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https://www.readbyqxmd.com/read/28535549/epidural-dexamethasone-influences-postoperative-analgesia-after-major-abdominal-surgery
#1
Jeong-Min Hong, Kyung-Hoon Kim, Hyeon Jeong Lee, Jae-Young Kwon, Hae-Kyu Kim, Hyae-Jin Kim, Ah-Reum Cho, Wang-Seok Do, Hyo Sung Kim
BACKGROUND: Epidurally administered dexamethasone might reduce postoperative pain. However, the effect of epidural administration of dexamethasone on postoperative epidural analgesia in major abdominal surgery has been doubtful. OBJECTIVES: To investigate the effects and optimal dose of epidural dexamethasone on pain after major abdominal surgery. STUDY DESIGN: A prospective randomized, double-blind study. SETTING: University hospital...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535449/the-center-for-epidemiological-studies-depression-scale-ces-d-measurement-equivalence-across-gender-groups-in-hispanic-college-students
#2
Consuelo Arbona, Andrea Burridge, Norma Olvera
BACKGROUND: This study examined among Hispanic college students the factor structure and gender measurement invariance of the Center for Epidemiologic Studies Depression (CES-D) scale. The CES-D's original 20 item four-factor model was compared to a recently proposed 14 item, three-factor model. METHODS: Participants included 858 Hispanic undergraduates at an ethnically diverse, major research, urban, public university in the Southwest United States (U.S.). Multigroup confirmatory factor analyses (CFAs) and structural equation modeling were used to examine the factor structure, gender invariance, and construct validity of the CES-D scores...
May 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28535408/differences-in-clinical-and-cognitive-variables-in-seasonal-affective-disorder-compared-to-depressive-related-disorders-evidence-from-a-population-based-study-in-finland
#3
I Morales-Muñoz, S Koskinen, T Partonen
BACKGROUND: Seasonal affective disorder (SAD) is a type of depression with seasonal pattern. Although it involves some idiosyncratic symptoms, it can overlap with other depressive disorders such as major depressive disorder (MDD) or dysthymia. We aimed to characterize the differences in specific cognitive and clinical symptoms between SAD and depressive-related disorders. METHODS: In total, 4554 Finnish subjects from the population-based Health 2011 Survey were interviewed with the Munich version of Composite International Diagnostic Interview (M-CIDI) and filled in the Seasonal Pattern Assessment Questionnaire (SPAQ)...
March 28, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28535406/anhedonia-predicts-poor-psychosocial-functioning-results-from-a-large-cohort-of-patients-treated-for-major-depressive-disorder-by-general-practitioners
#4
F Vinckier, D Gourion, S Mouchabac
BACKGROUND: Anhedonia is a core symptom of major depression and a key prognostic factor that is often poorly explored in clinical trials of major depressive disorder (MDD). Beyond symptomatic remission, psychosocial functioning also reveals difficulty in achieving remission in patients with MDD. The main objective of this study was to explore the interrelationships between social functioning and anhedonia on a longitudinal basis. METHODS: In total, 1570 outpatients treated for MDD with agomelatine were included...
March 8, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28535397/quality-of-life-anxiety-and-depression-in-patients-with-hiv-aids-who-present-poor-adherence-to-antiretroviral-therapy-a-cross-sectional-study-in-salvador-brazil
#5
Mónica Narváez Betancur, Liliane Lins, Irismar Reis de Oliveira, Carlos Brites
The introduction of highly active antiretroviral therapy marked a major gain in efficacy of HIV/AIDS treatment and a reduction in morbidity and mortality of the infected patients. However, high levels of adherence are required to obtain virologic suppression. In Brazil, the policy of free and universal access to antiretroviral therapy has been in place since 1996, although there are reports of poor adherence. OBJECTIVE: To define the clinical, demographic and psychological characteristics, and quality of life of patients with HIV/AIDS who present poor adherence to highly active antiretroviral therapy...
