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https://www.readbyqxmd.com/read/29237804/inhibiting-nuclear-phospho-progesterone-receptor-enhances-antitumor-activity-of-onapristone-in-uterine-cancer
#1
Yan Huang, Wei Hu, Jie Huang, Fanrong Shen, Yunjie Sun, Cristina Ivan, Sunila Pradeep, Robert Dood, Monika Haemmerle, Dahai Jiang, Lingegowda S Mangala, Kyunghee Noh, Jean M Hansen, Heather J Dalton, Rebecca Previs, Archana S Nagaraja, Michael McGuire, Nicholas B Jennings, Russell R Broaddus, Robert L Coleman, Anil K Sood
While progesterone receptor (PR)-targeted therapies are modestly active in patients with uterine cancer, their underlying molecular mechanisms are not well understood. The clinical use of such therapies is limited because of the lack of biomarkers that predict response to PR-agonists (progestins) or PR-antagonists (onapristone). Thus, understanding the underlying molecular mechanisms of action will provide an advance in developing novel combination therapies for cancer patients. Nuclear translocation of PR has been reported to be ligand-dependent or -independent...
December 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29234102/endometrial-apoptosis-and-neutrophil-infiltration-during-menstruation-exhibits-spatial-and-temporal-dynamics-that-are-recapitulated-in-a-mouse-model
#2
Gregory M Armstrong, Jacqueline A Maybin, Alison A Murray, Moira Nicol, Catherine Walker, Philippa T K Saunders, Adriano G Rossi, Hilary O D Critchley
Menstruation is characterised by synchronous shedding and restoration of tissue integrity. An in vivo model of menstruation is required to investigate mechanisms responsible for regulation of menstrual physiology and to investigate common pathologies such as heavy menstrual bleeding (HMB). We hypothesised that our mouse model of simulated menstruation would recapitulate the spatial and temporal changes in the inflammatory microenvironment of human menses. Three regulatory events were investigated: cell death (apoptosis), neutrophil influx and cytokine/chemokine expression...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29230527/lefty2-inhibits-endometrial-receptivity-by-downregulating-orai1-expression-and-store-operated-ca2-entry
#3
Madhuri S Salker, Yogesh Singh, Ruban R Peter Durairaj, Jing Yan, Md Alauddin, Ni Zeng, Jennifer H Steel, Shaqiu Zhang, Jaya Nautiyal, Zoe Webster, Sara Y Brucker, Diethelm Wallwiener, B Anne Croy, Jan J Brosens, Florian Lang
Early embryo development and endometrial differentiation are initially independent processes, and synchronization, imposed by a limited window of implantation, is critical for reproductive success. A putative negative regulator of endometrial receptivity is LEFTY2, a member of the transforming growth factor (TGF)-β family. LEFTY2 is highly expressed in decidualizing human endometrial stromal cells (HESCs) during the late luteal phase of the menstrual cycle, coinciding with the closure of the window of implantation...
December 11, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29230415/hypoxia-induces-apoptosis-through-hif-1%C3%AE-signaling-pathway-in-human-uterosacral-ligaments-of-pelvic-organ-prolapse
#4
Xinrui Zhao, Congcong Ma, Rui Li, Jing Xue, Lidong Liu, Peishu Liu
The purpose of this study is to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) in women uterosacral ligament tissues with pelvic organ prolapse and women with normal uterine support structures and illuminate its relationship with apoptosis. Samples were collected from 38 women with pelvic organ prolapse and 31 age matched controls. The expression levels of HIF-1α and BNIP3 in the uterosacral ligaments were measured using immunohistochemistry, qRT-PCR, and Western blot. To assess apoptosis we performed TUNEL assay and Western blot analyses...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29229922/comparison-of-electrohysterogram-signal-measured-by-surface-electrodes-with-different-designs-a-computational-study-with-dipole-band-and-abdomen-models
#5
Pei Gao, Dongmei Hao, Yang An, Ying Wang, Qian Qiu, Lin Yang, Yimin Yang, Song Zhang, Xuwen Li, Dingchang Zheng
Non-invasive measurement of uterine activity using electrohysterogram (EHG) surface electrodes has been attempted to monitor uterine contraction. This study aimed to computationally compare the performance of acquiring EHG signals using monopolar electrode and three types of Laplacian concentric ring electrodes (bipolar, quasi-bipolar and tri-polar). With the implementation of dipole band model and abdomen model, the performances of four electrodes in terms of the local sensitivity were quantified by potential attenuation...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227245/clearance-of-senescent-decidual-cells-by-uterine-natural-killer-cells-in-cycling-human-endometrium
#6
Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan Joris Brosens
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit and differentiation into decidual cells that control embryo implantation. Here we show that FOXO1 also causes acute senescence of a subpopulation of decidualizing EnSCs in an IL-8 dependent manner. Selective depletion or enrichment of this subpopulation revealed that decidual senescence drives the transient inflammatory response associated with endometrial receptivity...
