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https://www.readbyqxmd.com/read/28214897/mir-125b-regulates-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells-by-targeting-bmpr1b
#1
Huaqing Wang, Zhao Xie, Tianyong Hou, Zhiqiang Li, Ke Huang, Jicheng Gong, Wei Zhou, Kanglai Tang, Jianzhong Xu, Shiwu Dong
BACKGROUND/AIMS: Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a crucial role in bone regeneration and bone reparation. This complex process is regulated precisely and firmly by specific factors. Recent studies have demonstrated that miR-125b regulates osteogenic differentiation, but little is known about the molecular mechanisms of this regulation. Furthermore, how miR-125b regulates the osteogenic differentiation of MSCs still needs elucidation. METHODS: In the present study, human bone marrow-derived mesenchymal stem cells (hBMSCs) were isolated and induced to osteoblasts with miR-125b inhibition or overexpression...
January 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28207623/feasibility-of-percutaneous-posterolateral-spinal-fusion-with-recombinant-bone-morphogenetic-protein-2-rhbmp-2-a-comparison-with-standard-methods-using-an-animal-model-study
#2
Chris Yin Wei Chan, Mun Keong Kwan, Lim Beng Saw, Hussin Paisal
BACKGROUND CONTEXT: The clinical application of recombinant bone morphogenetic protein in spinal surgery has been shown to be safe and effective. However, its use in minimally invasive spine surgery has been limited to anterior interbody fusion procedures. To date, no study has evaluated the feasibility of percutaneous posterolateral fusion in the spine utilizing recombinant bone morphogenetic protein-2 (rhBMP-2). PURPOSE: To evaluate the feasibility of percutaneous posterolateral fusion in the spine utilizing rhBMP-2...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28193541/a-nano-scaled-and-multi-layered-recombinant-fibronectin-cadherin-chimera-composite-selectively-concentrates-osteogenesis-related-cells-and-factors-to-aid-bone-repair
#3
Junchao Xing, Tieniu Mei, Keyu Luo, Zhiqiang Li, Aijun Yang, Zhilin Li, Zhao Xie, Zehua Zhang, Shiwu Dong, Tianyong Hou, Jianzhong Xu, Fei Luo
: Easily accessible and effective bone grafts are in urgent need in clinic. The selective cell retention (SCR) strategy, by which osteogenesis-related cells and factors are enriched from bone marrow into bio-scaffolds, holds great promise. However, the retention efficacy is limited by the relatively low densities of osteogenesis-related cells and factors in marrow; in addition, a lack of satisfactory surface modifiers for scaffolds further exacerbates the dilemma. To address this issue, a multi-layered construct consisting of a recombinant fibronectin/cadherin chimera was established via a layer-by-layer self-assembly technique (LBL-rFN/CDH) and used to modify demineralised bone matrix (DBM) scaffolds...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28188395/marshall-r-urist-and-the-discovery-of-bone-morphogenetic-proteins
#4
Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Over the last 40 years International Orthopaedics has published a series of articles on bone morphogenetic proteins (BMPs) covering topics from basic research to clinical applications. This includes also work submitted from the Laboratory for Mineralized Tissues of the School of Medicine University of Zagreb. Accordingly, we felt obliged to give a short summary of Dr. Urist's life and work as our gratitude to his discovery that demineralized bone matrix (DBM) activity induces bone when implanted ectopically into the muscle or under the skin due to bone inducing proteins, named BMPs...
