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https://www.readbyqxmd.com/read/28642988/development-of-pulmonary-hypertension-during-treatment-with-diazoxide-a-case-series-and-literature-review
#1
Matthew R Timlin, Alexander B Black, Heather M Delaney, Renée I Matos, Candace S Percival
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy. The mainstay of medical management for CHI is diazoxide. Diazoxide inhibits insulin release from the pancreas, but also causes smooth muscle relaxation and fluid retention so it is typically given with chlorothiazide. In July 2015, the FDA issued a drug safety communication warning that pulmonary hypertension (PH) had been reported in 11 infants being treated with diazoxide and that the PH resolved with withdrawal of diazoxide...
June 22, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28637779/racial-differences-in-arterial-stiffness-are-mainly-determined-by-blood-pressure-levels-results-from-the-elsa-brasil-study
#2
Marcelo P Baldo, Roberto S Cunha, Antônio L P Ribeiro, Paulo A Lotufo, Dora Chor, Sandhi M Barreto, Isabela M Bensenor, Alexandre C Pereira, José Geraldo Mill
BACKGROUND: Black people have a higher risk of developing hypertension and presenting higher vascular stiffening. Our aim was to investigate whether the association between race and aortic stiffness could be explained by differences in the primary risk factors. METHODS AND RESULTS: We analyzed data from 11 472 adults (mean age, 51.9±8.9; 53.8% female) self-reported as white (n=6173), brown (n=3364), or black (n=1935). Their carotid-to-femoral pulse wave velocity (cf-PWV) as well as clinical and anthropometric parameters were measured...
June 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28634217/incident-cardiovascular-disease-among-adults-with-blood-pressure-140-90-mm-hg
#3
Gabriel S Tajeu, John N Booth, Lisandro D Colantonio, Rebecca F Gottesman, George Howard, Daniel T Lackland, Emily O'Brien, Suzanne Oparil, Joseph E Ravenell, Monika M Safford, Samantha R Seals, Daichi Shimbo, Steven Shea, Tanya M Spruill, Rikki M Tanner, Paul Muntner
Background -Data from before the 2000s indicate the majority of incident cardiovascular disease (CVD) events occur among US adults with systolic and diastolic blood pressure (SBP/DBP)≥140/90 mmHg. Over the past several decades, BP declined and hypertension control has improved. Methods -We estimated the percentage of incident CVD events that occur at SBP/DBP<140/90 mmHg in a pooled analysis of three contemporary US cohorts: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, the Multi-Ethnic Study of Atherosclerosis (MESA), and the Jackson Heart Study (JHS) (n=31,856; REGARDS=21,208; MESA=6,779; JHS=3,869)...
June 20, 2017: Circulation
https://www.readbyqxmd.com/read/28633432/factors-associated-with-home-blood-pressure-monitoring-among-us-adults-national-health-and-nutrition-examination-survey-2011-2014
#4
Yechiam Ostchega, Guangyu Zhang, Brian K Kit, Tatiana Nwankwo
BACKGROUND: Home blood pressure monitoring (HBPM) has a substantial role in hypertension management and control. METHODS: Cross-sectional data for noninstitutionalized US adults 18 years and older (10,958) from the National Health and Nutrition Examination Survey (NHANES), years 2011-2014, were used to examine factors related to HBPM. RESULTS: In 2011-2014, estimated 9.5% of US adults engaged in weekly HBPM, 7.2% engaged in monthly HBPM, 8...
June 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28629624/the-protective-role-of-oestradiol-against-silent-myocardial-ischemia-and-hypertension-risk-in-south-african-men-the-sabpa-study
#5
Nicolaas T Malan, Roland von Känel, Hendrik S Steyn, Ruan Kruger, Leoné Malan
BACKGROUND: Oestradiol has a protective effect on coronary artery health in women but the effect it has on men, is controversial. A translational approach was followed to assess whether sex hormone levels are associated with silent myocardial ischemia (SMI) and hypertension risk over a 3year period. METHODS: Participants included 89 Black and 91 White men (aged 21-63years) participating in both phases of the Sympathetic activity and Ambulatory Blood Pressure in Africans prospective study...
