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Wesley T O'Neal, Kristine E Lee, Elsayed Z Soliman, Ronald Klein, Barbara E K Klein
PURPOSE: To determine the incidence and determinants of developing abnormalities on the 12-lead electrocardiogram (ECG) in persons with type 1 diabetes. METHODS: We evaluated the distribution of ECG abnormalities and risk factors for developing new abnormalities in 266 (mean age = 44 years ± 9.0; 50 % female) people with type 1 diabetes from the Wisconsin Epidemiologic Study of Diabetic Retinopathy. This analysis included participants with complete ECG data from study visit 5 (2000-2001) and follow-up ECGs from study visit 7 (2012-2014)...
October 20, 2016: Journal of Endocrinological Investigation
O Laporta-Hoyos, J Ballester-Plané, P Póo, A Macaya, M Meléndez-Plumed, E Vázquez, I Delgado, L Zubiaurre-Elorza, V L Botellero, A Narberhaus, E Toro-Tamargo, D Segarra, R Pueyo
PURPOSE: Quality of life (QOL) is a key outcome for people with cerebral palsy (CP), and executive functioning is an important predictor of QOL in other health-related conditions. Little is known about this association in CP or about its neural substrate. We aim to analyze the influence of executive functioning (including cognitive flexibility) as well as that of other psychological, motor, communication and socioeconomic variables on QOL and to identify neuroanatomical areas related to QOL in adolescents and adults with CP...
October 20, 2016: Quality of Life Research
Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci, Fusun Yildiz
BACKGROUND: The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation Syndrome (OHS) patients. METHODS: Ten healthy normal and obese controls, 10 OHS and 10 OSAS patients were included in the study. Short form-36, Beck Depression Scale and State-Trade Anxiety Inventory (STAI 1-2) were performed. Wisconsin Card Sorting Test (WCST), Montreal Cognitive Assessment Scale (MOCA), Enhanced Cued Recall (ECR) and Mini Mental Test (MMT) were used for neurocognitive evaluation...
2016: Multidisciplinary Respiratory Medicine
Kate E Smith, Martin M Shafer, Debora Weiss, Henry A Anderson, Patrick R Gorski
Exposure to the neurotoxic element lead (Pb) continues to be a major human health concern, particularly for children in US urban settings, and the need for robust tools for assessment of exposure sources has never been greater. The latest generation of multicollector inductively coupled plasma mass spectrometry (MC-ICPMS) instrumentation offers the capability of using Pb isotopic signatures as a tool for environmental source tracking in public health. We present a case where MC-ICPMS was applied to isotopically resolve Pb sources in human clinical samples...
October 19, 2016: Biological Trace Element Research
Anna G Mirer, Terry Young, Mari Palta, Ruth M Benca, Amanda Rasmuson, Paul E Peppard
OBJECTIVE: Menopause is widely believed to be an established cause of sleep disorders, but evidence for this theory is inconclusive. Attributing any sleep problem to normal processes of menopause may lead to underdiagnosis of treatable sleep disorders in midlife women. This study uses detailed longitudinal data on sleep and menopausal health from participants in the Sleep in Midlife Women Study to investigate whether risk and severity of sleep-disordered breathing increase with progression through menopause, accounting for changes in age and body habitus...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
Maria Cancian, Yiyoon Chung, Daniel R Meyer
We consider the intersection between two striking U.S. trends: dramatic increases in the imprisonment of fathers and increases in the proportion of mothers who have children with more than one partner (multiple-partner fertility, or MPF). Using matched longitudinal administrative data that provide unusually comprehensive and accurate information about the occurrence and timing of imprisonment, fertility, and MPF for the population of the state of Wisconsin, we consider the relationship between paternal imprisonment and MPF among unwed mothers...
October 18, 2016: Demography
Eric M Vogelsang
In an aging world, there is increased need to identify places and characteristics of places that promote health among older adults. This study examines whether there are rural-urban differences in older adult social participation and its relationship with health. Using the 2003 and 2011 waves of the Wisconsin Longitudinal Study (n=3006), I find that older adults living in rural counties are less socially active than their counterparts in more-urban counties. I also find that relationships between social participation and health vary by the type of activity and rural-urban context...
