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https://www.readbyqxmd.com/read/29667508/fine-particulate-air-pollution-associated-with-increased-risk-of-hospital-admissions-for-hypertension-in-a-tropical-city-kaohsiung-taiwan
#1
Shang-Shyue Tsai, Chia-Ying Tsai, Chun-Yuh Yang
The aim of this study was to assess whether a correlation exists between fine particles (PM2.5 ) levels and number of hospital admissions for hypertension in Kaohsiung, Taiwan. Hospital admission frequency and ambient air pollution data were obtained for Kaohsiung for 2009-2013. A time-stratified case-crossover method was used to estimate relative risk for hospital admissions, controlling for weather, day of the week, seasonality, and long-term time trends. Odds ratios and 95% confidence intervals were calculated for a 10 µg/m3 increment of PM2...
April 18, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29667191/herbal-medicine-containing-aristolochic-acid-and-the-risk-of-hepatocellular-carcinoma-in-patients-with-hepatitis-b-virus-infection
#2
Chi-Jen Chen, Yao-Hsu Yang, Meng-Hung Lin, Chuan-Pin Lee, Yu-Tse Tsan, Ming-Nan Lai, Hsiao-Yu Yang, Wen-Chao Ho, Pau-Chung Chen
It was suspected that aristolochic acid-induced mutations may be associated with hepatitis B virus (HBV), playing an important role in liver carcinogenesis. The purpose of this study was to investigate the association between the use of Chinese herbs containing aristolochic acid and the risk of hepatocellular carcinoma (HCC) among HBV-infected patients. We conducted a retrospective, population-based, cohort study on patients older than 18 years who had a diagnosis of HBV infection between January 1, 1997 and December 31, 2010 and had visited traditional Chinese medicine clinics before one year before the diagnosis of HCC or the censor dates...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29666665/splenic-abscess-an-uncommon-entity-with-potentially-life-threatening-evolution
#3
Mei-Chun Lee, Chun-Ming Lee
Background/Purpose: Splenic abscess is rare with potentially life-threatening evolution. The aim of this study is to review the clinical features, microbiological etiologies, treatment, and outcomes of patients with splenic abscess. Methods: We reviewed the admitted patients with suspected splenic abscess and made the diagnosis of splenic abscess. The clinical characteristics, underlying diseases, treatment course, organism spectra, abscess number and size, therapeutic methods, and clinical outcome at a tertiary medical center in Taiwan over a period of 5 years were analyzed...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29666383/effect-of-antibiotic-use-for-acute-bronchiolitis-on-new-onset-asthma-in-children
#4
I-Lun Chen, Hsin-Chun Huang, Yu-Han Chang, Hsin-Yi Huang, Wei-Ju Yeh, Ting-Yi Wu, Jau-Ling Suen, San-Nan Yang, Chih-Hsing Hung
Early-life use of antibiotics is associated with asthma. We examined the effect of antibiotic use for early-life bronchiolitis on the development of new-onset asthma in children from Taiwan between 2005 and 2010. Data were from the National Health Insurance Research Database 2010, and diseases were coded using the International Classification of Disease (ICD). We classified the patients, all of whom had bronchiolitis, as having asthma or not having asthma. Asthma was diagnosed using ICD criteria and by use of an inhaled bronchodilator and/or corticosteroid twice in one year...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665984/emergency-department-overcrowding-quality-improvement-in-a-taiwan-medical-center
#5
Chen-Mei Hsu, Li-Lin Liang, Yun-Te Chang, Wang-Chuan Juang
BACKGROUND/PURPOSE: Overcrowding of hospital emergency departments (ED) is a worldwide health problem. The Taiwan Joint Commission on Hospital Accreditation has stressed the importance of finding solutions to overcrowding, including, reducing the number of patients with >48 h stay in the ED. Moreover, the Ministry of Health and Welfare aims at transferring non-critical patients to district or regional hospitals. We report the results of our Quality Improvement Project (QIP) on ED overcrowding, especially focusing on reducing length of stay (LOS) in ED...
