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Bone Fusion

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https://www.readbyqxmd.com/read/29035584/hybrid-fixation-for-ankle-fusion-in-diabetic-charcot-arthropathy
#1
Hani El-Mowafi, Mazen Abulsaad, Yasser Kandil, Ahmed El-Hawary, Samer Ali
BACKGROUND: Ankle fusion is difficult to achieve in the diabetic Charcot ankle Brodsky type 3a because of the poor quality of the bone and the inability to achieve a stable biomechanical construct. The aim of this study was to report the outcome of ankle fusion using a combination of an intramedullary nail and a circular external fixator in patients with diabetic Charcot arthropathy. METHODS: We prospectively studied 24 patients with diabetic Charcot arthropathy of the ankle who were treated by fusion of the tibiotalar joint using a combined retrograde intramedullary nail and Ilizarov external fixator...
October 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29032221/-spontaneous-fusion-of-s2-s3-spondyloptosis-in-an-adult-a-case-report
#2
Payman Vahedi, George N Rymarczuk, John L Gillick, R Shane Tubbs, Jefferson Wilson, Srinivas K Prasad
Spondyloptosis is grade V on the Meyerding classification. Traumatic spondyloptosis can occur throughout the spinal column, particularly at junctional levels, and finding the ideal surgical strategy to address it remains a challenge for spinal surgeons. The sacrum is considered a united bone in adults and sacral inter-segmental spondyloptosis is extremely rare. Herein, we present a very unusual case of S2/S3 spondyloptosis in a 27-year-old female patient with spontaneous solid fusion and we discuss the relevant literature...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29030741/the-role-of-next-generation-sequencing-in-sarcomas-evolution-from-light-microscope-to-molecular-microscope
#3
REVIEW
Roman Groisberg, Jason Roszik, Anthony Conley, Shreyaskumar R Patel, Vivek Subbiah
PURPOSE OF REVIEW: Sarcomas are rare, heterogeneous group of soft tissue and bone tumors. Precise diagnosis of specific subtypes is challenging using conventional methods. Herein, we review the role of next-generation sequencing (NGS) technology that is used for rapid sequencing of DNA and RNA. RECENT FINDINGS: Recent sarcoma specific studies recommend that molecular genetic testing should be added at diagnosis for appropriate clinical management in addition to diagnosis by expert pathologists...
October 13, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/29030231/als-associated-mutation-sod1-g93a-leads-to-abnormal-mitochondrial-dynamics-in-osteocytes
#4
Huan Wang, Jianxun Yi, Xuejun Li, Yajuan Xiao, Kamal Dhakal, Jingsong Zhou
While the death of motor neuron is a pathological hallmark of amyotrophic lateral sclerosis (ALS), defects in other cell types or organs may also actively contribute to ALS disease progression. ALS patients experience progressive skeletal muscle wasting that may not only exacerbate neuronal degeneration, but likely has a significant impact on bone function. In our previous published study, we have discovered severe bone loss in an ALS mouse model with overexpression of ALS-associated mutation SOD1(G93A) (G93A)...
