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Hypertension in black

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https://www.readbyqxmd.com/read/28346156/association-of-sleep-characteristics-with-cardiovascular-and-metabolic-risk-factors-in-a-population-sample-the-chicago-area-sleep-study
#1
Samantha E Montag, Kristen L Knutson, Phyllis C Zee, Jeffrey J Goldberger, Jason Ng, Kwang-Youn A Kim, Mercedes R Carnethon
OBJECTIVES: To investigate the association of sleep characteristics with prevalent hypertension, diabetes, and obesity in a multiethnic cohort. DESIGN: This study used a population-based cross-sectional study design. SETTING: Participants were recruited between 2009 and 2011 from Chicago, Illinois, and the surrounding suburbs. PARTICIPANTS: Participants were 492 adults aged 35 to 64years who self-reported as white, black, Hispanic, or Asian and who had a low likelihood of sleep apnea based on the apnea screening questionnaires and 1 night of apnea screening using an in-home device (apnea hypopnea index <15 or oxygen desaturation index <10)...
April 2017: Sleep Health
https://www.readbyqxmd.com/read/28341776/an-nppb-promoter-polymorphism-associated-with-elevated-n-terminal-pro-b-type-natriuretic-peptide-and-lower-blood-pressure-hypertension-and-mortality
#2
Sara B Seidelmann, Orly Vardeny, Brian Claggett, Bing Yu, Amil M Shah, Christie M Ballantyne, Elizabeth Selvin, Calum A MacRae, Eric Boerwinkle, Scott D Solomon
BACKGROUND: Elevated B-type natriuretic peptide (BNP) levels are associated with heart failure and increased mortality in the general population. We investigated rs198389, a functional variant in the promoter region of the BNP gene (NPPB), in patients from the Atherosclerosis Risk in Communities Study to investigate associations with N-terminal pro-BNP (NT-proBNP) levels and outcomes. METHODS AND RESULTS: A total of 11 361 black and white patients with rs198389 genotyping attended visit 1 (aged 45-64 years; 1987-1989), with follow-up visits occurring every 3 years (visit 2-visit 4, 1990-1999), followed by visit 5 (2011-2013)...
March 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28333708/cost-effectiveness-of-antihypertensive-medication-exploring-race-and-sex-differences-using-data-from-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#3
Gabriel S Tajeu, Stephen Mennemeyer, Nir Menachemi, Robert Weech-Maldonado, Meredith Kilgore
BACKGROUND: Antihypertensive medication decreases risk of cardiovascular disease (CVD) events in adults with hypertension. Although black adults have higher prevalence of hypertension and worse CVD outcomes compared with whites, limited attention has been given to the cost-effectiveness of antihypertensive medication for blacks. OBJECTIVE: To compare the cost-effectiveness of antihypertensive medication treatment versus no-treatment in white and black adults. RESEARCH DESIGN: We constructed a State Transition Model to assess the costs and quality-adjusted life-years (QALYs) associated with either antihypertensive medication treatment or no-treatment using data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study and published literature...
March 22, 2017: Medical Care
https://www.readbyqxmd.com/read/28332510/recent-advances-in-understanding-hypertension-development-in-sub-saharan-africa
#4
REVIEW
A E Schutte, S Botha, C M T Fourie, L F Gafane-Matemane, R Kruger, L Lammertyn, L Malan, C M C Mels, R Schutte, W Smith, J M van Rooyen, L J Ware, H W Huisman
Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provides an outline of recent advances in the pathophysiological understanding of blood pressure elevation and the consequences thereof in black populations in Africa. This is set against the backdrop of populations undergoing demanding and rapid demographic transition, where infection with the human immunodeficiency virus predominates, and where under and over-nutrition coexist...
