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https://www.readbyqxmd.com/read/28209100/first-results-of-the-flemish-colorectal-cancer-screening-program%C3%A2-start-up-period-late-2013
#1
S Hoeck, S Pringels, E Kellen, K Van Herck, P Martens, E Van Limbergen, J Francart, G Francart
BACKGROUND AND AIMS: Investigation of the first participation rate and follow-up results of the Flemish colorectal cancer screening program. PATIENTS AND METHODS: In 2013 five age cohorts with an even age between 66 and 74 year old (n=243 335) were invited by mail to return a completed iFOBT. Participants who tested positive (≥75ng/ml) were referred to a follow-up colonoscopy. RESULTS: Participation rate was 48.4% (n=117 774). Overall positivity rate was 10...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28191967/evaluation-of-re-oxidation-thresholds-for-%C3%AE-al2o3-supported-cobalt-catalysts-under-fischer-tropsch-synthesis-conditions
#2
Nikolaos E Tsakoumis, John C Walmsley, Magnus Rønning, Wouter van Beek, Erling Rytter, Anders Holmen
Size dependent phenomena at the nanoscale influence many applications, notably in the science of heterogeneous catalysis. In cobalt based Fischer - Tropsch synthesis, the size of Co nanoparticles dictates to a high degree catalysts performance in terms of activity, selectivity and stability. Here, a highly dispersed Re/Co/γ-Al2O3 catalyst with high Co surface area per gram of catalyst was exposed to industrially relevant Fischer-Tropsch synthesis conditions and monitored in situ by synchrotron X-ray radiation...
February 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28169496/pdaucu-nanobranch-as-self-repair-electrocatalyst-for-oxygen-reduction-reaction
#3
Hongyu Gong, Xuecheng Cao, Fan Li, Yue Gong, Lin Gu, Rafael Gregorio Mendes, Mark H Rummeli, Peter Strasser, Ruizhi Yang
During start-up and shut-down operations of fuel cells, high potential is inevitably experienced at cathode, which leads to the deterioration of electrocatalyst for oxygen reduction reaction. The design of catalysts that can repair themselves under severe conditions has been identified as a primary challenge for fuel cells. Herein, self-supported PdAuCu branched nanostructure is synthesized by a hydrothermal method. By smartly utilizing the high potential treatment, the activity of PdAuCu is significantly enhanced due to the synergistic effect between the Pd and Cu (Ⅱ) generated by high potential treatment...
February 7, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28168528/rapid-start-up-of-nitrifying-mbbrs-at-low-temperatures-nitrification-biofilm-response-and-microbiome-analysis
#4
Bradley Young, Robert Delatolla, Turki Abujamel, Kevin Kennedy, Edith Laflamme, Alain Stintzi
The moving bed biofilm reactor (MBBR), operated as a post carbon removal system, requires long start-up times in comparison to carbon removal systems due to slow growing autotrophic organisms. This study investigates the use of carriers seeded in a carbon rich treatment system prior to inoculation in a nitrifying MBBR system to promote the rapid development of nitrifying biofilm in an MBBR system at temperatures between 6 and 8 °C. Results show that nitrification was initiated by the carbon removal carriers after 22 h of operation...