February 11, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28168366/evolution-of-patency-rates-of-self-expandable-bare-metal-stents-for-endovascular-treatment-of-femoro-popliteal-arterial-occlusive-disease-does-stent-design-matter
#5
Karla Maria Treitl, Benedikt Woerner, Regina Schinner, Michael Czihal, Susan Notohamiprodjo, Ulrich Hoffmann, Marcus Treitl
OBJECTIVE: To analyse the patency rates of femoro-popliteal stenting with different self-expandable Nitinol stent-designs. METHODS: Two hundred and twenty-two patients (142 (64%) male; age 72.4 ± 11.6 years) with symptomatic femoro-popliteal peripheral arterial occlusive disease (PAOD) underwent percutaneous transluminal angioplasty (PTA) and stenting with three different Nitinol stents (interwoven IW: n = 70; closed-cell CC: n = 85; open-cell OC: n = 67)...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28162888/the-effectiveness-of-demineralized-cortical-bone-matrix-in-a-chronic-rotator-cuff-tear-model
#6
Tanujan Thangarajah, Frederick Henshaw, Anita Sanghani-Kerai, Simon M Lambert, Gordon W Blunn, Catherine J Pendegrass
BACKGROUND: The purpose of this study was to assess the effect of demineralized bone matrix (DBM) on rotator cuff tendon-bone healing. The hypothesis was that compared with a commercially available dermal matrix scaffold, DBM would result in a higher bone mineral density and regenerate a morphologically superior enthesis in a rat model of chronic rotator cuff degeneration. METHODS: Eighteen female Wistar rats underwent unilateral detachment of the supraspinatus tendon...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28159330/neurosurgery-of-the-future-deep-brain-stimulations-and-manipulations
#7
Stylianos Nicolaidis
Important advances are afoot in the field of neurosurgery-particularly in the realms of deep brain stimulation (DBS), deep brain manipulation (DBM), and the newly introduced refinement "closed-loop" deep brain stimulation (CLDBS). Use of closed-loop technology will make both DBS and DBM more precise as procedures and will broaden their indications. CLDBS utilizes as feedback a variety of sources of electrophysiological and neurochemical afferent information about the function of the brain structures to be treated or studied...
January 11, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28158004/high-speed-underwater-optical-wireless-communication-using-a-blue-gan-based-micro-led
#8
Pengfei Tian, Xiaoyan Liu, Suyu Yi, Yuxin Huang, Shuailong Zhang, Xiaolin Zhou, Laigui Hu, Lirong Zheng, Ran Liu
High-speed underwater optical wireless communication (UOWC) was achieved using an 80 μm blue-emitting GaN-based micro-LED. The micro-LED has a peak emission wavelength of ~440 nm and an underwater power attenuation of 1 dB/m in tap water. The -3 dB electrical-to-optical modulation bandwidth of the packaged micro-LED increases with increasing current and saturates at ~160 MHz. At an underwater distance of 0.6 m, 800 Mb/s data rate was achieved with a bit error rate (BER) of 1.3 × 10<sup>-3</sup>, below the forward error correction (FEC) criteria...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28157990/low-power-consumption-and-continuously-tunable-all-optical-microwave-filter-based-on-an-opto-mechanical-microring-resonator
#9
Li Liu, Yue Yang, Zhihua Li, Xing Jin, Wenqin Mo, Xing Liu
We propose and experimentally demonstrate a continuously tunable all-optical microwave filter using a silicon opto-mechanical microring resonator (MRR). By finely adjusting the pump light with submilliwatt power level, transmission spectrum of the MRR could be continuously shifted based on the nonlinear effects, including the opto-mechanical effect and thermo-optic effect. Therefore, in the case of optical single sideband (OSSB) modulation, the frequency intervals between the optical carrier (near one MRR resonance) and the corresponding resonance could be flexibly manipulated, which is the critical factor to achieve continuously tunable microwave photonic filter (MPF)...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28150691/repair-of-bone-defects-with-prefabricated-vascularized-bone-grafts-and-double-labeled-bone-marrow-derived-mesenchymal-stem-cells-in-a-rat-model
#10
Xiao-Rui Jiang, Hui-Ying Yang, Xin-Xin Zhang, Guo-Dong Lin, Yong-Chun Meng, Pei-Xun Zhang, Shan Jiang, Chun-Lei Zhang, Fei Huang, Lin Xu
This study aims to investigate the repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells (BMSCs) in a rat model. BMSCs were separated from rat bone marrow. LTR-CMVpro-RFP and LTR-CMVpro-GFP were transfected into the BMSCs for in vitro and in vivo tracking. BMSCs-RFP and BMSCs-GFP were induced into endothelial progenitor cells (EPCs) and osteoblasts (OBs). Rats were divided into five groups: Group A: in vitro prefabrication with EPCs-RFP + in vivo prefabrication with arteriovenous vascular bundle + secondary OBs-GFP implantation; Group B: in vitro prefabrication with EPCs-RFP + secondary OBs-GFP implantation; Group C: in vivo prefabrication with arteriovenous vascular bundle + secondary OBs-GFP implantation; Group D: implantation of EPCs-RFP + implantation of with arteriovenous vascular bundle + simultaneous OBs-GFP implantation; Group E: demineralized bone matrix (DBM) grafts (blank control)...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28146533/chirp-based-direct-phase-modulation-of-vcsels-for-cost-effective-transceivers
#11
Jose A Altabas, David Izquierdo, Jose A Lazaro, Ignacio Garces
A 2.5  Gb/s differential binary phase-shift keying (DPSK) transmitter based on direct phase modulation of a vertical cavity surface emitting lasers (VCSEL) using its own chirp is proposed. The VCSEL, which has a wavelength of 1539.84 nm, has been characterized both statically and dynamically. The sensitivity of a single photodiode heterodyne receiver using the proposed 2.5  Gb/s VCSEL transmitter is -39.5  dBm. Thus, this transmitter is an extremely cost-effective solution for future access networks...
