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Fucoxanthin

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https://www.readbyqxmd.com/read/29291370/fucoxanthin-and-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-synergistically-promotes-apoptosis-of-human-cervical-cancer-cells-by-targeting-pi3k-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Ye Jin, Shuang Qiu, Na Shao, Jianhua Zheng
BACKGROUND Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that selectively induces apoptosis in many tumor cells and is an attractive candidate for antitumor therapies. MATERIAL AND METHODS After human cervical cancer cell lines HeLa, SiHa, and CaSki were treated with fucoxanthin or TRAIL. Cell viability was determined by 2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2-tetrazolium 5-carboxanilide (XTT) method...
January 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29229806/how-reduced-excitonic-coupling-enhances-light-harvesting-in-the-main-photosynthetic-antennae-of-diatoms
#2
Tjaart P J Krüger, Pavel Malý, Maxime T A Alexandre, Tomáš Mančal, Claudia Büchel, Rienk van Grondelle
Strong excitonic interactions are a key design strategy in photosynthetic light harvesting, expanding the spectral cross-section for light absorption and creating considerably faster and more robust excitation energy transfer. These molecular excitons are a direct result of exceptionally densely packed pigments in photosynthetic proteins. The main light-harvesting complexes of diatoms, known as fucoxanthin-chlorophyll proteins (FCPs), are an exception, displaying surprisingly weak excitonic coupling between their chlorophyll (Chl) a's, despite a high pigment density...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29222657/protective-effects-of-fucoxanthin-and-fucoxanthinol-against-tributyltin-induced-oxidative-stress-in-hepg2-cells
#3
Jie Zeng, Yiping Zhang, Jinpeng Ruan, Zhenggang Yang, Chonggang Wang, Zhuan Hong, Zhenghong Zuo
Tributyltin (TBT) is a biocide extremely toxic to a wide range of organisms, which has been used for decades for industrial purposes. Fucoxanthin is a natural carotenoid that is isolated from seaweed, and fucoxanthinol is a major primary metabolite of fucoxanthin. Although fucoxanthin and fucoxanthinol have been reported to possess anti-oxidant activities in vitro, little is known as to whether they protect against TBT-induced oxidative stress in cultured cells. In the present study, the protective effect of fucoxanthin and fucoxanthinol against oxidative stress induced by TBT was investigated...
December 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29172481/fucoxanthin-and-its-metabolite-fucoxanthinol-do-not-induce-browning-in-human-adipocytes
#4
Candida J Rebello, Frank L Greenway, William Johnson, David Ribnicky, Alexander Poulev, Krisztian Stadler, Ann Coulter
Evidence from rodent studies suggests that the anti-obesity effects of fucoxanthin relate to the activation of brown fat and the conversion of white adipocytes to the brown phenotype as well as to downregulation of adipocyte differentiation. Further, obese females given a fucoxanthin supplement for 12 weeks displayed a reduction in body weight. In this study, fucoxanthinol the metabolite present in human plasma, stimulated lipolysis acutely in human adipocytes. However, there was no effect on oxygen consumption rate or the mRNA expression of UCP1, CPT-1β, and GLUT4, the genes largely associated with the browning of adipose tissue and consequential metabolic effects, when human adipocytes were treated with fucoxanthin or fucoxanthinol...
November 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29168774/carotenoids-from-marine-organisms-biological-functions-and-industrial-applications
#5
REVIEW
Christian Galasso, Cinzia Corinaldesi, Clementina Sansone
As is the case for terrestrial organisms, carotenoids represent the most common group of pigments in marine environments. They are generally biosynthesized by all autotrophic marine organisms, such as bacteria and archaea, algae and fungi. Some heterotrophic organisms also contain carotenoids probably accumulated from food or partly modified through metabolic reactions. These natural pigments are divided into two chemical classes: carotenes (such as lycopene and α- and β-carotene) that are composed of hydrogen and carbon; xanthophylls (such as astaxanthin, fucoxanthin and lutein), which are constituted by hydrogen, carbon and oxygen...
