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Fucoxanthin

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https://www.readbyqxmd.com/read/28636682/excited-state-characterization-of-carbonyl-containing-carotenoids-a-comparison-between-single-and-multireference-descriptions
#1
Riccardo Spezia, Stefan Knecht, Benedetta Mennucci
Carotenoids can play multiple roles in biological photoreceptors thanks to their rich photophysics. In the present work, we have investigated six of the most common carbonyl containing carotenoids: echinenone, canthaxanthin, astaxanthin, fucoxanthin, capsanthin and capsorubin. Their excitation properties are investigated by means of a hybrid density functional theory (DFT) and multireference configuration interaction (MRCI) approach to elucidate the role of the carbonyl group: the bright transition is of ππ* character, as expected, but the presence of a C[double bond, length as m-dash]O moiety reduces the energy of nπ* transitions which may become closer to the ππ* transition, in particular as the conjugation chain decreases...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28627163/molecular-structures-and-functions-of-chlorophylls-a-esterified-with-geranylgeranyl-dihydrogeranylgeranyl-and-tetrahydrogeranylgeranyl-groups-at-the-17-propionate-residue-in-a-diatom-chaetoceros-calcitrans
#2
Tadashi Mizoguchi, Megumi Isaji, Nami Yamano, Jiro Harada, Ritsuko Fujii, Hitoshi Tamiaki
The 17-propionate ester group of chlorophyll(Chl)-a in some oxygenic phototrophs was investigated using HPLC. Chls-a esterified with partially dehydrogenated forms of a phytyl group were found in fully grown cells of a diatom, Chaetoceros calcitrans: geranylgeranyl (GG), dihydrogeranylgeranyl (DHGG), and tetrahydrogeranylgeranyl (THGG). Chls-a bearing such esterifying groups were reported to be found only in greening processes of higher plants, and thus these Chls-a have been thought to be biosynthetic precursors for phytylated Chl-a...
June 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28620480/reduction-of-hba1c-levels-by-fucoxanthin-enriched-akamoku-oil-possibly-involves-the-thrifty-allele-of-uncoupling-protein-1-ucp1-a-randomised-controlled-trial-in-normal-weight-and-obese-japanese-adults
#3
Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M Ito, Yasuo Kokai
Lifestyle-related problems are becoming a major health threat in East Asian countries. Therefore, finding an efficacious nutraceutical for this population is important. One candidate is fucoxanthin (Fx), a carotenoid abundantly found in edible brown seaweed that has been associated with a number of valuable health-promoting benefits. Unfortunately, clinical studies of Fx are limited. In the present study, we aimed to evaluate the effects of Fx on obesity-related parameters in Japanese subjects harbouring an SNP associated with lifestyle-related problems...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28578538/phospholipids-of-new-zealand-edible-brown-algae
#4
Mikhail Vyssotski, Kirill Lagutin, Andrew MacKenzie, Kevin Mitchell, Dawn Scott
Edible brown algae have attracted interest as a source of beneficial allenic carotenoid fucoxanthin, and glyco- and phospholipids enriched in polyunsaturated fatty acids. Unlike green algae, brown algae contain no or little phosphatidylserine, possessing an unusual aminophospholipid, phosphatidyl-O-[N-(2-hydroxyethyl) glycine], PHEG, instead. When our routinely used technique of (31)P-NMR analysis of phospholipids was applied to the samples of edible New Zealand brown algae, a number of signals corresponding to unidentified phosphorus-containing compounds were observed in total lipids...
June 3, 2017: Lipids
https://www.readbyqxmd.com/read/28478680/fucoxanthin-inhibits-%C3%AE-amyloid-assembly-and-attenuates-%C3%AE-amyloid-oligomer-induced-cognitive-impairments
#5
Siying Xiang, Fufeng Liu, Jiajia Lin, Huixin Chen, Chunhui Huang, Liping Chen, Yiying Zhou, Luying Ye, Ke Zhang, Jiukai Jin, Jiacheng Zhen, Chuang Wang, Shan He, Qinwen Wang, Wei Cui, Jinrong Zhang
β-Amyloid (Aβ) can form aggregates through self-assembly and produce neurotoxicity in the early stage of Alzheimer's disease (AD). Therefore, the inhibition of Aβ assembly is considered as the primary target for AD therapy. In this study, we reported that fucoxanthin, a marine carotenoid, potently reduced the formation of Aβ fibrils and oligomers. Moreover, the fucoxanthin-triggered modification significantly reduced the neurotoxicity of Aβ oligomers in vitro. Molecular dynamics simulation analysis further revealed a hydrophobic interaction between fucoxanthin and Aβ peptide, which might prevent the conformational transition and self-assembly of Aβ...
