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interleukin 10

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https://www.readbyqxmd.com/read/28340008/pre-treatment-interleukin-6-levels-strongly-affect-bone-erosion-progression-and-repair-detected-by-magnetic-resonance-imaging-in-rheumatoid-arthritis-patients
#1
Yasushi Kondo, Yuko Kaneko, Hiroaki Sugiura, Shunsuke Matsumoto, Naoshi Nishina, Masataka Kuwana, Masahiro Jinzaki, Tsutomu Takeuchi
Objective.: To examine the relationship between MRI structural damage and repair and plasma inflammatory cytokines in patients with RA. Methods.: A total of 88 newly diagnosed, untreated RA patients were enrolled. Contrast MRI of the dominant hand and X-rays of the hands and feet were performed at baseline and 1 year later. MR images were evaluated using RA MRI scoring, and X-ray. were assessed by the modified total Sharp score. Erosion progression was defined as changes in RA MRI scoring erosion or modified total Sharp score erosion of >0...
March 8, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339731/obesity-associated-cardiac-pathogenesis-in-broiler-breeder-hens-development-of-metabolic-cardiomyopathy2-3
#2
C Y Chen, Y F Huang, Y J Ko, Y J Liu, Y H Chen, R L Walzem, S E Chen
Feed intake is typically restricted (R) in broiler hens to avoid obesity and improve egg production and livability. To determine whether improved heart health contributes to improved livability, fully adult 45-week-old R hens were allowed to consume feed to appetite (ad libitum; AL) up to 10 wk (70 d). Mortality, contractile functions, and morphology at 70 d, and measurements of cardiac hypertrophic remodeling at 7 d and 21 d were made and compared between R and AL hens. Outcomes for cardiac electrophysiology and mortality, reported separately, found increased mortality in AL hens in association with cardiac pathological hypertrophy and contractile dysfunction...
February 22, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339618/telomere-length-oxidative-stress-inflammation-and-bdnf-levels-in-siblings-of-patients-with-bipolar-disorder-implications-for-accelerated-cellular-aging
#3
Mirela Paiva Vasconcelos-Moreno, Gabriel Rodrigo Fries, Carolina Gubert, Bárbara Tietböhl Martins Quadros Dos Santos, Adam Fijtman, Juliana Sartori, Pamela Ferrari, Lucas Kich Grun, Mariana Migliorini Parisi, Fátima Theresinha Costa Rodrigues Guma, Florencia Maria Barbé-Tuana, Flávio Kapczinski, Adriane Ribeiro Rosa, Lakshmi N Yatham, Marcia Kauer-Sant'Anna
Background: Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls. Methods: Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed...
January 30, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28334726/preparation-characterization-and-anti-ulcer-efficacy-of-sanguinarine-loaded-solid-lipid-nanoparticles
#4
Qing Sun, Weifeng Li, Huani Li, Xiumei Wang, Yu Wang, Xiaofeng Niu
AIM: This study was designed to develop sanguinarine-loaded solid lipid nanoparticles (SG-SLNs) and investigate its gastroprotective effect on ethanol-induced gastric mucosal lesions in mice. METHODS: SG-SLNs were prepared by high temperature melt-cool solidification method using glycerol monostearate as the lipid and a combination of lecithin with poloxamer 188 as the surfactants. Solid lipid nanoparticles (SLNs) were designed at varying lipid concentrations (5, 10, 15, and 20 mg/mL), surfactant mixture concentrations (6, 12, and 18 mg/mL), and drug contents (5, 10, 15, and 20 mg/mL) in "one factor at a time" fashion...
March 24, 2017: Pharmacology
https://www.readbyqxmd.com/read/28333324/novel-de-novo-mutations-of-the-interleukin-10-receptor-gene-lead-to-infantile-onset-inflammatory-bowel-disease-a-correction
#5
Kaleemuddin Mohammed, Noor Ahmad Shaik, Fahad Ahmed Al-Abbasi
No abstract text is available yet for this article.
