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https://www.readbyqxmd.com/read/28231529/new-enantioselective-lc-method-development-and-validation-for-the-assay-of-modafinil
#1
Marianna Harvanová, Taťána Gondová
For the first time, a new, fast and sensitive chromatographic method for the separation and determination of modafinil enantiomers was developed on chiral stationary phase with macrocyclic glycopeptide teicoplanin in the polar organic mode. The effect of the mobile phase composition and column temperature on the retention and enantioseparation were studied. The separation was performed using a Chirobiotic T column (250×4.6mm, 5μm) with methanol and triethylamine (100/0.05, v/v) as the mobile phase at a flow rate of 1...
February 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28231277/comparison-of-cross-sectional-hiv-incidence-assay-results-from-dried-blood-spots-and-plasma
#2
Katherine E Schlusser, Christopher Pilcher, Esper G Kallas, Breno R Santos, Steven G Deeks, Shelley Facente, Sheila M Keating, Michael P Busch, Gary Murphy, Alex Welte, Thomas Quinn, Susan H Eshleman, Oliver Laeyendecker
BACKGROUND: Assays have been developed for cross-sectional HIV incidence estimation using plasma samples. Large scale surveillance programs are planned using dried blood spot (DBS) specimens for incidence assessment. However, limited information exists on the performance of HIV cross-sectional incidence assays using DBS. METHODS: The assays evaluated were: Maxim HIV-1 Limiting Antigen Avidity EIA (LAg-Avidity), Sedia HIV-1 BED-Capture EIA (BED-CEIA), and CDC modified BioRad HIV-1/2 Plus O Avidity-based Assay (CDC-BioRad Avidity) using pre-determined cutoff values...
2017: PloS One
https://www.readbyqxmd.com/read/28230417/aging-and-half-ironman-performance
#3
M J Stones, Adric Hartin
: Background/Study Context: Previous research on triathlon performance analyzed age trends for the Top Ten or Top Five finishers in world championship or national races at Olympic, Half-Ironman, and Ironman distances. The findings indicated higher age declines and/or earlier onset of decline in swimming and running than cycling. However, the designs of those studies took no account of possible differences between cross-sectional and longitudinal trends (i.e., cohort differences versus age changes)...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28229575/effects-of-a-low-volume-plyometric-training-in-anaerobic-performance-of-adolescent-athletes
#4
Ari R Assunção, Martim Bottaro, Euler A Cardoso, Daiane P Dantas da Silva, Marcelo Ferraz, Carlos A Vieira, Paulo Gentil
BACKGROUND: Parameters related to the anaerobic capacity and power may be important for the performance of many sports whose skills are related to high-intensity and short- duration efforts. Although plyometric training (PT) has been widely used in the regular strength and conditioning programs of young athletes, its effects on anaerobic performance are still controversial. Therefore, the purpose of the present study was to evaluate the effects of PT in anaerobic performance in young athletes...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28229568/yo-yo-ir1-vs-incremental-continuous-running-test-for-prediction-of-3000-m-performance
#5
Boris Schmitz, Andreas Klose, Katrin Schelleckes, Charlotte M Jekat, Michael Krüger, Stefan-Martin Brand
BACKGROUND: This study aimed to compare physiological responses during the Yo-Yo intermittent recovery level 1 (Yo-Yo IR1) test and an incremental continuous running field test (ICRT) and to analyze their predictive value on 3000 m running performance. METHODS: Forty moderately trained individuals (18 females) performed the ICRT and Yo-Yo IR1 test to exhaustion. The ICRT was performed as graded running test with an increase of 2.0 km·h-1 after each 3 min interval for lactate diagnostic...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28228116/examination-of-motor-skill-competency-in-students-evidence-based-physical-education-curriculum
#6
Weiyun Chen, Austin Hammond-Bennett, Andrew Hypnar
BACKGROUND: Researchers found that children with a competent level of motor skill performance are more likely to be physically active. This study examined how well K-1 students demonstrated motor skill competency in relation to Physical Education Content Standard 1. METHODS: Participants were K-1 grade students (N = 1,223-1,588; boys = 568-857; girls = 526-695; Mean age = 5.5 yrs old) who were enrolled in nine elementary schools. The K-1 students' motor skill competency in running, weight transferring, hand dribbling, and underhand catching skills was assessed using four PE Metrics skill assessment rubrics in the intervention year 1 and year 2, respectively...
