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Bone Fusion

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https://www.readbyqxmd.com/read/29227787/major-destructive-asymptomatic-lumbar-charcot-lesion-treated-with-three-column-resection-and-short-segment-reconstruction-case-report-treatment-strategy-and-review-of-literature
#1
Kestutis Valancius, Gaurav Garg, Madalina Duicu, Ebbe Stender Hansen, Cody Bunger
Charcot's spine is a long-term complication of spinal cord injury. The lesion is often localized at the caudal end of long fusion constructs and distal to the level of paraplegia. However, cases are rare and the literature relevant to the management of Charcot's arthropathy is limited. This paper reviews the clinical features, diagnosis, and surgical management of post-traumatic spinal neuroarthropathy in the current literature. We present a rare case of adjacent level Charcot's lesion of the lumbar spine in a paraplegic patient, primarily treated for traumatic spinal cord lesion 39 years before current surgery...
2017: SICOT-J
https://www.readbyqxmd.com/read/29226717/atypical-chronic-myeloid-leukemia-a-rare-entity-with-management-challenges
#2
Prajwal Dhakal, Krishna Gundabolu, Catalina Amador, Supratik Rayamajhi, Vijaya Raj Bhatt
The aim of our study was to review the clinicopathologic features and management of atypical chronic myeloid leukemia (aCML). Relevant manuscripts published in English were searched using PubMed. aCML is diagnosed as per WHO 2016 classification in the presence of leukocytosis ≥13 × 109/l with circulating neutrophil precursors ≥10%, monocytes less than 10%, minimal basophils, hypercellular bone marrow with granulocytic proliferation and dysplasia, bone marrow blast less than 20% and absence of BCR/ABL fusion gene...
December 11, 2017: Future Oncology
https://www.readbyqxmd.com/read/29226197/osteoporosis-and-the-management-of-spinal-degenerative-disease-i
#3
REVIEW
Félix Tomé-Bermejo, Angel R Piñera, Luis Alvarez-Galovich
Osteoporosis has become a major medical problem as the aged population of the world rapidly grows. Osteoporosis predisposes patients to fracture, progressive spinal deformities, and stenosis, and is subject to be a major concern before performing spine surgery, especially with bone fusions and instrumentation. Osteoporosis has often been considered a contraindication for spinal surgery, while in some instances patients have undergone limited and inadequate procedures in order to avoid concomitant instrumentation...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29225416/getting-peek-to-stick-to-bone-the-development-of-porous-peek-for-interbody-fusion-devices
#4
F Brennan Torstrick, David L Safranski, J Kenneth Burkus, James L Chappuis, Christopher S D Lee, Robert E Guldberg, Ken Gall, Kathryn E Smith
Interbody fusion cages are routinely implanted during spinal fusion procedures to facilitate arthrodesis of a degenerated or unstable vertebral segment. Current cages are most commonly made from polyether-ether-ketone (PEEK) due to its favorable mechanical properties and imaging characteristics. However, the smooth surface of current PEEK cages may limit implant osseointegration and may inhibit successful fusion. We present the development and clinical application of the first commercially available porous PEEK fusion cage (COHERE®, Vertera, Inc...
September 2017: Techniques in Orthopaedics: TIO
https://www.readbyqxmd.com/read/29225115/thoracic-disc-herniation-surgical-treatment
#5
REVIEW
C Court, E Mansour, C Bouthors
Thoracic disc herniation is rare and mainly occurs between T8 and L1. The herniation is calcified in 40% of cases and is labelled as giant when it occupies more than 40% of the spinal canal.A surgical procedure is indicated when the patient has severe back pain, stubborn intercostal neuralgia or neurological deficits. Selection of the surgical approach is essential. Midline calcified hernias are approached from a transthoracic incision, while lateralized soft hernias can be approached from a posterolateral incision...
