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https://www.readbyqxmd.com/read/29055044/anti-glypican-1-antibody-drug-conjugate-exhibits-potent-preclinical-antitumor-activity-against-glypican-1-positive-uterine-cervical-cancer
#1
Satoko Matsuzaki, Satoshi Serada, Kosuke Hiramatsu, Satoshi Nojima, Shinya Matsuzaki, Yutaka Ueda, Tomoharu Ohkawara, Seiji Mabuchi, Minoru Fujimoto, Eiichi Morii, Kiyoshi Yoshino, Tadashi Kimura, Tetsuji Naka
Glypican-1 (GPC1) is highly expressed in solid tumors, especially squamous cell carcinomas (SCCs), and is thought to be associated with disease progression. We explored the use of a GPC1-targeted antibody-drug conjugate (ADC) as a novel treatment for uterine cervical cancer. On immunohistochemical staining, high expression levels of GPC1 were detected in about 50% of uterine cervical cancer tissues and also in a tumor that had relapsed after chemoradiotherapy. Novel anti-GPC1 monoclonal antibodies were developed, and clone 01a033 was selected as the best antibody for targeted delivery of the cytotoxic agent monomethyl auristatin F (MMAF) into GPC1-positive cells...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29054502/epidemiology-and-risk-factors-of-uterine-fibroids
#2
REVIEW
Dora Pavone, Sara Clemenza, Flavia Sorbi, Massimiliano Fambrini, Felice Petraglia
Risk factors, both modifiable and non-modifiable, are associated with the development of fibroids. These include age, race, endogenous and exogenous hormonal factors, obesity, uterine infection, and lifestyle (diet, caffeine and alcohol consumption, physical activity, stress, and smoking). Some of the epidemiological data were conflicting; consequently, further studies are needed to better understand the factors that influence fibroid prevalence.
October 1, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29052004/hypoxia-regulated-catecholamine-secretion-in-chromaffin-cells
#3
REVIEW
Colin A Nurse, Shaima Salman, Angela L Scott
Adrenal catecholamine (CAT) secretion is a general physiological response of animals to environmental stressors such as hypoxia. This represents an important adaptive mechanism to maintain homeostasis and protect vital organs such as the brain. In adult mammals, CAT secretory responses are triggered by activation of the sympathetic nervous system that supplies cholinergic innervation of adrenomedullary chromaffin cells (AMC) via the splanchnic nerve. In the neonate, the splanchnic innervation of AMC is immature or absent, yet hypoxia stimulates a non-neurogenic CAT secretion that is critical for adaptation to extra-uterine life...
October 19, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29050963/long-chain-glucosylceramides-crosstalk-with-lyn-mediates-endometrial-cell-migration
#4
Dulani Wimalachandra, Joan Yang Xiaohui, Lina Zhu, Evan Tan, Harry Asada, Jerry Y K Chan, Yie Hou Lee
Endometriosis is a disease characterized by regurgitated lesions which are invasive and migratory, embedding at ectopic, extra-uterine locations. Extracellular glucosylceramides (GlcCers), bioactive sphingolipids potentiating signals for cell migration, are found in elevated levels in endometriosis; however underlying mechanisms that result in cellular migration are poorly defined. Here, we demonstrated that internalized GlcCer induced migratory activity in immortalized human endometrial stromal cells (HESCs), with highest potency observed in long-chain GlcCer...
October 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29043101/protective-effect-of-rhus-verniciflua-stokes-extract-in-an-experimental-model-of-post-menopausal-osteoporosis
#5
Ji Heun Jeong, Jong Hoon An, Hui Yang, Do-Kyung Kim, Nam-Seob Lee, Young-Gil Jeong, Chun Soo Na, Dae Seung Na, Mi-Sook Dong, Seung Yun Han
Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor-binding affinities...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042488/natural-killer-cells-mediate-pathophysiology-in-response-to-reduced-uterine-perfusion-pressure
#6
Jamil Elfarra, Lorena M Amaral, Maggie McCalmon, Jeremy D Scott, Mark W Cunningham, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C Cornelius
Preeclampsia is associated with hypertension, small-for-gestational-age babies and increased cytolytic natural killer (NK) cells. The specific role of cytolytic NK cells in the pathophysiology of preeclampsia has not been clearly defined. We hypothesized that Reduced Uterine Perfusion Pressure (RUPP) stimulates proliferation and cytolytic activation of NK cells, and that reducing NK cells in RUPP would prevent hypertension, intrauterine growth restriction, and inflammation in response to placental ischemia...
