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https://www.readbyqxmd.com/read/27814710/methemoglobin-and-nitric-oxide-therapy-in-ugandan-children-hospitalized-for-febrile-illness-results-from-a-prospective-cohort-study-and-randomized-double-blind-placebo-controlled-trial
#1
Andrea L Conroy, Michael Hawkes, Kyla Hayford, Laura Hermann, Chloe R McDonald, Suparna Sharma, Sophie Namasopo, Robert O Opoka, Chandy C John, W Conrad Liles, Christopher Miller, Kevin C Kain
BACKGROUND: Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues. There are no reliable estimates of methemoglobinemia in low resource clinical settings. Our objectives were to: i) evaluate risk factors for methemoglobinemia in Ugandan children hospitalized with fever (study 1); and ii) investigate MHb responses in critically ill Ugandan children with severe malaria treated with inhaled nitric oxide (iNO), an oxidant that induces MHb in a dose-dependent manner (study 2)...
November 4, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27717357/perfusion-index-assessment-during-transition-period-of-newborns-an-observational-study
#2
Sezin Unal, Ebru Ergenekon, Selma Aktas, Serdar Beken, Nilgun Altuntas, Ebru Kazanci, Ferit Kulali, Ibrahim M Hirfanoglu, Esra Onal, Canan Turkyilmaz, Esin Koc, Yildiz Atalay
BACKGROUND: Perfusion index (PI) is becoming a part of clinical practice in neonatology to monitor peripheral perfusion noninvasively. Hemodynamic and respiratory changes occur in newborns during the transition period after birth in which peripheral perfusion may be affected. Tachypnea is a frequent symptom during this period. While some tachypneic newborns get well in less than 6 h and diagnosed as "delayed transition", others get admitted to intensive care unit which transient tachypnea of newborn (TTN) being the most common diagnosis among them...
October 7, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27665572/evaluation-of-perfusion-index-as-a-tool-for-pain-assessment-in-critically-ill-patients
#3
Ahmed Hasanin, Sabah Abdel Raouf Mohamed, Akram El-Adawy
Pain is a common and undertreated problem in critically ill patients. Pain assessment in critically ill patients is challenging and relies on complex scoring systems. The aim of this work was to find out the possible role of the perfusion index (PI) measured by a pulse oximeter (Masimo Radical 7; Masimo Corp., Irvine, CA, USA) in pain assessment in critically ill patients. A prospective observational study was carried out on 87 sedated non-intubated patients in a surgical intensive care unit. In addition to routine monitoring, a Masimo pulse oximeter probe was used for PI measurement...
September 24, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27549603/methemoglobin-measurements-are-underestimated-by-the-radical-7-co-oximeter-experience-from-a-series-of-moderate-to-severe-propanil-poisonings
#4
Elspeth Hulse, Fathima Shihana, Nicholas A Buckley
INTRODUCTION: In Asia methemoglobinemia (MetHb) is commonly caused through self-poisoning with the pesticide propranil. MetHb can cause hypoxia, coma and death, but usually responds to methylene blue. It is therefore vital to have accurate methods to measure blood MetHb to guide appropriate treatments. The gold standard to measure MetHb utilizes a spectrophotometer, but recent bedside tests have been developed e.g., pulse co-oximeter probe and blood color chart. METHODS: Nine propanil poisoned patients had data collected from hospitals in Sri Lanka during 2008...
November 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27501120/noninvasive-continuous-hemoglobin-monitoring-in-combat-casualties-a-pilot-study
#5
Elizabeth Bridges, Jennifer J Hatzfeld
OBJECTIVE: To describe the accuracy and precision of noninvasive hemoglobin measurement (SpHb) compared with laboratory or point-of-care Hb, and SpHb ability to trend in seriously injured casualties. METHODS: Observational study in a convenience sample of combat casualties undergoing resuscitation at two US military trauma hospitals in Afghanistan. SpHb was obtained using the Masimo Rainbow SET (Probe Rev E/Radical-7 Pulse CO-Oximeter v 7.6.2.1). Clinically indicated Hb was analyzed with a Coulter or iStat and compared with simultaneous SpHb values...
