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https://www.readbyqxmd.com/read/28205288/hematological-adverse-effects-and-pharmacokinetics-of-ribavirin-in-pigs-following-intramuscular-administration
#1
D-U Lee, S H Je, S J Yoo, T Kwon, J Y Shin, J J Byun, J-H Park, K-W Jeong, J-M Ku, Y S Lyoo
Ribavirin (RBV) is a synthetic guanosine analog that is used as a drug against various viral diseases in humans. The in vitro antiviral effects of ribavirin against porcine viruses were demonstrated in several studies. The purposes of this study were to evaluate the adverse effects and pharmacokinetics of ribavirin following its intramuscular (IM) injection in pigs. Ribavirin was formulated as a double-oil emulsion (RBV-DOE) and gel (RBV-Gel), which were injected into the pigs as single-dose IM injections...
February 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28192917/simple-reagentless-quantification-of-total-bilirubin-in-blood-via-microfluidic-phototreatment-and-image-analysis
#2
Brandon L Thompson, Sarah L Wyckoff, Doris M Haverstick, James P Landers
Total bilirubin (T-Bil) is an important clinical diagnostic marker that is measured frequently by physicians to assist in the diagnosis, treatment, and monitoring of multiple medical conditions. The work demonstrated here utilizes the 48-year-old mechanism of phototherapy that is commonly implemented in the treatment of infants with exaggerated physiologic and pathologic jaundice but adapts it to the microfluidic level for the ultimate purpose of total bilirubin quantitation. After acquisition of a small volume of blood (<10 μL) and through subsequent separation (plasma + red blood cells), a 3 μL plasma sample was imaged by a portable scanner and analyzed through a custom algorithm for color intensity...
February 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192141/glossoscolex-paulistus-hemoglobin-with-fluorescein-isothiocyanate-steady-state-and-time-resolved-fluorescence
#3
Ana E B Barros, Marina B Barioni, Francisco A O Carvalho, Amando Siuiti Ito, Marcel Tabak
Glossoscolex paulistus extracellular hemoglobin (HbGp) stability has been followed, in the presence of urea, using fluorescein isothiocyanate (FITC). Binding of FITC to HbGp results in a significant quenching of probe fluorescence. Tryptophan emission decays present four characteristic lifetimes: two in the sub-nanosecond/picosecond, and two in the nanosecond time ranges. Tryptophan decays for pure HbGp and HbGp-FITC systems are similar. In the absence of denaturant, and up to 2.5mol/L of urea, the shorter lifetimes predominate...
February 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28191913/treatment-with-the-glucagon-receptor-antagonist-ly2409021-increases-ambulatory-blood-pressure-in-patients-with-type-2-diabetes
#4
Christof M Kazda, Juan Frias, Irene Foga, Xuewei Cui, Cristina B Guzman, Parag Garhyan, Cory Heilmann, Jihui Anne Yang, Thomas A Hardy
AIMS: To assess the effect of LY2409021 on systolic blood pressure (SBP) in patients with type 2 diabetes. MATERIALS AND METHODS: This 6-week, randomized, crossover study evaluated the effects of once-daily administration of LY2409021 20 mg vs those of placebo on SBP, diastolic BP (DBP), and mean arterial pressure (MAP) using 24-hour ambulatory BP monitoring (ABPM) in 270 subjects treated with diet/exercise ± metformin. Other measures included changes in glycemic control, serum lipids, and hepatic safety markers...
February 13, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28187318/effect-of-maternal-cells-transferred-with-colostrum-on-the-health-of-neonate-calves
#5
Sylvia Marquart Fontes Novo, Juliana Fraça Dos Reis Costa, Camila Costa Baccili, Natália Meirelles Sobreira, Bruno Toledo Silva, Pamella Lorenci de Oliveira, David John Hurley, Viviani Gomes
The objective of this research was to evaluate the influence of cells from colostrum on the health of neonate calves. Animals were distributed in 2 groups: COL+ (n=9) which received fresh colostrum from their own damns; and COL- (n=10) which received frozen colostrums from donors. Heifers were assessed before colostrum intake - D0; D2; D7; D14; D21 and D28. Heifers were monitored by clinical examination, hematological profile and serum iron. COL- had a higher diarrhea intensity score (typically 3) on D7. Moreover, a single case each of bronchopneumonia and navel inflammation were observed in COL- calves...
