Read by QxMD icon Read

Dynamic uterine

Robert Wijma, Matias L Stangaferro, Manasi M Kamat, Sreelakshmi Vasudevan, Troy L Ott, Julio O Giordano
Objectives were to identify cows with embryo mortality (EM) around the period of corpus luteum (CL) maintenance by Interferon tau (IFNT) and characterize ovarian function in cows that underwent EM. Lactating Holstein cows received AI (Day = 0) with semen or extender only. From Day 14 to 42 transrectal ultrasonography was performed daily to monitor ovarian dynamics and uterine contents whereas blood was collected every 48 h to determine ISG15 and MX2 mRNA abundance in blood mononuclear cells (Day 14 to 22 only) and determination of hormone concentrations...
October 5, 2016: Biology of Reproduction
Isao Matsuo, Ryuji Hiramatsu
In most mammals, embryonic development and growth proceed in the maternal uterus. Mouse late blastocyst embryos implant on the uterine epithelium around embryonic day (E)4.5, and immediately afterward the whole embryo's shape is dynamically changed from a bowl-like shape to an elongated egg-cylinder until E5.5. Concurrently, mouse anterior-posterior (A-P) axis polarization occurs by the emergence of distal visceral endoderm (DVE) cells at the cellular and molecular levels as the proximal-distal (P-D) axis. The embryonic growth and axis polarization are considered to be controlled primarily by multiple growth factors' signaling...
September 30, 2016: Mechanisms of Development
Anna T Grazul-Bilska, Vilaivan Khanthusaeng, Casie S Bass, Samantha L Kaminski, Chainarong Navanukraw, Dale A Redmer
The aim of this study was to evaluate lipid droplet (LD) expression in uteri of FSH-treated or nontreated sheep administered with arginine (Arg) or vehicle (saline, Sal) and fed a control (C), excess (overfed, O) or restricted (underfed, U) diet. In experiment 1, ewes from each diet were randomly assigned to Arg or Sal treatments administered three times daily starting on Day 0 of the first estrous cycle until blood sample and uterine tissue collection at the early- or mid-luteal phase of the second estrous cycle or the late-luteal phase of the first estrous cycle...
September 2, 2016: Theriogenology
A T Yoldemir, C Cimsit, M Guclu, I N Akpinar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Youyi Song, Ee-Leng Tan, Xudong Jiang, Jie-Zhi Cheng, Dong Ni, Siping Chen, Baiying Lei, Tianfu Wang
Accurate segmentation of cervical cells in Pap smear images is an important step in automatic pre-cancer identification in the uterine cervix. One of the major segmentation challenges is overlapping of cytoplasm, which has not been well-addressed in previous studies. To tackle the overlapping issue, this paper proposes a learning-based method with robust shape priors to segment individual cell in Pap smear images to support automatic monitoring of changes in cells, which is a vital prerequisite of early detection of cervical cancer...
September 7, 2016: IEEE Transactions on Medical Imaging
Celestial R Jones-Paris, Sayan Paria, Taloa Berg, Juan Saus, Gautam Bhave, Bibhash C Paria, Billy G Hudson
Basement membranes (BMs) are specialized extracellular scaffolds that influence behaviors of cells in epithelial, endothelial, muscle, nervous, and fat tissues. Throughout development and in response to injury or disease, BMs are fine-tuned with specific protein compositions, ultrastructure, and localization. These features are modulated through implements of the BM toolkit that is comprised of collagen IV, laminin, perlecan, and nidogen. Two additional proteins, peroxidasin and Goodpasture antigen-binding protein (GPBP), have recently emerged as potential members of the toolkit...
September 9, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
Bryan C Ampey, Timothy J Morschauser, Jayanth Ramadoss, Ronald R Magness
Uterine vascular adaptations facilitate rises in uterine blood flow during pregnancy, which are associated with gap junction connexin (Cx) proteins and endothelial nitric oxide synthase. In uterine artery endothelial cells (UAECs), ATP activates endothelial nitric oxide synthase in a pregnancy (P)-specific manner that is dependent on Cx43 function. Caveolar subcellular domain partitioning plays key roles in ATP-induced endothelial nitric oxide synthase activation and nitric oxide production. Little is known regarding the partitioning of Cx proteins to caveolar domains or their dynamics with ATP treatment...