February 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28138909/colloidal-gels-with-extracellular-matrix-particles-and-growth-factors-for-bone-regeneration-in-critical-size-rat-calvarial-defects
#12
Jakob M Townsend, S Connor Dennis, Jonathan Whitlow, Yi Feng, Jinxi Wang, Brian Andrews, Randolph J Nudo, Michael S Detamore, Cory J Berkland
Colloidal gels encapsulating natural materials and exhibiting paste-like properties for placement are promising for filling complex geometries in craniofacial bone regeneration applications. Colloidal materials have demonstrated modest clinical outcomes as bone substitutes in orthopedic applications, but limited success in craniofacial applications. As such, development of a novel colloidal gel will fill a void in commercially available products for use in craniofacial reconstruction. One likely application for this technology is cranial reconstruction...
January 30, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28128364/periostin-upregulates-wnt-%C3%AE-catenin-signaling-to-promote-the-osteogenesis-of-ctla4-modified-human-bone-marrow-mesenchymal-stem-cells
#13
Fei Zhang, Keyu Luo, Zhigang Rong, Zhengdong Wang, Fei Luo, Zehua Zhang, Dong Sun, Shiwu Dong, Jianzhong Xu, Fei Dai
The enhanced osteogenesis of mesenchymal stem cells (MSCs) modified by expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been shown in previous studies, but the mechanism remains unknown. Here we found that the bone repair effect of CTLA4-modified MSCs in demineralized bone matrix (DBM) in a rabbit radius defect model was significantly better than that observed for unmodified MSCs in DBM or DBM alone, and the periostin (POSTN) expression in CTLA4-modified MSCs was significantly higher than that in unmodified MSCs both in vivo and in vitro...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28126356/efficacy-comparison-of-accell-evo3%C3%A2-and-grafton%C3%A2-demineralized-bone-matrix-putties-against-autologous-bone-in-a-rat-posterolateral-spine-fusion-model
#14
Antonio T Brecevich, Paul D Kiely, B Victor Yoon, Joseph T Nguyen, Frank P Cammisa, Celeste Abjornson
BACKGROUND CONTEXT: Spinal fusion procedures are intended to stabilize the spinal column for a multitude of disorders including abnormal curvature, traumatic instability, degenerative instability, and damage from infections or tumors. As an aid in the bone healing response, bone graft materials are utilized to bridge joints for arthrodesis and promote unions in pseudoarthrosis. Currently, the gold standard for stabilizing fusion masses in spinal procedures involves utilizing the osteogenic, osteoinductive, and osteoconductive properties of autologous iliac crest cortico-cancellous bone...
January 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28125033/a-11-mw-2-4-ghz-0-18-%C3%A2%C2%B5m-cmos-transceivers-for-wireless-sensor-networks
#15
Bing Hou, Hua Chen, Zhiyu Wang, Jiongjiong Mo, Junli Chen, Faxin Yu, Wenbo Wang
In this paper, a low power transceiver for wireless sensor networks (WSN) is proposed. The system is designed with fully functional blocks including a receiver, a fractional-N frequency synthesizer, and a class-E transmitter, and it is optimized with a good balance among output power, sensitivity, power consumption, and silicon area. A transmitter and receiver (TX-RX) shared input-output matching network is used so that only one off-chip inductor is needed in the system. The power and area efficiency-oriented, fully-integrated frequency synthesizer is able to provide programmable output frequencies in the 2...
