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Fucoxanthin

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https://www.readbyqxmd.com/read/28212270/antitumor-effects-of-laminaria-extract-fucoxanthin-on-lung-cancer
#1
ChengHan Mei, ShunChang Zhou, Lin Zhu, JiaXiong Ming, FanDian Zeng, Rong Xu
Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumulating evidence suggests anti-proliferative effects of FX on many cancer cell lines including NSCLCs, but the detailed mechanisms remain unclear. In the present investigation, we confirmed molecular mechanisms and in vivo anti-lung cancer effect of FX at the first time...
February 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28192486/ocean-acidification-modulates-expression-of-genes-and-physiological-performance-of-a-marine-diatom
#2
Yahe Li, Shufang Zhuang, Yaping Wu, Honglin Ren, Fangyi Chen, Xin Lin, Kejian Wang, John Beardall, Kunshan Gao
Ocean Acidification (OA) is known to affect various aspects of physiological performances of diatoms, but little is known about the underlining molecular mechanisms involved. Here, we show that in the model diatom Phaeodactylum tricornutum, the expression of key genes associated with photosynthetic light harvesting as well as those encoding Rubisco, carbonic anhydrase, NADH dehydrogenase and nitrite reductase, are modulated by OA (1000 μatm, pHnbs 7.83). Growth and photosynthetic carbon fixation were enhanced by elevated CO2...
2017: PloS One
https://www.readbyqxmd.com/read/28070550/hplc-fucoxanthin-profiles-of-a-microalga-a-macroalga-and-a-pure-fucoxanthin-standard
#3
Su Chern Foo, Fatimah Md Yusoff, Maznah Ismail, Mahiran Basri, Sook Kun Yau, Nicholas M H Khong, Kim Wei Chan, Mahdi Ebrahimi
Data in this article illustrate representative fucoxanthin chromatograms of a microalga, Chaetoceros calcitrans; a macroalga, Saccharina japonica and; a pure fucoxanthin standard. High performance liquid chromatography (HPLC) eluted fucoxanthin at the 7.008±0.024th min. This data article refers to the research article ''Antioxidant capacities of fucoxanthin-producing algae as influenced by their carotenoid and phenolic contents'' Foo et al. [1]; where a more comprehensive data interpretation and analysis is explained...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28039566/the-structure-of-fcpb-a-light-harvesting-complex-in-the-diatom-cyclotella-meneghiniana
#4
Anja Röding, Egbert Boekema, Claudia Büchel
Diatoms possess fucoxanthin chlorophyll proteins (FCP) as light-harvesting systems. These membrane intrinsic proteins bind fucoxanthin as major carotenoid and Chl c as accessory chlorophyll. The relatively high sequence homology to higher plant light-harvesting complex II gave rise to the assumption of a similar overall structure. From centric diatoms like Cyclotella meneghiniana, however, two major FCP complexes can be isolated. FCPa, composed of Fcp2 and Fcp6 subunits, was demonstrated to be trimeric, whereas FCPb, known to contain Fcp5 polypeptides, is of higher oligomeric state...
December 30, 2016: Photosynthesis Research
https://www.readbyqxmd.com/read/28019019/two-southern-ocean-diatoms-are-more-sensitive-to-ocean-acidification-and-changes-in-irradiance-than-the-prymnesiophyte-phaeocystis-antarctica
#5
Scarlett Trimborn, Silke Thoms, Tina Brenneis, Jasmin Pascale Heiden, Sara Beszteri, Kai Bischof
To better understand the impact of ocean acidification (OA) and changes in light availability on Southern Ocean phytoplankton physiology, we investigated the effects of pCO2 (380 and 800 µatm) in combination with low and high irradiance (20 or 50 and 200 µmol photons m(-2) s(-1) ) on growth, particulate organic carbon (POC) fixation and photophysiology in the three ecologically relevant species Chaetoceros debilis, Fragilariopsis kerguelensis and Phaeocystis antarctica. Irrespective of the light scenario, neither growth nor POC per cell was stimulated by OA in any of the tested species and the two diatoms even displayed negative responses in growth (e...