November 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29164416/high-throughput-and-direct-measurement-of-androgen-levels-using-turbulent-flow-chromatography-liquid-chromatography-triple-quadrupole-mass-spectrometry-tfc-lc-tqms-to-discover-chemicals-that-modulate-dihydrotestosterone-production-in-human-prostate-cancer-cells
#6
Kyungsu Kang, Lei Peng, Yu-Jin Jung, Joo Yeon Kim, Eun Ha Lee, Hee Ju Lee, Sang Min Kim, Sang Hyun Sung, Cheol-Ho Pan, Yongsoo Choi
OBJECTIVES: To develop a high-throughput screening system to measure the conversion of testosterone to dihydrotestosterone (DHT) in cultured human prostate cancer cells using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS). RESULTS: After optimizing the cell reaction system, this method demonstrated a screening capability of 103 samples, including 78 single compounds and 25 extracts, in less than 12 h without manual sample preparation...
November 21, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29157606/high-performance-thin-layer-chromatography-hptlc-direct-bioautography-as-a-method-of-choice-for-alpha-amylase-and-antioxidant-activity-evaluation-in-marine-algae
#7
Snezana Agatonovic-Kustrin, David W Morton
High-Performance Thin-layer chromatography (HPTLC) combined with DPPH free radical method and α-amylase bioassay was used to compare antioxidant and antidiabetic activities in ethanol and ethyl acetate extracts from 10 marine macroalgae species (3 Chlorophyta, 4 Phaeophyta and 3 Rhodophyta) from Blue Lagoon beach (Malaysia). Samples were also evaluated for their phenolic and stigmasterol content. On average, higher antioxidant activity was observed in the ethyl acetate extracts (55.1mg/100g gallic acid equivalents (GAE) compared to 35...
November 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29113798/fucoxanthin-attenuates-fatty-acid-induced-lipid-accumulation-in-fl83b-hepatocytes-through-regulated-sirt1-ampk-signaling-pathway
#8
Yi-Hsien Chang, Ya-Ling Chen, Wen-Chung Huang, Chian-Jiun Liou
The fucoxanthin, isolated from brown algae, was reported to have multiple biological functions to anti-inflammation, anti-tumor, and ameliorated obesity in mice. In this study we investigated whether fucoxanthin could inhibit lipids accumulation in FL83B hepatocytes. FL83B cells were induced as fatty liver cell model by 0.5 mM oleic acid for 48 h, and treated with various concentration of fucoxanthin for 24 h. The results demonstrated that fucoxanthin significantly suppressed lipid accumulation and decreased lipid peroxidation in hepatocytes...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29110251/inhibition-of-two-gastric-cancer-cell-lines-induced-by-fucoxanthin-involves-downregulation-of-mcl-1-and-stat3
#9
Rui-Xue Yu, Rui-Tao Yu, Zhong Liu
Fucoxanthin is a natural carotenoid that had never been previously demonstrated to have anti-tumor effect on human gastric adenocarcinoma SGC-7901 or BGC-823 cells. Here it was found to inhibit proliferation and induce apoptosis through JAK/STAT signal pathway in these cells; the mechanism by which this occurred was investigated. We find that fucoxanthin significantly increased the number of apoptotic cells by propidium iodide (PI) dye staining and flow cytometry. Fucoxanthin (50 or 75 μM) induced SGC-7901 cells cycle arrest at S phase, while BGC-823 cells arrest at G2/M phase...
November 6, 2017: Human Cell
https://www.readbyqxmd.com/read/29071425/variation-with-depth-of-the-abundance-diversity-and-pigmentation-of-culturable-bacteria-in-a-deep-ice-core-from-the-yuzhufeng-glacier-tibetan-plateau
#10
Liang Shen, Yongqin Liu, Ninglian Wang, Nianzhi Jiao, Baiqing Xu, Xiaobo Liu
It has been suggested that the cryosphere is a new biome uniquely dominated by microorganisms, although the ecological characteristics of these cold-adapted bacteria are not well understood. We investigated the vertical variation with depth of the proportion of pigmented bacteria recovered from an ice core drilled in the Yuzhufeng Glacier, Tibetan Plateau. A total of 25,449 colonies were obtained from 1250 ice core sections. Colonies grew on only one-third of the inoculated Petri dishes, indicating that although the ice core harbored abundant culturable bacteria, bacteria could not be isolated from every section...