October 10, 2017: Bone
https://www.readbyqxmd.com/read/29026643/mineralized-collagen-artificial-bone-repair-material-products-used-for-fusing-the-podarthral-joints-with-internal-fixation-a-case-report
#5
Nihar S Ghate, Helen Cui
In this study, we reported a case with collapse and subluxation of metatarsal-cuneiform joint, navicular-cuneiform joint with subluxed the right first metatarsophalangeal joint. The injured medial column was internally fixed with compression arthrodesis. The fusion site was firmed up with BonGold® Bone Sponge and Bone Putty. The prognosis of fused navicular-cuneiform joint and metatarsal-cuneiform joint were examined by X-ray shortly after surgical operation and followed up 2, 4, 6, 9 and 13 weeks after the surgical operation...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29025582/a-novel-trip11-flt3-fusion-in-a-patient-with-a-myeloid-lymphoid-neoplasm-with-eosinophilia
#6
Alfred Chung, Yanli Hou, Robert S Ohgami, Ann Von Gehr, Dianna G Fisk, Krishna M Roskin, Xu Li, Linda Gojenola, Charles D Bangs, Daniel A Arber, Andrew Z Fire, Athena M Cherry, James L Zehnder, Jason Gotlib, Jason D Merker
FLT3 fusions are associated with myeloid and lymphoid neoplasms with eosinophilia. We describe a patient presenting with clinicopathologic features of both chronic eosinophilic leukemia, not otherwise specified (CEL, NOS) and systemic mastocytosis (SM). The bone marrow demonstrated a myeloproliferative neoplasm with eosinophilia and aggregates of atypical mast cells. Cytogenetic analysis revealed a t(13;14)(q12;q32), which was subsequently molecularly characterized as a novel TRIP11-FLT3 rearrangement. A KIT D816V mutation was also identified...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29021995/tumor-induced-osteomalacia
#7
Pablo Florenzano, Rachel I Gafni, Michael T Collins
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness. It is caused by tumoral overproduction of fibroblast growth factor 23 (FGF23) that acts primarily at the proximal renal tubule, decreasing phosphate reabsorption and 1α-hydroxylation of 25 hydroxyvitamin D, thus producing hypophosphatemia and osteomalacia. Lesions are typically small, benign mesenchymal tumors that may be found in bone or soft tissue, anywhere in the body...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29021566/high-throughput-screens-using-photo-highlighting-discover-bmp-signaling-in-mitochondrial-lipid-oxidation
#8
Yong Yu, Ayse Sena Mutlu, Harrison Liu, Meng C Wang
High-throughput screens at microscopic resolution can uncover molecular mechanisms of cellular dynamics, but remain technically challenging in live multicellular organisms. Here we present a genetic screening method using photo-highlighting for candidate selection on microscopes. We apply this method to stimulated Raman scattering (SRS) microscopy and systematically identify 57 Caenorhabditis elegans mutants with altered lipid distribution. Four of these mutants target the components of the Bone Morphogenetic Protein (BMP) signaling pathway, revealing that BMP signaling inactivation causes exhaustion of lipid reserves in somatic tissues...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29018937/local-effect-of-zoledronic-acid-on-new-bone-formation-in-posterolateral-spinal-fusion-with-demineralized-bone-matrix-in-a-murine-model
#9
Pawel Zwolak, Jan Farei-Campagna, Thorsten Jentzsch, Brigitte von Rechenberg, Clément M Werner
BACKGROUND: Posterolateral spinal fusion is a common orthopaedic surgery performed to treat degenerative and traumatic deformities of the spinal column. In posteriolateral spinal fusion, different osteoinductive demineralized bone matrix products have been previously investigated. We evaluated the effect of locally applied zoledronic acid in combination with commercially available demineralized bone matrix putty on new bone formation in posterolateral spinal fusion in a murine in vivo model...
October 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29017980/predisposing-factors-of-fracture-nonunion-after-posterior-c1-lateral-mass-screws-combined-with-c2-pedicle-laminar-screws-fixation-for-type-ii-odontoid-fracture
#10
Hui Wang
INTRODUCTION: The aim of this study was to explore the predisposing factors for fracture nonunion after C1 lateral screw combined with C2 pedicle/laminar screw for type II odontoid fracture, and hope to provide references in decision making and surgical planning for spinal surgeons. METHODS: This is a retrospective study. By retrieving the medical records from January 2010 to July 2015 in our hospital, 117 type II odontoid fracture patients were reviewed. According to the occurrence of fracture union at the final follow up, patients were divided into two groups: Union group and Non-union group...
