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https://www.readbyqxmd.com/read/28102332/dynamic-modeling-of-uteroplacental-blood-flow-in-iugr-indicates-vortices-and-elevated-pressure-in-the-intervillous-space-a-pilot-study
#1
Christian J Roth, Eva Haeussner, Tanja Ruebelmann, Franz V Koch, Christoph Schmitz, Hans-Georg Frank, Wolfgang A Wall
Ischemic placental disease is a concept that links intrauterine growth retardation (IUGR) and preeclampsia (PE) back to insufficient remodeling of uterine spiral arteries. The rheological consequences of insufficient remodeling of uterine spiral arteries were hypothesized to mediate the considerably later manifestation of obstetric disease. However, the micro-rheology in the intervillous space (IVS) cannot be examined clinically and rheological animal models of the human IVS do not exist. Thus, an in silico approach was implemented to provide in vivo inaccessible data...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077439/the-functional-expression-of-transient-receptor-potential-channels-in-the-mouse-endometrium
#2
Katrien De Clercq, Charlotte Van den Eynde, Aurélie Hennes, Rieta Van Bree, Thomas Voets, Joris Vriens
STUDY QUESTION: Does mouse endometrial epithelial cells and stromal cells have a similar transient receptor potential (TRP)-channel expression profile and to that found in the human endometrium? SUMMARY ANSWER: Mouse endometrial epithelial and stromal cells have a distinct TRP channel expression profile analogous to what has been found in human endometrium, and hence suggests the mouse a good model to investigate the role of TRP channels in reproduction. WHAT IS KNOWN ALREADY: An optimal intercellular communication between epithelial and stromal endometrial cells is crucial for successful reproduction...
January 6, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28066666/ct-guided-percutaneous-microwave-ablation-of-pulmonary-malignant-tumors
#3
Wei-Chun Ko, Yee-Fan Lee, Yi-Chang Chen, Ning Chien, Yu-Sen Huang, Yao-Hui Tseng, Jang-Ming Lee, Hsao-Hsun Hsu, Jin-Shing Chen, Yeun-Chung Chang
BACKGROUND: Microwave ablation (MWA) of lung tumors is a new approach for local tumor control. The purpose of this retrospective study was to evaluate the preliminary results of safety and efficacy of MWA with a dynamic frequency range (902-928 MHz) and power (10-32 W) for local tumor control of thoracic malignancies. METHODS: From December 1, 2013 to February 1, 2016, there were total 32 lung tumors among 15 patients (7 men, 8 women, age range 43-82 years, mean 57...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065695/perfusion-of-the-uterine-junctional-zone-in-nulliparous-and-primiparous-women-assessed-by-dce-mri-as-a-function-of-menstrual-cycle-and-hormonal-contraception
#4
L J Meylaerts, L Wijnen, M Bazot, M Grieten, W Ombelet, M Vandersteen
PURPOSE: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIAL AND METHODS: We performed pelvic 1.5T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26...
January 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27997081/uterine-focal-adhesion-dynamics-during-pregnancy-in-a-marsupial-sminthopsis-crassicaudata-dasyuridae
#5
Melanie K Laird, Michaela Turancova, Bronwyn M McAllan, Christopher R Murphy, Michael B Thompson
Alterations to the basal attachment points between the epithelium of the uterus and the underlying tissue in early pregnancy affect how easily the epithelium can be invaded by the implanting embryo. Attachment points- focal adhesions- disassemble to facilitate highly invasive implantation in rats, but species with less invasive implantation, including marsupials, may require different basal alterations for successful pregnancy. Here we used immunofluorescence microscopy and Western blotting to conduct the first study of basal plasma membrane dynamics in the uterus during marsupial pregnancy...
December 20, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27991743/vector-synthesis-high-resolution-electrocardiography-atrial-natriuretic-peptide-and-n-terminal-prohormone-brain-natriuretic-peptide-for-estimation-of-cardiac-load-in-pregnancy
#6
Shino Tanaka, Rie Oyama, Akimune Fukushima, Akihiko Kikuchi, Toru Sugiyama
AIM: We analyzed atrial natriuretic peptide (ANP), N-terminal pro-brain natriuretic natriuretic peptide (NT-proBNP) and vector synthesis high-resolution electrocardiography (ECG), to estimate cardiac load with circulatory dynamic change from pregnancy through the post-partum period. METHODS: The subjects were singleton pregnant women (n = 19), who were divided into three stages: stage 1, 34-36 weeks of gestation; stage 2, 2-6 post-partum days; and stage 3, 1-3 months after delivery...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27979878/implications-of-telomeres-and-telomerase-in-endometrial-pathology
#7
REVIEW
D K Hapangama, A Kamal, G Saretzki
BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, telomerase that maintains telomeres are under intensive scientific scrutiny. Both are involved in many human diseases including cancer, but also in ageing and chronic disease such as diabetes. Their intricate involvement in many cellular processes and pathways is being dynamically deciphered in many organs including the endometrium...
