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https://www.readbyqxmd.com/read/29908364/non-alcoholic-steatohepatitis-is-the-fastest-growing-cause-of-hepatocellular-carcinoma-in-liver-transplant-candidates
#1
Zobair Younossi, Maria Stepanova, Janus P Ong, Ira M Jacobson, Elisabetta Bugianesi, Ajay Duseja, Yuichiro Eguchi, Vincent W Wong, Francesco Negro, Yusuf Yilmaz, Manuel Romero-Gomez, Jacob George, Aijaz Ahmed, Robert Wong, Issah Younossi, Mariam Ziayee, Arian Afendy
BACKGROUND: While hepatitis B and C have been the main drivers of hepatocellular carcinoma (HCC), non-alcoholic steatohepatitis (NASH) has recently become an important cause of HCC. The aim of this study was to assess the causes of HCC among liver transplant (LT) candidates in the U.S. METHODS: The Scientific Registry of Transplant Recipients (2002-2016) was used to estimate the trends in prevalence of HCC in LT candidates with the most common types of chronic liver disease: alcoholic liver disease (ALD), chronic hepatitis B (CHB), chronic hepatitis C, and NASH...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908044/utilization-and-efficacy-of-elbasvir-grazoprevir-for-treating-hepatitis-c-virus-infection-after-liver-transplantation
#2
Satoshi Miuma, Hisamitsu Miyaaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Hidetaka Shibata, Naota Taura, Susumu Eguchi, Kazuhiko Nakao
AIM: Recently, elbasvir/grazoprevir combination therapy (EBR/GZR therapy) has been reported to have excellent antiviral effects for chronic genotype 1 hepatitis C virus (HCV) infection. However, it has not been recommended for patients with post-liver transplant (LT) HCV re-infections because of a lack of evidence for effectiveness and drug-drug interactions. METHODS: We report the usage of EBR/GZR in five post-LT HCV re-infected patients with the kinetics of renal function and tacrolimus (Tac) trough levels during and after therapy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29908011/pretransplant-increases-in-left-ventricular-volume-and-mass-are-associated-with-qt-prolongation-during-pediatric-liver-transplantation
#3
Hyun-Seok Cho, Wook-Jong Kim, Byungdoo Andrew Lee, Junki Cho, Won-Jung Shin, Gyu-Sam Hwang
Structural alterations in the cirrhotic heart may contribute to electromechanical abnormalities, represented by QT prolongation. The aim of this study was to investigate the changes in QTc according to the operative stage during pediatric LT and to identify which baseline echocardiographic parameters were associated with intraoperative QTc prolongation. Data were evaluated from 39 children undergoing LT for chronic liver disease (median age 9 months). In 19 patients (48.7%), baseline QTc was prolonged ≥440 ms (462 ± 19 ms)...
June 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29907993/comparison-of-histidine-tryptophan-ketoglutarate-and-university-of-wisconsin-preservation-solutions-in-pediatric-liver-transplantation
#4
Richard S Mangus, Joel R Schroering, Taylor J Hathaway, Chandrashekhar A Kubal, Jonathan A Fridell
UW and HTK solutions are the two primary organ preservation solutions most used in the United States. This study analyzes use of the two solutions in all pediatric liver transplants performed at a single center between 2001and 2017. Outcome measures included early graft function, as well as graft and patient survival. Bile duct complications were reviewed. Operative technique, immunosuppressive protocols, and donor acceptance criteria remained uniform among participating surgeons throughout the study period...
June 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29907976/outcomes-of-domino-liver-transplantation-compared-to-deceased-donor-liver-transplantation-a-propensity-matching-approach
#5
Emily D Geyer, Candice Burrier, Dmitry Tumin, Don Hayes, Sylvester M Black, W Kenneth Washburn, Joseph D Tobias
INTRODUCTION: Domino liver transplantation (DLT) utilizes the explanted liver of one liver transplant recipient as a donor graft in another patient. While there may be unique risks associated with DLT, it is unclear if DLT has less favorable long term outcomes than deceased donor liver transplantation (DDLT). We used a propensity score matching approach to compare the outcomes of DLT recipients to DDLT recipients in a large national registry. METHODS: The United Network for Organ Sharing registry was queried for patients undergoing DLT or DDLT in 2002-2016...