October 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29016438/ono-1301-enhances-in-vitro-osteoblast-differentiation-and-in-vivo-bone-formation-induced-by-bone-morphogenetic-protein
#11
Sadaaki Kanayama, Takashi Kaito, Kazuma Kitaguchi, Hiroyuki Ishiguro, Kunihiko Hashimoto, Ryota Chijimatsu, Satoru Otsuru, Shota Takenaka, Takahiro Makino, Yusuke Sakai, Akira Myoui, Hideki Yoshikawa
STUDY DESIGN: In vitro and in vivo assessment of osteogenic effect by prostacyclin agonist (ONO-1301) OBJECTIVE.: To investigate the effects of ONO-1301 on in vitro osteoblastic differentiation and in vivo bone formation induced by bone morphogenetic protein (BMP). SUMMARY OF BACKGROUND DATA: Among prostaglandins (PGs), PGE2 is the most abundant in bone tissue and its effects on bone formation have been well studied. PGI2 (prostacyclin) is the second most abundant PG in bone tissue and plays important roles in hemodynamics...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28993889/recurrent-primary-osseous-hemangiopericytoma-in-the-thoracic-spine-a-case-report-and-literature-review
#12
Takahiro Onoki, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa
PURPOSE: Primary osseous hemangiopericytoma (HPC) of the spine is exceedingly rare. HPC has malignant potential and has the capacity for metastasis and local recurrence. We herein present the first case of recurrent primary osseous HPC in the thoracic spine that was successfully treated by total spondylectomy at three vertebral levels and spinal reconstruction. METHODS: We performed a two-stage operation for recurrent HPC using anterior and posterior approaches at the T5-T7 vertebrae...
October 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28992519/posterior-atlantoaxial-fusion-with-a-screw-rod-system-allograft-versus-iliac-crest-autograft
#13
Da-Geng Huang, Xin-Liang Zhang, Ding-Jun Hao, Cheng-Cheng Yu, Bai-Bing Mi, Qi-Ling Yuan, Bao-Rong He, Tuan-Jiang Liu, Hua Guo, Xiao-Dong Wang
OBJECTIVE: To compare the effectiveness of allograft and iliac crest autograft in atlantoaxial fusion. PATIENTS AND METHODS: Between January 2012 and December 2012, 41 consecutive patients underwent posterior atlantoaxial fusion with a screw-rod fixation system in our spine center. The choice to use allograft or iliac crest autograft was made by the patient himself or herself after being informed about the advantages and disadvantages of both methods. In the allograft group, we used mixed material of morcellized demineralized freeze-dried bone allograft and local autograft for posterior atlantoaxial fusion...
October 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28989849/can-posterior-lumbar-instrumentation-and-fusion-be-overpowered-by-anterior-lumbar-fusion-with-hyperlordotic-cages-a-cadaveric-study
#14
Nathan Wigner, Abhijeet Kadam, Philip Saville, Vincent Arlet
STUDY DESIGN: Technical report on cadavers. OBJECTIVE: To evaluate preliminary feasibility and safety of lumbar sagittal alignment correction with anterior hyperlordotic cages used to overpower previous posterior spinal instrumentation. METHODS: Hyperlordotic 30° anterior lumbar interbody fusion (ALIF) cages were inserted in collapsed L5-S1 disc space of 2 cadavers to overpower prior posterior L5-S1 pedicle screws and rod constructs. A distinct technique of opening up the disc space and creation of intersegmental lordosis was employed using a large endplate distractor and transforaminal lumbar interbody fusion (TLIF) paddle distractor...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28989840/trends-analysis-of-rhbmp-utilization-in-single-level-posterior-lumbar-interbody-fusion-in-the-united-states
#15
Lifeng Lao, Jeremiah R Cohen, Zorica Buser, Darrel S Brodke, Jim A Youssef, Jong-Beom Park, S Tim Yoon, Jeffrey C Wang, Hans-Joerg Meisel
STUDY DESIGN: Retrospective study. OBJECTIVES: Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used in spinal fusion surgery, but there is little information on rhBMP-2 utilization in single-level posterior lumbar interbody fusion (PLIF). The purpose of our study was to evaluate the trends and demographics of rhBMP-2 utilization in single-level PLIF. METHODS: Patients who underwent single-level PLIF from 2005 to 2011 were identified by searching ICD-9 diagnosis and procedure codes in the PearlDiver Patient Records Database, a national database of orthopedic insurance records...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28989837/trends-costs-and-complications-of-anterior-cervical-discectomy-and-fusion-with-and-without-bone-morphogenetic-protein-in-the-united-states-medicare-population
