keyword
MENU ▼
Read by QxMD icon Read
search

interleukin 13

keyword
https://www.readbyqxmd.com/read/29221287/anti-cancer-activity-of-dose-fractioned-mpe-bevacizumab-regimen-is-paralleled-by-immune-modulation-in-advanced-squamous-nslc-patients
#1
Pierpaolo Pastina, Valerio Nardone, Stefania Croci, Giuseppe Battaglia, Francesca Vanni, Cristiana Bellan, Marcella Barbarino, Veronica Ricci, Susan Costantini, Francesca Capone, Cirino Botta, Mayra Rachele Zarone, Gabriella Misso, Mariarosaria Boccellino, Michele Caraglia, Antonio Giordano, Piero Paladini, Pierfrancesco Tassone, Pierosandro Tagliaferri, Maria Grazia Cusi, Luigi Pirtoli, Pierpaolo Correale
Background: Results from the BEVA2007 trial, suggest that the metronomic chemotherapy regimen with dose-fractioned cisplatin and oral etoposide (mPE) +/- bevacizumab, a monoclonal antibody to the vascular endothelial growth factor (VEGF), shows anti-angiogenic and immunological effects and is a safe and active treatment for metastatic non-small cell lung cancer (mNSCLC) patients. We carried out a retrospective analysis aimed to evaluate the antitumor effects of this treatment in a subset of patients with squamous histology...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217840/the-role-of-anxious-distress-in-immune-dysregulation-in-patients-with-major-depressive-disorder
#2
Roxanne Gaspersz, Femke Lamers, Gayle Wittenberg, Aartjan T F Beekman, Albert M van Hemert, Robert A Schoevers, Brenda W J H Penninx
Although depression with anxious distress appears to be a clinically relevant subtype of major depressive disorder (MDD), whether it involves specific pathophysiology remains unclear. Inflammation has been implicated, but not comprehensively studied. We examined within a large MDD sample whether anxious distress and related anxiety features are associated with differential basal inflammation and innate cytokine production capacity. Data are from 1078 MDD patients from the Netherlands Study of Depression and Anxiety...
December 8, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29216945/-expression-and-meaning-of-t-bet-and-gata3-mrna-in-t-lymphocyte-of-patients-during-the-operation-with-cardiopulmonary-bypass
#3
Haifeng Ni, Yingbin Xiao
OBJECTIVE: To investigate the effects of cardiopulmonary bypass (CPB) on the differentiation of T lymphocyte subsets and the expression of specific transcription regulator T-bet/GATA binding protein 3 (GATA3). METHODS: A prospective double-blind study was conducted. Patients with CPB pulmonary repair of ventricular septal defect (observation group) or off-pump ligation of ductus arteriosus (control group) with 20 cases each in the 150th Military Hospital from February 2015 to February 2016 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216941/-impact-of-unfractionated-heparin-on-serum-and-liver-tissue-expression-of-heparanase-in-the-liver-injury-of-mice-with-sepsis
#4
Ziwei Hu, Xiaojuan Zhang, Song Chen, Ran Zhu, Xiaochun Ma
OBJECTIVE: To investigate the effect of unfractionated heparin on the expression of serum and liver tissue heparanase (HPA) in mice with liver injury induced by sepsis. METHODS: Forty-eight healthy male C57BL/6 mice aged 6-8 weeks were divided into groups according to random number table method. Twenty-four septic mice models (CLP group) were established by cecal ligation and puncture (CLP); the other 24 mice underwent sham operation (sham group), only laparotomy and abdominal closure were performed without ligation...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29214554/geniposide-suppresses-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-chondrocytes-via-the-pi3k-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#5
Tianlong Pan, Xuchao Shi, Huan Chen, Rong Chen, Dengying Wu, Zeng Lin, Jingdong Zhang, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is principally characterized by progressive joint dysfunction and cartilage degradation. Inflammation and apoptosis play critical roles in the progression of OA. Geniposide (GPO), one of the principal components of the fruit of Gardenia jasminoides Ellis, has been reported to have anti-inflammatory and other pharmacological effects. In this study, we performed in vitro experiments on rat chondrocytes to examine the therapeutic effects of GPO on OA and investigated its effects in vivo in a rat model of OA induced by medial meniscal tear (MMT)...
