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https://www.readbyqxmd.com/read/29055191/design-isolation-and-evaluation-of-the-binding-efficiency-of-a-dna-aptamer-against-interleukin-2-receptor-alpha-in-vitro
#1
Mahin Shahdordizadeh, Seyed Mohammad Taghdisi, Mojtaba Sankian, Mohammad Ramezani, Khalil Abnous
High levels of CD25, as part of the IL-2 receptor, are expressed on the surface of the activated T lymphocytes and regulatory T cells, indicating that the soluble CD25 (sCD25) could be a clinically valuable tool for treating several diseases. Moreover, progress has been achieved in targeting the IL-2 receptor to treat autoimmune diseases, organ transplantation and certain hematological malignancies. In the current study, generation of an ssDNA aptamer (Apt51) against CD25 is reported. Apt51 bound to CD25 with high affinity (Kd=13...
October 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29055190/pinocembrin-attenuates-allergic-airway-inflammation-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-in-mice
#2
Xiaoyan Gu, Qian Zhang, Qiang Du, Hong Shen, Zhenghua Zhu
Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mechanism. BALB/c mice sensitized and challenged with OVA were administered intraperitoneally with pinocembrin. Airway inflammation and airway hyperresponsiveness were examined. T-helper type (Th) 2 cytokines in bronchoalveolar lavage fluid (BALF) and OVA-specific immunoglobulin E (IgE) in serum were determined...
October 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29054963/interleukin-12-mediated-expression-of-matrix-metalloproteinases-in-human-periodontal-ligament-fibroblasts-involves-in-nf-kappab-activation
#3
Li Miao, Shujun Zhan, Jiyan Liu
Interleukin (IL-12) is a pro-inflammatory cytokine, and its increased level correlates with the severity of periodontitis. However, its role in the pathogenesis of tooth periapical lesions is controversial and has not been completely clarified. This study aimed to investigate whether IL-12 affects the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in human periodontal ligament fibroblasts (hPDLFs). After treatment with IL-12 for different time, Real-time PCR and Western blotting were used to determine the mRNA and protein levels of MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1 and TIMP-2, respectively...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29050115/-effects-of-ovalbumin-exposure-during-pregnancy-of-mice-on-the-ovalbumin-re-exposure-in-adult-progeny
#4
Z Song, H Q Li
Objective: To observe the immunoreaction of offspring mice by ovalbumin (OVA) re-exposure after their mothers exposed to OVA during pregnancy. Method: A prospective controlled study was conducted to observe mice after repeated OVA exposures at 6-8 weeks.Their mothers were exposed to OVA during different stages of pregnancy.The symptoms were recorded and scored.The levels of OVA-specific IgE in serum, interferon-γ(IFN-γ) and interleukin-4(IL-4) in supernatant of spleen primary lymphocytes in vitro were measured by ELISA...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29045902/epidermal-growth-factor-receptor-expression-licenses-type-2-helper-t-cells-to-function-in-a-t-cell-receptor-independent-fashion
#5
Carlos M Minutti, Sebastian Drube, Natalie Blair, Christian Schwartz, Jame C McCrae, Andrew N McKenzie, Thomas Kamradt, Michal Mokry, Paul J Coffer, Maria Sibilia, Alice J Sijts, Padraic G Fallon, Rick M Maizels, Dietmar M Zaiss
Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29042873/comparison-of-cytokine-expression-profiles-in-infants-with-a-rhinovirus-induced-lower-respiratory-tract-infection-with-or-without-wheezing-a-comparison-with-respiratory-syncytial-virus
#6
Da Eun Roh, Sook-Hyun Park, Hee Joung Choi, Yeo Hyang Kim
PURPOSE: The aim of this study was to evaluate whether infants with rhinovirus (RV) infection-induced wheezing and those with respiratory syncytial virus (RSV) infection-induced wheezing have different cytokine profiles in the acute stage. METHODS: Of the infants with lower respiratory tract infection (LRTI) between September 2011 and May 2012, 88 were confirmed using reverse transcription polymerase chain reaction and hospitalized. Systemic interferon-gamma (IFN-γ), interleukin (IL)-2, IL-12, IL-4, IL-5, IL-13, and Treg-type cytokine (IL-10) responses were examined with multiplex assay using acute phase serum samples...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#7
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29039549/downregulation-of-caspase%C3%A2-3-alleviates-mycoplasma%C3%A2-pneumoniae%C3%A2-induced-apoptosis-in-alveolar-epithelial-cells
#8
Shan Shi, Xiaolei Liu, Haibo Li
Mycoplasma pneumoniae (M. pneumoniae) infection is closely associated with pneumonia in children. Apoptosis of alveolar epithelial cells is involved in the development of pneumonia in children. The present study aimed to examine how caspase‑3 influences apoptosis rates in M. pneumoniae‑infected alveolar epithelial cells. A549 alveolar epithelial cells were treated with M. pneumoniae, and cells and culture supernatant were collected at different time points. Alterations in apoptosis rates and caspase‑3 mRNA and protein levels were measured for each treatment group...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039501/isoimperatorin-ameliorates-osteoarthritis-by-downregulating-the-mammalian-target-of-rapamycin-c1-signaling-pathway
