keyword
https://read.qxmd.com/read/38535323/in-silico-analysis-of-novel-bacterial-metabolites-with-anticancer-activities
#1
JOURNAL ARTICLE
Pfariso Maumela, Mahloro Hope Serepa-Dlamini
Resistance to anticancer therapeutics is a major global concern. Thus, new anticancer agents should be aimed against novel protein targets to effectively mitigate the increased resistance. This study evaluated the potential of secondary metabolites from a bacterial endophyte, as new anticancer agents, against a novel protein target, fibroblast growth factor. In silico genomic characterization of the Bacillus sp. strain MHSD_37 was used to identify potential genes involved in encoding secondary metabolites with biological activity...
March 13, 2024: Metabolites
https://read.qxmd.com/read/38535084/novel-biomarkers-in-evaluating-cardiac-function-in-patients-on-hemodialysis-a-pilot-prospective-observational-cohort-study
#2
JOURNAL ARTICLE
Lazar Chisavu, Viviana Mihaela Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller
Chronic kidney disease patients treated by hemodialysis present a high cardiovascular morbidity and mortality. There is an imperative need for novel biomarkers for identifying these patients and to offer possible therapeutically interventions. We performed a prospective observational cohort study on 77 patients in the period of October 2021-October 2023. We measured serum plasma levels of interleukin 1-beta, galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion site...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#3
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534395/if1-promotes-cellular-proliferation-and-inhibits-oxidative-phosphorylation-in-mouse-embryonic-fibroblasts-under-normoxia-and-hypoxia
#4
JOURNAL ARTICLE
Lothar Lauterboeck, Sung Wook Kang, Donnell White, Rong Bao, Parnia Mobasheran, Qinglin Yang
ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is well-established that IF1 interacts with the F1 sector of ATP synthase to inhibit the reversal rotation and, thus, ATP hydrolysis. Recent evidence supports that IF1 also inhibits forward rotation or the ATP synthesis activity. Adding to the complexity, IF1 may also facilitate mitophagy and cristae formation. The implications of these complex actions of IF1 for cellular function remain obscure...
March 21, 2024: Cells
https://read.qxmd.com/read/38534333/cd74-promotes-cyst-growth-and-renal-fibrosis-in-autosomal-dominant-polycystic-kidney-disease
#5
JOURNAL ARTICLE
Julie Xia Zhou, Alice Shasha Cheng, Li Chen, Linda Xiaoyan Li, Ewud Agborbesong, Vicente E Torres, Peter C Harris, Xiaogang Li
The progression of autosomal dominant polycystic kidney disease (ADPKD), an inherited kidney disease, is associated with renal interstitial inflammation and fibrosis. CD74 has been known not only as a receptor of macrophage migration inhibitory factor (MIF) it can also have MIF independent functions. In this study, we report unknown roles and function of CD74 in ADPKD. We show that knockout of CD74 delays cyst growth in Pkd1 mutant kidneys. Knockout and knockdown of CD74 (1) normalize PKD associated signaling pathways, including ERK, mTOR and Rb to decrease Pkd1 mutant renal epithelial cell proliferation, (2) decrease the activation of NF-κB and the expression of MCP-1 and TNF-alpha (TNF-α) which decreases the recruitment of macrophages in Pkd1 mutant kidneys, and (3) decrease renal fibrosis in Pkd1 mutant kidneys...
March 11, 2024: Cells
https://read.qxmd.com/read/38532813/sirt1-inhibits-atrial-fibrosis-by-downregulating-the-expression-of-the-transforming-growth-factor-%C3%AE-1-smad-pathway
#6
JOURNAL ARTICLE
Yiqi Chen, Shuting Zhao, Hua Xiao
BACKGROUND: Atrial fibrosis is an important factor leading to atrial fibrillation, and the transforming growth factor-β1/Smad pathway is a key factor in inducing atrial fibrosis. Sirt1 is a member of the histone deacetylase (sirtuin) family, and recent studies have proven its cardioprotective effects. OBJECTIVES: This study explored the effect of Sirt1 on atrial fibrosis through the transforming growth factor-β1/Smad pathway. METHODS: We analyzed human right atrial appendage tissues and explored the relationship between Sirt1 and atrial fibrosis at the morphological, functional and molecular levels by Masson trichrome staining, immunofluorescence, real-time quantitative polymerase chain reaction and Western blot analysis...
