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https://www.readbyqxmd.com/read/28431955/the-course-of-modic-vertebral-body-changes-after-posterolateral-lumbar-fusion-on-fused-and-adjacent-levels-a-systematic-review-of-the-literature
#1
REVIEW
Stella Taylor Portella, Marcus André Acioly
According to the original description by Modic et al., the natural course of bone marrow signal abnormalities is an inexorable, progressive one, however recent evidence has demonstrated in healthy individuals and those suffering from lumbar disc herniation that the course of endplate degenerative changes is rather dynamic and sometimes regressive. The evolution of such changes in lumbar fused segments and adjacent levels is largely unknown. The literature relevant to the course of Modic changes on fused and adjacent levels, as well as its clinical correspondence in patients undergoing posterolateral lumbar fusion was collected...
April 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28429277/primary-ewing-sarcoma-primitive-neuroectodermal-tumor-of-the-kidney-a-clinicopathologic-study-of-23-cases
#2
Paari Murugan, Priya Rao, Pheroze Tamboli, Bogdan Czerniak, Charles C Guo
Primary Ewing sarcoma / primitive neuroectodermal tumor (ES) of the kidney is a rare neoplasm with limited clinicopathologic data. We report 23 such cases with no history of ES elsewhere in the body. The patients included 13 male and 10 female, aged 8-70 years (mean, 31 years). The average tumor size was 11.7 cm (range, 5-20 cm). Microscopic analysis showed predominantly lobular growth (n = 14), with focal papillary (n = 3), alveolar (n = 1), and hemangiopericytoma-like (n = 1) patterns. Several tumors (n = 11) exhibited robust mitotic activity (>10 mitoses/10 high-power fields)...
April 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28428912/biomechanical-evaluation-of-carpal-kinematics-during-simulated-wrist-motion
#3
Helen Stoesser, Clare E Padmore, Masao Nishiwaki, Braden Gammon, G Daniel G Langohr, James A Johnson
Background Flexion and extension of the wrist is achieved primarily at the radiocarpal and midcarpal joints. Carpal kinematics have been investigated, although there remains no consensus regarding the relative contribution of each bone to wrist motion. Purpose To determine the kinematics of the scaphoid, lunate, and capitate during unconstrained simulated wrist flexion/extension and to examine the effect of motion direction on the contribution of each bone. Materials and Methods Seven cadaveric upper extremities were tested in a passive wrist simulator with 10N tone loads applied to the wrist flexors/extensors...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28419312/minimally-invasive-transforaminal-lumbar-interbody-fusion-meta-analysis-of-the-fusion-rates-what-is-the-optimal-graft-material
#4
Avelino Parajón, Marjan Alimi, Rodrigo Navarro-Ramirez, Paul Christos, Jose M Torres-Campa, Yu Moriguchi, Gernot Lang, Roger Härtl
BACKGROUND: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is an increasingly popular procedure with several potential advantages over traditional open TLIF. OBJECTIVE: The current study aimed to compare fusion rates of different graft materials used in MIS-TLIF, via meta-analysis of the published literature. METHODS: A Medline search was performed and a database was created including patient's type of graft, clinical outcome, fusion rate, fusion assessment modality, and duration of follow-up...
April 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28418093/hypoxia-inducible-factor-1-alpha-does-not-regulate-osteoclastogenesis-but-enhances-bone-resorption-activity-via-prolyl-4-hydroxylase-2
#5
Philippa A Hulley, Tammie Bishop, Aude Vernet, Jurgen E Schneider, James R Edwards, Nick A Athanasou, Helen J Knowles
Osteogenic-angiogenic coupling is promoted by the Hypoxia-Inducible Factor 1-alpha (HIF-1α) transcription factor, provoking interest in HIF activation as a therapeutic strategy to improve osteoblast mineralisation and treat pathological osteolysis. However, HIF also enhances the bone resorbing activity of mature osteoclasts. It is therefore essential to determine the full effect(s) of HIF on both the formation and bone-resorbing function of osteoclasts in order to understand how they might respond to such a strategy...