January 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28186357/short-and-long-term-outcomes-with-renin-angiotensin-aldosterone-inhibitors-in-renal-transplant-recipients-a-meta-analysis-of-randomized-controlled-trials
#6
Ruo-Xi Liao, Xia-Fei Lyu, Wen-Jiao Tang, Kai Gao
BACKGROUND: Angiotensin-convertingenzyme inhibitors (ACEIs) and angiotensin II receptor type 1 blockers (ARBs) are often prescribed for renal transplant recipients (RTRs), but the outcomes of these medications in RTRs remain controversial. METHODS: The PubMed, Embase, and Cochrane Library databases were systematically searched. Randomized controlled trials investigating the outcomes of ACEI/ARBs in RTRs were included for meta-analysis. RESULTS: Twenty-two trials with 2242 patients were identified...
February 10, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28179465/variability-of-fasting-plasma-glucose-increased-risks-of-diabetic-polyneuropathy-in-t2dm
#7
Chun-Pai Yang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Kai-Lin Hwang, Sing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
OBJECTIVE: To examine whether variations in fasting plasma glucose (FPG), as measured by the coefficient of variation (CV), is a predictor of diabetic polyneuropathy (DPN) risk, considering glycated hemoglobin (HbA1c) and other traditional risk factors. METHODS: Type 2 diabetic patients enrolled in the National Diabetes Care Management Program were ≥30 years of age and free of DPN (n = 36,152). They were enrolled in 2002-2004 and were monitored until 2011. The related factors were analyzed using Cox proportional hazards regression models...
February 8, 2017: Neurology
https://www.readbyqxmd.com/read/28176508/a-structured-therapeutic-education-program-for-children-and-adolescents-with-type-1-diabetes-an-analysis-of-the-efficacy-of-the-pediatric-education-for-diabetes-project
#8
Alessandra Mauri, Susanna Schmidt, Valentina Sosero, Maria Sambataro, Laura Nollino, Francesco Fabris, Anna Corò, Antonella Scantamburlo, Michela Cazziola-Merlotto, Tania Ciani, Michele Tessarin, Agostino Paccagnella
BACKGROUND: Therapeutic education for Type 1 Diabetes involves the process of transmitting knowledge and developing the skills and behavior required to treat the disease. guidelines agree on stressing the importance of therapeutic educational intervention in teaching self-management skills to children and adolescents with Type 1 Diabetes (T1D). This study presents the results of the "Pediatric Education for Type 1 Diabetes (T1D)" (PED) project, specifically designed for children and adolescents aged 6 to 16, and structured on guidelines indications, as part of a broader clinical-educational intervention for Type 1 diabetes...
February 7, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28164640/unexpected-detection-of-hbh-cs-in-a-pregnant-woman-by-assessing-hba1c-using-capillary-electrophoresis
#9
Liangying Zhong, Miansheng Yan, Min Liu, Yingjun Xie, Lingling Xu, Linhuan Huang
BACKGROUND: Testing for hemoglobin A1C (HbA1C) is useful for following up on glycemic control in diabetic patients as well as in pregnant women. METHODS: A pregnant Chinese woman appeared for regular pregnancy check-ups. While monitoring blood glucose, an HbA1c test was initially performed in the pregnant Chinese woman using a CE-HPLC assay and capillary electrophoresis. Then acid gel Hb electrophoresis, a reverse dot-blot (RDB) assay, gap-PCR and DNA sequencing were applied to further evaluate the Hb variants...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28150363/blood-donation-and-testosterone-replacement-therapy
#10
Benjamin Chin-Yee, Alejandro Lazo-Langner, Terrie Butler-Foster, Cyrus Hsia, Ian Chin-Yee
BACKGROUND: Polycythemia is the most common adverse effect of testosterone replacement therapy (TRT) and may predispose patients to adverse vascular events. Current Canadian guidelines recommend regular laboratory monitoring and discontinuing TRT or reducing the dose if the hematocrit exceeds 54% (hemoglobin ≥180 g/L). This threshold has been interpreted by some physicians and patients to indicate the need for phlebotomy or blood donation while on TRT. STUDY DESIGN AND METHODS: We reviewed all male blood donors in Southwestern Ontario at Canadian Blood Services from December 2013 to March 2016 who self-identified or were found on donor screening to be on TRT...
