Xinyuan Wang, Xueqin Yang, Guanyu Jiang, Zhubin Hu, Tao Liao, Guoxin Wang, Xun Zhang, Xinyuan He, Jianyu Zhang, Jianquan Zhang, Wuke Cao, Kaizhen Zhang, Jacky W Y Lam, Jianwei Sun, Haitao Sun, Yongye Liang, Ben Zhong Tang
Fluorescent imaging and biosensing in the near-infrared-II (NIR-II) window holds great promise for non-invasive, radiation-free, and rapid-response clinical diagnosis. However, it's still challenging to develop bright NIR-II fluorophores. In this study, we report a new strategy to enhance the brightness of NIR-II aggregation-induced emission (AIE) fluorophores through intramolecular electrostatic locking. By introducing sulfur atoms into the side chains of the thiophene bridge in TSEH molecule, the molecular motion of the conjugated backbone can be locked through intramolecular interactions between the sulfur and nitrogen atoms...
May 7, 2024: Angewandte Chemie