October 25, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29059446/action-spectrum-of-photoinhibition-in-the-diatom-phaeodactylum-tricornutum
#11
Vesa Havurinne, Esa Tyystjärvi
Light dependent electron transfer is necessary for photosynthesis but light also damages PSII. Light induced damage to PSII is called photoinhibition and the damaging reactions of photoinhibition are still under debate. Diatoms possess an exotic combination of light harvesting pigments, chlorophylls a/c and fucoxanthin, making them an interesting platform for studying the photoreceptors of photoinhibition. We first confirmed the direct proportionality of photoinhibition to the photon flux density of incident light in the diatom Phaeodactylum tricornutum...
October 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29030666/lc-pda-apciitms-identification-of-algal-carotenoid-and-oxysterol-precursors-to-fatty-acid-esters-in-hydrolyzed-extracts-of-the-freshwater-mussel-dreissena-bugensis
#12
Maxime C Bridoux, Monika Sobiechowska, Alicia Pérez-Fuentetaja, Katherine T Alben
Carotenyl fatty acid esters (carotenyl-FAEs) were extracted in acetone from freeze-dried Dreissena bugensis (Lakes Erie and Ontario) and hydrolyzed to identify the carotenoid precursors. Analysis by liquid chromatography (LC) with photodiode array (PDA) and atmospheric pressure chemical ionization-ion trap mass spectrometry (APCIitMS) revealed the major hydrolysis products: fucoxanthinol (FOH) from fucoxanthin (FX, diatoms); mactraxanthin (MX) from violaxanthin (VX, chlorophytes); 4-fold higher levels of an unknown, tentatively identified as an adduct of two closely eluting C27H46O3 and C27H48O3 steryl triols...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29024505/photoelectrochemical-complexes-of-fucoxanthin-chlorophyll-protein-for-bio-photovoltaic-conversion-with-a-high-open-circuit-photovoltage
#13
Tianning Zhang, Cheng Liu, Wenjing Dong, Wenda Wang, Yan Sun, Xin Chen, Chunhong Yang, Ning Dai
Open-circuit photovoltage (Voc ) is among the critical parameters for achieving an efficient light-to-charge conversion in existing solar photovoltaic devices. Natural photosynthesis exploits light-harvesting chlorophyll (Chl) protein complexes to transfer sunlight energy efficiently. We describe the exploitation of photosynthetic fucoxanthin-chlorophyll protein (FCP) complexes for realizing photoelectrochemical cells with a high Voc . An antenna-dependent photocurrent response and a Voc up to 0.72 V are observed and demonstrated in the bio-photovoltaic devices fabricated with photosynthetic FCP complexes and TiO2 nanostructures...
October 11, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28990814/induction-of-anoikis-in-human-colorectal-cancer-cells-by-fucoxanthinol
#14
Masaru Terasaki, Hayato Maeda, Kazuo Miyashita, Michihiro Mutoh
Fucoxanthin (Fx), one of the major xanthophylls in brown algae, is known to be effective for colorectal cancer (CRC) chemoprevention through inhibiting cell growth, cell cycle and caspase activation. Recently, we observed fucoxanthinol (FuOH), an anti-cancer active metabolite of Fx, treatment of human CRC cells resulted in plenty of living floating cells several hours after exposure, and induced apoptosis. In the present study, we investigated whether FuOH induced anchorage-dependent apoptosis, that is "anoikis", along with integrin signal suppression in human CRC cells...
October 9, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28984834/dual-biological-functions-of-a-cytoprotective-effect-and-apoptosis-induction-by-bioavailable-marine-carotenoid-fucoxanthinol-through-modulation-of-the-nrf2-activation-in-raw264-7-macrophage-cells
#15
Junsei Taira, Miki Sonamoto, Masatsugu Uehara
In this study, the function of fucoxanthinol (FxOH) as a bioavailable marine carotenoid together with the pre-metabolite, fucoxanthin (Fx), was examined through the Nrf2-ARE pathway. The antioxidant activity in the low concentration range of the compounds (1-4 μM) with a peroxyl radical scavenging capacity was proved by the ORAC (Oxygen Radical Absorbance Capacity) method and an ESR study. Similar concentrations of the compound also activated the Nrf2-ARE signaling with the Nrf2 translocation into the nuclear, then the expression of the antioxidant protein HO-1 increased...