April 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28416835/-polymethylmethacrylate-augmentation-of-bone-cement-injectable-cannulated-pedicle-screws-was-used-to-treat-degenerative-lumbar-scoliosis-with-osteoporosis
#6
H L Sun, C D Li, X W Li, X D Yi, H Liu, H L Lu, H Li, Z R Yu, Y Wang
OBJECTIVE: To describe the application of polymethylmethacrylate (PMMA) augmentation of cement-injectable cannulated pedicle screws for the treatment of degenerative lumbar scoliosis with osteoporosis. METHODS: Retrospective cohort study was used to compare cement injectable cannulated pedicle screws (CICPs) group with PMMA augmentation and control group with traditional method in the correction surgery for Lenke-silva level III and level IV degenerative scoliosis cases with osteoporosis...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28416462/clinical-assessment-of-115-cases-of-hindfoot-fusion-with-two-different-types-of-graft-allograft-dbm-bone-marrow-aspirate-versus-autograft-dbm
#7
Mathias Tricot, Paul-André Deleu, Christine Detrembleur, Thibaut Leemrijse
INTRODUCTION: Nonunion is a common complication (15%) of hindfoot and ankle arthrodesis. Autograft can improve the fusion rate because of its osteoconductive, osteoinductive and osteogenic properties. However, autograft harvesting is a source of morbidity. One alternative is to combine allograft with demineralized bone matrix (DBM) and iliac bone marrow aspirate (BMA). This combination graft has similar biological properties to healthy bone. When used alone, allograft has osteoconductive and sometimes structural properties...
April 14, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28415797/rab7-gtpase-controls-lipid-metabolic-signaling-in-myeloid-derived-suppressor-cells
#8
Xinchun Ding, Wenjing Zhang, Ting Zhao, Cong Yan, Hong Du
Lysosomal acid lipase (LAL) is a critical neutral lipid metabolic enzyme that regulates metabolic reprogramming in myeloid-derived suppressor cells (MDSCs) through over-activation of mammalian target of rapamycin (mTOR). Affymetrix GeneChip microarray analysis of MDSCs from LAL deficient mouse (lal-/-) revealed upregulation of Rab7 GTPase protein, which belongs to a superfamily of small-molecular-weight GTPase known to regulate intracellular membrane trafficking from early to late endosomes and lysosomes. Here, the physical protein-protein interaction between Rab7 GTPase and mTOR has been detected by co-immunoprecipitation in the cell extract of wild type HD1A and lal-/- MDSC-like HD1B myeloid cell lines...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413721/aspects-of-gorgonopsian-paleobiology-and-evolution-insights-from-the-basicranium-occiput-osseous-labyrinth-vasculature-and-neuroanatomy
#9
Ricardo Araújo, Vincent Fernandez, Michael J Polcyn, Jörg Fröbisch, Rui M S Martins
Synapsida, the clade including therapsids and thus also mammals, is one of the two major branches of amniotes. Organismal design, with modularity as a concept, offers insights into the evolution of therapsids, a group that experienced profound anatomical transformations throughout the past 270 Ma, eventually leading to the evolution of the mammalian bauplan. However, the anatomy of some therapsid groups remains obscure. Gorgonopsian braincase anatomy is poorly known and many anatomical aspects of the brain, cranial nerves, vasculature, and osseous labyrinth, remain unclear...
2017: PeerJ
https://www.readbyqxmd.com/read/28411885/characterization-of-a-novel-caudal-vertebral-interbody-fusion-in-a-rat-tail-model-an-implication-for-future-material-and-mechanical-testing
#10
Yu-Cheng Yeh, Cheng-Chun Yang, Ching-Lung Tai, Tsung-Ting Tsai, Po-Liang Lai, Tsai-Sheng Fu, Chi-Chien Niu, Lih-Huei Chen, Wen-Jer Chen
BACKGROUND: Of the proposed animal interbody fusion models, rat caudal discs have gained popularity in disc research due to their strong resemblance to human discs with respect to geometry, composition and mechanical properties. The purpose of this study is to demonstrate an efficient, repeatable and easily accessible animal model of interbody fusion for future research into mechanical testing and graft materials. METHODS: Twelve 12-week-old female Sprague-Dawley (SD) rats underwent caudal interbody fusion of the third and fourth coccygeal vertebrae of the tail...