March 15, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28333195/genome-wide-genetic-analyses-highlight-mitogen-activated-protein-kinase-mapk-signaling-in-the-pathogenesis-of-endometriosis
#6
Outi Uimari, Nilufer Rahmioglu, Dale R Nyholt, Katy Vincent, Stacey A Missmer, Christian Becker, Andrew P Morris, Grant W Montgomery, Krina T Zondervan
STUDY QUESTION: Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? SUMMARY ANSWER: GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated protein kinase (MAPK)-related pathways...
February 9, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332780/differentiation-of-patented-crystalline-glucosamine-sulfate-from-other-glucosamine-preparations-will-optimize-osteoarthritis-treatment
#7
REVIEW
Sukit Saengnipanthkul, Saranatra Waikakul, Sattaya Rojanasthien, Kitti Totemchokchyakarn, Attarit Srinkapaibulaya, Tai Cheh Chin, Nguyen Mai Hong, Olivier Bruyère, Cyrus Cooper, Jean-Yves Reginster, Myat Lwin
Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulfate (pCGS) formulation (Mylan). Glucosamine is widely available as glucosamine sulfate (GS) and glucosamine hydrochloride (GH) preparations that vary substantially in molecular form, pharmaceutical formulation and dose regimen...
March 23, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28332776/interferon-gamma-and-interleukin-10-polymorphisms-in-chinese-children-with-hemophagocytic-lymphohistiocytosis
#8
Qi An, Shao-Yan Hu, Cheng-Min Xuan, Ming-Wei Jin, Qiang Ji, Yi Wang
AIM: The aim of the study is to investigate the association of interferon gamma (IFN-γ) and interleukin-10 (IL-10) gene single nucleotide polymorphisms with the susceptibility of hemophagocytic lymphohistiocytosis (HLH) in Chinese children without known family history of HLH. PROCEDURE: Forty children with HLH and 160 age- and gender-matched healthy controls from Xuzhou Children's Hospital were enrolled in the study. Serum IFN-γ and IL-10 levels were measured by enzyme linked-immunosorbent assay...
March 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28332191/combined-application-of-er-yag-and-nd-yag-lasers-in-treatment-of-chronic-periodontitis-a-split-mouth-single-blind-randomized-controlled-trial
#9
M Sağlam, S Köseoğlu, I Taşdemir, H Erbak Yılmaz, L Savran, R Sütçü
BACKGROUND: The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planing with hand instruments in non-surgical treatment of chronic periodontitis. MATERIAL AND METHODS: Twenty-five systemically healthy patients with chronic periodontitis were selected for this study. The quadrants were randomly allocated in a split-mouth design to either combined Er:YAG (160 mJ/pulse, 10 Hz) and Nd:YAG laser (100 mJ/pulse, 20 Hz) therapy (test group) or scaling and root planing alone (control group)...
March 23, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28332085/low-level-arsenic-causes-chronic-inflammation-and-suppresses-expression-of-phagocytic-receptors
#10
Priyanka Prasad, Dona Sinha
The impact of chronic low-level groundwater arsenic (As) exposure [in the range above the WHO-recommended limit of 10 g/L but ≤50 μg/L (permissible limit of As for many Asian countries)] was investigated for cross talk of inflammatory changes and expression of phagocytic receptors of exposed rural women (N, 45) from districts of 24 Parganas (south) and in matched control groups (N, 43) [As ≤10 μg/L] from the same district. Systemic inflammation was evident from the upregulated levels of pro-inflammatory mediators like tumor necrosis factor-α (TNF-α); interleukins (ILs) like IL-6, IL-8, and IL-12; and C-reactive protein (CRP) in the sera and upregulated expression of protein kinase B phosphorylated at ser473 (pAKTser473)/nuclear factor-κB (NF-κB)/TNF-α axis in the leukocytes of exposed women with respect to control...
