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Alexander R Hoberman, Carl Cirino, Mary Beth McCarthy, Mark P Cote, Leo Pauzenberger, Knut Beitzel, Augustus D Mazzocca, Felix Dyrna
PURPOSE: To assess the response of bone marrow-derived mesenchymal stromal cells (bMSCs) enhanced by platelet-rich plasma (PRP) in the setting of a normal human tendon (NHT), a demineralized bone matrix (DBM), and a fibrin scaffold (FS) with simulated arthroscopic mechanical washout stress. METHODS: Bone marrow was aspirated from the humeral head and concentrated. BMSCs were counted, plated, and grown to confluence. Cells were seeded onto 3 different scaffolds: (1) NHT, (2) DBM, and (3) FS...
November 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
Md Nasar Mallick, Washim Khan, Rabea Parveen, Sayeed Ahmad, Sadaf, Mohammad Zeeshan Najm, Istaq Ahmad, Syed Akhtar Husain
Background: Bacopa monnieri (BM) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. We hypothesized that the extract of the whole plant might contain numerous molecules with having antitumor activities that could be very effective in killing of human cancer cells. Objectives: This work investigated anticancer activity of bioactive fraction of BM. Materials and Methods: The hydroalcoholic extract of BM was fractionated with different solvent, namely, hexane, dichloromethane (DCM), acetone, methanol, and water...
October 2017: Pharmacognosy Magazine
Olga Matatkova, Lucia Gharwalova, Michal Zimola, Tomas Rezanka, Jan Masak, Irena Kolouchova
We investigated the possibility of utilizing unusual carbon sources by three yeast strains: Candida krusei DBM 2136, Trichosporon cutaneum CCY 30-5-10, and Yarrowia lipolytica CCY 30-26-36. These strains are characterized by high biomass yield, ability to accumulate high amounts of lipids, and their potential as producers of dietetically important fatty acids. The aim of this work was the production of nutritionally important fatty acids by utilization of n-alkanes with an odd number of carbon atoms, alone and in combination with glucose and subsequent analysis of microbial lipids accumulation and fatty acid profile...
2017: International Journal of Analytical Chemistry
Adam T Hexter, Catherine Pendegrass, Fares Haddad, Gordon Blunn
Background: Following injury to the rotator cuff and anterior cruciate ligament, a direct enthesis is not regenerated, and healing occurs with biomechanically inferior fibrous tissue. Demineralized bone matrix (DBM) is a collagen scaffold that contains growth factors and is a promising biological material for tendon and ligament repair because it can regenerate a direct fibrocartilaginous insertion via endochondral ossification. Purpose: To provide a comprehensive review of the literature investigating the use of DBM to augment tendon-bone healing in tendon repair and anterior cruciate ligament reconstruction (ACLR)...
October 2017: Orthopaedic Journal of Sports Medicine
A Zizza, M Guido, M R Tumolo, A De Donno, F Bagordo, P Grima
Introduction: Cardiovascular Diseases (CD) have emerged as a leading cause of morbidity and mortality in HIV population. Some studies have reported higher carotid Intima Media Thickness (c-IMT), a measure of subclinical atherosclerosis (AT), in this cohort of patients. Methods: Here, we evaluate the role of Hepatic Steatosis (HS) as likely marker for AT in 128 HIV-infected patients without hepatitis C infection. c-IMT has been detected non-invasively by carotid ultrasonography to assess the progression of AT...
September 2017: Journal of Preventive Medicine and Hygiene
Chuandong Lin, Kai Hong Luo, Linlin Fei, Sauro Succi
We propose a multi-component discrete Boltzmann model (DBM) for premixed, nonpremixed, or partially premixed nonequilibrium reactive flows. This model is suitable for both subsonic and supersonic flows with or without chemical reaction and/or external force. A two-dimensional sixteen-velocity model is constructed for the DBM. In the hydrodynamic limit, the DBM recovers the modified Navier-Stokes equations for reacting species in a force field. Compared to standard lattice Boltzmann models, the DBM presents not only more accurate hydrodynamic quantities, but also detailed nonequilibrium effects that are essential yet long-neglected by traditional fluid dynamics...
November 6, 2017: Scientific Reports
Kingsley R Chin, Fabio J R Pencle, Jason A Seale, Juan M Valdivia
AIM: To assess use of demineralized bone matrix (DBM) use in anterior cervical discectomy and fusion (ACDF) in outpatient setting. METHODS: One hundred and forty-five patients with prospectively collected data undergoing single and two level ACDF with DBM packed within and anterior to polyetheretherketone (PEEK) cages. Two groups created, Group 1 (75) outpatients and control Group 2 (70) hospital patients. Prevertebral soft tissue swelling (PVSTS) was measured anterior to C2 and C6 on plain lateral cervical radiographs preoperatively and one week postoperatively and fusion assessed at two years...