March 23, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28329429/racial-disparity-in-life-expectancies-and-life-years-lost-associated-with-multiple-obesity-related-chronic-conditions
#5
Su-Hsin Chang, Yao-Chi Yu, Nils P Carlsson, Xiaoyan Liu, Graham A Colditz
OBJECTIVE: This study investigated racial disparity in life expectancies (LEs) and life years lost (LYL) associated with multiple obesity-related chronic conditions (OCCs). METHODS: Data from the Medical Expenditure Panel Survey, 2008-2012, were used. Four OCCs were studied: diabetes, hypertension, coronary heart disease (CHD), and stroke. LE for each subpopulation was simulated by Markov modelling. LYL associated with a disease for a subpopulation was computed by taking the difference between LEs for members of that subpopulation without disease and LEs for members of that subpopulation who had that disease...
March 22, 2017: Obesity
https://www.readbyqxmd.com/read/28329254/periodic-limb-movements-and-white-matter-hyperintensities-in-first-ever-minor-stroke-or-high-risk-tia
#6
Mark I Boulos, Brian J Murray, Ryan T Muir, Fuqiang Gao, Gregory M Szilagyi, Menal Huroy, Alexander Kiss, Arthur S Walters, Sandra E Black, Andrew S Lim, Richard H Swartz
Study Objectives: Emerging evidence suggests that periodic limb movements (PLMs) may contribute to the development of cerebrovascular disease. White matter hyperintensities (WMHs), a widely accepted biomarker for cerebral small vessel disease, are associated with incident stroke and death. We evaluated the association between increased PLM indices and WMH burden in patients presenting with stroke or transient ischemic attack (TIA), while controlling for vascular risk factors and stroke severity...
December 29, 2016: Sleep
https://www.readbyqxmd.com/read/28320850/hypertension-in-blacks-unanswered-questions-and-future-directions-for-the-jhs-jackson-heart-study
#7
REVIEW
Paul Muntner, Marwah Abdalla, Adolfo Correa, Michael Griswold, John E Hall, Daniel W Jones, George A Mensah, Mario Sims, Daichi Shimbo, Tanya M Spruill, Katherine L Tucker, Lawrence J Appel
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28319485/recent-trends-in-the-prevalence-of-chronic-kidney-disease-not-the-same-old-song
#8
Raymond K Hsu, Neil R Powe
PURPOSE OF REVIEW: We aim to review recent updates on the epidemiology of chronic kidney disease (CKD). RECENT FINDINGS: Recent analyses from the National Health and Nutritional Examination survey describe the temporal trend in CKD prevalence in US adults. The overall prevalence of estimated glomerular filtration rate less than 60 ml/min/1.73 m increased from 4.8% in 1988-1994 to 6.9% in 2003-2004, but has since stabilized at 6.4-6.9% up to 2011-2012. Prevalence of CKD stages 1-4 has also stabilized at ∼14% of adults since 2003-2004...
March 17, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28306228/diagnosis-natural-history-and-management-in-vascular-ehlers-danlos-syndrome
#9
Peter H Byers, John Belmont, James Black, Julie De Backer, Michael Frank, Xavier Jeunemaitre, Diana Johnson, Melanie Pepin, Leema Robert, Lynn Sanders, Nigel Wheeldon
Vascular Ehlers Danlos syndrome (vEDS) is an uncommon genetic disorders characterized by arterial aneurysm, dissection and rupture, bowel rupture, and rupture of the gravid uterus. The frequency is estimated as 1/50,000-1/200,000 and results from pathogenic variants in COL3A1, which encodes the chains of type III procollagen, a major protein in vessel walls and hollow organs. Initial diagnosis depends on the recognitions of clinical features, including family history. Management is complex and requires multiple specialists who can respond to and manage the major complications...
