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Levobupivacaine

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https://www.readbyqxmd.com/read/29935387/redox-mechanism-of-levobupivacaine-cytostatic-effect-on-human-prostate-cancer-cells
#1
Caroline Jose, Etienne Hebert-Chatelain, Nivea Dias Amoedo, Emmanuel Roche, Emilie Obre, Didier Lacombe, Hamid Reza Rezvani, Philippe Pourquier, Karine Nouette-Gaulain, Rodrigue Rossignol
Anti-cancer effects of local anesthetics have been reported but the mode of action remains elusive. Here, we examined the bioenergetic and REDOX impact of levobupivacaine on human prostate cancer cells (DU145) and corresponding non-cancer primary human prostate cells (BHP). Levobupivacaine induced a combined inhibition of glycolysis and oxidative phosphorylation in cancer cells, resulting in a reduced cellular ATP production and consecutive bioenergetic crisis, along with reactive oxygen species generation...
May 31, 2018: Redox Biology
https://www.readbyqxmd.com/read/29924051/consort-epidural-dexmedetomidine-improves-gastrointestinal-motility-after-laparoscopic-colonic-resection-compared-with-morphine
#2
Qiuxia Wan, Wengang Ding, Xiaoguang Cui, Xianzhang Zeng
BACKGROUND: We have previously shown that epidural dexmedetomidine, when used as an adjunct to levobupivacaine for control of postoperative pain after open colonic resection, improves recovery of gastrointestinal motility compared with morphine. METHODS: Sixty patients undergoing laparoscopic colonic resection were enrolled and allocated randomly to treatment with dexmedetomidine (group D) or morphine (group M). Group D received an epidural loading dose of dexmedetomidine (5 mL, 0...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923955/lipid-emulsion-pretreatment-decreased-the-maximum-total-and-free-plasma-concentration-of-levobupivacaine-for-femoral-and-sciatic-nerve-block-in-below-knee-fracture-surgery
#3
Ying Chen, Jian Zhang, Zhe Chen, Quanguang Wang, Bing Li, Rujing Lai, Xuzhong Xu, Zhifang Cao, Lizhen Yu
BACKGROUND AND OBJECTIVES: Although intravenous lipid emulsion has been proved a powerful antidote for local anesthetic toxicity, there are few pharmacokinetic data on using lipid infusion as a pretreatment for other clinical applications. We assessed the influence of lipid pretreatment on the pharmacodynamics and pharmacokinetics of levobupivacaine. METHODS: Altogether, 12 patients undergoing below-knee surgery for a fracture were randomly assigned to 2 groups (6 patients per group): pretreatment with 1...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29914785/the-optimal-concentration-of-bupivacaine-and-levobupivacaine-for-labor-pain-management-using-patient-controlled-epidural-analgesia-a-double-blind-randomized-controlled-trial
#4
V Baliuliene, A Macas, K Rimaitis
BACKGROUND: The study aim was to evaluate the efficacy and safety of different low concentrations of two local anesthetics for labor analgesia using patient-controlled epidural analgesia. METHODS: A double-blind, randomized controlled trial recruiting healthy nulliparous women was conducted from 2014 to 2016. Epidural analgesia was provided using local anesthetic and fentanyl. Patients were allocated to six groups, according to the concentration of bupivacaine or levobupivacaine (0...
May 18, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29914426/effects-of-local-anesthetics-on-breast-cancer-cell-viability-and-migration
#5
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P Dilger, Jun Lin
BACKGROUND: Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Here, we present a comprehensive analysis of the effects of six common local anesthetics on two human breast cancer cell lines...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29910493/a-study-to-compare-caudal-levobupivacaine-tramadol-and-a-combination-of-both-in-paediatric-inguinal-hernia-surgeries
#6
Neelam Dogra, Rajat Dadheech, Mahipal Dhaka, Anupama Gupta
Background and Aims: Caudal block is a safe and simple method of pain relief in young children with the drawback of a short duration of analgesia which can be overcome by adding various adjuvants to the injected local anaesthetic. We compared the effects of caudal levobupivacaine, tramadol and a combination of both in paediatric patients undergoing inguinal herniotomy. Methods: A total of 78 children aged 1-7 years, planned for inguinal herniotomy were randomly allocated into three groups...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29884529/-effects-of-local-anesthetics-on-wound-healing
#7
Sevgi Kesici, Ugur Kesici, Hulya Ulusoy, Pelin Erturkuner, Aygen Turkmen, Oktay Arda
INTRODUCTION: Local anesthetic infiltration is used widely for post-operative analgesia in many situations. However the effects of local anesthetics on wound healing are not demonstrated clearly. This study planned to evaluate the effects of lidocaine, prilocaine, bupivacaine and levobupivacaine on wound healing, primarily on wound tensile strength and on collagen ultrastructure. METHODS: This study was conducted on male Sprague Dawley rats. On days 0, 8th, 15th, and 21st, all animals were weighed and received a preincisional subcutaneous infiltration of 3mL of a solution according the group...