December 11, 2017: ELife
https://www.readbyqxmd.com/read/29217922/effect-of-solanum-nigrun-on-uterus-of-non-gravid-rats
#7
Freddy O Agoreyo, B Rita Ohimai, Magdalene I Omigie
Background: Solanum nigrum is a widely used plant in oriental medicine where it is considered to be antioxidant, anti- inflammatory and diuretic. This study aimed to evaluate the effect of Solanum Nigrum on uterine contractions. Method: Female Wistar Wister albino rats were used for the study. They were housed in a single large cage in an atmospheric controlled environment. Twenty-four hours before every experiment, 0.2 mg/kg of diethylstilbesterol constituted in 1:1 ethanol/water solution, was administered intraperitoneally as a pre-treatment to the rats to induce oestrus...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217487/genistein-and-daidzein-treatments-differently-affect-uterine-homeostasis-in-the-ovary-intact-middle-aged-rats
#8
Ivana Jarić, Jasmina Živanović, Marko Miler, Vladimir Ajdžanović, Duško Blagojević, Nataša Ristić, Verica Milošević, Nataša Nestorović
This study aimed to investigate the effects of soy isoflavones, genistein (GEN) and daidzein, (DAI) on the uterine function in ovary-intact middle-aged rats. GEN and DAI (35mg/kg) were subcutaneously administrated to acyclic (12-month-old) Wistar females, daily, for 4weeks. Control group received either vehicle (olive oil and ethanol, 9:1) or remained intact. We found that GEN and DAI differently affect uterine morphophysiology. GEN significantly increased the uterine wet weight which was associated with hyperplastic changes, revealed by stereological and histomorphometrical analyses...
December 5, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29216626/evidence-for-hmgn2-involvement-in-mouse-embryo-implantation-and-decidualization
#9
Dang-Dang Li, Liang Yue, Zhan-Qing Yang, Lian-Wen Zheng, Bin Guo
BACKGROUND/AIMS: Hmgn2 is involved in regulating embryonic development, but its physiological function during embryo implantation and decidualization remains unknown. METHODS: In situ hybridization, real-time PCR, RNA interference, gene overexpression and MTS assay were used to examine the expression of Hmgn2 in mouse uterus during the pre-implantation period and explore its function and regulatory mechanisms in epithelial adhesion junction and stromal cell proliferation and differentiation...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29215514/misoprostol-with-foley-bulb-compared-with-misoprostol-alone-for-cervical-ripening-a-randomized-controlled-trial
#10
Zainab Al-Ibraheemi, Lois Brustman, Brianne E Bimson, Natalie Porat, Barak Rosenn
OBJECTIVE: To test the hypothesis that cervical ripening using a combination of misoprostol and a transcervical Foley bulb leads to delivery within a shorter time compared with misoprostol alone. METHODS: This randomized controlled trial was offered to women admitted for cervical ripening. Inclusion criteria were gestational age 37 weeks or greater with intact membranes, singleton fetus, cephalic presentation, and Bishop score 6 or less. Exclusion criteria included, among others, prior uterine surgery, ruptured membranes, and any contraindication to vaginal delivery...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29211492/incidence-and-burden-of-gynecologic-disorders-active-component-service-women-u-s-armed-forces-2012-2016
#11
Shauna Stahlman, Valerie F Williams, Stephen B Taubman
This report describes the incidence, burden, and co-occurrence of four common gynecologic disorders among active component service women during 2012-2016. Overall incidence rates were highest for menorrhagia (100.9 per 10,000 person-years [p-yrs]), followed by uterine fibroids (63.2 per 10,000 p-yrs), endometriosis (30.8 per 10,000 p-yrs), and polycystic ovary syndrome (PCOS, 25.3 per 10,000 p-yrs). Annual incidence rates and medical encounters for menorrhagia decreased by roughly 50% from 2012 through 2015, and then increased slightly in 2016...