#9
Jiayao Ouyang, Huaji Jiang, Hang Fang, Wenbo Cui, Daozhang Cai
Osteoarthritis (OA) is the most common disease of the joints, and is characterized by the breakdown of cartilage and degradation of the extracellular matrix. OA causes a high level of patient suffering and incurs large societal costs; however, the current strategies for treating OA are restricted due to limited understanding of the underlying molecular and cellular mechanisms. In the present study, the beneficial effects of isoimperatorin (Iso) were investigated using an experimental mouse model of OA, and its mechanism of action on primary chondrocytes was elucidated...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039445/isoliquiritigenin-suppresses-il-1%C3%AE-induced-apoptosis-and-inflammation-in-chondrocyte-like-atdc5-cells-by-inhibiting-nf-%C3%AE%C2%BAb-and-exerts-chondroprotective-effects-on-a-mouse-model-of-anterior-cruciate-ligament-transection
#10
Baochao Ji, Wentao Guo, Hairong Ma, Boyong Xu, Wenbo Mu, Zhendong Zhang, Abdusami Amat, Li Cao
Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of the nuclear factor-κB (NF-κB) signaling pathway and anti-inflammatory activity in a wide variety of cells. In the present study, the authors first evaluated the effects of ISL on cartilage degeneration in interleukin-1β (IL-1β)-stimulated chondrocyte-like ATDC5 cells and in a mouse model of osteoarthritis (OA). The data of a cell counting kit-8 and flow cytometry assay indicated that ISL suppressed the inhibitory effect of IL-1β on cell viability...
October 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29037330/waist-circumference-shows-the-highest-predictive-value-for-metabolic-syndrome-and-waist-to-hip-ratio-for-its-components-in-spanish-adolescents
#11
Javier S Perona, Jacqueline Schmidt-RioValle, Blanca Rueda-Medina, María Correa-Rodríguez, Emilio González-Jiménez
Both waist circumference (WC) and waist-to-hip ratio (WHR) have been proposed as predictors of metabolic syndrome (MetS) in adolescents, but no consensus has been reached to date. This study hypothesizes that WC provides a greater predictive value for MetS in Spanish adolescents than WHR. A cross-sectional study was performed on 1001 adolescents (13.2 ± 1.2 years) randomly recruited from schools in southeast Spain. Anthropometric measures were correlated with the components of MetS (triglycerides, glucose, blood pressure, and high-density lipoprotein cholesterol) as well as inflammation markers (interleukin-6 and tumor necrosis factor-alpha , C-reactive protein, and ceruloplasmin)...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29036956/-the-diagnostic-value-of-neuron-specific-enolase-central-nervous-system-specific-protein-and-interleukin-6-in-sepsis-associated-encephalopathy
#12
Q Feng, L Wu, Y H Ai, S Y Deng, M L Ai, L Huang, Z Y Liu, L N Zhang
Objective: To investigate the diagnostic value of neuron-specific enolase(NSE), central nervous system specific protein(S100β), interleukin-6(IL-6) in sepsis-associated encephalopathy(SAE). Methods: Clinical data of patients admitted to ICU and diagnosed with sepsis were collected from January 2015 to June 2016 in Xiangya Hospital, Central South University. SAE was defined as cerebral dysfunction in the presence of sepsis that also fulfilled the exclusion criteria. The acute physiology and chronic health score (APACHE Ⅱ), sequential organ failure assessment (SOFA), NSE, S100β, IL-6, ICU stay time and 28-day mortality were compared between the two groups...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036019/targeting-the-interleukin-4-and-interleukin-13-pathways-in-severe-asthma-current-knowledge-and-future-needs
#13
Amit D Parulekar, Christina C Kao, Zuzana Diamant, Nicola A Hanania
PURPOSE OF REVIEW: Severe asthma is a heterogeneous disease that can be classified into phenotypes and endotypes based upon clinical or biological characteristics. Interleukin (IL)-4 and IL-13 play a key role in type 2 (T2) asthma. This article reviews the signaling pathway of IL-4 and IL-13 and highlights its targeted therapy in severe asthma. RECENT FINDINGS: Several clinical trials of biologics targeting the IL-4/IL-13 pathway have recently been completed. In patients with severe, uncontrolled asthma, targeting IL-13 alone with biologics including lebrikizumab and tralokinumab has not shown consistent reduction in asthma exacerbations...
October 13, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29035815/genipin-inhibits-allergic-responses-in-ovalbumin-induced-asthmatic-mice
#14
Je-Won Ko, Na-Rae Shin, Sung-Hyeuk Park, Young-Kwon Cho, Jong-Choon Kim, Chang-Seob Seo, In-Sik Shin
Genipin is a natural compound isolated from the fruit of Gardenia jasminoides with various pharmacological effects. In this study, we investigated whether genipin effectively alleviates allergic responses in a murine model of ovalbumin (OVA)-induced asthma. The mice were administered an intraperitoneal injection of OVA on day 0 and 14 to boost the immune response; genipin was then administered from day 18 to 23 by oral gavage. On days 21 to 23, mice were OVA-challenged using am ultrasonic nebulizer, and airway hyperresponsiveness (AHR) was determined on day 24 by plethysmography...
