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https://www.readbyqxmd.com/read/28653669/dnk-cells-facilitate-the-interaction-between-trophoblastic-and-endothelial-cells-via-vegf-c-and-hgf
#1
Liyang Ma, Guanlin Li, Guangming Cao, Yuchun Zhu, Mei-Rong Du, Yangyu Zhao, Hao Wang, Yanlei Liu, Yanyan Yang, Yu-Xia Li, Da-Jin Li, Huixia Yang, Yan-Ling Wang
Decidual NK (dNK) cells, identified as CD56(bright)CD16(-)CD3(-), account for ~70% of lymphocytes within the uterine wall during early pregnancy. Accumulating evidence suggests that tight interactions between placental trophoblasts and dNK cells are critical for trophoblast cell differentiation. However, the underlying mechanism remains to be explored in detail. In the present study, conditioned medium (CM) was collected from cultured primary human dNK cells. Primary cytotrophoblasts (CTBs) or the human trophoblast cell line HTR8/SVneo was treated with dNK-CM and co-cultured with human umbilical vein endothelial cells (HUVECs) in a three-dimensional Matrigel scaffold, and the formation of tube structures was dynamically monitored with live cell imaging...
June 9, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28633489/effects-of-early-pregnancy-on-uterine-lymphocytes-and-endometrial-expression-of-immune-regulatory-molecules-in-dairy-heifers1
#2
Sreelakshmi Vasudevan, Manasi M Kamat, Sadhat S Walusimbi, Joy L Pate, Troy L Ott
Natural killer (NK) cells are essential for establishment of human and rodent pregnancies. The function of these and other cytotoxic T cells (CTL) is controlled by stimulatory and inhibitory signaling. A role for cytotoxic cells during early pregnancy in cattle has not been described, but regulation of their function at the fetal-maternal interface is thought to be critical for conceptus survival. The hypothesis that the relative abundance of CTL and expression of inhibitory signaling molecules is increased by the conceptus during early pregnancy was tested...
June 19, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28594645/novel-imaging-techniques-in-gynaecological-cancer
#3
Vincent Vandecaveye, Raphaëla Dresen, Frederik De Keyzer
PURPOSE OF REVIEW: To describe the added value of novel functional MRI techniques towards detection, staging, characterization, response monitoring and prognostication in gynaecological cancer. RECENT FINDINGS: Functional MRI including diffusion-weighted imaging (DWI)-MRI and dynamic contrast-enhanced (DCE)-MRI adds structural, hemodynamic and physiological information to anatomical MRI. In endometrial and cervical cancer, the addition of DWI-MRI and DCE-MRI improves tumour detection as well as staging of uterine and extra-uterine pelvic spread...
June 7, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28592665/signs-of-embryo-maternal-communication-mirnas-in-the-maternal-serum-of-pregnant-pigs
#4
Zaneta Paulina Reliszko, Zdzislaw Gajewski, Monika Marzena Kaczmarek
Circulating miRNAs were proposed to be indicators of normal or complicated pregnancies. Based on this knowledge and our recent transcriptomic approach showing expression of miRNAs in the porcine endometrium, conceptuses and uterine extracellular vesicles during pregnancy, we have hypothesized that signs of ongoing local embryo-maternal crosstalk involving miRNAs can be detected in the circulation of pregnant gilts as early as a few days after maternal recognition of pregnancy. By applying several molecular biology techniques that differ in dynamic range and precision in maternal serum of Day 16 pregnant pigs, we were able to show for the first time increased levels of several miRNAs, previously reported to be expressed in either conceptuses and extracellular vesicles (miR-26a and miR-125b) or pregnant endometrium (miR-23b)...