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28409128/the-use-of-bone-morphogenetic-proteins-bmp-and-pseudarthrosis-a-literature-review
#11
REVIEW
Oberdan Ribeiro Gonçalves de Oliveira, Saul Pinheiro Rebouças Martins, Wyvison Gomes de Lima, Marília Maia Gomes
Bone morphogenetic proteins (BMP) are multi-functional growth factors to promote bone healing with the proposal of less morbidity compared to the usual methods of bone graft harvest. Pseudoarthrosis occur when the fusion attempt fails, a solid fusion is not achieved, or there is motion across the segment leading to it, and it can be clinically symptomatic as pain, deformity, neurocompression, or hardware failure. BMPs are used at spinal fusion as a tool for the treatment of degenerative, traumatic, neoplastic and infectious conditions of the spine...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28408261/use-of-intraoperative-navigation-for-reconstruction-of-the-c1-lateral-mass-after-resection-of-aneurysmal-bone-cyst
#12
Jennifer Neva, Brandon W Smith, Jacob R Joseph, Paul Park
BACKGROUND: Aneurysmal bone cysts (ABC) are rare blood-filled cystic lesions that are found in the long bones and spine. Here, we present a case of an ABC found in the lateral mass and lamina of C1. Lesions in this area provide a surgical challenge due to its difficulty in access as well as its need for reconstruction. We describe a novel use of intraoperative navigation (ION) to assist in the placement of a C1 lateral mass titanium cage. CASE DESCRIPTION: An 18-year-old female presented with headaches and progressive neck pain...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28408260/evaluation-of-bioabsorbable-multiamino-acid-copolymer-nano-hydroxyapatite-calcium-sulphate-cage-in-a-goat-spine-model
#13
Chunpeng Ren, Yueming Song, Youdi Xue, Xi Yang, Chunguang Zhou
BACKGROUND: Recently, polylactide is the most popular material used to made bioabsorbable cages, but too fast degradation and osteolysis around the cage have been reported in the literature. This study evaluated the fusion effect, biomechanical stability and histological characteristics of a novel bioabsorbable multi-amino acid copolymer/nano-hydroxyapatite/calcium sulphate (MAACP/n-HA/CS) interbody cage in a goat model of anterior cervical discectomy and fusion (ACDF). METHODS: A total of 24 goats underwent C3/C4 discectomy and fusion with three groups of intervertebral implants: MAACP/n-HA/CS cage group (n = 8), titanium cage group (n = 8) and autologous tricortical iliac crest bone group (n = 8)...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28407019/comparison-between-titanium-mesh-and-autogenous-iliac-bone-graft-to-restore-vertebral-height-through-posterior-approach-for-the-treatment-of-thoracic-and-lumbar-spinal-tuberculosis
#14
COMPARATIVE STUDY
Yongjian Gao, Yunsheng Ou, Qianxing Deng, Bin He, Xing Du, Jianxiao Li
OBJECT: To compare the clinical efficacy of titanium mesh cages and autogenous iliac bone graft to restore vertebral height through posterior approach in patients with thoracic and lumbar spinal tuberculosis. METHOD: 59 patients with spinal tuberculosis underwent interbody fusion and internal fixation through posterior approach in our department from January 2011 to December 2013. In group A, 34 patients obtained titanium mesh for the reconstruction of vertebral height, among them 25 patients (group A1) suffered from single-segment spinal tuberculosis, and 9 patients, (group A2) had multi-segment spinal tuberculosis...