June 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28611152/hepatic-vein-pressure-predicts-gfr-in-cirrhotic-patients-with-hemodynamic-kidney-dysfunction
#6
Neel Desai, Joel Neugarten, Mary Dominguez, Ladan Golestaneh
The role of "nephrocongestion" in hemodynamic renal disease is understudied. Intra-abdominal hypertension accompanies liver disease and renal disease. Our hypothesis states that in those patients with liver disease, hepatic vein pressure measured during a transjugular intrahepatic portosystemic shunt (TIPS) procedure reflects intra-abdominal pressure and predicts estimated glomerular filtration rate (eGFR). We gathered data from our clinical database and chart review on a cohort of cirrhotic patients who received TIPS at Montefiore as part of their clinical care between 2004 and 2014...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28606731/cognitive-function-and-kidney-disease-baseline-data-from-the%C3%A2-systolic-blood-pressure-intervention-trial-sprint
#7
Daniel E Weiner, Sarah A Gaussoin, John Nord, Alexander P Auchus, Gordon J Chelune, Michel Chonchol, Laura Coker, William E Haley, Anthony A Killeen, Paul L Kimmel, Alan J Lerner, Suzanne Oparil, Mohammad G Saklayen, Yelena M Slinin, Clinton B Wright, Jeff D Williamson, Manjula Kurella Tamura
BACKGROUND: Chronic kidney disease is common and is associated with cardiovascular disease, cerebrovascular disease, and cognitive function, although the nature of this relationship remains uncertain. STUDY DESIGN: Cross-sectional cohort using baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT). SETTING & PARTICIPANTS: Participants in SPRINT, a randomized clinical trial of blood pressure targets in older community-dwelling adults with cardiovascular disease, chronic kidney disease, or high cardiovascular disease risk and without diabetes or known stroke, who underwent detailed neurocognitive testing in the cognition substudy, SPRINT-Memory and Cognition in Decreased Hypertension (SPRINT-MIND)...
June 9, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28601194/relation-between-obesity-and-survival-in-patients-hospitalized-for-pulmonary-arterial-hypertension-from-a-nationwide-inpatient-sample-database-2003-to-2011
#8
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Carl J Lavie
There have been numerous studies reporting lower mortality rates in obese patients with various cardiovascular disorders than in nonobese patients, a phenomenon known as the "obesity paradox." Limited data exist regarding the effect of obesity on prognosis in patients with pulmonary arterial hypertension (PAH). We used the National Inpatient Sample database for years 2003 to 2011 to identify all patient hospitalizations aged ≥18 years with a primary diagnosis of PAH. Patients with a diagnosis of obesity were identified using Elixhauser co-morbidity measure provided in Nationwide Inpatient Sample database, based on International Classification of Diseases, Ninth Revision, Clinical Modification, codes and the diagnosis-related groups...
May 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28591347/factors-associated-with-self-reported-diabetes-according-to-the-2013-national-health-survey
#9
Deborah Carvalho Malta, Regina Tomie Ivata Bernal, Betine Pinto Moehlecke Iser, Célia Landmann Szwarcwald, Bruce Bartholow Duncan, Maria Inês Schmidt
OBJECTIVES: To analyze the factors associated with self-reported diabetes among adult participants of the National Health Survey (PNS). METHODS: Cross-sectional study using data of the PNS carried out in 2013, from interviews with adults (≥ 18 years) of 64,348 Brazilian households. The prevalence of self-reported diabetes, assessed by the question "Has a doctor ever told you that you have diabetes?," was related to sociodemographic characteristics, lifestyle, self-reported chronic disease, and self-evaluation of the health condition...
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28583968/racial-and-ethnic-disparities-persist-at-veterans-health-administration-patient-centered-medical-homes
#10
Donna L Washington, W Neil Steers, Alexis K Huynh, Susan M Frayne, Uchenna S Uchendu, Deborah Riopelle, Elizabeth M Yano, Fay S Saechao, Katherine J Hoggatt
Patient-centered medical homes are widely promoted as a primary care delivery model that achieves better patient outcomes. It is unknown if their benefits extend equally to all racial/ethnic groups. In 2010 the Veterans Health Administration, part of the Department of Veterans Affairs (VA), began implementing patient-centered medical homes nationwide. In 2009 significant disparities in hypertension or diabetes control were present for most racial/ethnic groups, compared with whites. In 2014 hypertension disparities were similar for blacks, had become smaller but remained significant for Hispanics, and were no longer significant for multiracial veterans, whereas disparities had become significant for American Indians/Alaska Natives and Native Hawaiians/other Pacific Islanders...
