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https://www.readbyqxmd.com/read/29342232/informational-and-linguistic-analysis-of-large-genomic-sequence-collections-via-efficient-hadoop-cluster-algorithms
#1
Umberto Ferraro Petrillo, Gianluca Roscigno, Giuseppe Cattaneo, Raffaele Giancarlo
Motivation: Information theoretic and compositional/linguistic analysis of genomes have a central role in bioinformatics, even more so since the associated methodologies are becoming very valuable also for epigenomic and meta-genomic studies. The kernel of those methods is based on the collection of k-mer statistics, i.e., how many times each k-mer in {A;C; G; T}k occurs in a DNA sequence. Although this problem is computationally very simple and efficiently solvable on a conventional computer, the sheer amount of data available now in applications demands to resort to parallel and distributed computing...
January 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29342146/a-theory-of-how-active-behavior-stabilises-neural-activity-neural-gain-modulation-by-closed-loop-environmental-feedback
#2
Christopher L Buckley, Taro Toyoizumi
During active behaviours like running, swimming, whisking or sniffing, motor actions shape sensory input and sensory percepts guide future motor commands. Ongoing cycles of sensory and motor processing constitute a closed-loop feedback system which is central to motor control and, it has been argued, for perceptual processes. This closed-loop feedback is mediated by brainwide neural circuits but how the presence of feedback signals impacts on the dynamics and function of neurons is not well understood. Here we present a simple theory suggesting that closed-loop feedback between the brain/body/environment can modulate neural gain and, consequently, change endogenous neural fluctuations and responses to sensory input...
January 17, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29341325/characterization-of-adrenal-lesions-on-unenhanced-mri-using-texture-analysis-a-machine-learning-approach
#3
Valeria Romeo, Simone Maurea, Renato Cuocolo, Mario Petretta, Pier Paolo Mainenti, Francesco Verde, Milena Coppola, Serena Dell'Aversana, Arturo Brunetti
BACKGROUND: Adrenal adenomas (AA) are the most common benign adrenal lesions, often characterized based on intralesional fat content as either lipid-rich (LRA) or lipid-poor (LPA). The differentiation of AA, particularly LPA, from nonadenoma adrenal lesions (NAL) may be challenging. Texture analysis (TA) can extract quantitative parameters from MR images. Machine learning is a technique for recognizing patterns that can be applied to medical images by identifying the best combination of TA features to create a predictive model for the diagnosis of interest...
January 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29340550/modified-heidelberg-technique-for-pancreatic-anastomosis
#4
Orlando Jorge M Torres, Roberto C N da Cunha Costa, Felipe F Macatrão Costa, Romerito Fonseca Neiva, Tarik Soares Suleiman, Yglésio L Moyses S Souza, Shailesh V Shrikhande
BACKGROUND: Pancreatic fistula is a major cause of morbidity and mortality after pancreatoduodenectomy. To prevent this complication, many technical procedures have been described. AIM: To present a novel technique based on slight modifications of the original Heidelberg technique, as new pancreatojejunostomy technique for reconstruction of pancreatic stump after pancreatoduodenectomy and present initial results. METHOD: The technique was used for patients with soft or hard pancreas and with duct size smaller or larger than 3 mm...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29340527/cardiac-protein-expression-patterns-are-associated-with-distinct-inborn-exercise-capacity-in-non-selectively-bred-rats
#5
L P Ribeiro, L C Freitas-Lima, G B Naumann, S S Meyrelles, W Lunz, S F Pires, H M Andrade, J B T Carnielli, S G Figueiredo
In the present study, we successfully demonstrated for the first time the existence of cardiac proteomic differences between non-selectively bred rats with distinct intrinsic exercise capacities. A proteomic approach based on two-dimensional gel electrophoresis coupled to mass spectrometry was used to study the left ventricle (LV) tissue proteome of rats with distinct intrinsic exercise capacity. Low running performance (LRP) and high running performance (HRP) rats were categorized by a treadmill exercise test, according to distance run to exhaustion...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29340299/prospective-study-of-the-feasibility-of-point-of-care-testing-strategy-for-carbapenem-resistant-organism-detection
