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https://www.readbyqxmd.com/read/29458119/the-function-of-hla-b-13-01-involved-in-the-pathomechanism-of-dapsone-induced-severe-cutaneous-adverse-reactions
#1
Wei-Ti Chen, Chuang-Wei Wang, Chun-Wei Lu, Chun-Bing Chen, Hua-En Lee, Shuen-Iu Hung, Siew-Eng Choon, Chih-Hsun Yang, Ming-Tsan Liu, Ting Jui Chen, Wen-Lang Fan, Shih-Chi Su, Yang Yu-Wei Lin, Ya-Ching Chang, Wen-Hung Chung
Dapsone-induced hypersensitivity reactions may cause severe cutaneous adverse reactions (SCAR), such as drug reaction with eosinophilia and systemic symptoms (DRESS). It has been reported that HLA-B*13:01 is strongly associated with dapsone-induced hypersensitivity reactions among leprosy patients. However, the phenotype specificity and detailed immune mechanism of HLA-B*13:01 remains unclear. We investigated the genetic predisposition, HLA-B*13:01 function, and cytotoxic T cells (CTLs) involved in pathogenesis of dapsone-SCAR...
February 16, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#2
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29456827/impairment-of-social-behaviors-in-arhgef10-knockout-mice
#3
Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau, Wen-Mei Fu
Background: Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the genes included in the deleted region is ARHGEF10 . A missense mutation of ARHGEF10 has been reported to be one of the contributing factors in several diseases of the central nervous system. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29456496/how-do-acquired-political-identities-influence-our-neural-processing-toward-others-within-the-context-of-a-trust-game
#4
Chien-Te Wu, Yang-Teng Fan, Ye-Rong Du, Tien-Tun Yang, Ho-Ling Liu, Nai-Shing Yen, Shu-Heng Chen, Ray-May Hsung
Trust is essential for mutually beneficial human interactions in economic exchange and politics and people's social identities notably have dramatic effects on trust behaviors toward others. Previous literature concerning social identities generally suggests that people tend to show in-group favoritism toward members who share the same identity. However, how our brains process signals of identity while facing uncertain situations in interpersonal interactions remains largely unclear. To address this issue, we performed an fMRI experiment with 54 healthy adults who belonged to two identity groups of opposing political orientations...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29456079/phase-iv-randomized-clinical-study-peginterferon-alfa-2a-with-adefovir-or-entecavir-pre-therapy-for-hbeag-positive-chronic-hepatitis-b
#5
Chao-Wei Hsu, Wei-Wen Su, Chuan-Mo Lee, Cheng-Yuan Peng, Wan-Long Chuang, Jia-Horng Kao, Heng-Cheng Chu, Yi-Hsiang Huang, Rong-Nan Chien, Yun-Fan Liaw
BACKGROUND: Efficacy of sequential therapy with nucleos(t)ide analogues and interferons versus monotherapy in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) remains unexplored. We aimed to assess efficacy and safety of sequential therapy with adefovir (ADV) or entecavir (ETV) followed by peginterferon (PEG-IFN) alfa-2a in Taiwanese patients with HBeAg-positive. METHODS: This randomized, placebo-controlled, double-blind trial was conducted at nine sites in Taiwan from April 2010 to October 2013...
February 15, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29456028/polyphasic-characterization-of-a-novel-species-in-the-lactobacillus-casei-group-from-cow-manure-of-taiwan-description-of-l-chiayiensis-sp-nov
#6
Chien-Hsun Huang, Jong-Shian Liou, Ai-Yun Lee, Min Tseng, Mika Miyashita, Lina Huang, Koichi Watanabe
Two Gram-stain-positive, rod-shaped, non-motile, catalase-negative and facultative anaerobic strains, NCYUAST and BCRC 18859 (=NRIC 1947), were isolated from cow manure of Taiwan and coconut juice of Philippines, respectively. Comparative sequence analysis of 16S rRNA gene revealed that the novel strains were members of the genus Lactobacillus. These two strains had 100% of 16S rRNA gene sequence similarity and 98.6% of average nucleotide identity (ANI) value based on whole genome sequences. On the basis of 16S rRNA gene sequence similarity, the type strains of Lactobacillus casei (99...
