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https://www.readbyqxmd.com/read/29932269/hypoxia-regulates-placental-angiogenesis-via-alternatively-activated-macrophages
#1
Hui Zhao, Flora S Kalish, Ronald J Wong, David K Stevenson
PROBLEM: Uterine and placental macrophages play critical roles in maintaining a normal pregnancy. The majority of these macrophages are believed to be alternatively activated macrophages (M2). METHOD OF STUDY: Mouse bone marrow cells were differentiated into macrophages and polarized to M2 in vitro by treatment with IL-4 [M2a] or IL-10 [M2c] and M1 with LPS/IFN-γ as controls. Macrophage subtypes were confirmed by surface markers and characterized by gene expression profiles...
June 22, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29931421/diabetes-myometrium-and-mitochondria-in-pregnant-women-at-term
#2
Christiane Marie Bourgin Folke Gam, Ole Hartvig Mortensen, Lea Hüche Larsen, Steen Seier Poulsen, Klaus Qvortrup, Elisabeth Reinhart Mathiesen, Peter Damm, Bjørn Quistorff
AIMS: Poor myometrial contractility has been demonstrated in women at term with diabetes and decreased muscular mitochondrial content and/or function has been extensively implicated in the progression of type 2 diabetes. Alterations of the uterine mitochondrial phenotype in pregnant women with diabetes have yet to be investigated as a causal link to decreased myometrial contractility. METHODS: Observational study of 18 women with diabetes (type 2 and gestational) scheduled for an elective Caesarean section at term with matching controls...
June 21, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29929445/hyperandrogenism-induces-histo-architectural-changes-in-the-rat-uterus
#3
Gisela Soledad Bracho, Gabriela Anahí Altamirano, Laura Kass, Enrique Hugo Luque, Verónica Lis Bosquiazzo
The effects of androgens on the uterus have been poorly studied and they need to be clarified to understand why androgen excess, such as observed in women with polycystic ovary syndrome (PCOS), is a risk factor for the development of endometrial hyperplasia, cancer, and infertility. Thus, uterine histomorphology in a PCOS experimental model was evaluated. Beginning at weaning, female rats were injected daily with dehydroepiandrosterone (DHEA, 6 mg/100 g body weight) or vehicle (sesame oil) for 20 consecutive days...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29928944/protective-effects-of-apigenin-on-lps-induced-endometritis-via-activating-nrf2-signaling-pathway
#4
Pei-Yue Jiang, Xiao-Jun Zhu, Yi-Na Zhang, Fei-Fei Zhou, Xiao-Fu Yang
Endometritis is a puzzling disease that often associates with severe pelvic pain. In this study, we aimed to detect whether apigenin had protective effect against LPS-induced endometritis, if so, the underlying mechanism was further investigated. Apigenin was administrated 1 h before LPS treatment. The levels of inflammatory cytokines were measured by ELISA. The expression of NF-κB and Nrf2 were detected by Western blot analysis. The results showed that LPS treatment induced severe histological alteration of uterus and this change was attenuated by the treatment of apigenin...
June 18, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29928930/effect-of-estetrol-a-selective-nuclear-estrogen-receptor-modulator-in-mouse-models-of-arterial-and-venous-thrombosis
#5
Marie-Cécile Valéra, Emmanuelle Noirrit-Esclassan, Marion Dupuis, Coralie Fontaine, Françoise Lenfant, Anne Briaux, Cendrine Cabou, Cedric Garcia, Olivier Lairez, Jean-Michel Foidart, Bernard Payrastre, Jean-François Arnal
Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the circulating level of coagulation factors, at variance to oral estradiol or ethinylestradiol. Here, we evaluated the effect of E4 on hemostasis and thrombosis in mouse. Following chronic E4 treatment, mice exhibited a prolonged tail-bleeding time and were protected from arterial and also venous thrombosis in vivo...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928508/a-parthenogenetic-quasi-program-causes-teratoma-like-tumors-during-aging-in-wild-type-c-elegans
#6
Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Alexandre Benedetto, Ann F Gilliat, Josephine Hellberg, Ziyu Ren, Evgeniy R Galimov, Trin Athigapanich, Johannes Girstmair, Maximilian J Telford, Colin T Dolphin, Zhizhou Zhang, David Gems
A long-standing belief is that aging (senescence) is the result of stochastic damage accumulation. Alternatively, senescent pathology may also result from late-life, wild-type gene action (i.e., antagonistic pleiotropy, as argued by Williams) leading to non-adaptive run-on of developmental programs (or quasi-programs ) (as suggested more recently by Blagosklonny). In this study, we use existing and new data to show how uterine tumors, a prominent form of senescent pathology in the nematode Caenorhabditis elegans , likely result from quasi-programs...