February 6, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28166897/field-tests-of-a-participatory-ergonomics-toolkit-for-total-worker-health
#5
Suzanne Nobrega, Laura Kernan, Bora Plaku-Alakbarova, Michelle Robertson, Nicholas Warren, Robert Henning
Growing interest in Total Worker Health(®) (TWH) programs to advance worker safety, health and well-being motivated development of a toolkit to guide their implementation. Iterative design of a program toolkit occurred in which participatory ergonomics (PE) served as the primary basis to plan integrated TWH interventions in four diverse organizations. The toolkit provided start-up guides for committee formation and training, and a structured PE process for generating integrated TWH interventions. Process data from program facilitators and participants throughout program implementation were used for iterative toolkit design...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28150747/methanol-independent-protein-expression-by-aox1-promoter-with-trans-acting-elements-engineering-and-glucose-glycerol-shift-induction-in-pichia-pastoris
#6
Jinjia Wang, Xiaolong Wang, Lei Shi, Fei Qi, Ping Zhang, Yuanxing Zhang, Xiangshan Zhou, Zhiwei Song, Menghao Cai
The alcohol oxidase 1 promoter (PAOX1) of Pichia pastoris is commonly used for high level expression of recombinant proteins. While the safety risk of methanol and tough process control for methanol induction usually cause problems especially in large-scale fermentation. By testing the functions of trans-acting elements of PAOX1 and combinatorially engineering of them, we successfully constructed a methanol-free PAOX1 start-up strain, in which, three transcription repressors were identified and deleted and, one transcription activator were overexpressed...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28131677/a-randomized-clinical-trial-to-evaluate-the-usefulness-of-amniotic-membrane-transplantation-in-bacterial-keratitis-healing
#7
Seyed Ali Tabatabaei, Mohammad Soleimani, Mahmoud Jabbarvand Behrouz, Ali Torkashvand, Pasha Anvari, Mehdi Yaseri
PURPOSE: To determine whether early amniotic membrane transplantation improves the outcomes among patients with bacterial keratitis. PATIENTS AND METHODS: In this prospective randomized clinical trial 49 eyes from 49 patients with bacterial keratitis received routine antibiotic therapy followed by double-layer amniotic membrane transplantation during 2-5 days after start up of the medications and the second group of 50 eyes from 50 patients only received routine antibacterial therapy...
January 25, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28120875/integrated-microfluidic-flow-through-microbial-fuel-cells
#8
Huawei Jiang, Md Azahar Ali, Zhen Xu, Larry J Halverson, Liang Dong
This paper reports on a miniaturized microbial fuel cell with a microfluidic flow-through configuration: a porous anolyte chamber is formed by filling a microfluidic chamber with three-dimensional graphene foam as anode, allowing nutritional medium to flow through the chamber to intimately interact with the colonized microbes on the scaffolds of the anode. No nutritional media flow over the anode. This allows sustaining high levels of nutrient utilization, minimizing consumption of nutritional substrates, and reducing response time of electricity generation owing to fast mass transport through pressure-driven flow and rapid diffusion of nutrients within the anode...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106846/competition-between-methanogens-and-acetogens-in-biocathodes-a-comparison-between-potentiostatic-and-galvanostatic-control
#9
Sam D Molenaar, Pradip Saha, Annemerel R Mol, Tom H J A Sleutels, Annemiek Ter Heijne, Cees J N Buisman
Microbial electrosynthesis is a useful form of technology for the renewable production of organic commodities from biologically catalyzed reduction of CO₂. However, for the technology to become applicable, process selectivity, stability and efficiency need strong improvement. Here we report on the effect of different electrochemical control modes (potentiostatic/galvanostatic) on both the start-up characteristics and steady-state performance of biocathodes using a non-enriched mixed-culture inoculum. Based on our results, it seems that kinetic differences exist between the two dominant functional microbial groups (i...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106420/long-lived-neighbors-determine-the-rheological-response-of-glasses
#10
M Laurati, P Maßhoff, K J Mutch, S U Egelhaaf, A Zaccone
Glasses exhibit a liquidlike structure but a solidlike rheological response with plastic deformations only occurring beyond yielding. Thus, predicting the rheological behavior from the microscopic structure is difficult, but important for materials science. Here, we consider colloidal suspensions and propose to supplement the static structural information with the local dynamics, namely, the rearrangement and breaking of the cage of neighbors. This is quantified by the mean squared nonaffine displacement and the number of particles that remain nearest neighbors for a long time, i...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28100095/shoulder-kinetics-during-start-up-and-propulsion-with-a-manual-wheelchair-within-the-initial-phase-of-uninstructed-training
#11
Samuel Hybois, Alice Siegel, Joseph Bascou, Nicolas Eydieux, Philippe Vaslin, Hélène Pillet, Pascale Fodé, Christophe Sauret
PURPOSE: Wheelchair locomotion is constraining for the upper limbs and involves a set of motor tasks that need to be learnt by a novice user. To understand this integration process, we investigated the evolution of shoulder kinetics during start-up and propulsion within the initial phase of low-intensity uninstructed training. MATERIALS AND METHODS: Seventeen novice able-bodied subjects performed a 120-min uninstructed practice distributed over 4 weeks. During the initial and final sessions, upper limbs kinematics and hand-rim kinetics were continuously collected...