February 7, 2018: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29455340/an-international-clinical-study-of-ability-and-disability-in-adhd-using-the-who-icf-framework
#7
Soheil Mahdi, Nadia Ronzano, Ane Knüppel, José Carlos Dias, Ayman Albdah, Lin Chien-Ho, Omar Almodayfer, Annet Bluschke, Sunil Karande, Huei-Lin Huang, Hanna Christiansen, Mats Granlund, Petrus J de Vries, David Coghill, Rosemary Tannock, Luis Rohde, Sven Bölte
This is the fourth and final study designed to develop International Classification of Functioning, Disability and Health (ICF, and children and youth version, ICF-CY) core sets for attention-deficit hyperactivity disorder (ADHD). To investigate aspects of functioning and environment of individuals with ADHD as documented by the ICF-CY in clinical practice settings. An international cross-sectional multi-centre study was applied, involving nine units from eight countries: Denmark, Germany, India, Italy, Portugal, Saudi Arabia, Sweden and Taiwan...
February 17, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29454513/outcomes-and-related-factors-in-a-cohort-of-infants-born-in-taiwan-over-a-period-of-five-years-2007-2011-with-borderline-viability
#8
Jui-Hsing Chang, Chyong-Hsin Hsu, Kao-Inn Tsou, Wai-Tim Jim
BACKGROUND: Advances in perinatal and neonatal care have increased the survival of extremely preterm infants, but the viability limit is still debated. Here we assess the survival, neonatal morbidity, and neurodevelopmental outcomes at 2 years of age of infants born at 22-26 weeks of gestation in Taiwan between 2007 and 2011. METHODS: This is a prospective longitudinal multicenter cohort study on extremely preterm infants registered in the Taiwan Premature Infant Developmental Collaborative Study Group from 2007 to 2011, including 22 neonatal care centers...
February 14, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29454071/hla-in-north-colombia-chimila-amerindians
#9
Antonio Arnaiz-Villena, Jose Palacio-Grüber, Ignacio Juarez, Ennio Hernández, Ester Muñiz, Brayan Bayona, Cristina Campos, Jorge Nieto, Manuel Martin-Villa, Carlos Silvera
HLA-A,-B,-C-DRB1 and -DQB1 alleles have been studied in Chimila Amerindians from Sabana de San Angel (North Colombian Coast) by using high resolution molecular typing.A frequent extended haplotype was found:HLA-A∗24:02-B∗51:10-C∗15:02-BRB1∗04:07-DQB1∗03:02 (28.7%) which has also been described in Amerinndian Mayos Mexican population (Mexico,California Gulf,Pacific Ocean),Other haplotypae had already been found in Amerindians from Mexico (Pacific and Atlantic Coast),Peru (highlands and Amazon Basin),Bolivia and North USA...
February 14, 2018: Human Immunology
https://www.readbyqxmd.com/read/29453297/what-factors-mediate-the-inter-relationship-between-frailty-and-pain-in-cognitively-and-functionally-sound-older-adults-a-prospective-longitudinal-ageing-cohort-study-in-taiwan
#10
Jing-Hui Chiou, Li-Kuo Liu, Wei-Ju Lee, Li-Ning Peng, Liang-Kung Chen
OBJECTIVES: The main aim was to investigate the complex inter-relationship between frailty and pain, and the mediating roles of cognitive function, morbidity and mood in this nexus. DESIGN: A cross-sectional analysis. SETTING: A prospective community-dwelling population-based cohort. PARTICIPANTS: 1682 adults age ≥50 years without evident cognitive or functional impairment, or history of cancer. PRIMARY AND SECONDARY OUTCOME MEASURES: The mediating effect of depression, cognitive function and comorbidity on the nexus between pain and frailty among older and middle-aged adults...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453020/2018-consensus-of-the-taiwan-society-of-cardiology-and-the-diabetes-association-of-republic-of-china-taiwan-on-the-pharmacological-management-of-patients-with-type-2-diabetes-and-cardiovascular-diseases
#11
Chern-En Chiang, Shih-Yi Lin, Tsung-Hsien Lin, Tzung-Dau Wang, Hung-I Yeh, Jung-Fu Chen, Chia-Ti Tsai, Yi-Jen Hung, Yi-Heng Li, Ping-Yen Liu, Kuan-Cheng Chang, Kang-Ling Wang, Ting-Hsing Chao, Kou-Gi Shyu, Wei-Shiung Yang, Kwo-Chang Ueng, Pao-Hsien Chu, Wei-Hsian Yin, Yen-Wen Wu, Hao-Min Cheng, Shyi-Jang Shin, Chien-Ning Huang, Lee-Ming Chuang, Shing-Jong Lin, San-Jou Yeh, Wayne Huey-Herng Sheu, Jiunn-Lee Lin
The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). About two-thirds of death in type 2 diabetes are due to ASCVD, including 40% from coronary heart disease (CHD), 15% from heart failure (HF), and 10% from stroke. The association between hyperglycemia and elevated CV risk has been demonstrated in multiple cohort studies. However, clinical trials of intensive glucose reduction did not significantly reduce macrovascular outcomes...
