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Mutong Xie, Mingyang Zhao, Mingzheng Lei, Yongle Wu, Yuanan Liu, Xinlu Gao, Shanguo Huang
An optically-controlled phase-tunable microwave mixer based on a dual-drive dual-parallel Mach-Zehnder modulator (DDDP-MZM) is proposed, which supports wideband phase shift and immunity to power fading caused by chromatic dispersion. By using carrier-suppressed single side-band (CS-SSB) modulation for the local oscillator (LO) signal and carrier-suppressed double side-band (CS-DSB) modulation for the input signal, no vector superposition for the same output microwave frequency occurs, making the system immune from power fading caused by chromatic dispersion...
January 8, 2018: Optics Express
Wenjian Yang, Shijie Song, Xiaoke Yi, Suen Xin Chew, Liwei Li, Linh Nguyen
A novel, highly sensitive integrated sensor based on a silicon-on-insulator microring resonator is proposed and experimentally demonstrated. To achieve a fast-response and cost-effective sensing system, the new structure establishes a linear amplitude comparison sensing function (ACSF) by monitoring the optical powers from both the through port and drop port of an add-drop microring resonator simultaneously, where the contrast of the two ports eliminates the effect of unexpected power fluctuation of the input laser on sensor performance...
January 1, 2018: Optics Letters
Giuseppe Di Bella, Biagio Colori, Rosilde Toscano
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof...
December 4, 2017: Neuro Endocrinology Letters
Sadok Bdiri, Faouzi Derbel, Olfa Kanoun
A novel wake-up receiver for wireless sensor networks is introduced. It operates with a modified medium access protocol (MAC), allowing low-energy consumption and practical latency. The ultra-low-power wake-up receiver operates with enhanced duty-cycled listening. The analysis of energy models of the duty-cycle-based communication is presented. All the WuRx blocks are studied to obey the duty-cycle operation. For a mean interval time for the data exchange cycle between a transmitter and a receiver over 1.7 s and a 64-bit wake-up packet detection latency of 32 ms, the average power consumption of the wake-up receiver (WuRx) reaches down to 3 μ W ...
December 29, 2017: Sensors
Yashar Zeighami, Seyed-Mohammad Fereshtehnejad, Mahsa Dadar, D Louis Collins, Ronald B Postuma, Bratislav Mišić, Alain Dagher
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a wide array of motor and non-motor symptoms. It remains unclear whether neurodegeneration in discrete loci gives rise to discrete symptoms, or whether network-wide atrophy gives rise to the unique behavioural and clinical profile associated with PD. Here we apply a data-driven strategy to isolate large-scale, multivariate associations between distributed atrophy patterns and clinical phenotypes in PD. In a sample of N = 229 de novo PD patients, we estimate disease-related atrophy using deformation based morphometry (DBM) of T1 weighted MR images...
December 19, 2017: NeuroImage
Mitra Hosseinifar, Vahid Ahmadi, Majid Ebnali-Heidari
This Letter presents a new family of Schottky graphene/silicon (Si) photodetectors (PDs) based on hollow-core photonic crystal fibers (HPCFs), working at both optical communication and room temperature. The proposed structure has the advantage of plasmonic HPCFs in a slow-light regime, and the absorption mechanism is based on an internal photoemission effect. The main feature of this structure is that the enhanced electric field is strongly localized in the hollow core of the guided core mode with the surface plasmon modes at the surface metal wires embedded in the photonic crystal structure...
December 15, 2017: Optics Letters
Eslam El-Fiky, Mohamed Osman, Mohammed Sowailem, Alireza Samani, David Patel, Rui Li, Md G Saber, Yun Wang, Nicolas Abadia, Yannick D'Mello, David V Plant
We present a dual-polarization O-band silicon photonic (SiP) transmitter for intra-datacenter optical interconnects. The transmitter is built using two identical O-band traveling wave Mach-Zehnder modulators with an average VπL and a bandwidth at 1.5 V bias voltage of 2.88 and 24.5 GHz, respectively. We experimentally demonstrate the transmitter in a Stokes vector direct-detection (SV-DD) system for dual-polarization intensity modulated signals with 2-level and 4-level pulse amplitude modulation (DP-PAM2 and DP-PAM4) formats...
November 27, 2017: Optics Express
Weiguo Zhu, Yong Qiu, Fei Sheng, Xinxin Yuan, Leilei Xu, Hongda Bao, Jianwu Dai, Zezhang Zhu
The aim of this study was to investigate the feasibility and efficacy of a new delivery matrix using demineralized bone matrix (DBM) incorporated with collagen-binding bone morphogenetic protein-2 (CBD-BMP-2) in the rat inter-transverse spinal fusion model. Sixty rats undergoing posterolateral (inter-transverse) spinal fusion were divided into 3 groups according to the fusion materials containing different components (n = 20 per group). Group A were implanted with DBM, Group B with combination of DBM and BMP-2 and Group C with combination of DBM and CBD-BMP-2...
December 1, 2017: Journal of Materials Science. Materials in Medicine
Lianyun Lin, Chen Liu, Juan Qin, Jie Wang, Shengjie Dong, Wei Chen, Weiyi He, Qingzhi Gao, Minsheng You, Zhiguang Yuchi
Ryanodine receptors (RyRs) are large calcium-release channels located in sarcoplasmic reticulum membrane. They play a central role in excitation-contraction coupling of muscle cells. Three commercialized insecticides targeting pest RyRs generate worldwide sales over 2 billion U.S. dollars annually, but the structure of insect RyRs remains elusive, hindering our understanding of the mode of action of RyR-targeting insecticides and the development of insecticide resistance in pests. Here we present the crystal structure of RyR N-terminal domain (NTD) (residue 1-205) at 2...
December 2, 2017: Insect Biochemistry and Molecular Biology
Da-Song Chen, Jian-Qing Dai, Shi-Chou Han
The diamondback moth was estimated to increase costs to the global agricultural economy as the global area increase of Brassica vegetable crops and oilseed rape. Sex pheromones traps are outstanding tools available in Integrated Pest Management for many years and provides an effective approach for DBM population monitoring and control. The ratio of two major sex pheromone compounds shows geographical variations. However, the limitation of our information in the DBM pheromone biosynthesis dampens our understanding of the ratio diversity of pheromone compounds...
November 24, 2017: Scientific Reports
Fahimeh Sadat Tabatabaei, Ramin Samadi, Saeed Tatari
BACKGROUND: Reconstruction of bone defects is often performed using bone autografts. However, limitations associated with the use of autografts led to the use of bone substitute materials. OBJECTIVES: The purpose of this study was to compare the surface characteristics of three commercially available grafts namely allografts, xenografts and alloplasts. METHODS: This in vitro study was conducted on beta-tricalcium phosphate (β-TCP) alloplast, a mixture of demineralized bone matrix and mineralized bone allograft (DBM&MBA) and natural bovine bone mineral (NBBM) xenograft...
2017: Bio-medical Materials and Engineering
Alexander R Hoberman, Carl Cirino, Mary Beth McCarthy, Mark P Cote, Leo Pauzenberger, Knut Beitzel, Augustus D Mazzocca, Felix Dyrna
PURPOSE: To assess the response of bone marrow-derived mesenchymal stromal cells (bMSCs) enhanced by platelet-rich plasma (PRP) in the setting of a normal human tendon (NHT), a demineralized bone matrix (DBM), and a fibrin scaffold (FS) with simulated arthroscopic mechanical washout stress. METHODS: Bone marrow was aspirated from the humeral head and concentrated. BMSCs were counted, plated, and grown to confluence. Cells were seeded onto 3 different scaffolds: (1) NHT, (2) DBM, and (3) FS...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
Md Nasar Mallick, Washim Khan, Rabea Parveen, Sayeed Ahmad, Sadaf, Mohammad Zeeshan Najm, Istaq Ahmad, Syed Akhtar Husain
Background: Bacopa monnieri (BM) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. We hypothesized that the extract of the whole plant might contain numerous molecules with having antitumor activities that could be very effective in killing of human cancer cells. Objectives: This work investigated anticancer activity of bioactive fraction of BM. Materials and Methods: The hydroalcoholic extract of BM was fractionated with different solvent, namely, hexane, dichloromethane (DCM), acetone, methanol, and water...
October 2017: Pharmacognosy Magazine
Olga Matatkova, Lucia Gharwalova, Michal Zimola, Tomas Rezanka, Jan Masak, Irena Kolouchova
We investigated the possibility of utilizing unusual carbon sources by three yeast strains: Candida krusei DBM 2136, Trichosporon cutaneum CCY 30-5-10, and Yarrowia lipolytica CCY 30-26-36. These strains are characterized by high biomass yield, ability to accumulate high amounts of lipids, and their potential as producers of dietetically important fatty acids. The aim of this work was the production of nutritionally important fatty acids by utilization of n-alkanes with an odd number of carbon atoms, alone and in combination with glucose and subsequent analysis of microbial lipids accumulation and fatty acid profile...
