keyword
https://read.qxmd.com/read/38155860/sputum-microbiota-and-inflammatory-subtypes-in-asthma-copd-and-its-overlap
#21
JOURNAL ARTICLE
Chie Morimoto, Hisako Matsumoto, Natsuko Nomura, Hironobu Sunadome, Tadao Nagasaki, Susumu Sato, Atsuyasu Sato, Tsuyoshi Oguma, Isao Ito, Mariko Kogo, Keisuke Tomii, Tomoko Tajiri, Kai Ohashi, Takamitsu Tsukahara, Toyohiro Hirai
BACKGROUND: Airway microbiota in asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) remains unknown. OBJECTIVE: This study with ACO-enriched population aimed to clarify airway microbiota in ACO and in mixed granulocytic inflammation, often detected in ACO and chronic airway diseases. METHODS: This is an observational cross-sectional study. Patients with asthma with airflow limitation, ACO, and COPD were enrolled. Blood tests, pulmonary function, exhaled nitric oxide, and sputum tests were conducted...
February 2024: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/38123012/multiomics-was-used-to-clarify-the-mechanism-by-which-air-pollutants-affect-chronic-obstructive-pulmonary-disease-a-human-cohort-study
#22
JOURNAL ARTICLE
Huijun Li, Yanting Yang, Yanpeiyue Yang, Chengkai Zhai, Juan Yao, Wei Liao, Yongbin Wang, Jing Wang, Chenlong Cao, Hany W Darwish, Wei Wu, Wenlong Li, Beilei Ge, You Ma, Hui Wu, Weidong Wu, Fei Zhai
Exposure to air pollutants has been associated with various adverse health outcomes, including chronic obstructive pulmonary disease (COPD). However, the precise underlying mechanism by which air pollution impacts COPD through remains insufficiently understood. To elucidated the molecular mechanism by which air pollutant exposure contributes to alterations in the gut microbiome and metabolism in AECOPD patients, we employed metagenomics and untargeted metabolomics to analyse the gut microbial, faecal, and serum metabolites...
December 18, 2023: Toxicology
https://read.qxmd.com/read/38113524/respiratory-microbiome-profiles-associated-with-distinct-inflammatory-phenotype-and-clinical-indexes-in-chronic-obstructive-pulmonary-disease
#23
JOURNAL ARTICLE
Tao Yu, Yunru Chen, Xiaoxia Ren, Ting Yang
Respiratory microbiome studies have fostered our understanding of the various phenotypes and endotypes of heterogeneous chronic obstructive pulmonary disease (COPD). This study aimed to identify microbiome-driven clusters that reflect the clinical features and dominant microbiota of COPD. This cross-sectional study included 32 patients with stable COPD between December 2019 and December 2020 from the outpatient clinic of China-Japan Friendship Hospital. Sputum samples were tested for 16S rRNA. Patients were classified according to the species level using an unsupervised clustering method to compare the inflammatory phenotypes of two clusters and analyze the correlation between the main bacteria and clinical indicators in each cluster...
December 19, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38050482/copd-in-people-with-hiv-epidemiology-pathogenesis-management-and-prevention-strategies
#24
REVIEW
Katerina L Byanova, Rebecca Abelman, Crystal M North, Stephanie A Christenson, Laurence Huang
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent respiratory symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have demonstrated both higher rates of COPD and an earlier and more rapid decline in lung function than their seronegative counterparts, even after accounting for differences in cigarette smoking. Factors contributing to this HIV-associated difference include chronic immune activation and inflammation, accelerated aging, a predilection for pulmonary infections, alterations in the lung microbiome, and the interplay between HIV and inhalational toxins...