December 7, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29223526/spontaneous-spinal-arthordesis-in-stand-alone-percutaneous-pedicle-screw-fixation-without-in-situ-fusion-in-patients-with-lumbar-segmental-instability-long-term-clinical-radiologic-and-functional-outcome
#6
Roberto Gazzeri, Kostantinos Panagiotopoulos, Santino Princiotto, Umberto Agrillo
BACKGROUND: No study to date has established how commonly spontaneous fusion occurs after stand-alone percutaneous pedicle screw fixation in adult population. OBJECTIVE: In this retrospective single center study, the authors investigated the effectiveness, long-term solidity and safety of stand-alone percutaneous pedicle screw fixation without in situ fusion and the influence of presence or absence of fusion on the clinical outcome of patients with low-grade lumbar segmental instability...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29222837/low-melt-bioactive-glass-reinforced-3d-printing-akermanite-porous-cages-with-highly-improved-mechanical-properties-for-lumbar-spinal-fusion
#7
Xiurong Ke, Lei Zhang, Xianyan Yang, Juncheng Wang, Chen Zhuang, Zhouwen Jin, An Liu, Tengfei Zhao, Sanzhong Xu, Changyou Gao, Zhongru Gou, Guojing Yang
Although great strides have been made in medical technology, low back/neck pain and intervertebral disc degeneration initiated from disc degenerative disease remains a clinical challenge. Within the field of regenerative medicine therapy, we have sought to improve the biomechanical transformation of spinal fusion procedures conducted using biodegradable porous implants. Specifically, we have focused on developing mechanically strong bioceramic cages for spinal fusion and functional recovery. Herein we fabricated the akermanite (AKE) ceramic-based porous cages using low-melting bioactive glass (BG) and 3D printing technology...
December 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29221343/adult-onset-langerhans-cell-histiocytosis-of-the-sternum
#8
Yi-Jhih Huang, Kuan-Hsun Lin, Tai-Kuang Chao, Tsai-Wang Huang, Hsu-Kai Huang
Langerhans cell histiocytosis (LCH) is a rare disease with uncertain etiology that is more prevalent in children. LCH typically invades skeletal systems, but in rare cases, it has been reported in the ribs or sternum. Optimal treatment choices for single-site, skeletal LCH are still undefined. We report a case of adult-onset LCH of the sternum. The range of surrounding soft tissue invasion was confirmed by three-dimensional fusion and reconstruction of chest computed tomography and magnetic resonance images...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29216691/lumbar-fusion-with-collagen-type-i-and-polyvinylpyrrolidone-in-combination-with-autograft-an-experimental-study-in-new-zealand-rabbits
#9
A Reyes-Sánchez, F Reyes-Tarrago, C García-Ramos, B Zárate-Kalfópulos, E Estrada-Villaseñor, A Alpizar-Aguirre
INTRODUCTION: Multiple strategies have been developed looking for upgrading the consolidation rate of spine arthrodesis with autolog bone graft, but no evidence exists that adhesion with Collagen type 1 and polyvinylpyrrolidone (FibroquelMR) have application on this field. OBJECTIVE: Determine if collagen type 1 + Polyvinylpyrrolidone are effective as bone enhancer in posterolateral arthrodesis on rabbits. METHOD: Posterolateral arthrodesis in 15 New Zealand rabbits on level L5-L6 using autolog bone graft in left side (control group) and autolog bone graft + 1 ml FibroquelMR (study group) in right side of arthrodesis...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29216265/oct4-expression-mediates-partial-cardiomyocyte-reprogramming-of-mesenchymal-stromal-cells
#10
Gustavo Yannarelli, Natalia Pacienza, Sonia Montanari, Diego Santa-Cruz, Sowmya Viswanathan, Armand Keating
Mesenchymal stem/stromal cells (MSCs) are in numerous cell therapy clinical trials, including for injured myocardium. Acquisition of cardiomyocyte characteristics by MSCs may improve cardiac regeneration but the mechanisms regulating this process are unclear. Here, we investigated whether the pluripotency transcription factor OCT4 is involved in the activation of cardiac lineage genetic programs in MSCs. We employed our established co-culture model of MSCs with rat embryonic cardiomyocytes showing co-expression of cardiac markers on MSCs independent of cell fusion...