January 24, 2017: Sensors
https://www.readbyqxmd.com/read/28113332/bio-witel-a-low-power-integrated-wireless-telemetry-system-for-healthcare-applications-in-401-406-mhz-band-of-medradio-spectrum
#16
Abhishek Srivastava, Nithin Sankar, Baibhab Chatterjee, Devarshi Das, Meraj Ahmad, Rakesh Kukkundoor, Vivek Saraf, Ananthpadmanabhan Jayachandran, Dinesh Sharma, Maryam Baghini
This paper presents a low power integrated wireless telemetry system (Bio-WiTel) for healthcare applications in 401- 406 MHz frequency band of Medical Device RadioCommunication (MedRadio) spectrum. In this work, necessary design considerations for telemetry system for short range (upto 3 m) communication of bio-signals are presented. These considerations greatly help in taking important design decisions, which eventually lead to a simple, low power, robust and reliable wireless system implementation. Transmitter (TX) and receiver (RX) of Bio-WiTel system have been fabricated in 180 nm mixed mode CMOS technology...
December 14, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28098189/global-identification-of-micrornas-associated-with-chlorantraniliprole-resistance-in-diamondback-moth-plutella-xylostella-l
#17
Bin Zhu, Xiuxia Li, Ying Liu, Xiwu Gao, Pei Liang
The diamondback moth (DBM), Plutella xylostella (L.), is one of the most serious cruciferous pests and has developed high resistance to most insecticides, including chlorantraniliprole. Previous studies have reported several protein-coding genes that involved in chlorantraniliprole resistance, but research on resistance mechanisms at the post-transcription level is still limited. In this study, a global screen of microRNAs (miRNAs) associated with chlorantraniliprole resistance in P. xylostella was performed...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28075373/visual-object-tracking-based-on-cross-modality-gaussian-bernoulli-deep-boltzmann-machines-with-rgb-d-sensors
#18
Mingxin Jiang, Zhigeng Pan, Zhenzhou Tang
Visual object tracking technology is one of the key issues in computer vision. In this paper, we propose a visual object tracking algorithm based on cross-modality featuredeep learning using Gaussian-Bernoulli deep Boltzmann machines (DBM) with RGB-D sensors. First, a cross-modality featurelearning network based on aGaussian-Bernoulli DBM is constructed, which can extract cross-modality features of the samples in RGB-D video data. Second, the cross-modality features of the samples are input into the logistic regression classifier, andthe observation likelihood model is established according to the confidence score of the classifier...
January 10, 2017: Sensors
https://www.readbyqxmd.com/read/28067859/a-wirelessly-powered-smart-contact-lens-with-reconfigurable-wide-range-and-tunable-sensitivity-sensor-readout-circuitry
#19
Jin-Chern Chiou, Shun-Hsi Hsu, Yu-Chieh Huang, Guan-Ting Yeh, Wei-Ting Liou, Cheng-Kai Kuei
This study presented a wireless smart contact lens system that was composed of a reconfigurable capacitive sensor interface circuitry and wirelessly powered radio-frequency identification (RFID) addressable system for sensor control and data communication. In order to improve compliance and reduce user discomfort, a capacitive sensor was embedded on a soft contact lens of 200 μm thickness using commercially available bio-compatible lens material and a standard manufacturing process. The results indicated that the reconfigurable sensor interface achieved sensitivity and baseline tuning up to 120 pF while consuming only 110 μW power...
January 7, 2017: Sensors
https://www.readbyqxmd.com/read/28063652/molecular-and-carbon-isotopic-characterization-of-an-anaerobic-stable-enrichment-culture-containing-dehalobacterium-sp-during-dichloromethane-fermentation
#20
Alba Trueba-Santiso, Eloi Parladé, Mònica Rosell, Marc Lliros, Siti Hatijah Mortan, Maira Martínez-Alonso, Nuria Gaju, Lucía Martín-González, Teresa Vicent, Ernest Marco-Urrea
: Biodegradation of dichloromethane (DCM) under reducing conditions is of major concern due to its widespread detection in contaminated groundwaters. Here, we report an anaerobic enrichment culture derived from a membrane bioreactor operating in an industrial wastewater treatment plant, capable of fermenting DCM and the brominated analogue dibromomethane (DBM). Comparative analysis of bacterial 16S rDNA-DGGE profiles from fresh liquid medium inoculated with single colonies picked from serial dilution-to-extinction agar vials showed that cultures degrading DCM contained a predominant band belonging to Dehalobacterium, however this band was absent in cultures unable to degrade DCM...
January 4, 2017: Science of the Total Environment
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