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https://www.readbyqxmd.com/read/28733366/the-available-evidence-on-demineralised-bone-matrix-in-trauma-and-orthopaedic-surgery-a-systematic-review
#1
J van der Stok, K A Hartholt, D A L Schoenmakers, J J C Arts
OBJECTIVES: The aim of this systematic literature review was to assess the clinical level of evidence of commercially available demineralised bone matrix (DBM) products for their use in trauma and orthopaedic related surgery. METHODS: A total of 17 DBM products were used as search terms in two available databases: Embase and PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses statement. All articles that reported the clinical use of a DBM-product in trauma and orthopaedic related surgery were included...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28728414/putting-a-new-spin-on-supramolecular-metallacycles-co3-triangle-and-co4-square-bearing-tetrazine-based-radicals-as-bridges
#2
Dimitris I Alexandropoulos, Brian S Dolinar, Kuduva R Vignesh, Kim R Dunbar
The synthesis of two new radical bridged compounds [Co3(bptz)3(dbm)3]∙2toluene (1) and [Co4(bptz)4(dbm)4]∙4MeCN (2) (bptz = 3,6-bis(pyridyl)-1,2,4,5-tetrazine; dbm = 1,3-diphenyl-1,3-propanedione) is reported. The presence of the ligand-centered radical has been confirmed by X-ray crystallography and SQUID magnetometry. These complexes are the first metallacycles bearing nitrogen heterocyclic radicals as bridges. Magnetic studies reveal strong antiferromagnetic metal···radical coupling with coupling constants of J = -67...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28687387/hybrid-hydrogels-with-high-strength-and-biocompatibility-for-bone-regeneration
#3
Yongjiang Zheng, Keqing Huang, Xinru You, Bingxue Huang, Jun Wu, Zhipeng Gu
The development of hydrogels for bone regeneration has highlighted the challenge that load-bearing hydrogels need to be biocompatible while achieving high strength. Several approaches have been reported to improve the toughness of hydrogels, but achieving high toughness and biocompatibility simultaneously remains a challenge. Here we report a polyacrylic acid/alginate/demineralized bone matrix (PAA/Alg/DBM) hybrid double network hydrogel, which was synthesized by a two-step sequential polymerization with embedded DBM, possessing both high strength and biocompatibility...
July 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28684346/antibiotic-loaded-bone-graft-for-reduction-of-surgical-site-infection-in-spinal-fusion
#4
Stefanie M Shiels, Vivek P Raut, Patrick B Patterson, Brian R Barnes, Joseph C Wenke
BACKGROUND CONTEXT: Infections remain a leading complication associated with spinal arthrodesis, regardless of the use of prophylactic antibiotics and improved surgical techniques, with incidence of infection as high as 8.2%. Infection prolongs antibiotic usage, increases hospital time, and inevitably inflates overall treatment costs. Local antibiotics, such as vancomycin, have been used in combination with fusion materials over the past decade to decrease infection risk. An ideal graft material would serve a dual role: encourage vertebral fusion while reducing incidence of infection...
July 3, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28656816/annals-express-quantitative-measurement-of-a-candidate-serum-biomarker-peptide-derived-from-%C3%AE-2-hs-glycoprotein-and-a-preliminary-trial-of-multi-dimensional-peptide-analysis-in-females-with-pregnancy-induced-hypertension
#5
Kensuke Hamamura, Mitsuaki Yanagida, Hitoshi Ishikawa, Michio Banzai, Hiroshi Yoshitake, Daisuke Nonaka, Kenji Tanaka, Mayumi Sakuraba, Yasuka Miyakuni, Kenji Takamori, Michio Nojima, Koyo Yoshida, Hiroshi Fujiwara, Satoru Takeda, Yoshihiko Araki
PURPOSE: We previously attempted to develop quantitative enzyme-linked immunosorbent assay (ELISA) systems for the PDA039/044/071 peptides, potential serum disease biomarkers (DBMs) of pregnancy-induced hypertension (PIH), primarily identified by a peptidomic approach (BLOTCHIP(®)-mass spectrometry (MS)). However, our methodology did not extend to PDA071 (cysteinyl α2-HS-glycoprotein341-367), due to difficulty to produce a specific antibody against the peptide. The aim of the present study was to establish an alternative PDA071 quantitation system using liquid chromatography-multiple reaction monitoring (LC-MRM )/MS, to explore the potential utility of PDA071 as a DBM for PIH...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28654835/sensitized-green-emission-of-terbium-with-dibenzoylmethane-and-1-10-phenanthroline-in-polyvinyl-alcohol-and-polyvinyl-pyrrolidone-blends
#6
Brijesh Kumar, Gagandeep Kaur, S B Rai
Tb doped polyvinyl alcohol: polyvinyl pyrrolidone blends with dibenzoylmethane (DBM) and 1, 10 Phenanthroline (Phen) have been prepared by solution cast technique. Bond formation amongst the ligands and Tb(3+) ions in the doped polymer has been confirmed employing Fourier Transform Infrared (FTIR) techniques. Optical properties of the Tb(3+) ions have been investigated using UV-Vis absorption, excitation and fluorescence studies excited by different radiations. Addition of dimethylbenzoate and 1, 10 Phenanthroline to the polymer blend increases the luminescence from Tb(3+) ions along with energy transfer from the polymer blend itself...
