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https://www.readbyqxmd.com/read/29053910/a-simplified-protocol-using-rituximab-and-immunoglobulin-for-abo-incompatible-low-titer-living-donor-liver-transplantation
#1
Seong Hoon Kim, Eung Chang Lee, Jae Ryong Shim, Sang Jae Park
BACKGROUND & AIMS: No consensus has been reached regarding optimal treatment strategies for ABO-incompatible (ABO-I) living donor liver transplantation (LDLT). We introduce a simplified protocol using rituximab and intravenous immunoglobulin (IVIG). METHODS: Data were analyzed on adult patients who underwent ABO-I LDLT of which protocol added rituximab (300 mg/m(2) ) before surgery and IVIG (0.8 g/kg) on postoperative days 1 and 4 to the conventional immunosuppressive regimen used in ABO-compatible (ABO-C) LDLT, without plasmapheresis, splenectomy, or graft local infusion...
October 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29053394/vedroprevir-in-the-management-of-hepatitis-c-virus-infection
#2
Ameer Abutaleb, Shyamasundaran Kottilil
Introduction Hepatitis C Virus (HCV) is a chronic infection of the liver and the leading cause of liver failure and liver transplantation worldwide. While prior HCV therapies were prolonged and had variable success rates, the advent of direct-acting antivirals (DAAs) has dramatically improved HCV therapy with minimal side effects, shorter treatment durations, and higher cure rates. Areas covered In this paper, we review the literature discussing the use of Vedroprevir (GS-9451) in treatment of HCV in a variety of patient populations...
October 20, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29052532/stereotactic-body-radiation-therapy-sbrt-for-definitive-treatment-and-as-a-bridge-to-liver-transplantation-in-early-stage-inoperable-hepatocellular-carcinoma
#3
Assaf Moore, Michal Cohen-Naftaly, Anna Tobar, Yulia Kundel, Ofer Benjaminov, Marius Braun, Assaf Issachar, Eytan Mor, Michal Sarfaty, Dimitri Bragilovski, Ran Ben Hur, Noa Gordon, Salomon M Stemmer, Aaron M Allen
BACKGROUND AND PURPOSE: Stereotactic body radiotherapy (SBRT) is an emerging modality for definitive treatment of Hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study included all early stage HCC patients who were not candidates for primary resection and/or local therapy, treated with SBRT between 11/2011 and 1/2016. RESULTS: Twenty-three patients were included. The median age was 62 years; 70% males; 30% females; 70% viral hepatitis carriers; 100% cirrhotic; 13 Child Pugh [CP]-A and 10 [CP]-B...
October 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29052367/decellularized-caprine-liver-extracellular-matrix-as-a-2d-substrate-coating-and-3d-hydrogel-platform-for-vascularized-liver-tissue-engineering
#4
Tarun Agarwal, Rajan Narayan, Somnath Maji, Sudip Kumar Ghosh, Tapas Kumar Maiti
Development of a vascularized liver tissue construct is a need of an hour to circumvent the current demand of liver transplantation in healthcare sector. An appropriate matrix must support liver cell viability, functionality, and development of microvasculature. With this perspective, here, we report the use of decellularized Caprine liver ECM (CLECM) derived hydrogel for tissue engineering applications. First, CLECM was used as a substrate coating material for 2D hepatocyte culture. HepG2 cells cultured on CLECM coated surface showed higher albumin, urea, glycogen and GAGs synthesis in comparison to collagen coated surface (taken as control for the study)...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29051789/novel-strategies-and-therapeutic-options-for-the-management-of-primary-biliary-cholangitis
#5
REVIEW
Amardeep Khanna, David E Jones
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease. It has a varied course of progression ranging from being completely asymptomatic to aggressive disease leading to cirrhosis and resulting in liver transplantation. In addition, symptoms can be debilitating and can have a major impact on quality of life. For decades, there was only one anti-cholestatic agent available to target this disease and that was only effective in around half of patients, with little or no effect on symptoms. With increasing understanding of the pathogenic mechanisms of PBC and potential targets for drug treatment, pharmaceutical companies have shown a greater interest in this rare disease...