October 17, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#7
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
September 27, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29037554/the-role-of-resveratrol-on-full-thickness-uterine-wound-healing-in-rats
#8
Oya Sayin, Serap Cilaker Micili, Asli Goker, Gonca Kamaci, Bekir Ugur Ergur, Osman Yilmaz, Gul Guner Akdogan
OBJECTIVE: Healing of the uterus after cesarean section and myomectomy operation is clinically important. In this study, we aimed to investigate the effects of resveratrol (3,5,4'-o-trihydroxystilbene) on the wound healing process of the uterus in rats treated with resveratrol following full thickness injury of the uterus. MATERIALS AND METHODS: Twenty-one female wistar albino rats were divided randomly into three groups (1) control group with no intervention (2) injury group with uterine full thickness injury (3) resveratrol group with uterine full thickness injury and treated with resveratrol...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29036279/strong-inhibition-of-neutrophil-sperm-interaction-in-cattle-by-selective-pi3-kinase-inhibitors
#9
Jiwon Hong, Bridget L Dicker, Shakeela N Jayasinghe, Francesca De Gregorio, Hong Tian, Dug Yeo Han, Keith R Hudson
The vast majority of sperm are lost from the female reproductive tract in hours following natural mating or artificial insemination in mammals. Multiple complex processes including uterine contractions, mucus barriers and phagocytosis of sperm by neutrophils have been reported to be involved in the sperm loss, although the contribution of each process is uncertain. If phagocytosis by neutrophils has a significant role in sperm loss, inhibition of neutrophil response to sperm could potentially reduce the dose of sperm required for artificial insemination...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29036275/porcupine-dependent-wnt-activity-within-the-uterine-epithelium-is-essential-for-fertility
#10
Omar Farah, Steffen Biechele, Janet Rossant, Daniel Dufort
The secretion of mammalian Wnt ligands within the cell is dependent on the activity of Porcupine, a gene located on the X-chromosome that encodes for a membrane bound o-acyl transferase. Here, we report that post-natal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number. Despite having uterine glands, mutant females are completely infertile. Epithelial ablation of Porcupine causes defects in timely apposition of the lumen, along with failure to respond to artificial decidual induction...
October 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29035998/uterine-metastasis-from-gastric-adenocarcinoma-masquerading-as-physiologic-endometrial-uptake-in-fdg-pet-ct
#11
Yutang Yao, Minggang Su, Xiaohong Ou, Yangmei Shen
A 44-year-old woman with newly diagnosed gastric adenocarcinoma by gastroscopy underwent F-FDG PET/CT to evaluate possible metastasis. The images demonstrated intense activity in the region of uterine corpus, as well as greater gastric curvature. Physiologic uptake of endometrium was initially suspected, given the rarity with which extragenital cancers metastasize to the uterus. Ultimately, the endometrium proved to be mucinous adenocarcinoma of gastric origin based on its shared histological features and compatible immunostaining profile...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29033994/effect-of-dates-in-late-pregnancy-on-the-duration-of-labor-in-nulliparous-women
#12
Masoumeh Kordi, Fatemeh Aghaei Meybodi, Fatemeh Tara, Farzaneh Rashidi Fakari, Mohsen Nemati, Mohammadtaghi Shakeri
BACKGROUND: Long-term delivery is an important significant issue which is associated with mortality and fetal and maternal disorders. Based on the previous studies, consumption of dates affects uterine contractions and duration of delivery processes. This study aimed to study the effect of date consumption in late pregnancy on the duration of delivery processes in nulliparous women in 2013. MATERIALS AND METHODS: This randomized clinical trial was conducted among 182 nulliparous women 18-35 years who presented to OmAlBanin Hospital in Mashhad in 2013...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29025848/ectopic-pregnancy-exploration-of-its-global-research-architecture-using-density-equalising-mapping-and-socioeconomic-benchmarks
#13
Dörthe Brüggmann, Jana Kollascheck, David Quarcoo, Michael H Bendels, Doris Klingelhöfer, Frank Louwen, Jenny M Jaque, David A Groneberg
OBJECTIVE: About 2% of all pregnancies are complicated by the implantation of the zygote outside the uterine cavity and termed ectopic pregnancy. Whereas a multitude of guidelines exists and related research is constantly growing, no thorough assessment of the global research architecture has been performed yet. Hence, we aim to assess the associated scientific activities in relation to geographical and chronological developments, existing research networks and socioeconomic parameters...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29023770/c-c-motif-chemokine-ligand-23-abolishes-er-stress-and-lps-induced-reduction-in-proliferation-of-bovine-endometrial-epithelial-cells
#14
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
To reduce embryonic losses in domestic animals for economic production of livestock meat and milk, chemokines and their receptors are required for proper implantation and placentation during early pregnancy. In this study, we investigated the effects of C-C-motif chemokine ligand 23 (CCL23) on the proliferation of bovine endometrial (BEND) epithelial cells. CCL23 treatment improved BEND cell proliferation by enhancing PCNA and cyclin D1 expression via activation of the PI3K/AKT and MAPK signaling pathways. In addition, a combination of CCL23 and tunicamycin reversed the ER stress-induced reduction in cell proliferation and the decreased expression of UPR-mediated signaling proteins, including IRE1α, PERK, and ATF6α...
October 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29023592/polymer-based-precipitation-preserves-biological-activities-of-extracellular-vesicles-from-an-endometrial-cell-line
#15
Ziru Niu, Ronald T K Pang, Weimin Liu, Qian Li, Ranran Cheng, William S B Yeung
Extracellular vesicles (EVs) are membrane-bound vesicles released by cells and act as media for transfer of proteins, small RNAs and mRNAs to distant sites. They can be isolated by different methods. However, the biological activities of the purified EVs have seldom been studied. In this study, we compared the use of ultracentrifugation (UC), ultra-filtration (UF), polymer-based precipitation (PBP), and PBP with size-based purification (PBP+SP) for isolation of EVs from human endometrial cells and mouse uterine luminal fluid (ULF)...