February 1, 2017: Transfusion
https://www.readbyqxmd.com/read/28149024/extremely-high-ferritinemia-associated-with-haemophagocytic-lympho-histiocytosis-hlh
#11
Neelima Verma, Jyoti Chakraverty, Pankaj Baweja, Alka Girotra, Leena Chatterjee, Manish Chugh
Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28146680/prefrontal-hemodynamics-of-physical-activity-and-environmental-complexity-during-cognitive-work
#12
Ryan McKendrick, Ranjana Mehta, Hasan Ayaz, Melissa Scheldrup, Raja Parasuraman
OBJECTIVE: The aim of this study was to assess performance and cognitive states during cognitive work in the presence of physical work and in natural settings. BACKGROUND: Authors of previous studies have examined the interaction between cognitive and physical work, finding performance decrements in working memory. Neuroimaging has revealed increases and decreases in prefrontal oxygenated hemoglobin during the interaction of cognitive and physical work. The effect of environment on cognitive-physical dual tasking has not been previously considered...
February 2017: Human Factors
https://www.readbyqxmd.com/read/28145857/cytotoxicity-study-of-benzo-a-pyrene-on-blood-cells-of-wistar-rat-in-vitro
#13
J Zhang, Y Liu, S-Z Wei
The effect of benzo[a]pyrene (BaP) on Wistar rat lymphocyte activity, lymphocyle membrane integrity and erythrocytes hemolysis were examined using the MTT assay, the release of the lactate dehydrogenase (LD) and the hemoglobin release respectively in vitro. The results showed that lymphocyte activity had no remarkable response to BaP after a low dose of exposure. But the membrane change was found after higher dose of BaP exposure, and the significant release of LD was observed. The release of LD increased with exposure time prolonging and exposure dose increasing...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28123707/re-evaluation-of-glycated-hemoglobin-and-glycated-albumin-with-continuous-glucose-monitoring-system-as-markers-of-glycemia-in-patients-with-liver-cirrhosis
#14
Hiroshi Isoda, Hirokazu Takahashi, Yuichiro Eguchi, Motoyasu Kojima, Kanako Inoue, Kenichiro Murayama, Yayoi Matsuda, Keizo Anzai
Liver cirrhosis (LC) is frequently accompanied by glucose intolerance. The present study was designed to determine whether glycated hemoglobin A1c (HbA1c) and glycated albumin (GA) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (CGMS), in patients with LC. A total of 30 patients with LC, including 3, 19, 5, 2 and 1 with LC due to hepatitis B virus, hepatitis C virus, non-alcoholic steatohepatitis, alcohol and unknown causes, respectively, were assessed by CGMS. The average, maximum and minimum blood glucose (BG) levels were measured by CGMS, and correlated with HbA1c and GA...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28118454/continuous-glucose-monitoring-vs-conventional-therapy-for-glycemic-control-in-adults-with-type-1-diabetes-treated-with-multiple-daily-insulin-injections-the-gold-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Marcus Lind, William Polonsky, Irl B Hirsch, Tim Heise, Jan Bolinder, Sofia Dahlqvist, Erik Schwarz, Arndís Finna Ólafsdóttir, Anders Frid, Hans Wedel, Elsa Ahlén, Thomas Nyström, Jarl Hellman
Importance: The majority of individuals with type 1 diabetes do not meet recommended glycemic targets. Objective: To evaluate the effects of continuous glucose monitoring in adults with type 1 diabetes treated with multiple daily insulin injections. Design, Setting, and Participants: Open-label crossover randomized clinical trial conducted in 15 diabetes outpatient clinics in Sweden between February 24, 2014, and June 1, 2016 that included 161 individuals with type 1 diabetes and hemoglobin A1c (HbA1c) of at least 7...