June 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29907534/significant-infections-in-liver-transplant-recipients-undergoing-endoscopic-retrograde-cholangiography-are-few-and-unaffected-by-prophylactic-antibiotics
#6
Divyanshoo R Kohli, Tilak U Shah, Doumit S BouHaidar, Ravi Vachhani, M Shadab Siddiqui
INTRODUCTION: Current practice guidelines recommend prophylactic antibiotics prior to endoscopic retrograde cholangiopancreatography (ERCP) in liver transplant recipients (LTR). This study evaluated the risk of clinically significant infections after ERCP in LTR who received antibiotic prophylaxis compared to those who did not. METHODS: This retrospective case-cohort study evaluated all LTR who underwent elective, outpatient ERCP from 2008 to 2015. Hospitalized patients, pediatric allograft recipients and patients with cholangitis or incomplete biliary drainage were excluded...
May 28, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29907370/outcome-of-transplantation-performed-outside-the-regular-working-hours-a-systematic-review-and-meta-analysis-of-the-literature
#7
REVIEW
Jore Hendrikx, Dirk Van Raemdonck, Jacques Pirenne, Steffen Fieuws, Steffen Rex
Transplant procedures are frequently performed outside the regular working hours (after hours). In general surgery, several studies observed worse outcomes for operations performed after hours. The predetermined hypothesis was that patients undergoing transplantation during after hours might suffer from an excess in post-operative mortality and morbidity when compared to patients undergoing transplantations during the regular working hours. A systematic review of the PubMed database identified 11,993 records, of which eleven cohort studies including a total of 287,741 patients investigated the association between the starting time of transplant surgery and postoperative mortality (primary outcome) and/or morbidity (secondary outcome)...
May 8, 2018: Transplantation Reviews
https://www.readbyqxmd.com/read/29906299/eluding-liver-transplantation-in-posttext-iii-and-iv-hepatoblastoma
#8
Ahmed El-Gendi, Shady Fadel, Mohamed El-Shafei, Ahmed Shawky
BACKGROUND: Primary liver transplantation is recommended for central POSTTEXT III and POSTTEXT IV hepatoblastoma. Aim is to prospectively assess safety, oncological efficacy of aggressive non-transplant extended hepatic resections in those patients. METHODS: A prospective study included 18 children with central PRETEXT III and IV, 3 had primary liver transplantation whereas 15 underwent hepatic resection after neoadjuvant chemotherapy. RESULTS: Median tumor volume was 317 ml (range 135-546)...
June 15, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29906233/metastasectomy-of-hepatoblastoma-utilizing-a-novel-overlay-fluorescence-imaging-system
#9
Yohei Yamada, Ken Hoshino, Teisaburo Mori, Miho Kawaida, Kiyotomo Abe, Nobuhiro Takahashi, Takumi Fujimura, Kaori Kameyama, Tatsuo Kuroda
BACKGROUND: The curability of hepatoblastoma (HB) largely depends on the achievement of radical surgical resection, even for metastatic tumors. However, the extension of the metastatic tumor when viewed through an endoscope with the conventional white-light mode is often unclear. Advancements in imaging technology utilizing indocyanine green (ICG) have facilitated precise resection of metastatic HBs, owing to the longer retention of ICG in such lesions than in other normal tissues. CASE: We utilized an endoscope loaded with the PINPOINT system (NOVADAQ Technologies, Inc...