December 25, 2016: Physiologia Plantarum
https://www.readbyqxmd.com/read/27989819/detachment-of-the-fucoxanthin-chlorophyll-a-c-binding-protein-fcp-antenna-is-not-involved-in-the-acclimative-regulation-of-photoprotection-in-the-pennate-diatom-phaeodactylum-tricornutum
#6
Vasco Giovagnetti, Alexander V Ruban
When grown under intermittent light (IL), the pennate diatom Phaeodactylum tricornutum forms 'super' non-photochemical fluorescence quenching (NPQ) in response to excess light. The current model of diatom NPQ mechanism involves two quenching sites, one of which detaches from photosystem II reaction centres (RCIIs) and aggregates into oligomeric complexes. Here we addressed how antenna reorganisation controls NPQ kinetics in P. tricornutum cells grown under continuous light (CL) and IL. Overall, IL acclimation induced: (i) reorganisation of chloroplasts, containing greater pigment pools without a strongly enhanced operation of the xanthophyll cycle, and (ii) 'super NPQ' causing a remarkable reduction of the chlorophyll excited state lifetime at Fm'...
December 16, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27981801/natural-products-among-brown-algae-the-case-of-cystoseira-schiffneri-hamel-sargassaceae-phaeophyceae
#7
Abdelkader Ben Salem, Graziano Di Giuseppe, Andrea Anesi, Saoussen Hammami, Zine Mighri, Graziano Guella
A chemotaxonomic study on the marine brown alga Cystoseira schiffneri collected from the Tunisian marine coast allowed us to identify kjellmanianone (1) and a new isololiolide derivative named schiffnerilolide (2). The structure elucidation and the assignment of relative configurations of the isolated natural products were based on advanced mass spectrometric and nuclear magnetic resonance techniques. This outcome suggested a close phylogenetic relationship of Cystoseira schiffneri with brown algae belonging to genus Sargassum C...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27960297/preparation-of-fucoxanthin-loaded-nanoparticles-composed-of-casein-and-chitosan-with-improved-fucoxanthin-bioavailability
#8
Song Yi Koo, Il-Kyoon Mok, Cheol-Ho Pan, Sang Min Kim
To facilitate the utilization of fucoxanthin (FX), a valuable marine carotenoid, in the food industry, FX-loaded casein nanoparticles (FX-CN) and chitosan-coated FX-CN (FX-CS-CN) were developed using the FX-enriched fraction from Phaeodactylum tricornutum. Two nanoscale particles (237 ± 13 nm for FX-CN and 277 ± 26 nm for FX-CN-CN) with spherical and smooth surfaces showed over 71% encapsulation efficiency and polydispersity index (PDI) value of 0.31-0.39 in water. Owing to the chitosan coating, FX-CS-CN showed a positive zeta potential (24...
December 14, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27941599/marine-algae-as-a-potential-source-for-anti-obesity-agents
#9
REVIEW
Chu Wan-Loy, Phang Siew-Moi
Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects...
December 7, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27933547/anti-neuroinflammatory-effects-of-fucoxanthin-via-inhibition-of-akt-nf-%C3%AE%C2%BAb-and-mapks-ap-1-pathways-and-activation-of-pka-creb-pathway-in-lipopolysaccharide-activated-bv-2-microglial-cells
#10
Dong Zhao, Seung-Hwan Kwon, Yoon Sun Chun, Ming-Yao Gu, Hyun Ok Yang
Microglia play a critical role in controlling the homeostasis of the brain, but over-activated microglia secrete pro-inflammatory mediators and cytokines, which induce neuronal cell death. Fucoxanthin (Fx), a marine carotenoid, has demonstrated a variety of beneficial health effects. Despite accumulating evidence supporting the immune-modulating effects of Fx in vitro, the underlying signaling pathways remain unknown. In the present study, Fx dose-dependently inhibited the secretion of lipopolysaccharide (LPS)-induced pro-inflammatory mediators including interleukin (IL)-6, tumor necrosis factor (TNF)-α, reactive oxygen species (ROS), prostaglandin (PG) E2, and nitric oxide (NO) productions, and also suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzymes...