February 13, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29452320/the-risk-of-traumatic-brain-injury-occurring-among-patients-with-parkinson-sdisease-a-14-year-population-based-study
#12
Tee-Tau Eric Nyam, Chung-Han Ho, Yu-Lin Wang, Sher-Wei Lim, Jhi-Joung Wang, Chung-Ching Chio, Jinn-Rung Kuo, Che-Chuan Wang
BACKGROUND: Previous studies have implicated traumatic brain injury (TBI) as a risk factor for Parkinson's disease (PD). However, the incidence risk of new-onset TBI among patients with PD is not well established. This study investigated the contribution of PD to new-onset TBI associations. MATERIAL AND METHODS: The study selected 6,076 patients with PD and using 1:2 propensity score matching 12,152 general population cohorts in a longitudinal population database in Taiwan...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451326/evaluation-of-factors-contributing-to-the-decline-in-exclusive-breastfeeding-at-6-months-postpartum-the-2011-2016-national-surveys-in-taiwan
#13
Alexander Waits, Chao-Yu Guo, Li-Yin Chien
BACKGROUND: Since 1992, breastfeeding promotion in Taiwan considerably raised the breastfeeding rates; however, more recent surveillance showed that breastfeeding indicators stagnated or even decreased. METHODS: We analyzed 6 cross-sectional national surveys of 69 159 postpartum women to examine the breastfeeding trends at 6 months postpartum during 2011-2016 in Taiwan and the contributing role of maternal and environmental factors. Data were collected through telephone interviews, using structured questionnaires with randomly selected mothers, who gave birth in those years...
February 16, 2018: Birth
https://www.readbyqxmd.com/read/29451184/the-long-term-outcomes-of-cirrhotic-patients-with-pleural-effusion
#14
Tsung-Hsing Hung, Chih-Wei Tseng, Chih-Chun Tsai, Chen-Chi Tsai, Kuo-Chih Tseng, Yu-Hsi Hsieh
Background/Aim: A pleural effusion is an abnormal collection of fluid in the pleural space and may cause related morbidity or mortality in cirrhotic patients. Currently, there are insufficient data to support the long-term prognosis for cirrhotic patients with pleural effusion. In this study, we investigated the short- and long-term effects of pleural effusion on mortality in cirrhotic patients and evaluated the benefit of liver transplantation in these patients. Patients and Methods: The National Health Insurance Database, derived from the Taiwan National Health Insurance Program, was used to identify 3,487 cirrhotic patients with pleural effusion requiring drainage between January 1, 2007 and December 31, 2010...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29450827/progression-free-survival-results-in-postmenopausal-asian-women-subgroup-analysis-from-a-phase-iii-randomized-trial-of-fulvestrant-500-mg-vs-anastrozole-1-mg-for-hormone-receptor-positive-advanced-breast-cancer-falcon
#15
Shinzaburo Noguchi, Matthew J Ellis, John F R Robertson, Jackie Thirlwell, Mehdi Fazal, Zhimin Shao
BACKGROUND: The international, phase III FALCON study (NCT01602380) in postmenopausal patients with hormone receptor-positive, locally advanced/metastatic breast cancer (LA/MBC) who had not received prior endocrine therapy, demonstrated statistically significant improvement in progression-free survival (PFS) for patients who received fulvestrant 500 mg vs anastrozole 1 mg. This subgroup analysis evaluated PFS in Asian (randomized in China, Japan, or Taiwan) and non-Asian patients from the FALCON study...
