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https://www.readbyqxmd.com/read/27917295/circulating-human-papillomavirus-dna-detected-using-droplet-digital-pcr-in-the-serum-of-patients-diagnosed-with-early-stage-human-papillomavirus-associated-invasive-carcinoma
#1
Emmanuelle Jeannot, Véronique Becette, Maura Campitelli, Marie-Ange Calméjane, Emmanuelle Lappartient, Evelyne Ruff, Stéphanie Saada, Allyson Holmes, Dominique Bellet, Xavier Sastre-Garau
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours. Here we took advantage of the sensitive droplet digital PCR method to identify circulating human papillomavirus DNA in patients with human papillomavirus-associated carcinomas...
October 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27911818/planar-cell-polarity-signaling-in-the-uterus-directs-appropriate-positioning-of-the-crypt-for-embryo-implantation
#2
Jia Yuan, Jeeyeon Cha, Wenbo Deng, Amanda Bartos, Xiaofei Sun, Hsin-Yi Henry Ho, Jean-Paul Borg, Terry P Yamaguchi, Yingzi Yang, Sudhansu K Dey
Blastocyst implantation is a complex process requiring coordination of a dynamic sequence of embryo-uterine interactions. Blood vessels enter the uterus from the mesometrium, demarcating the uterus into mesometrial (M) and antimesometrial (AM) domains. Implantation occurs along the uterine longitudinal axis within specialized implantation chambers (crypts) that originate within the evaginations directed from the primary lumen toward the AM domain. The morphological orientation of crypts in rodent uteri was recognized more than a century ago, but the mechanism remained unknown...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27896299/basement-membrane-ultrastructure-and-component-localization-data-from-uterine-tissues-during-early-mouse-pregnancy
#3
Celestial R Jones-Paris, Sayan Paria, Taloa Berg, Juan Saus, Gautam Bhave, Bibhash C Paria, Billy G Hudson
Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua. Properties of BMs are maintained in homeostasis for most adult tissues. However, BM ultrastructure, composition, and localization are rapidly altered in select uterine tissues that are reprogrammed during pregnancy to enable early maternal-embryo interactions. Here, our data exhibit both static and dynamic BMs that were tracked in mouse uterine tissues during pre-, peri-, and postimplantation periods of pregnancy...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27871478/transendothelial-migration-of-human-umbilical-mesenchymal-stem-cells-across-uterine-endothelial-monolayers-junctional-dynamics-and-putative-mechanisms
#4
Neven A Ebrahim, Lopa Leach
INTRODUCTION: During pregnancy, fetal stem cells can transfer to the maternal circulation and participate in tissue repair. How they transmigrate across maternal endothelial barriers and whether they can subsequently influence maternal endothelial integrity is not known. METHODS: Mesenchymal stem cells (WJ-MSC) were isolated from Wharton's jelly and their interactions with human uterine microvascular endothelial cell (HUtMEC) monolayers, junctional occupancy and expression/phosphorylation of vascular endothelial (VE)- cadherin and vascular endothelial growth factor (VEGF-A) secretion was studied over 48h by real time, confocal microscopy, immunoblotting and ELISA...
