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Amyloidosis

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https://www.readbyqxmd.com/read/28440221/nptx2-and-cognitive-dysfunction-in-alzheimer-s-disease
#1
Mei-Fang Xiao, Desheng Xu, Michael T Craig, Kenneth A Pelkey, Chun-Che Chien, Yang Shi, Juhong Zhang, Susan Resnick, Olga Pletnikova, David Salmon, James Brewer, Steven Edland, Jerzy Wegiel, Benjamin Tycko, Alena Savonenko, Roger H Reeves, Juan C Troncoso, Chris J McBain, Douglas Galasko, Paul F Worley
Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spiking parvalbumin (PV) interneurons that control network excitability and rhythmicity. Excitatory synapses on PV interneurons are dependent on the AMPA receptor subunit GluA4, which is regulated by presynaptic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons...
March 23, 2017: ELife
https://www.readbyqxmd.com/read/28439985/the-utility-of-mass-fix-to-detect-and-monitor-monoclonal-proteins-in-the-clinic
#2
Paolo Milani, David L Murray, David R Barnidge, Mindy C Kohlhagen, John R Mills, Giampaolo Merlini, Surendra Dasari, Angela Dispenzieri
The detection and quantification of monoclonal-proteins (M-proteins) are necessary for the diagnosis and evaluation of response in plasma cell dyscrasias. Immunoglobulin enrichment-coupled with matrix-assisted laser desorption ionization time-of-flight mass-spectrometry (MASS-FIX) is a simple and inexpensive method to identify M-proteins, but its clinical generalizability has not yet been elucidated. We compared MASS-FIX to protein electrophoresis (PEL), serum/urine immunofixation-electrophoresis (IFE) and quantitative serum free-light chain (FLC) for the identification of M-proteins in different clinical diagnoses...
April 25, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28439924/prevalence-and-predictors-of-thyroid-functional-abnormalities-in-newly-diagnosed-al-amyloidosis
#3
E Muchtar, D S Dean, A Dispenzieri, D Dingli, F K Buadi, M Q Lacy, S R Hayman, P Kapoor, N Leung, S Russell, J A Lust, Yi Lin, R Warsame, W Gonsalves, T V Kourelis, R S Go, R Chakraborty, S Zeldenrust, R A Kyle, S Vincent Rajkumar, S K Kumar, M A Gertz
BACKGROUND: Data on the effect of systemic immunoglobulin light chain amyloidosis (AL amyloidosis) on thyroid function are limited. OBJECTIVE: To assess the prevalence of hypothyroidism in AL amyloidosis patients and determine its predictors. METHODS: 1142 newly diagnosed AL amyloidosis patients were grouped based on the thyroid-stimulating hormone (TSH) measurement at diagnosis: hypothyroid group (TSH above upper normal reference; >5 mIU L(-1) ; n = 217, 19% of study participants) and euthyroid group (n = 925, 81%)...
April 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28438056/mass-spectrometry-analysis-for-amyloidosis-typing-is-the-future-bright-for-its-clinical-implementation
#4
Michelle M Hill, Peter N Mollee
No abstract text is available yet for this article.
April 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28437006/prognosis-and-risk-assessment-in-al-amyloidosis-there-and-back-again
#5
EDITORIAL
Efstathios Kastritis, Meletios A Dimopoulos
No abstract text is available yet for this article.
May 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28436370/clinical-neuropathology-image-3-2017-cns-involvement-in-systemic-amyloidosis-restricted-to-the-choroid-plexus
#6
Ellen Gelpi, Martin Susani, Robert Wiebringhaus, Andreas Aschauer, Andreas Kammerlander, Mirjam I Lutz, Johannes A Hainfellner
No abstract text is available yet for this article.
April 24, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28435766/a-heart-too-stiff-to-beat-a-case-of-familial-transthyretin-amyloidosis-cardiomyopathy
#7
Yan Zhou, Sameen Khalid, Aamer Abbass, Laura Hughes, Marcos Hazday
Heart failure is a common clinical syndrome caused by a variety of cardiac diseases. We report a rare case of familial transthyretin amyloidosis cardiomyopathy to heighten the awareness of this rare but lethal cause of heart failure, as therapeutic interventions such as liver or heart transplant could be curative in selected patients.
