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https://www.readbyqxmd.com/read/29227965/human-longevity-25-genetic-loci-associated-in-389-166-uk-biobank-participants
#1
Luke C Pilling, Chia-Ling Kuo, Kamil Sicinski, Jone Tamosauskaite, George A Kuchel, Lorna W Harries, Pamela Herd, Robert Wallace, Luigi Ferrucci, David Melzer
We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10-8), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mothers age ≥90 years, fathers ≥87 years), with 2 additional associations including MC2R intronic variants (coding for the adrenocorticotropic hormone receptor)...
December 6, 2017: Aging
https://www.readbyqxmd.com/read/29227838/financial-strain-indirectly-influences-smoking-cessation-through-withdrawal-symptom-severity
#2
Darla E Kendzor, Michael S Businelle, Aaron F Waters, Summer G Frank, Emily T Hébert
BACKGROUND: Financial strain has an adverse impact on smoking cessation. However, the mechanisms through which financial strain influences cessation remain unclear. The purpose of the current study was to determine whether financial strain indirectly influenced smoking cessation through withdrawal symptom severity. METHODS: Participants (N=139) were primarily Black (63.3%) and female (57.6%) adults enrolled in a smoking cessation program at a safety-net hospital...
December 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29226867/an-objective-method-to-accurately-measure-cardiorespiratory-fitness-in-older-adults-who-cannot-satisfy-widely-used-oxygen-consumption-criteria
#3
Ryan J Dougherty, Jacob B Lindheimer, Aaron J Stegner, Stephanie Van Riper, Ozioma C Okonkwo, Dane B Cook
Cardiorespiratory fitness (CRF) is routinely investigated in older adults; however, the most appropriate CRF measure to use for this population has received inadequate attention. This study aimed to 1) evaluate the reliability and validity of the oxygen uptake efficiency slope (OUES) as a sub-maximal measurement of CRF; 2) examine demographic, risk-factor, and exercise testing differences in older adults who satisfied standardized criteria for a peak oxygen consumption (V̇O2peak) test compared to those who did not; and 3) determine the difference between directly measured V̇O2peak values and OUES-predicted V̇O2peak values...
December 6, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29221671/population-based-risk-factors-for-shoulder-dystocia
#4
Palmira Santos, Jennifer Gaudet Hefele, Grant Ritter, Jennifer Darden, Cassandra Firneno, Ann Hendrich
OBJECTIVE: To re-examine the risk factors for shoulder dystocia given the increasing rates of obesity and diabetes in pregnant women. DESIGN: Retrospective observational study. SETTING: Five hospitals located in Wisconsin, Florida, Maryland, Michigan, and Alabama. PARTICIPANTS: We evaluated 19,236 births that occurred between April 1, 2011, and July 25, 2013. METHODS: Data were collected from electronic medical records and used to evaluate the risk of shoulder dystocia...
December 5, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29220523/interviewers-ratings-of-respondents-health-predictors-and-association-with-mortality
#5
Dana Garbarski, Nora Cate Schaeffer, Jennifer Dykema, Deborah Carr
Objectives: Recent research indicates that survey interviewers' ratings of respondents' health (IRH) may provide supplementary health information about respondents in surveys of older adults. Although IRH is a potentially promising measure of health to include in surveys, our understanding of the factors contributing to IRH remains incomplete. Methods: We use data from the 2011 face-to-face wave of the Wisconsin Longitudinal Study, a longitudinal study of older adults from the Wisconsin high school class of 1957 and their selected siblings...
December 6, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29217789/genome-sequences-of-19-rhodococcus-erythropolis-cluster-ca-phages
#6
J Alfred Bonilla, Sharon Isern, Ann M Findley, Karen K Klyczek, Scott F Michael, Margaret S Saha, William J Buchser, Mark H Forsyth, Sudip Paudel, Christopher R Gissendanner, Allison M D Wiedemeier, Fernanda L Alonzo, Rebecca A Garlena, Daniel A Russell, Welkin H Pope, Steven G Cresawn, Deborah Jacobs-Sera, Graham F Hatfull
We report the complete genome sequences of 19 cluster CA bacteriophages isolated from environmental samples using Rhodococcus erythropolis as a host. All of the phages are Siphoviridae, have similar genome lengths (46,314 to 46,985 bp) and G+C contents (58.5 to 58.8%), and share nucleotide sequence similarity.
December 7, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29214316/association-between-hospital-financial-distress-and-immediate-breast-reconstruction-surgery-after-mastectomy-among-women-with-ductal-carcinoma-in-situ
#7
Catherine A Richards, Andrew G Rundle, Jason D Wright, Dawn L Hershman
Importance: Hospital financial distress (HFD) is a state in which a hospital is at risk of closure because of its financial condition. Hospital financial distress may reduce the services a hospital can offer, particularly unprofitable ones. Few studies have assessed the association of HFD with quality of care. Objective: To examine the association between HFD and receipt of immediate breast reconstruction surgery after mastectomy among women diagnosed with ductal carcinoma in situ (DCIS)...