December 2016: Placenta
https://www.readbyqxmd.com/read/27863551/in-vitro-cow-uterine-response-to-escherichia-coli-leukotrienes-and-cytokines
#5
A J Korzekwa, M Łupicka, B M- Socha, A A Szczepańska, E Piotrowicz, W Barański
The aim was to determine the dynamic profile of interactions between Escherichia coli (E. coli) and the actions of leukotrienes (LTs) and TNF and INFγ (cytokines) in the uterus in vitro. Uterine explants (N=6) were incubated for 2, 12 and 24h either as E. coli-treated (10(6)CFU) or non-treated and/or with: LTB4 and C4 (10(-6)M, for both LTs), LTs receptors antagonists (aLTR; 10(-6)M) and/or cytokines (each 10ng/ml). Toll Like Receptor 4 (TLR4) mRNA expression increased in explants incubated with E. coli, cytokines and LTs after 2 and 12h and aLTR inhibited the effect of LTs in explants incubated with E...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27836961/insights-from-imaging-the-implanting-embryo-and-the-uterine-environment-in-three-dimensions
#6
Ripla Arora, Adam Fries, Karina Oelerich, Kyle Marchuk, Khalida Sabeur, Linda C Giudice, Diana J Laird
Although much is known about the embryo during implantation, the architecture of the uterine environment in which the early embryo develops is not well understood. We employed confocal imaging in combination with 3D analysis to identify and quantify dynamic changes to the luminal structure of murine uterus in preparation for implantation. When applied to mouse mutants with known implantation defects, this method detected striking peri-implantation abnormalities in uterine morphology that cannot be visualized by histology...
November 11, 2016: Development
https://www.readbyqxmd.com/read/27830098/a-pregnancy-with-severe-hypertrophic-obstructive-cardiomyopathy-after-surgery-for-an-implantable-cardioverter-defibrillator-a-case-report-and-literature-review
#7
Takashi Mitsui, Hisashi Masuyama, Kentaro Ejiri, Kei Hayata, Hiroshi Ito, Yuji Hiramatsu
Hypertrophic obstructive cardiomyopathy (HOCM) is cardiac hypertrophy of ventricular myocardium with left ventricular outflow tract obstruction. We report a pregnancy with HOCM after defibrillator implantation surgery. The patient was a 33-year-old nulligravida and was categorized as New York Heart Association class II. Her brain natriuretic peptide (BNP) level was 724.6 pg/dL at preconception. She received careful pregnancy management. However, because frequent uterine contractions were observed at 25 weeks and 6 days of pregnancy, she was hospitalized, and magnesium sulfate was started as a tocolytic agent...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27707711/embryo-mortality-around-the-period-of-maintenance-of-the-corpus-luteum-causes-alterations-to-the-ovarian-function-of-lactating-dairy-cows
#8
Robert Wijma, Matias L Stangaferro, Manasi M Kamat, Sreelakshmi Vasudevan, Troy L Ott, Julio O Giordano
Objectives were to identify cows with embryo mortality (EM) around the period of corpus luteum (CL) maintenance by Interferon tau (IFNT) and characterize ovarian function in cows that underwent EM. Lactating Holstein cows received AI (Day = 0) with semen or extender only. From Day 14 to 42 transrectal ultrasonography was performed daily to monitor ovarian dynamics and uterine contents whereas blood was collected every 48 h to determine ISG15 and MX2 mRNA abundance in blood mononuclear cells (Day 14 to 22 only) and determination of hormone concentrations...
October 5, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27697519/mechanical-perspectives-on-the-anterior-posterior-axis-polarization-of-mouse-implanted-embryos
#9
Isao Matsuo, Ryuji Hiramatsu
In most mammals, embryonic development and growth proceed in the maternal uterus. Mouse late blastocyst embryos implant on the uterine epithelium around embryonic day (E)4.5, and immediately afterward the whole embryo's shape is dynamically changed from a bowl-like shape to an elongated egg-cylinder until E5.5. Concurrently, mouse anterior-posterior (A-P) axis polarization occurs by the emergence of distal visceral endoderm (DVE) cells at the cellular and molecular levels as the proximal-distal (P-D) axis. The embryonic growth and axis polarization are considered to be controlled primarily by multiple growth factors' signaling...