2017: PloS One
https://www.readbyqxmd.com/read/29214757/clinical-and-cytogenetic-profiles-of-rhabdomyosarcoma-with-bone-marrow-involvement-in-korean-children-a-15-year-single-institution-experience
#11
Dong Hyun Lee, Chan Jeoung Park, Seongsoo Jang, Young Uk Cho, Jong Jin Seo, Ho Joon Im, Kyung Nam Koh, Kyung Ja Cho, Joon Seon Song, Eul Ju Seo
BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Alveolar RMS (ARMS) is characterized by FOXO1-related chromosomal translocations that result in a poorer clinical outcome compared with embryonal RMS (ERMS). Because the chromosomal features of RMS have not been comprehensively defined, we analyzed the clinical and laboratory data of childhood RMS patients and determined the clinical significance of chromosomal abnormalities in the bone marrow. METHODS: Fifty-one Korean patients with RMS <18 years of age treated between 2001 and 2015 were enrolled in this study...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29213014/a-case-of-a-giant-mass-in-the-lumbar-region-of-a-newborn-calf
#12
Kazuki Yoshioka, Aika Ishikawa, Makoto Sugiyama, Jun Nagasao, Motohiro Kikuchi
The present report describes a newborn calf with spina bifida that presented with a giant mass of the lumbar region, as well as subsequent gross, histological, and immunohistochemical examinations. A malformed Japanese black calf (estimated weight = 20 kg) was euthanized immediately after birth. A gross evaluation revealed a giant mass (approximately 60 cm × 30 cm × 15 cm) covered by the hair coat in the lumbar region and connected with the hair coat of the trunk. The mass surface was divided by a deep polygonal groove and externally resembled a lobulated kidney...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/29209025/oblique-corpectomy-in-the-cervical-spine
#13
Tomasz Tykocki, Łukasz A Poniatowski, Marcin Czyz, Guy Wynne-Jones
STUDY DESIGN: A narrative review. OBJECTIVES: A literature review of studies reporting on the application of oblique corpectomy (OC) in various pathologies of the cervical spine. SETTING: UK. METHODS: A search was carried out using the PubMed and Google Scholar up to 18 March 2017. Finally, 26 studies met the inclusion criteria. RESULTS: A multilevel OC shows good clinical outcomes in various pathologies in the cervical spine...
December 5, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29208475/cortical-bone-trajectory-screws-fixation-in-lumbar-adjacent-segment-disease-a-technique-note-with-case-series
#14
Chao-Hsuan Chen, Hsieng-Ming Huang, Der-Cherng Chen, Chih-Ying Wu, Han-Chun Lee, Der-Yang Cho
Lumbar adjacent segment disease after lumbar fusion surgery often requires surgical intervention. However, subsequent surgical treatment often needs to expose and remove all of the previous instruments. This additional surgery leads to significant post-operative pain, muscular fibrosis, poor wound healing and infection, etc. From October 2015 to March 2016, we collected six cases underwent cortical bone trajectory screws fixation with minimal invasive inter-body cage fusion for lumbar adjacent segment disease...
December 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29208449/surgical-treatment-of-thoracic-spinal-tuberculosis-a-multi-center-retrospective-study
#15
Wenjie Wu, Jingtong Lyu, Xun Liu, Fei Luo, TianYong Hou, Qiang Zhou, Zhilin Li, Yuan Chen, Li Tao Li, Yonghong Zheng, Gaoju Wang, Jianzhong Xu, Zehua Zhang
OBJECTIVE: The aim present multicenter retrospective study is to assess safety and effectiveness of different surgery strategy in thoracic tuberculosis, and to provide a reference for surgical treatment of thoracic tuberculosis. MATERIALS AND METHODS: This study reviewed 394 patients with thoracic tuberculosis who were treated in six institution between January 2000 and January 2015. There were 208 males and 186 females with average ages of 34.92±13.14 years (range 5-76 years)...
