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alcoholic pancreatitis

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https://www.readbyqxmd.com/read/29231795/quantification-of-parenchymal-calcifications-in-chronic-pancreatitis-relation-to-atrophy-ductal-changes-fibrosis-and-clinical-parameters
#1
Pernille Lykke Andersen, Adnan Madzak, Søren Schou Olesen, Asbjørn Mohr Drewes, Jens Brøndum Frøkjaer
OBJECTIVES: Parenchymal calcifications are considered a hallmark finding of chronic pancreatitis (CP), but little is known about its relation to the clinical presentation and other morphological features such as atrophy, fibrosis and ductal changes. The aim was to quantify the number and maximal size of parenchymal calcifications assessed on computed tomography (CT) and to explore the association with other CT and magnetic resonance imaging (MRI)-based pancreatic features and clinical parameters...
December 12, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29222221/acute-pancreatitis-following-oesophagogastroduodenoscopy
#2
Nnamdi Arinze Nwafo
Acute pancreatitis is a well-recognised complication of endoscopic procedures like endoscopic retrograde cholangiopancreatography but not oesophagogastroduodenoscopy (OGD). I report a case of a 33-year-old woman, admitted with severe epigastric pain and vomiting 2 hours after an elective OGD for evaluation of chronic gastrointestinal symptoms. Pancreatitis was diagnosed on the basis of elevated lipase (40 790 U/L; normal 11-82) and findings on imaging studies. Other common causes of acute pancreatitis such as gallstones, alcohol and medications were ruled out...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29221631/a-population-based-evaluation-of-the-natural-history-of-chronic-pancreatitis
#3
Jorge D Machicado, Suresh T Chari, Lawrence Timmons, Gong Tang, Dhiraj Yadav
BACKGROUND: Based on reports from tertiary care centers, chronic pancreatitis (CP) is considered to be a painful and debilitating disease frequently requiring invasive interventions. Our primary aim was to assess the natural course of CP in a population-based cohort using endoscopic and surgical interventions as surrogates for disease aggressiveness. METHODS: We identified all patients (n = 89, alcoholic [ACP = 46], non-alcoholic [NACP] = 43) with newly diagnosed definite CP from Olmsted County, Minnesota between 1977 and 2006...
November 24, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29217908/a-novel-method-for-pain-relief-in-chronic-pancreatitis-an-old-drug-in-a-new-pack-a-controlled-study
#4
Aswini Kumar Pujahari
Most of pain-relieving agents in chronic pancreatitis are nonspecific and unpredictable. Omeprazole induces hypergastrinemia due to reduced gastric acidity. Raised serum gastrin, in turn, modulates to reduce secretin level. Secretin is responsible for secretion of almost 80 % bicarbonate-rich pancreatic juice from the ductular epithelium without affecting enzyme output. It is a prospective randomized study in patients with CT-confirmed chronic pancreatitis. The control group got the standard care and 60 mg of omeprazole twice daily was added to the test group...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29209119/how-severe-is-moderately-severe-acute-pancreatitis-clinical-validation-of-revised-2012-atlanta-classification
#5
Povilas Ignatavicius, Aiste Gulla, Karolis Cernauskis, Giedrius Barauskas, Zilvinas Dambrauskas
AIM: To explore the outcomes and the appropriate treatment for patients with moderately severe acute pancreatitis (AP). METHODS: Statistical analysis was performed on data from the prospectively collected database of 103 AP patients admitted to the Department of Surgery, Hospital of Lithuanian University of Health Sciences in 2008-2013. All patients were confirmed to have the diagnosis of AP during the first 24 h following admission. The severity of pancreatitis was assessed by MODS and APACHE II scale...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29207780/autoimmune-pancreatitis-type-ii-first-report-from-india
#6
Gunjan Desai, Prasad Pande, Chandralekha Tampi, Prasad Wagle
Autoimmune Pancreatitis (AIP) presents in two forms - Type I or lymphoplasmacytic sclerosing pancreatitis and Type II or idiopathic ducto-centric pancreatitis (IDCP). AIP II is rare in south Asia and, especially so, in India. Most patients have either Idiopathic Chronic Pancreatitis (ICP) or alcohol related chronic pancreatitis. AIP Type I has been described in India. We herein report a patient who had features of ICP on imaging, for whom surgery was performed to relieve chronic pancreatic pain. However, the pathologic features revealed AIP Type II or IDCP...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206674/long-term-outcome-and-causes-of-death-for-working-age-patients-hospitalized-due-to-acute-pancreatitis-with-a-median-follow-up-of-10-years
#7
Heikki Karjula, Arto Saarela, Pasi Ohtonen, Tero Ala-Kokko, Jyrki Mäkelä, Janne H Liisanantti
OBJECTIVE: To examine long-term survival and causes of death among working-age patients with acute pancreatitis (AP) compared with the normal population. SUMMARY OF BACKGROUND DATA: Few studies have investigated long-term survival after AP and recurrent AP compared with the normal population; moreover, results from those studies are difficult to compare, due to suboptimal control populations and wide variations in follow-up times. METHODS: This retrospective, registry-based study included 1644 patients with AP, aged 18 to 64 years, admitted to Oulu University Hospital in 1995 to 2012...