December 15, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27957583/longitudinal-growth-dynamics-of-term-symmetric-and-asymmetric-small-for-gestational-age-infants
#8
Harvinder Kaur, Anil Kumar Bhalla, Praveen Kumar
Background: Available information on auxological attainments of symmetric and asymmetric SGA (small for gestational age) infants presents conflicting views. The complete absence of longitudinal data on growth patterns of both types of Indian SGA infants prompted us to undertake this study. Aim: To study distance and velocity growth pattern of weight and crown-heel length (CHL) of symmetric and asymmetric SGA infants. Subjects & Methods: Weight and CHL amongst full-term 100 symmetric SGA, 100 asymmetric SGA and 100 AGA infants from upper socio-economic strata were mixed-longitudinally measured at birth, 1, 3, 6, 9 and 12 months in the Department of Pediatrics, PGIMER, Chandigarh, India...
November 23, 2016: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/27940158/inactivation-of-maternal-hif-1%C3%AE-at-mid-pregnancy-causes-placental-defects-and-deficits-in-oxygen-delivery-to-the-fetal-organs-under-hypoxic-stress
#9
Doreswamy Kenchegowda, Bryony Natale, Maria A Lemus, David R Natale, Steven A Fisher
A critical transition occurs near mid-gestation of mammalian pregnancy. Prior to this transition, low concentrations of oxygen (hypoxia) signaling through Hypoxia Inducible Factor (HIF) functions as a morphogen for the placenta and fetal organs. Subsequently, functional coupling of the placenta and fetal cardiovascular system for oxygen (O2) transport is required to support the continued growth and development of the fetus. Here we tested the hypothesis that Hif-1α is required in maternal cells for placental morphogenesis and function...
December 9, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27932897/effect-of-ovarian-endometrioma-on-uterine-and-ovarian-blood-flow-in-infertile-women
#10
Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27917295/circulating-human-papillomavirus-dna-detected-using-droplet-digital-pcr-in-the-serum-of-patients-diagnosed-with-early-stage-human-papillomavirus-associated-invasive-carcinoma
#11
Emmanuelle Jeannot, Véronique Becette, Maura Campitelli, Marie-Ange Calméjane, Emmanuelle Lappartient, Evelyne Ruff, Stéphanie Saada, Allyson Holmes, Dominique Bellet, Xavier Sastre-Garau
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours. Here we took advantage of the sensitive droplet digital PCR method to identify circulating human papillomavirus DNA in patients with human papillomavirus-associated carcinomas...
October 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27911818/planar-cell-polarity-signaling-in-the-uterus-directs-appropriate-positioning-of-the-crypt-for-embryo-implantation
#12
Jia Yuan, Jeeyeon Cha, Wenbo Deng, Amanda Bartos, Xiaofei Sun, Hsin-Yi Henry Ho, Jean-Paul Borg, Terry P Yamaguchi, Yingzi Yang, Sudhansu K Dey
Blastocyst implantation is a complex process requiring coordination of a dynamic sequence of embryo-uterine interactions. Blood vessels enter the uterus from the mesometrium, demarcating the uterus into mesometrial (M) and antimesometrial (AM) domains. Implantation occurs along the uterine longitudinal axis within specialized implantation chambers (crypts) that originate within the evaginations directed from the primary lumen toward the AM domain. The morphological orientation of crypts in rodent uteri was recognized more than a century ago, but the mechanism remained unknown...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27896299/basement-membrane-ultrastructure-and-component-localization-data-from-uterine-tissues-during-early-mouse-pregnancy
#13
Celestial R Jones-Paris, Sayan Paria, Taloa Berg, Juan Saus, Gautam Bhave, Bibhash C Paria, Billy G Hudson
Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua. Properties of BMs are maintained in homeostasis for most adult tissues. However, BM ultrastructure, composition, and localization are rapidly altered in select uterine tissues that are reprogrammed during pregnancy to enable early maternal-embryo interactions. Here, our data exhibit both static and dynamic BMs that were tracked in mouse uterine tissues during pre-, peri-, and postimplantation periods of pregnancy...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27871478/transendothelial-migration-of-human-umbilical-mesenchymal-stem-cells-across-uterine-endothelial-monolayers-junctional-dynamics-and-putative-mechanisms
#14
Neven A Ebrahim, Lopa Leach
INTRODUCTION: During pregnancy, fetal stem cells can transfer to the maternal circulation and participate in tissue repair. How they transmigrate across maternal endothelial barriers and whether they can subsequently influence maternal endothelial integrity is not known. METHODS: Mesenchymal stem cells (WJ-MSC) were isolated from Wharton's jelly and their interactions with human uterine microvascular endothelial cell (HUtMEC) monolayers, junctional occupancy and expression/phosphorylation of vascular endothelial (VE)- cadherin and vascular endothelial growth factor (VEGF-A) secretion was studied over 48h by real time, confocal microscopy, immunoblotting and ELISA...