May 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28469544/fucoxanthin-prevents-h2o2-induced-neuronal-apoptosis-via-concurrently-activating-the-pi3-k-akt-cascade-and-inhibiting-the-erk-pathway
#6
Jie Yu, Jia-Jia Lin, Rui Yu, Shan He, Qin-Wen Wang, Wei Cui, Jin-Rong Zhang
Background: As a natural carotenoid abundant in chloroplasts of edible brown algae, fucoxanthin possesses various health benefits, including anti-oxidative activity in particular. Objective: In the present study, we studied whether fucoxanthin protected against hydrogen peroxide (H2O2)-induced neuronal apoptosis. Design: The neuroprotective effects of fucoxanthin on H2O2-induced toxicity were studied in both SH-SY5Y cells and primary cerebellar granule neurons. Results: Fucoxanthin significantly protected against H2O2-induced neuronal apoptosis and intracellular reactive oxygen species...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28429775/fucoxanthin-provides-neuroprotection-in-models-of-traumatic-brain-injury-via-the-nrf2-are-and-nrf2-autophagy-pathways
#7
Li Zhang, Handong Wang, Youwu Fan, Yongyue Gao, Xiang Li, Zhigang Hu, Ke Ding, Yujie Wang, Xiaoliang Wang
Fucoxanthin is abundant in seaweed and is considered as a powerful antioxidant. It has been proposed to possess anti-cancer, anti-obesity and anti-diabetes effects. However, its roles in brain injury models have not been fully understood. The objective of this study was to investigate the neuroprotection of fucoxanthin in models of traumatic brain injury (TBI) and the role of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant-response element (ARE) and Nrf2-autophagy pathways in the putative neuroprotection...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389351/enhancing-colour-and-oxidative-stabilities-of-reduced-nitrites-turkey-meat-sausages-during-refrigerated-storage-using-fucoxanthin-purified-from-the-tunisian-seaweed-cystoseira-barbata
#8
Sabrine Sellimi, Ghada Ksouda, Abdelkarim Ben Slima, Rim Nasri, Marguerite Rinaudo, Moncef Nasri, Mohamed Hajji
The present study investigated the angiotensin-I converting enzyme (ACE) inhibitory activity and the antioxidant properties, in vitro and in cured meat sausages containing reduced levels of sodium nitrites, of fucoxanthin purified from the Tunisian brown seaweed Cystoseira barbata (CBFX). Results revealed that CBFX exhibited great scavenging activities against DPPH free radicals (EC50 = 136 μg/ml), peroxyl radicals in the linoleate-β-carotene system (EC50 = 43 μg/ml) and hydroxyl radicals generated by Fenton reaction (DNA nicking assay)...
April 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28387741/effects-of-low-molecular-weight-fucoidan-and-high-stability-fucoxanthin-on-glucose-homeostasis-lipid-metabolism-and-liver-function-in-a-mouse-model-of-type-ii-diabetes
#9
Hong-Ting Victor Lin, Yu-Chi Tsou, Yu-Ting Chen, Wen-Jung Lu, Pai-An Hwang
The combined effects of low-molecular-weight fucoidan (LMF) and fucoxanthin (Fx) in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db/db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism...
April 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28382818/effect-of-isomerization-on-excited-state-dynamics-of-carotenoid-fucoxanthin
#10
Valentyna Kuznetsova, Pavel Chábera, Radek Litvín, Tomáš Polívka, Marcel Fuciman
Ultrafast transient absorption spectroscopy and single-wavelength anisotropy measurements were used to study the effect of isomerization on the excited-state properties of fucoxanthin in polar and nonpolar solvents. The excitation wavelengths were 477 nm for all-trans-fucoxanthin, and 333 and 477 nm for cis-fucoxanthin. All transient absorption spectra of the fucoxanthin isomers in polar solvents show intramolecular charge transfer (ICT) state features, typical for carbonyl carotenoids. Global analysis of the data requires an additional fitting component, originated from the presence of blue and red forms of fucoxanthin in a polar protic solvent...
