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Amyloidosis

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https://www.readbyqxmd.com/read/29328013/-a-woman-with-a-painful-and-enlarged-tongue
#1
B P van Lieshout, K H Karagozoglu, E A J M Schulten
A 53-year-old woman presented with painful macroglossia and periorbital papules. Based on this clinical features and biopsies the diagnosis of nodular amyloidosis was established. Further analysis revealed that multiple myeloma was the underlying hematological disorder.
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29327051/primary-orbital-amyloidosis
#2
Manpreet Singh, Kolavali Raghavendra Rao, Ashim Das
No abstract text is available yet for this article.
January 11, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29321803/the-eyes-are-the-window-to-the-heart-one-case-of-cardiac-amyloidosis-with-eyelid-swelling-as-the-initial-symptom
#3
Ting-Zhi Deng, Bai-Qing Ou, Dao-Quan Peng
No abstract text is available yet for this article.
November 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29321425/elevation-of-plasmin-%C3%AE-2-plasmin-inhibitor-complexes-in-patients-with-al-amyloidosis
#4
Kanji Miyazaki, Kenshi Suzuki
No abstract text is available yet for this article.
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29321198/hepatic-amyloidosis-a-cause-of-rapidly-progressive-jaundice
#5
Mark Ford, Benjamin Disney, Veena Shinde, Sauid Ishaq
No abstract text is available yet for this article.
January 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29319549/tongue-indentations-secondary-to-light-chain-amyloidosis
#6
Carlos Antonio Moura, Pedro Herrera, Janine Magalhães, Carlos Geraldo Moura
No abstract text is available yet for this article.
January 9, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29319281/yellow-teardrop-like-structures-in-primary-nodular-skin-amyloidosis
#7
Nicola DI Meo, Cecilia Noal, Mattia Fadel, Giusto Trevisan
No abstract text is available yet for this article.
February 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29319035/a-rare-case-of-bronchial-elastosis-an-unusual-presentation-of-an-unexpandable-lung
#8
Raghav Gupta, Hassan Patail, Mohammad R Al-Ajam
Endobronchial obstruction is a known cause of an unexpandable lung. Endobronchial lesions are usually malignant, however benign cause like hemartoma, lipoma, amyloidosis and neuroendocrine tumors are known. We, hereby present the rare cause of bronchial elastosis presenting as right lower lobe lung collapse.
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29316245/flow-cytometric-aberrancies-in-plasma-cell-myeloma-and-mgus-correlation-with-laboratory-parameters
#9
Sarika Gupta, Nitin J Karandikar, Timothy Ginader, Andrew M Bellizzi, Carol J Holman
BACKGROUND: Multiparametric flow cytometry (MFC) is a useful tool for diagnosis of plasma cell dyscrasias and assessment of minimal residual disease (MRD) in plasma cell myeloma (PCM). However, the immunophenotypic differences between the clonal plasma cells (PCs) of plasma cell myeloma (PCM) and those of monoclonal gammopathy of undetermined significance (MGUS) as well as the correlation of these flow cytometric markers with pertinent laboratory parameters have not been evaluated. METHODS: We retrospectively identified all newly diagnosed treatment-naive PCM and MGUS patients between 09/2014 and 06/2015 who underwent 10-color flow-cytometric evaluation: CD45, CD38, CD138, cKappa, cLambda, CD19, CD27, CD28, CD56, CD117...
January 6, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29314707/comparison-of-early-versus-late-onset-familial-mediterranean-fever
#10
Nazife Sule Yasar Bilge, Ismail Sari, Dilek Solmaz, Soner Senel, Hakan Emmungil, Levent Kilic, Sibel Yilmaz Oner, Fatih Yildiz, Sedat Yilmaz, Duygu Ersozlu Bozkirli, Muge Aydin Tufan, Sema Yilmaz, Veli Yazisiz, Yavuz Pehlivan, Cemal Bes, Gozde Yildirim Cetin, Sukran Erten, Emel Gonullu, Fezan Sahin, Servet Akar, Kenan Aksu, Umut Kalyoncu, Haner Direskeneli, Eren Erken, Mehmet Sayarlioglu, Muhammed Cınar, Timucin Kasifoglu
AIM: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. One of the common characteristics of this disease is its young age predominance. Nearly 90% of patients experience disease flares during early adult age periods. Currently there are limited data for the comparison of early versus late onset FMF and therefore the primary aim of this study was to investigate these two subsets with regard to their certain demographic, clinical and genetic differences. METHODS: Early (≤ 20 years, Group 1) and late (> 20 years, Group 2) onset FMF patients were identified from the national FMF registry that involves 2246 patients from 15 adult rheumatology clinics located in different geographical areas of Turkey...
January 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29311044/multiple-myeloma-presenting-with-acquired-cutis-laxa-and-primary-systemic-amyloidosis
#11
Min Young Lee, Ji Yeon Byun, You Won Choi, Hae Young Choi
No abstract text is available yet for this article.
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29308670/late-iodine-enhancement-and-myocardial-extracellular-volume-quantification-in-cardiac-amyloidosis-by-using-dual-energy-cardiac-computed-tomography-performed-on-a-dual-layer-spectral-detector-scanner
#12
Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Kyoko Hirakawa, Seiji Takashio, Yasuhiro Izumiya, Kenichi Tsujita, Hiroyuki Hata, Yukio Ando, Yasuyuki Yamashita
No abstract text is available yet for this article.
