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Bone Fusion

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https://www.readbyqxmd.com/read/29458048/4-phenylbutyric-acid-protects-against-lipopolysaccharide-induced-bone-loss-by-modulating-autophagy-in-osteoclasts
#1
Hyun-Jung Park, Ho-Jung Son, Ok-Joo Sul, Jae-Hee Suh, Hye-Seon Choi
4-Phenylbutyric acid (4-PBA) has been used clinically to treat urea cycle disorders and is known to be an inhibitor of endoplasmic reticulum (ER) stress. We hypothesized that 4-PBA attenuates inflammatory bone loss by inducing autophagy, a process that is frequently accompanied by ER stress. Micro computerized tomography analysis showed that 4-PBA attenuated LPS-induced bone loss in mice. The increased area of TRAP-positive osteoclasts (OCs) and serum level of collagen type I fragments in lipopolysaccharide (LPS)-treated mice were also decreased when 4-PBA was administered, suggesting a protective role of 4-PBA in OCs...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29457442/-development-and-application-of-artificial-vertebral-body
#2
REVIEW
Jian-Tao Liu, Feng Zhang, Zheng-Chao Gao, Bin-Bin Niu, Yu-Huan Li, Xi-Jing He
Artificial vertebral body has achieved good results in treating spinal tumors, tuberculosis, fracture and other diseases. Currently, artificial vertebral body with variety of kinds and pros and cons, is generally divided into two types: fusion type and movable type. The former according to whether the height could be adjusted and strength of self-stability is divided into three types: support-fixed type, adjust-fixed type and self-fixed type. Whether the height of self-fixed type could be adjusted is dependent on structure of collar thread rotation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29456339/retrospective-analysis-of-arthrodesis-from-various-options-after-anterior-cervical-discectomy
#3
Vinaysagar Sharma, Shashwat Kumar Singh
Introduction: Anterior cervical discectomy is a surgical procedure performed to treat a herniated/degenerated disc in the cervical region. There have been various studies comparing arthrodesis rates among various procedures. Our patients belonged to varied socioeconomic background and underwent anterior cervical microdiscectomy without/with instrumentation. Aim: The present study was performed to study and compare the arthrodesis rates in the patients operated for anterior cervical microdiscectomy with and without fusion/instrumentation procedures at our institution...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455479/-clinical-application-of-modified-inverted-l-shape-incision-by-extraperitoneal-approach-to-lumbosacral-tuberculosis
#4
Shi-Yuan Shi, Sheng-Ping Hu, Jun Fei, Zhen Lai, Gui-He Hang
OBJECTIVE: To explore the clinical effects of one-stage posterior transpedicular screw system internal fixation combined with anterior debridement and bone grafting with modified inverted L-shape incision by extraperitoneal approach in treating multiple lumbosacral tuberculosis. METHODS: The clinical data of 15 patients with multiple lumbosacral tuberculosis underwent operation from February 2008 to December 2014 were retrospectively analyzed. There were 9 males and 6 females with an average of (47...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455478/-comparision-of-clinical-effects-between-one-stage-anterior-and-posterior-approach-in-treating-thoracolumbar-tuberculosis-with-debridement-and-internal-fixation
#5
Bin Lin, Li-Lin Dai, Zhi-da Chen, Yong Zheng
OBJECTIVE: To compare the outcomes of surgical operation by posterior or anterior approach only for thoracolumbar tuberculosis. METHODS: The clinical data of 97 patients with thoracolumbar tuberculosis underwent debridement and internal fixation from January 2005 to December 2014 were retrospectively analyzed. The study included 59 males and 38 females, with a mean age of 53.7 years ranged from 20 to 68 years. The course of disease was from 1 to 13 months with an average of (6...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29454616/zoledronate-modulates-intracellular-vesicle-trafficking-in-mast-cells-via-disturbing-the-interaction-of-myosinva-rab3a-and-sytaxin4-vamp7
#6
Shuang Liu, Muhammad N A Sahid, Erika Takemasa, Kazutaka Maeyama, Masaki Mogi
