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Bone Fusion

Philip Huang, Mary Elizabeth Lundgren, Rajeev Garapati
Complete talar extrusion is rare and usually associated with a high-energy mechanism of injury causing complete dissociation of the talus from the surrounding bony and soft-tissue structures with enough force to expel the talus out of the body. Treatment can be complicated by infection, osteonecrosis, posttraumatic osteoarthritis, and leg length discrepancy, which may require multiple subsequent surgeries for improved outcome and quality of life. Reimplantation of the native talus affords maintenance of joint height and favorable outcomes have been reported...
June 21, 2018: Journal of the American Academy of Orthopaedic Surgeons
Eiichi Murakami, Daisuke Kurosawa, Toshimi Aizawa
OBJECTIVE The authors evaluated the outcomes of sacroiliac joint (SIJ) arthrodesis via an original anterior approach to the upper anterior surface of the SIJ in patients with a minimum of 5 years' follow-up. METHODS The authors performed anterior SIJ arthrodesis in 45 patients between 2001 and 2015. Of these patients, 27 (11 men and 16 women; mean age at surgery 49 [24-86] years) were followed up for a minimum of 5 years (average 113 months, range 61-157 months). In the 14 patients in the earlier period of this study, the authors used an anterior approach to expose the SIJ by separating the iliac muscle from the iliac bone and performed internal fixation...
June 22, 2018: Journal of Neurosurgery. Spine
Nishant Kumar, Ravish Shammi Patel, Mark Kim Thye Thong, Naresh Kumar
Ossification of the anterior longitudinal ligament (OALL) in cervical spine is known to cause dysphagia. However, dyspnoea and obstructive sleep apnoea (OSA) due to OALL is a rare entity. A 50-year-old man presented to our clinic 2 years after anterior cervical discectomy and fusion (ACDF) with complaints of dysphagia, dyspnoea and difficulty in sleeping supine. The clinico-neurological examination of patient was normal without any long tract signs. The diagnosis of OALL was made on plain lateral radiographs...
June 20, 2018: BMJ Case Reports
Alla Bezhentseva, Harpreet Singh, Randy J Boudrieau
OBJECTIVE:  This article describes corrective antebrachiocarpal re-alignment and arthrodesis for bilateral radial hemimelia (radial agenesis) in an 8-month-old domestic short-haired cat. METHODS:  Bilateral forelimb deformity of ulnocarpal varus with complete luxation and rotation of the antebrachiocarpal joint spaces, and joint contracture, was observed. Several carpal bones and metacarpal bones I and II and their associated phalanges were absent. Abnormal ambulation and weight bearing on the dorsolateral part of the manus were present...
June 20, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Joshua Shubert, Muyinatu A Lediju Bell
It is well known that there are structural differences between cortical and cancellous bone. However, spinal surgeons currently have no reliable method to non-invasively determine these differences in real-time when choosing the optimal starting point and trajectory to insert pedicle screws and avoid surgical complications associated with breached or weakened bone. This paper explores 3D photoacoustic imaging of a human vertebra to noninvasively differentiate cortical from cancellous bone for this surgical task...
June 20, 2018: Physics in Medicine and Biology
Tomoo Osumi, Shin-Ichi Tsujimoto, Moe Tamura, Meri Uchiyama, Kazuhiko Nakabayashi, Kohji Okamura, Masanori Yoshida, Daisuke Tomizawa, Akihiro Watanabe, Hiroyuki Takahashi, Tsukasa Hori, Shohei Yamamoto, Kazuko Hamamoto, Masahiro Migita, Hiroko Ogata-Kawata, Toru Uchiyama, Hiroe Kizawa, Hitomi Ueno-Yokohata, Ryota Shirai, Masafumi Seki, Kentaro Ohki, Junko Takita, Takeshi Inukai, Seishi Ogawa, Toshio Kitamura, Kimikazu Matsumoto, Kenichiro Hata, Nobutaka KIyokawa, Susumu Goyama, Motohiro Kato
Translocations of retinoic acid receptor-α (RARA), typically PML-RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without RARA translocation to elucidate the molecular etiology of RARA-negative APL. We performed whole-genome sequencing, PCR, and FISH for five APL cases without RARA translocations. Four of five RARA-negative APL cases had translocations involving retinoic acid receptor-β (RARB) translocations, and TBL1XR1-RARB was identified as an in-frame fusion in three cases; one case had an RARB rearrangement detected by FISH, although the partner gene could not be identified...