October 2016: Hypertension
Douglas Brubaker, Alethea Barbaro, Mark R Chance, Sam Mesiano
BACKGROUND: Progesterone promotes uterine relaxation and is essential for the maintenance of pregnancy. Withdrawal of progesterone activity and increased inflammation within the uterine tissues are key triggers for parturition. Progesterone actions in myometrial cells are mediated by two progesterone receptor (PR) isoforms, PR-A and PR-B, that function as ligand-activated transcription factors. PR-B mediates relaxatory actions of progesterone, in part, by decreasing myometrial cell responsiveness to pro-inflammatory stimuli...
2016: BMC Systems Biology
Qiu Sheng, Jun Yang, Qiaoling Zhao, Fen Li
The aim of this study was to evaluate the effects of low-dose tibolone therapy on ovarian area, uterine volume and endometrial thickness, and define the cut-off value of endometrial thickness for curettage during uterine bleeding. We followed 619 postmenopausal women, aged 40-60 years, for two years. There were 301 subjects in the low-dose tibolone treatment group and 318 subjects in the control group. The ovarian area, uterine volume and endometrial thickness in all participants were measured by transvaginal ultrasound prior to, one and two years post enrollment, respectively...
May 2016: Journal of Biomedical Research
Marzieh Davoudi, Saeed Zavareh, Mohammad Taghi Ghorbanian, Seyed Hassan Paylakhi, Seyed Reza Mohebbi
BACKGROUND: The uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. As such, uterine stem cells have been studied in recent years. Transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. OBJECTIVE: The present research evaluated the mRNA expression of oct4 and sox2 in the uterine tissues of ovariectomized mice treated with steroid hormones. MATERIALS AND METHODS: In this experimental study, adult virgin female mice were ovariectomized and treated with estradiol 17β (E2), progesterone (P4), and a combination of E2 and P4 (E2 & P4) for 5 days...
July 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
Hebatallah Hassan Mamdouh Hassan, Abdelaziz Mohamed Elnekiedy, Walid Galal Elshazly, Nagy N N Naguib
OBJECTIVE: To evaluate the role of dynamic MR defecography before rectal filling in detecting occult anterior compartment prolapse in patients with obstructed defecation. METHODS: This prospective study was approved by the ethics committee. Seventy six females with obstructed defecation underwent dynamic MR defecography before and after rectal filling. Pre-rectal and post-rectal filling sequences were interpreted separately by two radiologists on two different settings with a time interval of one week...
September 2016: European Journal of Radiology
Lixin Du, Xiaohu Li, Xixiong Qiu, Xiaolei Liu, Yuli Wang, Yongqiang Yu
OBJECTIVE: To investigate the application and value of fast low-angle shot three-dimensional (FLASH-3D) dynamic contrast-enhanced MRI for the pre-operative staging of endometrial carcinoma. METHODS: This prospective study enrolled 48 patients with complete clinical data and pathologically confirmed endometrial carcinoma from July 2012 to March 2014. After routine MRI examination, subjects underwent FLASH-3D dynamic contrast-enhanced examination. The dynamically enhanced features of the uterine wall and tumours were analyzed...
October 2016: British Journal of Radiology
Jemma Evans, Lois A Salamonsen, Amy Winship, Ellen Menkhorst, Guiying Nie, Caroline E Gargett, Eva Dimitriadis
The human endometrium is a highly dynamic tissue that is cyclically shed, repaired, regenerated and remodelled, primarily under the orchestration of oestrogen and progesterone, in preparation for embryo implantation. Humans are among the very few species that menstruate and that, consequently, are equipped with unique cellular and molecular mechanisms controlling these cyclic processes. Many reproductive pathologies are specific to menstruating species, and studies in animal models rarely translate to humans...
November 2016: Nature Reviews. Endocrinology
Candelaria Gonzalez Moreno, Cecilia Fontana, Pier Sandro Cocconcelli, María Luisa Callegari, María Claudia Otero
AIM: To evaluate changes in the resident microbial population in the cranial vaginal mucosa induced by a a progesterone-releasing intravaginal device (PRID) compared to the vaginal microbiota of cows with reproductive disorders. METHODS AND RESULTS: Vaginal discharge was evaluated by clinical examination and a Vaginitis Diagnosis Score was performed by exfoliative cytology. All samples classified as positive and some classified as negative by clinical evaluation were later diagnosed as positive for vaginitis by cytological analysis...