June 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28640296/synthesis-and-photophysical-and-magnetic-studies-of-ternary-lanthanide-iii-complexes-of-naphthyl-chromophore-functionalized-imidazo-4-5-f-1-10-phenanthroline-and-dibenzoylmethane
#7
A Josephine Kanimozhi, V Alexander
The luminescent ternary lanthanide(iii) complexes [Ln(DBM)3(L1)] and [Ln(DBM)3(L2)] (Ln = Eu and Tb) of dibenzoylmethane (DBM) and 2-(2-naphthyl)-1H-imidazo[4,5-f][1,10]phenanthroline (L1) and 2-(2-hydroxy-1-naphthyl)-1H-imidazo[4,5-f][1,10]phenanthroline (L2) are reported in this work. The naphthyl chromophore functionalized imidazophenanthroline ligands L1 and L2 are structurally characterized by using single crystal X-ray diffraction: (L1), a = 14.933(4) Å, b = 7.4965(13) Å, c = 15.999(4) Å, α = γ = 90°, β = 102...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28622184/does-age-influence-the-efficacy-of-demineralized-bone-matrix-enriched-with-concentrated-bone-marrow-aspirate-in-lumbar-fusions
#8
Remi M Ajiboye, Mark A Eckardt, Jason T Hamamoto, Akshay Sharma, Adam Z Khan, Jeffrey C Wang
STUDY DESIGN: Retrospective study. OBJECTIVE: Evaluate the effect of age on the efficacy of allograft/demineralized bone matrix (DBM) enriched with concentrated bone marrow aspirate (BMA) in posterolateral lumbar fusions (PLFs). SUMMARY OF BACKGROUND DATA: Cell-based therapies such as concentrated BMA have been developed as a potential alternative to iliac crest bone graft (ICBG). BMA contains mesenchymal stem cells (MSCs) and growth factors that can confer osteogenic and osteoinductive potential to osteoconductive scaffolds such as DBM/allograft...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28576299/effects-of-donor-breastmilk-feeding-on-growth-and-early-neurodevelopmental-outcomes-in-preterm-infants-an-observational-study
#9
Laura S Madore, Samudragupta Bora, Carmina Erdei, Tina Jumani, Allison R Dengos, Sarbattama Sen
PURPOSE: Donor breastmilk (DBM) has gained popularity as an alternative to formula when mother's own milk (MOM) is unavailable. The objective of this study was to evaluate the effects of a predominantly DBM diet on growth and subsequent neurodevelopment in preterm infants at a level 3 neonatal intensive care unit (NICU). METHODS: This single-center, observational cohort study compared data from preterm infants supplemented with predominantly (>50%) DBM to those from age- and weight-matched infants fed only MOM or supplemented with predominantly (>50%) preterm formula (PF)...