2017: PloS One
https://www.readbyqxmd.com/read/28405613/rip140-in-monocytes-macrophages-regulates-osteoclast-differentiation-and-bone-homeostasis
#15
Bomi Lee, Urszula T Iwaniec, Russell T Turner, Yi-Wei Lin, Bart L Clarke, Anne Gingery, Li-Na Wei
Osteolytic bone diseases, such as osteoporosis, are characterized by diminished bone quality and increased fracture risk. The therapeutic challenge remains to maintain bone homeostasis with a balance between osteoclast-mediated resorption and osteoblast-mediated formation. Osteoclasts are formed by the fusion of monocyte/macrophage-derived precursors. Here we report, to our knowledge for the first time, that receptor-interacting protein 140 (RIP140) expression in osteoclast precursors and its protein regulation are crucial for osteoclast differentiation, activity, and coupled bone formation...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28403693/anterior-retropharyngeal-plate-screw-fixation-with-bilateral-anterior-transarticular-screws-for-odontoid-fractures-a-new-comprehensive-technique
#16
Sushil Patkar
INTRODUCTION: A certain group of odontoid fractures (Anderson and D' Alonzo Type-2) are usually offered surgical treatment. Common surgical option is an anterior odontoid screw. Some of the fractures are not suitable for anterior odontoid screw (anterior oblique, displaced distal fragments and those with atlantoaxial instability) and these are usually offered posterior transarticular screws (Magerl's) or posterior atlantoaxial screw rod/plate fixation (Goel-Harms technique). Posterior surgery involves atlantoaxial fixation with an indirect attempt to reduce and fuse the fracture ...
April 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28402086/the-effect-of-increased-microporosity-on-bone-formation-within-silicate-substituted-scaffolds-in-an-ovine-posterolateral-spinal-fusion-model
#17
Melanie Jean Coathup, Gordon William Blunn, Charlie Campion, Chih-Yuan Ho, Karin Angela Hing
This study compared the bone forming capacity of the same formulation of silicate-substituted bone graft substitute materials with different microporosity in an instrumented posterolateral spinal fusion ovine model. Materials with a strut porosity of (i) 22.5% (SiCaP) or (ii) 36.0% (SiCaP(+)) were packed along either side of the spine. Bone apposition rates, % new bone formation, % bone-implant contact, and % graft resorption were quantified at 8, 12, and 24 weeks post surgery. Computed Tomography (CT) was used to grade the formation of fusion bridges between vertebrae...
May 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28400871/results-of-arthroscopic-ankle-arthrodesis-with-fixation-using-two-parallel-headless-compression-screws-in-a-heterogenic-group-of-patients
#18
Lukas Kolodziej, Boguslaw Sadlik, Sebastian Sokolowski, Andrzej Bohatyrewicz
BACKGROUND: As orthopedic surgeons become skilled in ankle arthroscopy technique and evidence -based data is supporting its use, arthroscopic ankle arthrodesis (AAA) will likely continue to increase, but stabilization methods have not been described clearly. We present a technique for two parallel 7.3-mm headless compression screws fixation (HCSs) for AAA in cases of ankle arthritis with different etiology, both traumatic and non-traumatic, including neuromuscular and inflammatory patients...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28397554/sauv%C3%A3-kapandji-procedure-with-headless-compression-screw-in-patients-with-rheumatoid-arthritis
#19
Atsushi Maeda, Taku Suzuki, Masaki Hasegawa, Takashi Kuroiwa, Kanae Shizu, Katsuhiko Hayakawa, Takashi Tsuji, Katsuji Suzuki, Harumoto Yamada
OBJECTIVE: We examined the surgical outcomes of the Sauvé-Kapandji (S-K) procedure using a headless compression screw and a metal cancellous screw in patients with rheumatoid arthritis (RA). METHODS: This retrospective study included 41 RA patients who underwent the S-K procedure for distal radioulnar joint disorders with two screws: headless compression screws (HCS group, n = 20) and cannulated cancellous screws (CCS group, n = 21). Clinical and radiographic outcomes were assessed 1 year after surgery...
April 11, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28396901/-%C3%A2-biomechanics-of-new-implants-for-hto
#20
D Pape, A Diffo Kaze, A Hoffmann, S Maas
Biomechanical characteristics of 5 tibial osteotomy plates for the treatment of medial knee joint osteoarthritis were examined. Fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy, using TomoFix™ standard, PEEKPower®, ContourLock®, TomoFix™ small stature plates, and iBalance® implants. Static compression load to failure and load-controlled cyclic fatigue failure tests were performed. All plates had sufficient stability up to 2400 N in the static compression load to failure tests...
April 10, 2017: Der Orthopäde
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