February 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28228094/sfreemap-a-simulation-free-tool-for-stochastic-mapping
#7
Diego Pasqualin, Marcos Barbeitos, Fabiano Silva
BACKGROUND: Stochastic mapping is frequently used in comparative biology to simulate character evolution, enabling the probabilistic computation of statistics such as number of state transitions along a tree and distribution of states in its internal nodes. Common implementations rely on Continuous-time Markov Chain simulations whose parameters are difficult to adjust and subjected to inherent inaccuracy. Thus, researchers must run a large number of simulations in order to obtain adequate estimates...
February 22, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28227984/preliminary-study-on-the-automated-skull-fracture-detection-in-ct-images-using-black-hat-transform
#8
Ayumi Yamada, Atsushi Teramoto, Tomoko Otsuka, Kohei Kudo, Hirofumi Anno, Hiroshi Fujita, Ayumi Yamada, Atsushi Teramoto, Tomoko Otsuka, Kohei Kudo, Hirofumi Anno, Hiroshi Fujita, Tomoko Otsuka, Hiroshi Fujita, Ayumi Yamada, Kohei Kudo, Hirofumi Anno, Atsushi Teramoto
Linear skull fracture, following head trauma, may reach major blood vessels, such as the middle meningeal artery or sinus venosus, and may cause epidural hematoma. However, hematoma is likely to be missed in the initial interpretation because it spreads only gradually. In addition, the fracture lines that run along the scan slice plane are often missed during initial interpretation. In this study, we develop a novel method for automated detection of the linear skull fracture using head computed tomography (CT) images and conduct a basic evaluation using digital phantom and head phantom that enclose genuine human bones...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227965/multiscale-brain-machine-interface-decoders
#9
Han-Lin Hsieh, Maryam M Shanechi, Han-Lin Hsieh, Maryam M Shanechi, Han-Lin Hsieh, Maryam M Shanechi
Brain-machine interfaces (BMI) have vastly used a single scale of neural activity, e.g., spikes or electrocorticography (ECoG), as their control signal. New technology allows for simultaneous recording of multiple scales of neural activity, from spikes to local field potentials (LFP) and ECoG. These advances introduce the new challenge of modeling and decoding multiple scales of neural activity jointly. Such multi-scale decoding is challenging for two reasons. First, spikes are discrete-valued and ECoG/LFP are continuous-valued, resulting in fundamental differences in statistical characteristics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227893/wearable-embroidered-muscle-activity-sensing-device-for-the-human-upper-leg
#10
R B Ribas Manero, A Shafti, B Michael, J Grewal, J Ll Ribas Fernandez, K Althoefer, M J Howard, R B Ribas Manero, A Shafti, B Michael, J Grewal, J Ll Ribas Fernandez, K Althoefer, M J Howard, K Althoefer, B Michael, A Shafti, J Ll Ribas Fernandez, J Grewal, M J Howard
Within the last decade, running has become one of the most popular physical activities in the world. Although the benefits of running are numerous, there is a risk of Running Related Injuries (RRIs) of the lower extremities. Electromyography (EMG) techniques have previously been used to study causes of RRIs, but the complexity of this technology limits its use to a laboratory setting. As running is primarily an outdoors activity, this lack of technology acts as a barrier to the study of RRIs in natural environments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227763/network-effects-and-pathways-in-deep-brain-stimulation-in-parkinson-s-disease
#11
N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa, N Koirala, V Fleischer, O Granert, G Deuschl, M Muthuraman, S Groppa
Deep brain stimulation of subthalamic nucleus (STN-DBS) became a standard therapeutic option in Parkinson's disease (PD), even though the underlying modulated network of STN-DBS is still poorly described. Probabilistic tractography and connectivity analysis as derived from diffusion tensor imaging (DTI) were performed together with modelling of implanted electrode positions and linked postoperative clinical outcome. Fifteen patients with idiopathic PD without dementia were selected for DBS treatment. After pre-processing, probabilistic tractography was run from cortical and subcortical seeds of the hypothesized network to targets represented by the positions of the active DBS contacts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227694/portable-closed-loop-optogenetic-stimulation-device