February 15, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29450504/association-of-adenotonsillectomy-with-blood-pressure-among-hypertensive-and-nonhypertensive-children-with-obstructive-sleep-apnea
#16
Cho-Hsueh Lee, Kun-Tai Kang, Shuenn-Nan Chiu, I-Sheng Chang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Importance: Hypertension in childhood may continue into adulthood and lead to adverse cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement. However, how adenotonsillectomy is associated with BP in hypertensive and nonhypertensive children with OSA remains unclear. Objective: To investigate disparities in BP changes after adenotonsillectomy in hypertensive and nonhypertensive children with OSA...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29449860/adaptive-genetic-divergence-despite-significant-isolation-by-distance-in-populations-of-taiwan-cow-tail-fir-keteleeria-davidiana-var-formosana
#17
Kai-Ming Shih, Chung-Te Chang, Jeng-Der Chung, Yu-Chung Chiang, Shih-Ying Hwang
Double digest restriction site-associated DNA sequencing (ddRADseq) is a tool for delivering genome-wide single nucleotide polymorphism (SNP) markers for non-model organisms useful in resolving fine-scale population structure and detecting signatures of selection. This study performs population genetic analysis, based on ddRADseq data, of a coniferous species, Keteleeria davidiana var. formosana , disjunctly distributed in northern and southern Taiwan, for investigation of population adaptive divergence in response to environmental heterogeneity...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29449166/clinical-characteristics-and-treatment-outcomes-of-pulmonary-invasive-fungal-infection-among-adult-patients-with-hematological-malignancy-in-a-medical-centre-in-taiwan-2008-2013
#18
Chien-Yuan Chen, Wang-Huei Sheng, Feng-Ming Tien, Po-Chu Lee, Shang-Yi Huang, Jih-Luh Tang, Woei Tsay, Hwei-Fang Tien, Po-Ren Hsueh
BACKGROUND/PURPOSE: This study was aimed to investigate clinical characteristics and treatment outcomes of pulmonary invasive fungal infection (IFI) among patients with hematological malignancy. METHODS: All patients with hematological malignancy who were treated at a medical centre from 2008 to 2013 were evaluated. Pulmonary IFI was classified according to the European Organization for Research and Treatment of Cancer 2008 consensus. RESULTS: During the study period, 236 (11...
January 31, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29447362/eq-5d-y-for-the-assessment-of-health-related-quality-of-life-among-taiwanese-youth-with-mild-to-moderate-chronic-kidney-disease
#19
Chien-Ning Hsu, Hsiang-Wen Lin, A Simon Pickard, You-Lin Tain
Objective: To assess if health-related quality of life (HRQOL) of children with chronic kidney disease (CKD) and different comorbid conditions can be identified based on the EQ-5D child-friendly version (EQ-5D-Y). Design: Prospective cross-sectional study. Setting: A tertiary care medical center in Taiwan. Study participants: All CKD patients aged 7-18 years treated at the center between May 2014 and December 2016. Main Outcome Measures: HRQOL assessment was done using EQ-5D-Y...
February 13, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29447190/the-incidence-and-factors-of-hip-fractures-and-subsequent-morbidity-in-taiwan-an-11-year-population-based-cohort-study
#20
Kai-Biao Lin, Nan-Ping Yang, Yi-Hui Lee, Chien-Lung Chan, Chi-Hsu Wu, Hou-Chuan Chen, Nien-Tzu Chang
Hip fractures are a major problem to elder population, but subsequent morbidity is unclear about environmental factors and socioeconomic conditions. The study aims to investigate the incidence of hip fractures treated by the surgery; to compare the sequelae and temporal trends of hip fractures; to evaluate the seasonal effects in the subsequent short-term and long-term morbidities after hip fractures. A cohort study design is conducted using national health research datasets between 2000 and 2010. The ICD-9-CM diagnostic codes were utilized to investigate the incidence of hip fractures and the corresponding treatments...
2018: PloS One
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