September 2016: Shock
https://www.readbyqxmd.com/read/27450027/evaluation-of-pleth-variability-index-as-a-predictor-of-fluid-responsiveness-during-orthotopic-liver-transplantation
#6
Huseyin Konur, Gulay Erdogan Kayhan, Huseyin Ilksen Toprak, Nizamettin Bucak, Mustafa Said Aydogan, Saim Yologlu, Mahmut Durmus, Sezai Yılmaz
Fluid management is challenging and still remains controversial in orthotopic liver transplantation (OLT). The pleth variability index (PVI) has been shown to be a reliable predictor of fluid responsiveness of perioperative and critically ill patients; however, it has not been evaluated in OLT. This study was designed to examine whether the PVI can reliably predict fluid responsiveness in OLT and to compare PVI with other hemodynamic indexes that are measured using the PiCCO2 monitoring system. Twenty-five patients were enrolled in this study...
July 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27320555/pulse-oximeter-derived-pleth-variability-index-is-a-reliable-indicator-of-cardiac-preload-in-patients-undergoing-liver-transplantation
#7
H-C Lee, Y-F Tsai, H-I Tsai, P C-H Chung, H-P Yu, W-C Lee, C-C Lin
BACKGROUND: Accurate estimation of cardiac preload during liver transplantation is essential. The right ventricular end-diastolic volume index (RVEDVI) is recognized as a good preload indicator in patients undergoing liver transplantation. Recently, dynamic variation parameters including pleth variability index (PVI) have been used as predictors of fluid responsiveness. However, the correlation between PVI and preload status has not been well studied. We evaluated the relationship between PVI and RVEDVI during liver transplantation...
May 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27270963/acoustic-sensor-versus-electrocardiographically-derived-respiratory-rate-in-unstable-trauma-patients
#8
Shiming Yang, Ashley Menne, Peter Hu, Lynn Stansbury, Cheng Gao, Nicolas Dorsey, William Chiu, Stacy Shackelford, Colin Mackenzie
Respiratory rate (RR) is important in many patient care settings; however, direct observation of RR is cumbersome and often inaccurate, and electrocardiogram-derived RR (RRECG) is unreliable. We asked how data derived from the first 15 min of RR recording after trauma center admission using a novel acoustic sensor (RRa) would compare to RRECG and to end-tidal carbon dioxide-based RR ([Formula: see text]) from intubated patients, the "gold standard" in predicting life-saving interventions in unstable trauma patients...
June 7, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27167058/predicting-stroke-volume-and-arterial-pressure-fluid-responsiveness-in-liver-cirrhosis-patients-using-dynamic-preload-variables-a-prospective-study-of-diagnostic-accuracy
#9
Chun-Yu Wu, Ya-Jung Cheng, Ying-Ju Liu, Tsung-Ta Wu, Chiang-Ting Chien, Kuang-Cheng Chan
BACKGROUND: Predicting whether a fluid challenge will elicit 'fluid responsiveness' in stroke volume (SV) and arterial pressure is crucial for managing hypovolaemia and hypotension. Pulse pressure variation (PPV), SV variation (SVV) and the plethysmographic variability index (PVI) have been shown to predict SV fluid responsiveness, and the PPV/SVV ratio has been shown to predict arterial pressure fluid responsiveness under various conditions. However, these variables have not been investigated in liver cirrhosis patients...
September 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27124843/oximetry-for-preterm-infants-at-neonatal-discharge-what-is-current-practice-in-new-zealand-and-australia
#10
Grace Wellington, Angela J Campbell, Dawn E Elder
AIM: The aim of the study was to survey level 2 and 3 neonatal units in Australasia to determine the prevalence of oximetry studies at discharge for preterm infants, how these oximetry studies are performed, and which measures are included in an oximetry report. METHODS: A 10-question online survey was created using Survey Monkey regarding use of predischarge oximetry and e-mailed to 46 neonatal units (all level 2 and three units in NZ and all level 3 units in Australia)...
March 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/26978143/oxygen-reserve-index-a-novel-noninvasive-measure-of-oxygen-reserve-a-pilot-study
#11
Peter Szmuk, Jeffrey W Steiner, Patrick N Olomu, Roxana P Ploski, Daniel I Sessler, Tiberiu Ezri
BACKGROUND: Pulse oximetry provides no indication of downward trends in PaO2 until saturation begins to decrease. The Oxygen Reserve Index (ORI) is a novel pulse oximeter-based nondimensional index that ranges from 1 to 0 as PaO2 decreases from about 200 to 80 mmHg and is measured by optically detecting changes in SvO2 after SaO2 saturates to the maximum. The authors tested the hypothesis that the ORI provides a clinically important warning of impending desaturation in pediatric patients during induction of anesthesia...
April 2016: Anesthesiology
https://www.readbyqxmd.com/read/26951394/adaptation-to-life-in-the-high-andes-nocturnal-oxyhemoglobin-saturation-in-early-development
#12
Catherine Mary Hill, Ana Baya, Johanna Gavlak, Annette Carroll, Kate Heathcote, Dagmara Dimitriou, Veline L'Esperance, Rebecca Webster, John Holloway, Javier Virues-Ortega, Fenella Jane Kirkham, Romola Starr Bucks, Alexandra Marie Hogan
STUDY OBJECTIVES: Physiological adaptation to high altitude hypoxia may be impaired in Andeans with significant European ancestry. The respiratory 'burden' of sleep may challenge adaptation, leading to relative nocturnal hypoxia. Developmental aspects of sleep-related breathing in high-altitude native children have not previously been reported. We aimed to determine the influence of development on diurnal-nocturnal oxyhemoglobin differences in children living at high altitude. METHODS: This was a cross-sectional, observational study...
2016: Sleep
https://www.readbyqxmd.com/read/26914626/accuracy-of-pulse-oximeters-intended-for-hypoxemic-pediatric-patients
#13
Bronwyn U Harris, Danton S Char, Jeffrey A Feinstein, Archana Verma, Stephen C Shiboski, Chandra Ramamoorthy
OBJECTIVES: Prior studies have shown inaccuracies in pulse oximetry readings at saturations less than 85%; however, no large studies have evaluated new sensors marketed for these low saturations. This study's purpose was to evaluate two sensors with claims of improved accuracy in children with saturations less than 85%. DESIGN: Prospective observational study. SETTING: Single institution; cardiac catheterization laboratory, and operating room...
April 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26759335/acoustic-method-respiratory-rate-monitoring-is-useful-in-patients-under-intravenous-anesthesia
#14
Kentaro Ouchi, Shigeki Fujiwara, Kazuna Sugiyama
Respiratory depression can occur during intravenous general anesthesia without tracheal intubation. A new acoustic method for respiratory rate monitoring, RRa(®) (Masimo Corp., Tokyo, Japan), has been reported to show good reliability in post-anesthesia care and emergency units. The purpose of this study was to investigate the reliability of the acoustic method for measurement of respiratory rate during intravenous general anesthesia, as compared with capnography. Patients with dental anxiety undergoing dental treatment under intravenous anesthesia without tracheal intubation were enrolled in this study...
January 12, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26686689/accuracy-of-non-invasive-continuous-total-hemoglobin-measurement-by-pulse-co-oximetry-in-severe-traumatized-and-surgical-bleeding-patients
#15
Werner Baulig, Burkhardt Seifert, Donat R Spahn, Oliver M Theusinger
The Masimo Radical-7 Pulse CO-Oximeter (Masimo Corp., USA) non-invasively computes hemoglobin concentration (SpHb). SpHb was compared to Co-Oximeter readings (CoOxHb) of arterial samples in surgery patients of the emergency department. Forty-six patients were enrolled. The Masimo R1 25L (revision F and G) adult adhesive sensor was attached to the ring finger of the arterially cannulated hand. Before start, every 30 min during surgery and in the case of severe bleeding SpHb and CoOxHb values were documented...
