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alcoholic pancreatitis

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https://www.readbyqxmd.com/read/29033544/eluxadoline-in-the-treatment-of-diarrhea-predominant-irritable-bowel-syndrome
#1
REVIEW
Ayşe Elif Özdener, Anastasia Rivkin
Eluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline's efficacy in reducing symptoms related to IBS-D. Clinical trial results and postmarketing reports show a risk of pancreatitis in patients without a gallbladder or those abusing alcohol. This review article will include information on clinical trial results related to IBS-D management as well as eluxadoline's limitations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29026869/associations-between-antiretroviral-treatment-and-avascular-bone-necrosis-the-swiss-hiv-cohort-study
#2
Cornelia Bayard, Bruno Ledergerber, Markus Flepp, Thanh Lecompte, Estelle Moulin, Matthias Hoffmann, Rainer Weber, Cornelia Staehelin, Caroline Di Benedetto, Christoph A Fux, Philip E Tarr, Barbara Hasse
BACKGROUND: HIV-infected individuals have an increased risk of avascular bone necrosis (AVN). Antiretroviral therapy (ART) and particularly protease inhibitors (PI) have been implicated as a risk factor. We aimed to study the associations of ART with the occurrence of AVN among Swiss HIV Cohort Study participants (SHCS). METHODS: We used incidence density sampling to perform a case control study within the Swiss HIV Cohort Study (SHCS) comparing prospectively collected AVN cases and controls by conditional logistic regression analysis...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29025534/-endovascular-treatment-of-a-gastroduodenal-artery-pseudoaneurysm-rupture-after-a-car-accident
#3
Sofia Dutra, Filipe Veloso Gomes, Tiago Bilhim, Élia Coimbra
The authors present a case of a 39-year-old man with alcoholic chronic pancreatitis that was admitted in the emergency department after a car accident, complaining of abdominal pain and looking pale. The patient was hemodinamically unstable, requiring blood transfusions. He underwent computed tomography angiogram of the abdomen and pelvis, showing a pseudoaneurysm of the gastroduodenal artery and a hemoperitoneum. He was referred to our interventional radiology unit and submitted to endovascular treatment, consisting of 'backdoor' and 'frontdoor' embolization of the gastroduodenal artery and pseudoaneurysm neck with coils, with total exclusion in control angiography...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29021697/chronic-saponin-treatment-attenuates-damage-to-the-pancreas-in-chronic-alcohol-treated-diabetic-rats
#4
Mi Ran Choi, Su Min Kwak, Sol Hee Bang, Jo-Eun Jeong, Dai-Jin Kim
BACKGROUND: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats. METHODS: Long-Evans Tokushima Fatty (LETO) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats were pair-fed a Lieber-DeCarli diet with and without 5% ethanol for 12 wks...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29017085/diseases-of-the-pancreas-and-suicide-mortality-a-nationwide-nested-case-control-study-among-patients-with-mental-health-disorders-in-taiwan
#5
Hong-Ming Chen, Vincent Chin-Hung Chen, Tsu-Nai Wang, Mong-Liang Lu, Yin-Cheng Huang, Michael E Dewey, Johnny Kuang-Wu Lee, Ching-Piao Tsai
OBJECTIVE: Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study. METHODS: The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010...
September 29, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28991938/intraoral-lesion-%C3%A2-history-of-cirrhosis-and-smoking-%C3%A2-dx
#6
Ezinne I Ogbureke, Ruth E Conn, Dennis E Garcia, Cleverick D Johnson
A 56-year-old white man presented at our dental clinic for routine care. The intraoral examination revealed an asymptomatic red lesion with white vesicle-like areas on the right side of the soft palate. The extraoral examination was normal, and regional lymph nodes were nonpalpable. The patient's medical history included liver cirrhosis and pancreatitis. He also had a 30-year history of alcohol misuse (1-5 drinks per day) and a 30-pack-year smoking history. (The patient had stopped drinking at the time of presentation, and had quit smoking 2 years earlier...
October 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28988572/uniting-epidemiology-and-experimental-disease-models-for-alcohol-related-pancreatic-disease
#7
Veronica Wendy Setiawan, Kristine Monroe, Aurelia Lugea, Dhiraj Yadav, Stephen Pandol
Findings from epidemiologic studies and research with experimental animal models provide insights into alcohol-related disease pathogeneses. Epidemiologic data indicate that heavy drinking and smoking are associated with high rates of pancreatic disease. Less clear is the association between lower levels of drinking and pancreatitis. Intriguingly, a very low percentage of drinkers develop clinical pancreatitis. Experimental models demonstrate that alcohol administration alone does not initiate pancreatitis but does sensitize the pancreas to disease...
