Dulce Maria Nascimento Coelho, Dilailson Carlos Costa Júnior, Daniel Moreira Alves da Silva, Ana Carolina Benício Alves, Raquell de Castro Chaves, Manoela de Oliveira Rebouças, José Tiago Valentim, Andressa Alexandre de Oliveira, Iardja Stefane Lopes Sales, Lucas Antonio Duarte Nicolau, Francisca Cléa Florenço de Sousa
Chronic use of omeprazole has been linked to central effects alongside with the global concern of increasing appearance of neuropsychiatric disorders. This study aimed to identifying behavioral, inflammatory, and oxidative stress alterations after long-term administration of omeprazole. C57BL/6 mice were divided in groups: OME and Sham, each received either solutions of omeprazole or vehicle, administered for 28 days by gavage. Results observed in the omeprazole-treated mice: Decrease in the crossing parameter in the open field, no change in the motor performance assessed by rotarod, an immobility time reduction in the forced swimming test, improved percentage of correct alternances in the Ymaze and an exploration time of the novel object reduction in the novel object recognition...
March 4, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology