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https://www.readbyqxmd.com/read/29671537/chronic-pancreatitis-diagnosis-and-treatment
#1
Kathleen Barry
Chronic pancreatitis is an irreversible and progressive disorder of the pancreas characterized by inflammation, fibrosis, and scarring. Exocrine and endocrine functions are lost, often leading to chronic pain. The etiology is multifactorial, although alcoholism is the most significant risk factor in adults. The average age at diagnosis is 35 to 55 years. If chronic pancreatitis is suspected, contrast-enhanced computed tomography is the best imaging modality for diagnosis. Computed tomography may be inconclusive in early stages of the disease, so other modalities such as magnetic resonance imaging, magnetic resonance cholangiopancreatography, or endoscopic ultrasonography with or without biopsy may be used...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29662703/aortic-dissection-presenting-as-acute-pancreatitis-suspecting-the-unexpected
#2
Adam Hafeez, Dillon Karmo, Adrian Mercado-Alamo, Alexandra Halalau
Aortic dissection is a life-threatening condition in which the inner layer of the aorta tears. Blood surges through the tear, causing the inner and middle layers of the aorta to separate (dissect). It is considered a medical emergency. We report a case of a healthy 56-year-old male who presented to the emergency room with sudden onset of epigastric pain radiating to his back. His blood pressure was 167/91 mmHg, equal in both arms. His lipase was elevated at 1258 U/L, and he was clinically diagnosed with acute pancreatitis (AP)...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29662231/processed-meat-and-risk-of-selected-digestive-tract-and-laryngeal-cancers
#3
Valentina Rosato, Daisuke Kawakita, Eva Negri, Diego Serraino, Werner Garavello, Maurizio Montella, Adriano Decarli, Carlo La Vecchia, Monica Ferraroni
BACKGROUND/OBJECTIVES: To assess the association between processed meat and the risk of selected digestive tract and laryngeal cancers. SUBJECTS/METHODS: We conducted a series of case-control studies between 1985 and 2007 in Italy. The studies included a total of 1475 cases of cancer of the oral cavity and pharynx, 1077 of the larynx, 716 of the esophagus, 999 of the stomach, 684 of the liver, 159 of the biliary tract, 688 of the pancreas, and a total of 9720 controls...
April 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29660323/nationwide-trends-in-acute-and-chronic-pancreatitis-among-privately-insured-children-and-non-elderly-adults-in-the-united-states-2007-2014
#4
Zachary M Sellers, Donna MacIsaac, Helen Yu, Melody Dehghan, Ke-You Zhang, Rachel Bensen, Jessie J Wong, Cindy Kin, K T Park
BACKGROUND & AIMS: Epidemiologic analyses of acute and chronic pancreatitis (AP and CP) provide insight into causes and strategies for prevention, and affect allocation of resources to its study and treatment. We sought to determine current and accurate incidences of AP and CP, along with the prevalence of CP, in children and adults in the United States. METHODS: We collected data from the Truven MarketScan Research Databases of commercial inpatient and outpatient insurance claims in the United States from 2007 through 2014 (patients 0-64 years old)...
April 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29643268/proposed-cut-off-value-of-ca19-9-for-detecting-pancreatic-cancer-in-patients-with-diabetes-a-case-control-study
#5
Mariko Murakami, Yoshio Nagai, Ayumi Tenjin, Yasushi Tanaka
Pancreatic cancer is a highly lethal malignancy. CA19-9 is a well-known marker for diagnosis of pancreatic cancer, but the serum CA19-9 level is reported to be elevated in patients with poorly controlled diabetes. This study evaluated the sensitivity, specificity, and cut-off value of serum CA19-9 for detection of pancreatic cancer in patients with diabetes. A case-control study of 236 patients was performed. The case group was selected from diabetic patients with pancreatic cancer, while one control was selected for each case from among diabetic patients without pancreatic cancer during the same period...