July 21, 2016: Journal of Applied Microbiology
Sayaka Daido, Aki Kido, Masako Kataoka, Asako Nakai, Koji Fujimoto, Hiroshi Kusahara, Tomohisa Okada, Kaori Togashi
PURPOSE: To investigate the influence of lactation and ovarian hormones on uterine morphology and function by comparing uteruses of lactating women with nulliparous women on MRI. MATERIALS AND METHODS: Sagittal T2WI and cine MR images were obtained with 1.5 Tesla (T) and 3T scanner from 22 lactating women and 16 nulliparous women as a control group. The lactating group was further divided into amenorrhea and menorrhea subgroups. Uterine area, endometrial thickness, junctional zone (JZ) thickness, relative signal intensity (rSI) of the JZ, and of the outer myometrium (OM), were measured on T2-weighted fast spin echo images as static image parameters...
July 15, 2016: Journal of Magnetic Resonance Imaging: JMRI
Daniel Dominguez, Yi-Hsuan Tsai, Nicholas Gomez, Deepak Kumar Jha, Ian Davis, Zefeng Wang
Progression through the cell cycle is largely dependent on waves of periodic gene expression, and the regulatory networks for these transcriptome dynamics have emerged as critical points of vulnerability in various aspects of tumor biology. Through RNA-sequencing of human cells during two continuous cell cycles (>2.3 billion paired reads), we identified over 1 000 mRNAs, non-coding RNAs and pseudogenes with periodic expression. Periodic transcripts are enriched in functions related to DNA metabolism, mitosis, and DNA damage response, indicating these genes likely represent putative cell cycle regulators...
August 2016: Cell Research
Z Roth, D Wolfenson
Reduced reproductive performance of lactating cows is strongly associated with environmental and pathogenic stressors. This review summarizes the most recent knowledge on the effects of acute or chronic heat stress (HS) and acute or chronic intramammary infection (IMI) on ovarian function. It also offers various approaches for improving the fertility of cows under chronic HS or IMI. Comparing the 2 stressors reveals a few similarities in the mode of alteration in the hypothalamus-pituitary-ovarian axis, in particular, in the follicle and its enclosed oocyte...
July 2016: Domestic Animal Endocrinology
Eduardo S Ribeiro, José E P Santos, William W Thatcher
Elongation of the preimplantation conceptus is a prerequisite for successful pregnancy in ruminants and depends on histotroph secretion by the endometrium. Lipids are an essential component of the histotroph, and recent studies indicate that lipids have important roles in the elongation phase of conceptus development. The onset of elongation is marked by dynamic changes in the transcriptome of trophectoderm cells, which are associated with lipid metabolism. During elongation, the trophectoderm increases transcript expression of genes related to uptake, metabolism and de novo biosynthesis of fatty acids and prostaglandins...
October 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Kazuya Kusama, Rulan Bai, Atsushi Ideta, Yoshito Aoyagi, Kiyoshi Okuda, Kazuhiko Imakawa
Dynamic changes in bovine conceptus and endometrium occur during early gestation, in which the conceptus undergoes epithelial to mesenchymal transition (EMT) after the conceptus attachment to endometrium. To characterize EMT inducing factors, we initially undertook iTRAQ analysis with bovine uterine flushing (UF) obtained from pregnant animals on days 17 (P17: pre-attachment) and 20 (P20: post-attachment). The iTRAQ analysis demonstrated that follistatin (FST), an inhibitor of activin A, increased in P20 UF...
October 15, 2016: Molecular and Cellular Endocrinology
Youngsok Choi, Hye-Ryun Kim, Eun Jin Lim, Miseon Park, Jung Ah Yoon, Yeon Sun Kim, Eun-Kyung Kim, Ji-Eun Shin, Ji Hyang Kim, Hwang Kwon, Haengseok Song, Dong-Hee Choi
Intimate two-way interactions between the implantation-competent blastocyst and receptive uterus are prerequisite for successful embryo implantation. In humans, recurrent/repeated implantation failure (RIF) may occur due to altered uterine receptivity with aberrant gene expression in the endometrium as well as genetic defects in embryos. Several studies have been performed to understand dynamic changes of uterine transcriptome during menstrual cycles in humans. However, uterine transcriptome of the patients with RIF has not been clearly investigated yet...
2016: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"