November 2017: MSMR
https://www.readbyqxmd.com/read/29211326/recent-work-supports-the-concept-of-an-active-sphincter-in-the-uterine-cervix
#12
Helen Feltovich, Joy-Sarah Vink
In this issue, Nott et al. qualitatively and quantitatively investigate the architecture of the cervix in ex vivo nonpregnant human samples. Using Diffusion Tensor MRI and a fiber tracking algorithm, they identify an outer circular and inner longitudinal layer of fibers throughout the cervix. Quantitative measurements of diffusion, tract orientation and volume confirm that the outer circumferential band of fibers is particularly dense and uniform in the proximal cervix, at the region of the internal os. This article is protected by copyright...
December 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29208689/gestation-changes-sodium-pump-isoform-expression-leading-to-changes-in-ouabain-sensitivity-contractility-and-intracellular-calcium-in-rat-uterus
#13
Rachel V Floyd, Ali Mobasheri, Susan Wray
Developmental and tissue-specific differences in isoforms allow Na+, K+-ATPase function to be tightly regulated, as they control sensitivity to ions and inhibitors. Uterine contraction relies on the activity of the Na+, K+ATPase, which creates ionic gradients that drive excitation-contraction coupling. It is unknown whether Na+, K+ATPase isoforms are regulated throughout pregnancy or whether they have a direct role in modulating uterine contractility. We hypothesized that gestation-dependent differential expression of isoforms would affect contractile responses to Na+, K+ATPase α subunit inhibition with ouabain...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29208367/the-role-of-epcam-in-tumor-progression-and-the-clinical-prognosis-of-endometrial-carcinoma
#14
Kuo-Chang Wen, Pi-Lin Sung, Yu-Ting Chou, Chih-Ming Pan, Peng-Hui Wang, Oscar Kuang-Sheng Lee, Cheng-Wen Wu
OBJECTIVE: EpCAM is a transmembrane glycoprotein that functions as an epithelial marker in endometrial tissues. However, the correlation between EpCAM and endometrial carcinoma (EC) is not clear. METHODS: This study investigated the association between EpCAM and EC. Immunohistochemistry staining and bioinformatics analysis disclosed the clinical importance of low EpCAM expression. The migratory ability of cells expressing low EpCAM levels was studied in transwell invasion assays in vitro and an orthotopic intra-uterine tumor injection model in vivo...
December 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29207994/the-functional-and-molecular-studies-on-involvement-of-hydrogen-sulphide-in-myometrial-activity-of-non-pregnant-buffaloes-bubalus-bubalis
#15
Sooraj V Nair, Vipin Sharma, Abhishek Sharma, Udayraj P Nakade, Pooja Jaitley, Karikalan Mathesh, Soumen Choudhury, Satish Kumar Garg
BACKGROUND: Hydrogen sulphide (H2S), a member of the gasotransmitters family, is known to play patho-physiological role in different body systems including during pregnancy. But its involvement in myometrial spontaneity and associated signalling pathways in uterus in non-pregnant animals is yet to be studied. Present study describes the effect of L-cysteine, an endogenous H2S donor, on isolated myometrial strips of non-pregnant buffaloes and the underlying signaling mechanism(s). RESULTS: L-cysteine (10 nM-30 mM) produced concentration-dependent contractile effect on buffalo myometrium which was extracellular Ca2+ and L-type calcium channels-dependent...