2017: Alcohol Research: Current Reviews
https://www.readbyqxmd.com/read/28984071/type-2-diabetes-does-pancreatic-fat-really-matter
#8
REVIEW
V Guglielmi, P Sbraccia
With obesity increasing prevalence, the interest of research in non alcoholic fatty pancreas disease (NAFPD) is grown. Even though the pancreas appears more susceptible to lipid accumulation compared to the liver, NAFPD has been less investigated due to the limits in detecting techniques. Several definitions and synonyms for NAFPD are used by authors and can be misleading. This, together with differences in methodology and ethnicity population, makes the integration and comparison of studies on this topic challenging...
October 5, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28971378/endoscopic-ultrasound-guided-transmural-drainage-of-walled-off-pancreatic-necrosis-in-patients-with-portal-hypertension-and-intra-abdominal-collaterals
#9
Surinder S Rana, Ravi Sharma, Sobur Uddin Ahmed, Rajesh Gupta
BACKGROUND: Acute necrotizing pancreatitis (ANP) is complicated with segmental portal hypertension (PHT) and formation of venous collaterals. Presence of collaterals in vicinity of endoscopic transmural tract can lead to potentially catastrophic situation. Here, we report safety and outcome of EUS-guided transmural drainage of walled-off pancreatic necrosis (WOPN) in patients with PHT and intra-abdominal collaterals. METHODS: Retrospective analysis of collected database of patients (n=18; age 40...
October 2, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28968289/ctrc-genetic-variants-including-c-180tt-are-strongly-associated-with-chronic-pancreatitis-in-paediatric-patients
#10
Alicja Monika Grabarczyk, Grzegorz Oracz, Katarzyna Wertheim-Tysarowska, Aleksandra Anna Kujko, Karolina Wejnarska, Elwira Kolodziejczyk, Jerzy Bal, Dorota Koziel, Artur Kowalik, Stanislaw Gluszek, Agnieszka Magdalena Rygiel
Genetic studies in adults/adolescent patients with chronic pancreatitis (CP) identified chymotrypsinogen C (CTRC) genetic variants but their association with CP risk have been difficult to replicate. OBJECTIVE: To evaluate the risk of CP associated with CTRC variants in CP paediatric patients-control study. DESIGN: The distribution of CTRC variants in CP paediatric cohort (n = 136, median age at CP onset 8 years) with no history of alcohol/smoking abuse was compared to controls (n = 401, median age 45)...
September 29, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28966560/crystal-nucleation-using-surface-energy-modified-glass-substrates
#11
Kyle A Nordquist, Kevin M Schaab, Jierui Sha, Andrew H Bond
Systematic surface energy modifications to glass substrates can induce nucleation and improve crystallization outcomes for small molecule active pharmaceutical ingredients (APIs) and proteins. A comparatively broad probe for function is presented in which various APIs, proteins, organic solvents, aqueous media, surface energy motifs, crystallization methods, form factors, and flat and convex surface energy modifications were examined. Replicate studies (n ≥ 6) have demonstrated an average reduction in crystallization onset times of 52(4)% (alternatively 52 ± 4%) for acetylsalicylic acid from 91% isopropyl alcohol using two very different techniques: bulk cooling to 0 °C using flat surface energy modifications or microdomain cooling to 4 °C from the interior of a glass capillary having convex surface energy modifications that were immersed in the solution...
August 2, 2017: Crystal Growth & Design
https://www.readbyqxmd.com/read/28958672/severe-hypertriglyceridemia-in-japan-differences-in-causes-and-therapeutic-responses
#12
Toshio Murase, Minoru Okubo, Tetsu Ebara, Yasumichi Mori
BACKGROUND: Severe hypertriglyceridemia (>1000 mg/dL) has a variety of causes and frequently leads to life-threating acute pancreatitis. However, the origins of this disorder are unclear for many patients. OBJECTIVE: We aimed to characterize the causes of and responses to therapy in rare cases of severe hypertriglyceridemia in a group of Japanese patients. METHODS: We enrolled 121 patients from a series of case studies that spanned 30 years...
August 24, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28957814/prevalence-and-incidence-of-autoimmune-pancreatitis-in-the-population-living-in-the-southwest-of-germany
#13
Alexander Schneider, Henrik Michaely, Christel Weiss, Michael Hirth, Felix Rückert, Torsten J Wilhelm, Stefan Schönberg, Alexander Marx, Manfred V Singer, J Matthias Löhr, Matthias P Ebert, Roland H Pfützer
BACKGROUND/AIMS: The prevalence and incidence of autoimmune pancreatitis (AiP) in those living in western countries are largely unknown. We aimed to determine the prevalence of AiP among patients with pancreatitis presenting to our tertiary referral center in Mannheim, Germany; and to estimate the incidence of AiP in the Southwest of Germany. METHODS: We performed a retrospective cross-sectional analysis and determined the prevalence of AiP in patients with acute pancreatitis (AP) or chronic pancreatitis (CP)...