June 15, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29904504/use-of-a-mechanical-thrombectomy-device-to-treat-early-hepatic-artery-thrombosis-after-orthotopic-liver-transplant
#10
James C Meek, Jonathan S McDougal, Daniel Borja-Cacho, Mary E Meek
Hepatic artery thrombosis (HAT) is a major cause of morbidity and mortality after orthotopic liver transplantation, occurring in 5% of cases (Piardi et al, 2016). HAT is the second main cause of graft loss after primary nonfunction, the leading cause of graft failure in the immediate postoperative period (<1 month), and is associated with a mortality rate of up to 60% without intervention (Piardi et al, 2016; Pareja et al., 2010; Crossin et al., 2003). Although retransplantation is the preferred therapy, the limited availability of donor organs can necessitate urgent, alternative treatment...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904458/left-main-coronary-artery-diverticulum-case-report-and-review-of-the-literature
#11
Hassan Tahir, Timothy Kennedy, M Umer Awan, Bassam Omar, Christopher Malozzi, G Mustafa Awan
Coronary artery disease is a major cause of morbidity and mortality, and while most commonly is atherosclerotic, it can present with variable manifestations, both congenital and acquired. One such manifestation is coronary aneurysm, which is a localized dilatation of a coronary artery wall segment to greater than 1.5 times the adjacent normal segments. While a dilated outpouching of a coronary artery has been commonly classified as a coronary aneurysm, a non-dilated outpouching is rare and is referred to as a diverticulum, with only one previous case report in the literature...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29904384/mapping-determinants-of-virus-neutralization-and-viral-escape-for-rational-design-of-a-hepatitis-c-virus-vaccine
#12
REVIEW
Mei-Le Keck, Florian Wrensch, Brian G Pierce, Thomas F Baumert, Steven K H Foung
Hepatitis C virus (HCV) continues to spread worldwide with an annual increase of 1.75 million new infections. The number of HCV cases in the U.S. is now greater than the number of HIV cases and is increasing in young adults because of the opioid epidemic sweeping the country. HCV-related liver disease is the leading indication of liver transplantation. An effective vaccine is of paramount importance to control and prevent HCV infection. While this vaccine will need to induce both cellular and humoral immunity, this review is focused on the required antibody responses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29903871/liver-and-colon-specific-dna-methylation-markers-in-plasma-for-investigation-of-colorectal-cancers-with-or-without-liver-metastases
#13
Wanxia Gai, Lu Ji, W K Jacky Lam, Kun Sun, Peiyong Jiang, Anthony W H Chan, John Wong, Paul B S Lai, Simon S M Ng, Brigette B Y Ma, Grace L H Wong, Vincent W S Wong, Henry L Y Chan, Rossa W K Chiu, Y M Dennis Lo, K C Allen Chan
BACKGROUND: Measurement of DNA derived from different tissues in the circulating DNA pool can provide important information regarding the presence of many pathological conditions. However, existing methods involving genome-wide bisulfite sequencing are relatively expensive and may present challenges for large-scale analysis. METHODS: Through identifying differentially methylated regions in the liver and colon compared with other tissues, we identified 2 markers and developed corresponding droplet digital PCR assays...
June 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29902957/is-muscle-meld-a-more-promising-predictor-for-mortality-after-living-donor-liver-transplantation
#14
Amr Badawy, Toshimi Kaido, Yuhei Hamaguchi, Takayuki Anazawa, Shintaro Yagi, Ken Fukumitsu, Naoko Kamo, Hideaki Okajima, Shinji Uemoto
BACKGROUND: To improve the outcome of living donor liver transplantation (LDLT), a scoring system that could predict accurately the patient and graft survival posttransplant is necessary. The aim of this study is to evaluate our previously proposed Muscle-model for end-stage liver disease (M-MELD) score and to compare it with the other available scores to find the best system that correlates with postoperative outcome after liver transplant. METHODS: We retrospectively reviewed the data of 199 patients who underwent LDLT from January 2010 to July 2016 and calculated the preoperative MELD, MELD Na, the product of donor age and MELD (D-MELD), M-MELD, integrated MELD, and the balance of risk (BAR) score in all patients...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29901618/management-of-hepatic-vein-occlusive-disease-after-liver-transplantation-a-case-report-with-literature-review
#15
Yuchen Hou, Nga Lei Tam, Zhicheng Xue, Xuzhi Zhang, Bing Liao, Jie Yang, Shunjun Fu, Yi Ma, Linwei Wu, Xiaoshun He