2023: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38048888/mucoactive-drugs-and-multiple-applications-in-pulmonary-disease-therapy
#25
REVIEW
Alexis Hocquigny, Hélène Hugerot, Rosy Ghanem, Tanguy Haute, Véronique Laurent, Virginie Cogulet, Tristan Montier
Mucus is a complex polymeric hydrogel that serves as a critical defense in several organs. In the lungs, it provides a formidable barrier against inhaled particles such as microorganisms. In addition, mucus is essential for normal lung physiology, as it promotes immune tolerance and facilitates a normal commensal pulmonary microbiome. Hypersecretion of airway mucus is a characteristic of numerous respiratory diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF), and creates pulmonary obstruction, limiting the effectiveness of inhaled therapies...
December 2, 2023: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38022823/profiling-of-microbial-landscape-in-lung-of-chronic-obstructive-pulmonary-disease-patients-using-rna-sequencing
#26
JOURNAL ARTICLE
Dongjin Shin, Juhyun Kim, Jang Ho Lee, Jong-Il Kim, Yeon-Mok Oh
PURPOSE: The aim of the study was to use RNA sequencing (RNA-seq) data of lung from chronic obstructive pulmonary disease (COPD) patients to identify the bacteria that are most commonly detected. Additionally, the study sought to investigate the differences in these infections between normal lung tissues and those affected by COPD. PATIENTS AND METHODS: We re-analyzed RNA-seq data of lung from 99 COPD patients and 93 non-COPD smokers to determine the extent to which the metagenomes differed between the two groups and to assess the reliability of the metagenomes...
2023: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/37928173/the-altered-sputum-microbiome-profile-in-patients-with-moderate-and-severe-copd-compared-to-the-healthy-group-in-the-indian-population
#27
JOURNAL ARTICLE
Druti Hazra, Fayaz Sm, Kiran Chawla, Vitali Sintchenko, Elena Martinez, Rahul Magazine, Nayana Siddalingaiah
Background: Microbial culture-independent sequencing techniques have advanced our understanding of host-microbiome interactions in health and disease. The purpose of this study was to explore the dysbiosis of airway microbiota in patients with moderate or severe chronic obstructive pulmonary disease (COPD) and compare them with healthy controls. Methods: The COPD patients were investigated for disease severity based on airflow limitations and divided into moderate (50%≤FEV1<80% predicted) and severe groups (FEV1<50% predicted)...
2023: F1000Research
https://read.qxmd.com/read/37852657/how-inhaled-corticosteroids-target-inflammation-in-copd
#28
REVIEW
Simon Lea, Andrew Higham, Augusta Beech, Dave Singh
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the treatment of COPD. COPD has been previously described as a "corticosteroid-resistant" condition, but current clinical trial evidence shows that selected COPD patients, namely those with increased exacerbation risk plus higher blood eosinophil count (BEC), can benefit from ICS treatment. This review describes the components of inflammation modulated by ICS in COPD and the reasons for the variation in response to ICS between individuals...
December 31, 2023: European Respiratory Review: An Official Journal of the European Respiratory Society
https://read.qxmd.com/read/37703423/investigating-a-causal-role-for-lung-microbiome-dysbiosis-in-early-copd-pathogenesis
#29
JOURNAL ARTICLE
Alexa A Pragman
No abstract text is available yet for this article.
September 13, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/37677136/lower-airway-dysbiosis-augments-lung-inflammatory-injury-in-mild-to-moderate-chronic-obstructive-pulmonary-disease
#30
JOURNAL ARTICLE
Imran Sulaiman, Benjamin G Wu, Matthew Chung, Bradley Isaacs, Jun-Chieh J Tsay, Meredith Holub, Clea R Barnett, Benjamin Kwok, Matthias C Kugler, Jake G Natalini, Shivani Singh, Yonghua Li, Rosemary Schluger, Joseph Carpenito, Destiny Collazo, Luisanny Perez, Yaa Kyeremateng, Miao Chang, Christina D Campbell, Philip M Hansbro, Beno W Oppenheimer, Kenneth I Berger, Roberta M Goldring, Sergei B Koralov, Michael D Weiden, Rui Xiao, Jeanine D'Armiento, Jose C Clemente, Elodie Ghedin, Leopoldo N Segal
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and healthcare costs. Cigarette smoke is a causative factor; however, not all heavy smokers develop COPD. Microbial colonization and infections are contributing factors to disease progression in advanced stages. Objectives: We investigated whether lower airway dysbiosis occurs in mild-to-moderate COPD and analyzed possible mechanistic contributions to COPD pathogenesis. Methods: We recruited 57 patients with a >10 pack-year smoking history: 26 had physiological evidence of COPD, and 31 had normal lung function (smoker control subjects)...