April 11, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29642943/celiac-axis-stenosis-due-to-median-arcuate-ligament-compression-in-a-patient-who-underwent-pancreatoduodenectomy-intraoperative-assessment-of-hepatic-arterial-flow-using-doppler-ultrasonography-a-case-report
#6
Masateru Yamamoto, Toshiyuki Itamoto, Akihiko Oshita, Yasuhiro Matsugu
BACKGROUND: Celiac axis stenosis due to compression by the median arcuate ligament has been reported in patients undergoing pancreaticoduodenectomy; it leads to the development of major collateral pathways that feed the hepatic artery. Dividing these important collaterals during pancreaticoduodenectomy can cause ischemic complications which may lead to a high mortality rate. To prevent these complications, it is necessary to assess intrahepatic arterial flow. CASE PRESENTATION: A 71-year-old Japanese man with anorexia was referred to us for the treatment of alcoholic chronic pancreatitis...
April 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29629907/incidence-admission-rates-and-predictors-and-economic-burden-of-adult-emergency-visits-for-acute-pancreatitis-data-from-the-national-emergency-department-sample-2006-to-2012
#7
Sushil K Garg, Shashank Sarvepalli, James P Campbell, Itegbemie Obaitan, Dupinder Singh, Fateh Bazerbachi, Rajeshwar Singh, Madhusudhan R Sanaka
INTRODUCTION: Acute pancreatitis (AP) is the most common gastroenterology-related reason for hospital admission, and a major source of morbidity and mortality in the United States. This study examines the National Emergency Database Sample, a large national database, to analyze trends in emergency department (ED) utilization and costs, risk factors for hospital admission, and associated hospital costs and length of stay (LOS) in patients presenting with AP. METHODS: The National Emergency Database Sample (2006 to 2012) was evaluated for trends in ED visits, ED charges, hospitalization rates, hospital charges, and hospital LOS in patients with primary diagnosis of AP (further subcategorized by age and etiology)...
April 6, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29618573/the-risk-of-acute-pancreatitis-after-initiation-of-dipeptidyl-peptidase-4-inhibitors-testing-a-hypothesis-of-subgroup-differences-in-older-u-s-adults
#8
Jin-Liern Hong, John B Buse, Michele Jonsson Funk, Virginia Pate, Til Stürmer
OBJECTIVE: To examine whether dipeptidyl peptidase 4 inhibitors (DPP-4I) increase acute pancreatitis risk in older patients and whether the association varies by age, sex, and history of cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS: We conducted a cohort study of DPP-4I initiators versus thiazolidinedione (TZD) or sulfonylurea initiators using U.S. Medicare beneficiaries, 2007-2014. Eligible initiators were aged 66+ years without history of pancreatic disease or alcohol-related diseases...
April 4, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29595342/lifetime-alcohol-intake-and-pattern-of-alcohol-consumption-in-patients-with-alcohol-induced-pancreatitis-in-comparison-with-patients-with-alcohol-use-disorder
#9
Jon Juliusson Sigurdur, Jon Kristinn Nielsen, Valgerdur Runarsdottir, Ingunn Hansdottir, Ragna Sigurdardottir, Einar S Björnsson
OBJECTIVE: To examine lifetime drinking patterns in men and women with alcohol-induced pancreatitis (AIP) in comparison with patients with alcoholic use disorder (AUD) without pancreatic disease. METHODS: Alcohol consumption patterns were assessed using a validated questionnaire, the Lifetime Drinking History (LDH), during an outpatient visit. Patients diagnosed with AIP were matched for gender and age (+/- 5 years) with patients with AUD in addiction treatment...