May 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28572578/integrated-fiber-optical-receiver-reducing-the-gap-to-the-quantum-limit
#10
Horst Zimmermann, Bernhard Steindl, Michael Hofbauer, Reinhard Enne
Experimental results of a single-photon avalanche diode (SPAD) based optical fiber receiver integrated in 0.35 µm PIN-photodiode CMOS technology are presented. To cope with the parasitic effects of SPADs an array of four receivers is implemented. The SPADs consist of a multiplication zone and a separate thick absorption zone to achieve a high photon detection probability (PDP). In addition cascoded quenchers allow to use a quenching voltage of twice the usual supply voltage, i.e. 6.6 V instead of 3.3 V, in order to increase the PDP further...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28571463/a-q-band-low-noise-gaas-phemt-mmic-power-amplifier-for-pulse-electron-spin-resonance-spectrometer
#11
A Sitnikov, E Kalabukhova, V Oliynyk, M Kolisnichenko
We present the design and development of a single stage pulse power amplifier working in the frequency range 32-38 GHz based on a monolithic microwave integrated circuit (MMIC). We have designed the MMIC power amplifier by using the commercially available packaged GaAs pseudomorphic high electron mobility transistor. The circuit fabrication and assembly process includes the elaboration of the matching networks for the MMIC power amplifier and their assembling as well as the topology outline and fabrication of the printed circuit board of the waveguide-microstrip line transitions...
May 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28556436/effect-of-recombinant-human-bone-morphogenic-protein-9-rhbmp9-loaded-onto-bone-grafts-versus-barrier-membranes-on-new-bone-formation-in-a-rabbit-calvarial-defect-model
#12
Masako Fujioka-Kobayashi, Eizaburo Kobayashi, Benoit Schaller, Matthias Mottini, Richard J Miron, Nikola Saulacic
Recent research has demonstrated that recombinant human bone morphogenetic protein 9 (rhBMP9) has been considered the most osteoinductive growth factor of the BMP-family. In the present study, rhBMP9 was investigated for its influence in combination with two biomaterials for bone regenerative medicine. Either porcine-derived collagen membrane (CM) or deproteinized bovine bone mineral (DBM) combined with 20 µg of rhBMP9 were implanted in 6 mm rabbit calvarial defects. Bone augmentation was evaluated by microCT and histomorphometry at 8 weeks post-surgery...
May 27, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28548246/comparison-of-three-different-types-of-scaffolds-preseeded-with-human-bone-marrow-mononuclear-cells-on-the-bone-healing-in-a-femoral-critical-size-defect-model-of-the-athymic-rat
#13
Maren Janko, Julian Sahm, Alexander Schaible, Jan C Brune, Marlene Bellen, Katrin Schröder, Caroline Seebach, Ingo Marzi, Dirk Henrich
Large bone defects often pose major difficulties in orthopedic surgery. The application of long term cultured stem cells combined with a scaffold lead to a significant improvement of bone healing in recent experiments but is strongly restricted by EU-law. Bone marrow mononuclear cells (BMC), however, can be isolated and transplanted within few hours and have been proven effective in experimental models of bone healing. The effectivity of the BMC supported therapy might be influenced by the type of scaffold...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28547589/stereotactic-radiosurgery-for-brain-metastases-from-primary-head-and-neck-carcinomas-a-retrospective-analysis
#14
Rajal A Patel, Jonathan B Bell, Thomas Kim, Mark Agulnik, James P Chandler, Bharat B Mittal, Tim J Kruser
Patients with head and neck malignancies commonly develop metastatic disease, yet rarely do these carcinomas metastasize to the brain. Stereotactic radiosurgery (SRS) is routinely employed to treat brain metastases (BM). This study was undertaken to examine the efficacy of SRS for BM from primary head and neck carcinomas. From 2000 to 2016, a total of 19 patients with 38 lesions were retrospectively identified. All patients presented with a primary head and neck malignancy and subsequently developed metastatic disease to the brain treated with SRS at our institution...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28541688/circularly-polarized-luminescence-of-silica-grafted-europium-chiral-derivatives-prepared-through-a-sequential-functionalization
#15
Lidia Armelao, Daniela Belli Dell'Amico, Luca Bellucci, Gregorio Bottaro, Lorenzo Di Bari, Luca Labella, Fabio Marchetti, Simona Samaritani, Francesco Zinna
We describe a new organic/inorganic material emitting circularly polarized luminescence (CPL). The hybrid system was obtained by the following steps: (i) preliminary grafting of the europium N,N-dibutylcarbamate [Eu(O2CNBu2)3] complex onto silica, (ii) substitution of the residual carbamato groups with anionic 1,3-diphenyl-1,3-propanedionato ligands (dbm), and (iii) subsequent introduction of the neutral tridentate chiral ligand 2,6-bis(isopropyl-2-oxazolin-2-yl)pyridine ((i)Pr-PyBox) in the metal coordination sphere...