December 6, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29212459/acquisition-and-persistence-of-strain-specific-methicillin-resistant-staphylococcus-aureus-and-their-determinants-in-community-nursing-homes
#8
Nataliya G Batina, Christopher J Crnich, Dörte Döpfer
BACKGROUND: Nursing home residents are frequently colonized with various strains of methicillin-resistant Staphylococcus aureus (MRSA) but the intra-facility dynamics of strain-specific MRSA remains poorly understood. We aimed at identifying and quantifying the associations between acquisition and carriage of MRSA strains and their potential risk factors in community nursing homes using mathematical modeling. METHODS: The data was collected during a longitudinal MRSA surveillance study in six nursing homes in South Central Wisconsin...
December 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29212133/factors-associated-with-patient-reported-procedural-memory-following-emergency-department-procedural-sedation-with-ketamine-and-propofol-a-prospective-cohort-of-563-patients
#9
Andrew Greer, Greg Treston
OBJECTIVES: To describe the proportion of patients reporting procedural memory following procedural sedation and analgesia (PSA) with ketamine and propofol (KP) administered premixed together (ketofol) or individually (sequential KP) in ED attendees. Identify any clinical or demographic variables associated with procedural memory. METHODS: This was a convenience sample of 563 patients who received KP PSA as per the departmental protocol. A standardised script was used to assess for procedural memory...
December 6, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29209876/mentalization-deficit-in-bipolar-patients-during-an-acute-depressive-and-manic-episode-association-with-cognitive-functions
#10
Anna Bodnar, Janusz K Rybakowski
BACKGROUND: A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective mentalization in well-defined groups of depressed and manic bipolar patients, compared to healthy control subjects, using a battery of tests measuring mentalization processes. The second aim was to investigate a possible relationship between cognitive and affective mentalization and cognitive functions in bipolar patients during a depressive and manic episode...
December 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29206134/variable-isotopic-compositions-of-host-plant-populations-preclude-assessment-of-aphid-overwintering-sites
#11
Michael S Crossley, Shawn A Steffan, David J Voegtlin, Krista L Hamilton, David B Hogg
Soybean aphid (Aphis glycines Matsumura) is a pest of soybean in the northern Midwest whose migratory patterns have been difficult to quantify. Improved knowledge of soybean aphid overwintering sites could facilitate the development of control efforts with exponential impacts on aphid densities on a regional scale. In this preliminary study, we explored the utility of variation in stable isotopes of carbon and nitrogen to distinguish soybean aphid overwintering origins. We compared variation in bulk 13C and 15N content in buckthorn (Rhamnus cathartica L...
December 5, 2017: Insects
https://www.readbyqxmd.com/read/29204943/occurrence-distribution-and-composition-of-aliphatic-and-polycyclic-aromatic-hydrocarbons-in-sediment-cores-from-the-lower-fox-river-wisconsin-us
#12
Chase S Brewster, Virender K Sharma, Leslie Cizmas, Thomas J McDonald
The Lower Fox River is a 39 mile section which supports approximately 270,000 rural inhabitants across 18 counties, 303,000 metropolitan residents in Green Bay and Appleton, Wisconsin, and several large industrial complexes such as paper mills and power plants. This paper presents the distribution and concentrations of aliphatic (n-alkanes) and aromatic hydrocarbons (polycyclic aromatic hydrocarbons [PAHs]) as well as total organic carbon (TOC) in the Lower Fox River to identify the sources of hydrocarbon contamination...
December 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29204808/implementing-a-virtual-health-telemedicine-program-in-a-community-setting
#13
Scott M Weissman, Kate Zellmer, Nicole Gill, Deborah Wham
Aurora Health Care in eastern Wisconsin has a clinical genetics program driven by genetic counselors in the cancer/adult and prenatal genetics settings. In 2015, the workforce shortage of genetic counselors left us with 4 open positions for genetic counselors that we were unable to fill. We explored many models of alternative service delivery, and determined virtual health (VH) via telemedicine to be the best option for our system. Historically, telemedicine technologies have been used to provide access to healthcare services to patients in remote areas...
December 4, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29198186/screening-in-trauma-for-opioid-misuse-prevention-stomp-study-protocol-for-the-development-of-an-opioid-risk-screening-tool-for-victims-of-injury
#14
Randall Brown, Brienna Deyo, Chelsea Riley, Andrew Quanbeck, Joseph E Glass, Rebecca Turpin, Scott Hetzel, Christopher Nicholas, Maireni Cruz, Suresh Agarwal
BACKGROUND: Opioid addiction and overdose are epidemic in the U.S. Victims of traumatic injury are at greater than average risk for opioid misuse and related complications. Potential risk screens and preventive interventions in this clinical population remain under-investigated. The current project seeks to develop and pilot the implementation of a screening tool for opioid risk at American College of Surgeons (ACS) Level I and Level II trauma centers. METHODS: The project began with an online survey, which was sent to Wisconsin trauma center medical directors and trauma coordinators for the purpose of gathering information on current substance use screening practices...