March 29, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29595117/non-alcoholic-fatty-pancreas-disease-nafpd-a-silent-spectator-or-the-fifth-component-of-metabolic-syndrome-a-literature-review
#10
Bhupinder Romana, Harleen Chela, Francis Dailey, Fatiha Nassir, Veysel Tahan
Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1933. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29594198/hepatic-infarction-and-acute-pancreatitis-a-case-report-and-review-of-the-literature
#11
Archana Kulkarni, Hamza Arif, Manik Veer, Kateyln Ziggas, Amit Kaura, Meera Sareen
Hepatic infarction is rare due to the unique dual hepatic blood supply from the hepatic artery and the portal vein. Herein, we report a case of hepatic infarction that occurred as a complication of acute pancreatitis. The patient was a 58-year-old male with past medical history of chronic alcoholism, who presented with epigastric abdominal pain, nausea, and vomiting. Hepatic infarction was diagnosed with computed tomography of the abdomen and pelvis without contrast, which revealed suspicion of splenic vein thrombosis and peripancreatic fat stranding along with a wedge-shaped, peripheral hypo density in the right hepatic lobe with typical morphology for hepatic infarction...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29575044/correlation-between-neutrophil-lymphocyte-ratio-and-ranson-score-in-acute-pancreatitis
#12
Bahri Abaylı, Genco Gençdal, Şerife Değirmencioğlu
BACKGROUND: Acute pancreatitis (AP) is characterized by inflammation of the pancreas, elevated pancreatic enzymes, and abdominal pain. The neutrophil to lymphocyte ratio (NLR) is used as a marker of inflammation. In this retrospective study, we aimed to investigate novel early prognostic predictors of AP, such as NLR and its correlation with the Ranson score. METHODS: A total 435 patients (Male: 152; 34.9%, Age: 63.53 ± 17.22 years) were included in the study...
March 24, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29572825/new-onset-non-alcoholic-fatty-liver-disease-after-resection-of-pancreatic-neuroendocrine-tumors
#13
Tara Michella Mackay, Cansu Güney Genç, Robert Bart Takkenberg, Marc Gerard Besselink, Inne Somers, Elisabeth Jacqueline Maria Nieveen van Dijkum
BACKGROUND AND OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatis (NASH) may occur after pancreatic resection due to exocrine pancreatic insufficiency (EPI). Patients with long-term survival, such as after pancreatic neuroendocrine tumor (pNET) resection, are at risk of NAFLD/NASH. We aimed to determine the incidence and risk factors for new onset NAFLD/NASH and EPI after pNET resection. METHODS: Retrospective monocenter cohort study...
March 24, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29566476/predictors-of-malignancies-in-patients-with-inconclusive-or-negative-results-of-endoscopic-ultrasound-guided-fine-needle-aspiration-for-solid-pancreatic-masses
#14
Hyewon Jeong, Chan Sun Park, Ki Bae Kim, Joung Ho Han, Soon Man Yoon, Hee Bok Chae, Sei Jin Youn, Seon Mee Park
Background/Aims: This study analyzed the diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for pancreatic solid masses in patients with or without chronic pancreatitis as well as the clinical parameters relevant to a malignancy when EUS-FNA was negative or inconclusive. Methods: A total of 97 patients, who underwent EUS-FNA for solid pancreatic masses over 2 years at a single institution, were evaluated. All patients underwent EUS-FNA for 3-5 passes with 22 or 25 G needles without an on-site cytopathologist...
March 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29560600/prevalence-of-cardiovascular-dysfunction-and-its-association-with-outcome-in-patients-with-acute-pancreatitis
#15
Raghavendra Prasada, Narendra Dhaka, Ajay Bahl, Thakur Deen Yadav, Rakesh Kochhar
BACKGROUND: Organ failure (OF) is the most important predictor of outcome in severe acute pancreatitis (SAP). Cardiovascular failure (CVSF) occurs in a variable proportion of patients with SAP. We aimed to study myocardial dysfunction in acute pancreatitis (AP) and its impact on the outcome. METHODS: In this prospective study between January 2011 and July 2012, consecutive eligible patients of AP were enrolled. Myocardial function was assessed by measuring CK-MB (creatine phosphokinase isoenzyme) and echocardiography at admission...