#12
Epsy S Edward, Abbas Z Kouzani, Rajas P Kale, Susannah J Tye, Epsy S Edward, Abbas Z Kouzani, Rajas P Kale, Susannah J Tye, Rajas P Kale, Susannah J Tye, Abbas Z Kouzani, Epsy S Edward
This paper presents a closed-loop optogenetic stimulation device to achieve online modulation of neurons. The device is designed to be mountable on small rodents in pre-clinical settings. Considering the size of rodents and the need for portability, a single-piece self-contained device is developed which allows real-time photostimulation based on detected neuronal states. It consists of three components: a neural recorder, a control algorithm, and an optogenetic stimulator. The neural recorder which is realized by analogue circuitry measures the neural signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227683/artsens-%C3%A2-mobile-a-portable-image-free-platform-for-automated-evaluation-of-vascular-stiffness
#13
Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam, Malay Ilesh Shah, Jayaraj Joseph, T Aryasree, Mohanasankar Sivaprakasam, T Aryasree, Mohanasankar Sivaprakasam, Jayaraj Joseph, Malay Ilesh Shah
Vascular stiffness is a key physiological marker significant in screening and early diagnosis of vascular disease. However, state of art techniques for vascular stiffness evaluation are not suited for field deployment. We present ARTSENS(®) Mobile, a portable, image-free ultrasound technology platform for automated evaluation of carotid artery stiffness, amenable for field deployment. The technology utilises a single element ultrasound transducer operated in pulse echo modality to investigate arterial wall dynamics, assisted by intelligent algorithms for wall identification and motion tracking to completely automate the measurement...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227647/a-feasibility-study-of-depth-image-based-intent-recognition-for-lower-limb-prostheses
#14
Huseyin Atakan Varol, Yerzhan Massalin, Huseyin Atakan Varol, Yerzhan Massalin, Huseyin Atakan Varol, Yerzhan Massalin
This paper presents our preliminary work on a depth camera based intent recognition system intended for future use in robotic prosthetic legs. The approach infers the activity mode of the subject for standing, walking, running, stair ascent and stair descent modes only using data from the depth camera. Depth difference images are also used to increase the performance of the approach by discriminating between static and dynamic instances. After confidence map based filtering, simple features such as mean, maximum, minimum and standard deviation are extracted from rectangular regions of the frames...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227608/a-triboelectric-motion-sensor-in-wearable-body-sensor-network-for-human-activity-recognition
#15
Hui Huang, Xian Li, Ye Sun, Hui Huang, Xian Li, Ye Sun, Ye Sun, Hui Huang, Xian Li
The goal of this study is to design a novel triboelectric motion sensor in wearable body sensor network for human activity recognition. Physical activity recognition is widely used in well-being management, medical diagnosis and rehabilitation. Other than traditional accelerometers, we design a novel wearable sensor system based on triboelectrification. The triboelectric motion sensor can be easily attached to human body and collect motion signals caused by physical activities. The experiments are conducted to collect five common activity data: sitting and standing, walking, climbing upstairs, downstairs, and running...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226993/first-steps-to-creating-a-platform-for-high-throughput-simulation-of-ttfields
#16
Hadas Sara Hershkovich, Zeev Bomzon, Cornelia Wenger, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Eilon D Kirson, Uri Weinberg, Yoram Wassermann, Yoram Palti, Hadas Sara Hershkovich, Zeev Bomzon, Cornelia Wenger, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Eilon D Kirson, Uri Weinberg, Yoram Wassermann, Yoram Palti, Yoram Wassermann, Cornelia Wenger, Uri Weinberg, Hadas Sara Hershkovich, Zeev Bomzon, Eilon D Kirson, Dario Garcia-Carracedo, Yoram Palti, Noa Urman, Aafia Chaudhry