December 6, 2017: Inflammation
https://www.readbyqxmd.com/read/29213245/implication-of-free-fatty-acids-in-thrombin-generation-and-fibrinolysis-in-vascular-inflammation-in-zucker-rats-and-evolution-with-aging
#6
Jérémy Lagrange, Mélusine Didelot, Amel Mohamadi, Lucy A Walton, Saartje Bloemen, Bas de Laat, Huguette Louis, Simon N Thornton, Brian Derby, Michael J Sherratt, Bruno Fève, Pascal Challande, Riaz Akhtar, J Kennedy Cruickshank, Patrick Lacolley, Véronique Regnault
Background: The metabolic syndrome (MetS) and aging are associated with modifications in blood coagulation factors, vascular inflammation, and increased risk of thrombosis. Objectives: Our aim was to determine concomitant changes in thrombin generation in the blood compartment and at the surface of vascular smooth muscle cells (VSMCs) and its interplay with adipokines, free fatty acids (FFA), and metalloproteinases (MMPs) in obese Zucker rats that share features of the human MetS. Methods: Obese and age-matched lean Zucker rats were compared at 25 and 80 weeks of age...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29212559/the-body-remembers-adolescent-conflict-struggles-predict-adult-interleukin-6-levels
#7
Joseph P Allen, Emily L Loeb, Joseph S Tan, Rachel K Narr, Bert N Uchino
Struggles managing conflict and hostility in adolescent social relationships were examined as long-term predictors of immune-mediated inflammation in adulthood that has been linked to long-term health outcomes. Circulating levels of interleukin-6 (IL-6), a marker of immune system dysfunction when chronically elevated, were assessed at age 28 in a community sample of 127 individuals followed via multiple methods and reporters from ages 13 to 28. Adult serum IL-6 levels were predicted across periods as long as 15 years by adolescents' inability to defuse peer aggression and poor peer-rated conflict resolution skills, and by independently observed romantic partner hostility in late adolescence...
December 7, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29211635/association-of-il-13-rs20541-and-rs1295686-variants-with-symptomatic-asthma-in-a-saudi-arabian-population
#8
Rabih Halwani, Alejandro Vazquez-Tello, Rosan Kenana, Maram Al-Otaibi, Khalid A Alhasan, Zahid Shakoor, Saleh Al-Muhsen
OBJECTIVE: Interleukin 13 (IL-13) plays a critical pro-inflammatory role in asthma. Several single nucleotide polymorphisms (SNPs) are associated with asthma susceptibility in specific populations; however, further replicative studies in other ethnic groups are mandatory. METHODS: The association between IL-13 SNPs rs762534, rs20541, rs1295686, and rs1800925 (risk alleles A, A, T, and A, respectively) and asthma predisposition in a Saudi Arabian cohort was examined via a case-control cross-sectional study...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29208967/a-selective-inhibition-of-c-fos-activator-protein-1-as-a-potential-therapeutic-target-for-intervertebral-disc-degeneration-and-associated-pain
#9
Hiroto Makino, Shoji Seki, Yasuhito Yahara, Shunichi Shiozawa, Yukihiko Aikawa, Hiraku Motomura, Makiko Nogami, Kenta Watanabe, Takeshi Sainoh, Hisakatsu Ito, Noriyuki Tsumaki, Yoshiharu Kawaguchi, Mitsuaki Yamazaki, Tomoatsu Kimura
Intervertebral disc (IVD) degeneration is a major cause of low back pain. The transcription factor c-Fos/Activator Protein-1 (AP-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) that contribute to the pathogenesis IVD degeneration. We investigated the effects of inhibition of c-Fos/AP-1 on IVD degeneration and associated pain. A selective inhibitor, T-5224, significantly suppressed the interleukin-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription in human nucleus pulposus cells and in a mouse explant culture model of IVD degeneration...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208260/ghrelin-ameliorates-asthma-by-inhibiting-endoplasmic-reticulum-stress
#10
Tian Fu, Lei Wang, Qingdi Zeng, Yan Zhang, Baowei Sheng, Liping Han
BACKGROUND: This study aimed to confirm the ameliorative effect of ghrelin on asthma and investigate its mechanism. MATERIALS AND METHODS: The murine model of asthma was induced by ovalbumin (OVA) treatment and assessed by histological pathology and airway responsiveness to methacholine. The total and differential leukocytes were counted. Tumor necrosis factor α, interferon γ, interleukin-5 and interleukin-13 levels in bronchoalveolar lavage fluid were quantified by commercial kits...
