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Fucoxanthin

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https://www.readbyqxmd.com/read/28928905/fucoxanthin-a-marine-carotenoid-attenuates-%C3%AE-amyloid-oligomer-induced-neurotoxicity-possibly-via-regulating-the-pi3k-akt-and-the-erk-pathways-in-sh-sy5y-cells
#1
Jiajia Lin, Jie Yu, Jiaying Zhao, Ke Zhang, Jiachen Zheng, Jialing Wang, Chunhui Huang, Jingrong Zhang, Xiaojun Yan, William H Gerwick, Qinwen Wang, Wei Cui, Shan He
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of β-amyloid (Aβ) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented Aβ oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28865626/characterization-of-dietary-fucoxanthin-from-himanthalia-elongata-brown-seaweed
#2
Gaurav Rajauria, Barry Foley, Nissreen Abu-Ghannam
This study explored Himanthalia elongata brown seaweed as a potential source of dietary fucoxanthin which is a promising medicinal and nutritional ingredient. The seaweed was extracted with low polarity solvents (n-hexane, diethyl ether, and chloroform) and the crude extract was purified with preparative thin layer chromatography (P-TLC). Identification, quantification and structure elucidation of purified compounds was performed by LC-DAD-ESI-MS and NMR ((1)H and (13)C). P-TLC led purification yielded 18.6mg/g fucoxanthin with 97% of purity based on the calibration curve, in single-step purification...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28865617/development-of-new-green-processes-for-the-recovery-of-bioactives-from-phaeodactylum-tricornutum
#3
Bienvenida Gilbert-López, Almudena Barranco, Miguel Herrero, Alejandro Cifuentes, Elena Ibáñez
Two novel extraction techniques, pressurized liquid extraction (PLE) and microwave-assisted solvent extraction (MAE) have been evaluated for the recovery of bioactive compounds from Phaeodactylum tricornutum. Microalga P. tricornutum is rich in polyunsaturated fatty acids (PUFAs), such as EPA, and has a high content of the carotenoid fucoxanthin, which is a valuable pigment with several biological activities. Cells were disrupted at high pressure and then freeze-dried as a previous step to extraction. Additionally, only green solvents as water and ethanol (EtOH) - and mixtures of them - were used...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28856533/evidence-of-the-supercomplex-organization-of-photosystem-ii-and-light-harvesting-complexes-in-nannochloropsis-granulata
#4
Ikumi Umetani, Motoshi Kunugi, Makio Yokono, Atsushi Takabayashi, Ayumi Tanaka
Diverse light-harvesting complexes (LHCs) have been found in photosynthetic microalgae that originated from secondary endosymbiosis involving primary red algae. However, the associations between LHCs and photosystem I (PSI) and photosystem II (PSII) in these microalgae are not fully understood. Eustigmatophyta is a red algal lineage that appears to have a unique organization in its photosynthetic machinery, consisting of only chlorophyll a and carotenoids that are atypical compared with other closely related groups...
August 30, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28764959/photoprotective-responses-in-a-brown-macroalgae-cystoseira-tamariscifolia-to-increases-in-co2-and-temperature
#5
Paula S M Celis-Plá, Brezo Martínez, Nathalie Korbee, Jason M Hall-Spencer, Félix L Figueroa
Global warming and ocean acidification are increasingly affecting coastal ecosystems, with impacts that vary regionally depending upon local biogeography. Ocean acidification drives shifts in seaweed community dominance that depend on interactions with other factors such as light and nutrients. In this study, we investigated the photophysiological responses in the brown macroalgae species Cystoseira tamariscifolia (Hudson) Papenfuss with important structural role in the coastal Mediterranean communities. These algae were collected in the Cabo de Gata-Nijar Natural Park in ultraoligotrophic waters (algae exposed under high irradiance and less nutrient conditions) vs...
