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https://www.readbyqxmd.com/read/28729114/altered-intrinsic-functional-connectivity-in-the-latent-period-of-epileptogenesis-in-a-temporal-lobe-epilepsy-model
#1
Hyoin Lee, Seungmoon Jung, Peter Lee, Yong Jeong
The latent period, a seizure-free phase, is the duration between brain injury and the onset of spontaneous recurrent seizures (SRSs) during epileptogenesis. The latent period is thought to involve several progressive pathophysiological events that lead to the evolution of the chronic epilepsy phase. Hence, it is vital to investigate the changes in the latent period during epileptogenesis in order to better understand temporal lobe epilepsy (TLE), and to achieve early diagnosis and appropriate management of the condition...
July 17, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28728402/influence-of-body-condition-score-at-calving-on-the-metabolic-status-and-production-performance-of-murrah-buffaloes-bubalus-bubalis-during-the-transition-period
#2
Nelson Carvalho Delfino, Lucas Fialho de Aragão Bulcão, Henry Daniel Ruiz Alba, Mauricio Xavier da Silva Oliveira, Filipe Pinheiro Soares de Queiroz, Gleidson Giordano Pinto de Carvalho, Francisco Palma Rennó, José Esler Freitas Júnior
Objective: The purpose of this study was to evaluate the influence of body condition score (BCS) at calving on the metabolic status of female Murrah buffaloes in the transition period. Methods: Thirty-seven pregnant buffaloes (multiparous) were selected and monitored during the transition period based on their body condition score and on the estimated calving date. Two groups were formed: 1) buffaloes with a BCS > 3.5 (n = 17); this group was classified and named 'high BCS at calving' (HBCS); and 2) buffaloes with a BCS ≤ 3...
July 17, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28727608/evaluation-of-non-invasive-hemoglobin-monitoring-in-trauma-patients-with-low-hemoglobin-levels
#3
Medhat Gamal, Bassant Abdelhamid, Dina Zakaria, Omnia Abd El Dayem, Ashraf Rady, Maher Fawzy, Ahmed Hasanin
OBJECTIVE: Bleeding is a leading cause of death among trauma patients. Delayed assessment of blood hemoglobin level might result in either unnecessary blood transfusion in non-indicated patients or delayed blood transfusion in critically bleeding patients. In this study, we evaluate the precision of non-invasive hemoglobin monitoring in trauma patients with low hemoglobin levels. METHODS: We included trauma patients with low hemoglobin levels (less than 8 g/dL) scheduled for surgical intervention...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28725273/a-randomized-controlled-trial-comparing-the-effects-of-dapagliflozin-and-dpp-4-inhibitors-on-glucose-variability-and-metabolic-parameters-in-patients-with-type-2-diabetes-mellitus-on-insulin
#4
Hiroshi Nomoto, Hideaki Miyoshi, Hajime Sugawara, Kota Ono, Shingo Yanagiya, Mayuko Oita, Akinobu Nakamura, Tatsuya Atsumi
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors improve hyperglycemia, and the usefulness of co-administration of DPP-4 inhibitors and insulin therapy has been well established. However, it has been still uncertain whether combination therapy of SGLT2 inhibitors and insulin is superior to that of DPP-4 inhibitors and the latter. Therefore, we investigated the superiority of dapagliflozin on glucose fluctuation compared with DPP-4 inhibitors in patients with type 2 diabetes mellitus (T2DM) on insulin using a continuous glucose monitoring (CGM) system...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28725115/maternal-and-fetal-arterial-blood-gas-data-in-normotensive-singleton-isoflurane-anesthetized-sheep-at-124-126-days-of-gestation
#5
Claire M Loughran, Matthew W Kemp, Gabrielle C Musk
The aim of this case series was to describe the differences between maternal and fetal blood-gas results during anesthesia. Sixteen singleton adult merino ewes weighing 60.1 ± 5.1 kg at 125.7 d (124 to 126 d) gestation were anesthetized. Maternal (radial) and fetal (umbilical) arterial blood gas samples were collected 79 ± 6 min after the start of anesthesia if maternal mean arterial pressure (MAP) was stable and > 65 mmHg. Fetal pH, partial arterial pressure of oxygen (PaO2), glucose, arterial hemoglobin oxygen saturation (SaO2), sodium, and chloride were significantly lower and fetal partial arterial pressure of carbon dioxide (PaCO2), lactate, hematocrit, total hemoglobin, potassium, and calcium were significantly higher than maternal blood-gas values...