January 19, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28092965/a-national-analysis-of-dental-waiting-lists-and-point-in-time-geographic-access-to-subsidised-dental-care-can-geographic-access-be-improved-by-offering-public-dental-care-through-private-dental-clinics
#12
Yevgeni Dudko, Estie Kruger, Marc Tennant
INTRODUCTION: Australia is one of the least densely populated countries in the world, with a population concentrated on or around coastal areas. Up to 33% of the Australian population are likely to have untreated dental decay, while people with inadequate dentition (fewer than 21 teeth) account for up to 34% of Australian adults. Historically, inadequate access to public dental care has resulted in long waiting lists, received much media coverage and been the subject of a new federal and state initiative...
January 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28088532/comparison-of-an-anaerobic-feed-and-split-anaerobic-aerobic-feed-on-granular-sludge-development-performance-and-ecology
#13
Benjamin J Thwaites, Petra Reeve, Nirmala Dinesh, Michael D Short, Ben van den Akker
The retrofitting of existing wastewater sequencing batch reactors (SBRs) to select for rapid-settling aerobic granular sludge (AGS) over floc-based conventional activated sludge (CAS), could be a viable option to decrease reactor cycle time and increase hydraulic capacity. Successful CAS-to-AGS conversion has previously been shown to be highly dependent on having a dedicated anaerobic feed, which presents additional engineering challenges when retrofitting SBRs. In this study we compared the performance of a split anaerobic-aerobic (An-Aer) feed with that of a traditional dedicated anaerobic feed regarding AGS formation and stability, nitrogen removal performance and microbial ecology...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28074571/screening-brief-intervention-and-referral-to-treatment-sbirt-implementation-barriers-facilitators-and-model-migration
#14
Janice Vendetti, Amanda Gmyrek, Donna Damon, Manu Singh, Bonnie McRee, Frances Del Boca
AIMS: To identify barriers and facilitators associated with initial implementation of a US alcohol and other substance use Screening, Brief Intervention, and Referral to Treatment (SBIRT) grant program, and to identify modifications in program design that addressed implementation challenges. DESIGN: A mixed-method approach used quantitative and qualitative data, including SBIRT provider ratings of implementation barriers and facilitators, staff interview responses and program documentation...
February 2017: Addiction
https://www.readbyqxmd.com/read/28074565/sustaining-screening-brief-intervention-and-referral-to-treatment-sbirt-services-in-health-care-settings
#15
Manu Singh, Amanda Gmyrek, Amy Hernandez, Donna Damon, Susan Hayashi
AIMS: To assess the sustainability of Screening, Brief Intervention and Referral to Treatment (SBIRT) services after cessation of initial start-up funding. DESIGN: Descriptive study with quantitative and qualitative data collected from 34 staff participants from six grantees (comprising 103 sites) funded previously through a large, federally supported SBIRT program. SETTING: Primary care out-patient clinics and hospitals in the United States...