September 29, 2017: Digestion
https://www.readbyqxmd.com/read/28948113/one-of-the-largest-pancreatic-pseudocysts-in-the-literature-a-case-report
#14
Sulaiman Alhassan, Shifa Umar, Mark Lega
The pancreatic pseudocyst is a pancreatic fluid collection which classically develops due to acute or chronic pancreatitis. A 68-year-old male with the remote history of alcohol abuse presented with abdominal pain secondary to acute pancreatitis. The first computed tomography (CT) of the abdomen showed acute necrotizing pancreatitis. He was initially treated conservatively. Repeat CT of the abdomen after two weeks revealed a peripancreatic fluid collection of 20x12x10 cm. One month later, he became septic following biliary stent placement...
July 20, 2017: Curēus
https://www.readbyqxmd.com/read/28942551/androgen-excess-and-metabolic-disorders-in-women-with-pcos-beyond-the-body-mass-index
#15
REVIEW
R A Condorelli, A E Calogero, M Di Mauro, L M Mongioi', R Cannarella, G Rosta, S La Vignera
BACKGROUND: Insulin resistance is a common feature among women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic anovulation. PCOS women are at risk for developing metabolic syndrome, impaired glucose tolerance and type II diabetes mellitus (DM II). OBJECTIVE: The aim of this review is to explore the existing knowledge of the interplay between androgen excess, pancreatic β-cell function, non-alcoholic fatty liver disease (NAFLD), intra-abdominal and subcutaneous (SC) abdominal adipocytes in PCOS, providing a better comprehension of the molecular mechanisms of diabetologic interest...
September 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28939212/fortilin-a-potential-target-for-the-prevention-and-treatment-of-human-diseases
#16
Decha Pinkaew, Ken Fujise
Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca(2+)) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28935139/the-prevalence-of-underweight-is-increased-in-chronic-pancreatitis-outpatients-and-associates-with-reduced-life-quality
#17
Søren S Olesen, Louise Kuhlman Frandsen, Jakob Lykke Poulsen, Peter Vestergaard, Henrik Højgaard Rasmussen, Asbjørn M Drewes
BACKGROUND: Underweight is a well-known complication of chronic pancreatitis (CP), but little is known about its prevalence in the outpatient setting. We investigated the prevalence of underweight in outpatients with CP and its association with quality of life (QOL) and various risk factors. METHODS: This was a cross-sectional study of 166 outpatients with CP that was conducted at a tertiary referral center. The primary outcome was the prevalence of underweight (body mass index [BMI] <20 kg/m(2)) in patients with CP compared with 160 age- and sex-matched controls...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#18
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28927476/antioxidant-intake-from-diet-and-supplements-and-risk-of-digestive-cancers-in-middle-aged-adults-results-from-the-prospective-nutrinet-sant%C3%A3-cohort
#19
Manon Egnell, Philippine Fassier, Lucie Lécuyer, Rebeca Gonzalez, Laurent Zelek, Marie-Paule Vasson, Serge Hercberg, Paule Latino-Martel, Pilar Galan, Nathalie Druesne-Pecollo, Mélanie Deschasaux, Mathilde Touvier
Experimental studies suggest beneficial effects of antioxidants in digestive cancer prevention. However, epidemiological results are contrasting and few studies quantitatively assessed supplemental intake. This study aimed at investigating the associations between antioxidant intakes (dietary, supplemental and total) and digestive cancer risk. This prospective study included 38 812 middle-aged subjects (≥45 years) from the NutriNet-Santé cohort (2009-2016). Dietary data were collected using repeated 24 h records...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28921377/basophils-activated-via-tlr-signaling-may-contribute-to-pathophysiology-of-type-1-autoimmune-pancreatitis
#20
Masato Yanagawa, Kazushige Uchida, Yugo Ando, Takashi Tomiyama, Takashi Yamaguchi, Tsukasa Ikeura, Toshiro Fukui, Akiyoshi Nishio, Yoshiko Uemura, Takayuki Miyara, Hiroyuki Okamoto, Souhei Satoi, Kazuichi Okazaki
BACKGROUND: Pathophysiology of type 1 autoimmune pancreatitis (AIP) is still unclear. We previously reported that M2 macrophages might play an important role in type 1 AIP. Recently, it has been reported that basophils regulate differentiation to M2 macrophages. In this study, we investigated basophils from the pancreatic tissue and peripheral blood of individuals with type 1 AIP. METHODS: By using immunohistochemistry, we investigated basophils in pancreatic tissue from 13 patients with type 1 AIP and examined expression of toll-like receptors (TLRs) by these cells...
September 18, 2017: Journal of Gastroenterology
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