July 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28721978/noninvasive-biomarkers-as-surrogate-predictors-of-clinical-and-endoscopic-remission-after-infliximab-induction-in-patients-with-refractory-ulcerative-colitis
#6
Elham A Hassan, Haidi K Ramadan, Ali A Ismael, Khaled F Mohamed, Madiha M El-Attar, Ihab Alhelali
BACKGROUND/AIMS: Treatment of refractory ulcerative colitis (UC) is a clinical challenge, and after biological therapy, monitoring clinical and endoscopic responses is fundamental. We aimed to investigate and compare the predictive power of different noninvasive parameters for clinical remission and mucosal healing after infliximab induction therapy in refractory UC patients. PATIENTS AND METHODS: Serum and fecal biomarkers, including hemoglobin, white blood cells, erythrocyte sedimentation rate, C-reactive protein (CRP), and fecal calprotectin (FC), and colonoscopy were assessed in 44 patients with refractory UC before and after (week 12) infliximab induction...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28715941/moderate-anemia-at-diagnosis-is-an-independent-prognostic-marker-of-the-eutos-sokal-and-hasford-scores-for-survival-and-treatment-response-in-chronic-phase-chronic-myeloid-leukemia-patients-with-frontline-imatinib
#7
Po-Shen Ko, Yuan-Bin Yu, Yao-Chung Liu, Yi-Tsui Wu, Man-Hsin Hung, Jyh-Pyng Gau, Chia-Jen Liu, Liang-Tsai Hsiao, Po-Min Chen, Tzeon-Jye Chiou, Chun-Yu Liu, Jin-Hwang Liu
OBJECTIVES: We aimed to examine the prognostic value of anemia for the diagnosis of chronic myeloid leukemia in the chronic phase (CML-CP) receiving imatinib. METHODS: One hundred fifty-four CML-CP patients were enrolled. The influences of moderate anemia with hemoglobin (Hb) < 10 g/dl, four scoring systems and the early molecular response at three months (BCR-ABL ≤ 10%; 3M-EMR) on the achievement of a deep molecular response (DMR, MR4.5), progression-free survival (PFS), event-free survival (EFS) and overall survival (OS) were compared...
July 18, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28715342/quantitative-evaluation-of-rehabilitation-effect-on-peripheral-circulation-of-diabetic-foot
#8
Yao-Kuang Huang, Chang-Cheng Chang, Pin-Xing Lin, Bor-Shyh Lin
Diabetics may encounter different foot problems, which easily lead to infection, ulcers, and increased risk of amputation due to nerve or vascular injury. In order to reduce the risk of amputation, Buerger's exercise is one of the frequently used rehabilitation to improve the blood circulation in the lower limbs. However, it is difficult to evaluate the rehabilitation efficiency of Buerger's exercise objectively. In this study, a novel non-invasively optical system was developed to non-invasively monitor the change of the foot blood circulation before and after long-term Buerger's exercise...
July 13, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28713663/correlation-between-glycated-hemoglobin-and-triglyceride-level-in-type-2-diabetes-mellitus
#9
Syeda Naqvi, Shabnam Naveed, Zeeshan Ali, Syed Masroor Ahmad, Raad Asadullah Khan, Honey Raj, Shoaib Shariff, Chintan Rupareliya, Fatima Zahra, Saba Khan
CONTEXT: Dyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PURPOSE: The main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events...