2018: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29928500/endometrial-response-to-conceptus-derived-estrogen-and-interleukin-1%C3%AE-at-the-time-of-implantation-in-pigs
#7
REVIEW
Hakhyun Ka, Heewon Seo, Yohan Choi, Inkyu Yoo, Jisoo Han
The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines, interleukin-1β2 (IL1B2), interferon-γ (IFNG), and IFN-δ (IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29928437/analysis-of-card10-and-card11-somatic-mutations-in-patients-with-ovarian-endometriosis
#8
Yang Zou, Jiang-Yan Zhou, Feng Wang, Zi-Yu Zhang, Fa-Ying Liu, Yong Luo, Jun Tan, Xin Zeng, Xi-Di Wan, Ou-Ping Huang
Endometriosis is a complex and heterogeneous pre-malignant inflammatory disease harboring multiple gene mutations. Previous studies have suggested that caspase recruitment domain family member (CARD)10 and CARD11 mutations may exist in endometriosis. In the present study, a collection of endometriotic lesions and paired peripheral blood from 101 patients with ovarian endometriosis were obtained, and the entire coding sequences of the CARD10 and CARD11 genes were sequenced. Evolutionary conservation analysis and online prediction programs were applied to analyze the disease-causing potential of the identified mutations...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928215/an-unusual-coexistence-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-with-endometrioid-type-endometrial-cancer-in-a-58-year-old-woman-a-case-study-with-literature-review
#9
Dominik Dłuski, Dorota Lewkowicz, Bożena Leszczyńska-Gorzelak, Bogdan Obrzut, Tomasz Rechberger, Andrzej Semczuk
Introduction: The coexistence of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with different gynecologic neoplasms is a rare phenomenon. Here, we report a case of simultaneously developed CLL/SLL with endometrioid-type uterine cancer. Case Report: A 58-year-old woman was admitted to the 2nd Department of Gynecology, Lublin Medical University, Lublin, Poland, in June 2017, where the uterine cancer was diagnosed. After the surgery, pathological examination revealed a uterine moderately differentiated adenocarcinoma of endometrioid subtype (subtype I according to Bokhman) deeply infiltrating the myometrium as well as the uterine cervix...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29920429/changes-in-sexuality-during-ulipristal-acetate-treatment-in-women-with-symptomatic-uterine-fibroids
#10
Benjamin Tuschy, Mirja Gabbert, Christel Weiss, Amadeus Hornemann, Anne Wuhrer, Marc Sütterlin, Sebastian Berlit
OBJECTIVE: To evaluate changes in sexuality in women treated with Ulipristal acetate (UPA) due to symptomatic uterine fibroids. STUDY DESIGN: A total of 102 women with symptomatic uterine fibroids undergoing conservative therapy with UPA were enrolled in this observational study. Sexuality was evaluated before and after a three month UPA treatment using the Female Sexual Functioning Index (FSFI) as well as the Sexual Activity Questionnaire (SAQ). Before treatment was initiated, participants additionally filled in a standardised questionnaire addressing the expected changes in sexuality due to UPA...
June 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29912292/oestrogen-fuels-the-growth-of-endometrial-hyperplastic-lesions-initiated-by-overactive-wnt-%C3%AE-catenin-signalling
#11
Jyoti Goad, Yi-An Ko, Manish Kumar, M Fairuz B Jamaluddin, Pradeep S Tanwar
Unopposed oestrogen results in approximately 80% of all the endometrial cancer patients. The relationship between unopposed oestrogen and endometrial cancer was indicated by the increase in the number of endometrial cancer cases due to the widespread use of oestrogen replacement therapy. Approximately 30% of the endometrial cancer patients have mutations in the Wnt signalling pathway. How the unbalanced ratios of ovarian hormones and the mutations in Wnt signalling pathway interact to cause endometrial cancer is currently unclear...
June 15, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29911998/hif2%C3%AE-in-the-uterine-stroma-permits-embryo-invasion-and-luminal-epithelium-detachment
#12
Leona Matsumoto, Yasushi Hirota, Tomoko Saito-Fujita, Norihiko Takeda, Tomoki Tanaka, Takehiro Hiraoka, Shun Akaeda, Hidetoshi Fujita, Ryoko Shimizu-Hirota, Shota Igaue, Mitsunori Matsuo, Hirofumi Haraguchi, Mayuko Saito-Kanatani, Tomoyuki Fujii, Yutaka Osuga
Although it has been reported that hypoxia inducible factor 2 α (Hif2a), a major transcriptional factor inducible by low oxygen tension, is expressed in the mouse uterus during embryo implantation, its role in pregnancy outcomes remains unclear. This study aimed to clarify functions of uterine HIF using transgenic mouse models. Mice with deletion of Hif2a in the whole uterus (Hif2a-uKO mice) showed infertility due to implantation failure. Supplementation with progesterone (P4) and leukemia inhibitory factor (LIF) restored decidual growth arrest and aberrant position of implantation sites in Hif2a-uKO mice, respectively, but did not rescue pregnancy failure...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29909704/the-effects-of-intravenous-dextrose-5-ringer-s-solution-and-oral-intake-on-the-duration-of-labor-stages-in-nulliparous-women-a-double-blind-randomized-controlled-trial
#13
Fatemeh Ahadi Yulghunlu, Fahimeh Sehhatie Shafaie, Mojgan Mirghafourvand, Hamideh Mohaddesi