March 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28296146/epidemiology-of-uterine-fibroids-a-systematic-review
#10
REVIEW
Elizabeth A Stewart, Charlotte Cookson, Ruth A Gandolfo, Renate Schulze-Rath
BACKGROUND: Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility. OBJECTIVES: To examine UF epidemiology and to evaluate the relative strengths of putative risk factors. SEARCH STRATEGY: MEDLINE and Embase were searched for studies published in English between January 1995 and April 2015. SELECTION CRITERIA: Publications reporting relevant data from registries and other observational studies with over 1000 patients and single-centre studies with over 100 patients were selected...
March 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28287293/-classical-antihypertensive-drugs-diuretics
#11
Viktor László Nagy
The diuretics are essential medicaments of antihypertensive therapy. They reduce blood pressure and cardiovascular events optimally. With increasing doses of thiazides and thiazide analogs do not come further powerful effect of reducing blood pressure or cardiovascular mortality and morbidity, but clearly elevate the side effects. Because of it, the minimum effective dose level and the fixed-dose combination therapy should be preferred. The use these drugs leads to especially positive outcome in elder patients, isolated systolic hypertension, heart failure, after stroke and in black population...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28267855/association-between-dietary-factors-and-mortality-from-heart-disease-stroke-and-type-2-diabetes-in-the-united-states
#12
Renata Micha, Jose L Peñalvo, Frederick Cudhea, Fumiaki Imamura, Colin D Rehm, Dariush Mozaffarian
Importance: In the United States, national associations of individual dietary factors with specific cardiometabolic diseases are not well established. Objective: To estimate associations of intake of 10 specific dietary factors with mortality due to heart disease, stroke, and type 2 diabetes (cardiometabolic mortality) among US adults. Design, Setting, and Participants: A comparative risk assessment model incorporated data and corresponding uncertainty on population demographics and dietary habits from National Health and Nutrition Examination Surveys (1999-2002: n = 8104; 2009-2012: n = 8516); estimated associations of diet and disease from meta-analyses of prospective studies and clinical trials with validity analyses to assess potential bias; and estimated disease-specific national mortality from the National Center for Health Statistics...
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28267756/a-stillbirth-calculator-development-and-internal-validation-of-a-clinical-prediction-model-to-quantify-stillbirth-risk
#13
Amanda S Trudell, Methodius G Tuuli, Graham A Colditz, George A Macones, Anthony O Odibo
OBJECTIVE: To generate a clinical prediction tool for stillbirth that combines maternal risk factors to provide an evidence based approach for the identification of women who will benefit most from antenatal testing for stillbirth prevention. DESIGN: Retrospective cohort study. SETTING: Midwestern United States quaternary referral center. POPULATION: Singleton pregnancies undergoing second trimester anatomic survey from 1999-2009...
2017: PloS One
https://www.readbyqxmd.com/read/28267687/hypertension-s-3-dilemmas-and-3-solutions-pharmacology-of-the-kidney-in-hypertension
#14
William A Pettinger
The Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy...
March 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28257397/translating-comparative-effectiveness-research-into-practice-effects-of-interventions-on-lifestyle-medication-adherence-and-self-care-for-type-2-diabetes-hypertension-and-obesity-among-black-hispanic-and-asian-residents-of-chicago-and-houston-2010-to-2013
#15
Jamila R Rashid, Brenda A Leath, Benedict I Truman, Donna Durant Atkinson, Lisa C Gary, Nanmathi Manian
CONTEXT: In the United States, racial/ethnic minorities account for disproportionate disease and death from type 2 diabetes, hypertension, and obesity; however, interventions with measured efficacy in comparative effectiveness research are often not adopted or used widely in those communities. OBJECTIVE: To assess implementation and effects of comparative effectiveness research-proven interventions translated for minority communities. DESIGN: Mixed-method assessment with pretest-posttest single-group evaluation design...