May 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28373414/antitumor-and-cancer-preventative-function-of-fucoxanthin-a-marine-carotenoid
#11
REVIEW
Yoshiko Satomi
Fucoxanthin is a marine carotenoid mainly found in brown seaweeds. Its antitumor and cancer-preventative function has been extensively investigated. Investigations have indicated that fucoxanthin and its metabolite fucoxanthinol induce G1 cell-cycle arrest and apoptosis in various cell lines and can inhibit cancer development in animal models. It is imperative that the underlying mechanism of action of fucoxanthin be elucidated in order to facilitate the development of cancer-prevention strategies in humans...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28294216/strategies-to-enhance-the-excitation-energy-transfer-efficiency-in-a-light-harvesting-system-using-the-intra-molecular-charge-transfer-character-of-carotenoids
#12
Nao Yukihira, Yuko Sugai, Masazumi Fujiwara, Daisuke Kosumi, Masahiko Iha, Kazuhiko Sakaguchi, Shigeo Katsumura, Alastair T Gardiner, Richard J Cogdell, Hideki Hashimoto
Fucoxanthin is a carotenoid that is mainly found in light-harvesting complexes from brown algae and diatoms. Due to the presence of a carbonyl group attached to polyene chains in polar environments, excitation produces an excited intra-molecular charge transfer. This intra-molecular charge transfer state plays a key role in the highly efficient (∼95%) energy-transfer from fucoxanthin to chlorophyll a in the light-harvesting complexes from brown algae. In purple bacterial light-harvesting systems the efficiency of excitation energy-transfer from carotenoids to bacteriochlorophylls depends on the extent of conjugation of the carotenoids...
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28239063/fatty-acid-and-lipid-class-composition-of-the-microalga-phaeodactylum-tricornutum
#13
Yu-Hong Yang, Lei Du, Masashi Hosokawa, Kazuo Miyashita, Yume Kokubun, Hisayoshi Arai, Hiroyuki Taroda
n-3 Polyunsaturated fatty acids (PUFAs) are essential for the prevention and/or risk reduction of some diseases, including cardiovascular diseases and cancer. Therefore, PUFAs-rich marine microalgae have received considerable research attention. The diatom Phaeodactylum tricornutum, a rich source of lipids and fucoxanthin, has commercial applications in the food and pharmaceutical industries. In this study, the lipid class composition and fatty acid distribution in P. tricornutum under high-density and scale-up cultivation were investigated by thin-layer chromatography and gas chromatography...
April 3, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28231315/functional-xanthophyll-cycle-and-pigment-content-of-a-kleptoplastic-benthic-foraminifer-haynesina-germanica
#14
Thierry Jauffrais, Bruno Jesus, Vona Méléder, Emmanuelle Geslin
Some shallow water benthic foraminifera are able to retain functional chloroplasts (kleptoplasts) from their food source, i.e. diatoms. Here we assessed the functionality of the kleptoplast xanthophyll cycle (XC, i.e. the main diatom short-term photo-regulation mechanism) and we surveyed Haynesina germanica kleptoplast pigment composition over time and at different light regimes. Six common diatom lipophilic pigments were detected, two chlorophylls (Chl a, Chl c) and four carotenoids (fucoxanthin and by-products, diadinoxanthin, diatoxanthin and β-carotene), the same pigment profile as the diatom species frequently isolated at the sampling site...
2017: PloS One
https://www.readbyqxmd.com/read/28212270/antitumor-effects-of-laminaria-extract-fucoxanthin-on-lung-cancer
#15
ChengHan Mei, ShunChang Zhou, Lin Zhu, JiaXiong Ming, FanDian Zeng, Rong Xu
Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumulating evidence suggests anti-proliferative effects of FX on many cancer cell lines including NSCLCs, but the detailed mechanisms remain unclear. In the present investigation, we confirmed molecular mechanisms and in vivo anti-lung cancer effect of FX at the first time...