May 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28512315/midgut-bacteria-in-deltamethrin-resistant-deltamethrin-susceptible-and-field-caught-populations-of-plutella-xylostella-and-phenomics-of-the-predominant-midgut-bacterium-enterococcus-mundtii
#16
Wenhong Li, Daochao Jin, Caihua Shi, Fengliang Li
Gut bacteria play a significant role in host insect. This study evaluated detail difference of midgut bacteria in deltamethrin-resistant, deltamethrin-susceptible and field-caught populations of diamondback moth, and studied phenomics of the predominant midgut bacterium Enterococcus mundtii. Cultivable bacteria revealed that E. mundtii and Carnobacterium maltaromaticum dominated the bacterial populations from deltamethrin-resistant and deltamethrin-susceptible larval midguts, whereas E. mundtii was predominant in field-caught population...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481087/influence-of-eu-iii-complexes-structural-anisotropy-on-luminescence-of-doped-conjugated-polymer-blends
#17
Andrey A Knyazev, Maksim E Karyakin, Aleksandr S Krupin, Ksenia A Romanova, Yuriy G Galyametdinov
Europium(III) complexes that are the anisometric analogues of a well-known Eu(DBM)3Phen (DBM = dibenzoylmethane; Phen = 1,10-phenanthroline) complex were synthesized. Quantum-chemical calculations of the excited states of new Eu(III) complexes and some conjugated polymers showed that poly(N-vinylcarbazole) provides the most efficient energy transfer in polymer films doped with synthesized Eu(III) complexes. These new composite films were prepared, and their luminescence properties were studied. The results of experimental data confirmed theoretical prediction about significant influence introduced in molecular structure long terminal alkyl chains and cyclohexane on the luminescence efficiency of "Ln(III)-polymer" composite...
May 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28468334/hybrid-integration-of-modified-uni-traveling-carrier-photodiodes-on-a-multi-layer-silicon-nitride-platform-using-total-reflection-mirrors
#18
Yang Shen, Shaoqi Feng, Xiaojun Xie, Jizhao Zang, Siwei Li, Tiehui Su, Kuanping Shang, Weicheng Lai, Guangyao Liu, S J Ben Yoo, Joe C Campbell
We demonstrate hybrid integration of modified uni-traveling carrier photodiodes on a multi-layer silicon nitride platform using total reflection mirrors etched by focused ion beam. The hybrid photodetectors show external responsivity of 0.15 A/W and bandwidth of 3.5 GHz for devices with a diameter of 80 µm. The insertion loss of the waveguide is 3 dB and the coupling efficiency of the total reflection mirror is -3 dB. The highest RF output power is -0.5 dBm measured at 3 GHz with 9 mA photocurrent and -9 V bias...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28467589/a-comparison-of-the-effects-of-platelet-rich-plasma-and-demineralized-bone-matrix-on-critical-bone-defects-an-experimental-study-on-rats
#19
Egemen Turhan, Mustafa Kemal Akça, Ahmet Bayar, Murat Songür, Selçuk Keser, Mahmut Nedim Doral
BACKGROUND: Delayed union of fractured bone is one of the main problems of orthopedics and traumatology practice. It was hypothesized that the beneficial effects of allogeneic platelet-rich plasma (PRP) would be valuable in the treatment of segmental bone defects. This study is a comparison of the effects of demineralized bone matrix (DBM) and PRP in a segmental bone defect model. METHODS: Total of 48 Wistar albino rats were separated into 4 groups. Segmental bone defect was created at right radius diaphysis in all specimens using dorsal approach...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28466936/a-near-infrared-organic-light-emitting-diode-based-on-an-yb-iii-complex-synthesized-by-vacuum-co-deposition
#20
Kazuya Jinnai, Ryota Kabe, Chihaya Adachi
Yb(DBM)3(DPEPO), an emitter, was directly synthesized on a substrate by the vacuum co-deposition of the precursor Yb(DBM)3(H2O)2 and the ligand DPEPO. OLEDs incorporating the co-deposited emitting layer (Yb(DBM)3(H2O)2 : DPEPO molar ratio = 1 : 1) achieved an ηEQE value of 0.15% at 1.0 mA cm(-2).
May 11, 2017: Chemical Communications: Chem Comm
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