April 14, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29665327/adjuvant-radiotherapy-and-chemotherapy-improve-survival-in-patients-with-pancreatic-adenocarcinoma-receiving-surgery-adjuvant-chemotherapy-alone-is-insufficient-in-the-era-of-intensity-modulation-radiation-therapy
#6
Mao-Chih Hsieh, Wei-Wen Chang, Hsin-Hsien Yu, Chang-Yun Lu, Chia-Lun Chang, Jyh-Ming Chow, Shee-Uan Chen, Yunfeng Cheng, Szu-Yuan Wu
In the era of intensity modulation radiation therapy (IMRT), no prospective randomized trial has evaluated the efficacy of adjuvant therapies such as adjuvant concurrent chemoradiotherapy (CCRT), adjuvant sequential chemotherapy and radiotherapy (CT-RT), and adjuvant CT alone in resectable pancreatic adenocarcinoma (PA). Through propensity score matching, we designed a nationwide, population-based, head-to-head cohort study to determine the effects of dissimilar adjuvant treatments on resectable PA. We minimized the confounding of various adjuvant treatment outcomes among the following resectable PA groups of patients from the Taiwan Cancer Registry database: group 1, adjuvant CCRT; group 2, adjuvant sequential CT-RT; and group 3, adjuvant CT alone...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29665069/generic-velpatasvir-plus-sofosbuvir-for-hepatitis-c-virus-infection-in-patients-with-or-without-human-immunodeficiency-virus-coinfection
#7
C-H Liu, H-Y Sun, C-J Liu, W-H Sheng, S-M Hsieh, Y-C Lo, W-C Liu, T-H Su, H-C Yang, C-M Hong, T-C Tseng, P-J Chen, D-S Chen, C-C Hung, J-H Kao
BACKGROUND: Data are limited regarding the effectiveness and safety of generic velpatasvir plus sofosbuvir (VEL/SOF) for hepatitis C virus (HCV) in patients with or without human immunodeficiency virus (HIV) coinfection. AIM: To evaluate the effectiveness and safety of generic VEL/SOF-based therapy for HCV infection in patients with or without HIV coinfection in Taiwan. METHODS: Sixty-nine HIV/HCV-coinfected and 159 HCV-monoinfected patients receiving 12 weeks of generic VEL/SOF with or without ribavirin (RBV) for HCV were prospectively enrolled...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29663342/associations-of-chronic-urticaria-with-atopic-and-autoimmune-comorbidities-a-nationwide-population-based-study
#8
Hsien-Yi Chiu, Chih-Hsin Muo, Fung-Chang Sung
BACKGROUND: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. OBJECTIVES: This study aims to examine the association between CU, and atopic and autoimmune diseases. METHODS: This population-based retrospective cohort study identified 9,332 patients with CU and 37,328 controls matched for age, sex, and number of dermatological clinic visits from the Taiwan National Health Insurance Research Database for 2004-2009...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29662662/health-effects-of-a-forest-environment-on-natural-killer-cells-in-humans-an-observational-pilot-study
#9
Tsung-Ming Tsao, Ming-Jer Tsai, Jing-Shiang Hwang, Wen-Fang Cheng, Chang-Fu Wu, Charles-C K Chou, Ta-Chen Su
Health effect assessments based on natural killer (NK) cells are an important emerging area of human health. We recruited 90 forest staff members in Xitou, Taiwan and 110 urban staff members in Taipei to investigate the health effects of forest environment exposure on NK cells (CD3- /CD56+ ) and activating NK cells (CD3- /CD56+ /CD69+ ) in humans. We also invited 11 middle-aged volunteers in a pilot study to participate in a five-day/four-night forest trip to Xitou forest to investigate the health effects of a forest trip on NK cells and activating NK cells...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662650/hdl-and-associated-factors-stratified-by-sex-and-menopausal-status-results-from-a-community-based-survey-in-taiwan
#10
Huan-Cheng Chang, Chuan-Fa Hsieh, Disline Manli Tantoh, Pei-Chieh Ko, Ya-Yu Kung, Mei-Chi Lin, Yi-Ching Liaw, Yung-Po Liaw
Aim: To investigate factors, especially modifiable factors associated with high-density lipoprotein (HDL) in Taiwanese based on sex and menopausal status. Materials and Methods: Participants comprised 2022 men and 2392 women (1267 menopausal and 1125 non-menopausal) aged ≥30 years who resided in Pingzhen district, Taoyuan from 2006-2011. Their data, obtained through questionnaires and measurements were retrieved from the Li-Shin Hospital. Results: Higher HDL was associated with total cholesterol, underweight, and alcohol drinking in both men and women...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662644/autoantibodies-against-islet-cell-antigens-in-children-with-type-1-diabetes-mellitus
