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https://www.readbyqxmd.com/read/27934978/3d-printed-metal-molds-for-hot-embossing-plastic-microfluidic-devices
#1
Tung-Yi Lin, Truong Do, Patrick Kwon, Peter B Lillehoj
Plastics are one of the most commonly used materials for fabricating microfluidic devices. While various methods exist for fabricating plastic microdevices, hot embossing offers several unique advantages including high throughput, excellent compatibility with most thermoplastics and low start-up costs. However, hot embossing requires metal or silicon molds that are fabricated using CNC milling or microfabrication techniques which are time consuming, expensive and required skilled technicians. Here, we demonstrate for the first time the fabrication of plastic microchannels using 3D printed metal molds...
December 9, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27925175/to-expand-coverage-or-increase-frequency-quantifying-the-tradeoffs-between-equity-and-efficiency-facing-cervical-cancer-screening-programs-in-low-resource-settings
#2
Nicole G Campos, Vivien Tsu, Jose Jeronimo, Mercy Mvundura, Kyueun Lee, Jane J Kim
Cervical cancer is a leading cause of cancer death worldwide, with 85% of the disease burden residing in less developed regions. To inform evidence-based decision-making as cervical cancer screening programs are planned, implemented, and scaled in low- and middle-income countries, we used cost and test performance data from the START-UP demonstration project in Uganda and a microsimulation model of HPV infection and cervical carcinogenesis to quantify the health benefits, distributional equity, cost-effectiveness, and financial impact of either 1) improving access to cervical cancer screening or 2) increasing the number of lifetime screening opportunities for women who already have access...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27924346/bpcontrol-a-mobile-app-to-monitor-hypertensive-patients
#3
Adrian Carrera, Marc Pifarré, Jordi Vilaplana, Josep Cuadrado, Sara Solsona, Jordi Mateo, Francesc Solsona
BACKGROUND: Hypertension or high blood pressure is on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating this condition involves exhaustive monitoring of patients. The current mobile health services can be improved to perform this task more effectively. OBJECTIVE: To develop a useful, user-friendly, robust and efficient app, to monitor hypertensive patients and adapted to the particular requirements of hypertension...
December 7, 2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27914786/evaluating-the-feasibility-of-ratio-control-strategy-for-achieving-partial-nitritation-in-a-continuous-floccular-sludge-reactor-experimental-demonstration
#4
Wenru Liu, Dianhai Yang
To investigate the applicability of ratio control strategy to other systems, a continuous floccular sludge reactor was used in this study. It was found that nitrite accumulation was barely detected throughout 70days' investigation, being the average concentration in the effluent of 0.7±0.4mg/L. Batch experiments indicated that low dissolved oxygen (DO<0.3mg·L(-1)) greatly repressed the ammonium oxidizing bacteria (AOB) but only slightly inhibited the nitrite oxidizing bacteria (NOB). However, high-throughput sequencing revealed that the ratio of abundance between Nitrospira and Nitrosomonas, being the dominant NOB and AOB respectively, was considerably low (1...
November 25, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27914549/age-of-fusion-of-the-distal-radial-and-ulnar-epiphyses-from-hand-radiographs-a-study-in-kashmiri-population
#5
Nida Hassan, Farida Noor, Shabir Ahmad, Khalid Majid Fazili
Age estimation is a crucial parameter involved in investigations pertaining to civil and criminal procedures. It also aids in various examinations in forensic medicine, pediatrics, endocrinology and radiology. One of the important methods for skeletal age estimation is the age of fusion of the epiphyses. But there occur variations in the skeletal ages due to environmental, hormonal, ethnic and other factors. Hence, there arises the need for separate standards of ossification for different regions. The present study was conducted to ascertain the age of fusion of the distal radial and ulnar epiphyses in Kashmiri population...