#6
Rahul Pannala, Bruce Baldwin, Vijay Aluru, Thomas E Grys, Jordan Holmes, Laurence J Miller, M Edwyn Harrison, Cuong C Nguyen, Fred C Tenover, David Persing, Douglas O Faigel
Background/aims:  In an investigator-initiated, prospective study, we evaluated the feasibility of a five-gene sequence point-of-care (POC) testing strategy (Xpert CARBA-R Assay, Cepheid Inc., Sunnyvale, CA, USA), compared to reference laboratory PCR (48 - 72 hours turnaround time, two gene sequences), in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and in a hospital outbreak investigation. Methods:  After informed consent, patients undergoing ERCP (September 2015 - April 2016, n = 191) at Mayo Clinic and potential hospital contacts (n = 9) of an index carbapenem-resistant organism (CRO)-positive inpatient were included...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29340161/direct-ice-imaging-from-inside-the-left-atrial-appendage-during-ablation-of-persistent-atrial-fibrillation
#7
Gabriel Cismaru, Mihai Puiu, Radu Rosu, Lucian Muresan, Gabriel Gusetu, Dana Pop, Dumitru Zdrenghea
We present the case of a 59-year-old patient with persistent atrial fibrillation, referred for atrial fibrillation ablation. The procedure was performed with the help of NAVX 3D mapping system (Saint Jude Medical) and iLAB Ultra ICE Plus ultrasound imaging catheter (Boston Scientific). The catheter permits cross-sectional images perpendicular to catheter's long axis. From inside left atrial appendage (LAA) looks trabeculated, due to pectinate muscles running parallel to each other. The presence of a thrombus was excluded from the appendage...
January 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29339999/reliability-and-usefulness-of-the-30-15-intermittent-fitness-test-in-male-and-female-professional-futsal-players
#8
Santiago Valladares-Rodríguez, Ezequiel Rey, Marcos Mecías-Calvo, Roberto Barcala-Furelos, Antonio J Bores-Cerezal
The purpose of this study was to determine the reliability and usefulness of the 30-15 Intermittent Fitness Test (30-15IFT) in professional male and female futsal players. Thirteen male (24.4 ± 5.6 years; 174.5 ± 10.3 cm; 70.3 ± 9.9 kg) and fourteen female (23.3 ± 4.5 years; 165.8 ± 6.2 cm; 61.7 ± 5.5 kg) professional futsal players performed the 30-15IFT on two occasions, separated by 5 days. Maximal intermittent running velocity (VIFT) and heart rate at exhaustion (HRpeak) data were collected for both tests...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339992/effects-of-passive-and-active-rest-on-physiological-responses-and-time-motion-characteristics-in-different-small-sided-soccer-games
#9
Ersan Arslan, Utku Alemdaroglu, Yusuf Koklu, Tahir Hazir, Surhat Muniroglu, Baris Karakoc
The purpose of this study was to investigate the effects of resting regimes on physiological responses and time motion characteristics between bouts during small sided games (SSGs) in young soccer players. Sixteen players (average age 16.87 ± 0.34 years; body height 176.69 ± 3.21 cm; body mass 62.40 ± 2.59 kg; training experience 3.75 ± 0.44 years) performed four bouts 2-a-side, 3-a-side and 4-a-side games with three minutes active (SSGar: Running at 70% of HRmax) and passive (SSGpr) rest between bouts at two-day intervals...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339991/multivariate-profiles-of-selected-versus-non-selected-elite-youth-brazilian-soccer-players
#10
Rodrigo Aquino, Isabella S Alves, Maickel B Padilha, Filipe Casanova, Enrico F Puggina, José Maia
This study determined whether a multivariate profile more effectively discriminated selected than non-selected elite youth Brazilian soccer players. This examination was carried out on 66 youth soccer players (selected, n = 28, mean age 16.3 ± 0.1; non-selected, n = 38, mean age 16.7 ± 0.4) using objective instruments. Multivariate profiles were assessed through anthropometric characteristics, biological maturation, tactical-technical skills, and motor performance. The Student's t-test identified that selected players exhibited significantly higher values for height (t = 2...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339931/assessment-of-knowledge-and-skills-in-information-literacy-instruction-for-rehabilitation-sciences-students-a-scoping-review
#11
Jill T Boruff, Pamela Harrison