December 8, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27914891/antioxidant-capacities-of-fucoxanthin-producing-algae-as-influenced-by-their-carotenoid-and-phenolic-contents
#11
Su Chern Foo, Fatimah Md Yusoff, Maznah Ismail, Mahiran Basri, Sook Kun Yau, Nicholas M H Khong, Kim Wei Chan, Mahdi Ebrahimi
Natural antioxidants from sustainable sources are favoured to accommodate worldwide antioxidant demand. In addition to bioprospecting for natural and sustainable antioxidant sources, this study aimed to investigate the relationship between the bioactives (i.e. carotenoid and phenolic acids) and the antioxidant capacities in fucoxanthin-producing algae. Total carotenoid, phenolic acid, fucoxanthin contents and fatty acid profile of six species of algae (five microalgae and one macroalga) were quantified followed by bioactivity evaluation using four antioxidant assays...
January 10, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/27879659/innovative-alternative-technologies-to-extract-carotenoids-from-microalgae-and-seaweeds
#12
REVIEW
Mahesha M Poojary, Francisco J Barba, Bahar Aliakbarian, Francesco Donsì, Gianpiero Pataro, Daniel A Dias, Pablo Juliano
Marine microalgae and seaweeds (microalgae) represent a sustainable source of various bioactive natural carotenoids, including β-carotene, lutein, astaxanthin, zeaxanthin, violaxanthin and fucoxanthin. Recently, the large-scale production of carotenoids from algal sources has gained significant interest with respect to commercial and industrial applications for health, nutrition, and cosmetic applications. Although conventional processing technologies, based on solvent extraction, offer a simple approach to isolating carotenoids, they suffer several, inherent limitations, including low efficiency (extraction yield), selectivity (purity), high solvent consumption, and long treatment times, which have led to advancements in the search for innovative extraction technologies...
November 22, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27822308/advantageous-characteristics-of-the-diatom-chaetoceros-gracilis-as-a-sustainable-biofuel-producer
#13
Hiromi Tokushima, Natsuko Inoue-Kashino, Yukine Nakazato, Atsunori Masuda, Kentaro Ifuku, Yasuhiro Kashino
BACKGROUND: Diatoms have attracted interest as biofuel producers. Here, the contents of lipids and photosynthetic pigments were analyzed in a marine centric diatom, Chaetoceros gracilis. This diatom can be genetically engineered using our previously reported transformation technique and has a potential to produce valuable materials photosynthetically. Sustainable culture conditions for cost-effective production of biological materials under autotrophic conditions with atmospheric carbon dioxide were investigated in the laboratory...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27785684/erratum-to-investigation-of-the-s1-ict-equilibrium-in-fucoxanthin-by-ultrafast-pump-dump-probe-and-femtosecond-stimulated-raman-scattering-spectroscopy
#14
Kipras Redeckas, Vladislava Voiciuk, Mikas Vengris
No abstract text is available yet for this article.
January 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/27670751/assessment-of-antioxidant-activity-in-victorian-marine-algal-extracts-using-high-performance-thin-layer-chromatography-and-multivariate-analysis
#15
Snezana Agatonovic-Kustrin, David W Morton, Petar Ristivojević
The aim of this study was to develop and validate a rapid and simple high performance thin layer chromatographic (HPTLC) method to screen for antioxidant activity in algal samples. 16 algal species were collected from local Victorian beaches. Fucoxanthin, one of the most abundant marine carotenoids was quantified directly from the HPTLC plates before derivatization, while derivatization either with 2,2-diphenyl-1-picrylhydrazyl (DPPH) or ferric chloride (FeCl3) was used to analyze antioxidants in marine algae, based on their ability to scavenge non biological stable free radical (DPPH) or to chelate iron ions...