June 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28583600/administration-of-2-5%C3%A2-mg-of-estradiol-followed-by-1-500%C3%A2-mg-of-progesterone-to-anovulatory-mares-promote-similar-uterine-morphology-hormone-concentrations-and-molecular-dynamics-to-those-observed-in-cyclic-mares
#5
E S M Silva, F S Ignácio, S C Fritsch, D S Zanoni, J C F Pantoja, J P Oliveira-Filho, C Meira
To test the hypothesis that the administration of 2.5 mg of estradiol benzoate (EB) followed by 1500 mg of long acting progesterone (LA P4) causes similar uterine changes and molecular dynamics in anovulatory mares to those observed in cyclic ones, we evaluated the changes of estrogen (ERα and ERβ) and progesterone receptors (PR) in anestrous, transitional and cyclic mares by RT-qPCR and immunohistochemistry. In addition, we evaluated uterine edema, tonus and estrogens and progesterone plasma profile. Endometrial biopsies were taken from anestrous and transitional mares immediately before EB injection, 48 h after EB administration and five days after LA P4 was given...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28578177/the-impact-of-uterine-immaturity-on-obstetrical-syndromes-during%C3%A2-adolescence
#6
Ivo Brosens, Joanne Muter, Caroline Gargett, Patrick Puttemans, Giuseppe Benagiano, Jan J Brosens
Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28566515/a-microfluidics-assay-to-study-invasion-of-human-placental-trophoblast-cells
#7
Yassen Abbas, Carolin Melati Oefner, William J Polacheck, Lucy Gardner, Lydia Farrell, Andrew Sharkey, Roger Kamm, Ashley Moffett, Michelle L Oyen
Pre-eclampsia, fetal growth restriction and stillbirth are major pregnancy disorders throughout the world. The underlying pathogenesis of these diseases is defective placentation characterized by inadequate invasion of extravillous placental trophoblast cells into the uterine arteries. How trophoblast invasion is controlled remains an unanswered question but is influenced by maternal uterine immune cells called decidual natural killer cells. Here, we describe an in vitro microfluidic invasion assay to study the migration of primary human trophoblast cells...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28557403/-improved-management-of-patients-in-the-detection-of-fluid-in-the-uterine-cavity-during-ultrasound-examination-of-small-pelvis-in-postmenopausal-women
#8
M S Selihova, S V Vdovin, M V Michaylovskya
In carrying out preventive ultrasound in postmenopausal often reveals the presence of fluid in the uterine cavity and exhibiting as serozometra, whereby the patient is sent to the gynecological hospital to perform hysteroscopy. The analysis of 55 case histories of patients with serozometra treated in gynecological departments of Volgograd 2013-2015 years. The findings suggest that serozometra the majority (82,4 %) of the cases is not accompanied by endometrial pathology , thus intrauterine intervention was performed unfounded...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28548328/epithelioid-trophoblastic-tumor-of-the-uterus-a-case-report-with-radiologic-pathologic-correlation
#9
Ayumi Ohya, Kayoko Higuchi, Hisashi Shimojo, Yasunari Fujinaga, Masumi Kadoya, Shigeki Shiohara
Herein, we report a rare case of an epithelioid trophoblastic tumor of the uterus with radiologic-pathologic correlation in a 56-year-old postmenopausal woman. On T2-weighted magnetic resonance (MR) imaging, the tumor appeared as a hypointense irregular mass compared with the surrounding myometrium of the uterine corpus and encircled the cavity of the lower uterine segment. On dynamic contrast-enhanced MR images, the tumor appeared as a hypovascular mass and an inhomogeneously hyperintense mass in the delayed phase...
May 26, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28531272/a-novel-isoform-of-tet1-that-lacks-a-cxxc-domain-is-overexpressed-in-cancer
#10
Charly R Good, Jozef Madzo, Bela Patel, Shinji Maegawa, Nora Engel, Jaroslav Jelinek, Jean-Pierre J Issa
TET1 oxidizes methylated cytosine into 5-hydroxymethylcytosine (5hmC), resulting in regulation of DNA methylation and gene expression. Full length TET1 (TET1FL) has a CXXC domain that binds to unmethylated CpG islands (CGIs). This CXXC domain allows TET1 to protect CGIs from aberrant methylation, but it also limits its ability to regulate genes outside of CGIs. Here, we report a novel isoform of TET1 (TET1ALT) that has a unique transcription start site from an alternate promoter in intron 2, yielding a protein with a unique translation start site...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28494174/human-endometrial-stromal-cell-plasticity-reversible-sflt1-expression-negatively-coincides-with-decidualization
#11
Hanh N Cottrell, JuanJuan Wu, Bassam H Rimawi, Juan Manuel Duran, Jessica B Spencer, Neil Sidell, Augustine Rajakumar
Preeclampsia (PE) is a major complication of pregnancy in which the placenta is known to have shallow implantation into the uterine decidua. Studies have implicated soluble fms-like tyrosine kinase-1 (sFlt1), a soluble vascular endothelial growth factor (VEGF) receptor protein, in the pathogenesis of PE. sFlt1 has the ability to bind to and neutralize the angiogenic functions of VEGF and placental growth factor (PlGF). The presence of sFlt1 and its action in the endometrium is yet to be determined. We hypothesize that endometrial stromal cells (ESC) at the maternal-fetal interface may play a role in sFlt-1 regulation during pregnancy...
