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Major depression

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https://www.readbyqxmd.com/read/27936453/biological-mechanisms-of-depression-following-treatment-with-interferon-for-chronic-hepatitis-c-a-critical-systematic-review
#1
REVIEW
Myrela O Machado, Giovanni Oriolo, Beatrice Bortolato, Cristiano A Köhler, Michael Maes, Marco Solmi, Iria Grande, Rocío Martín-Santos, Eduard Vieta, André F Carvalho
BACKGROUND: A significant subset of patients infected by the hepatitis C virus (HCV) develops a major depressive episode (MDE) during Interferon-alpha (IFN-α) based immunotherapy. We performed a systematic review of studies which examined biological mechanisms contributing to the onset of a MDE during IFN-α-based immunotherapy for HCV. METHODS: Major electronic databases were searched from inception up until 15th February 2016 for peer-reviewed prospective studies that had enrolled HCV infected patients who received IFN-α treatment...
November 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936452/exercise-is-an-effective-treatment-for-positive-valence-symptoms-in-major-depression
#2
Marisa Toups, Thomas Carmody, Tracy Greer, Chad Rethorst, Bruce Grannemann, Madhukar H Trivedi
INTRODUCTION: Measurement of symptoms domains and their response to treatment in relative isolation from diagnosed mental disorders has gained new urgency, as reflected by the National Institute of Mental Health's introduction of the Research Domain Criteria (RDoC). The Snaith Hamilton Pleasure Scale (SHAPS) and the Motivation and Energy Inventory (MEI) are two scales measuring positive valence symptoms. We evaluated the effect of exercise on positive valence symptoms of Major Depressive Disorder (MDD)...
October 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936439/symptoms-of-prolonged-grief-post-traumatic-stress-and-depression-after-loss-in-a-dutch-community-sample-a-latent-class-analysis
#3
A A A Manik J Djelantik, Geert E Smid, Rolf J Kleber, Paul A Boelen
Mental health problems following loss can manifest as heterogeneous symptomatology that may include symptoms of Prolonged Grief Disorder (PGD), Post-Traumatic Stress Disorder (PTSD), and Major Depressive Disorder (MDD). However, the co-occurrence of symptoms of these three disorders is still only partially explored. The aims of this study were to identify subgroups (i.e., classes) in a Dutch sample of bereaved individuals, based on severity and/or co-occurrence of symptoms and to identify predictors for these subgroups, taking into account all three disorders...
November 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27936078/associations-between-childhood-parental-mental-health-difficulties-and-depressive-symptoms-in-late-adulthood-the-influence-of-life-course-socioeconomic-health-and-lifestyle-factors
#4
Viola Angelini, Bart Klijs, Nynke Smidt, Jochen O Mierau
BACKGROUND: Depression among older adults (i.e., the 50+) is a major health concern. The objective of this study is to investigate whether growing up with a parent suffering from mental health problems is associated with depressive symptoms in late-adulthood and how this association is influenced by life-course socio-economic, health and lifestyle factors in childhood and late adulthood. METHODS: We used life-history data from the SHARE survey, consisting of 21,127 participants living in 13 European countries...
2016: PloS One
https://www.readbyqxmd.com/read/27935957/intracellular-zn-ii-intoxication-leads-to-dysregulation-of-the-perr-regulon-resulting-in-heme-toxicity-in-bacillus-subtilis
#5
Pete Chandrangsu, John D Helmann
Transition metal ions (Zn(II), Cu(II)/(I), Fe(III)/(II), Mn(II)) are essential for life and participate in a wide range of biological functions. Cellular Zn(II) levels must be high enough to ensure that it can perform its essential roles. Yet, since Zn(II) binds to ligands with high avidity, excess Zn(II) can lead to protein mismetallation. The major targets of mismetallation, and the underlying causes of Zn(II) intoxication, are not well understood. Here, we use a forward genetic selection to identify targets of Zn(II) toxicity...
December 9, 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27935809/assessing-and-measuring-cognitive-function-in-major-depressive-disorder
#6
Renee-Marie Ragguett, Danielle S Cha, Ron Kakar, Joshua D Rosenblat, Yena Lee, Roger S McIntyre
Cognitive dysfunction is a major component of major depressive disorder (MDD). No 'gold-standard' tool exists for the assessment of cognitive dysfunction for adults with MDD. The use of measurement-based care to improve treatment outcomes invites the need for a systematic screening, evaluation and measurement tool. The aim herein was to provide a succinct summary of literature documenting clinical implication of cognitive dysfunction in MDD, and a review of available screening, diagnostic and measurement tools for cognitive dysfunction in MDD is provided...