March 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28331165/tim-3-and-pd-1-regulate-cd8-t-cell-function-to-maintain-early-pregnancy-in-mice
#11
Yuan-Yuan Xu, Song-Cun Wang, Yi-Kong Lin, Da-Jin Li, Mei-Rong DU
During pregnancy, CD8(+) T cells are important regulators in the balance of fetal tolerance and antiviral immunity. T-cell immunoglobulin mucin-3 (Tim-3) and programmed cell death-1 (PD-1) are well-recognized negative co-stimulatory molecules involved in viral persistence and tumor metastasis. Here, we demonstrate that CD8(+) T cells co-expressing Tim-3 and PD-1 were down-regulated in the deciduae of female mice in abortion-prone matings compared with normal pregnant mice. In addition to their reduced numbers, the Tim-3(+)PD-1(+)CD8(+) T cells produced lower levels of the anti-inflammatory cytokines interleukin (IL)-4 and IL-10, as well as a higher level of the pro-inflammatory cytokine interferon (IFN)-γ, relative to those from normal pregnancy...
March 23, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28330867/influenza-vaccines-differentially-regulate-the-interferon-response-in-human-dendritic-cell-subsets
#12
Shruti Athale, Romain Banchereau, LuAnn Thompson-Snipes, Yuanyuan Wang, Karolina Palucka, Virginia Pascual, Jacques Banchereau
Human dendritic cells (DCs) play a fundamental role in the initiation of long-term adaptive immunity during vaccination against influenza. Understanding the early response of human DCs to vaccine exposure is thus essential to determine the nature and magnitude of maturation signals that have been shown to strongly correlate with vaccine effectiveness. In 2009, the H1N1 influenza epidemics fostered the commercialization of the nonadjuvanted monovalent H1N1 California vaccine (MIV-09) to complement the existing nonadjuvanted trivalent Fluzone 2009-2010 vaccine (TIV-09)...
March 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28330786/investigating-acetaminophen-hepatotoxicity-in-multi-cellular-organotypic-liver-models
#13
Sophia M Orbach, Margaret E Cassin, Marion F Ehrich, Padmavathy Rajagopalan
In vivo studies clearly demonstrate the participation and subsequent death of non-parenchymal liver cells (NPCs) with corresponding hepatocyte effects. This results in a critical need to investigate how major liver cell types function cohesively during hepatotoxicity. However, virtually no studies replicate these phenomena in vitro. We report the design of multi-cellular three-dimensional (3D) organotypic liver models of primary rat hepatocytes, liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs)...
March 19, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28330721/changes-in-the-human-transcriptome-upon-vitamin-d-supplementation
#14
Yvonne Pasing, Christopher Graham Fenton, Rolf Jorde, Ruth Hracky Paulssen
Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). The VDR is present in a wide variety of different cells types and tissues and acts as a transcription factor. Although activation of the VDR is estimated to regulate expression of up to 5% of the human genome, our study is the first analysing gene expression after supplementation in more than 10 subjects. Subjects of a randomized controlled trial (RCT) received either vitamin D3 (n47) in a weekly dose of 20,000 IU or placebo (n 47) for a period of three to five years...
March 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28330599/impact-of-graft-preservation-solutions-for-liver-transplantation-on-early-cytokine-release-and-postoperative-organ-dysfunctions-a-pilot-study
#15
H Brisson, C Arbelot, A Monsel, C Parisot, M Girard, E Savier, C Vezinet, Q Lu, J-C Vaillant, J-L Golmard, G Gorochov, O Langeron, J-J Rouby
INTRODUCTION: During liver transplantation, graft ischemia-reperfusion injury leads to a systemic inflammatory response producing postoperative organ dysfunctions. The aim of this observational and prospective study was to compare the impact of Solution de conservation des organes et tissus (SCOT) 15 and University of Wisconsin (UW) preservation solutions on early cytokine release, postreperfusion syndrome and postoperative organ dysfunctions. METHODS: Thirty-seven liver transplantations were included: 21 in UW Group and 16 in SCOT 15 group...