December 2016: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/27913890/performance-improvement-of-raw-water-pretreatment-process-with-pre-inoculation-biofilm-feasibility-and-limiting-factors
#6
Guang-Feng Yang, Li-Juan Feng, Cai-Rong Guo, Tian Xia, Xiang-Yang Xu, Liang Zhu
The initial formation of biofilm and the removal performance of pollutants in biological pretreatment process for polluted raw water were limited due to the oligotrophic niche in raw water. In this study, the feasibility of using pre-inoculation biofilm formed under nutrients enhanced condition for polluted raw water treatment was analyzed in nine batch reactors. Results showed that the pollutants removal performance of biofilm was improved under nutrients enhanced conditions. Ammonia oxidation rate (AOR) was exponentially increased with the increasing in NH4(+)-N levels, and organic matter removal rate (ORR) was positively related to the initial total organic carbon (TOC) concentration...
December 2, 2016: Biodegradation
https://www.readbyqxmd.com/read/27910991/structural-fingerprints-of-yielding-mechanisms-in-attractive-colloidal-gels
#7
Arman Boromand, Safa Jamali, João M Maia
Core-Modified Dissipative Particle Dynamics (CM-DPD) with a modified depletion potential and full hydrodynamics description is used to study non-equilibrium properties of colloidal gels with short range attraction potentials at an intermediate volume fraction (ϕ = 0.2) under start-up shear deformation. Full structural and rheological analysis using the stress fabric tensor complemented by bond number and bond distribution evolution under flow reveals that similarly to dilute colloidal gels, flow-induced anisotropy and strain-induced stretching of bonds are present during the first yielding transition...
December 2, 2016: Soft Matter
https://www.readbyqxmd.com/read/27910540/the-thomson-scattering-system-at-wendelstein-7-x
#8
E Pasch, M N A Beurskens, S A Bozhenkov, G Fuchert, J Knauer, R C Wolf
This paper describes the design of the Thomson scattering system at the Wendelstein 7-X stellarator. For the first operation campaign we installed a 10 spatial channel system to cover a radial half profile of the plasma cross section. The start-up system is based on one Nd:YAG laser with 10 Hz repetition frequency, one observation optics, five fiber bundles with one delay line each, and five interference filter polychromators with five spectral channels and silicon avalanche diodes as detectors. High dynamic range analog to digital converters with 14 bit, 1 GS/s are used to digitize the signals...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27907997/control-of-oscillations-in-vibration-machines-start-up-and-passage-through-resonance
#9
A Fradkov, D Gorlatov, O Tomchina, D Tomchin
Control of oscillations in mechanical systems in the start-up and passage through resonance modes is studied. In both cases, the control algorithm is based on the speed-gradient method with energy-based goal functions. It is shown that for Hamiltonian 1-degree of freedom (DOF) systems, it is generically possible to move the system from any initial state to any final state by means of a controlling force of arbitrarily small intensity. Controlled passage through resonance is studied for a 5-DOF vibration machine taking friction into account...
November 2016: Chaos
https://www.readbyqxmd.com/read/27900438/start-up-and-bacterial-community-compositions-of-partial-nitrification-in-moving-bed-biofilm-reactor
#10
Tao Liu, Yan-Jun Mao, Yan-Ping Shi, Xie Quan
Partial nitrification (PN) has been considered as one of the promising processes for pretreatment of ammonium-rich wastewater. In this study, a kind of novel carriers with enhanced hydrophilicity and electrophilicity was implemented in a moving bed biofilm reactor (MBBR) to start up PN process. Results indicated that biofilm formation rate was higher on modified carriers. In comparison with the reactor filled with traditional carriers (start-up period of 21 days), it took only 14 days to start up PN successfully with ammonia removal efficiency and nitrite accumulation rate of 90 and 91%, respectively, in the reactor filled with modified carriers...
