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Gynecologic cervical disease

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https://www.readbyqxmd.com/read/29755594/perineural-invasion-in-early-stage-cervical-cancer-and-its-relevance-following-surgery
#1
Yi Zhu, Guonan Zhang, Yan Yang, Ling Cui, Shijun Jia, Yu Shi, Shuiqin Song, Shiqiang Xu
Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that has attracted attention as a novel prognostic factor for cancer. The present study aimed to investigate the prognostic value of PNI in patients with early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2-IIA). A total of 210 patients who underwent radical hysterectomy and pelvic lymphadenectomy between 2007 and 2012 were included in the current study, of whom 8.57% (18/210) exhibited PNI...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29747270/-prognostic-analysis-of-stage-%C3%A2-b2-and%C3%A2-a2-cervical-squamous-cancer-without-high-risk-factors-treated-with-neo-adjuvant-chemotherapy-and-radical-hysterectomy
#2
P P Li, B Li, Y T Wang, S H Liu, Y N Zhang, R Zhang, P Bai, X G Li, L Y Wu
Objective: To analyze the prognosis of Ⅰb2 and Ⅱa2 cervical squamous cancer without high risk factors treated with neo-adjuvant chemotherapy (NACT) and radical hysterectomy. Methods: This retrospective study included patients with International Federation of Gynecology and Obstetrics (FIGO) stage Ⅰ b2 and Ⅱ a2 cervical squamous cancer without high risk factors who underwent platinum-based NACT followed by radical surgery from January 2008 to January 2015. The responses of NACT were observed and compared in their effect on postoperative pathologic risk factors...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29742673/trends-in-place-of-death-among-patients-with-gynecologic-cancer-in-the-united-states
#3
Katherine Hicks-Courant, Alexander Melamed, Michael J Worley, Young Bae Kim, John O Schorge, J Alejandro Rauh-Hain
OBJECTIVE: To describe the change over time in place of death (hospital, home, hospice) among all women in the United States who died of gynecologic malignancies and compare them with other leading causes of female cancer deaths. METHODS: This is a retrospective cross-sectional study using national death certificate data from the Mortality Multiple Cause-of-Death Public Use Record Data. All women who died from gynecologic, breast, lung, and colorectal cancers were identified according to International Classification of Diseases, 10 Revision, cause of death from 2003 to 2015...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742668/effects-of-the-affordable-care-act-on-young-women-with-gynecologic-cancers
#4
Anna Jo Bodurtha Smith, Amanda N Fader
OBJECTIVE: To evaluate the effects of the dependent coverage mandate of the 2010 Affordable Care Act (ACA) on insurance status, stage at diagnosis, and receipt of fertility-sparing treatment among young women with gynecologic cancer. METHODS: We used a difference-in-differences design to assess insurance status, stage at diagnosis (stage I-II vs III-IV), and receipt of fertility-spearing treatment before and after the 2010 ACA among young women aged 21-26 years vs women aged 27-35 years...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29736362/preoperative-elevated-platelet-count-as-a-prognostic-factor-in-vulvar-squamous-cell-cancer-a-mini-review
#5
REVIEW
Ahmed Abu-Zaid, Osama Alomar, Hany Salem
Preoperative thrombocytosis has been shown to be a marker of advanced disease and poor survival in gynecologic malignancies, specifically endometrial, ovarian, and cervical cancers. The aim of this study is to provide a focused mini-review on all the existing literature concerning the role of preoperative thrombocytosis as a prognostic factor in vulvar squamous cell cancer (SCC). A PubMed search (until February 20, 2018) of all peer-reviewed and English-published articles was conducted using the following keywords: platelet, thrombocytosis, and vulvar cancer...
March 6, 2018: Curēus
https://www.readbyqxmd.com/read/29729635/an-integrative-investigation-of-the-therapeutic-mechanism-of-ainsliaea-fragrans-champ-in-cervicitis-using-liquid-chromatography-tandem-mass-spectrometry-based-on-a-rat-plasma-metabolomics-strategy
#6
Xiaoyong Zhang, Mingzhen He, Shuangxia Lei, Bei Wu, Ting Tan, Hui Ouyang, Wen Xu, Yulin Feng
Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Ainsliaea fragrans Champ. (AFC) has been widely used in clinical treatment of cervicitis. In the present study, we performed an integrative investigation involving histopathology analysis and non-target plasma metabolomics analysis in a cervicitis rat model induced by phenol mucilage, using ultra-performance liquid chromatography coupled with a tandem quadrupole time-of-flight mass spectrometry approach...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29725757/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#7
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie-Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 4, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29716674/microrna-411-inhibits-cervical-cancer-progression-by-directly-targeting-stat3
#8
Dan Shan, Yumin Shang, Tongxiu Hu
Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths inwomen around the world. Substantial evidence has proved that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Therefore, identification of miRNAs and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer...