February 2017: Addiction
https://www.readbyqxmd.com/read/28069357/control-strategies-for-drug-product-continuous-direct-compression-state-of-control-product-collection-strategies-and-startup-shutdown-operations-for-the-production-of-clinical-trial-materials-and-commercial-products
#16
Ahmad Almaya, Lawrence De Belder, Robert Meyer, Karthik Nagapudi, Hung-Ren Homer Lin, Ian Leavesley, Jayanthy Jayanth, Gurjit Bajwa, James DiNunzio, Anthony Tantuccio, Dan Blackwood, Admassu Abebe
Continuous manufacturing (CM) has emerged in the pharmaceutical industry as a paradigm shift with significant advantages related to cost, efficiency, flexibility, and higher assurance of quality. The inherent differences from batch processes justify examining the CM control strategy more holistically. This article describes the current thinking for the control and implementation of CM, using the example of a direct compression process and taking into consideration the ICH Q10 definition of "state of control" and process validation requirements...
January 6, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28063283/microbial-community-redundancy-in-anaerobic-digestion-drives-process-recovery-after-salinity-exposure
#17
Jo De Vrieze, Marlies E R Christiaens, Diego Walraedt, Arno Devooght, Umer Zeeshan Ijaz, Nico Boon
Anaerobic digestion of high-salinity wastewaters often results in process inhibition due to the susceptibility of the methanogenic archaea. The ability of the microbial community to deal with increased salinity levels is of high importance to ensure process perseverance or recovery after failure. The exact strategy of the microbial community to ensure process endurance is, however, often unknown. In this study, we investigated how the microbial community is able to recover process performance following a disturbance through the application of high-salinity molasses wastewater...
December 26, 2016: Water Research
https://www.readbyqxmd.com/read/28062091/effects-of-person-centred-care-on-health-outcomes-a-randomized-controlled-trial-in-patients-with-acute-coronary-syndrome
#18
Laura Pirhonen, Elisabeth Hansson Olofsson, Andreas Fors, Inger Ekman, Kristian Bolin
OBJECTIVES: To study the effects of person-centred care provided to patients with acute coronary syndrome, using four different health-related outcome measures. Also, to examine the performance of these outcomes when measuring person-centred care. DATA AND METHOD: The data used in this study consists of primary data from a multicentre randomized parallel group, controlled intervention study for patients with acute coronary syndrome at Sahlgrenska University Hospital in Gothenburg, Sweden...
February 2017: Health Policy
https://www.readbyqxmd.com/read/28057558/characterization-of-the-planktonic-microbiome-in-upflow-anaerobic-sludge-blanket-reactors-during-adaptation-of-mesophilic-methanogenic-granules-to-thermophilic-operational-conditions
#19
Xinyu Zhu, Laura Treu, Panagiotis G Kougias, Stefano Campanaro, Irini Angelidaki
Upflow anaerobic sludge blanket (UASB) technology refers to reactor technology where granules, i.e. self-immobilised microbial associations, are the biological catalysts involved in the anaerobic digestion process. During the start-up period, UASB reactors operate at relatively long HRT and therefore the liquid phase of the reactor becomes a favourable environment for microbial growth. The current study aimed to elucidate the dynamicity of the suspended microbial community in UASB reactors, during the transition from mesophilic to thermophilic conditions...
January 2, 2017: Anaerobe
https://www.readbyqxmd.com/read/28057414/apoe-apoe-receptors-and-the-synapse-in-alzheimer-s-disease
#20
REVIEW
Courtney Lane-Donovan, Joachim Herz
As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are becoming a significant burden on patients, their families, and health-care systems. Neurodegenerative processes may start up to 15 years before outward signs and symptoms of AD, as evidenced by data from AD patients and mouse models. A major genetic risk factor for late-onset AD is the ɛ4 isoform of apolipoprotein E (ApoE4), which is present in almost 20% of the population. In this review we discuss the contribution of ApoE receptor signaling to the function of each component of the tripartite synapse - the axon terminal, the postsynaptic dendritic spine, and the astrocyte - and examine how these systems fail in the context of ApoE4 and AD...
January 2, 2017: Trends in Endocrinology and Metabolism: TEM
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