June 5, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29868463/persistent-hypothermia-and-excessive-sweating-following-intrathecal-morphine-administration-in-a-teenage-boy-a-case-report
#8
Sara Ferraz, Telma Caria, Aline Vaz Da Silva, Maria Jose Candeias, Teresa Cenicante
Introduction: Opioids are used intrathecally to manage surgical pain. There are few reports of hypothermia after spinal morphine injection, none in the pediatric population. We present a teenager's case of mild hypothermia. Case Presentation: A 15-year-old boy was scheduled for elective abdominal laparotomy. General anesthesia was combined with spinal anesthesia, using levobupivacaine and morphine. In the recovery room, he presented a decreased tympanic temperature (34...
February 2018: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29808262/nalbuphine-as-an-adjuvant-to-0-25-levobupivacaine-in-ultrasound-guided-supraclavicular-block-provided-prolonged-sensory-block-and-similar-motor-block-durations-rct
#9
Bassant Mohamed Abdelhamid, Heba Omar
PURPOSE: Prolonged postoperative analgesia with early motor recovery for early rehabilitation is a challenge in regional block. The purpose of this study is to evaluate the effect of adding 20 mg nalbuphine to 25 ml of 0.25% levobupivacaine in supraclavicular brachial plexus block. METHODS: One hundred thirty-five (135) patients scheduled for hand and forearm surgeries with supraclavicular block were randomly allocated into three equal groups. Group L received 25 ml of 0...
May 28, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29784500/utility-of-percutaneous-catheters-for-local-anaesthetics-infusion-for-postoperative-pain-control-in-lumbar-arthrodesis-a-prospective-cohort-study
#10
F J Ortega-García, I García-Del-Pino, I Auñon-Martín, A J Carrascosa-Fernández
OBJECTIVE: To evaluate whether postoperative continuous wound infiltration of levobupivacaine through two submuscular catheters connected to two elastomeric pumps after lumbar instrumented arthrodesis is more effective than intravenous patient-controlled analgesia. MATERIAL AND METHODS: An observational, prospective cohorts study was carried out. The visual analogue scale, the need for additional rescue analgesia and the onset of adverse effects were recorded. RESULTS: Pain records measured with visual analogue scale scale were significantly lower in the 48hours postoperative record at rest (p=...
May 18, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29782453/a-robust-approach-to-implementing-fascia-iliaca-compartment-nerve-blocks-in-hip-fracture-patients
#11
Mark G Williams, Zachary Jeffery, Henry W Corner, John Charity, Marina Quantick, Natalie Sartin
BACKGROUND: A clear imperative exists to optimize the preoperative pain management of hip fracture patients. Increasingly, fascia iliaca compartment blocks (FICBs) are being effectively utilized as an adjunct to oral analgesia in the emergency department. PURPOSE: We investigated the feasibility, safety, and delivery rate when junior doctors and specialist nurses are trained in FICBs delivery, alongside the introduction of a step-by-step proforma. METHODS: We conducted a retrospective study of hip fractures patients presenting preinterventions (n = 138) between October and December 2014 and postinterventions (n = 246) between April and August 2015...
May 2018: Orthopaedic Nursing
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#12
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29768964/effects-of-combined-spinal-epidural-analgesia-on-first-stage-of-labor-a-cohort-study
#13
Silvia Poma, Luigia Scudeller, Chiara Verga, Giorgio Mirabile, Barbara Gardella, Federica Broglia, Maria Ciceri, Marinella Fuardo, Simona Pellicori, Maddalena Gerletti, Silvia Zizzi, Elena Masserini, Maria Paola Delmonte, Giorgio Antonio Iotti
BACKGROUND: Neuraxial anesthesia is considered as the gold standard in the control labor of pain. Its variants are epidural analgesia and combined spinal-epidural analgesia. Few studies, as yet, have investigated the duration of labor as a primary outcome. Some authors have suggested that combined spinal-epidural analgesia may reduce labor duration but at the moment the benefit of shortening labor is uncertain. The main aim of this study was to compare combined spinal-epidural with epidural analgesia in terms of their effect on duration of stage I labor, maternal, and neonatal outcomes...
May 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29738057/-a-comparison-of-transversus-abdominis-plane-block-guided-with-ultrasonography-and-local-anesthetic-infiltration-in-laparoscopic-cholecystectomy-operations
#14
Burhan Dost, Gülbin Yalçın Sezen, Abdulkadir İskender, Onur Özlü
OBJECTIVES: The aim of this study was to compare a transversus abdominis plane (TAP) block guided with ultrasound (USG) and local anesthetic infiltration (LAI) in terms of the intraoperative and postoperative analgesia efficiency, intraoperative opioid need, and side effects in cases of laparoscopic cholecystectomy. METHODS: A total of 75 patients classified as American Society of Anesthesiologists class I or II were included in this randomized, controlled, prospective study and divided into 3 groups...
