Xiaowen Gong, Tianyuan Hu, Qiujin Shen, Luyang Zhang, Wei Zhang, Xueou Liu, Suyu Zong, Xiaoyun Li, Tiantian Wang, Wen Yan, Yu Hu, Xiaoli Chen, Jiarui Zheng, Aoli Zhang, Junxia Wang, Yahui Feng, Chengwen Li, Jiao Ma, Xin Gao, Zhen Song, Yingchi Zhang, Robert Peter Gale, Xiaofan Zhu, Junren Chen
ETV6 :: RUNX1 is the most common fusion gene in childhood acute lymphoblastic leukaemia (ALL) and is associated with favorable outcomes, especially in low-risk children. However, as many as 10% of children relapse within 3 years, and such early relapses have poor survival. Identifying children at risk for early relapse is an important challenge. We interrogated data from 87 children with low-risk ETV6 :: RUNX1 -positive B-cell ALL and with available preserved bone marrow samples (discovery cohort). We profiled somatic point mutations in a panel of 559 genes and genome-wide transcriptome and single-nucleotide variants...
April 2024: EJHaem