October 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29051476/independent-factors-predicting-postoperative-30-day-mortality-in-101-infants-following-liver-transplantation
#6
Chan Woo Cho, Sanghoon Lee, Jong Man Kim, Gyu-Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh, Suk-Koo Lee
BACKGROUND Liver transplantation (LT) in infants is a challenging procedure. This study was designed to identify risk factors of 30-day mortality of infant LT recipients. MATERIAL AND METHODS A total of 101 infants treated between May 1997 and March 2015 were assigned to one of two groups, a deceased infant group (n=9) or a live infant group (n=92), according to their mortality status at 30 days after LT. RESULTS Patient characteristics of height, weight, preoperative total bilirubin, creatinine clearance, primary diagnosis, and graft-to-recipient weight ratio (GRWR) were significantly different between the two groups...
October 20, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29050854/pretransplantation-portal-vein-recanalization-and-transjugular-intrahepatic-portosystemic-shunt-creation-for-chronic-portal-vein-thrombosis-final-analysis-of-a-61-patient-cohort
#7
Bartley Thornburg, Kush Desai, Ryan Hickey, Elias Hohlastos, Laura Kulik, Daniel Ganger, Talia Baker, Michael Abecassis, Juan C Caicedo, Daniela Ladner, Jonathan Fryer, Ahsun Riaz, Robert J Lewandowski, Riad Salem
PURPOSE: To report the final analysis of the safety and efficacy of portal vein (PV) recanalization (PVR) and transjugular intrahepatic portosystemic shunt (TIPS) creation (PVR-TIPS) in patients with PV thrombosis (PVT) in need of liver transplantation. MATERIALS AND METHODS: Sixty-one patients with cirrhosis and PVT underwent PVR-TIPS to improve transplantation candidacy. Median patient age was 58 years (range, 22-75 y), and median pre-TIPS Model for End-Stage Liver Disease score was 14 (range, 7-42)...
October 17, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29050276/a-new-donors-cyp3a5-and-recipients-cyp3a4-cluster-predicting-tacrolimus-disposition-and-new-onset-hypertension-in-chinese-liver-transplant-patients
#8
Yuan Liu, Tao Zhang, Xiaoqing Zhang, Ling Ye, Haitao Gu, Lin Zhong, Hongcheng Sun, Chenlong Song, Zhihai Peng, Junwei Fan
AIM: The purpose of the current study was to investigate individualized therapy of tacrolimus (Tac), as well as complications after liver transplantation (LT) with the known genetic determinants and clinical factors. METHODS: In this retrospective study, two cohorts (n=170) from the China Liver Transplant Registry (CLTR) database from July 2007 to March 2015 were included. RESULTS: Both donors' CYP3A5*3 and recipients' CYP3A4*1G had a correlation with Tac pharmacokinetics at four weeks (all P<0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050191/-the-ocular-involvement-in-the-transthyretin-related-familial-amyloid-polyneuropathy
#9
H Y Lin, R P Dai
Transthyretin (TTR)-related familial amyloid polyneuropathy (FAP), which is caused by mutant TTR, is a rare but fatal autosomal dominant disease. TTR is synthesized by the liver (95%) , the choroid plexus of the brain and the retinal pigment epithelium. FAP leads to peripheral neuropathy, and the main ocular manifestations are vitreous opacity (yellowish cotton-like), secondary glaucoma and keratoconjunctivitis sicca. Liver transplantation has proven to be the most effective treatment for TTR-FAP. Nowadays, tafamidis is the only drug approved for TTR-FAP (early stage)...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050033/expert-panel-statement-on-laparoscopic-living-donor-hepatectomy
#10
Ho-Seong Han, Jai Young Cho, Hironori Kaneko, Go Wakabayashi, Hideaki Okajima, Shinji Uemoto, Olivier Soubrane, Chee-Chien Yong, Chao-Long Chen, Tan To Cheung, Giulio Belli, Shoji Kubo, Yao-Ming Wu, Kuo-Hsin Chen, Roberto I Troisi, Choon Hyuck David Kwon, Kyung-Suk Suh, Arvinder S Soin, Ki-Hun Kim, Daniel Cherqui
BACKGROUND: With improvements in living donor liver transplantation (LDLT) techniques and the increased experience of surgeons in laparoscopic major liver resection, laparoscopic donor hepatectomy is performed increasingly. Therefore, expert opinion on this procedure is required. OBJECTIVE: The study aimed to report the current status and summarize the expert opinion on laparoscopic donor hepatectomy. METHODS: An expert consensus meeting was held on September 8, 2016, in Seoul, Korea...