January 8, 2018: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/29307226/new-concepts-in-the-treatment-and-diagnosis-of-amyloidosis
#13
Paolo Milani, Giovanni Palladini, Giampaolo Merlini
The most common form of systemic amyloidosis in Western countries is light chain amyloidosis. It is characterized by the deposition of a misfolded light chain in target organs. This amyloid precursor is produced by a usually small but dangerous B-cell clone. Areas covered: This review examines the diagnostic workup of this disease and current knowledge of biomarker-based staging systems. In addition, a risk-adapted treatment approach is presented, as well as an overview of the new treatment strategies. Expert Commentary: The cornerstone of treatment is rapid and effective chemotherapy targeting the underlying plasma cell clone...
January 8, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29305971/more-than-meets-the-eye-time-for-a-new-imaging-paradigm-to-test-for-cardiac-amyloidosis
#14
EDITORIAL
Mathew S Maurer, Frederick L Ruberg, Jonathan W Weinsaft
No abstract text is available yet for this article.
January 3, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29305414/rapid-hematological-responses-improve-outcomes-in-patients-with-very-advanced-stage-iiib-cardiac-immunoglobulin-light-chain-amyloidosis
#15
Richa Manwani, Darren Foard, Shameem Mahmood, Sajitha Sachchithanantham, Thirusha Lane, Cristina Quarta, Taryn Youngstein, Tamer Rezk, Helen J Lachmann, Julian D Gillmore, Marianna Fontana, Carol Whelan, Philip N Hawkins, Ashutosh D Wechalekar
No abstract text is available yet for this article.
January 5, 2018: Haematologica
https://www.readbyqxmd.com/read/29303358/treatment-patterns-and-health-care-resource-utilization-among-patients-with-relapsed-refractory-systemic-light-chain-amyloidosis
#16
Parameswaran Hari, Huamao Mark Lin, Carl V Asche, Jinma Ren, Candice Yong, Katarina Luptakova, Douglas V Faller, Vaishali Sanchorawala
BACKGROUND: Treatment for patients with systemic light chain (AL) amyloidosis remains challenging. Our study aims to describe treatment patterns for both newly diagnosed and relapsed/refractory AL (RRAL) amyloidosis, and to assess clinical outcomes, healthcare costs, and resource utilization during the first year following a diagnosis of RRAL amyloidsis. METHODS: This was a retrospective observational study of adult patients with AL amyloidosis using the US Optum administrative claims data during 1/1/2008 to 6/30/2015...
January 5, 2018: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/29303069/unfolding-cardiac-amyloidosis-from-pathophysiology-to-cure
#17
Klemens Ablasser, Nicolas Verheyen, Theresa Glantschnig, Giulio Agnetti, Peter P Rainer
Deposition of amyloidogenic proteins leading to the formation of amyloid fibrils in the myocardium cause cardiac amyloidosis. Although any form of systemic amyloidosis can affect the heart, light-chain (AL) or transthyretin amyloidosis (ATTR) account for the majority of diagnosed cardiac amyloid deposition. The extent of cardiac disease independently predicts mortality. The reversal or arrest of adverse cardiac remodeling is the target of current therapies, as cardiac-related mortality worsens prognosis in patients where the underlying systemic amyloidosis was successfully treated...
January 4, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29298867/repeat-doses-of-antibody-to-serum-amyloid-p-component-clear-amyloid-deposits-in-patients-with-systemic-amyloidosis
#18
Duncan B Richards, Louise M Cookson, Sharon V Barton, Lia Liefaard, Thirusha Lane, David F Hutt, James M Ritter, Marianna Fontana, James C Moon, Julian D Gillmore, Ashutosh Wechalekar, Philip N Hawkins, Mark B Pepys
Systemic amyloidosis is a fatal disorder caused by pathological extracellular deposits of amyloid fibrils that are always coated with the normal plasma protein, serum amyloid P component (SAP). The small-molecule drug, miridesap, [(R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC)] depletes circulating SAP but leaves some SAP in amyloid deposits. This residual SAP is a specific target for dezamizumab, a fully humanized monoclonal IgG1 anti-SAP antibody that triggers immunotherapeutic clearance of amyloid...
January 3, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29298704/the-prognostic-value-of-t1-mapping-and-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-imaging-in-patients-with-light-chain-amyloidosis
#19
Lu Lin, Xiao Li, Jun Feng, Kai-Ni Shen, Zhuang Tian, Jian Sun, Yue-Ying Mao, Jian Cao, Zheng-Yu Jin, Jian Li, Joseph B Selvanayagam, Yi-Ning Wang
BACKGROUND: Cardiac impairment is associated with high morbidity and mortality in immunoglobulin light chain (AL) type amyloidosis, for which early identification and risk stratification is vital. For myocardial tissue characterization, late gadolinium enhancement (LGE) is a classic and most commonly performed cardiovascular magnetic resonance (CMR) parameter. T1 mapping with native T1 and extracellular volume (ECV) are recently developed quantitative parameters. We aimed to investigate the prognostic value of native T1, ECV and LGE in patients with AL amyloidosis...
January 3, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29288196/hydroxychloroquine-mediated-cardiotoxicity-with-a-false-positive-99mtechnetium-labeled-pyrophosphate-scan-for-transthyretin-related-cardiac-amyloidosis
#20
Ian C Y Chang, John P Bois, Melanie C Bois, Joseph J Maleszewski, Geoffrey B Johnson, Martha Grogan
No abstract text is available yet for this article.
January 2018: Circulation. Cardiovascular Imaging
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