Objective: This scoping review investigates how knowledge and skills are assessed in the information literacy (IL) instruction for students in physical therapy, occupational therapy, or speech-language pathology, regardless of whether the instruction was given by a librarian. The objectives were to discover what assessment measures were used, determine whether these assessment methods were tested for reliability and validity, and provide librarians with guidance on assessment methods to use in their instruction in evidence-based practice contexts...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29338304/investigation-of-the-use-of-external-aluminum-targets-for-portal-imaging-in-a-medical-accelerator-using-geant4-monte-carlo-simulation
#12
Hyungdong Kim, Byungyong Kim, Jonggeun Baek, Youngkee Oh, Hyunsoo Jang
OBJECTIVE: To install a low-Z target on the wedge tray mount of a medical linear accelerator to create a new image beam and to confirm image contrast enhancement. METHODS: Experimental low-energy photon beams were produced with the linac running in the 6 MeV electron mode and with a low-Z target installed on the wedge tray mount (denoted 6 MeV (low-Z target)). Geant4 Monte Carlo simulation (MCS) was performed to analyze the energy spectrum and image contrast of a 6 MeV (low-Z target) beam...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29338013/dynamical-networks-of-influence-in-small-group-discussions
#13
Mehdi Moussaïd, Alejandro Noriega Campero, Abdullah Almaatouq
In many domains of life, business and management, numerous problems are addressed by small groups of individuals engaged in face-to-face discussions. While research in social psychology has a long history of studying the determinants of small group performances, the internal dynamics that govern a group discussion are not yet well understood. Here, we rely on computational methods based on network analyses and opinion dynamics to describe how individuals influence each other during a group discussion. We consider the situation in which a small group of three individuals engages in a discussion to solve an estimation task...
2018: PloS One
https://www.readbyqxmd.com/read/29337832/comparison-of-step-by-step-kinematics-in-repeated-30m-sprints-in-female-soccer-players
#14
Roland van den Tillaar
The aim of this study was to compare kinematics in repeated 30m sprints in female soccer players. Seventeen subjects performed seven 30m sprints every 30s in one session. Kinematics were measured with an infrared contact mat and laser gun, and running times with an electronic timing device. The main findings were that sprint times increased in the repeated sprint ability test. The main changes in kinematics during the repeated sprint ability test were increased contact time and decreased step frequency, while no change in step length was observed...
January 4, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29337419/evolution-of-resistance-to-chytridiomycosis-is-associated-with-a-robust-early-immune-response
#15
Laura F Grogan, Scott D Cashins, Lee F Skerratt, Lee Berger, Michael S McFadden, Peter Harlow, David A Hunter, Ben C Scheele, Jason Mulvenna
Potentiating the evolution of immunity is a promising strategy for addressing biodiversity diseases. Assisted selection for infection resistance may enable the recovery and persistence of amphibians threatened by chytridiomycosis; a devastating fungal skin disease threatening hundreds of species globally. However, knowledge of the mechanisms involved in the natural evolution of immunity to chytridiomycosis is limited. Understanding the mechanisms of such resistance may help speed assisted-selection. Using a transcriptomics approach we examined gene expression responses of endangered alpine tree frogs (Litoria verreauxii alpina) to subclinical infection, comparing two long-exposed populations with a naïve population...
January 16, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29336211/the-effect-of-altering-loading-distance-on-skeleton-start-performance-is-higher-pre-load-velocity-always-beneficial
#16
Steffi L Colyer, Keith A Stokes, James L J Bilzon, Danny Holdcroft, Aki I T Salo
Athletes initiating skeleton runs differ in the number of steps taken before loading the sled. We aimed to understand how experimentally modifying loading distance influenced sled velocity and overall start performance. Ten athletes (five elite, five talent; 67% of all national athletes) underwent two to four sessions, consisting of two dry-land push-starts in each of three conditions (preferred, long and short loading distances). A magnet encoder on the sled wheel provided velocity profiles and the overall performance measure (sled acceleration index)...