May 1, 2018: Oncology Research
https://www.readbyqxmd.com/read/29701005/cytomegalovirus-cmv-in-cervical-cancer-screening-tests-a-series-of-8-cases-and-review-of-the-literature
#9
REVIEW
Paul A Elgert, Melissa Yee-Chang, Aylin Simsir
OBJECTIVE: Cytomegalovirus (CMV) is a ubiquitous infection typically affecting over 50% of the US population by age 40. We report 8 cases of CMV infections detected in cervical cancer screening tests, the largest series of cases thus far reported in gynecologic cytology specimens. METHODS: A retrospective review of our pathology archival computer database was performed from January 1, 1994 through December 31, 2016 for CMV infections reported in cervical cytology specimens...
April 26, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#10
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29671223/laparoscopic-paraaortic-surgical-staging-in-locally-advanced-cervical-cancer-a-single-center-experience
#11
D Vázquez-Vicente, B Fernández Del Bas, J García Villayzán, H A Di Fiore, J Luna Tirado, V Casado Echarren, J García-Foncillas, J Plaza Arranz, L Chiva
BACKGROUND: One aim of this study was to assess the efficacy and safety of laparoscopic paraaortic lymphadenectomy for paraaortic lymph node staging in locally advanced cervical carcinoma. The second aim was to identify prognostic factors in the evolution of this disease and to evaluate how the results of the surgery modify the oncological treatment of patients. MATERIALS AND METHODS: We analyzed 59 patients diagnosed with locally advanced cervical cancer International Federation of Gynecology and Obstetrics stage IB2-IVA who underwent laparoscopic paraaortic lymphadenectomy at our hospital between 2009 and 2015...
April 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29670527/comparative-metabolomics-analysis-of-cervicitis-in-human-patients-and-a-phenol-mucilage-induced-rat-model-using-liquid-chromatography-tandem-mass-spectrometry
#12
Xiaoyong Zhang, Junmao Li, Bin Xie, Bei Wu, Shuangxia Lei, Yun Yao, Mingzhen He, Hui Ouyang, Yulin Feng, Wen Xu, Shilin Yang
Cervicitis is an exceedingly common gynecological disorder that puts women at high risk of sexually transmitted infections and induces a series of reproductive system diseases. This condition also has a significant impact on quality of life and is commonly misdiagnosed in clinical practice due to its complicated pathogenesis. In the present study, we performed non-targeted plasma metabolomics analysis of cervicitis in both plasma samples obtained from human patients and plasma samples from a phenol mucilage induced rat model of cervicitis, using ultra-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29668367/which-patients-with-cervical-squamous-cell-carcinoma-might-benefit-from-neoadjuvant-chemotherapy
#13
Omar Mahmoud, Mark H Einstein
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
April 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29661497/postoperative-chemotherapy-for-node-positive-cervical-cancer-results-of-a-multicenter-phase-ii-trial-jgog1067
#14
Maki Matoda, Nobuhiro Takeshima, Hirofumi Michimae, Takashi Iwata, Harushige Yokota, Yutaka Torii, Yorito Yamamoto, Kazuhiro Takehara, Shin Nishio, Hirokuni Takano, Mika Mizuno, Yoshiyuki Takahashi, Yuji Takei, Tetsuya Hasegawa, Mikio Mikami, Takayuki Enomoto, Daisuke Aoki, Toru Sugiyama
OBJECTIVE: This multicenter phase II Japanese Gynecologic Oncology Group study (JGOG1067) was designed to evaluate the efficacy and safety of postoperative chemotherapy in patients with node-positive cervical cancer. METHODS: Patients with stage IB-IIA squamous cervical cancer who underwent radical hysterectomy and were confirmed to have pelvic lymph node metastasis were eligible for this study. The patients postoperatively received irinotecan (CPT-11; 60mg/m2 intravenously on days 1 and 8) and nedaplatin (NDP; 80mg/m2 intravenously on day 1)...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29650191/supportive-care-needs-and-quality-of-life-of-patients-with-gynecological-cancer-undergoing-therapy
#15
Riska Hediya Putri, Yati Afiyanti, Titin Ungsianik, Ariesta Milanti
OBJECTIVE: To identify the relationship of unmet supportive care needs with quality of life of patients with gynecological cancer undergoing therapy. METHOD: This study used a cross-sectional design. A total of 153 patients with gynecological cancer undergoing therapy were recruited using consecutive sampling methods. The participants completed the questionnaire of Supportive Care Needs Survey to identify their supportive care needs, EORTC-QLQ 30 to assess their general quality of life, and EORTC-QLQ-CX 24 or - OV 28 to determine cancer-specific quality of life in cervical cancer and ovarian cancer, respectively...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29621040/concomitant-repair-of-pelvic-floor-disorders-in-women-undergoing-surgery-for-gynecologic-malignancies
#16
Katarzyna Bochenska, Margaret Mueller, Julia Geynisman-Tan, Alix Leader-Cramer, Bhumy Davé, Christina Lewicky-Gaupp, Kimberly Kenton
OBJECTIVE: The aims of this study were to determine the rate and describe 30-day postoperative complications of concomitant pelvic organ prolapse and/or urinary incontinence (POPUI) procedures in women undergoing surgery for a gynecologic malignancy. METHODS: Women who underwent surgical intervention for a gynecologic malignancy between 2010 and 2014 were identified using postoperative International Classification of Diseases, Ninth Revision codes 179.0 to 184.9 in the American College of Surgeons National Surgical Quality Improvement Program database...