2017: International Journal of Analytical Chemistry
Adam T Hexter, Catherine Pendegrass, Fares Haddad, Gordon Blunn
Background: Following injury to the rotator cuff and anterior cruciate ligament, a direct enthesis is not regenerated, and healing occurs with biomechanically inferior fibrous tissue. Demineralized bone matrix (DBM) is a collagen scaffold that contains growth factors and is a promising biological material for tendon and ligament repair because it can regenerate a direct fibrocartilaginous insertion via endochondral ossification. Purpose: To provide a comprehensive review of the literature investigating the use of DBM to augment tendon-bone healing in tendon repair and anterior cruciate ligament reconstruction (ACLR)...
October 2017: Orthopaedic Journal of Sports Medicine
A Zizza, M Guido, M R Tumolo, A De Donno, F Bagordo, P Grima
Introduction: Cardiovascular Diseases (CD) have emerged as a leading cause of morbidity and mortality in HIV population. Some studies have reported higher carotid Intima Media Thickness (c-IMT), a measure of subclinical atherosclerosis (AT), in this cohort of patients. Methods: Here, we evaluate the role of Hepatic Steatosis (HS) as likely marker for AT in 128 HIV-infected patients without hepatitis C infection. c-IMT has been detected non-invasively by carotid ultrasonography to assess the progression of AT...
September 2017: Journal of Preventive Medicine and Hygiene
Chuandong Lin, Kai Hong Luo, Linlin Fei, Sauro Succi
We propose a multi-component discrete Boltzmann model (DBM) for premixed, nonpremixed, or partially premixed nonequilibrium reactive flows. This model is suitable for both subsonic and supersonic flows with or without chemical reaction and/or external force. A two-dimensional sixteen-velocity model is constructed for the DBM. In the hydrodynamic limit, the DBM recovers the modified Navier-Stokes equations for reacting species in a force field. Compared to standard lattice Boltzmann models, the DBM presents not only more accurate hydrodynamic quantities, but also detailed nonequilibrium effects that are essential yet long-neglected by traditional fluid dynamics...
November 6, 2017: Scientific Reports
Kingsley R Chin, Fabio J R Pencle, Jason A Seale, Juan M Valdivia
AIM: To assess use of demineralized bone matrix (DBM) use in anterior cervical discectomy and fusion (ACDF) in outpatient setting. METHODS: One hundred and forty-five patients with prospectively collected data undergoing single and two level ACDF with DBM packed within and anterior to polyetheretherketone (PEEK) cages. Two groups created, Group 1 (75) outpatients and control Group 2 (70) hospital patients. Prevertebral soft tissue swelling (PVSTS) was measured anterior to C2 and C6 on plain lateral cervical radiographs preoperatively and one week postoperatively and fusion assessed at two years...
October 18, 2017: World Journal of Orthopedics
Asrafi Rizki Gatam, Luthfi Gatam, Singkat Dohar Lumban Tobing
Study Design: Prospective, cohort, non-inferiority study. Purpose: This study evaluated the clinical and radiological outcomes of interbody fusion using a combination of demineralized bone matrix (DBM) and hydroxyapatite (HA). Overview of Literature: The use of autografts remains a gold standard in lumbar interbody fusion, but the limited availability and donor site morbidity encourages the use of bone substitutes. In addition to autografts, a combination of HA and DBM is being increasingly use for lumbar interbody fusion...
October 2017: Asian Spine Journal
Xiaoyan Liu, Suyu Yi, Xiaolin Zhou, Zhilai Fang, Zhi-Jun Qiu, Laigui Hu, Chunxiao Cong, Lirong Zheng, Ran Liu, Pengfei Tian
To enable high-speed long-distance underwater optical wireless communication (UOWC) supplementing traditional underwater wireless communication, a low-power 520 nm green laser diode (LD) based UOWC system was proposed and experimentally demonstrated to implement maximal communication capacity of up to 2.70 Gbps data rate over a 34.5 m underwater transmission distance by using non-return-to-zero on-off keying (NRZ-OOK) modulation scheme. Moreover, maximum data rates of up to 4.60 Gbps, 4.20 Gbps, 3.93 Gbps, 3...
October 30, 2017: Optics Express
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