Nitrogen-containing bisphosphonates (NBPs) have been widely used as bone anti-resorptive drugs for the treatment of osteoclast-dependent bone disorders. Zoledronate is currently the most potent NBP, and has potential as an inhibitor of farnesyl pyrophosphate synthase. The present study was undertaken to elucidate the possible effects of zoledronate on FcεRI-dependent mast cell activity in vitro, which is essential for in maintaining homeostasis of the gastrointestinal mucosa. Treatment with zoledronate significantly diminished exocytosis of mast cells, which was reflected by a decrease of FcεRI-dependent histamine release compared to that in vehicle-treated mast cells...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29453313/multigene-profiling-of-ctcs-in-mcrpc-identifies-a-clinically-relevant-prognostic-signature
#7
Udit Singhal, Yugang Wang, James Henderson, Yashar S Niknafs, Yuanyuan Qiao, Amy Gursky, Alexander Zaslavsky, Jae-Seung Chung, David C Smith, R Jeffrey Karnes, S Laura Chang, Felix Y Feng, Ganesh S Palapattu, Russell S Taichman, Arul M Chinnaiyan, Scott A Tomlins, Todd M Morgan
The trend towards precision-based therapeutic approaches dictated by molecular alterations offers substantial promise for men with metastatic castration resistant prostate cancer (mCRPC). However, current approaches for molecular characterization are primarily tissue based, necessitating serial biopsies to understand changes over time and are limited by the challenges inherent to extracting genomic material from predominantly bone metastases. Therefore, a circulating tumor cell (CTC)-based assay was developed to determine gene expression across a panel of clinically relevant and potentially actionable prostate cancer related genes...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29452282/load-sharing-through-elastic-micro-motion-accelerates-bone-formation-and-interbody-fusion
#8
Eric H Ledet, Glenn P Sanders, Darryl J DiRisio, Joseph C Glennon
BACKGROUND: Context: Achieving a successful spinal fusion requires the proper biologic and biomechanical environment. Optimizing load-sharing in the interbody space can enhance bone formation. For anterior cervical discectomy and fusion (ACDF), loading and motion are largely dictated by the stiffness of the plate which can facilitate a balance between stability and load-sharing. The advantages of load-sharing may be substantial for patients with comorbidities and in multi-level procedures where pseudarthrosis rates are significant...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29447753/kinematics-of-the-anthropoid-os-centrale-and-the-functional-consequences-of-scaphoid-centrale-fusion-in-african-apes-and-hominins
#9
Caley M Orr
In most primates, the os centrale is interposed between the scaphoid, trapezoid, trapezium, and head of the capitate, thus constituting a component of the wrist's midcarpal complex. Scaphoid-centrale fusion is among the clearest morphological synapomorphies of African apes and hominins. Although it might facilitate knuckle-walking by increasing the rigidity and stability of the radial side of the wrist, the exact functional significance of scaphoid-centrale fusion is unclear. If fusion acts to produce a more rigid radial wrist that stabilizes the hand and limits shearing stresses, then in taxa with a free centrale, it should anchor ligaments that check extension and radial deviation, but exhibit motion independent of the scaphoid...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29447305/pseudo-pedicle-heterotopic-ossification-from-use-of-recombinant-human-bone-morphogenetic-protein-2-rhbmp-2-in-transforaminal-lumbar-interbody-fusion-cages
#10
Charles D Rosen, P Douglas Kiester, Thay Q Lee
We conducted a study to determine the common characteristics of patients who developed radiculopathy symptoms and corresponding heterotopic ossification (HO) from transforaminal lumbar interbody fusions (TLIF) using recombinant human bone morphogenetic protein 2 (rhBMP-2). HO can arise from a disk space with rhBMP-2 use in TLIF. Formation of bone around nerve roots or the thecal sac can cause a radiculopathy with a consistent pattern of symptoms. We identified 38 patients (26 males, 12 females) with a mean (SD) age of 50...