December 19, 2015: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26611218/carbon-monoxide-exposure-in-norwegian-rescue-helicopters
#16
Michael Busch
OBJECTIVE: Exposure to exhaust fumes from combustion engines can lead to carbon monoxide (CO) poisoning. Sea King Rescue helicopter crews are frequently subjected to engine exhaust. This study investigates the extent of CO exposure and potential for intoxication for flight crews during standard operational training procedures. METHODS: Over a 2-week period, rescue helicopter flight crews were monitored for exposure to exhaust fumes and clinical symptoms of CO intoxication by means of a written survey and measurements of carboxyhemoglobin saturation (SpCO) with a handheld pulse CO oximeter (RAD-57; Masimo, Irvine, CA)...
November 2015: Air Medical Journal
https://www.readbyqxmd.com/read/26471067/accuracy-of-the-masimo-set%C3%A2-lncs-neo-peripheral-pulse-oximeter-in-cyanotic-congenital-heart-disease
#17
Michael J Griksaitis, Gemma E Scrimgeour, John V Pappachan, Andrew J Baldock
UNLABELLED: Introduction Non-invasive peripheral pulse oximeters are routinely used to measure oxyhaemoglobin saturation (SpO2) in cyanotic congenital heart disease. These probes are calibrated in healthy adult volunteers between arterial saturations of ~75 and 100%, using the gold standard of co-oximetry on arterial blood samples. There are little data to attest their accuracy in cyanotic congenital heart disease. Aims We aimed to assess the accuracy of a commonly used probe in children with cyanotic congenital heart disease...
August 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/26364905/bronchiolitis-of-infancy-discharge-study-bids-a-multicentre-parallel-group-double-blind-randomised-controlled-equivalence-trial-with-economic-evaluation
#18
RANDOMIZED CONTROLLED TRIAL
Steve Cunningham, Aryelly Rodriguez, Kathleen A Boyd, Emma McIntosh, Steff C Lewis
BACKGROUND: There are no randomised trials of peripheral capillary oxygen saturation (SpO2) targets in acute respiratory infection. Two national guidelines recommended different targets for the management of acute viral bronchiolitis. OBJECTIVES: To compare the American Academy of Pediatrics guideline target of SpO2 ≥ 90% with the Scottish Intercollegiate Guidelines Network target of SpO2 ≥ 94%. DESIGN: A multicentre, parallel-group, double-blind, randomised controlled, equivalence trial with economic evaluation...
September 2015: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26332278/support-for-support
#19
EDITORIAL
Jeffrey M Drazen, Caren G Solomon, Stephen Morrissey, Michael F Greene
On August 13, 2015, Karon Owen Bowdre, Chief Judge of the U.S. District Court for the Northern District of Alabama, dismissed without trial the case brought against the University of Alabama institutional review board (IRB), the principal investigator, and the electronics firm Masimo by plaintiffs..
October 8, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26282827/algorithms-that-eliminate-the-effects-of-calibration-artefact-and-trial-imposed-offsets-of-masimo-oximeter-in-boost-nz-trial
#20
Marina Zahari, Dominic Savio Lee, Brian Alexander Darlow
The displayed readings of Masimo pulse oximeters used in the Benefits Of Oxygen Saturation Targeting (BOOST) II and related trials in very preterm babies were influenced by trial-imposed offsets and an artefact in the calibration software. A study was undertaken to implement new algorithms that eliminate the effects of offsets and artefact. In the BOOST-New Zealand trial, oxygen saturations were averaged and stored every 10 s up to 36 weeks' post-menstrual age. Two-hundred and fifty-seven of 340 babies enrolled in the trial had at least two weeks of stored data...
October 2016: Journal of Clinical Monitoring and Computing
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