October 15, 2016: Health & Place
John T Crawford, Emily H Stanley
Streams and rivers are active processors of carbon, leading to significant emissions of CO2 and possibly CH4 to the atmosphere. Patterns and controls of CH4 in fluvial ecosystems remain relatively poorly understood. Furthermore, little is known regarding how major human impacts to fluvial ecosystems may be transforming their role as CH4 producers and emitters. Here, we examine the consequences of two distinct ecosystem changes as a result of human land use: increased nutrient loading (primarily as nitrate), and increased sediment loading and deposition of fine particles in the benthic zone...
July 2016: Ecological Applications: a Publication of the Ecological Society of America
Erin L Abner, Pamela B Teaster, Marta S Mendiondo, Holly Ramsey-Klawsnik, Jennifer L Marcum, Tim N Crawford, Tenzin Wangmo
The purpose of this study was to identify characteristics of investigations of sexual abuse concerning vulnerable adults residing in facility settings that were associated with case substantiation. Data on 410 reports of sexual abuse were collected prospectively from Adult Protective Services (APS) and state licensure agency staff in New Hampshire, Oregon, Tennessee, Texas, and Wisconsin over a six-month period. Specifically, we examined differences between reports that were substantiated and those that were not by comparing characteristics of alleged victims, alleged perpetrators, and aspects of investigation using logistic regression...
October 17, 2016: Journal of Interpersonal Violence
Lynn R Gilbertson, Liza E Thies, Donna J H Vosburgh
One of the leading causes of noise induced hearing loss is occupational noise exposure; however, little attention has been given to the exposure among amusement ride operators. According to the International Association of Amusement Parks and Attractions, 600,000 ride operators are employed in the United States. The first objective of this descriptive study was to evaluate if ride operators were exposed to noise levels over 85 dB. The second objective was to classify the ride features that led to the highest noise levels...
October 18, 2016: Journal of Occupational and Environmental Hygiene
Viola Grabs, Anna Kersten, Bernhard Haller, Siegmund Braun, David C Nieman, Martin Halle, Johannes Scherr
INTRODUCTION: Vigorous and prolonged exercise such as marathon running increases inflammatory markers and the risk of upper respiratory illness (URI) in athletes. Nutritional supplements are being tested as countermeasures of exercise-induced inflammation and immune dysfunction. METHODS: In this prospective randomized, double-blind, placebo-controlled Phase I trial, healthy male runners (N = 138, age 42 ± 11 y) were supplemented with rutoside (600-1200 mg/day) and hydrolytic enzymes (540-1,080 mg/day bromelain, 288-576 mg/day trypsin) (WOB) or placebo (PL) for one week before and two weeks after the Munich Marathon 2013...
October 6, 2016: Medicine and Science in Sports and Exercise
Veronica Bertini, Alessandro Orsini, Roberta Mazza, Vineela Mandava, Giuseppe Saggese, Alessia Azzara', Alice Bonuccelli, Angelo Valetto
We report on a patient with a 6.5 Mb interstitial de novo deletion in 3q24q25.2, characterized by array CGH. The patient is a 4-year and 2-month-old girl, who presented to us with mild developmental delay, absence of language, facial dysmorphism, hirsutism, strabismus, and Dandy-Walker Malformation. The main clinical signs typical of WS (Wisconsin syndrome) are evident in the patient. The molecular mapping of WS in 3q23q25 allowed geneticists to define the syndrome more accurately. Comparing the present patient's phenotype with that of cases with a molecular characterization so far reported, it was possible to narrow the critical region for WS to an interval of 750 Kb, where two genes (MBNL1 and TMEM14E) are harbored...
October 18, 2016: American Journal of Medical Genetics. Part A
Julia L Feldman, Antonio L Freitas
The study of the conflict-adaptation effect, in which encountering information-processing conflict attenuates the disruptive influence of information-processing conflicts encountered subsequently, is a burgeoning area of research. The present study investigated associations among performance measures on a Stroop-trajectory task (measuring Stroop interference and conflict adaptation), on a Wisconsin Card Sorting Task (WCST; measuring cognitive flexibility), and on self-reported measures of self-regulation (including impulsivity and tenacity)...
July 2016: Experimental Psychology
Naomi A Hartley, Ellen Breen, Susan L Thibeault
Purpose: The purpose of this study was to document typical vocal health characteristics (including voice-related activities, behaviors, and symptomatology) of young adults attending college and to determine lifetime and point prevalence rates of voice disorders. Method: Undergraduates at University of Wisconsin-Madison completed an anonymous online survey detailing vocal use, symptomatology, impact, sociodemographics, and voice-related quality of life. Univariate analyses and multivariate regression models isolated risk factors for lifetime and point prevalence rates of a voice disorder...