December 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29200128/tro40303-ameliorates-alcohol-induced-pancreatitis-through-reduction-of-fatty-acid-ethyl-ester-induced-mitochondrial-injury-and-necrotic-cell-death
#8
Muhammad Ahsan Javed, Li Wen, Muhammad Awais, Diane Latawiec, Wei Huang, Michael Chvanov, Sophie Schaller, Thierry Bordet, Magali Michaud, Rebecca Pruss, Alexei Tepikin, David Criddle, Robert Sutton
OBJECTIVES: Mitochondrial permeability transition pore inhibition is a promising approach to treat acute pancreatitis (AP). We sought to determine (i) the effects of the mitochondrial permeability transition pore inhibitor 3,5-seco-4-nor-cholestan-5-one oxime-3-ol (TRO40303) on murine and human pancreatic acinar cell (PAC) injury induced by fatty acid ethyl esters (FAEEs) or taurolithocholic acid-3-sulfate and (ii) TRO40303 pharmacokinetics and efficacy in experimental alcoholic AP (FAEE-AP)...
December 2, 2017: Pancreas
https://www.readbyqxmd.com/read/29195672/tobacco-and-alcohol-as-risk-factors-for-pancreatic-cancer
#9
REVIEW
Murray Korc, Christie Y Jeon, Mouad Edderkaoui, Stephen J Pandol, Maxim S Petrov
Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of immune microenvironment in pancreatic carcinogenesis activated by tobacco and alcohol...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29195671/alcohol-smoking-and-benign-hepato-biliary-disease
#10
REVIEW
Daniel Mønsted Shabanzadeh, Srdan Novovic
Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29190873/-segmental-portal-hypertension-with-splenic-vein-thrombosis-caused-by-pancreatitis
#11
Luis Franco-Avilés, Federico I Hernández-Rocha, Ulises Mercado, Cristian G Malvido-Torres
BACKGROUND: Splenic vein thrombosis is a complication of pancreatic carcinoma, pancreatitis or pancreatic pseudocyst. It may lead to segmental portal hypertension and bleeding from gastric varices. CLINICAL CASE: A 31 year-old man was diagnosed with pancreatitis of two weeks of evolution and was referred to our hospital in 2013. He had a history of alcohol consumption. Physical examination showed no stigmata of liver cirrhosis. Laboratory analyses revealed hemoglobin 9...
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29189884/adaptive-immune-cell-dysregulation-and-role-in-acute-pancreatitis-disease-progression-and-treatment
#12
REVIEW
Pascaline Fonteh, Martin Smith, Martin Brand
Acute pancreatitis (AP) is an inflammation of the pancreas caused by various stimuli including excessive alcohol consumption, gallstone disease and certain viral infections. Managing specifically the severe form of AP is limited due to lack of an understanding of the complex immune events that occur during AP involving immune cells and inflammatory molecules such as cytokines. The relative abundance of various immune cells resulting from the immune dysregulation drives disease progression. In this review, we examine the literature on the adaptive immune cells in AP, the prognostic value of these cells in stratifying patients into appropriate care and treatment strategies based on cell frequency in different AP severities are discussed...