June 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28578174/maternal-marijuana-use-adverse-pregnancy-outcomes-and-neonatal-morbidity
#11
Torri D Metz, Amanda A Allshouse, Carol J Rowland Hogue, Robert L Goldenberg, Donald J Dudley, Michael W Varner, Deborah L Conway, George R Saade, Robert M Silver
BACKGROUND: The Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network previously demonstrated an association between stillbirth and maternal marijuana use as defined by the presence of tetrahydrocannabinol in the umbilical cord homogenate. However, the relationship between marijuana use and perinatal complications in live births is uncertain. OBJECTIVE: Our aim was to examine if maternal marijuana use is associated with increased odds of adverse pregnancy outcomes and neonatal morbidity among live-born controls in the Stillbirth Collaborative Research Network cohort...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28578169/maternal-race-and-intergenerational-preterm-birth-recurrence
#12
Marcela C Smid, Jong Hyung Lee, Jacqueline H Grant, Gandarvaka Miles, Gregory J Stoddard, Derek A Chapman, Tracy A Manuck
BACKGROUND: Preterm birth is a complex disorder with a heritable genetic component. Studies of primarily white women born preterm show that they have an increased risk of subsequently delivering preterm. This risk of intergenerational preterm birth is poorly defined among black women. OBJECTIVE: Our objective was to evaluate and compare intergenerational preterm birth risk among non-Hispanic black and white mothers. STUDY DESIGN: This was a population-based retrospective cohort study, using the Virginia Intergenerational Linked Birth File...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28572159/apol1-risk-variants-and-cardiovascular-disease-results-from-the-aask-african-american-study-of-kidney-disease-and-hypertension
#13
Teresa K Chen, Lawrence J Appel, Morgan E Grams, Adrienne Tin, Michael J Choi, Michael S Lipkowitz, Cheryl A Winkler, Michelle M Estrella
OBJECTIVE: Among black, the apolipoprotein L1 (APOL1) risk variants have been associated with various types of kidney disease and chronic kidney disease progression. We aimed to determine whether these same risk variants also confer an increased risk for cardiovascular disease. APPROACH AND RESULTS: In a cohort of blacks with hypertension-attributed chronic kidney disease followed for up to 12 years, we used Cox proportional hazards models to estimate the relative hazard of a composite cardiovascular disease outcome (cardiovascular death or hospitalization for myocardial infarction, cardiac revascularization procedure, heart failure, or stroke) for the APOL1 high- (2 risk variants) versus low-risk (0-1 risk variant) genotypes...
June 1, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28570148/an-official-american-thoracic-society-workshop-report-obesity-and-metabolism-an-emerging-frontier-in-lung-health-and-disease
#14
Benjamin T Suratt, Niki D J Ubags, Deepa Rastogi, Kelan G Tantisira, Benjamin J Marsland, Irina Petrache, Janice B Allen, Jason H T Bates, Fernando Holguin, Meredith C McCormack, Evangelos D Michelakis, Stephen M Black, Manu Jain, Ana L Mora, Viswanathan Natarajan, Yury I Miller, Michael B Fessler, Konstantin G Birukov, Ross S Summer, Stephanie A Shore, Anne E Dixon
The world is in the midst of an unprecedented epidemic of obesity. This epidemic has changed the presentation and etiology of common diseases. For example, steatohepatitis, directly attributable to obesity, is now the most common cause of cirrhosis in the United States. Type 2 diabetes is increasingly being diagnosed in children. Pulmonary researchers and clinicians are just beginning to appreciate the impact of obesity and altered metabolism on common pulmonary diseases. Obesity has recently been identified as a major risk factor for the development of asthma and for acute respiratory distress syndrome...