July 20, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28751806/a-marine-bio-functional-lipid-fucoxanthinol-attenuates-human-colorectal-cancer-stem-like-cell-tumorigenicity-and-sphere-formation
#6
Masaru Terasaki, Hayato Maeda, Kazuo Miyashita, Takuji Tanaka, Shingo Miyamoto, Michihiro Mutoh
Fucoxanthinol (FuOH), an intestinal metabolite form of fucoxanthin (Fx) isolated from marine algae, is known to possess multiple health benefits, such as prevention of human cancer. However, there is little available information about the effects of FuOH on colorectal cancer stem cells (CCSCs) and their contribution to drug resistance, tumorigenesis and cancer recurrence. In the present study, we investigated the anti-proliferative effect of FuOH on two putative CCSCs, CD44(high)/EpCAM(high) cells and colonospheres (Csps) formed by HT-29 human colorectal cancer cells, and the suppressive effects of FuOH on the growth of xenografted tumor...
July 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28750733/separation-and-identification-of-fatty-acid-esters-of-algal-carotenoid-metabolites-in-the-freshwater-mussel-dreissena-bugensis-by-liquid-chromatography-with-uv-visible-wavelength-and-mass-spectrometric-detectors-in-series
#7
Maxime C Bridoux, Monika Sobiechowska, Robert G Briggs, Alicia Pérez-Fuentetaja, Katherine T Alben
LC with photodiode array and APCI-ion trap mass spectrometry has made it possible to tentatively identify 76 carotenyl fatty acid esters (cFAEs) in solvent extracts from Dreissena bugensis, collected from Lake Erie: 16 mono- and 33 diFAEs of fucoxanthinol (FOH), and 27 diFAEs of mactraxanthin (MX). FOH and MX, previously identified in cFAE hydrolysates, were confirmed as parent carotenoids of the cFAEs, and as primary metabolites of fucoxanthin and violaxanthin, respectively, derived from diatoms and chlorophytes in the dreissenids' diet...
July 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28694655/antioxidant-dietary-approach-in-treatment-of-fatty-liver-new-insights-and-updates
#8
REVIEW
Alessandra Ferramosca, Mariangela Di Giacomo, Vincenzo Zara
Non-alcoholic fatty liver disease (NAFLD) is a common clinicopathological condition, encompassing a range of conditions caused by lipid deposition within liver cells. To date, no approved drugs are available for the treatment of NAFLD, despite the fact that it represents a serious and growing clinical problem in the Western world. Identification of the molecular mechanisms leading to NAFLD-related fat accumulation, mitochondrial dysfunction and oxidative balance impairment facilitates the development of specific interventions aimed at preventing the progression of hepatic steatosis...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28677008/pigment-structure-in-the-violaxanthin-chlorophyll-a-binding-protein-vcp
#9
Manuel J Llansola-Portoles, Radek Litvin, Cristian Ilioaia, Andrew A Pascal, David Bina, Bruno Robert
Resonance Raman spectroscopy was used to evaluate pigment-binding site properties in the violaxanthin-chlorophyll-a-binding protein (VCP) from Nannochloropsis oceanica. The pigments bound to this antenna protein are chlorophyll-a, violaxanthin, and vaucheriaxanthin. The molecular structures of bound Chl-a molecules are discussed with respect to those of the plant antenna proteins LHCII and CP29, the crystal structures of which are known. We show that three populations of carotenoid molecules are bound by VCP, each of which is in an all-trans configuration...
July 4, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28669083/quenching-of-chlorophyll-triplet-states-by-carotenoids-in-algal-light-harvesting-complexes-related-to-fucoxanthin-chlorophyll-protein
#10
Petro Khoroshyy, David Bína, Zdenko Gardian, Radek Litvín, Jan Alster, Jakub Pšenčík
We have used time-resolved absorption and fluorescence spectroscopy with nanosecond resolution to study triplet energy transfer from chlorophylls to carotenoids in a protective process that prevents the formation of reactive singlet oxygen. The light-harvesting complexes studied were isolated from Chromera velia, belonging to a group Alveolata, and Xanthonema debile and Nannochloropsis oceanica, both from Stramenopiles. All three light-harvesting complexes are related to fucoxanthin-chlorophyll protein, but contain only chlorophyll a and no chlorophyll c...