November 30, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29188065/high-circulating-plasma-dipeptidyl-peptidase-4-levels-in-non-obese-asian-indians-with-type-2-diabetes-correlate-with-fasting-insulin-and-ldl-c-levels-triceps-skinfolds-total-intra-abdominal-adipose-tissue-volume-and-presence-of-diabetes-a-case-control-study
#13
Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, Ravindra Mohan Pandey, Harsh Mahajan
Aim: To evaluate circulating plasma dipeptidyl peptidase-4 (DPP4) levels in non-obese Asian Indians with type 2 diabetes mellitus (T2DM), and to correlate these with metabolic profile and measures of anthropometry, skinfolds, abdominal adipose tissue depots, pancreatic volume, and liver span. Methodology: Non-obese (body mass index (BMI) <25 kg/m2) patients with T2DM (cases, n=93), diagnosed within 1 year from recruitment, on metformin therapy and BMI-matched, and non-diabetic subjects (controls, n=40) were compared...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29174078/acute-pancreatitis-admission-trends-a-national-estimate-through-the-kids-inpatient-database
#14
Maisam Abu-El-Haija, Samer El-Dika, Alice Hinton, Darwin L Conwell
OBJECTIVES: To evaluate national health care use and costs for pediatric acute pancreatitis. STUDY DESIGN: The Kids' Inpatient Database for 2006, 2009, and 2012 was queried for patients with a principal diagnosis of acute pancreatitis. Cases were grouped by age: preschool (<5 years of age), school age (5-14 years of age), and adolescents (>14 years of age). RESULTS: A total of 27 983 discharges for acute pancreatitis were found. The number of admissions increased with age: young n = 1279, middle n = 8012, and older n = 18 692...
November 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29167024/evolving-treatment-of-necrotizing-pancreatitis
#15
Alexandra M Roch, Thomas Maatman, Rose A Carr, Jeffrey J Easler, C Max Schmidt, Michael G House, Attila Nakeeb, Eugene P Ceppa, Nicholas J Zyromski
BACKGROUND: Over the past decade, the treatment of necrotizing pancreatitis (NP) has incorporated greater use of minimally invasive techniques, including percutaneous drainage and endoscopic debridement. No study has yet compared outcomes of patients treated with all available techniques. We sought to evaluate the evolution of NP treatment at our high volume pancreas center. We hypothesized that minimally invasive techniques (medical only, percutaneous, and endoscopic) were used more frequently in later years...
November 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29150935/generation-of-insulin-producing-cells-from-human-adipose-derived-mesenchymal-stem-cells-on-pva-scaffold-by-optimized-differentiation-protocol
#16
Seyed Ehsan Enderami, Masoud Soleimani, Yousef Mortazavi, Samad Nadri, Ali Salimi
The studies have been done on patient-specific human adipose-derived from mesenchymal stem cells (hADSCs) like a series of autologous growth factors and nanofibrous scaffolds (3D culture) will probably have many benefits for regenerative medicine in type 1 diabetes mellitus (TIDM) patients in the future. For this purpose, we established a polyvinyl alcohol (PVA) scaffold and a differentiation protocol by adding platelet-rich plasma (PRP) that induces the hADSCs into insulin-producing cells (IPCs). The Characteristics of the derived IPCs in 3D culture were compared with conventional culture (2D) groups evaluated at the mRNA and protein levels...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29142480/case-of-familial-hyperlipoproteinemia-type-iii-hypertriglyceridemia-induced-acute-pancreatitis-role-for-outpatient-apheresis-maintenance-therapy
#17
Mohannad Abou Saleh, Emad Mansoor, Gregory S Cooper
Hypertriglyceridemic pancreatitis (HTGP) accounts for up to 10% of acute pancreatitis presentations in non-pregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type III who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29141370/-a-noteworthy-disease-non-alcoholic-fatty-pancreatic-disease
#18
P Y Liu, X W Liu, C Jiang
No abstract text is available yet for this article.
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29132523/pancreatitis-and-pancreatic-cancer
#19
REVIEW
Anne Walling, Robert Freelove
Most cases of acute pancreatitis are related to gallstones. More than 80% resolve within a few days. The diagnosis is based on upper abdominal pain, elevated lipase and/or amylase, and transabdominal ultrasound findings. Management requires early aggressive hydration, pain control, nutritional support, and monitoring for progression. Patients who develop hypovolemia, systemic inflammatory response, pancreatic necrosis, and organ failure have high mortality, risk of recurrence, and progression to chronic pancreatitis (CP)...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29121396/role-of-gut-derived-endotoxin-on-type-i-collagen-production-in-the-rat-pancreas-after-chronic-alcohol-exposure
#20
Hongyan Li, Ming Xiu, Shuhua Wang, David R Brigstock, Li Sun, Limei Qu, Runping Gao
BACKGROUND: Pancreatic fibrosis is a key pathological feature of alcoholic chronic pancreatitis (ACP). Bacterial endotoxin lipopolysaccharide (LPS) is considered as an important cofactor in the fibrogenesis of ACP. However, there are limitations in the use of exogenous LPS for evaluating the role of endotoxin in ACP pathogenesis. In this study we determined the relationship between the concentration of LPS in the portal vein and pancreatic type I collagen (Col1) content in chronic alcohol-fed rats...
November 9, 2017: Alcoholism, Clinical and Experimental Research
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