March 2024: Acta Cardiologica Sinica
https://read.qxmd.com/read/38532197/expression-of-fibroblast-growth-factor-receptor-2-fgfr2-in-combined-hepatocellular-cholangiocarcinoma-and-intrahepatic-cholangiocarcinoma-clinicopathological-study
#7
JOURNAL ARTICLE
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Genetic alterations including fusions in fibroblast growth factor receptor 2 (FGFR2) are detected in 10-20% of intrahepatic cholangiocarcinoma (iCCA), and FGFR2 inhibitors are effective for the treatment of iCCA. We examined a prevalence of FGFR2 genetic alterations and their clinicopathological significance in combined hepatocellular-cholangiocarcinoma (cHCC-CCA). FGFR2 expression, which is a surrogate marker for FGFR2 genetic alterations, was immunohistochemically assessed in the liver sections from 75 patients with cHCC-CCA, 35 with small duct-type iCCA, 30 with large duct-type iCCA, and 35 with hepatocellular carcinoma (HCC)...
March 27, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38532028/pdgfra-k385-mutants-in-myxoid-glioneuronal-tumors-promote-receptor-dimerization-and-oncogenic-signaling
#8
JOURNAL ARTICLE
Laurence de Villenfagne, Ariane Sablon, Jean-Baptiste Demoulin
Myxoid glioneuronal tumors (MGNT) are low-grade glioneuronal neoplasms composed of oligodendrocyte-like cells in a mucin-rich stroma. These tumors feature a unique dinucleotide change at codon 385 in the platelet-derived growth factor receptor α (encoded by the PDGFRA gene), resulting in the substitution of lysine 385 into leucine or isoleucine. The functional consequences of these mutations remain largely unexplored. Here, we demonstrated their oncogenic potential in fibroblast and Ba/F3 transformation assays...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530370/ga11-deficiency-increases-fibroblast-growth-factor-23-levels-in-a-mouse-model-of-familial-hypocalciuric-hypercalcemia
#9
JOURNAL ARTICLE
Birol Ay, Sajin Marcus Cyr, Kaitlin Klovdahl, Wen Zhou, Christina M Tognoni, Yorihiro Iwasaki, Eugene P Rhee, Alpaslan Dedeoglu, Petra Simic, Murat Bastepe
Fibroblast Growth Factor 23 (FGF23) production has recently been shown to increase downstream of G⍺q/11-PKC signaling in osteocytes. Inactivating mutations in the gene encoding G⍺11 (GNA11) cause familial hypocalciuric hypercalcemia (FHH) due to impaired calcium-sensing receptor signaling. We explored the impact of G⍺11 deficiency on FGF23 production in mice with heterozygous (Gna11+/-) or homozygous (Gna11-/-) ablation of Gna11. Both Gna11+/- and Gna11-/- mice demonstrated hypercalcemia and mildly raised parathyroid hormone levels, consistent with FHH...
March 26, 2024: JCI Insight
https://read.qxmd.com/read/38530319/serum-fibroblast-growth-factor-19-level-correlates-inversely-with-clinical-and-endoscopic-activity-of-inflammatory-bowel-disease
#10
JOURNAL ARTICLE
Agata Łukawska, Agata Mulak
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition with relapsing-remitting course. Diarrhea and abdominal pain are the most common IBD symptoms. Fibroblast growth factor 19 (FGF19) is an endocrine factor that inhibits hepatic bile acid production and may be used as a diagnostic marker for bile acid malabsorption. OBJECTIVES: To assess serum FGF19 levels in active and inactive phases of IBD and find a potential correlation between FGF19 and disease activity...
March 26, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38529321/molecular-regulation-of-transforming-growth-factor-%C3%AE-1-induced-thioredoxin-interacting-protein-ubiquitination-and-proteasomal-degradation-in-lung-fibroblasts-implication-in-pulmonary-fibrosis
#11
JOURNAL ARTICLE
Sarah J Taleb, Qinmao Ye, Boina Baoyinna, Michael Dedad, Dakshin Pisini, Narasimham L Parinandi, Lewis C Cantley, Jing Zhao, Yutong Zhao
Thioredoxin-interacting protein (TXNIP) plays a critical role in regulation of cellular redox reactions and inflammatory responses by interacting with thioredoxin (TRX) or the inflammasome. The role of TXNIP in lung fibrosis and molecular regulation of its stability have not been well studied. Therefore, here we investigated the molecular regulation of TXNIP stability and its role in TGF-β1-mediated signaling in lung fibroblasts. TXNIP protein levels were significantly decreased in lung tissues from bleomycin-challenged mice...