April 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29725795/a-low-dose-of-three-local-anesthetic-solutions-for-interscalene-blockade-tested-by-thermal-quantitative-sensory-testing-a-randomized-controlled-trial
#15
Luc A Sermeus, Tom Schepens, Guy H Hans, Stuart G Morrison, Kristien Wouters, Margaretha B Breebaart, Carine J Smitz, Marcel P Vercauteren
This randomized double-blind controlled trial compared the block characteristics of three low-dose local anesthetics at different roots in an ultrasound-guided interscalene block, using thermal quantitative sensory testing for assessing the functioning of cutaneous small nerve fibres. A total of 37 adults scheduled to undergo shoulder arthroscopy were randomized to receive 5 mL of either 0.5% levobupivacaine with and without epinephrine 1/200,000 or 0.75% ropivacaine in a single-shot interscalene block. Thermal quantitative sensory testing was performed in the C4, C5, C6 and C7 dermatomes...
May 3, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29684982/intrathecal-levobupivacaine-versus-bupivacaine-for-inguinal-hernia-surgery-a-randomized-controlled-trial
#16
Ajay Singh, Anshu Gupta, Priyankar Kumar Datta, Maitree Pandey
BACKGROUND: Levobupivacaine is an attractive alternative to racemic bupivacaine for spinal anesthesia due to the lower potential for cardio-toxicity and faster recovery profile. This study was designed to compare isobaric levobupivacaine with hyperbaric racemic bupivacaine with respect to intraoperative quality of anesthesia and the postoperative recovery profile in patients undergoing inguinal hernia surgery. METHODS: A total of 100 American Society of Anesthesiologists 1 and 2 patients, aged 18-60 years, undergoing elective daycare unilateral inguinal hernia surgery, were randomized into two groups...
June 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29670395/bupivacaine-in-alginate-and-chitosan-nanoparticles-an-in-vivo-evaluation-of-efficacy-pharmacokinetics-and-local-toxicity
#17
Cíntia Maria Saia Cereda, Daniel Sebbe Mecatti, Juliana Zampoli Boava Papini, Diego Valério Bueno, Michelle Franz-Montan, Thalita Rocha, José Pedrazzoli Júnior, Eneida de Paula, Daniele Ribeiro de Araújo, Renato Grillo, Leonardo Fernandes Fraceto, Silvana Aparecida Calafatti, Giovana Radomille Tofoli
Objective: This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi®, a racemic bupivacaine (BVC) containing 25% dextrobupivacaine and 75% levobupivacaine. Methods: New Zealand White rabbits (n=6) received intraoral or intrathecal injections of BVC 0.5% or BVC 0.5%-loaded alginate-chitosan nanoparticles (BVCALG ). BVC plasma levels and pharmacokinetic parameters were determined in blood samples of these rabbits...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29657246/effects-of-three-forms-of-local-anesthesia-on-perioperative-fentanyl-induced-hyperalgesia
#18
Lu Chang, Fang Ye, Quehua Luo, Zewen Wang, Yimin Wang, Zhengyuan Xia, Haihua Shu
Both local infiltration analgesia (LIA) and nerve block are common analgesic modalities for pain relief after surgery. The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. Rats were injected with fentanyl (60 μg/kg) 4 times and received a plantar incision after the second injection or they received pre-incision LIA and sciatic nerve block (SNB) or post-incision LIA with levobupivacaine (0...
May 13, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29630033/a-randomized-comparison-between-interscalene-and-small-volume-supraclavicular-blocks-for-arthroscopic-shoulder-surgery
#19
Julián Aliste, Daniela Bravo, Diego Fernández, Sebastián Layera, Roderick J Finlayson, De Q Tran
BACKGROUND AND OBJECTIVES: This randomized trial compared ultrasound (US)-guided interscalene block (ISB) and small-volume supraclavicular block (SCB) for arthroscopic shoulder surgery. We hypothesized that SCB would provide equivalent analgesia to ISB 30 minutes after surgery without the risk of hemidiaphragmatic paralysis (HDP). METHODS: All patients received an US-guided intermediate cervical plexus block. In the ISB group, US-guided ISB was performed with 20 mL of levobupivacaine 0...
April 6, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29628855/editorial-commentary-on-using-dexamethasone-as-an-adjuvant-to-levobupivacaine-in-epidural-anesthesia-to-change-the-pain-intensity-and-duration-in-painless-labor
#20
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