March 20, 2017: Curēus
https://www.readbyqxmd.com/read/28434927/impact-of-autologous-stem-cell-transplantation-on-the-incidence-and-outcome-of-oligoclonal-bands-in-patients-with-light-chain-amyloidosis
#8
Luis Gerardo Rodríguez-Lobato, Carlos Fernández de Larrea, M Teresa Cibeira, Natalia Tovar, Juan I Aróstegui, Laura Rosiñol, Tania Díaz, Ester Lozano, Montserrat Elena, Jordi Yagüe, Joan Bladé
The emergence of oligoclonal bands (OB) in patients with multiple myeloma achieving a complete remission (CR) after autologous stem cell transplantation (ASCT) and the use of novel agents is a well-recognized event. The presence of OB is associated with favorable outcome. However, the emergence of OB in light-chain (AL) amyloidosis has never been investigated. The aim of the study was to determine the incidence, natural history and prognostic impact of OB in 50 patients with AL amyloidosis who achieved at least a partial response (PR) either after up-front ASCT (20 patients [40%]) or after conventional treatment in patients ineligible for transplant (30 patients [60%])...
April 18, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28434371/immunoparesis-in-newly-diagnosed-al-amyloidosis-is-a-marker-for-response-and-survival
#9
Eli Muchtar, Angela Dispenzieri, Shaji K Kumar, Francis K Buadi, Martha Q Lacy, Steven Zeldenrust, Suzanne R Hayman, Nelson Leung, Taxiarchis V Kourelis, Wilson Gonsalves, Rajshekhar Chakraborty, Steven Russell, David Dingli, John A Lust, Yi Lin, Prashant Kapoor, Ronald Go, Robert A Kyle, S Vincent Rajkumar, Morie A Gertz
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434370/transthyretin-attr-amyloidosis-nephropathy-lessons-from-a-ttr-stabilizer-molecule
#10
Ana Rocha, Ana Silva, Márcio Cardoso, Idalina Beirão, Cristina Alves, Paulo Teles, Teresa Coelho, Luísa Lobato
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434369/seed-dependent-templating-of-murine-aa-amyloidosis
#11
Sofie Nyström, Aida Vahdat Shariat Panahi, K Peter R Nilsson, Per Westermark, Gunilla T Westermark, Per Hammarström, Katarzyna Lundmark
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434368/outcome-of-very-young-%C3%A2-40-years-patients-with-immunoglobulin-light-chain-al-amyloidosis
#12
Jithma P Abeykoon, Jonas Paludo, Angela Dispenzieri, Morie A Gertz, David Dingli, Francis K Baudi, Wilson I Gonsalves, Robert A Kyle, Martha Q Lacy, Suzanne R Hayman, Nelson Leung, Taxiarchis Kourelis, S Vincent Rajkumar, Shaji Kumar, Prashant Kapoor
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434367/a-late-onset-case-of-hereditary-transthyretin-amyloidosis-with-a-novel-compound-heterozygous-mutation
#13
Sayaka Matsumoto, Mitsuharu Ueda, Taro Yamashita, Tomoko Amano, Yohei Misumi, Masayoshi Tasaki, Teruaki Masuda, Mayumi Mizukami, Hirokazu Furuya, Yukio Ando
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434366/recommendations-from-the-amyloidosis-research-consortium-educational-roundtable-at-the-american-college-of-cardiology-annual-meeting-1-april-2016
#14
Mathew Maurer, Isabelle Lousada, Mazen Hanna, Frederick Ruberg, Dania Mohty, Angela Dispenzieri, Michaela Liedtke, Ingrid Paulson, John Vest, Martha Grogan
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434364/the-swedish-landscape-of-hereditary-attr-amyloidosis
#15
Ole B Suhr, Jonas Wixner, Björn Pilebro, Hans-Erik Lundgren, Intissar Anan
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434363/infrared-spectroscopic-imaging-a-label-free-approach-for-the-detection-of-amyloidosis-in-human-tissue-biopsies
#16
David Martinez-Marin, Hari Sreedhar, Michael J Walsh, Maria M Picken
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434361/feasibility-study-of-cardiac-magnetic-resonance-elastography-in-cardiac-amyloidosis
#17
Ian C Y Chang, Arvin Arani, Shivaram Poigai Arunachalam, Martha Grogan, Angela Dispenzieri, Philip A Araoz
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434357/retinol-binding-protein-4-rbp4-concentration-identifies-v122i-transthyretin-cardiac-amyloidosis
#18
Marios Arvanitis, Steven Simon, Gloria Chan, Denise Fine, Paula Beardsley, Michael LaValley, Daniel Jacobson, Clarissa Koch, John L Berk, Lawreen H Connors, Frederick L Ruberg
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434352/the-challenging-histological-diagnosis-of-transthyretin-attr-amyloidosis
#19
Ellahe Charkhkar, Per Westermark
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28434351/end-stage-renal-failure-due-to-transthyretin-amyloidosis-after-liver-transplantation-outcomes-in-19-registry-cases
#20
Ana Rocha, Idalina Beirão, Helena Pessegueiro, Rui Almeida, Luísa Lobato
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
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