March 2024: J Respir Biol Transl Med
https://read.qxmd.com/read/38528813/population-pharmacokinetic-pharmacodynamic-modeling-of-serum-biomarkers-as-predictors-of-tumor-dynamics-following-lenvatinib-treatment-in-patients-with-radioiodine-refractory-differentiated-thyroid-cancer-rr-dtc
#12
JOURNAL ARTICLE
Oneeb Majid, Seiichi Hayato, Sree Harsha Sreerama Reddy, Bojan Lalovic, Taro Hihara, Taisuke Hoshi, Yasuhiro Funahashi, Jagadeesh Aluri, Osamu Takenaka, Sanae Yasuda, Ziad Hussein
Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial growth factor (VEGF) receptors 1-3, fibroblast growth factor (FGF) receptors 1-4, platelet-derived growth factor receptor-α (PDGFRα), KIT, and RET that have been implicated in pathogenic angiogenesis, tumor growth, and cancer. The primary objective of this work was to evaluate, by establishing quantitative relationships, whether lenvatinib exposure and longitudinal serum biomarker data (VEGF, Ang-2, Tie-2, and FGF-23) are predictors for change in longitudinal tumor size which was assessed based on data from 558 patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC) receiving either lenvatinib or placebo treatment...
March 26, 2024: CPT: Pharmacometrics & Systems Pharmacology
https://read.qxmd.com/read/38528565/the-upregulation-of-vgf-enhances-the-progression-of-oral-squamous-carcinoma
#13
JOURNAL ARTICLE
Chung-Hsien Chou, Chun-Han Yen, Chung-Ji Liu, Hsi-Feng Tu, Shu-Chun Lin, Kuo-Wei Chang
BACKGROUND: Oral squamous cell carcinoma (OSCC) is a prevalent neoplasm worldwide, necessitating a deeper understanding of its pathogenesis. VGF nerve growth factor inducible (VGF), a neuropeptide, plays critical roles in nerve and endocrine cell regulation. METHODS: In this study, the TCGA datasets were initially screened, identifying the upregulation of VGF in various malignancies. We focused on OSCC cell lines, identifying the suppressor mRNA miR-432-5p as a negative regulator of VGF...
March 25, 2024: Cancer Cell International
https://read.qxmd.com/read/38528341/construction-and-characterization-of-a-functional-variant-hfgf7-with-enhanced-properties-by-circular-permutation
#14
JOURNAL ARTICLE
Hye-Ji Choi, Hanui Lee, Dae-Eun Cheong, Su-Kyoung Yoo, Dong-Eun Lee, Geun-Joong Kim
Human fibroblast growth factor 7 (hFGF7) is a member of the paracrine-acting FGF family and mediates various reactions such as wound healing, tissue homeostasis, and liver regeneration. These activities make it a plausible candidate for pharmaceutical applications as a drug. However, the low expression level and stability of the recombinant hFGF7 were known to be major hurdles for further applications. Here, the expression level and stability of hFGF7 were attempted to improve by changing the order of amino acids through circular permutation (CP), thereby expecting an alternative fate according to the N-end rule...
March 2024: Biotechnology Journal
https://read.qxmd.com/read/38528099/impact-of-media-supplements-fgf2-lif-and-igf1-on-the-genome-activity-of-porcine-embryos-produced-in-vitro
#15
JOURNAL ARTICLE
Alexandra Rosenbaum Bartkova, Lucie Nemcova, Frantisek Strejcek, Ahmed Gad, Veronika Kinterova, Martin Morovic, Michal Benc, Radek Prochazka, Jozef Laurincik
In this article, we focused on the impact of precisely chemically modified FLI maturation medium enriched with fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), insulin-like growth factor 1 (IGF1), and polyvinyl alcohol (PVA) and its potential to improve the efficiency of in vitro production of porcine embryos. We hypothesized that enhancing the composition of the maturation medium could result in an elevated production of embryos in vitro and can affect EGA. FLI medium resulted in a significantly higher rate of oocyte blastocyst maturation and formation compared to the control DMEM medium...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38528089/ketotifen-directly-modifies-the-fibrotic-response-of-human-skin-fibroblasts
#16
JOURNAL ARTICLE
Edwin Leong, Haya Al-Bitar, Jean S Marshall, Michael Bezuhly
Fibrosis is a destructive, end-stage disease process. In the skin, it is associated with systemic sclerosis and scarring with considerable health burden. Ketotifen is a clinical antihistamine and mast cell stabilizer. Studies have demonstrated mast cell-dependent anti-fibrotic effects of ketotifen but direct effects on fibroblasts have not been determined. Human dermal fibroblasts were treated with pro-fibrotic transforming growth factor-β1 (TGFβ) followed by ketotifen or control treatments to determine direct effects on fibrotic fibroblasts...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527968/predictive-factors-of-periodontal-regeneration-outcomes-using-rhfgf-2-a-case-control-study
#17
JOURNAL ARTICLE
Shinji Matsuda, Tomoya Ueda, Fuminori Nakashima, Yurika Ninomiya, Keisuke Yasuda, Shinya Sasaki, Yuta Hamamoto, Tomoyuki Iwata, Kazuhisa Ouhara, Naoki Mihara, Naoya Kakimoto, Noriyoshi Mizuno
OBJECTIVE: This study aimed to investigate the factors influencing the clinical outcomes of regenerative therapy using recombinant human fibroblast growth factor-2 (rhFGF-2). BACKGROUND: rhFGF-2 promotes periodontal regeneration, and identifying the factors influencing this regeneration is important for optimizing the effectiveness of rhFGF-2. METHODS AND MATERIALS: This study used a hospital information-integrated database to identify patients who underwent periodontal regenerative therapy with rhFGF-2...