Tumor Treating Fields (TTFields) are low intensity alternating electric fields in the 100-500 KHz frequency range that are known to have an anti-mitotic effect on cancerous cells. In the USA, TTFields are approved by the Food and Drug Administration (FDA) for the treatment of glioblastoma (GBM) in both the newly diagnosed and recurrent settings. Optimizing treatment with TTFields requires a deep understanding of how TTFields distribute within the brain. To address this issue, simulations using realistic head models have been performed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226882/development-of-a-real-time-activity-monitoring-android-application-utilizing-smartstep
#17
Nagaraj Hegde, Edward Melanson, Edward Sazonov, Nagaraj Hegde, Edward Melanson, Edward Sazonov, Nagaraj Hegde, Edward Melanson, Edward Sazonov
Footwear based activity monitoring systems are becoming popular in academic research as well as consumer industry segments. In our previous work, we had presented developmental aspects of an insole based activity and gait monitoring system-SmartStep, which is a socially acceptable, fully wireless and versatile insole. The present work describes the development of an Android application that captures the SmartStep data wirelessly over Bluetooth Low energy (BLE), computes features on the received data, runs activity classification algorithms and provides real time feedback...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226793/a-comparative-study-of-pseudorandom-sequences-used-in-a-c-vep-based-bci-for-online-wheelchair-control
#18
Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady, Jonas Isaksen, Ali Mohebbi, Sadasivan Puthusserypady, Jonas Isaksen, Sadasivan Puthusserypady, Ali Mohebbi
In this study, a c-VEP based BCI system was developed to run on three distinctive pseudorandom sequences, namely the m-code, the Gold-code, and the Barker-code. The Visual Evoked Potentials (VEPs) were provoked using these codes. In the online session, subjects controlled a LEGO(®) Mindstorms(®) robot around a fixed track. Choosing the optimal code proved a significant increase in accuracy (p<;0.00001) over the average performance. No single code proved significantly more accurate than the others (p=0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226733/association-between-tumor-heterogeneity-and-progression-free-survival-in-non-small-cell-lung-cancer-patients-with-egfr-mutations-undergoing-tyrosine-kinase-inhibitors-therapy
#19
Jiangdian Song, Di Dong, Yanqi Huang, Yali Zang, Zaiyi Liu, Jie Tian, Jiangdian Song, Di Dong, Yanqi Huang, Yali Zang, Zaiyi Liu, Jie Tian, Zaiyi Liu, Yanqi Huang, Yali Zang, Jiangdian Song, Jie Tian, Di Dong
For non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations, current staging methods do not accurately predict the risk of disease recurrence after tyrosine kinase inhibitors (TKI) therapy. Developing a noninvasive method to predict whether individual could benefit from TKI therapy has great clinical significance. In this research, a radiomics approach was proposed to determine whether the tumor heterogeneity of NSCLC, which was measured by the texture on computed tomography (CT), could make an independent prediction of progression-free survival (PFS)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225523/the-age-related-performance-decline-in-ironman-triathlon-starts-earlier-in-swimming-than-in-cycling-and-running
#20
Ilja Käch, Christoph A Rüst, Pantelis T Nikolaidis, Thomas Rosemann, Beat Knechtle
In Ironman triathlon, the number of overall male and female finishers increased in the last 30 years, while an improvement in performance has been reported. Studies concluding these numbers only analysed the top ten athletes per age group instead of all finishers, therefore a selection bias might have occurred. The aim of the present study was to investigate participation, performance and the age-related performance decline of all pro and age group triathletes ranked in all Ironman triathlons held worldwide between 2002 and 2015...
February 21, 2017: Journal of Strength and Conditioning Research
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