May 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28487952/expression-of-reproductive-hormone-receptors-and-contraction%C3%A2-associated-genes-in-porcine-uterus-during-the-estrous-cycle
#12
Sung-Min An, Sun Suk Kim, Jun Kim, Mee-Na Park, Jae-Eon Lee, Seong Keun Cho, Kyu-Sup Lee, Beum-Soo An
Contraction of uterus tissue frequently occurs throughout the estrous cycle and is regulated by several endogenous factors, including estradiol, progesterone, luteinizing hormone, follicle‑stimulating hormone, oxytocin (OXT) and contraction‑associated proteins (CAPs). Contraction activity of uterus tissue according to the estrous cycle is important, due to the fact that it is directly associated with balanced implantation and stable pregnancy. However, few studies have examined the mechanism of uterus contraction activity in a porcine model...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28461768/cervical-elastography-during-pregnancy-clinical-perspectives
#13
REVIEW
Malgorzata Swiatkowska-Freund, Krzysztof Preis
Uterine cervix is a part of the uterus responsible for maintaining pregnancy till term. As long as the cervix remains long and firm and its internal orifice (os) is closed, it can withstand enlargement of the uterine contents and resultant growing pressure. Mechanical properties of the cervix change during pregnancy; the cervix ripens prior to delivery, then effaces and dilates with contractions of the uterus. Ripening of the cervix can be assessed using the Bishop score and ultrasonographically determined length of the cervical canal and internal os...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28428364/role-of-oestrogen-receptor-signaling-in-skeletal-response-to-leptin-in-female-ob-ob-mice
#14
Russell T Turner, Kenneth A Philbrick, Amida Kuah, Adam J Branscum, Urszula T Iwaniec
Leptin, critical in regulation of energy metabolism, is also important for normal bone growth, maturation and turnover. Compared to wild type (WT) mice, bone mass is lower in leptin-deficient ob/ob mice; osteopenia in growing ob/ob mice is due to decreased bone accrual, and is associated with reduced longitudinal bone growth, impaired cancellous bone maturation and increased marrow adipose tissue (MAT). However, leptin deficiency also results in gonadal dysfunction, disrupting production of gonadal hormones which regulate bone growth and turnover...
April 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28427122/-application-on-the-quantitative-perfusion-parameters-of-dynamic-contrast-enhanced-mri-in-the-pathological-subtype-of-uterine-leiomyoma
#15
J Zheng, Z H Zhao, J F Yang, L Zhao, L M Yang, H J Hu
Objective: To analyze the value of the quantitative perfusion parameters of dynamic contrast-enhanced MRI(DCE-MRI) in the pathological subtype of uterine leiomyoma. Methods: A total of 35 cases of uterine leiomyoma confirmed by surgery and pathology were retrospectively analyzed in Shaoxing People's Hospital from October 2015 to May 2016.All cases underwent DCE-MRI. Quantitative perfusion parameters were prospectively measured and analyzed, including transfer constant (K(trans)) , efflux rate constant (K(ep)), extravascular extracellular space volume ratio (V(e)), blood plasma volume ratio (V(p)), permeability surface area product (PS) and plasma flow (F(p)) , using signal-input two-compartment tracer kinetic models (Extended Tofts model and Exchange model) in 35 leiomyoma cases...