September 30, 2016: Mechanisms of Development
https://www.readbyqxmd.com/read/27686034/lipid-droplets-in-the-ovine-uterus-during-the-estrous-cycle-effects-of-nutrition-arginine-and-fsh
#10
Anna T Grazul-Bilska, Vilaivan Khanthusaeng, Casie S Bass, Samantha L Kaminski, Chainarong Navanukraw, Dale A Redmer
The aim of this study was to evaluate lipid droplet (LD) expression in uteri of FSH-treated or nontreated sheep administered with arginine (Arg) or vehicle (saline, Sal) and fed a control (C), excess (overfed, O) or restricted (underfed, U) diet. In experiment 1, ewes from each diet were randomly assigned to Arg or Sal treatments administered three times daily starting on Day 0 of the first estrous cycle until blood sample and uterine tissue collection at the early- or mid-luteal phase of the second estrous cycle or the late-luteal phase of the first estrous cycle...
September 2, 2016: Theriogenology
https://www.readbyqxmd.com/read/27679181/evaluation-of-vaginal-vault-position-with-dynamic-mri-in-women-who-had-laparoscopic-sacrocolpopexy-for-uterine-prolapse
#11
A T Yoldemir, C Cimsit, M Guclu, I N Akpinar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27623573/accurate-cervical-cell-segmentation-from-overlapping-clumps-in-pap-smear-images
#12
Youyi Song, Ee-Leng Tan, Xudong Jiang, Jie-Zhi Cheng, Dong Ni, Siping Chen, Baiying Lei, Tianfu Wang
Accurate segmentation of cervical cells in Pap smear images is an important step in automatic pre-cancer identification in the uterine cervix. One of the major segmentation challenges is overlapping of cytoplasm, which has not been well-addressed in previous studies. To tackle the overlapping issue, this paper proposes a learning-based method with robust shape priors to segment individual cell in Pap smear images to support automatic monitoring of changes in cells, which is a vital prerequisite of early detection of cervical cancer...
September 7, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27619726/embryo-implantation-triggers-dynamic-spatiotemporal-expression-of-the-basement-membrane-toolkit-during-uterine-reprogramming
#13
Celestial R Jones-Paris, Sayan Paria, Taloa Berg, Juan Saus, Gautam Bhave, Bibhash C Paria, Billy G Hudson
Basement membranes (BMs) are specialized extracellular scaffolds that influence behaviors of cells in epithelial, endothelial, muscle, nervous, and fat tissues. Throughout development and in response to injury or disease, BMs are fine-tuned with specific protein compositions, ultrastructure, and localization. These features are modulated through implements of the BM toolkit that is comprised of collagen IV, laminin, perlecan, and nidogen. Two additional proteins, peroxidasin and Goodpasture antigen-binding protein (GPBP), have recently emerged as potential members of the toolkit...
September 9, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27572151/domain-specific-partitioning-of-uterine-artery-endothelial-connexin43-and-caveolin-1
#14
Bryan C Ampey, Timothy J Morschauser, Jayanth Ramadoss, Ronald R Magness
Uterine vascular adaptations facilitate rises in uterine blood flow during pregnancy, which are associated with gap junction connexin (Cx) proteins and endothelial nitric oxide synthase. In uterine artery endothelial cells (UAECs), ATP activates endothelial nitric oxide synthase in a pregnancy (P)-specific manner that is dependent on Cx43 function. Caveolar subcellular domain partitioning plays key roles in ATP-induced endothelial nitric oxide synthase activation and nitric oxide production. Little is known regarding the partitioning of Cx proteins to caveolar domains or their dynamics with ATP treatment...
October 2016: Hypertension
https://www.readbyqxmd.com/read/27543267/a-dynamical-systems-model-of-progesterone-receptor-interactions-with-inflammation-in-human-parturition
#15
Douglas Brubaker, Alethea Barbaro, Mark R Chance, Sam Mesiano
BACKGROUND: Progesterone promotes uterine relaxation and is essential for the maintenance of pregnancy. Withdrawal of progesterone activity and increased inflammation within the uterine tissues are key triggers for parturition. Progesterone actions in myometrial cells are mediated by two progesterone receptor (PR) isoforms, PR-A and PR-B, that function as ligand-activated transcription factors. PR-B mediates relaxatory actions of progesterone, in part, by decreasing myometrial cell responsiveness to pro-inflammatory stimuli...