November 2016: Evidence-based Mental Health
https://www.readbyqxmd.com/read/27935459/hypnosis-in-the-treatment-of-major-depression-an-analysis-of-heart-rate-variability
#7
Xiuwen Chen, Rongqian Yang, Lulu Ge, Jie Luo, Ruixue Lv
Hypnosis is an adjuvant treatment of major depression (MD). Heart rate variability (HRV) can assess the autonomic nervous system, which is associated with MD, and HRV is decreased in MD patients. There is a lack of research on HRV changes before, during, and after the use of hypnosis in MD patients. A total of 21 MD patients participated in this study, and 5-minute electrocardiograms were recorded before, during, and after hypnosis. Compared with the prehypnotic condition, HRV parameters significantly (p < ...
January 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/27935392/sleep-disturbance-among-people-with-major-depressive-disorders-mdd-in-singapore
#8
Lee Seng Esmond Seow, Mythily Subramaniam, Edimansyah Abdin, Janhavi Ajit Vaingankar, Siow Ann Chong
BACKGROUND: Sleep problems are common with major depressive disorder (MDD), which has been identified as the most pervasive mental disorder in Singapore. AIMS: This study aimed to establish the prevalence of sleep disturbance among adults with lifetime and 12-month MDD, as well as its socio-demographic and clinical correlates. METHOD: Data were collected from the Singapore Mental Health Study, a cross-sectional epidemiological survey of the local residential population aged ≥18 years...
December 2016: Journal of Mental Health
https://www.readbyqxmd.com/read/27935247/focusing-on-situation-specific-expectations-in-major-depression-as-basis-for-behavioural-experiments-development-of-the-depressive-expectations-scale
#9
Tobias Kube, Lisa D'Astolfo, Julia A Glombiewski, Bettina K Doering, Winfried Rief
OBJECTIVES: Dysfunctional expectations are considered to be core features of various mental disorders. The aim of the study was to develop the Depressive Expectations Scale (DES) as a depression-specific measure for the assessment of dysfunctional expectations. Whereas previous research primarily focused on general cognitions and attitudes, the DES assesses 25 future-directed expectations (originally 75 items) which are situation-specific and falsifiable. DESIGN AND METHODS: To evaluate the psychometric properties of the DES, the scale was completed by 175 participants with and without severe depressive symptoms in an online survey...
December 9, 2016: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/27934881/the-relationship-between-cortical-inhibition-and-electroconvulsive-therapy-in-the-treatment-of-major-depressive-disorder
#10
Daphne Voineskos, Andrea J Levinson, Yinming Sun, Mera S Barr, Faranak Farzan, Tarek K Rajji, Paul B Fitzgerald, Daniel M Blumberger, Zafiris J Daskalakis
Dysfunctional cortical inhibition (CI) is postulated as a key neurophysiological mechanism in major depressive disorder. Electroconvulsive therapy (ECT) is the treatment of choice for resistant depression and ECT has been associated with enhanced CI. The objective of this study was to evaluate the relationship between CI and ECT response in resistant depression. Twenty-five patients with treatment resistant depression underwent an acute course of ECT. CI was indexed by the cortical silent period (CSP) and short-interval cortical inhibition (SICI), through TMS-EMG...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27933671/causal-inference-in-obesity-research
#11
REVIEW
P W Franks, N Atabaki-Pasdar
Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle and surgical interventions. Thus, whilst obesity is widely considered the major modifiable risk factor for many chronic diseases, its causes and consequences are often difficult to determine...