RATIONALE: Hepatic vein occlusive disease (HVOD) is a rare complication after liver transplantation, which is characterized by nonthrombotic, fibrous obliteration of the small centrilobular hepatic veins by connective tissue and centrilobular necrosis in zone 3 of the acini. HVOD after solid organ transplantation has been reported; recently, most of these reports with limited cases have documented that acute cell rejection and immunosuppressive agents are the major causative factors. HVOD is relatively a rare complication of liver transplantation with the incidence of approximately 2%...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901589/quality-of-life-and-care-burden-in-primary-caregivers-of-liver-transplantation-recipients-in-china
#16
Linbo Wei, Juan Li, Yanpei Cao, Jianming Xu, Wei Qin, Huijuan Lu
So far, liver transplantation (LT) has become the most effective way to treat end-stage liver-related diseases. As we all know, a stable caregiver is crucial to LT recovery. However, compared with LT patients, few studies were focused on LT caregivers.This study aimed to describe the quality of life (QoL), care burden, and their related factors in caregivers of LT patients in Shanghai, China.We collected 225 liver transplanted patients and their corresponding caregivers' social demographic and medical information; meanwhile, we assessed 225 LT recipients' caregivers' life quality; by using Caregiver Quality of Life Index-Liver Transplantation in Chinese version (CQOLC-LT), Zarit caregiver burden inventory in Chinese version (ZBI) was used to access the care burden...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901555/spectrum-of-pediatric-autoimmune-liver-disease-and-validation-of-its-diagnostic-scores-in-indian-children
#17
Vikrant Sood, Bikrant Bihari Lal, Dinesh Rawat, Rajeev Khanna, Archana Rastogi, Chhagan Bihari, Guresh Kumar, Seema Alam
OBJECTIVES: There is limitedliterature on the spectrum of pediatric autoimmune liver disease (AILD, encompassing both autoimmune hepatitis/AIH and autoimmune sclerosing cholangitis/ASC) in Asian populations and its diagnostic scores similarly require further validation. This work thus aimed to study the clinical characteristics, and to validate available diagnostic criteria in the local pediatric AILD cohort. METHODS: A review of all pediatric AILD cases, presenting over a 6 year (2011-2017) period was done, along with comparison of the available diagnostic scores: original (1999), simplified (2008) score and new proposed (2017) score...
June 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29901259/the-role-of-mri-and-ercp-in-the-evaluation-of-disease-activity-and-severity-in-primary-sclerosing-cholangitis
#18
Andrea Tenca, Harri Mustonen, Kati Lind, Eila Lantto, Kaija-Leena Kolho, Sonja Boyd, Johanna Arola, Kalle Jokelainen, Martti Färkkilä
BACKGROUND AND AIMS: Endoscopic retrograde cholangiography (ERCP) has been considered the gold standard for the diagnosis and follow-up of primary sclerosing cholangitis, but it has been replaced by less invasive magnetic resonance imaging and cholangio-pancreatography (MRI-MRCP). However, the role of these two techniques in the evaluation of disease activity and severity needs to be elucidated. METHODS: Patients with primary sclerosing cholangitis (n: 48, male 31, median age: 35...
June 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29900755/exploring-the-role-of-oncolytic-viruses-in-hepatobiliary-cancers
#19
Pavan Tenneti, Mitesh J Board, Hani M Babiker
The standard of care for early hepatobiliary cancers (HBC) includes surgical resection. Liver transplantations or locoregional therapies are beneficial in early hepatocellular carcinoma (HCC) under certain circumstances. Systemic treatments have some benefit in advanced HBC, though long-term prognosis remains poor. We evaluated the role of oncolytic viruses in the treatment of HBCs through a systematic literature review. The recombinant vaccinia virus JX-594 improved median survival in patients with local/metastatic HCC more strongly at high dose than at low dose (14...
June 14, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29900673/dynamics-of-virus-specific-t-cell-immunity-in-pediatric-liver-transplant-recipients
#20
R J Arasaratnam, I Tzannou, T Gray, P I Aguayo-Hiraldo, M Kuvalekar, S Naik, A Gaikwad, H Liu, T Miloh, J F Vera, R W Himes, F M Munoz, A M Leen
Immunosuppression following solid organ transplantation (SOT) has a deleterious effect on cellular immunity leading to frequent and prolonged viral infections. To better understand the relationship between post-transplant immunosuppression and circulating virus-specific T cells, we prospectively monitored the frequency and function of T cells directed to a range of latent (CMV, EBV, HHV6, BK) and lytic (AdV) viruses in 16 children undergoing liver transplantation for up to 1 year post-transplant. Following transplant, there was an immediate decline in circulating virus-specific T cells, which recovered post-transplant, coincident with the introduction and subsequent routine tapering of immunosuppression...
June 13, 2018: American Journal of Transplantation
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