#11
Bi-Wen Cheng, Fu-Sung Lo, An-Mei Wang, Chen-Mei Hung, Chi-Yu Huang, Wei-Hsin Ting, Mei-Ore Yang, Chao-Hsu Lin, Chia-Ching Chen, Chiung-Ling Lin, Yi-Lei Wu, Yann-Jinn Lee
We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by χ 2 test, binary logistic regression, and Spearman rank correlation. Of the 750 T1D patients, 66.3% had GADA, 65.3% IA2A, 35.7% IAA, and 17.2% no autoantibodies. The prevalence of GADA and IA2A significantly decreased along T1D duration...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662119/impact-of-diabetes-mellitus-on-the-risk-of-end-stage-renal-disease-in-patients-with-systemic-lupus-erythematosus
#12
Ming-Yan Jiang, Jyh-Chang Hwang, I-Jung Feng
Systemic lupus erythematosus (SLE) patients are associated with insulin resistance and are at higher risk to develop diabetes mellitus (DM). SLE and DM could lead to renal failure respectively. However, it is unknown whether DM increases the risk of end-stage renal disease (ESRD) in SLE patients. This study aimed to evaluate potential synergistic effect of DM on SLE patients for development of ESRD. We conducted this study by using National Health Insurance Research Database of Taiwan. We recruited SLE patients with newly-diagnosed DM as the study cohort...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661770/hydroxychloroquine-use-and-risk-of-ckd-in-patients-with-rheumatoid-arthritis
#13
Chia-Lin Wu, Chia-Chu Chang, Chew-Teng Kor, Tao-Hsiang Yang, Ping-Fang Chiu, Der-Cherng Tarng, Chih-Cheng Hsu
BACKGROUND AND OBJECTIVES: Hydroxychloroquine is widely used in patients with rheumatoid arthritis. However, large-scale studies examining the long-term effects of hydroxychloroquine on the development of kidney disease in patients with rheumatoid arthritis are lacking. We aimed to assess the long-term association of hydroxychloroquine use with the risk of developing CKD in this population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted an observational cohort study for patients with newly diagnosed rheumatoid arthritis who were enrolled prospectively in Taiwan's National Health Insurance Research Database between January 1, 2000 and December 31, 2013...
April 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29661569/analysis-of-gwas-linked-variants-in-multiple-system-atrophy
#14
XiaoJing Gu, YongPing Chen, QingQing Zhou, Ying-Che Lu, Bei Cao, LingYu Zhang, Ming-Che Kuo, Yih-Ru Wu, Ruey-Meei Wu, Eng-King Tan, Hui-Fang Shang
A recent genome-wide association study performed in European population identified 4 potentially interesting gene loci of multiple system atrophy (MSA), including the EDN1 rs16872704, MAPT rs9303521, FBXO47 rs78523330, and ELOVL7 rs7715147. Because of the genetic heterogeneity, we aimed to explore the possible genetic association between above 4 single nucleotide polymorphisms (SNPs) and MSA in Chinese Han population from Mainland China, Taiwan, and Singapore. A total of 1847 subjects comprising 906 MSA patients and 941 unrelated healthy controls were genotyped by directly sequencing for these SNPs...
March 23, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29661488/psychometric-evaluation-of-the-whoqol-bref-taiwan-version-across-five-kinds-of-taiwanese-cancer-survivors-rasch-analysis-and-confirmatory-factor-analysis
#15
Chung-Ying Lin, Jing-Shiang Hwang, Wen-Chung Wang, Wu-Wei Lai, Wu-Chou Su, Tzu-Yi Wu, Grace Yao, Jung-Der Wang
BACKGROUND: Quality of life (QoL) is important for clinicians to evaluate how cancer survivors judge their sense of well-being, and WHOQOL-BREF may be a good tool for clinical use. However, at least three issues remain unresolved: (1) the psychometric properties of the WHOQOL-BREF for cancer patients are insufficient; (2) the scoring method used for WHOQOL-BREF needs to be clarify; (3) whether different types of cancer patients interpret the WHOQOL-BREF similarly. METHODS: We recruited 1000 outpatients with head/neck cancer, 1000 with colorectal cancer, 965 with liver cancer, 1438 with lung cancer and 1299 with gynecologic cancers in a medical center...