October 6, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28928905/fucoxanthin-a-marine-carotenoid-attenuates-%C3%AE-amyloid-oligomer-induced-neurotoxicity-possibly-via-regulating-the-pi3k-akt-and-the-erk-pathways-in-sh-sy5y-cells
#16
Jiajia Lin, Jie Yu, Jiaying Zhao, Ke Zhang, Jiachen Zheng, Jialing Wang, Chunhui Huang, Jingrong Zhang, Xiaojun Yan, William H Gerwick, Qinwen Wang, Wei Cui, Shan He
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of β-amyloid (Aβ) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented Aβ oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28865626/characterization-of-dietary-fucoxanthin-from-himanthalia-elongata-brown-seaweed
#17
Gaurav Rajauria, Barry Foley, Nissreen Abu-Ghannam
This study explored Himanthalia elongata brown seaweed as a potential source of dietary fucoxanthin which is a promising medicinal and nutritional ingredient. The seaweed was extracted with low polarity solvents (n-hexane, diethyl ether, and chloroform) and the crude extract was purified with preparative thin layer chromatography (P-TLC). Identification, quantification and structure elucidation of purified compounds was performed by LC-DAD-ESI-MS and NMR ((1)H and (13)C). P-TLC led purification yielded 18.6mg/g fucoxanthin with 97% of purity based on the calibration curve, in single-step purification...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28865617/development-of-new-green-processes-for-the-recovery-of-bioactives-from-phaeodactylum-tricornutum
#18
Bienvenida Gilbert-López, Almudena Barranco, Miguel Herrero, Alejandro Cifuentes, Elena Ibáñez
Two novel extraction techniques, pressurized liquid extraction (PLE) and microwave-assisted solvent extraction (MAE) have been evaluated for the recovery of bioactive compounds from Phaeodactylum tricornutum. Microalga P. tricornutum is rich in polyunsaturated fatty acids (PUFAs), such as EPA, and has a high content of the carotenoid fucoxanthin, which is a valuable pigment with several biological activities. Cells were disrupted at high pressure and then freeze-dried as a previous step to extraction. Additionally, only green solvents as water and ethanol (EtOH) - and mixtures of them - were used...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28856533/evidence-of-the-supercomplex-organization-of-photosystem-ii-and-light-harvesting-complexes-in-nannochloropsis-granulata
#19
Ikumi Umetani, Motoshi Kunugi, Makio Yokono, Atsushi Takabayashi, Ayumi Tanaka
Diverse light-harvesting complexes (LHCs) have been found in photosynthetic microalgae that originated from secondary endosymbiosis involving primary red algae. However, the associations between LHCs and photosystem I (PSI) and photosystem II (PSII) in these microalgae are not fully understood. Eustigmatophyta is a red algal lineage that appears to have a unique organization in its photosynthetic machinery, consisting of only chlorophyll a and carotenoids that are atypical compared with other closely related groups...
August 30, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28764959/photoprotective-responses-in-a-brown-macroalgae-cystoseira-tamariscifolia-to-increases-in-co2-and-temperature
#20
Paula S M Celis-Plá, Brezo Martínez, Nathalie Korbee, Jason M Hall-Spencer, Félix L Figueroa
Global warming and ocean acidification are increasingly affecting coastal ecosystems, with impacts that vary regionally depending upon local biogeography. Ocean acidification drives shifts in seaweed community dominance that depend on interactions with other factors such as light and nutrients. In this study, we investigated the photophysiological responses in the brown macroalgae species Cystoseira tamariscifolia (Hudson) Papenfuss with important structural role in the coastal Mediterranean communities. These algae were collected in the Cabo de Gata-Nijar Natural Park in ultraoligotrophic waters (algae exposed under high irradiance and less nutrient conditions) vs...
July 20, 2017: Marine Environmental Research
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