October 18, 2017: World Journal of Orthopedics
Asrafi Rizki Gatam, Luthfi Gatam, Singkat Dohar Lumban Tobing
Study Design: Prospective, cohort, non-inferiority study. Purpose: This study evaluated the clinical and radiological outcomes of interbody fusion using a combination of demineralized bone matrix (DBM) and hydroxyapatite (HA). Overview of Literature: The use of autografts remains a gold standard in lumbar interbody fusion, but the limited availability and donor site morbidity encourages the use of bone substitutes. In addition to autografts, a combination of HA and DBM is being increasingly use for lumbar interbody fusion...
October 2017: Asian Spine Journal
Xiaoyan Liu, Suyu Yi, Xiaolin Zhou, Zhilai Fang, Zhi-Jun Qiu, Laigui Hu, Chunxiao Cong, Lirong Zheng, Ran Liu, Pengfei Tian
To enable high-speed long-distance underwater optical wireless communication (UOWC) supplementing traditional underwater wireless communication, a low-power 520 nm green laser diode (LD) based UOWC system was proposed and experimentally demonstrated to implement maximal communication capacity of up to 2.70 Gbps data rate over a 34.5 m underwater transmission distance by using non-return-to-zero on-off keying (NRZ-OOK) modulation scheme. Moreover, maximum data rates of up to 4.60 Gbps, 4.20 Gbps, 3.93 Gbps, 3...
October 30, 2017: Optics Express
Haritz Iribas, Jon Mariñelarena, Cheng Feng, Javier Urricelqui, Thomas Schneider, Alayn Loayssa
We report on two previously unknown non-local effects that have been found to impair Brillouin optical time-domain analysis (BOTDA) sensors that deploy limited extinction ratio (ER) pump pulses. The first one originates in the increased depletion of the pedestal of the pump pulses by the amplified probe wave, which in turn entails a reduced amplification of the probe and a measurement distortion. The second effect is due to the interplay between the transient response of the erbium-doped fiber amplifiers (EDFA) that are normally deployed to amplify the pump and the pedestal of the pump pulses...
October 30, 2017: Optics Express
Zhuopeng Xiao, Qunbi Zhuge, Songnian Fu, Fangyuan Zhang, Meng Qiu, Ming Tang, Deming Liu, David V Plant
A split digital backpropagation (DBP) scheme for digital subcarrier-multiplexing (SCM) transmissions, denoted as SSDBP, is proposed and studied in both experiments and simulations. The implementation of the SSDBP is split at the transmitter and the receiver, leveraging existing chromatic dispersion (CD) compensation blocks to reduce complexity. We experimentally demonstrate that the SSDBP, with a complexity reduction up to 50% compared to the original receiver based SCM-DBP, can achieve a nonlinear compensation Q(2) gain of 0...
October 30, 2017: Optics Express
Filippo Scotti, Daniel Onori, Claudio Porzi, Fabio Falconi, Vito Sorianello, Andreia Alves, Muhammad Imran, Sergio Pinna, Arismar Cerqueira, Marco Romagnoli, Antonella Bogoni
An innovative and effective architecture for lidar systems is presented and experimentally demonstrated. The proposed scheme can also be easily exploited for optical communications. In particular, the system includes an innovative lidar software-defined architecture based on optically coherent detection, overcoming current drawbacks of time of flight incoherent systems. The experiments demonstrate the ability to perform long range detection resorting to the waveform compression on the continuous wave approach, obtaining a range resolution of 15 cm with a sensitivity of -95  dBm...
November 1, 2017: Applied Optics
Hojong Choi, Chulwoo Park, Jungsuk Kim, Hayong Jung
The impact of high-voltage-high-frequency (HVHF) amplifiers on echo-signal quality is greater with very-high-frequency (VHF, ≥100 MHz) ultrasound transducers than with low-frequency (LF, ≤15 MHz) ultrasound transducers. Hence, the bias voltage of an HVHF amplifier must be stabilized to ensure stable echo-signal amplitudes. We propose a bias-voltage stabilizer circuit to maintain stable DC voltages over a wide input range, thus reducing the harmonic-distortion components of the echo signals in VHF pulse-echo measurement systems...