November 30, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27871433/regional-variation-in-acute-stroke-care-organisation
#11
Paula Muñoz Venturelli, Thompson Robinson, Pablo M Lavados, Verónica V Olavarría, Hisatomi Arima, Laurent Billot, Maree L Hackett, Joyce Y Lim, Sandy Middleton, Octavio Pontes-Neto, Bin Peng, Liying Cui, Lily Song, Gillian Mead, Caroline Watkins, Ruey-Tay Lin, Tsong-Hai Lee, Jeyaraj Pandian, H Asita de Silva, Craig S Anderson
BACKGROUND: Few studies have assessed regional variation in the organisation of stroke services, particularly health care resourcing, presence of protocols and discharge planning. Our aim was to compare stroke care organisation within middle- (MIC) and high-income country (HIC) hospitals participating in the Head Position in Stroke Trial (HeadPoST). METHODS: HeadPoST is an on-going international multicenter crossover cluster-randomized trial of 'sitting-up' versus 'lying-flat' head positioning in acute stroke...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27848211/simplified-novel-application-snapp-framework-a-guide-to-developing-and-implementing-second-generation-mobile-applications-for-behavioral-health-research
#12
Jennifer Fillo, B Lynette Staplefoote-Boynton, Angel Martinez, Lisa Sontag-Padilla, William G Shadel, Steven C Martino, Claude M Setodji, Daniella Meeker, Deborah Scharf
Advances in mobile technology and mobile applications (apps) have opened up an exciting new frontier for behavioral health researchers, with a "second generation" of apps allowing for the simultaneous collection of multiple streams of data in real time. With this comes a host of technical decisions and ethical considerations unique to this evolving approach to research. Drawing on our experience developing a second-generation app for the simultaneous collection of text message, voice, and self-report data, we provide a framework for researchers interested in developing and using second-generation mobile apps to study health behaviors...
December 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27847809/lack-of-associations-between-xpc-gene-polymorphisms-and-neuroblastoma-susceptibility-in-a-chinese-population
#13
Jintao Zheng, Ruizhong Zhang, Jinhong Zhu, Fenghua Wang, Tianyou Yang, Jing He, Huimin Xia
Neuroblastoma is one of the most malignant solid tumors in infants and young children. No more than 40% of neuroblastoma patients can survive for longer than five years after it has been diagnosed. XPC protein is a pivotal factor that recognizes DNA damage and starts up the nucleotide excision repair (NER) in mammalian cells. This makes up the first group to defend against the cancer. Previous studies have identified that XPC gene polymorphisms were associated with various types of cancer. However, the associations between XPC gene polymorphisms and neuroblastoma risk have not yet been studied...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27843513/bilateral-choroidal-metastases-from-endobronchial-carcinoid-treated-with-somatostatin-analogues
#14
Deborah De Bruyn, Jan Lamont, Erik Vanderstraeten, Simon Van Belle, Elise Platteau, Julie De Zaeytijd, Kristien P Hoornaert
OBJECTIVE: To describe a patient with bilateral multifocal choroidal metastases from an endobronchial carcinoid treated with a somatostatin analogue. METHOD: A 60-year-old woman presenting with photopsia in the left eye underwent an extensive ophthalmic examination, including fluorescein angiography, OCT and ultrasound. RESULTS: Fundoscopy revealed a small retinal tear in the left eye, for which she received laser treatment. In addition, choroidal masses were detected in both eyes...
2016: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/27836597/microbial-fuel-cell-anodic-microbial-population-dynamics-during-mfc-start-up
#15
Agathe Paitier, Alexiane Godain, Delina Lyon, Naoufel Haddour, Timothy M Vogel, Jean-Michel Monier
In order to optimize energy production in MFCs, a better understanding of anodic communities is essential. Our objective was to determine the taxonomic structure of the bacterial communities present at the surface of the anode during the formation and development of electro-active biofilms in MFCs inoculated with fresh primary clarifier overflow. Quantitative microbial community dynamics were evaluated as a function of time and electrical performance using 16S rRNA gene-based phylogenetic microarrays and flow cytometry...