January 16, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29336181/analytical-and-between-subject-variation-of-thrombin-generation-measured-by-calibrated-automated-thrombography-on-plasma-samples
#17
Anne F Kristensen, Søren R Kristensen, Ursula Falkmer, Anna-Marie B Münster, Shona Pedersen
BACKGROUND: The Calibrated Automated Thrombography (CAT) is an in vitro thrombin generation (TG) assay that holds promise as a valuable tool within clinical diagnostics. However, the technique has a considerable analytical variation, and we therefore, investigated the analytical and between-subject variation of CAT systematically. Moreover, we assess the application of an internal standard for normalization to diminish variation. METHODS: 20 healthy volunteers donated one blood sample which was subsequently centrifuged, aliquoted and stored at -80 °C prior to analysis...
January 16, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29335575/genotypic-variability-enhances-the-reproducibility-of-an-ecological-study
#18
Alexandru Milcu, Ruben Puga-Freitas, Aaron M Ellison, Manuel Blouin, Stefan Scheu, Grégoire T Freschet, Laura Rose, Sebastien Barot, Simone Cesarz, Nico Eisenhauer, Thomas Girin, Davide Assandri, Michael Bonkowski, Nina Buchmann, Olaf Butenschoen, Sebastien Devidal, Gerd Gleixner, Arthur Gessler, Agnès Gigon, Anna Greiner, Carlo Grignani, Amandine Hansart, Zachary Kayler, Markus Lange, Jean-Christophe Lata, Jean-François Le Galliard, Martin Lukac, Neringa Mannerheim, Marina E H Müller, Anne Pando, Paula Rotter, Michael Scherer-Lorenzen, Rahme Seyhun, Katherine Urban-Mead, Alexandra Weigelt, Laura Zavattaro, Jacques Roy
Many scientific disciplines are currently experiencing a 'reproducibility crisis' because numerous scientific findings cannot be repeated consistently. A novel but controversial hypothesis postulates that stringent levels of environmental and biotic standardization in experimental studies reduce reproducibility by amplifying the impacts of laboratory-specific environmental factors not accounted for in study designs. A corollary to this hypothesis is that a deliberate introduction of controlled systematic variability (CSV) in experimental designs may lead to increased reproducibility...
January 15, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29335504/testing-for-the-presence-of-correlation-changes-in-a-multivariate-time-series-a-permutation-based-approach
#19
Jedelyn Cabrieto, Francis Tuerlinckx, Peter Kuppens, Borbála Hunyadi, Eva Ceulemans
Detecting abrupt correlation changes in multivariate time series is crucial in many application fields such as signal processing, functional neuroimaging, climate studies, and financial analysis. To detect such changes, several promising correlation change tests exist, but they may suffer from severe loss of power when there is actually more than one change point underlying the data. To deal with this drawback, we propose a permutation based significance test for Kernel Change Point (KCP) detection on the running correlations...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334675/effects-of-running-retraining-on-biomechanical-factors-associated-with-lower-limb-injury
#20
Marcus D Dunn, David B Claxton, Graham Fletcher, Jonathan S Wheat, David M Binney
Injury risk is an important concern for runners; however, limited evidence exists regarding changes to injury risk following running style retraining. Biomechanical factors, such as absolute peak free moment, knee abduction impulse, peak foot eversion and foot eversion excursion, have been shown to predict lower limb injury. The aim of this study was to assess the effects of Pose running retraining on biomechanical factors associated with lower limb running injury. Twenty uninjured recreational runners were pair-matched based on their five km run time performance and randomly assigned to control (n = 10) and intervention (three 2-h Pose running retraining sessions) groups (n = 10)...
January 12, 2018: Human Movement Science
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