June 19, 2018: Cancer Research
Shunichi Toki, Susumu Wakai, Masaya Sekimizu, Taisuke Mori, Hitoshi Ichikawa, Akira Kawai, Akihiko Yoshida
AIMS: Ewing sarcoma is a small round cell tumor that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was consistently expressed in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. Here, we evaluated the utility of PAX7 immunohistochemistry in whole-tissue sections of an expanded array of round cell malignancies with adequate molecular characterization...
June 19, 2018: Histopathology
Ju-Wan Seuk, Junseok Bae, Sang-Ho Lee, Sang-Ha Shin, Ho Jin Kim
BACKGROUND: Even with its growing popularity, there weren't any comparative studies that explored MCID of HRQoLs following LIF performed on a single-level adult LGIS. OBJECTIVE: The purpose of this study is to investigate factors related to MCID of HRQoLs following instrumented LIF performed on a single-level adult LGIS. METHODS: Consecutive patients who underwent instrumented LIF for single-level LGIS were reviewed. The inclusion criteria were : adult patients who underwent L4-5 or L5-S1, ALIF or TLIF with a posterior screw fixation, and had a minimum 36-month post-operative follow-up period...
June 16, 2018: World Neurosurgery
Naoki Notani, Masashi Miyazaki, Masahiro Toyoda, Shozo Kanezaki, Toshinobu Ishihara, Hiroshi Tsumura
Exfoliated carbon nanofibers (ExCNFs) are expected to serve as excellent scaffolds for promoting and guiding bone-tissue regeneration. We aimed to enhance the effects of ExCNFs using bone morphogenetic proteins (BMPs) and examined their feasibility and safety in clinical applications using a rat spinal fusion model. Group I (n = 15) animals were implanted with the control carrier; Group II (n = 16) animals were implanted with carrier containing 1 μg ExCNFs; Group III (n = 16) animals were implanted with carrier containing 1 μg recombinant human (rh) BMP-2; and Group IV (n = 17) animals were implanted with carrier containing 1 μg rhBMP-2 and 1 μg ExCNFs...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Alain Borgeat, Christian Ofner, Andrea Saporito, Mazda Farshad, José Aguirre
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in postoperative pain management. While an increasing number of in vitro and animal studies point toward an inhibitory effect of NSAIDs on bone healing process, the few existing retro- and prospective clinical studies present conflicting data. DESIGN: The aim of this qualitative, systematic review was to investigate the impact of perioperative use of NSAIDs in humans on postoperative fracture/spinal fusion healing compared to other used analgesics measured as fracture nonunion with radiological control...
June 15, 2018: Journal of Clinical Anesthesia
Kirk Geale, María Álvarez, Maria Polyzoi, Xavier Màlaga, Cristina Pineda, César Hernández
OBJECTIVE: Estimate the budget impact (BI) of introducing local autograft (LA) combined with demineralized bone matrix (LA+DBM) in lumbar spinal fusion (LSF) procedures to treat lumbar degenerative disc disease (LDDD) in Spain. METHODS: A decision tree model was developed to evaluate the 4-year BI associated with introducing LA+DBM putty to replace currently available grafting methods including iliac crest bone graft (ICBG), LA alone, and LA combined with beta-tricalcium phosphate (LA+ceramics), with 30%, 40%, and 30% market shares, respectively...
June 18, 2018: Journal of Medical Economics
Tanja Niedermair, Stephan Schirner, Raphael Seebröker, Rainer H Straub, Susanne Grässel
Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies we observed impaired biomechanical and structural bone parameters in tachykinin (Tac) 1-deficient mice lacking SP. Here, we aim to specify effects of SP on metabolic parameters of bone marrow macrophage (BMM)/osteoclast cultures and osteoblasts isolated from Tac1-deficient and wildtype (WT) mice. We demonstrated endogenous SP production and secretion in WT bone cells...
June 15, 2018: Scientific Reports
Andrea Calvo-Echenique, José Cegoñino, Raúl Chueca, Amaya Pérez-Del Palomar
BACKGROUND AND OBJECTIVE: Spinal degeneration and instability are commonly treated with interbody fusion cages either alone or supplemented with posterior instrumentation with the aim to immobilise the segment and restore intervertebral height. The purpose of this work is to establish a tool which may help to understand the effects of intervertebral cage design and placement on the biomechanical response of a patient-specific model to help reducing post-surgical complications such as subsidence and segment instability...
August 2018: Computer Methods and Programs in Biomedicine
Luciano Mastronardi, Raffaelino Roperto, Guglielmo Cacciotti, Francesco Calvosa
BACKGROUND:  Anterior cervical fusion (ACF) with autologous bone was reported > 50 years ago. The continuous development of materials with elastic properties close to that of the cortical bone improves induction of osteogenesis and simplifies the technique of interbody fusion. To determine the safety and efficiency of stand-alone trabecular metal (TM) (or porous tantalum) cages for ACF, we performed a retrospective analysis of 88 consecutive patients with one-level or two-level degenerative disk disease (DDD) causing cervical myelopathy treated by interbody fusion with stand-alone TM cages...