July 1, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28642129/fucoxanthin-inhibits-profibrotic-protein-expression-in-vitro-and-attenuates-bleomycin-induced-lung-fibrosis-in-vivo
#11
Sun Young Ma, Won Sun Park, Dae-Sung Lee, Grace Choi, Mi-Jin Yim, Jeong Min Lee, Won-Kyo Jung, Sae Gwang Park, Su-Kil Seo, Sung Jae Park, Il Yong Han, Yung Hyun Choi, Il-Whan Choi
Pulmonary fibrosis, a potentially fatal disease, results from acute and chronic interstitial lung diseases. Fucoxanthin (Fx), a carotenoid found in brown seaweed, shows a wide range of pharmacological activities. In this study, we investigated the antifibrotic effects of fucoxanthin and their underlying molecular mechanisms in transforming growth factor-beta1 (TGF-β1)-stimulated human pulmonary fibroblasts (HPFs). Thus, the effects of Fx on TGF-β1-induced expression of fibrotic factors, such as alpha-smooth muscle actin (α-SMA), type 1 collagen, fibronectin, and interleukin-6 (IL-6), in HPFs were investigated...
September 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28636682/excited-state-characterization-of-carbonyl-containing-carotenoids-a-comparison-between-single-and-multireference-descriptions
#12
Riccardo Spezia, Stefan Knecht, Benedetta Mennucci
Carotenoids can play multiple roles in biological photoreceptors thanks to their rich photophysics. In the present work, we have investigated six of the most common carbonyl containing carotenoids: echinenone, canthaxanthin, astaxanthin, fucoxanthin, capsanthin and capsorubin. Their excitation properties are investigated by means of a hybrid density functional theory (DFT) and multireference configuration interaction (MRCI) approach to elucidate the role of the carbonyl group: the bright transition is of ππ* character, as expected, but the presence of a C[double bond, length as m-dash]O moiety reduces the energy of nπ* transitions which may become closer to the ππ* transition, in particular as the conjugation chain decreases...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28627163/molecular-structures-and-functions-of-chlorophylls-a-esterified-with-geranylgeranyl-dihydrogeranylgeranyl-and-tetrahydrogeranylgeranyl-groups-at-the-17-propionate-residue-in-a-diatom-chaetoceros-calcitrans
#13
Tadashi Mizoguchi, Megumi Isaji, Nami Yamano, Jiro Harada, Ritsuko Fujii, Hitoshi Tamiaki
The 17-propionate ester group of chlorophyll(Chl)-a in some oxygenic phototrophs was investigated using HPLC. Chls-a esterified with partially dehydrogenated forms of a phytyl group were found in fully grown cells of a diatom, Chaetoceros calcitrans: geranylgeranyl (GG), dihydrogeranylgeranyl (DHGG), and tetrahydrogeranylgeranyl (THGG). Chls-a bearing such esterifying groups were reported to be found only in greening processes of higher plants, and thus these Chls-a have been thought to be biosynthetic precursors for phytylated Chl-a...
July 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28620480/reduction-of-hba1c-levels-by-fucoxanthin-enriched-akamoku-oil-possibly-involves-the-thrifty-allele-of-uncoupling-protein-1-ucp1-a-randomised-controlled-trial-in-normal-weight-and-obese-japanese-adults
#14
Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M Ito, Yasuo Kokai
Lifestyle-related problems are becoming a major health threat in East Asian countries. Therefore, finding an efficacious nutraceutical for this population is important. One candidate is fucoxanthin (Fx), a carotenoid abundantly found in edible brown seaweed that has been associated with a number of valuable health-promoting benefits. Unfortunately, clinical studies of Fx are limited. In the present study, we aimed to evaluate the effects of Fx on obesity-related parameters in Japanese subjects harbouring an SNP associated with lifestyle-related problems...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28578538/phospholipids-of-new-zealand-edible-brown-algae
#15
Mikhail Vyssotski, Kirill Lagutin, Andrew MacKenzie, Kevin Mitchell, Dawn Scott
Edible brown algae have attracted interest as a source of beneficial allenic carotenoid fucoxanthin, and glyco- and phospholipids enriched in polyunsaturated fatty acids. Unlike green algae, brown algae contain no or little phosphatidylserine, possessing an unusual aminophospholipid, phosphatidyl-O-[N-(2-hydroxyethyl) glycine], PHEG, instead. When our routinely used technique of (31)P-NMR analysis of phospholipids was applied to the samples of edible New Zealand brown algae, a number of signals corresponding to unidentified phosphorus-containing compounds were observed in total lipids...