March 21, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29555983/characterization-of-intestinal-microbiota-in-alcoholic-patients-with-and-without-alcoholic-hepatitis-or-chronic-alcoholic-pancreatitis
#16
Dragos Ciocan, Vinciane Rebours, Cosmin Sebastian Voican, Laura Wrzosek, Virginie Puchois, Anne-Marie Cassard, Gabriel Perlemuter
Excessive alcohol consumption leads to severe alcoholic hepatitis (sAH) or chronic alcoholic pancreatitis (CAP) only in a subset of patients. We aimed to characterize the intestinal microbiota profiles of alcoholic patients according to the presence and nature of the complications observed: sAH or CAP. Eighty two alcoholic patients were included according to their complications: CAP (N = 24), sAH (N = 13) or no complications (alcoholic controls, AC, N = 45). We analyzed the intestinal microbiota by high-throughput sequencing...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29524225/lifetime-and-baseline-alcohol-intakes-and-risk-of-pancreatic-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-study
#17
Sabine Naudin, Kuanrong Li, Tristan Jaouen, Nada Assi, Cecilie Kyrø, Anne Tjønneland, Kim Overvad, Marie-Christine Boutron-Ruault, Vinciane Rebours, Anne-Laure Védié, Heiner Boeing, Rudolf Kaaks, Verena Katzke, Christina Bamia, Androniki Naska, Antonia Trichopoulou, Franco Berrino, Giovanna Tagliabue, Domenico Palli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Petra H Peeters, Bas Bueno-de-Mesquita, Elisabete Weiderpass Vainio, Inger Torhild Gram, Guri Skeie, Maria-Dolores Chirlaque, Miguel Rodríguez-Barranco, Aurelio Barricarte, Jose Ramón Quirós, Miren Dorronsoro, Ingegerd Johansson, Malin Sund, Hanna Sternby, Kathryn E Bradbury, Nick Wareham, Elio Riboli, Marc Gunter, Paul Brennan, Eric J Duell, Pietro Ferrari
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In this study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively...
March 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29523291/ercp-induced-and-non-ercp-induced-acute-pancreatitis-two-distinct-clinical-entities
#18
Ivana Zitinic, Ivana Plavsic, Goran Poropat, Goran Hauser
Acute pancreatitis (AP) is a common gastrointestinal disease of varied etiology; however, the most common causes of AP are gallstones and alcohol abuse. AP has emerged as the most frequent complication after endoscopic retrograde cholangiopancreatography (ERCP). Post-ERCP pancreatitis is generally a clinically irrelevant condition; however, it can be severe or even fatal in up to 0.8% of cases. Different clinical courses and outcomes have been observed between mild and severe AP of different etiologies (i.e...
April 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29522553/association-between-chronic-pancreatitis-and-urolithiasis-a-population-based-cohort-study
#19
Chien-Hua Chen, Cheng-Li Lin, Long-Bin Jeng
PURPOSE: Chronic pancreatitis (CP) can cause fat or bile acid malabsorption due to exocrine insufficiency. Fat or bile acid malabsorption has been reported to increase the risk of urolithiasis through increased intestinal oxalate absorption. However, no studies have reported an association between CP and urolithiasis. METHODS: We identified 15,848 patients (age: ≥20 years) diagnosed as having CP between 2000 and 2010 from the National Health Insurance Research Database as the study cohort...
2018: PloS One
https://www.readbyqxmd.com/read/29521066/new-predictor-of-acute-necrotizing-pancreatitis-red-cell-distribution-width
#20
Mehmet Suat Yalçın, Adnan Tas, Banu Kara, Sehmus Olmez, Bunyamin Saritas
BACKGROUND: Acute pancreatitis (AP) is inflammation of the pancreas of various severity ranging from mild abdominal pain to mortality. AP may be classified as acute interstitial edematous pancreatitis (AEP) or acute necrotizing pancreatitis (ANP), according to the revised Atlanta criteria. Most of the patients with AP are AEP (75-85% of patients), while 15-25% of patients have ANP. The mortality rate is 3% in AEP and 15% in ANP. Thus, it is important to predict the severity of AP to decrease the morbidity and mortality...
February 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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