December 4, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29194059/self-reported-mild-traumatic-brain-injuries-in-relation-to-rumination-and-depressive-symptoms-moderating-role-of-sex-differences-and-a-brain-derived-neurotrophic-factor-gene-polymorphism
#15
Robert L Gabrys, Kaylyn Dixon, Matthew R Holahan, Hymie Anisman
OBJECTIVE: Mild traumatic brain injuries (mTBIs) have frequently been associated with the emergence and persistence of depressive symptoms. However, the factors which contribute to the increased risk for depression after these head injuries remain unclear. Accordingly, we examined the relationship between frequency of self-reported mTBIs and current symptoms of depression and the mediating role of rumination and cognitive flexibility. We also examined whether these relations were moderated by sex differences and the presence of the Val66Met polymorphism in a gene coding for brain-derived neurotrophic factor (BDNF)...
November 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29192947/-executive-functions-in-frontal-lob-syndrome-a-case-report
#16
Özge Metin, Ali Evren Tufan, Nagihan Cevher Binici, Özge Saraçlı, Adnan Atalay, Ayşegül Yolga Tahiroğlu
Prefrontal cortex in frontal lobe (FL) is the center of executive functions (EF). FL damage can lead to executive dysfunction by influencing frontal-subcortical circuits (dorsolateral, orbitofrontal, ventromedial). Damage to the dorsolateral prefrontal cortex (DLPFC) can lead to deterioration in EF, whereas damage to the orbitofrontal cortex (OFC) can lead to personality changes with the characteristic of disinhibition and irritability. In addition, damage to the anterior cingulate cortex/medial prefrontal cortex (ACC/MPFC) can result in decreased spontaneity...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29191715/vcr-cvad-induction-chemotherapy-followed-by-maintenance-rituximab-produces-durable-remissions-in-mantle-cell-lymphoma-a-wisconsin-oncology-network-study
#17
Julie E Chang, Lakeesha L Carmichael, KyungMann Kim, Christopher Peterson, David T Yang, Anne M Traynor, Jae E Werndli, Michael S Huie, Thomas A McFarland, Michael Volk, Jules Blank, Natalie S Callander, Walter L Longo, Brad S Kahl
INTRODUCTION: VcR-CVAD was developed as an intermediate-intensity induction regimen with maintenance rituximab (MR) to improve remission durations after first-line therapy for mantle cell lymphoma (MCL) in older and younger patients with MCL. PATIENTS AND METHODS: Patients with previously untreated MCL received VcR-CVAD induction chemotherapy for 6 cycles (21-day cycles). Patients achieving at least a partial response received rituximab consolidation (375 mg/m2 × 4 weekly doses) and MR (375 mg/m2 every 12 weeks × 20 doses)...
November 4, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29189258/the-use-of-smoothelin-and-other-antibodies-in-the-diagnosis-of-uterine-and-soft-tissue-smooth-muscle-tumors
#18
Kim Greg Mayhall, Estelle Oertling, Eleanor Lewin, John Schmieg, Helena LeBeau, Tong Wu, Byron Crawford
Smoothelin is a cytoplasmic protein expressed in differentiated smooth muscle cells. Immunohistochemical evaluation of smoothelin has previously been reported in gastrointestinal (GI) smooth muscle tumors, but has yet to be studied in smooth muscle tumors of uterine and other soft tissue origin. DOG1 expression is reported to be specific for GI stromal tumors; however, variable expression has been reported in leiomyosarcomas (LMS) depending on site of origin. Overexpression of p16 is common in LMS of uterine and other sites of origin, but has not been correlated with tumor grade...
November 20, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29186313/the-latent-structure-and-test-retest-stability-of-connected-language-measures-in-the-wisconsin-registry-for-alzheimer-s-prevention-wrap
#19
Kimberly D Mueller, Rebecca L Koscik, Lindsay R Clark, Bruce P Hermann, Sterling C Johnson, Lyn S Turkstra
Introduction: While it is well known that discourse-related language functions are impaired in the dementia phase of Alzheimer's Disease (AD), the presymptomatic temporal course of discourse dysfunction are not known earlier in the course of AD. To conduct discourse-related studies in this phase of AD, validated psychometric instruments are needed. This study investigates the latent structure, validity, and test-retest stability of discourse measures in a late-middle-aged normative group who are relatively free from sporadic AD risk factors...
November 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29180957/age-related-brain-activation-changes-during-rule-repetition-in-word-matching
#20
Ikram Methqal, Basile Pinsard, Mahnoush Amiri, Maximiliano A Wilson, Oury Monchi, Jean-Sebastien Provost, Yves Joanette
Objective: The purpose of this study was to explore the age-related brain activation changes during a word-matching semantic-category-based task, which required either repeating or changing a semantic rule to be applied. In order to do so, a word-semantic rule-based task was adapted from the Wisconsin Sorting Card Test, involving the repeated feedback-driven selection of given pairs of words based on semantic category-based criteria. Method: Forty healthy adults (20 younger and 20 older) performed a word-matching task while undergoing a fMRI scan in which they were required to pair a target word with another word from a group of three words...
2017: Frontiers in Human Neuroscience
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