July 2017: Lipids
https://www.readbyqxmd.com/read/28478680/fucoxanthin-inhibits-%C3%AE-amyloid-assembly-and-attenuates-%C3%AE-amyloid-oligomer-induced-cognitive-impairments
#16
Siying Xiang, Fufeng Liu, Jiajia Lin, Huixin Chen, Chunhui Huang, Liping Chen, Yiying Zhou, Luying Ye, Ke Zhang, Jiukai Jin, Jiacheng Zhen, Chuang Wang, Shan He, Qinwen Wang, Wei Cui, Jinrong Zhang
β-Amyloid (Aβ) can form aggregates through self-assembly and produce neurotoxicity in the early stage of Alzheimer's disease (AD). Therefore, the inhibition of Aβ assembly is considered as the primary target for AD therapy. In this study, we reported that fucoxanthin, a marine carotenoid, potently reduced the formation of Aβ fibrils and oligomers. Moreover, the fucoxanthin-triggered modification significantly reduced the neurotoxicity of Aβ oligomers in vitro. Molecular dynamics simulation analysis further revealed a hydrophobic interaction between fucoxanthin and Aβ peptide, which might prevent the conformational transition and self-assembly of Aβ...
May 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28469544/fucoxanthin-prevents-h2o2-induced-neuronal-apoptosis-via-concurrently-activating-the-pi3-k-akt-cascade-and-inhibiting-the-erk-pathway
#17
Jie Yu, Jia-Jia Lin, Rui Yu, Shan He, Qin-Wen Wang, Wei Cui, Jin-Rong Zhang
Background: As a natural carotenoid abundant in chloroplasts of edible brown algae, fucoxanthin possesses various health benefits, including anti-oxidative activity in particular. Objective: In the present study, we studied whether fucoxanthin protected against hydrogen peroxide (H2O2)-induced neuronal apoptosis. Design: The neuroprotective effects of fucoxanthin on H2O2-induced toxicity were studied in both SH-SY5Y cells and primary cerebellar granule neurons. Results: Fucoxanthin significantly protected against H2O2-induced neuronal apoptosis and intracellular reactive oxygen species...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28429775/fucoxanthin-provides-neuroprotection-in-models-of-traumatic-brain-injury-via-the-nrf2-are-and-nrf2-autophagy-pathways
#18
Li Zhang, Handong Wang, Youwu Fan, Yongyue Gao, Xiang Li, Zhigang Hu, Ke Ding, Yujie Wang, Xiaoliang Wang
Fucoxanthin is abundant in seaweed and is considered as a powerful antioxidant. It has been proposed to possess anti-cancer, anti-obesity and anti-diabetes effects. However, its roles in brain injury models have not been fully understood. The objective of this study was to investigate the neuroprotection of fucoxanthin in models of traumatic brain injury (TBI) and the role of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant-response element (ARE) and Nrf2-autophagy pathways in the putative neuroprotection...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389351/enhancing-colour-and-oxidative-stabilities-of-reduced-nitrite-turkey-meat-sausages-during-refrigerated-storage-using-fucoxanthin-purified-from-the-tunisian-seaweed-cystoseira-barbata
#19
Sabrine Sellimi, Ghada Ksouda, Abdelkarim Benslima, Rim Nasri, Marguerite Rinaudo, Moncef Nasri, Mohamed Hajji
The present study investigated the angiotensin-I converting enzyme (ACE) inhibitory activity and the antioxidant properties, in vitro and in cured meat sausages containing reduced levels of sodium nitrite, of fucoxanthin extracted from the Tunisian brown seaweed Cystoseira barbata (CBFX). Results revealed that CBFX exhibited great scavenging activities against DPPH free radicals (EC50 = 136 μg/ml), peroxyl radicals in the linoleate-β-carotene system (EC50 = 43 μg/ml) and hydroxyl radicals generated by Fenton reaction (DNA nicking assay)...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28387741/effects-of-low-molecular-weight-fucoidan-and-high-stability-fucoxanthin-on-glucose-homeostasis-lipid-metabolism-and-liver-function-in-a-mouse-model-of-type-ii-diabetes
#20
Hong-Ting Victor Lin, Yu-Chi Tsou, Yu-Ting Chen, Wen-Jung Lu, Pai-An Hwang
The combined effects of low-molecular-weight fucoidan (LMF) and fucoxanthin (Fx) in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db/db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism...
April 7, 2017: Marine Drugs
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