2017: PloS One
https://www.readbyqxmd.com/read/29020039/er%C3%AE-36-a-variant-of-estrogen-receptor-%C3%AE-is-predominantly-localized-in-mitochondria-of-human-uterine-smooth-muscle-and-leiomyoma-cells
#16
Yitang Yan, Linda Yu, Lysandra Castro, Darlene Dixon
ERα36 is a naturally occurring, membrane-associated, isoform of estrogen receptor α. The expression of ERα36 is due to alternative splicing and different promoter usage. ERα36 is a dominant-negative effector of ERα66-mediated transactivational activities and has the potential to trigger membrane-initiated mitogenic, nongenomic, estrogen signaling; however, the subcellular localization of ERα36 remains controversial. To determine the cellular localization of ERα36 in estrogen-responsive human uterine smooth muscle (ht-UtSMC) and leiomyoma (fibroid; ht-UtLM) cells, we conducted systematic confocal microscopy and subcellular fractionation analysis using ERα36 antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/29016497/discontinuing-oxytocin-infusion-in-the-active-phase-of-labor-a-systematic-review-and-meta-analysis
#17
Gabriele Saccone, Andrea Ciardulli, Jason K Baxter, Joanne N Quiñones, Liany C Diven, Bor Pinar, Giuseppe Maria Maruotti, Pasquale Martinelli, Vincenzo Berghella
OBJECTIVE: To evaluate the benefits and harms of discontinuation of oxytocin after the active phase of labor is reached. DATA SOURCES: Electronic databases (ie, MEDLINE, Scopus, ClinicalTrials.gov, EMBASE, ScienceDirect, the Cochrane Library at the CENTRAL Register of Controlled Trials, Scielo) were searched from their inception until April 2017. METHODS OF STUDY SELECTION: We included all randomized controlled trials comparing discontinuation (ie, intervention group) and continuation (ie, control group) of oxytocin infusion after the active phase of labor is reached, either after induction or augmentation of labor...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28994515/role-of-pelvic-ultrasound-simulation
#18
Sushila Arya, Zuber D Mulla, Sanja Kupesic Plavsic
BACKGROUND: Pelvic ultrasound is a critical diagnostic imaging tool in obstetrics and gynaecology. Training opportunities in transvaginal ultrasound have not kept pace with the demand among learners because of the increased complexity of modern ultrasound technology and duty-hour restrictions. Ultrasound simulation training has the potential to overcome this gap. Training opportunities in transvaginal ultrasound have not kept pace with the demand OBJECTIVE: Our study aimed to determine the usefulness, applicability and attitudes toward pelvic ultrasound simulation training among residents, sonographers and practising doctors...
October 10, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28994024/association-of-vitamin-b12-lactate-dehydrogenase-and-regulation-of-nf-%C3%AE%C2%BAb-in-the-mitigation-of-sodium-arsenite-induced-ros-generation-in-uterine-tissue-by-commercially-available-probiotics
#19
Sandip Chattopadhyay, Shamima Khatun, Moulima Maity, Suryashis Jana, Hasina Perveen, Moumita Dash, Arindam Dey, Lipi Rani Jana, Pikash Pratim Maity
Managing arsenic intoxication with conventional metal chelators is a global challenge. The present study demonstrated the therapeutic role of probiotics against arsenic-induced oxidative stress and female reproductive dysfunction. Sodium arsenite-treated (1.0 mg/100 g body weight) Wistar female rats were followed up by a post-treatment of commercially available probiotic mixture in powder form (0.25 mg/100 g body weight) orally. Rats that experienced arsenic ingestion showed a significant lessening in the activities of uterine superoxide dismutase (SOD), catalase activities, and the level of non-protein soluble thiol (NPSH) with a concomitant increase in malondialdehyde (MDA) and conjugated dienes (CD)...
October 9, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28993394/recruitment-adherence-and-retention-of-endometrial-cancer-survivors-in-a-behavioural-lifestyle-programme-the-diet-and-exercise-in-uterine-cancer-survivors-deus-parallel-randomised-pilot-trial
#20
Dimitrios A Koutoukidis, Rebecca J Beeken, Ranjit Manchanda, Moscho Michalopoulou, Matthew Burnell, M Tish Knobf, Anne Lanceley
OBJECTIVE: Healthy eating and physical activity may help endometrial cancer survivors (ECS) improve their quality of life. However, most ECS do not meet the relevant guidelines. This pilot trial aimed to test the study feasibility procedures for a definitive trial of a behavioural lifestyle programme. DESIGN AND SETTING: This 24-week parallel two-arm randomised pilot trial took place in two hospitals in London, UK (April 2015-June 2016). PARTICIPANTS: Sixty disease-free ECS within 3 years of diagnosis...
October 8, 2017: BMJ Open
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