April 13, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29660933/medical-comorbidity-in-alzheimer-s-disease-a-nested-case-control-study
#16
Jen-Hung Wang, Ya-Ju Wu, Boon Lead Tee, Raymond Y Lo
BACKGROUND: Little is known about the distribution of medical comorbidities in Alzheimer's disease (AD). OBJECTIVE: We aimed to describe the comorbidity pattern of AD in a nested case-control study. METHODS: Incident AD cases were identified by International Classification of Diseases codes in a random sample of 2 million individuals in Taiwan National Health Insurance program during 2001-2011. We further restricted cases to those treated with AD drugs of approved reimbursement...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29660754/antidepressant-prescription-and-risk-of-lung-cancer-a-nationwide-case-control-study
#17
Chia-Jui Tsai, Wei-Che Chiu, Chia-Ju Chen, Pau-Chung Chen, Roger S McIntyre, Vincent Chin-Hung Chen
INTRODUCTION: In recent decades, concern about safety of antidepressants has been raised but the risk between antidepressants and lung cancer has not yet been established. METHODS: A case-control study was conducted by using a nationwide database in Taiwan. The case groups were new onset lung cancer diagnosis during 1999-2008 and age- and gender-matched controls were selected among those without any cancer. The cumulative exposure dose before the lung cancer diagnosis was added and risks were calculated according to the levels of defined daily dose and classes of antidepressants...
April 16, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29660574/the-effectiveness-of-learning-portfolios-in-learning-participation-and-learners-perceptions-of-skills-and-confidence-in-the-mother-of-preterm-infant
#18
Yi-Chuan Cheng, Li-Li Chen, Yu-Shan Chang, Tsai-Chung Li, Ching-Ju Chen, Li-Chi Huang
OBJECTIVE: The purpose of this study was to investigate the effectiveness of preterm infant learning portfolios in enabling mothers to develop infant care knowledge and skills, as well as confidence in their abilities. DESIGN: This study used a quasi-experimental design. SETTING AND PARTICIPANTS: The sample consisted of 52 mothers with preterm infants recruited at a neonatal intermediate unit of a medical centre in central Taiwan. Among those, 26 participants in the control group received regular health education and 26 participants in the experimental group received learning portfolios and regular care...
March 22, 2018: Midwifery
https://www.readbyqxmd.com/read/29660219/hepatitis-b-virus-infection-in-taiwan-the-role-of-ntcp-rs2296651-variant-in-relation-to-sex
#19
Oswald Ndi Nfor, Ming-Fang Wu, Tonmoy Debnath, Chun-Te Lee, Wang Lee, Wen-Hsiu Liu, Disline Manli Tantoh, Shu-Yi Hsu, Yung-Po Liaw
Sodium taurocholate co-transporting polypeptide (NTCP) is a functional receptor for hepatitis B virus infection. NTCP rs2296651 is believed to be an Asian-specific variant responsible for HBV susceptibility. We investigated the relationship between rs2296651 and HBV infection in Taiwan based on stratification by gender and menopausal status. We recruited 10017 Taiwan Biobank participants aged 30-70 years with complete genetic data and sociodemographic information. Gender-stratified multivariate logistic regression models were used to determine the relationship between NTCP variant and HBV infection...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29659167/the-bidirectional-association-among-female-hormone-related-cancers-breast-ovary-and-uterine-corpus
#20
Min-Chi Chen, Kuan-Der Lee, Chang-Hsien Lu, Ting-Yao Wang, Shih-Hao Huang, Chao-Yu Chen
Breast, ovarian, and uterine corpus cancers are common female cancers and categorized as hormone-related diseases. Previous studies reported a unidirectional relationship for each cancer, but few studied the reciprocal association in the same cohort. A population-based study was carried out in Taiwan to test the hypothesis that there are pairwise bidirectional associations among these cancers. Using the same cohort of 110,112 cases with primary female cancers including uterine corpus cancer (11,146 cases), ovarian cancer (12,139 cases), or breast cancer (86,827 cases) from the Taiwan Cancer Registry from 1979 to 2008, the pairwise risks of second cancer among uterine corpus, ovary, and breast cancer cases were evaluated by standardized incidence ratios (SIRs) and the corresponding 95% confidence intervals (CIs) to quantify the excess of second malignancies...
April 16, 2018: Cancer Medicine
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