptococcus (S.) phocae subsp. phocae causes bronchopneumonia and septicemia in a variety of marine mammals. Especially in harbor seals infected with phocine distemper virus it plays an important role as an opportunistic pathogen. This study was initiated by the detection of IgG cleavage products in Western blot analysis after incubation of bacterial supernatant with harbor seal serum. Hence, the objectives of this study were the identification and characterization of a secreted IgG cleaving protease in S...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28283139/incidences-of-waterborne-and-foodborne-diseases-after-meteorologic-disasters-in-south-korea
#15
Wonwoong Na, Kyeong Eun Lee, Hyung-Nam Myung, Soo-Nam Jo, Jae-Yeon Jang
BACKGROUND: Climate change could increase the number of regions affected by meteorologic disasters. Meteorologic disasters can increase the risk of infectious disease outbreaks, including waterborne and foodborne diseases. Although many outbreaks of waterborne diseases after single disasters have been analyzed, there have not been sufficient studies reporting comprehensive analyses of cases occurring during long-term surveillance after multiple disasters, which could provide evidence of whether meteorologic disasters cause infectious disease outbreaks...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28276468/nv-proteins-of-fish-novirhabdovirus-recruit-cellular-ppm1bb-protein-phosphatase-and-antagonize-rig-i-mediated-ifn-induction
#16
Stéphane Biacchesi, Emilie Mérour, Didier Chevret, Annie Lamoureux, Julie Bernard, Michel Brémont
Non virion (NV) protein expression is critical for fish Novirhabdovirus, viral hemorrhagic septicemia virus (VHSV) and infectious hematopoietic necrosis virus (IHNV), in vivo pathogenesis. However, the mechanism by which NV promotes the viral replication is still unclear. We developed an approach based on reverse genetics and interactomic and identified several NV-associated cellular partners underlying cellular pathways as potential viral targets. Among these cell partners, we showed that NV proteins specifically interact with a protein phosphatase, Mg(2+)/Mn(2+)-dependent, 1Bb (PPM1Bb) and recruit it in the close vicinity of mitochondria, a subcellular compartment important for retinoic acid-inducible gene-I- (RIG-I)-mediated interferon induction pathway...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274521/cavopulmonary-anastomosis-during-same-hospitalization-as-stage-1-norwood-hybrid-palliative-surgery
#17
Sachin D Tadphale, Xinyu Tang, Nahed O ElHassan, Brandon Beam, Parthak Prodhan
BACKGROUND: Limited literature has examined characteristics of infants with hypoplastic left heart syndrome (HLHS) who remain hospitalized during the interstage period. We described their epidemiologic characteristics, in-hospital outcomes, and identified risk factors that predict the need for superior cavopulmonary anastomosis (SCPA) during the same hospitalization. METHODS: This retrospective multicenter database analysis included infants with HLHS who underwent stage 1 palliation from 2004 through 2013...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28273858/use-of-a-pan-genomic-dna-microarray-in-determination-of-the-phylogenetic-relatedness-among-cronobacter-spp-and-its-use-as-a-data-mining-tool-to-understand-cronobacter-biology
#18
REVIEW
Ben D Tall, Jayanthi Gangiredla, Christopher J Grim, Isha R Patel, Scott A Jackson, Mark K Mammel, Mahendra H Kothary, Venugopal Sathyamoorthy, Laurenda Carter, Séamus Fanning, Carol Iversen, Franco Pagotto, Roger Stephan, Angelika Lehner, Jeffery Farber, Qiong Q Yan, Gopal R Gopinath
Cronobacter (previously known as Enterobacter sakazakii) is a genus of Gram-negative, facultatively anaerobic, oxidase-negative, catalase-positive, rod-shaped bacteria of the family Enterobacteriaceae. These organisms cause a variety of illnesses such as meningitis, necrotizing enterocolitis, and septicemia in neonates and infants, and urinary tract, wound, abscesses or surgical site infections, septicemia, and pneumonia in adults. The total gene content of 379 strains of Cronobacter spp. and taxonomically-related isolates was determined using a recently reported DNA microarray...
March 4, 2017: Microarrays
https://www.readbyqxmd.com/read/28272077/changing-trend-in-bacterial-etiology-and-antibiotic-resistance-in-sepsis-of-intramural-neonates-at-a-tertiary-care-hospital
#19
M P Roy, M Bhatt, V Maurya, S Arya, R Gaind, H K Chellani
BACKGROUND: Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates. MATERIALS AND METHODS: A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999-2014, divided into five phases...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28268063/human-escherichia-coli-isolates-from-hemocultures-septicemia-linked-to-urogenital-tract-infections-is-caused-by-isolates-harboring-more-virulence-genes-than-bacteraemia-linked-to-other-conditions
#20
Lenka Micenková, Alžbeta Beňová, Lucia Frankovičová, Juraj Bosák, Martin Vrba, Alena Ševčíková, Marta Kmeťová, David Šmajs
Escherichia coli is the most common cause of bloodstream infections and community-acquired sepsis. The main aim of this study was to determine virulence characteristics of E. coli isolates from hemocultures of patients with a primary disease of urogenital tract, digestive system, a neoplastic blood disease, or other conditions. Results from a set of 314 E. coli isolates from hemocultures were compared to data from a previously published analysis of 1283 fecal commensal E. coli isolates. Genetic profiling of the 314 E...
February 27, 2017: International Journal of Medical Microbiology: IJMM
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