#16
REVIEW
Elizabeth L Lord, Jeremiah R Cohen, Zorica Buser, Hans-Joerg Meisel, Darrel S Brodke, S Tim Yoon, Jim A Youssef, Jeffrey C Wang, Jong-Beom Park
STUDY DESIGN: Retrospective database review. OBJECTIVES: After the Food and Drug Administration approved bone morphogenetic protein-2 (BMP) in 2002, BMP was used off-label in the cervical spine to increase bone growth and bony fusion. Since then, concerns have been raised regarding complication rates and safety. This study was conducted to examine the use of BMP in anterior cervical discectomy and fusion (ACDF) in the Medicare population and to determine risk of complications and associated costs within 90 days of surgery...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28986227/anterior-cervical-discectomy-with-instrumented-allograft-fusion-lordosis-restoration-and-comparison-of-functional-outcomes-among-patients-of-different-age-groups
#17
Dario Muzevic, Bruno Splavski, Frederick A Boop, Kenan I Arnautovic
OBJECTIVE: To investigate clinical parameters of anterior cervical discectomy and fusion (ACDF) treatment and outcomes using osseous allograft in different age groups, study postoperative results of restoring of lordosis, and evaluate the utility of bone allografts for ACDF, including graft subsidence. METHODS: We reviewed data from 154 patients having clinical symptoms and radiological signs of disc herniation and/or cervical spondylosis. Decompression was achieved through discectomy, osteophyte ablation, endplate drilling, and foraminotomy...
October 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28979589/ulna-autograft-for-wrist-arthrodesis-a-novel-approach-in-failed-wrist-arthoplasty
#18
Nastaran Sargazi, M Philpott, A Malik, M Waseem
Rheumatoid arthritis is a polyarthropathy affecting approximately 1% of the population worldwide. Wrist involvement is observed around 75% of patients, resulting in substantial disability and morbidity. A multidisciplinary approach to management of such patients is undertaken to prevent disease progression, many go on to develop debilitating disease requiring surgical intervention. Total wrist arthroplasty and arthrodesis are the main options available for those with end-stage disease, with arthroplasty preferred due to its ability to preserve a good degree of wrist function...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28979586/percutaneous-first-metatarsophalangeal-joint-fusion
#19
Thomas Bauer
The first metatarsophalangeal (MTP1) joint fusion is a very useful procedure in forefoot surgery and is still the gold standard for the treatment of severe and painful hallux rigidus. Normal walking and running are possible after MTP1 fusion, the first ray mobility being essentially in the interphalangeal (IP) joint with a compensatory hypermobility in dorsal flexion. Percutaneous MTP1 fusion is a simple procedure providing comparable results to fusions performed with open techniques. Postoperative cares are simplified with an immediate full weight bearing on rigid flat shoes and quick return to normal walking...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28978095/melphalan-modifies-the-bone-microenvironment-by-enhancing-osteoclast-formation
#20
Ryan C Chai, Michelle M McDonald, Rachael L Terry, Nataša Kovačić, Jenny M Down, Jessica A Pettitt, Sindhu T Mohanty, Shruti Shah, Gholamreza Haffari, Jiake Xu, Matthew T Gillespie, Michael J Rogers, John T Price, Peter I Croucher, Julian M W Quinn
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development. Dormant MM cells can be reactivated after melphalan treatment; however, it is unclear whether melphalan treatment increases osteoclast formation to modify the endosteal niche. Melphalan treatment of mice for 14 days decreased bone volume and the endosteal bone surface, and this was associated with increases in osteoclast numbers...
September 15, 2017: Oncotarget
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