May 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28535241/management-of-depression-in-older-adults-a-review
#6
Rob M Kok, Charles F Reynolds
Importance: Depression in older adults is a common psychiatric disorder affecting their health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older, and its prevalence rises with increasing age. In addition, 10% to 15% of older adults have clinically significant depressive symptoms, even in the absence of major depression. Observations: Depression presents with the same symptoms in older adults as it does in younger populations...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28534022/mental-health-problems-in-parents-of-children-with-congenital-heart-disease
#7
REVIEW
Gerasimos A Kolaitis, Maya G Meentken, Elisabeth M W J Utens
This review will provide a concise description of mental health problems in parents of children with a (non-syndromic) congenital heart disease (CHD) during different stressful periods. Predictors of these problems and also implications for clinical practice will be mentioned. Having a child with CHD can be very stressful for parents, who have to face overwhelming emotions and also extra physical, financial, and other practical challenges. Parental distress has been reported in 30-80% of parents and appears not to be related to severity of CHD...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28533838/-predictive-factors-of-medication-adherence-in-patients-with-chronic-heart-failure-morocco-s-experience
#8
Yassine Ragbaoui, Imad Nouamou, Ayoub El Hammiri, Rachida Habbal
Medication adherence in patients with chronic heart failure is recognized as one of the major issues in the management of this pathology. Demographic status and socioeconomic conditions in African countries may have an impact on chronic heart failure treatment adherence. We conducted a cross-sectional study of patients with heart failure treated in the center of heart failure in the Department of Cardiology at the IBN ROCHD University Hospital (Morocco) from September 2014 to January 2015. The extent of medication adherence was based on a questionary: CARDIA-Questionary...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28532715/caretakers-barriers-to-pediatric-antiretroviral-therapy-adherence-in-vietnam-a-qualitative-and-quantitative-study
#9
C T Tran, T H Pham, K T Tran, T K C Nguyen, M Larsson
BACKGROUND: Poor antiretroviral therapy (ART) adherence leads to drug resistance and treatment failures. The options for second and third line ART regimens, particularly for pediatric patients, are very limited in low and middle-income countries. HIV-infected children are mostly passive drug-takers, thus caretakers play a very important role in assuring ART adherence. Pediatric ART adherence is still a challenging problem in Vietnam since non-adherence is the major risk factor for treatment failure...
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28532510/gender-differences-in-psychiatric-diagnoses-in-older-people-with-intellectual-disability-a-register-study
#10
Anna Axmon, Magnus Sandberg, Gerd Ahlström
BACKGROUND: Gender differences regarding psychiatric ill-health are well known in the general population. However, not much research is done on people with intellectual disability, and especially not among older people with intellectual disability. METHODS: People with intellectual disability aged 55+ years in 2012 in Sweden were identified through a register containing information on those receiving support and service for this type of disability. The cohort comprised 3609 women and 4327 men with mean age 65 and 64 years, respectively...
May 22, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28532277/temporal-parameters-of-post-stress-prophylactic-glucose-treatment-in-rats
#11
M A Conoscenti, E E Hart, N J Smith, T R Minor
Acute trauma can lead to life-long changes in susceptibility to psychiatric disease, such as Post-Traumatic Stress Disorder (PTSD). Rats given free access to a concentrated glucose solution for 24 hours beginning immediately after trauma failed to show stress-related pathology in the learned helplessness model of PTSD and comorbid major depression. We assessed effective dosing and temporal constraints of the glucose intervention in three experiments. We exposed 120 male Sprague-Dawley rats to 100, 1 mA, 3-15s, inescapable and unpredictable electric tail shocks (over a 110 minute period) or simple restraint in the learned helplessness procedure...
May 22, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28531848/a-systematic-review-and-meta-regression-of-the-prevalence-and-incidence-of-perinatal-depression
#12
REVIEW
C A Woody, A J Ferrari, D J Siskind, H A Whiteford, M G Harris
BACKGROUND: Major Depressive Disorder (MDD) is a leading cause of the disease burden for women of childbearing age, but the burden of MDD attributable to perinatal depression is not yet known. There has been little effort to date to systematically review available literature and produce global estimates of prevalence and incidence of perinatal depression. Enhanced understanding will help to guide resource allocation for screening and treatment. METHODS: A systematic literature review using the databases PsycINFO and PubMED returned 140 usable prevalence estimates from 96 studies...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28531768/rosa-damascena-oil-improved-sexual-function-and-testosterone-in-male-patients-with-opium-use-disorder-under-methadone-maintenance-therapy-results-from-a-double-blind-randomized-placebo-controlled-clinical-trial
#13
Vahid Farnia, Faeze Tatari, Mostafa Alikhani, Jalal Shakeri, Moshen Taghizadeh, Hassan Karbasizadeh, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
BACKGROUND: Some patients with opioid use disorder (OUD) are treated with methadone maintenance therapy (MMT). However, as with opioids, methadone has major side-effects; sexual dysfunction is a particularly distressing such effect. Rosa Damascena oil has been shown to reduce subjective sexual dysfunction in patients with major depressive disorders, but its influence on testosterone has not so far been tested. The aim of the present study was to investigate the influence of Rosa Damascena oil on sexual dysfunction and testosterone levels among male patients with OUD and undergoing MMT...