March 25, 2024: Journal of Periodontal Research
https://read.qxmd.com/read/38527859/exploring-the-modulatory-effects-of-sotagliflozin-on-dyslipidemia-in-mice-the-role-of-glucagon-fibroblast-growth-factor-21-and-glucagon-like-peptide-1
#18
JOURNAL ARTICLE
Nitin J Deshmukh, M S Kalshetti, Mohan Patil, Pankaj Autade, Ganesh V Sangle
Sotagliflozin is the first dual SGLT1/2 inhibitor antidiabetic drug approved by the US Food and Drug Administration for the management of heart failure. SGLT1/2 inhibition is observed to potentiate the secretion of the incretin hormone, glucagon-like peptide-1 (GLP-1). The current preclinical research sought to investigate the effect of sotagliflozin on the secretion of fat-regulating peptides such as GLP-1, glucagon and fibroblast growth factor 21 (FGF21) and their prospective association with sotagliflozin's potential beneficial effects on dyslipidaemia...
May 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38527685/redox-mechanisms-in-autoimmune-thyroid-eye-disease
#19
REVIEW
Francesco Buonfiglio, Katharina A Ponto, Norbert Pfeiffer, George J Kahaly, Adrian Gericke
Thyroid eye disease (TED) is an autoimmune condition affecting the orbit and the eye with its adnexa, often occurring as an extrathyroidal complication of Graves' disease (GD). Orbital inflammatory infiltration and the stimulation of orbital fibroblasts, triggering de novo adipogenesis, an overproduction of hyaluronan, myofibroblast differentiation, and eventual tissue fibrosis are hallmarks of the disease. Notably, several redox signaling pathways have been shown to intensify inflammation and to promote adipogenesis, myofibroblast differentiation, and fibrogenesis by upregulating potent cytokines, such as interleukin (IL)-1β, IL-6, and transforming growth factor (TGF)-β...
March 23, 2024: Autoimmunity Reviews
https://read.qxmd.com/read/38526215/characterization-of-individual-bile-acids-in-vivo-utilizing-a-novel-low-bile-acid-mouse-model
#20
JOURNAL ARTICLE
Rulaiha Taylor, Zhenning Yang, Zakiyah Henry, Gina Capece, Vik Meadows, Katherine Otersen, Veronia Basaly, Anisha Bhattacharya, Stephanie Mera, Peihong Zhou, Laurie Joseph, Ill Yang, Anita Brinker, Brian Buckley, Bo Kong, Grace L Guo
Bile acids (BAs) are signaling molecules synthesized in the liver initially by CYP7A1 and CYP27A1 in the classical and alternative pathways, respectively. BAs are essential for cholesterol clearance, intestinal absorption of lipids, and endogenous modulators of farnesoid x receptor (FXR). FXR is critical in maintaining BA homeostasis and gut-liver crosstalk. Complex reactions in vivo and the lack of suitable animal models impede our understanding of the functions of individual BAs. In this study, we characterized the in vivo effects of three-day feeding of cholic acid (CA), deoxycholic acid (DCA), or ursodeoxycholic acid (UDCA) at physiological/non-hepatotoxic concentrations in a novel low-BA mouse model (Cyp7a1  -/-/Cyp27a1  -/-, DKO)...
March 25, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
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