October 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29035099/association-between-growth-differentiation-factor-15-and-left-ventricular-hypertrophy-in-hypertensive-patients-and-healthy-adults
#15
Huijuan Kou, Xin Jin, Dengfeng Gao, Rui Ma, Xin Dong, Jin Wei, Xin Wang
Growth differentiation factor 15 (GDF-15) as an independent biomarker of cardiovascular diseases merits further evaluation. We studied the association between plasma GDF-15 levels and left ventricular hypertrophy (LVH) in hypertensive patients and healthy adults. Hypertensive LVH measurements were performed via echocardiography and analyzed using the cube formula, and human GDF-15 together with interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) concentrations were determined via enzyme-linked immunosorbent assay (ELISA)...
October 16, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29034234/interleukin-13-in-asthma-and-other-eosinophilic-disorders
#16
Emma Doran, Fang Cai, Cécile T J Holweg, Kit Wong, Jochen Brumm, Joseph R Arron
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity, asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. While it is appreciated that eosinophilia is present in only a subset of patients, it remains a key feature of asthma and other eosinophilic disorders such as atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis with nasal polyps...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033851/effects-of-alpha-lactalbumin-or-whey-protein-isolate-on-muscle-damage-muscle-pain-and-mood-states-following-prolonged-strenuous-endurance-exercise
#17
Lu Qin, Stephen H S Wong, Feng-Hua Sun, Yu Huang, Sinead Sheridan, Cindy H P Sit
This study compared the effect of alpha-lactalbumin and whey protein on muscle damage, muscle pain, and mood states during short term recovery following strenuous prolonged exercise. In a two-stage crossover counterbalanced design, 12 endurance male runners were recruited (age: 30.4 ± 2.8 year, height: 172.7 ± 5.6 cm, body mass: 66.7 ± 6.5 kg, VO2max: 58.0 ± 6.9 ml/kg(-)/min), ran for 90 min at 70% VO2max, and followed by a 4-h recovery. Two treatments (carbohydrate+alpha-lactalbumin, CA; carbohydrate+whey protein isolate, CW) were applied during the main trials...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29032686/3-hydroxypterostilbene-suppresses-colitis-associated-tumorigenesis-by-inhibition-of-il-6-stat3-signaling-in-mice
#18
Ching-Shu Lai, Guliangyang Yang, Shiming Li, Pei-Sheng Lee, Bini Wang, Min-Ching Chung, Kalyanam Nagabhushanam, Min-Hsiung Pan, Chi-Tang Ho
3'-Hydroxypterostilbene (trans-3,5-dimethoxy-3',4'-hydroxystilbene) presents in Sphaerophysa salsula, Pterocarpus marsupium, and Honey Bee propolis and has been reported to exhibit several biological activities. Herein, we aimed to explore the chemopreventive effects of dietary 3'-hydroxypterostilbene and underlying molecular mechanisms on colitis-associated cancer using the azoxymethane (AOM)/dextran sodium sulfate (DSS) model. 3'-Hydroxypterostilbene administration effectively ameliorated the colon shortening and number of tumors in AOM/DSS-treated mice (3...
October 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29030400/microrna-signature-of-cigarette-smoking-and-evidence-for-a-putative-causal-role-of-micrornas-in-smoking-related-inflammation-and-target-organ-damage
#19
Christine M Willinger, Jian Rong, Kahraman Tanriverdi, Paul L Courchesne, Tianxiao Huan, Gregory A Wasserman, Honghuang Lin, Josée Dupuis, Roby Joehanes, Matthew R Jones, George Chen, Emelia J Benjamin, George T O'Connor, Joseph P Mizgerd, Jane E Freedman, Martin G Larson, Daniel Levy
BACKGROUND: Cigarette smoking increases risk for multiple diseases. MicroRNAs regulate gene expression and may play a role in smoking-induced target organ damage. We sought to describe a microRNA signature of cigarette smoking and relate it to smoking-associated clinical phenotypes, gene expression, and lung inflammatory signaling. METHODS AND RESULTS: Expression profiling of 283 microRNAs was conducted on whole blood-derived RNA from 5023 Framingham Heart Study participants (54...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29029618/balneotherapeutic-effects-of-high-mineral-spring-water-on-the-atopic-dermatitis-like-inflammation-in-hairless-mice-via-immunomodulation-and-redox-balance
#20
Johny Bajgai, Ailyn Fadriquela, Jesmin Ara, Rahima Begum, Md Faruk Ahmed, Cheol-Su Kim, Soo-Ki Kim, Kwang-Yong Shim, Kyu-Jae Lee
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these inflammatory diseases include anti-histamines, corticosteroids and calcineurin inhibitors but these drugs have their limitations such as adverse effects with their long-term usage. Thus, researcher's interest in several alternative and complementary therapies are continually growing and balneotherapy is one of these approaches...
October 13, 2017: BMC Complementary and Alternative Medicine
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