April 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28531646/lifetime-presence-of-psychotic-symptoms-in-bipolar-disorder-is-associated-with-less-favorable-socio-demographic-and-certain-clinical-features
#14
Bernardo Dell'Osso, Giulia Camuri, Laura Cremaschi, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. METHODS: The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153)...
April 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28531264/cariprazine-exhibits-anxiolytic-and-dopamine-d3-receptor-dependent-antidepressant-effects-in-the-chronic-stress-model
#15
Vanya Duric, Mounira Banasr, Tina Franklin, Ashley Lepack, Nika Adham, Béla Kiss, István Gyertyán, Ronald S Duman
Background: Cariprazine, a D3-preferring dopamine D2/D3 receptor partial agonist, is a new antipsychotic drug recently approved in the US for the treatment of schizophrenia and bipolar mania. We recently demonstrated that cariprazine also has significant anti-anhedonic-like effects in rats subjected to chronic stress; however, the exact mechanism of action for cariprazine's antidepressant-like properties is not known. Thus, in this study we examined whether the effects of cariprazine are mediated by dopamine D3 receptors...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28530876/research-continuous-surveillance-of-sleep-apnea-patients-in-a-medical-surgical-unit
#16
Dana Supe, Leah Baron, Tom Decker, Kyle Parker, Jeanne Venella, Sarah Williams, Kari Beaton, John Zaleski
This report consists of two separate studies on the use of continuous capnography monitoring conducted in an effort to improve patient safety at Virtua Health System. The desire for improved patient safety is motivating continuous monitoring and improved surveillance in clinical areas not traditionally equipped for such monitoring. We explored the use of remote monitoring of capnography, using enterprise middleware, in patients recovering from surgery in a medical-surgical unit. Continuous monitoring traditionally has been used in higher-acuity settings, such as intensive care units...
May 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28530341/-measuring-the-effect-of-multi-sensory-stimulation-in-the-snoezelen-room-on-sleep-quality-of-alzheimer-patients-using-actigraph
#17
Doron Todder, Meital Levartovsky, Tzvi Dwolatzky
BACKGROUND: The most common cause of dementia is Alzheimer's disease. The major manifestation of the disease is the cognitive impairment which appears at the onset of the disease. In addition to the cognitive impairment there are behavioral dysfunctions such as apathy, anxiety, depression and sleep disturbances. The treatment for the manifestations of Alzheimer is currently pharmacological and behavioral. One of the newest behavioral treatments for Alzheimer is the multi-sensory treatment using the Snoezelen room...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530238/micrornas-146a-b-5-and-425-3p-and-24-3p-are-markers-of-antidepressant-response-and-regulate-mapk-wnt-system-genes
#18
Juan Pablo Lopez, Laura M Fiori, Cristiana Cruceanu, Rixing Lin, Benoit Labonte, Hannah M Cates, Elizabeth A Heller, Vincent Vialou, Stacy M Ku, Christophe Gerald, Ming-Hu Han, Jane Foster, Benicio N Frey, Claudio N Soares, Daniel J Müller, Faranak Farzan, Francesco Leri, Glenda M MacQueen, Harriet Feilotter, Kathrin Tyryshkin, Kenneth R Evans, Peter Giacobbe, Pierre Blier, Raymond W Lam, Roumen Milev, Sagar V Parikh, Susan Rotzinger, Steven C Strother, Cathryn M Lewis, Katherine J Aitchison, Gayle M Wittenberg, Naguib Mechawar, Eric J Nestler, Rudolf Uher, Sidney H Kennedy, Gustavo Turecki
Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment. Our results revealed differential expression of miR-146a-5p, miR-146b-5p, miR-425-3p and miR-24-3p according to treatment response...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28529805/physical-activity-modulates-common-neuroplasticity-substrates-in-major-depressive-and-bipolar-disorder
#19
REVIEW
Cristy Phillips
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28529734/differential-regulation-of-mouse-and-human-mu-opioid-receptor-gene-depends-on-the-single-stranded-dna-structure-of-its-promoter-and-%C3%AE-complex-protein-1
#20
Dong-Sun Lee, Ping-Yee Law, Wei Ln, Horace H Loh, Kyu Young Song, Hack Sun Choi
The Mu opioid receptor (MOR) mediates various functions of opioid-induced analgesia, euphoria and respiratory depression, and is a major target of opioid analgesics. Understanding of MOR gene expression among species is important for understanding its analgesic function in humans. In the current study, the polypyrimidine/polypurine (PPy/u) region, a key element of MOR gene expression, was compared in humans and mice. The mouse PPy/u element is highly homologous to its human element (84%), and the mouse MOR (mMOR) reporter drives luciferase activity 35-fold more effectively than the human MOR (hMOR) reporter...
May 2017: Biomedical Reports
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