October 20, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29049612/long-term-change-in-the-risk-of-skin-cancer-after-organ-transplantation-a-population-based-nationwide-cohort-study
#11
Syed Mohammad Husain Rizvi, Bjarte Aagnes, Hallvard Holdaas, Einar Gude, Kristin Muri Boberg, Øystein Bjørtuft, Per Helsing, Torbjørn Leivestad, Bjørn Møller, Petter Gjersvik
Importance: The high risk of skin cancer after organ transplantation is a major clinical challenge and well documented, but reports on temporal trends in the risk of posttransplant cutaneous squamous cell carcinoma (SCC) are few and appear contradictory. Objective: To study temporal trends for the risk of skin cancer, particularly SCC, after organ transplantation. Design, Setting, and Participants: Population-based, nationwide, prospective cohort study of 8026 patients receiving a kidney, heart, lung, or liver transplant in Norway from 1968 through 2012 using patient data linked to a national cancer registry...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29049126/shear-wave-elastography-for-the-assessment-of-liver-fibrosis-in-liver-transplant-recipients-treated-for-hepatitis-c-virus-recurrence
#12
David Korda, Zsuzsanna M Lenard, Zsuzsanna Gerlei, Zsuzsanna Jakab, Anita Haboub-Sandil, Laszlo Wagner, Marina Varga, Orsolya Cseprekal, Adrienn Marton, Denes Horvathy, Szabolcs Takacs, Attila Doros, Zoltan Mathe
OBJECTIVES: Direct-acting antiviral agents have revolutionized hepatitis C therapy, and are also found to be effective in the liver transplant setting. The extent of liver fibrosis influences patient management and is used to monitor therapeutic effects. Shear-wave elastography (SWE) is a relatively new imaging-based method that has not yet been studied extensively in liver transplant patients. Our aim was to study the effect of direct-acting antivirals in heaptitis C recurrence on liver stiffness determined by SWE...
October 18, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29049107/venovenous-bypass-associated-with-acute-kidney-injury-prevention-in-liver-transplantation-an-ode-to-the-retrospective-data-researcher
#13
Teus H Kappen, Stuart A McCluskey
No abstract text is available yet for this article.
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29046779/anesthetic-management-during-the-first-combined-heart-liver-transplant-performed-in-korea-a-case-report
#14
Hyejin Park, Jungchan Park, Jonghwan Lee, Gaabsoo Kim
Herein, we describe the anesthetic management during the first combined heart-liver transplant (CHLT) performed in Korea. Though CHLT is a rare procedure, accumulating evidence suggests that it is a feasible option for patients with coexisting heart and liver failure. A 45-year-old female patient presented with severe cardiac dysfunction requiring extracorporeal membrane oxygenation (ECMO) support and secondary congestive hepatopathy. The patient underwent consecutive heart and liver transplantation using extracorporeal circulatory devices-heart transplant with cardiopulmonary bypass, and liver transplant with peripheral ECMO...
October 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29046057/bile-duct-ligature-in-young-rats-a-revisited-animal-model-for-biliary-atresia
#15
Matias Garrido, Camila Escobar, Constanza Zamora, Carolina Rejas, Juan Varas, Mario Párraga, Sebastian San Martin, Sandra Montedónico
Biliary atresia leads to cirrhosis in the vast majority of patients and constitutes the first cause of paediatric liver transplantation. Animal models allow us to understand the molecular basis and natural history of diseases. The aim of this study is to describe a surgically created animal model of biliary atresia with emphasis in long-term liver function. Forty-two 3-week-old Sprague-Dawley rats were randomly divided into two groups: bile duct ligature (BDL) and control. The animals were sacrificed on the 2nd, 4th, and 6th postoperative weeks...