June 13, 2017: Curēus
https://www.readbyqxmd.com/read/28702091/educ-dom-comparative-study-of-the-telemonitoring-of-patients-with-type-2-diabetes-versus-standard-monitoring-study-protocol-for-a-randomized-controlled-study
#10
Marie-Christine Turnin, Solène Schirr-Bonnans, Jacques Martini, Jean-Christophe Buisson, Soumia Taoui, Marie-Christine Chauchard, Nadège Costa, Benoît Lepage, Laurent Molinier, Hélène Hanaire
BACKGROUND: The global prevalence of type 2 diabetes is considerable. To avoid or delay its chronic complications, patients with type 2 diabetes should improve blood glucose management by adapting their life style. This involves changing the way in which diabetes is controlled. We believe that, thanks to technological innovations in connected health-monitoring devices, the telemonitoring of type 2 diabetes patients using therapeutic educational tools is likely to help them adapt their treatment and lifestyle habits, and therefore improve blood glucose management...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28701789/mental-workload-and-neural-efficiency-quantified-in-the-prefrontal-cortex-using-fnirs
#11
Mickaël Causse, Zarrin Chua, Vsevolod Peysakhovich, Natalia Del Campo, Nadine Matton
An improved understanding of how the brain allocates mental resources as a function of task difficulty is critical for enhancing human performance. Functional near infrared spectroscopy (fNIRS) is a field-deployable optical brain monitoring technology that provides a direct measure of cerebral blood flow in response to cognitive activity. We found that fNIRS was sensitive to variations in task difficulty in both real-life (flight simulator) and laboratory settings (tests measuring executive functions), showing increased concentration of oxygenated hemoglobin (HbO2) and decreased concentration of deoxygenated hemoglobin (HHb) in the prefrontal cortex as the tasks became more complex...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699985/glycated-albumin-a-potential-biomarker-in-diabetes
#12
Priscila Aparecida Correa Freitas, Lethicia Rozales Ehlert, Joíza Lins Camargo
Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels...
May 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28692996/effectiveness-evaluation-of-real-time-scalp-signal-separating-algorithm-on-near-infrared-spectroscopy-neurofeedback
#13
Wei Chun Ung, Tsukasa Funane, Takushige Katura, Hiroki Sato, Tong Boon Tang, Ahmad Fadzil Mohammad Hani, Masashi Kiguchi
Near-infrared spectroscopy (NIRS), one of the candidates to be used in a neurofeedback system or brain-computer interface (BCI), measures the brain activity by monitoring the changes in cerebral hemoglobin concentration. However, hemodynamic changes in the scalp may affect the NIRS signals. In order to remove the superficial signals when NIRS is used in a neurofeedback system or BCI, real-time processing is necessary. Real-time scalp signal separating (RT-SSS) algorithm, which is capable of separating the scalp-blood signals from NIRS signals obtained in real-time, may thus be applied...
July 4, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28689084/regional-variations-in-frequency-of-glycosylated-hemoglobin-hba1c-monitoring-in-korea-a-multilevel-analysis-of-nationwide-data
#14
Kyoung-Hun Yoo, Dong-Wook Shin, Mi-Hee Cho, Sang-Hyuck Kim, Hyun-Jung Bahk, Shin-Hye Kim, Su-Min Jeong, Jae-Moon Yun, Jin-Ho Park, Heesun Kim, BeLong Cho
PURPOSE: Suboptimal frequency of glycosylated hemoglobin (HbA1c) monitoring is associated with poor diabetes control. We aimed to analyze compliance to HbA1c testing guidelines and explore associated individual and area-level determinants, focusing on regional variation. METHODS: This cross-sectional study between the period of 2012-2013 was conducted by using the Korean National Health Insurance Research Database, and included 45,634 patients diagnosed with diabetes mellitus, who were prescribed any anti-diabetic medications, including insulin...