April 4, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29620659/individualized-pelvic-lymphadenectomy-should-follow-neoadjuvant-concurrent-chemoradiotherapy-for-locally-advanced-cervical-cancer
#17
Li-Chun Wei, Xin Li, Ying Zhang, Yun-Zhi Dang, Wei-Wei Li, Jian-Ping Li, Li-Na Zhao, Shu-Juan Liu, Xia Li, Mei Shi
To study the outcomes following concurrent chemoradiotherapy (CCRT) and subsequent radical surgery for locally advanced cervical cancer (LACC), analyze the relationship between imaging-diagnosed and postoperative-diagnosed lymph node (LN) involvement, and identify patients who would benefit from individualized pelvic lymphadenectomy.We retrospectively reviewed records of 410 patients who underwent CCRT followed by radical surgery for International Federation of Gynecology and Obstetrics Stage Ib2-IIIb disease...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29609232/-clinical-significance-of-loop-electrosurgical-excisional-procedure-in-diagnosis-and-treatment-of-cervical-adenocarcinoma-in-situ-and-invasive-cervical-adenocarcinoma
#18
Y Song, Q Wang, L Sui, S J Gao
Objective: To evaluate the accuracy of colposcopic biopsy on diagnosis of cervical adenocarcinoma in situ (AIS) and the clinical significance of loop electrosurgical excisional procedure (LEEP) on diagnosis and treatment of AIS and invasive adenocarcinoma. Methods: All medical records of 193 patients diagnosed as AIS by colposcopic biopsy and (or) AIS or invasive adenocarcinoma diagnosed by LEEP conization from Jan. 2015 to Dec. 2016 in Obstetrics and Gynecology Hospital of Fudan University were retrospectively reviewed...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29605054/investigating-black-white-disparities-in-gynecologic-oncology-theories-conceptual-models-and-applications
#19
REVIEW
Kemi M Doll
Within gynecologic oncology are two of the top five widest Black-White mortality gaps among all cancer diagnoses in the United States. A rich body of work from the social sciences, including anthropology, sociology and social epidemiology, have broadened the understanding of and research approaches to the study of health and healthcare inequity experienced by Black Americans. Yet, these intellectual advancements in understanding are virtually absent from the gynecologic oncology literature. The goal of this analytic essay will be to introduce three current frameworks of studying racial inequity: The Ecosocial Theory of Disease Distribution, The Fundamental Cause Theory, and The Public Health Critical Race Praxis...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29605053/a-contemporary-framework-of-health-equity-applied-to-gynecologic-cancer-care-a-society-of-gynecologic-oncology-evidenced-based-review
#20
REVIEW
Sarah M Temkin, B J Rimel, Amanda S Bruegl, Camille C Gunderson, Anna L Beavis, Kemi M Doll
Health disparities are defined as the preventable difference in the burden of disease, injury, and violence, or opportunity to achieve optimal health that socially disadvantaged populations experience compared to the population as a whole. Disparities in incidence and cancer outcomes for women with gynecologic malignancies have been well described particularly for American women of Black race. The etiology of these disparities has been tied to socio-economics, cultural, educational and genetic factors. While access to high quality treatment has been primarily linked to survival from cervical and ovarian cancer, innate biologic distinctions have been principally cited as reasons for differences in incidence and mortality in cancers of the uterine corpus...
April 2018: Gynecologic Oncology
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