September 13, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29045810/a-novel-next-generation-sequencing-assay-as-an-alternative-to-currently-available-methods-for-hepatitis-c-virus-genotyping
#16
G Dirani, E Paesini, E Mascetra, P Farabegoli, B Dalmo, B Bartolini, A R Garbuglia, M R Capobianchi, V Samri
Chronic HCV infection is one of the leading causes of liver-related death and in many countries it is a primary reason for having a liver transplant. HCV genotype identification has long been used in the clinical practice, since different genotypes have different response rates and required different doses and durations of IFN/RBV treatment; moreover both the frequency and the pattern of resistance to different Direct-Acting Antivirals (DAAs) classes are subtype specific. Hence the necessity to make an accurate HCV subtyping becomes a fundamental tool to optimize current and future clinical management of HCV infected subjects...
October 15, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29045352/impact-of-race-and-ethnicity-on-outcomes-for-children-waitlisted-for-pediatric-liver-transplantation
#17
Douglas B Mogul, Xun Luo, Eric K Chow, Allan B Massie, Tanjala S Purnell, Kathleen B Schwarz, Andrew M Cameron, John F P Bridges, Dorry L Segev
OBJECTIVE: African Americans and other minorities are known to face barriers to health care influencing their access to organ transplantation but it is not known whether these barriers exist among pediatric liver transplant waitlist candidates. We sought to determine whether outcomes on the waitlist (i.e., mortality, deceased donor liver transplantation (DDLT), and living-donor liver transplantation (LDLT)) varied by race/ethnicity. METHODS: National registry data were studied to estimate the race/ethnicity-specific risk of waitlist mortality, DDLT and LDLT in children (<18 years) waitlisted between March, 2002 and March, 2015...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29045240/prediction-of-thromboembolic-complications-after-liver-resection-for-cholangiocarcinoma-is-there-a-place-for-thromboelastometry
#18
Annabel Blasi, Victor Molina, Santiago Sanchez-Cabús, Jaume Balust, J Carlos Garcia-Valdecasas, Pilar Taura
: Postoperative venous thromboembolism has a poor prognosis in patients with cancer. We aimed to investigate the utility of thromboelastometry in detecting the risk of postoperative venous thromboembolism in patients with cholangiocarcinoma. We prospectively included patients submitted to liver resection for cholangiocarcinoma at our hospital between May 2011 and July 2014. Patients undergoing major hepatectomy for adult living donor transplantation in the same time period served as a control group. Thromboelastometry was performed before anesthesia...
October 17, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29044911/split-graft-liver-transplantation-from-an-adult-donor-with-an-unrecognized-ucd-to-a-pediatric-and-adult-recipient
#19
C H Lee, C Ellaway, A Shun, G Thomas, P Nair, J O'Neill, N Shakel, M O Stormon
We report the outcomes of an adult and pediatric split liver transplant from an adult male donor who died due to an unrecognized UCD, OTC deficiency. Recognizing inborn errors of metabolism can be challenging, especially in adult centers where such disorders are rarely encountered. Shortage of donors for liver transplantation has led to procedures to maximize donor utilization, such as split and live donor grafts. The cause of death should be ascertained before accepting a cadaveric donor organ.
October 16, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29044759/liver-transplant-length-of-stay-los-index-a-novel-predictive-score-for-hospital-length-of-stay-following-liver-transplantation
#20
Abbas Rana, Ellen D Witte, Karim J Halazun, Gagan K Sood, Ayse L Mindikoglu, Norman Sussman, John M Vierling, Michael L Kueht, N Thao N Galvan, Ronald T Cotton, Christine A O'Mahony, John A Goss
An index to predict hospital length of stay after liver transplantation could address unmet clinical needs. Length of stay is an important surrogate for hospital costs and efforts to limit stays can preserve our healthcare resources. Here, we devised a scoring system that predicts hospital length of stay following liver transplantation. We used univariate and multivariate analyses on 73,635 adult liver transplant recipient data and identified independent recipient and donor risk factors for prolonged hospital stay (> 30 days)...
October 17, 2017: Clinical Transplantation
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