December 8, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27933018/a-study-of-the-coupling-of-fet-temperament-traits-with-major-depression
#12
Irina N Trofimova, William Sulis
Objective: Temperament and mental illness have been linked to the same systems of behavioral regulation. A temperament model, carefully structured to respond to subtle differences within systems of behavior regulation, should exhibit distinct temperament patterns in the presence of mental illness. Previous comparisons of temperament profiles in mental disorders used mostly emotionality-related traits. In contrast, the Functional Ensemble of Temperament (FET) model differentiates not only between emotionality traits, but also between traits related to physical, verbal, and mental aspects of behavior and maps 12 functional aspects of behavior to temperament traits as well as to symptoms of mental illnesses...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932948/rna-editing-systemic-relevance-and-clue-to-disease-mechanisms
#13
REVIEW
Jochen C Meier, Svenja Kankowski, Heinz Krestel, Florian Hetsch
Recent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with diseases such as atherosclerosis, myopathy, epilepsy, major depression disorder, schizophrenia and other mental disorders as well as cancer and brain tumors. This review article summarizes our current knowledge on that front and presents glycine receptor C-to-U RNA editing as a first example of disease-associated increased RNA editing that includes assessment of disease mechanisms of the corresponding gene product in an animal model...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27932864/efficacy-and-tolerability-of-vilazodone-for-major-depressive-disorder-evidence-from-phase-iii-iv-randomized-controlled-trials
#14
Ligen Shi, Jingyi Wang, Shenbin Xu, Yunrong Lu
Vilazodone is a new molecule approved for major depressive disorder (MDD). This report focuses on the efficacy and tolerability of vilazodone for MDD. MEDLINE, EMBASE, and Cochrane Library were searched. A total of 1,930 patients from four trials were included. A significant improvement in the Montgomery-Asberg Depression Rating Scale (MADRS) total score was seen as early as week 2 (P<0.01) in vilazodone-treated patients. The results showed a higher rate of MADRS response with vilazodone compared with placebo (P<0...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27931890/inpatients-with-major-depressive-disorder-psychometric-properties-of-the-new-multidimensional-depression-scale
#15
Mohammad Darharaj, Mojtaba Habibi, Michael J Power, Farzaneh Farzadian, Maesoumeh Rahimi, Habibeh Kholghi, Maryam Kazemitabar
The New Multi-dimensional Depression Scale (NMDS) is one of the most comprehensive scales that measures depression symptoms in four domains, including emotional, cognitive, somatic, and interpersonal. This study aimed to evaluate the factor structure and psychometric properties of the NMDS in a group of Iranian inpatients with Major Depressive Disorder (MDD). At first, the scale was translated into Persian and used as part of a battery consisting of the Beck Depression Inventory-II (BDI-II), Oxford Happiness Inventory (OHI), Beck Anxiety Inventory (BAI), and Short Form Health Survey (SF-36)...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#16
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
December 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27930698/major-depression-as-a-complex-dynamic-system
#17
Angélique O J Cramer, Claudia D van Borkulo, Erik J Giltay, Han L J van der Maas, Kenneth S Kendler, Marten Scheffer, Denny Borsboom
In this paper, we characterize major depression (MD) as a complex dynamic system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulting dynamics. With respect to architecture, we show that individuals vulnerable to developing MD are those with strong connections between symptoms: e.g., only one night of poor sleep suffices to make a particular person feel tired...
2016: PloS One
https://www.readbyqxmd.com/read/27930427/a-further-decrease-in-the-rates-of-administration-of-electroconvulsive-therapy-in-england
#18
Nicky Buley, Emma Copland, Sophie Hodge, Robert Chaplin
OBJECTIVES: Electroconvulsive therapy (ECT) is an effective treatment of major depression, and there have been consistent improvements in the administration of ECT in the past decade. However, studies have reported a steady decline in the rates of use of ECT in the United Kingdom and Ireland. Despite this, there has been no consistent record of how much ECT is being given or to whom it is given, for more than 20 years. The purpose of this study is to estimate the change in frequency of ECT use, the length of courses, patient demographics, and clinical outcomes between 2006 and 2 periods of 2012/2013 and 2014/2015...
December 7, 2016: Journal of ECT
https://www.readbyqxmd.com/read/27929611/switching-the-antidepressant-after-nonresponse-in-adults-with-major-depression-a-systematic-literature-search-and-meta-analysis
#19
Tom Bschor, Hannah Kern, Jonathan Henssler, Christopher Baethge
OBJECTIVE: Nonresponders to antidepressant monotherapy during acute treatment of major depression are often switched to a new antidepressant. The objective of this meta-analysis was to compare the efficacy of switching to a new antidepressant with continuation of the first antidepressant. DATA SOURCES: PubMed, Embase, PsycINFO, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and additional sources were systematically searched independently by 2 authors up to March 2015 without language limitations...
December 6, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27929610/antisuicidal-response-following-ketamine-infusion-is-associated-with-decreased-nighttime-wakefulness-in-major-depressive-disorder-and-bipolar-disorder
#20
Jennifer L Vande Voort, Elizabeth D Ballard, David A Luckenbaugh, Rebecca A Bernert, Erica M Richards, Mark J Niciu, Lawrence T Park, Rodrigo Machado-Vieira, Wallace C Duncan, Carlos A Zarate
OBJECTIVE: Insomnia and disrupted sleep are associated with increased risk of suicide. The N-methyl-D-aspartate antagonist ketamine has been associated with reduced suicidal thoughts, but the mechanism of action is unknown. This study sought to evaluate differences in nocturnal wakefulness in depressed individuals who did and did not have an antisuicidal response to ketamine. METHODS: Thirty-four participants with baseline suicidal ideation diagnosed with either DSM-IV major depressive disorder (n = 23) or bipolar depression (n = 11) between 2006 and 2013 completed nighttime electroencephalography (EEG) the night before and the night after a single ketamine infusion (0...
December 6, 2016: Journal of Clinical Psychiatry
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