November 2, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27830317/on-line-monitoring-of-methanol-and-methyl-formate-in-the-exhaust-gas-of-an-industrial-formaldehyde-production-plant-by-a-mid-ir-gas-sensor-based-on-tunable-fabry-p%C3%A3-rot-filter-technology
#16
Andreas Genner, Christoph Gasser, Harald Moser, Johannes Ofner, Josef Schreiber, Bernhard Lendl
On-line monitoring of key chemicals in an industrial production plant ensures economic operation, guarantees the desired product quality, and provides additional in-depth information on the involved chemical processes. For that purpose, rapid, rugged, and flexible measurement systems at reasonable cost are required. Here, we present the application of a flexible mid-IR filtometer for industrial gas sensing. The developed prototype consists of a modulated thermal infrared source, a temperature-controlled gas cell for absorption measurement and an integrated device consisting of a Fabry-Pérot interferometer and a pyroelectric mid-IR detector...
November 9, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27821112/power-fairness-and-trust-understanding-and-engaging-with-vaccine-trial-participants-and-communities-in-the-setting-up-the-ebovac-salone-vaccine-trial-in-sierra-leone
#17
Luisa Enria, Shelley Lees, Elizabeth Smout, Thomas Mooney, Angus F Tengbeh, Bailah Leigh, Brian Greenwood, Deborah Watson-Jones, Heidi Larson
BACKGROUND: This paper discusses the establishment of a clinical trial of an Ebola vaccine candidate in Kambia District, Northern Sierra Leone during the epidemic, and analyses the role of social science research in ensuring that lessons from the socio-political context, the recent experience of the Ebola outbreak, and learning from previous clinical trials were incorporated in the development of community engagement strategies. The paper aims to provide a case study of an integrated social science and communications system in the start-up phase of the clinical trial...
November 8, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27793307/funding-innovation-moving-the-business-forward
#18
Gary F Henry
Gary F. Henry is the Principal Consultant of G F Henry and Associates, a management consulting firm based in Charlottesville, Virginia. Mr. Henry has more than 30 years of distinguished experience, including CEO, CFO and COO roles in both established and start-up companies. Gary was named an Ernst & Young Virginia Entrepreneur of the Year in 2001.
November 2016: Surgery
https://www.readbyqxmd.com/read/27789891/highly-efficient-long-term-storage-of-carrier-bound-anammox-biomass
#19
Steffen Engelbrecht, Mbengamina Terence Fondengcap, Kristina Rathsack, Marion Martienssen
The anammox process is a potential alternative to the conventional nitrogen removal from wastewater. However, due to large generation times of anammox bacteria, the start-up of treatment reactors may be impeded. An efficient storage technique can handle this drawback and may be also suitable for seasonally operated treatment plants like in touristic areas. In the current study, several storage techniques were investigated with respect to its suitability for the preservation of the specific anammox activity after long-term storage...
October 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27769897/evaluating-a-novel-health-system-intervention-for-chronic-kidney-disease-care-using-the-re-aim-framework-insights-after-two-years
#20
Denise M Hynes, Michael J Fischer, Linda A Schiffer, Rani Gallardo, Ifeanyi Beverly Chukwudozie, Anna Porter, Michael Berbaum, Jennifer Earheart, Marian L Fitzgibbon
INTRODUCTION: Using a quasi-experimental design, we implemented the Patient-Centered Medical Home for Kidney Disease (PCMH-KD), a comprehensive, multidisciplinary care team to improve quality of life and healthcare coordination for adult chronic hemodialysis (CHD) patients. This paper highlights our experience in the first two years of the study. We focus on the process dimensions of Reach, Adoption, and Implementation within the context of the RE-AIM framework. MATERIALS AND METHODS: We established a new PCMH-KD model at two outpatient dialysis centers...
October 18, 2016: Contemporary Clinical Trials
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