December 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29202469/h3k27me3-dynamics-dictate-evolving-uterine-states-in-pregnancy-and-parturition
#16
Patrice Nancy, Johan Siewiera, Gabrielle Rizzuto, Elisa Tagliani, Ivan Osokine, Priyanka Manandhar, Igor Dolgalev, Caterina Clementi, Aristotelis Tsirigos, Adrian Erlebacher
Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a noncontractile state until term and then surmounts this state to enter labor. Here, we show that dynamic generation and erasure of the repressive histone modification tri-methyl histone H3 lysine 27 (H3K27me3) in decidual stromal cells dictate both elements of pregnancy success in mice. In early gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiescence by preventing the decidua from expressing parturition-inducing hormone receptors, manifesting type 1 immunity, and most unexpectedly, generating myofibroblasts and associated wound-healing responses...
November 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29202392/serial-hcg-and-progesterone-levels-to-predict-early-pregnancy-outcomes-in-pregnancies-of-uncertain-viability-a-prospective-study
#17
Claire Puget, Yolaine Joueidi, Estelle Bauville, Bruno Laviolle, Claude Bendavid, Vincent Lavoué, Maela Le Lous
OBJECTIVE: To assess the value of serial hCG and progesterone serum level in the diagnosis of early pregnancy viability. METHODS: It was a prospective cohort study. Women with a pregnancy of uncertain viability (PUV), defined as the presence of an intra-uterine embryo with a crown-rump length <7mm with no cardiac activity or an intra-uterine gestational sac size <25mm with no visible embryonic structure in a transvaginal ultrasound scan (TVS) were eligible...
December 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29200103/bcor-internal-tandem-duplication-in-high-grade-uterine-sarcomas
#18
Adrián Mariño-Enriquez, Alexandra Lauria, Joanna Przybyl, Tony L Ng, Magdalena Kowalewska, Maria Debiec-Rychter, Raji Ganesan, Vaiyapuri Sumathi, Suzanne George, W Glenn McCluggage, Marisa R Nucci, Cheng-Han Lee, Jonathan A Fletcher
Endometrial stromal sarcomas (ESSs) are mesenchymal uterine tumors characterized by recurrent genetic events, most commonly chromosomal rearrangements, that create oncogenic gene fusions. High-grade endometrial stromal sarcomas (HG-ESSs), as defined in the 2014 World Health Organization Classification, typically contain oncogenic YWHAE-NUTM2 fusions; however, although not well characterized, there are tumors morphologically overlapping with HG-ESS that do not contain the YWHAE-NUTM2 fusions. These fusions are also found in certain pediatric primitive sarcomas, including clear cell sarcoma of the kidney and soft tissue undifferentiated round cell sarcoma of infancy...
December 1, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29199729/epidemiology-of-gynecological-cancers-in-kamrup-urban-district-cancer-registry
#19
D Barman, J D Sharma, D Barmon, A C Kataki, A Sharma, M Kalita
BACKGROUND: Cancers of the female reproductive system - namely cancer of the cervix, corpus uteri, ovarian, vulvar, vaginal, fallopian tube cancers and choriocarcinoma are an important cause of cancer morbidity and mortality among women worldwide. It is estimated to be the third most common group of malignancies in women. The comprehensive global cancer statistics from the International Agency for Research on Cancer indicate that gynaecological cancers accounted for 20% of the 14.1 million estimated new cancer cases and 8...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198424/the-uterine-fibroid-myoma-tumour-analysis-of-the-global-research-architecture-using-density-equalizing-mapping
#20
Dörthe Brüggmann, Frank Louwen, Tatjana Braun, Doris Klingelhöfer, Jan Bauer, Michael H Bendels, Matthias Bundschuh, David Quarcoo, Jenny Jaque, Eileen M Wanke, David A Groneberg
Uterine fibroids can severely impact a woman's quality of life, result in significant morbidity and are a leading indication for hysterectomy. Many aspects of the disease remain largely obscure. Despite these knowledge gaps, no detailed maps of the global fibroid research architecture have yet been generated. This study used the NewQIS approach to assess worldwide research productivity, encompassing numerous aspects of the scientific output, quality and socioeconomic features. Regression analysis indicated an increase in fibroid research activity in the investigated time periods...
November 15, 2017: Reproductive Biomedicine Online
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