April 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28417191/mapping-of-estradiol-binding-sites-through-receptor-micro-autoradiography-in-the-endometrial-stroma-of-early-pregnant-mice
#16
Telma M T Zorn, Rodolfo R Favaro, Mauricio Soto-Suazo, Walter E Stumpf
Estradiol triggers key biological responses in the endometrium, which rely on the presence and levels of its cognate receptors on target cells. Employing the receptor micro-autoradiography (RMAR) technique, we aimed to provide a temporal and spatial map of the functional binding sites for estradiol in the mouse endometrial stroma during early pregnancy. Uterine samples from days 1.5 to 7.5 of pregnancy were collected 1 h after tritiated- (3H-) estradiol administration and prepared for RMAR analysis. Autoradiographic incorporation of 3H-thymidine (after 1-h pulse) was evaluated over the same gestational interval...
April 17, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28413155/effects-of-natural-environment-on-reproductive-histo-morphometric-dynamics-of-female-dromedary-camel
#17
Hafiz Muhammad Ali, Anas Sarwar Qureshi, Riaz Hussain, Giorgia Urbinati, Mohammad Zahid Mustafa, Farah Ali, Abdul Manan, Liliane Massaad-Massade
Camel shows a seasonal breeding pattern with enhanced reproductive activity during the period of low climatic temperature, high rainfall and better food conditions. Therefore, the study was conducted to explore the underlying seasonal effects on histological dimensions of reproductive tract in adult female one-humped camel (Camelus dromedarius) kept in the natural environment of Pakistan. A total 25 reproductive tracts were collected during spring, summer, autumn and winter seasons and were analysed for histo-morphometric parameters during different environmental conditions...
March 29, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28394884/long-term-hormone-responsive-organoid-cultures-of-human-endometrium-in-a-chemically-defined-medium
#18
Margherita Y Turco, Lucy Gardner, Jasmine Hughes, Tereza Cindrova-Davies, Maria J Gomez, Lydia Farrell, Michael Hollinshead, Steven G E Marsh, Jan J Brosens, Hilary O Critchley, Benjamin D Simons, Myriam Hemberger, Bon-Kyoung Koo, Ashley Moffett, Graham J Burton
In humans, the endometrium, the uterine mucosal lining, undergoes dynamic changes throughout the menstrual cycle and pregnancy. Despite the importance of the endometrium as the site of implantation and nutritional support for the conceptus, there are no long-term culture systems that recapitulate endometrial function in vitro. We adapted conditions used to establish human adult stem-cell-derived organoid cultures to generate three-dimensional cultures of normal and decidualized human endometrium. These organoids expand long-term, are genetically stable and differentiate following treatment with reproductive hormones...
May 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28386692/the-usefulness-of-mr-defecography-in-the-evaluation-of-pelvic-floor-dysfunction-our-experience-using-3t-mri
#19
Mahasen S Al-Najar, Ahmed F Ghanem, Saif Aldeen S AlRyalat, Nosaiba T Al-Ryalat, Sultan O Alhajahjeh
PURPOSE: To assess the usefulness of MR defecography in evaluating pelvic floor dysfunction, and to correlate several pelvic organ abnormalities with each other and with patients' symptoms and characteristics. METHODS: MR defecographic examinations performed in 3T MRI machine of 95 patients (70 females, 25 males; mean age 48) were retrospectively reviewed. Pelvic organ abnormalities from all three compartments were recorded, including the anorectal junction descent, anterior rectocele, and cystocele...
April 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28373404/precancer-atlas-to-drive-precision-prevention-trials
#20
Avrum Spira, Matthew B Yurgelun, Ludmil Alexandrov, Anjana Rao, Rafael Bejar, Kornelia Polyak, Marios Giannakis, Ali Shilatifard, Olivera J Finn, Madhav Dhodapkar, Neil E Kay, Esteban Braggio, Eduardo Vilar, Sarah A Mazzilli, Timothy R Rebbeck, Judy E Garber, Victor E Velculescu, Mary L Disis, Douglas C Wallace, Scott M Lippman
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process. The biology of neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, including: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal of benefit from imaging-based early detection research in high-germline risk for pancreatic neoplasia, elucidating early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention trial, and insights into the intricate germline-somatic-immunity interaction landscape...
April 1, 2017: Cancer Research
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