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28558917/urinary-f2-isoprostanes-and-the-risk-of-hypertension
#15
Charles David Melton, Ruiyan Luo, Brett J Wong, Ivan Spasojevic, Lynne E Wagenknecht, Ralph B D'Agostino, Dora Il'yasova
PURPOSE: There is strong biological plausibility for a causal role of reactive oxygen species in vascular pathology but no direct epidemiological evidence linking elevated reactive oxygen species levels to hypertension development. We examined cross-sectional and prospective associations between oxidative status (urinary F2-isoprostanes) and hypertension in the Insulin Resistance Atherosclerosis Study cohort (n = 831). METHODS: The cohort included non-Hispanic white, Hispanic, and non-Hispanic black individuals, with 252 (30%) having prevalent hypertension and 579 participants normotensive at baseline, 122 (21%) of whom developed hypertension during the 5-year follow-up...
May 17, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28554700/-left-ventricular-hypertrophy-in-black-african-subjects-with-artery-hypertension-results-of-a-cross-sectional-survey-conducted-in-semi-rural-area-in-senegal
#16
A Mbaye, B Dodo, A A Ngaïde, N F Sy, K Babaka, J S Mingou, M Faye, K Niang, S A Sarr, M Dioum, M Bodian, M B Ndiaye, A D Kane, M Ndour-Mbaye, M Diao, B Diack, M Kane, D Diagne-Sow, I Thiaw, A Kane
OBJECTIVES: To assess the prevalence of left ventricular hypertrophy according to electrocardiographic and echocardiographic criteria among hypertensive patients living in semi-rural Senegalese area. PATIENTS AND METHODS: According to the World Health Organization STEPSwise approach, we conducted, in November 2012, a cross-sectional and exhaustive study in the population aged at least 35 years old and living for at least six months in the semi-rural area of Guéoul...
May 26, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28554178/vitamin-d-and-albuminuria-in-youth-with-and-without-type-1-diabetes
#17
Debika Nandi-Munshi, Maryam Afkarian, Kathryn B Whitlock, Jamie L Crandell, Ronny A Bell, Ralph D'Agostino, Sharon Saydah, Amy K Mottl, Dana Dabelea, Mary Helen Black, Elizabeth J Mayer-Davis, Catherine Pihoker
BACKGROUND/AIMS: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. METHODS: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001-2006 (NHANES), who were 6-19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes...
May 29, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28551306/metformin-prescribing-in-low-income-and-insured-patients-with-prediabetes
#18
Jun Wu, Eileen Ward, Tiffaney Threatt, Zhiqiang K Lu
OBJECTIVES: To describe prescribing patterns of metformin in low-income and Medicaid-insured patients with prediabetes and to identify common demographic characteristics and comorbid conditions of low-income and Medicaid-insured patients receiving metformin for treatment of prediabetes. DESIGN: Retrospective observational study. SETTING AND PARTICIPANTS: Patients (18-60 years old) who were enrolled in South Carolina Medicaid and diagnosed with prediabetes between January 2009 and December 2013...
May 24, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28549758/prevalence-of-abdominal-obesity-and-its-association-with-cardio-metabolic-risk-factors-among-older-adults-in-ecuador
#19
Carlos H Orces, Martha Montalvan, Daniel Tettamanti
AIMS: To describe the prevalence of abdominal obesity and its association with cardio metabolic risk factors among older adults in Ecuador. MATERIALS AND METHODS: The present study used data from the National Survey of Health, Wellbeing, and Aging survey to examine the prevalence of abdominal obesity according to certain demographic, behavioral, and health characteristics of the participants. Logistic regression models adjusted for potential confounders were used to evaluate the association of abdominal obesity with cardio metabolic risk factors...
May 15, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28545715/apol1-genetic-variants-are-not-associated-with-longitudinal-blood-pressure-in-young-black-adults
#20
Teresa K Chen, Michelle M Estrella, Eric Vittinghoff, Feng Lin, Orlando M Gutierrez, Holly Kramer, Cora E Lewis, Jeffrey B Kopp, Norrina B Allen, Cheryl A Winkler, Kirsten B Bibbins-Domingo, Carmen A Peralta
Whether APOL1 polymorphisms contribute to the excess risk of hypertension among blacks is unknown. To assess this we evaluated whether self-reported race and, in blacks, APOL1 risk variants (high-risk [2 risk alleles] versus low-risk [0-1 risk allele]) were associated with longitudinal blood pressure. Blood pressure trajectories were determined using linear mixed-effects (slope) and latent class models (5 distinct groups) during 25 years of follow-up in the Coronary Artery Risk Development in Young Adults Study...
May 23, 2017: Kidney International
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