June 23, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28685513/effects-of-vildagliptin-or-pioglitazone-on-glycemic-variability-and-oxidative-stress-in-patients-with-type-2-diabetes-inadequately-controlled-with-metformin-monotherapy-a-16-week-randomised-open-label-pilot-study
#15
Nam Hoon Kim, Dong Lim Kim, Kyeong Jin Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim
BACKGROUND: Glycemic variability is associated with the development of diabetic complications through the activation of oxidative stress. This study aimed to evaluate the effects of a dipeptidyl peptidase 4 inhibitor, vildagliptin, or a thiazolidinedione, pioglitazone, on glycemic variability and oxidative stress in patients with type 2 diabetes. METHODS: In this open label, randomised, active-controlled, pilot trial, individuals who were inadequately controlled with metformin monotherapy were assigned to either vildagliptin (50 mg twice daily, n=17) or pioglitazone (15 mg once daily, n=14) treatment groups for 16 weeks...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28685453/tissue-blood-volume-parameters-measured-by-continuous-wave-and-spatially-resolved-nirs-show-different-changes-during-prolonged-cycling-exercise
#16
Takuya Osawa, Keisuke Shiose, Hideyuki Takahashi
Near-infrared spectroscopy (NIRS) shows two types of tissue blood volume (BV) parameters: the total hemoglobin concentration (cHb; assessed by continuous-wave NIRS) and the normalized tissue hemoglobin index (nTHI; evaluated by spatially resolved NIRS). This study was performed to investigate the differences between cHb and nTHI, estimated by calibration using acute reduction of BV at the onset of exercise. Seven active male volunteers (age: 22  ±  4 years) performed a prolonged (60-min) cycling exercise test at 65% or 70% of the peak oxygen uptake...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685440/age-related-changes-in-physiological-reactivity-to-a-stress-task-a-near-infrared-spectroscopy-study
#17
A Brugnera, C Zarbo, R Adorni, A Gatti, A Compare, K Sakatani
Aging is associated with changes in biological functions, such as reduced cardiovascular responses to stressful tasks. However, less is known about the influence of age on the reactivity of the prefrontal cortex (PFC) to acute stressors. Therefore, this study aimed to investigate the effects of a computerized-controlled stress task on the PFC and autonomic system activity in a sample of older and younger adults. We recruited a total of 55 healthy, right-handed persons (26 older adults with mean age 69.5, SD 5...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685426/effects-of-8-weeks-training-on-systemic-and-muscle-oxygen-dynamics-in-university-rugby-players
#18
Shun Takagi, Ryotaro Kime, Masatsugu Niwayama, Kuniaki Hirayama, Shizuo Sakamoto
The aim of this study was to investigate the effects of 8 weeks of training on O2 dynamics in university rugby players. University rugby players (n = 15) participated in 5 strength training sessions and 4 field-based training sessions per week for 8 weeks. Before and after 8-weeks' training, the subjects performed ramp cycling exercise until exhaustion. Muscle O2 saturation (SmO2), relative changes from rest in deoxygenated hemoglobin concentration (∆Deoxy-Hb) and total hemoglobin concentration, cardiac output (CO), and pulmonary O2 uptake (VO2) were monitored continuously during exercise...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685425/multi-site-measurements-of-muscle-o2-dynamics-during-cycling-exercise-in-early-post-myocardial-infarction
#19
Shun Takagi, Ryotaro Kime, Norio Murase, Masatsugu Niwayama, Takuya Osada, Toshihito Katsumura
The aim of this study was to compare the muscle oxygen dynamics between early post-myocardial infarction (n = 12; MI) and age-matched elderly subjects without MI (n = 12; CON) in several leg muscles during ramp cycling exercise. Muscle oxygen saturation (SmO2), deoxygenated-hemoglobin concentration (∆deoxy-Hb), and total-hemoglobin concentration (∆total-Hb) were monitored continuously at the distal site of vastus lateralis (VLd), proximal site of the vastus lateralis (VLp), rectus femoris (RF), vastus medialis (VM), gastrocnemius medialis (GM), and tibialis anterior (TA) muscles by near infrared spatial resolved spectroscopy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28683773/determinants-and-time-to-blood-transfusion-among-thermal-burn-patients-admitted-to-mulago-hospital
#20
C Kilyewala, R Alenyo, R Ssentongo
BACKGROUND: Blood transfusion, a practice under re-evaluation in general, remains common among thermal burn patients due to the hematological alterations associated with burns that manifest as anemia. Today advocacy is for restrictive blood transfusion taking into account individual patient characteristics. We went out to identify the parameters that may determine transfusion requirement and the time to blood transfusion for thermal burn patients in Mulago Hospital in order to build statistics and a basis to standardize future practice and Hospital protocol...
July 6, 2017: BMC Research Notes
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