January 2018: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29446010/phosphaturic-mesenchymal-tumors-what-an-endocrinologist-should-know
#11
REVIEW
J M Boland, P J Tebben, A L Folpe
Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. The vast majority of cases of TIO result from production of the phosphaturic hormone fibroblast growth factor 23 (FGF23) by a histologically distinctive mesenchymal tumor, termed "phosphaturic mesenchymal tumor" (PMT)...
February 14, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29445947/bone-graft-materials-for-posterolateral-fusion-made-simple-a-systematic-review
#12
REVIEW
Matthew T Morris, Sandip P Tarpada, Woojin Cho
BACKGROUND: Iliac crest has long been the gold standard for lumbar fusion, but concerns over donor site morbidity have led to a wide variety of bone graft substitutes. Despite prolific research, a general consensus is yet to be reached on bone graft materials that lead to optimal fusion. PURPOSE: The purpose of this review is to evaluate the current literature for bone graft material options that maximize fusion rate in posterolateral lumbar fusion surgery. DESIGN: Systematic Review...
February 14, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29443791/direction-changeable-lumbar-cage-versus-traditional-lumbar-cage-for-treating-lumbar-spondylolisthesis-a-retrospective-study
#13
Haiping Zhang, Yonghong Jiang, Biao Wang, Qinpeng Zhao, Simin He, Dingjun Hao
Despite the diverse designs for the lumbar interbody fusion cage, there is no consensus on the optimal design to date. The current study aimed to compare the efficacy and complications associated with the direction-changeable and traditional lumbar cages for treating lumbar spondylolisthesis.We conducted a retrospective study including 109 patients with lumbar spondylolisthesis, who were admitted to our hospital from January 2013 to December 2014. The patients were divided into the direction-changeable (group A) and traditional (group B) lumbar cage group...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29439670/phase-i-study-of-an-active-immunotherapy-for-asymptomatic-phase-lymphoplasmacytic-lymphoma-with-dna-vaccines-encoding-antigen-chemokine-fusion-study-protocol
#14
Sheeba K Thomas, Soung-Chul Cha, D Lynne Smith, Kun Hwa Kim, Sapna R Parshottam, Sheetal Rao, Michael Popescu, Vincent Y Lee, Sattva S Neelapu, Larry W Kwak
BACKGROUND: There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune system is involved in the therapeutic effect of these agents; this finding strongly supports the use of cancer vaccine strategies. Lymphoplasmacytic lymphoma (LPL) is a low grade, incurable disease featuring an abnormal proliferation of Immunoglobulin (Ig)-producing malignant cells...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29438218/full-endoscopic-uniportal-odontoidectomy-and-decompression-of-the-anterior-cervicomedullary-junction-using-the-retropharyngeal-approach
#15
Sebastian Ruetten, Patrick Hahn, Semih Oezdemir, Xenophon Baraliakos, Harry Merk, Georgios Godolias, Martin Komp
STUDY DESIGN: A study of a series of consecutive full-endoscopic uniportal decompressions of the anterior craniocervical junction with retropharyngeal approach. OBJECTIVE: The aim of this study was to evaluate the direct anterior decompression of the craniocervical junction in patients with bulbomedullary compression using a full-endoscopic uniportal technique via an anterolateral retropharyngeal approach. SUMMARY OF BACKGROUND DATA: Acute or progressive myelopathy may necessitate direct anterior decompression of the craniocervical junction and odontoidectomy...