2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27533929/dynamic-monitoring-of-menopause-hormone-therapy-and-defining-the-cut-off-value-of-endometrial-thickness-during-uterine-bleeding
#16
Qiu Sheng, Jun Yang, Qiaoling Zhao, Fen Li
The aim of this study was to evaluate the effects of low-dose tibolone therapy on ovarian area, uterine volume and endometrial thickness, and define the cut-off value of endometrial thickness for curettage during uterine bleeding. We followed 619 postmenopausal women, aged 40-60 years, for two years. There were 301 subjects in the low-dose tibolone treatment group and 318 subjects in the control group. The ovarian area, uterine volume and endometrial thickness in all participants were measured by transvaginal ultrasound prior to, one and two years post enrollment, respectively...
May 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27525332/the-effect-of-steroid-hormones-on-the-mrna-expression-of-oct4-and-sox2-in-uterine-tissue-of-the-ovariectomized-mice-model-of-menopause
#17
Marzieh Davoudi, Saeed Zavareh, Mohammad Taghi Ghorbanian, Seyed Hassan Paylakhi, Seyed Reza Mohebbi
BACKGROUND: The uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. As such, uterine stem cells have been studied in recent years. Transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. OBJECTIVE: The present research evaluated the mRNA expression of oct4 and sox2 in the uterine tissues of ovariectomized mice treated with steroid hormones. MATERIALS AND METHODS: In this experimental study, adult virgin female mice were ovariectomized and treated with estradiol 17β (E2), progesterone (P4), and a combination of E2 and P4 (E2 & P4) for 5 days...
July 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27501905/modified-mr-defecography-without-rectal-filling-in-obstructed-defecation-syndrome-initial-experience
#18
Hebatallah Hassan Mamdouh Hassan, Abdelaziz Mohamed Elnekiedy, Walid Galal Elshazly, Nagy N N Naguib
OBJECTIVE: To evaluate the role of dynamic MR defecography before rectal filling in detecting occult anterior compartment prolapse in patients with obstructed defecation. METHODS: This prospective study was approved by the ethics committee. Seventy six females with obstructed defecation underwent dynamic MR defecography before and after rectal filling. Pre-rectal and post-rectal filling sequences were interpreted separately by two radiologists on two different settings with a time interval of one week...
September 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27459248/application-of-flash-3d-dynamic-contrast-enhanced-imaging-for-diagnosis-of-endometrial-carcinoma
#19
Lixin Du, Xiaohu Li, Xixiong Qiu, Xiaolei Liu, Yuli Wang, Yongqiang Yu
OBJECTIVE: To investigate the application and value of fast low-angle shot three-dimensional (FLASH-3D) dynamic contrast-enhanced MRI for the pre-operative staging of endometrial carcinoma. METHODS: This prospective study enrolled 48 patients with complete clinical data and pathologically confirmed endometrial carcinoma from July 2012 to March 2014. After routine MRI examination, subjects underwent FLASH-3D dynamic contrast-enhanced examination. The dynamically enhanced features of the uterine wall and tumours were analyzed...
October 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27448058/fertile-ground-human-endometrial-programming-and-lessons-in-health-and-disease
#20
Jemma Evans, Lois A Salamonsen, Amy Winship, Ellen Menkhorst, Guiying Nie, Caroline E Gargett, Eva Dimitriadis
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired, regenerated and remodelled, primarily under the orchestration of oestrogen and progesterone, in preparation for embryo implantation. Humans are among the very few species that menstruate and that, consequently, are equipped with unique cellular and molecular mechanisms controlling these cyclic processes. Many reproductive pathologies are specific to menstruating species, and studies in animal models rarely translate to humans...
November 2016: Nature Reviews. Endocrinology
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