Iakovos Saridakis, Margaux Riomet, Oliver J V Belleza, Guilhem Coussanes, Nadja K Singer, Nina Kastner, Yi Xiao, Elliot Smith, Veronica Tona, Aurélien de la Torre, Eric F Lopes, Pedro A Sánchez-Murcia, Leticia González, Harald H Sitte, Nuno Maulide
The deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60 examples) and display Stokes shifts as large as 240 nm, while also reaching NIR-I emissions at λmax as long as 720 nm...
April 3, 2024: Angewandte Chemie