BACKGROUND AND OBJECTIVES: Childbirth consists of a three stage period beginning with uterine contractions and ending in the expulsion of the placenta. The present study was conducted to compare the effects of Ringer's solution, dextrose solution 5% and oral intake on the duration of total labor and labor stages (primary outcome) and the frequency of oxytocin administration and prolonged labor (secondary outcome) in nulliparous women with spontaneous vaginal delivery. MATERIALS AND METHODS: The present randomized clinical trial was conducted on 201 nulliparous women in labor assigned with a randomized block design to three groups, each receiving either Ringer's solution plus oral fluids, dextrose solution 5% solution plus oral fluids or oral fluids alone...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29907759/bisphenol-a-exposure-during-early-pregnancy-impairs-uterine-spiral-artery-remodeling-and-provokes-intrauterine-growth-restriction-in-mice
#14
Judith Elisabeth Müller, Nicole Meyer, Clarisa Guillermina Santamaria, Anne Schumacher, Enrique Hugo Luque, Maria Laura Zenclussen, Horacio Adolfo Rodriguez, Ana Claudia Zenclussen
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy and possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating on placentation and uterine remodeling. We exposed pregnant female mice to 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from day 1 to 7 of gestation...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29904382/retinoic-acid-receptor-related-orphan-receptors-critical-roles-in-tumorigenesis
#15
REVIEW
Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting Ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin
Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis. Researches on RORs contributing to cancer-related processes have been growing, and they provide evidence that RORs are likely to be considered as potential therapeutic targets in many cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29904075/a-computational-model-of-excitation-and-contraction-in-uterine-myocytes-from-the-pregnant-rat
#16
Craig P Testrow, Arun V Holden, Anatoly Shmygol, Henggui Zhang
Aberrant uterine myometrial activities in humans are major health issues. However, the cellular and tissue mechanism(s) that maintain the uterine myometrium at rest during gestation, and that initiate and maintain long-lasting uterine contractions during delivery are incompletely understood. In this study we construct a computational model for describing the electrical activity (simple and complex action potentials), intracellular calcium dynamics and mechanical contractions of isolated uterine myocytes from the pregnant rat...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902983/health-providers-pass-knowledge-and-abilities-acquired-by-training-in-obstetric-emergencies-to-their-peers-the-average-treatment-on-the-treated-effect-of-pronto-on-delivery-attendance-in-mexico
#17
Jimena Fritz, Héctor Lamadrid-Figueroa, Gustavo Angeles, Alejandra Montoya, Dilys Walker
BACKGROUND: A significant proportion of newborn and maternal deaths can be prevented through simple and cost-effective strategies. The main aim of this study was to evaluate the impact of the PRONTO obstetric-emergency management training for improving evidence-based birth attendance practices among providers attending the training at 12 hospitals in three states of Mexico from 2010 to 2012, and to estimate dissemination of the training within the hospitals. METHODS: The average treatment on the treated effect of the PRONTO intervention for the probability of performing certain practices during birth attendance was estimated in a sample of 310 health providers...
June 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29901777/uterine-tppp3-plays-important-role-in-embryo-implantation-via-modulation-of-%C3%AE-catenin
#18
Vinay Shukla, Pooja Popli, Jyoti Bala Kaushal, Kanchan Gupta, Anila Dwivedi
Tubulin polymerization promoting protein 3 (TPPP3) is known to be expressed in the endometrium in a cyclic manner, its functional role in the physiology of implantation remains unknown. Here we demonstrate a novel function of TPPP3 during the window of implantation and in the establishment of pregnancy using a mouse model. The increased protein expression of TPPP3 and β-catenin during peri-implantation period i.e. D5 (receptive phase, 0800 h) was observed as compared to that on D1 (non-receptive phase, 0800 h)...
June 12, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29899331/placental-exosome-mediated-bta-mir-499-lin28b-let-7-axis-regulates-inflammatory-bias-during-early-pregnancy
#19
Gan Zhao, Chao Yang, Jing Yang, Pei Liu, Kangfeng Jiang, Aftab Shaukat, Haichong Wu, Ganzhen Deng
Abnormal inflammatory bias in the maternal-fetal interface leads to reproductive failure in mammals. Placental exosomes are involved in maternal-fetal communication during pregnancy. However, whether the placenta or fetus is involved in regulating the balance of uterine local inflammation through exosomes remains unclear, and the mechanism must be further explored. Here we demonstrated that placenta-specific exosomes are abundant in the peripheral blood of dairy cows during early pregnancy and selectively load miRNAs, such as bta-miR-499...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29898442/a-novel-early-pregnancy-risk-prediction-model-for-gestational-diabetes-mellitus
#20
Arianne N Sweeting, Jencia Wong, Heidi Appelblom, Glynis P Ross, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
INTRODUCTION: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated novel biomarker predictors to develop a first-trimester risk prediction model in a large multiethnic cohort. METHODS: Maternal clinical, aneuploidy and pre-eclampsia screening markers (PAPP-A, free hCGβ, mean arterial pressure, uterine artery pulsatility index) were measured prospectively at 11-13+6 weeks' gestation in 980 women (248 with GDM; 732 controls)...
June 13, 2018: Fetal Diagnosis and Therapy
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