February 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28192486/ocean-acidification-modulates-expression-of-genes-and-physiological-performance-of-a-marine-diatom
#16
Yahe Li, Shufang Zhuang, Yaping Wu, Honglin Ren, Fangyi Chen, Xin Lin, Kejian Wang, John Beardall, Kunshan Gao
Ocean Acidification (OA) is known to affect various aspects of physiological performances of diatoms, but little is known about the underlining molecular mechanisms involved. Here, we show that in the model diatom Phaeodactylum tricornutum, the expression of key genes associated with photosynthetic light harvesting as well as those encoding Rubisco, carbonic anhydrase, NADH dehydrogenase and nitrite reductase, are modulated by OA (1000 μatm, pHnbs 7.83). Growth and photosynthetic carbon fixation were enhanced by elevated CO2...
2017: PloS One
https://www.readbyqxmd.com/read/28070550/hplc-fucoxanthin-profiles-of-a-microalga-a-macroalga-and-a-pure-fucoxanthin-standard
#17
Su Chern Foo, Fatimah Md Yusoff, Maznah Ismail, Mahiran Basri, Sook Kun Yau, Nicholas M H Khong, Kim Wei Chan, Mahdi Ebrahimi
Data in this article illustrate representative fucoxanthin chromatograms of a microalga, Chaetoceros calcitrans; a macroalga, Saccharina japonica and; a pure fucoxanthin standard. High performance liquid chromatography (HPLC) eluted fucoxanthin at the 7.008±0.024th min. This data article refers to the research article ''Antioxidant capacities of fucoxanthin-producing algae as influenced by their carotenoid and phenolic contents'' Foo et al. [1]; where a more comprehensive data interpretation and analysis is explained...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28039566/the-structure-of-fcpb-a-light-harvesting-complex-in-the-diatom-cyclotella-meneghiniana
#18
Anja Röding, Egbert Boekema, Claudia Büchel
Diatoms possess fucoxanthin chlorophyll proteins (FCP) as light-harvesting systems. These membrane intrinsic proteins bind fucoxanthin as major carotenoid and Chl c as accessory chlorophyll. The relatively high sequence homology to higher plant light-harvesting complex II gave rise to the assumption of a similar overall structure. From centric diatoms like Cyclotella meneghiniana, however, two major FCP complexes can be isolated. FCPa, composed of Fcp2 and Fcp6 subunits, was demonstrated to be trimeric, whereas FCPb, known to contain Fcp5 polypeptides, is of higher oligomeric state...
December 30, 2016: Photosynthesis Research
https://www.readbyqxmd.com/read/28019019/two-southern-ocean-diatoms-are-more-sensitive-to-ocean-acidification-and-changes-in-irradiance-than-the-prymnesiophyte-phaeocystis-antarctica
#19
Scarlett Trimborn, Silke Thoms, Tina Brenneis, Jasmin P Heiden, Sara Beszteri, Kai Bischof
To better understand the impact of ocean acidification (OA) and changes in light availability on Southern Ocean phytoplankton physiology, we investigated the effects of pCO2 (380 and 800 µatm) in combination with low and high irradiance (20 or 50 and 200 µmol photons m(-2)  s(-1) ) on growth, particulate organic carbon (POC) fixation and photophysiology in the three ecologically relevant species Chaetoceros debilis, Fragilariopsis kerguelensis and Phaeocystis antarctica. Irrespective of the light scenario, neither growth nor POC per cell was stimulated by OA in any of the tested species and the two diatoms even displayed negative responses in growth (e...
June 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/27989819/detachment-of-the-fucoxanthin-chlorophyll-a-c-binding-protein-fcp-antenna-is-not-involved-in-the-acclimative-regulation-of-photoprotection-in-the-pennate-diatom-phaeodactylum-tricornutum
#20
Vasco Giovagnetti, Alexander V Ruban
When grown under intermittent light (IL), the pennate diatom Phaeodactylum tricornutum forms 'super' non-photochemical fluorescence quenching (NPQ) in response to excess light. The current model of diatom NPQ mechanism involves two quenching sites, one of which detaches from photosystem II reaction centres (RCIIs) and aggregates into oligomeric complexes. Here we addressed how antenna reorganisation controls NPQ kinetics in P. tricornutum cells grown under continuous light (CL) and IL. Overall, IL acclimation induced: (i) reorganisation of chloroplasts, containing greater pigment pools without a strongly enhanced operation of the xanthophyll cycle, and (ii) 'super NPQ' causing a remarkable reduction of the chlorophyll excited state lifetime at Fm'...
March 2017: Biochimica et Biophysica Acta
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