December 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29203888/insight-into-the-molecular-recognition-mechanism-of-the-coactivator-ncoa1-by-stat6
#11
Luigi Russo, Karin Giller, Edith Pfitzner, Christian Griesinger, Stefan Becker
Crucial for immune and anti-inflammatory cellular responses, signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 and -13 -induced tyrosine phosphorylation by direct interaction with coactivators. The interaction of STAT6 with nuclear coactivator 1 (NCoA1) is mediated by a short region of the STAT6 transactivation domain that includes the motif LXXLL and interacts with the PAS-B domain of NCoA1. Despite the availability of an X-ray structure of the PAS-B domain/ Leu794-Gly814-STAT6 complex, the mechanistic details of this interaction are still poorly understood...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203859/interleukin-13-receptor-alpha-2-cooperates-with-egfrviii-signaling-to-promote-glioblastoma-multiforme
#12
Jennifer P Newman, Grace Y Wang, Kazuhiko Arima, Shou P Guan, Michael R Waters, Webster K Cavenee, Edward Pan, Edita Aliwarga, Siao T Chong, Catherine Y L Kok, Berwini B Endaya, Amyn A Habib, Tomohisa Horibe, Wai H Ng, Ivy A W Ho, Kam M Hui, Tomasz Kordula, Paula Y P Lam
The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in normal brain which makes it a highly suitable target for diagnostic and therapeutic purposes. However, the pathological role of this receptor in GBM remains to be established. Here we report that IL-13Rα2 alone induces invasiveness of human GBM cells without affecting their proliferation. In contrast, in the presence of the mutant EGFR (EGFRvIII), IL-13Rα2 promotes GBM cell proliferation in vitro and in vivo...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29203240/il-13-regulates-il-17c-expression-by-suppressing-nf-%C3%AE%C2%BAb-mediated-transcriptional-activation-in-airway-epithelial-cells
#13
Katsumasa Yamanaka, Tomoyuki Fujisawa, Hideki Kusagaya, Kazutaka Mori, Mitsuru Niwa, Kazuki Furuhashi, Masato Kono, Etsuko Hamada, Takafumi Suda, Masato Maekawa
The cytokine interleukin (IL)-17C is highly expressed in epithelial tissues and involved in innate immune responses; however, the regulation of IL-17C expression in the airways remains poorly understood. Here, we show that IL-1β strongly induces both IL-17C mRNA and protein expression in primary normal human bronchial epithelial cells. Conversely, IL-13 significantly reduced the IL-1β-induced IL-17C expression. Attenuation of the nuclear factor (NF)-κB-signaling pathway using an NF-κB-subunit p65-specific small-interfering RNA (siRNA), reduced IL-1β-induced IL-17C expression, demonstrating the importance of NF-κB signaling in IL-17C regulation...
December 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29200756/g2a-attenuates-propionibacterium-acnes-induction-of-inflammatory-cytokines-in-human-monocytes
#14
Andrew J Park, George W Agak, Min Qin, Lisa D Hisaw, Aslan Pirouz, Stephanie Kao, Laura J Marinelli, Hermes J Garbán, Diane Thiboutot, Philip T Liu, Jenny Kim
Background: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by which a lipid receptor, G2A, regulates immune responses to a commensal bacterium. Objective: To elucidate the inflammatory properties of G2A in monocytes in response to PA stimulation. Furthermore, our study sought to investigate pathways by which lipids modulate immune responses in response to PA...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29200312/levels-of-circulating-cortisol-and-cytokines-in-members-of-the-canadian-armed-forces-associations-with-age-sex-and-anthropometry
#15
Hans Christian Tingelstad, Lionel G Filion, Julie Martin, Michael Spivock, Vera Tang, François Haman
OBJECTIVE: To assess blood levels of cortisol and cytokines (inflammatory and non-inflammatory) in members of the regular Canadian Armed Forces (CAF), and examine the associations between sex, age and adiposity and circulating levels of cortisol as well as pro- and anti-inflammatory cytokines. METHODS: As part of a larger ranging project, 331 blood samples were collected from a representative population of the total CAF, which included officers and non-commissioned women and men from the Air Force, Navy and Army...