November 15, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/37569672/the-lung-microbiome-in-copd-and-lung-cancer-exploring-the-potential-of-metal-based-drugs
#31
REVIEW
Megan O'Shaughnessy, Orla Sheils, Anne-Marie Baird
Chronic obstructive pulmonary disease (COPD) and lung cancer 17 are two of the most prevalent and debilitating respiratory diseases worldwide, both associated with high morbidity and mortality rates. As major global health concerns, they impose a substantial burden on patients, healthcare systems, and society at large. Despite their distinct aetiologies, lung cancer and COPD share common risk factors, clinical features, and pathological pathways, which have spurred increasing research interest in their co-occurrence...
August 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37555072/the-gut-microbiome-as-a-potential-source-of-non-invasive-biomarkers-of-chronic-obstructive-pulmonary-disease
#32
JOURNAL ARTICLE
Naijian Li, Xinzhu Yi, Chiyong Chen, Zhouli Dai, Zhishan Deng, Jinding Pu, Yumin Zhou, Bing Li, Zhang Wang, Pixin Ran
BACKGROUND: The link between gut microbial dysbiosis and the development of chronic obstructive pulmonary disease (COPD) is of considerable interest. However, little is known regarding the potential for the use of the fecal metagenome for the diagnosis of COPD. METHODS: A total of 80 healthy controls, 31 patients with COPD severity stages I or II, and 49 patients with COPD severity stages III or IV fecal samples were subjected to metagenomic analysis. We characterized the gut microbiome, identified microbial taxonomic and functional markers, and constructed a COPD disease classifier using samples...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37546739/microbial-community-organization-designates-distinct-pulmonary-exacerbation-types-and-predicts-treatment-outcome-in-cystic-fibrosis
#33
Stefanie Widder, Kristopher Opron, Lisa A Carmody, Linda M Kalikin, Lindsay J Caverly, John J LiPuma
Polymicrobial infection of the airways is a hallmark of obstructive lung diseases such as cystic fibrosis (CF), non-CF bronchiectasis, and chronic obstructive pulmonary disease (COPD). Intermittent pulmonary exacerbations (PEx) in these conditions are associated with lung function decline and higher mortality rates. An understanding of the microbial underpinnings of PEx is challenged by high inter-patient variability in airway microbial community profiles. We analyzed 880 near-daily CF sputum samples and developed non-standard microbiome descriptors to model community reorganization prior and during 18 PEx...
July 25, 2023: bioRxiv
https://read.qxmd.com/read/37497248/-chronic-bronchial-infection-in-stable-copd
#34
REVIEW
Juan José Soler-Cataluña, Miguel Angel Martinez-Garcia
Classically, the role of pulmonary infection in patients with chronic obstructive pulmonary disease (COPD) has focused on periods of exacerbation. However, in a clinically stable situation, little attention has been paid to the role play by the presence of potentially pathogenic micro-organisms (especially when they are repeatedly isolated, which is known as chronic bronchial infection [CBI]) in the pathogenesis, prognosis and disease treatment. In recent years, however, some evidence has been published on the deleterious effect of CBI in COPD since it has been associated to greater local inflammation, greater disease severity, poorer health-related quality of life, greater number and severity of exacerbations and cardiovascular events, presence of bronchiectasis, rapid decline of lung function, and even higher mortality (especially related to Pseudomonas aeruginosa infection)...