March 1, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28255010/heart-failure-incidence-and-mortality-in-the-southern-community-cohort-study
#16
Elvis A Akwo, Edmond K Kabagambe, Thomas J Wang, Frank E Harrell, William J Blot, Michael Mumma, Deepak K Gupta, Loren Lipworth
BACKGROUND: There is a paucity of data on heart failure (HF) incidence among low-income and minority populations. Our objective was to investigate HF incidence and post-HF survival by race and sex among low-income adults in the southeastern United States. METHODS AND RESULTS: Participants were 27 078 white and black men and women enrolled during 2002 to 2009 in the SCCS (Southern Community Cohort Study) who had no history of HF and were receiving Centers for Medicare and Medicaid Services...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28252185/on-target-sorafenib-toxicity-predicts-improved-survival-in-hepatocellular-carcinoma-a-multi-centre-prospective-study
#17
J Howell, D J Pinato, R Ramaswami, D Bettinger, T Arizumi, C Ferrari, C Yen, A Gibbin, M E Burlone, G Guaschino, L Sellers, J Black, M Pirisi, M Kudo, R Thimme, J-W Park, R Sharma
BACKGROUND: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and has high mortality despite treatment. While sorafenib has a survival benefit for patients with advanced HCC, clinical response is highly variable. AIM: To determine whether development of sorafenib toxicity is a prognostic marker of survival in HCC. METHODS: In this prospective multicentre cohort study, patients with advanced-stage HCC receiving sorafenib were recruited from five international specialist centres...
March 2, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28251341/coffee-tea-caffeine-and-risk-of-hypertension-the-singapore-chinese-health-study
#18
Choy-Lye Chei, Julian Kenrick Loh, Avril Soh, Jian-Min Yuan, Woon-Puay Koh
PURPOSE: The relationship between coffee and tea, and risk of hypertension remains controversial in Western populations. We investigated these associations in an Asian population. METHODS: The Singapore Chinese Health Study is a population-based prospective cohort that recruited 63,257 Chinese aged 45-74 years and residing in Singapore from 1993 to 1998. Information on consumption of coffee, tea, and other lifestyle factors was collected at baseline, and self-reported physician-diagnosed hypertension was assessed during two follow-up interviews (1999-2004, 2006-2010)...
March 1, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28245334/association-of-type-1-diabetes-vs-type-2-diabetes-diagnosed-during-childhood-and-adolescence-with-complications-during-teenage-years-and-young-adulthood
#19
Dana Dabelea, Jeanette M Stafford, Elizabeth J Mayer-Davis, Ralph D'Agostino, Lawrence Dolan, Giuseppina Imperatore, Barbara Linder, Jean M Lawrence, Santica M Marcovina, Amy K Mottl, Mary Helen Black, Rodica Pop-Busui, Sharon Saydah, Richard F Hamman, Catherine Pihoker
Importance: The burden and determinants of complications and comorbidities in contemporary youth-onset diabetes are unknown. Objective: To determine the prevalence of and risk factors for complications related to type 1 diabetes vs type 2 diabetes among teenagers and young adults who had been diagnosed with diabetes during childhood and adolescence. Design, Setting, and Participants: Observational study from 2002 to 2015 in 5 US locations, including 2018 participants with type 1 and type 2 diabetes diagnosed at younger than 20 years, with single outcome measures between 2011 and 2015...
February 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28238999/race-genomics-and-chronic-disease-what-patients-with-african-ancestry-have-to-say
#20
Carol R Horowitz, Kadija Ferryman, Rennie Negron, Tatiana Sabin, Mayra Rodriguez, Randi F Zinberg, Erwin Böttinger, Mimsie Robinson
BACKGROUND: Variants of the APOL1 gene increase risk for kidney failure 10-fold, and are nearly exclusively found in people with African ancestry. To translate genomic discoveries into practice, we gathered information about effects and challenges incorporating genetic risk in clinical care. METHODS: An academic-community-clinical team tested 26 adults with self-reported African ancestry for APOL1 variants, conducting in-depth interviews about patients' beliefs and attitudes toward genetic testing- before, immediately, and 30 days after receiving test results...
2017: Journal of Health Care for the Poor and Underserved
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