October 17, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
Marcela Suárez-Esquivel, Nazareth Ruiz-Villalobos, Amanda Castillo-Zeledón, César Jiménez-Rojas, R Martin Roop Ii, Diego J Comerci, Elías Barquero-Calvo, Carlos Chacón-Díaz, Clayton C Caswell, Kate S Baker, Esteban Chaves-Olarte, Nicholas R Thomson, Edgardo Moreno, Jean J Letesson, Xavier De Bolle, Caterina Guzmán-Verri
Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research in brucellosis is carried out by using reference strains as canonical models to understand the mechanisms underlying host pathogen interactions. We performed whole genome sequencing analysis of the reference strain B. abortus 2308 routinely used in our laboratory, including manual curated annotation accessible as an editable version through a link at https://en...
2016: Frontiers in Microbiology
Conxa Perpiñá, Mara Segura, Sergio Sánchez-Reales
OBJECTIVE: The aim of the present study was to compare decision-making and cognitive flexibility in patients with disordered eating and weight, ranging from anorexia nervosa to obesity, and a healthy group. METHOD: Participants were 113 patients (86 with eating disorders and 27 with obesity), and a group of 39 healthy subjects; all completed the Iowa gambling task, the Wisconsin Card Sorting Test and several clinical self-report measures. RESULTS: Eating disordered and obese patients showed impaired performance on the decision-making task, and the obese group showed the worst performance on the set-shifting task...
October 15, 2016: Eating and Weight Disorders: EWD
F C Ferreira, R S Gennari, G E Dahl, A De Vries
Heat stress during the dry period reduces milk yield in the subsequent lactation of dairy cows. Our objectives were to quantify the economic losses due to heat stress if dry cows are not cooled and to evaluate the economic feasibility of dry cow cooling. We used weather data from the National Oceanic and Atmospheric Administration to calculate the number of heat stress days for each of the 50 US states. A heat stress day was declared when the daily average temperature-humidity index was ≥68. The number of dairy cows in each state in 2015 was obtained from the USDA-National Agricultural Statistics Service...
October 13, 2016: Journal of Dairy Science
I Lobb, J Jiang, D Lian, W Liu, A Haig, M N Saha, R Torregrossa, M E Wood, M Whiteman, A Sener
Ischemia-reperfusion injury (IRI) is unavoidably caused by loss and subsequent restoration of blood flow during organ procurement and prolonged IRI results in increased rates of delayed graft function and early graft loss. The endogenously produced gasotransmitter, hydrogen sulfide (H2 S), is a novel molecule that mitigates hypoxic tissue injury. The current study investigates the protective mitochondrial effects of H2 S during in vivo cold storage and subsequent renal transplantation (RTx) and in vitro cold hypoxic renal injury...
October 15, 2016: American Journal of Transplantation
L Meng, N Matsuno, K Watanabe, M Furukori, H Obara, H Bochimoto, T Watanabe, H Fukukawa
BACKGROUND: The shortage of organ donors is a universal problem. Use of grafts from donors after cardiac death would greatly contribute to the expansion of the donor organ pool. The two major methods of preservation are cold storage and machine perfusion (MP) preservation, and each has its own advantages. Several studies have reported the relative merits of MP for the preservation for grafts from donors after cardiac death. In this study, we used scanning electron microscopy (SEM) to assess the damage to the liver between hypothermic and rewarming preservation conditions...
September 2016: Transplantation Proceedings
Yu-Shu Huang, Christian Guilleminault, Fang-Ming Hwang, Chuan Cheng, Cheng-Hui Lin, Hsueh-Yu Li, Li-Ang Lee
Pediatric obstructive sleep apnea (OSA) is associated with chronic systemic inflammation and with cognitive impairments. This study aimed to investigate the status of proinflammatory cytokines, particularly interleukin 17 (IL-17) and interleukin 23 (IL-23) and cognition in pediatric OSA.Controls and OSA children participated in the study. Exclusion criteria were adenotonsillectomy, heart, neurological and severe psychiatric diseases, craniofacial syndromes, and obesity. Polysomnogram was followed by serum testing for inflammatory markers and neurocognitive tests such as continuous performance task (CPT) and Wisconsin card sorting test, questionnaires, analyses of plasma high-sensitivity C-reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), IL-17, and IL-23...
October 2016: Medicine (Baltimore)
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