December 4, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29200094/characteristics-of-a-national-level-female-weightlifter-peaking-for-competition-a-case-study
#16
Caleb D Bazyler, Satoshi Mizuguchi, Michael C Zourdos, Kimitake Sato, Ashley A Kavanaugh, Brad H DeWeese, Kevin F Breuel, Michael H Stone
This study investigated physiological and performance changes of a national level 69kg female weightlifter following three competition phases over a 28-week training period. The athlete first trained for a regional championship (weeks 1-12), followed by a local competition (weeks 13-23) and the national championship (weeks 24-28). Body mass, vastus lateralis cross-sectional area, and unloaded and loaded squat jump performance were assessed weekly during each 4-week competition phase. Serum biomarkers, and dynamic mid-thigh pulls were assessed prior to and after each competition phase...
December 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29199785/acute-effect-of-moderate-intensity-concentric-and-eccentric-exercise-on-cardiac-effort-perceived-exertion-and-interleukin-6-level-in-physically-inactive-males
#17
Mayank Agarwal, Shraddha Singh, Priyanka Sharma, Rahul Saini
BACKGROUND: Muscle-derived interleukin-6 (IL-6) not only enhances glucose and fat metabolism but also has an anti-inflammatory effect that can prevent the development of cardiovascular disease (CVD) and metabolic syndrome. Dynamic resistance exercise comprises a muscle shortening and a lengthening phase known as concentric and eccentric contraction respectively. We compared an acute bout of concentric exercise (CE) with eccentric exercise (EE) for the serum IL-6 concentration, myocardial oxygen consumption (MVO2) and rating of perceived exertion (RPE)...
December 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29199257/-retinoic-acid-prevents-dendritic-cells-from-inducing-novel-inflammatory-t-cells-that-produce-abundant-interleukin-13
#18
Aya Yokota-Nakatsuma
 Vitamin A (VA) plays critical roles in gut homeostasis. Dendritic cells in mesenteric lymph nodes (MLN-DCs) can metabolize VA to retinoic acid (RA), thereby inducing gut-tropic lymphocytes and enhancing peripheral differentiation of regulatory T cells expressing forkhead box P3. We found that MLN-DCs from VA-deficient mice induced a distinct inflammatory T helper type 2 (Th2)-cell subset that produced abundant interleukin-13 (IL-13) and expressed receptors for homing to skin and inflammatory sites but not to the intestine...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29198746/valproic-acid-attenuates-inflammation-of-optic-nerve-and-apoptosis-of-retinal-ganglion-cells-in-a-rat-model-of-optic-neuritis
#19
Qiang Liu, Haining Li, Juan Yang, Xiaoyan Niu, Chunmei Zhao, Li Zhao, Zhenhai Wang
AIMS: Optic neuritis (ON) is an inflammatory disease of the optic nerve, which often occurs in patients with multiple sclerosis (MS) and leads to retinal ganglion cell (RGC) death and even severe visual loss. Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects. Here, we examined the effects of VPA in experimental autoimmune encephalomyelitis (EAE) rats and explored the underlying mechanisms. MAIN METHODS: EAE was induced by subcutaneous injection with myelin basic protein, emulsified with complete Freund's adjuvant and Mycobacterium tuberculosis H37Ra into the Lewis rats...
November 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29198314/t-cell-resistance-to-activation-by-dendritic-cells-requires-long-term-culture-in-simulated-microgravity
#20
Jillian H Bradley, Rachel Stein, Brad Randolph, Emily Molina, Jennifer P Arnold, Randal K Gregg
Immune impairment mediated by microgravity threatens the success of space exploration requiring long-duration spaceflight. The cells of most concern, T lymphocytes, coordinate the host response against microbial and cancerous challenges leading to elimination and long-term protection. T cells are activated upon recognition of specific microbial peptides bound on the surface of antigen presenting cells, such as dendritic cells (DC). Subsequently, this engagement results in T cell proliferation and differentiation into effector T cells driven by autocrine interleukin-2 (IL-2) and other cytokines...
November 2017: Life Sciences in Space Research
keyword
keyword
56102
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"