June 14, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Gabriel Fernandez de Grado, Laetitia Keller, Ysia Idoux-Gillet, Quentin Wagner, Anne-Marie Musset, Nadia Benkirane-Jessel, Fabien Bornert, Damien Offner
Bone replacement might have been practiced for centuries with various materials of natural origin, but had rarely met success until the late 19th century. Nowadays, many different bone substitutes can be used. They can be either derived from biological products such as demineralized bone matrix, platelet-rich plasma, hydroxyapatite, adjunction of growth factors (like bone morphogenetic protein) or synthetic such as calcium sulfate, tri-calcium phosphate ceramics, bioactive glasses, or polymer-based substitutes...
January 2018: Journal of Tissue Engineering
Faqi Wang, Lin Wang, Yafei Feng, Xiaojiang Yang, Zhensheng Ma, Lei Shi, Xiangyu Ma, Jian Wang, Tiancheng Ma, Zhao Yang, Xinxin Wen, Yang Zhang, Wei Lei
Tantalum (Ta)-coated porous Ti-6A1-4V scaffolds have better bioactivity than Ti-6A1-4V scaffolds; however, their bioperformance as an artificial vertebral body (AVB) is unknown. In the present study, we combined a Ta-coated Ti-6A1-4V scaffold with rabbit bone marrow stromal cells (BMSCs) for tissue-engineered AVB (TEAVB) construction and evaluated the healing and fusion efficacy of this scaffold in lumbar vertebral defects after corpectomy in rabbits. The results showed that BMSCs on the surface of the Ta-coated Ti scaffolds proliferated better than BMSCs on Ti scaffolds...
June 12, 2018: Scientific Reports
Hadeel Halalsheh, Mary Beth McCarville, Michael Neel, Mark Reynolds, Michael C Cox, Alberto S Pappo
Mesoblastic nephroma is the most frequent renal tumor in newborns and young infants, and the cellular type is characterized by an ETV6-NTRK fusion, which constitutively activates the tropomyosin-related kinase (TRK) signaling pathway. Larotrectinib is a highly selective TRK inhibitor with activity in adult and pediatric patients who have TRK fusions. We present a rare case of a patient with mesoblastic nephroma metastatic to bone who had a dramatic response to larotrectinib.
June 12, 2018: Pediatric Blood & Cancer
Manoj Kumar Panigrahi, Gourahari Pradhan, Nibedita Sahoo, Pritinanda Mishra, Susama Patra, Prasanta Raghab Mohapatra
Synovial sarcoma (SS) is a malignant mesenchymal tumor with variable epithelial differentiation that affects mostly young adults and can arise at any anatomic site. Primary intrathoracic SS is very rare accounting for <0.5% of all lung tumors. Most commonly, it arises from the lung followed by pleura and mediastinum. Primary pulmonary SS (PPSS) affects both sexes equally with no preference for any hemithorax. The morphology, immunostaining properties, cytogenetic features, and management strategy of PPSS are similar to that of soft tissue SS...
April 2018: Journal of Cancer Research and Therapeutics
Feng Zhang, Jian-Tao Liu, Rui Wang, Teng Lu, Bin-Bin Niu, Jie Qie, Xuan Cai, Ting Zhang, Peng-Rong Ouyang, Xi-Jing He
OBJECTIVE: To explore the feasibility and the attention of perioperative management of goat lumbar fusion model for individualized 3D printing technology. METHODS: According to preoperative X-ray and CT three dimensional reconstruction data of 10 males Boer goat's lumbar(1-2 years old, weight 35-45 kg), the preoperative open height were determined, meanwhile, according to the theoretical entry point of nails, the length of steel plate, arc, and setting position, screw length for reference were determined, the lumbar lateral anterior plate was designed and 3D-printed...
May 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Pravin Salunke, Madhivanan Karthigeyan, Sushanta K Sahoo, Narasimhaiah Sunil
OBJECTIVE: Congenital atlanto-axial dislocation (CAAD) often manifests in younger age group. Softer bones, deformed joints and the concern of fusing multiple segments in growing age set apart this subset of patients from adults. Objectives of this manuscript are to discuss the challenges faced and subsequent solutions during multiplanar realignment and fusion (short segment) of C1-2 joints through a direct posterior approach in pediatric CAAD. PATIENTS & METHODS: 56 pediatric patients with CAAD were operated through a direct posterior approach in the last 4 years...
June 5, 2018: Clinical Neurology and Neurosurgery
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