December 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29204196/delineate-yet-not-dread-anomalous-vertebral-artery-in-pediatric-congenital-atlantoaxial-dislocation-and-basilar-invagination
#16
Pravin Salunke
Introduction: The deformed joints seen in congenital atlantoaxial dislocation (CAAD) are often associated with vascular anomalies. It is important to identify these vascular anomalies and address them appropriately without compromising the manipulation and fusion of C1-C2 joints. The small bones in pediatric age group pose an additional challenge. Materials and Methods: Data of fifty-six children with CAAD operated in the last 4 years was analyzed. A computed tomography angiogram was obtained preoperatively to assess for the course of the third segment of vertebral artery (VA)...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29202743/posterior-intervertebral-space-debridement-annular-bone-grafting-and-instrumentation-for-treatment-of-lumbosacral-tuberculosis
#17
Weiwei Li, Jun Liu, Liqun Gong, Yongchun Zhou, Dapeng Duan
BACKGROUND: The choice of surgical methods for lumbosacral tuberculosis is controversial due to the complex anterior anatomy and peculiar biomechanics of the lumbosacral junction. The objective of this study was to explore the clinical effect of posterior intervertebral space debridement with annular bone graft fusion and fixation for the treatment of lumbosacral tuberculosis. METHODS: We retrospectively analysed data from 23 patients with lumbosacral tuberculosis who had undergone posterior intervertebral space debridement with annular bone fusion and fixation between January 2008 and September 2014...
December 4, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29202462/paracrine-osteoprotegerin-and-%C3%AE-catenin-stabilization-support-synovial-sarcomagenesis-in-periosteal-cells
#18
Jared J Barrott, Benjamin E Illum, Huifeng Jin, Matthew L Hedberg, Yanliang Wang, Allie Grossmann, Malay Haldar, Mario R Capecchi, Kevin B Jones
Synovial sarcoma (SS) is an aggressive soft-tissue sarcoma that is often discovered during adolescence and young adulthood. Despite the name, synovial sarcoma does not typically arise from a synoviocyte but instead arises in close proximity to bones. Previous work demonstrated that mice expressing the characteristic SS18-SSX fusion oncogene in myogenic factor 5-expressing (Myf5-expressing) cells develop fully penetrant sarcomagenesis, suggesting skeletal muscle progenitor cell origin. However, Myf5 is not restricted to committed myoblasts in embryos but is also expressed in multipotent mesenchymal progenitors...
November 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29196819/an-effective-delivery-vehicle-of-demineralized-bone-matrix-incorporated-with-engineered-collagen-binding-human-bone-morphogenetic-protein-2-to-accelerate-spinal-fusion-at-low-dose
#19
Weiguo Zhu, Yong Qiu, Fei Sheng, Xinxin Yuan, Leilei Xu, Hongda Bao, Jianwu Dai, Zezhang Zhu
The aim of this study was to investigate the feasibility and efficacy of a new delivery matrix using demineralized bone matrix (DBM) incorporated with collagen-binding bone morphogenetic protein-2 (CBD-BMP-2) in the rat inter-transverse spinal fusion model. Sixty rats undergoing posterolateral (inter-transverse) spinal fusion were divided into 3 groups according to the fusion materials containing different components (n = 20 per group). Group A were implanted with DBM, Group B with combination of DBM and BMP-2 and Group C with combination of DBM and CBD-BMP-2...
December 1, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29191096/lumbar-computed-tomography-scans-are-not-appropriate-surrogates-for-bone-mineral-density-scans-in-primary-adult-spinal-deformity
#20
Eitan M Kohan, Venu M Nemani, Stuart Hershman, Daniel G Kang, Michael P Kelly
OBJECTIVE The authors examined the correlation between lumbar spine CT Hounsfield unit (HU) measurements and bone mineral density measurements in an adult spinal deformity (ASD) population. METHODS Patients with ASD were identified in the records of a single institution. Lumbar CT scans were reviewed, and the mean HU measurements from L1-4 were recorded. Bone mineral density (BMD) was assessed using femoral neck and lumbar spine dual-energy x-ray absorptiometry (DEXA). The number of patients who met criteria for osteoporosis was determined for each imaging modality...
December 2017: Neurosurgical Focus
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