February 12, 2018: Spine
https://www.readbyqxmd.com/read/29435292/a-novel-three-way-philadelphia-variant-t-9-22-17-q34-q11-2-q12-in-chronic-myeloid-leukemia-a-case-report
#16
Kathy Allen-Proctor, Elizabeth Ruckdeschel, Rana Naous
Chronic myeloid leukemia (CML) is a hematologic malignancy associated with increased circulating myeloid cells and platelets in the peripheral blood, with accompanying bone marrow hyperplasia. The Philadelphia chromosome, t(9;22)(q34;q11), is present in 95% of CML patients, resulting in constitutive tyrosine kinase activity; however, ~5% of CML patients possess a Philadelphia variant. A novel three-way Philadelphia translocation variant, t(9;22;17)(q34;q11.2;q11.2), was identified in a 54-year old man who presented with leukocytosis, anemia and thrombocytosis that was diagnosed with chronic myeloid leukemia, chronic phase...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29433006/strains-in-trussed-spine-interbody-fusion-implants-are-modulated-by-load-and-design
#17
Jason P Caffrey, Eloy Alonso, Koichi Masuda, Jessee P Hunt, Cameron N Carmody, Timothy M Ganey, Robert L Sah
Titanium cages with 3-D printed trussed open-space architectures may provide an opportunity to deliver targeted mechanical behavior in spine interbody fusion devices. The ability to control mechanical strain, at levels known to stimulate an osteogenic response, to the fusion site could lead to development of optimized therapeutic implants that improve clinical outcomes. In this study, cages of varying design (1.00 mm or 0.75 mm diameter struts) were mechanically characterized and compared for multiple compressive load magnitudes in order to determine what impact certain design variables had on localized strain...
February 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29431183/transcriptomic-definition-of-molecular-subgroups-of-small-round-cell-sarcomas
#18
Sarah Watson, Virginie Perrin, Delphine Guillemot, Stephanie Reynaud, Jean-Michel Coindre, Marie Karanian, Jean-Marc Guinebretière, Paul Freneaux, François Le Loarer, Megane Bouvet, Louise Galmiche-Rolland, Frédérique Larousserie, Elisabeth Longchampt, Dominique Ranchere-Vince, Gaelle Pierron, Olivier Delattre, Franck Tirode
Sarcoma represents a highly heterogeneous group of tumours. We report here the first unbiased and systematic search for gene fusions combined with unsupervised expression analysis of a series of 184 small round cell sarcomas. Fusion genes were detected in 59% percent of samples, with half of them being observed recurrently. We identified biologically homogeneous groups of tumours such as the CIC-fused (to DUX4, FOXO4 or NUTM1) and BCOR-rearranged (BCOR-CCNB3, BCOR-MAML3, ZC3H7B-BCOR and BCOR internal duplication) tumour groups...
February 12, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29430603/a-comparative-study-of-single-stage-transpedicular-debridement-fusion-and-posterior-long-segment-versus-short-segment-fixation-for-the-treatment-of-thoracolumbar-spinal-tuberculosis-in-adults-minimum-five%C3%A2-year-follow-up-outcomes
#19
Zheng Liu, Penghui Zhang, Hao Zeng, Zhengquan Xu, Xiyang Wang
DESIGN: This a retrospective study in single centre. OBJECTIVE: The objective of this retrospective clinical study is to compare the long-term clinical efficacy of posterior long-segment and short-segment fixation with single-stage transpedicular debridement and fusion for the treatment of thoracolumbar spinal tuberculosis in adults. METHODS: Sixty-six cases of thoracolumbar tuberculosis were treated by single-stage transpedicular debridement, bone graft fusion, and pedicle screw fixation...
February 11, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29430266/minimally-invasive-sacroiliac-joint-fusion-2-year-radiographic-and-clinical-outcomes-with-a-principles-based-sij-fusion-system
#20
William W Cross, Arnold Delbridge, Donald Hales, Louis C Fielding
Background: Sacroiliac joint (SIJ) degeneration is a common source of low back pain (LBP). Minimally invasive (MI) SIJ fusion procedures have demonstrated meaningful clinical improvement. A recently developed MI SIJ fusion system incorporates decortication, placement of bone graft and fixation with threaded implants (DC/BG/TF). Patients and Methods: Nineteen patients who had MI SIJ fusion with DC/BG/TF were enrolled at three centers. Fusion was assessed in CT images obtained 12 and 24 months postoperatively by an independent radiographic core laboratory...
2018: Open Orthopaedics Journal
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