December 2016: Placenta
https://www.readbyqxmd.com/read/27863551/in-vitro-cow-uterine-response-to-escherichia-coli-leukotrienes-and-cytokines
#15
A J Korzekwa, M Łupicka, B M- Socha, A A Szczepańska, E Piotrowicz, W Barański
The aim was to determine the dynamic profile of interactions between Escherichia coli (E. coli) and the actions of leukotrienes (LTs) and TNF and INFγ (cytokines) in the uterus in vitro. Uterine explants (N=6) were incubated for 2, 12 and 24h either as E. coli-treated (10(6)CFU) or non-treated and/or with: LTB4 and C4 (10(-6)M, for both LTs), LTs receptors antagonists (aLTR; 10(-6)M) and/or cytokines (each 10ng/ml). Toll Like Receptor 4 (TLR4) mRNA expression increased in explants incubated with E. coli, cytokines and LTs after 2 and 12h and aLTR inhibited the effect of LTs in explants incubated with E...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27836961/insights-from-imaging-the-implanting-embryo-and-the-uterine-environment-in-three-dimensions
#16
Ripla Arora, Adam Fries, Karina Oelerich, Kyle Marchuk, Khalida Sabeur, Linda C Giudice, Diana J Laird
Although much is known about the embryo during implantation, the architecture of the uterine environment in which the early embryo develops is not well understood. We employed confocal imaging in combination with 3D analysis to identify and quantify dynamic changes to the luminal structure of murine uterus in preparation for implantation. When applied to mouse mutants with known implantation defects, this method detected striking peri-implantation abnormalities in uterine morphology that cannot be visualized by histology...
December 15, 2016: Development
https://www.readbyqxmd.com/read/27830098/a-pregnancy-with-severe-hypertrophic-obstructive-cardiomyopathy-after-surgery-for-an-implantable-cardioverter-defibrillator-a-case-report-and-literature-review
#17
Takashi Mitsui, Hisashi Masuyama, Kentaro Ejiri, Kei Hayata, Hiroshi Ito, Yuji Hiramatsu
Hypertrophic obstructive cardiomyopathy (HOCM) is cardiac hypertrophy of ventricular myocardium with left ventricular outflow tract obstruction. We report a pregnancy with HOCM after defibrillator implantation surgery. The patient was a 33-year-old nulligravida and was categorized as New York Heart Association class II. Her brain natriuretic peptide (BNP) level was 724.6 pg/dL at preconception. She received careful pregnancy management. However, because frequent uterine contractions were observed at 25 weeks and 6 days of pregnancy, she was hospitalized, and magnesium sulfate was started as a tocolytic agent...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27707711/embryo-mortality-around-the-period-of-maintenance-of-the-corpus-luteum-causes-alterations-to-the-ovarian-function-of-lactating-dairy-cows
#18
Robert Wijma, Matias L Stangaferro, Manasi M Kamat, Sreelakshmi Vasudevan, Troy L Ott, Julio O Giordano
Objectives were to identify cows with embryo mortality (EM) around the period of corpus luteum (CL) maintenance by Interferon tau (IFNT) and characterize ovarian function in cows that underwent EM. Lactating Holstein cows received AI (Day = 0) with semen or extender only. From Day 14 to 42 transrectal ultrasonography was performed daily to monitor ovarian dynamics and uterine contents whereas blood was collected every 48 h to determine ISG15 and MX2 mRNA abundance in blood mononuclear cells (Day 14 to 22 only) and determination of hormone concentrations...
October 5, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27697519/mechanical-perspectives-on-the-anterior-posterior-axis-polarization-of-mouse-implanted-embryos
#19
Isao Matsuo, Ryuji Hiramatsu
In most mammals, embryonic development and growth proceed in the maternal uterus. Mouse late blastocyst embryos implant on the uterine epithelium around embryonic day (E)4.5, and immediately afterward the whole embryo's shape is dynamically changed from a bowl-like shape to an elongated egg-cylinder until E5.5. Concurrently, mouse anterior-posterior (A-P) axis polarization occurs by the emergence of distal visceral endoderm (DVE) cells at the cellular and molecular levels as the proximal-distal (P-D) axis. The embryonic growth and axis polarization are considered to be controlled primarily by multiple growth factors' signaling...
September 30, 2016: Mechanisms of Development
https://www.readbyqxmd.com/read/27686034/lipid-droplets-in-the-ovine-uterus-during-the-estrous-cycle-effects-of-nutrition-arginine-and-fsh
#20
Anna T Grazul-Bilska, Vilaivan Khanthusaeng, Casie S Bass, Samantha L Kaminski, Chainarong Navanukraw, Dale A Redmer
The aim of this study was to evaluate lipid droplet (LD) expression in uteri of FSH-treated or nontreated sheep administered with arginine (Arg) or vehicle (saline, Sal) and fed a control (C), excess (overfed, O) or restricted (underfed, U) diet. In experiment 1, ewes from each diet were randomly assigned to Arg or Sal treatments administered three times daily starting on Day 0 of the first estrous cycle until blood sample and uterine tissue collection at the early- or mid-luteal phase of the second estrous cycle or the late-luteal phase of the first estrous cycle...
January 1, 2017: Theriogenology
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