2023: Open Respir Arch
https://read.qxmd.com/read/37495367/gut-microbiota-composition-and-metabolite-profiling-in-smokers-a-comparative-study-between-emphysema-and-asymptomatic-individuals-with-therapeutic-implications
#35
JOURNAL ARTICLE
Se Hee Lee, Jiseon Kim, Na Hyun Kim, Ock-Hwa Kim, Chang-Ho Shon, Su Jung Kim, Youngwon Jang, Sunmi Yun, Se Eun Lim, So Yi Jung, Hyun Ju Yoo, Sun-Hee Heo, Sei Won Lee
BACKGROUND: Diet has a crucial role in the gut microbiota, and dysbiosis in the gut and lungs has been suggested to be associated with chronic obstructive pulmonary disease. We compared the diet, microbiome and metabolome between asymptomatic smokers and those with emphysema. METHODS: We enrolled 10 asymptomatic smokers with preserved lung function and 16 smokers with emphysema with severe airflow limitation. Dietary intake information was gathered by a self-reported questionnaire...
July 26, 2023: Thorax
https://read.qxmd.com/read/37456520/lung-microbiome-and-origins-of-the-respiratory-diseases
#36
REVIEW
José Belizário, Miguel Garay-Malpartida, Joel Faintuch
The studies on the composition of the human microbiomes in healthy individuals, its variability in the course of inflammation, infection, antibiotic therapy, diets and different pathological conditions have revealed their intra and inter-kingdom relationships. The lung microbiome comprises of major species members of the phylum Bacteroidetes, Firmicutes, Actinobacteria, Fusobacteria and Proteobacteria, which are distributed in ecological niches along nasal cavity, nasopharynx, oropharynx, trachea and in the lungs...
2023: Current research in immunology
https://read.qxmd.com/read/37362620/seasonal-dynamics-of-the-upper-respiratory-tract-microbiome-in-chronic-obstructive-pulmonary-disease
#37
JOURNAL ARTICLE
Shuping Cai, Jingyuan Gao, Xiaomin Liu, Junhao Yang, Dingyun Feng, Guijun Li, Sijia Li, Hailing Yang, Zhang Wang, Xinzhu Yi, Yuqi Zhou
INTRODUCTION: Increasing evidence suggests that seasonal changes can trigger the alternation of airway microbiome. However, the dynamics of the upper airway bacterial ecology of chronic obstructive pulmonary disease (COPD) patients across different seasons remains unclear. METHODS: In this study, we present a 16S ribosomal RNA survey of the airway microbiome on 72 swab samples collected in different months (March, May, July, September, and November) in 2019 from 18 COPD patients and from six resampled patients in November in 2020...
2023: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/37324142/editorial-chronic-airway-diseases-lung-cancer-and-their-interaction
#38
EDITORIAL
Yi Liu, Youming Zhang
No abstract text is available yet for this article.
2023: Frontiers in Medicine
https://read.qxmd.com/read/37321423/lung-microbiota-and-potential-treatment-of-respiratory-diseases
#39
REVIEW
Yaxuan Zhou, Mengjun Liu, Kaixuan Liu, Guojun Wu, Yurong Tan
The unique microbiome found in the lungs has been studied and shown to be associated with both pulmonary homeostasis and lung diseases. The lung microbiome has the potential to produce metabolites that modulate host-microbe interactions. Specifically, short-chain fatty acids (SCFAs) produced by certain strains of the lung microbiota have been shown to regulate immune function and maintain gut mucosal health. In response, this review described the distribution and composition of the microbiota in lung diseases and discussed the impact of the lung microbiota on health and lung disease...
June 13, 2023: Microbial Pathogenesis
https://read.qxmd.com/read/37321178/correcting-dysbiosis-in-the-lungs-of-copd-one-pathogen-at-a-time
#40
JOURNAL ARTICLE
Kendrew K Wong, Leopoldo N Segal
In this issue of Cell Host & Microbe, Liang et al. demonstrate through genomic analysis of the sputum microbiome from COPD patients and preclinical models that Staphylococcus aureus promotes lung function decline via regulation of homocysteine levels. Homocysteine can promote lung injury by promoting neutrophil apoptosis-to-NETosis shift via AKT1-S100A8/A9 axis.
June 14, 2023: Cell Host & Microbe
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