October 14, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27666345/identification-and-characterization-of-multiple-emissive-species-in-aggregated-minor-antenna-complexes
#16
Md Wahadoszamen, Erica Belgio, Md Ashiqur Rahman, Anjue Mane Ara, Alexander V Ruban, Rienk van Grondelle
Aggregation induced conformational change of light harvesting antenna complexes is believed to constitute one of the pathways through which photosynthetic organisms can safely dissipate the surplus of energy while exposed to saturating light. In this study, Stark fluorescence (SF) spectroscopy is applied to minor antenna complexes (CP24, CP26 and CP29) both in their light-harvesting and energy-dissipating states to trace and characterize different species generated upon energy dissipation through aggregation (in-vitro) induced conformational change...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27635322/rapid-induction-of-gfp-expression-by-the-nitrate-reductase-promoter-in-the-diatom-phaeodactylum-tricornutum
#17
Lili Chu, Daniela Ewe, Carolina Río Bártulos, Peter G Kroth, Ansgar Gruber
An essential prerequisite for a controlled transgene expression is the choice of a suitable promoter. In the model diatom Phaeodactylum tricornutum, the most commonly used promoters for trans-gene expression are the light dependent lhcf1 promoters (derived from two endogenous genes encoding fucoxanthin chlorophyll a/c binding proteins) and the nitrate dependent nr promoter (derived from the endogenous nitrate reductase gene). In this study, we investigated the time dependent expression of the green fluorescent protein (GFP) reporter under control of the nitrate reductase promoter in independently genetically transformed P...
2016: PeerJ
https://www.readbyqxmd.com/read/27590588/protective-and-therapeutic-effects-of-fucoxanthin-against-sunburn-caused-by-uv-irradiation
#18
Mio Matsui, Kosuke Tanaka, Naoki Higashiguchi, Hisato Okawa, Yoichi Yamada, Ken Tanaka, Soichiro Taira, Tomoko Aoyama, Misaki Takanishi, Chika Natsume, Yuuki Takakura, Norihisa Fujita, Takeshi Hashimoto, Takashi Fujita
Mild exposure to ultraviolet (UV) radiation is also harmful and hazardous to the skin and often causes a photosensitivity disorder accompanied by sunburn. To understand the action of UV on the skin we performed a microarray analysis to isolate UV-sensitive genes. We show here that UV irradiation promoted sunburn and downregulated filaggrin (Flg); fucoxanthin (FX) exerted a protective effect. In vitro analysis showed that UV irradiation of human dermal fibroblasts caused production of intracellular reactive oxygen species (ROS) without cellular toxicity...
September 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27527189/undaria-pinnatifida-and-fucoxanthin-ameliorate-lipogenesis-and-markers-of-both-inflammation-and-cardiovascular-dysfunction-in-an-animal-model-of-diet-induced-obesity
#19
Ameyalli Grasa-López, Ángel Miliar-García, Lucía Quevedo-Corona, Norma Paniagua-Castro, Gerardo Escalona-Cardoso, Elba Reyes-Maldonado, María-Eugenia Jaramillo-Flores
Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density...
August 3, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27504970/effects-of-nitrogen-availability-and-form-on-phytoplankton-growth-in-a-eutrophied-estuary-neuse-river-estuary-nc-usa
#20
Emily K Cira, Hans W Paerl, Michael S Wetz
Nitrogen availability and form are important controls on estuarine phytoplankton growth. This study experimentally determined the influence of urea and nitrate additions on phytoplankton growth throughout the growing season (March 2012, June 2011, August 2011) in a temperate, eutrophied estuary (Neuse River Estuary, North Carolina, USA). Photopigments (chlorophyll a and diagnostic photopigments: peridinin, fucoxanthin, alloxanthin, zeaxanthin, chlorophyll b) and microscopy-based cell counts were used as indicators of phytoplankton growth...
2016: PloS One
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