24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28118453/effect-of-continuous-glucose-monitoring-on-glycemic-control-in-adults-with-type-1-diabetes-using-insulin-injections-the-diamond-randomized-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Roy W Beck, Tonya Riddlesworth, Katrina Ruedy, Andrew Ahmann, Richard Bergenstal, Stacie Haller, Craig Kollman, Davida Kruger, Janet B McGill, William Polonsky, Elena Toschi, Howard Wolpert, David Price
Importance: Previous clinical trials showing the benefit of continuous glucose monitoring (CGM) in the management of type 1 diabetes predominantly have included adults using insulin pumps, even though the majority of adults with type 1 diabetes administer insulin by injection. Objective: To determine the effectiveness of CGM in adults with type 1 diabetes treated with insulin injections. Design, Setting, and Participants: Randomized clinical trial conducted between October 2014 and May 2016 at 24 endocrinology practices in the United States that included 158 adults with type 1 diabetes who were using multiple daily insulin injections and had hemoglobin A1c (HbA1c) levels of 7...
24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28118412/whole-blood-donation-affects-the-interpretation-of-hemoglobin-a1c
#17
Angelique Dijkstra, Erna Lenters-Westra, Wim de Kort, Arlinke G Bokhorst, Henk J G Bilo, Robbert J Slingerland, Michel J Vos
INTRODUCTION: Several factors, including changed dynamics of erythrocyte formation and degradation, can influence the degree of hemoglobin A1c (HbA1c) formation thereby affecting its use in monitoring diabetes. This study determines the influence of whole blood donation on HbA1c in both non-diabetic blood donors and blood donors with type 2 diabetes. METHODS: In this observational study, 23 non-diabetic blood donors and 21 blood donors with type 2 diabetes donated 475 mL whole blood and were followed prospectively for nine weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28116117/predictive-factors-for-effectiveness-and-safety-of-enoxaparin-for-total-knee-arthroplasty-in-aged-japanese-patients-a-retrospective-review
#18
Akihiro Sonoda, Yuki Kondo, Yasuhiro Tsuneyoshi, Yoshitaka Iwashita, Shoji Nakao, Kazuhisa Ishida, Kentaro Oniki, Junji Saruwatari, Tetsumi Irie, Yoichi Ishitsuka
BACKGROUND: The aims of this study were to investigate predictive factors involved in effectiveness and safety of enoxaparin for prevention of postoperative venous thromboembolism in aged Japanese total knee arthroplasty (TKA) patients. METHODS: Japanese patients over 65 years old who were administered enoxaparin for TKA were enrolled in this study. Their medical records were retrospectively reviewed. Data were corrected at the Izumi Regional Medical Center, from September 2009 to March 2014...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28112871/quantification-by-nano-liquid-chromatography-parallel-reaction-monitoring-mass-spectrometry-of-human-apolipoprotein-a-i-apolipoprotein-b-and-hemoglobin-a1c-in-dried-blood-spots
#19
Clark M Henderson, James G Bollinger, Jessica O Becker, Jennifer M Wallace, Thomas J Laha, Michael J MacCoss, Andrew N Hoofnagle
PURPOSE: Proteomic analysis of blood proteins in DBS is gaining attention as a possible replacement for measurements in plasma/serum collected by venipuncture. We aimed to develop and provisionally validate a nanoflow LC-PRM-MS method for clinical use. EXPERIMENTAL DESIGN: We used Skyline to develop a nanoflow LC-PRM-MS method to quantify glycated hemoglobin-β, apolipoprotein A-I, and apolipoprotein B in DBS. Precision, linearity, interferences, and stability and were determined and the method was used to analyze samples from 36 human volunteers...
January 23, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28109022/itpa-polymorphism-correlates-with-the-reductions-in-hemoglobin-concentration-and-ribavirin-dose-during-sofosbuvir-and-ribavirin-therapy
#20
Ritsuzo Kozuka, Hoang Hai, Yuga Teranishi, Hiroyuki Motoyama, Etsushi Kawamura, Atsushi Hagihara, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Masaru Enomoto, Yoshiki Murakami, Norifumi Kawada, Akihiro Tamori
BACKGROUND AND AIM: It is unclear whether polymorphism in the inosine triphosphatase (ITPA) gene correlates with the reduction in hemoglobin (Hb) concentrations during sofosbuvir (SOF) and ribavirin (RBV) therapy. We investigated the effects of the ITPA polymorphism in Japanese patients with chronic hepatitis C virus genotype 2 infection treated with SOF/RBV therapy. METHODS: In 106 patients treated with SOF/RBV therapy, we assessed the effects of the ITPA polymorphism (rs1127354) on anemia, RBV dose reduction, and sustained virological response (SVR)...
January 20, 2017: Journal of Gastroenterology and Hepatology
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