October 23, 2017: Sensors
Agnese Petrini, Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Bruno Therrien, Agustı N Galindo, Rosario Scopelliti, Tina Riedel, Paul J Dyson
A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [Cp*M(DBM/HDB/AVB)Cl] and [Cp*M(DBM/HDB/AVB)(PTA)][SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydibenzoylmethane, AVBH = avobenzone, and PTA = 1,3,5-triaza-7-phosphaadamantane, is reported. All the complexes were characterized by IR, (1)H and (13)C NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis, and DFT calculations. Five of the complexes have also been characterized in the solid-state by X-ray crystallography...
November 6, 2017: Inorganic Chemistry
Zhihua Tu, Qiang Jin, Hangyu Bai, Xiaoyan Wang, Shiming Gao
Nonlinear enhancement is experimentally demonstrated by depositing graphene scraps from graphene ethanol dispersion onto a tapered microfiber. The enhancement of the nonlinearity is verified by observing the four-wave mixing (FWM) effect in the homemade graphene-deposited microfiber (GDMF). When the incident pump power is 24.2 dBm, the FWM conversion efficiency in the GDMF reaches -57.1  dB. Compared to the bare microfiber with the same dimensions, the conversion efficiency is improved by more than 3 dB...
June 20, 2017: Applied Optics
Wu-Xun Peng, Lei Wang
BACKGROUND: This study investigated the effect of using adenovirus-mediated expression of bone morphogenetic protein 2 (Ad-BMP-2) and basic fibroblast growth factor (bFGF) in bone marrow mesenchymal stem cells (BMSCs) in combination with a demineralized bone matrix (DBM) to repair osteonecrosis of the femoral head (ONFH) in Beagle dogs. METHODS: A total of 30 Beagle dogs were selected for the isolation of BMSCs, which were cultured and transfected with the recombinant adenovirus vector Ad-BMP2-bFGF-GFP (carrying BMP-2 and bFGF) or a control adenovirus plasmid (encoding green fluorescent protein (Ad-GFP))...
2017: Cellular Physiology and Biochemistry
Chien-Hung Yeh, Yuan-Hong Zhuang, Ning Tsai, Chi-Wai Chow
In the investigation, we propose and demonstrate a wavelength-selectable C- plus L-band erbium-doped fiber (EDF) ring laser with single-longitudinal-mode (SLM) output. Here, a C-band erbium-doped fiber amplifier (EDFA) is utilized to serve as gain medium together with proposed multi-cross-ring (MCR) scheme to extend the wavelength tunability to L-band range. Besides, the MCR can also suppress the multi-longitudinal-mode (MLM) significantly. Therefore, the measured output power and optical signal to noise ratio (OSNR) of each lasing wavelength are between -10...
September 4, 2017: Optics Express
Pawel Zwolak, Jan Farei-Campagna, Thorsten Jentzsch, Brigitte von Rechenberg, Clément M Werner
BACKGROUND: Posterolateral spinal fusion is a common orthopaedic surgery performed to treat degenerative and traumatic deformities of the spinal column. In posteriolateral spinal fusion, different osteoinductive demineralized bone matrix products have been previously investigated. We evaluated the effect of locally applied zoledronic acid in combination with commercially available demineralized bone matrix putty on new bone formation in posterolateral spinal fusion in a murine in vivo model...
October 10, 2017: Archives of Orthopaedic and Trauma Surgery
Jie-Liang Yang, Xuan Yao, Quan Qing, Yi Zhang, Yan-Lin Jiang, Liang-Ju Ning, Jing-Cong Luo, Ting-Wu Qin
Demineralized bone matrix (DBM), as an extracellular matrix (ECM), has had limited use as a medical replacement although studies have reported a possibility for its use in tendon or ligament tissue engineering. To be an acid-extracted organic matrix, DBM contains much of bone protein, with a small amount of inorganic solids and some cell debris. However, cell debris is a critical factor that triggers inflammatory reaction in clinical reconstructions using ECM. In this study, we used a protocol incorporating the use of detergent with nuclease treatment to prepare decellularized DBM (DCDBM)...
October 6, 2017: Journal of Biomedical Materials Research. Part A
Hideyuki Tabata, Mayumi Enseki, Mariko Nukaga, Kota Hirai, Shinichi Matsuda, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND AND OBJECTIVE: An effort-independent breath sound analysis is expected to be a safe and simple method for clinical assessment of changes in airway function. The effects of bronchoconstriction and bronchodilation on novel breath sound parameters in asthmatic children were investigated. METHODS: The study population included 49 children with atopic asthma (male = 33; mean age: 10.2 years). We evaluated breath sound parameters of the highest frequency of the power spectrum (HFp), frequency limiting 50% and 99% of the power spectrum (F50 and F99 ) and roll-off from 600 Hz to the HFp (Slope)...
September 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
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