March 15, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28330430/effect-of-waterpipe-tobacco-smoking-on-airway-inflammation-in-murine-model-of-asthma
#16
Nour A Al-Sawalha, Ala'a M Migdadi, Karem H Alzoubi, Omar F Khabour, Nidal A Qinna
OBJECTIVE: There has been an increase in the popularity of waterpipe tobacco smoking (WTS) worldwide, especially in the younger population, including asthma patients. In this study, we investigated the effects of waterpipe smoking on airway inflammation, cytokine levels and oxidative stress markers in an antigen-driven murine model of asthma. MATERIALS AND METHODS: Balb/c mice were divided into four groups; (1) control (received fresh air, ovalbumin sensitization and saline challenge), (2) WTS (received WTS, ovalbumin sensitization and saline challenge), (3) Ova S/C (received fresh air, ovalbumin sensitization and ovalbumin challenge) and (4) simultaneous WTS and Ova S/C (received WTS, ovalbumin sensitization and ovalbumin challenge)...
February 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28329704/the-ifn-%C3%AE-ifn-%C3%AE-r1-il-10r%C3%AE-complex-reveals-structural-features-underlying-type-iii-ifn-functional-plasticity
#17
Juan L Mendoza, William M Schneider, Hans-Heinrich Hoffmann, Koen Vercauteren, Kevin M Jude, Anming Xiong, Ignacio Moraga, Tim M Horton, Jeffrey S Glenn, Ype P de Jong, Charles M Rice, K Christopher Garcia
Type III interferons (IFN-λs) signal through a heterodimeric receptor complex composed of the IFN-λR1 subunit, specific for IFN-λs, and interleukin-10Rβ (IL-10Rβ), which is shared by multiple cytokines in the IL-10 superfamily. Low affinity of IL-10Rβ for cytokines has impeded efforts aimed at crystallizing cytokine-receptor complexes. We used yeast surface display to engineer a higher-affinity IFN-λ variant, H11, which enabled crystallization of the ternary complex. The structure revealed that IL-10Rβ uses a network of tyrosine residues as hydrophobic anchor points to engage IL-10 family cytokines that present complementary hydrophobic binding patches, explaining its role as both a cross-reactive but cytokine-specific receptor...
March 21, 2017: Immunity
https://www.readbyqxmd.com/read/28329134/dynapenic-abdominal-obesity-as-a-predictor-of-worsening-disability-hospitalization-and-mortality-in-older-adults-results-from-the-inchianti-study
#18
Andrea P Rossi, Lara Bianchi, Stefano Volpato, Stefania Bandinelli, Jack Guralnik, Mauro Zamboni, Luigi Ferrucci
Background: There are relatively few prospective studies evaluating the combined effect of abdominal obesity and low muscle strength on mortality, hospitalization, and incident disability. The aim of this study was to prospectively evaluate the prognostic value of dynapenic abdominal obesity on incident disability, hospitalization, and mortality in the population of the InCHIANTI study. Methods: In 370 men and 476 women aged between 65 and 95 years, handgrip strength, waist circumference (WC), body mass index, interleukin-6, C-reactive protein, education, medications, smoking status, and comorbidities were evaluated at the baseline...
March 8, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329022/annexin-a1-in-blood-mononuclear-cells-from-patients-with-coronary-artery-disease-its-association-with-inflammatory-status-and-glucocorticoid-sensitivity
#19
Ida Bergström, Anna K Lundberg, Simon Jönsson, Eva Särndahl, Jan Ernerudh, Lena Jonasson
Annexin A1 (AnxA1) is a key player in resolution of inflammation and a mediator of glucocorticoid actions. In atherosclerotic tissue, increased expression of AnxA1 has been associated with protective plaque-stabilizing effects. Here, we investigated the expression of AnxA1 in peripheral blood mononuclear cells (PBMCs) from patients with coronary artery disease (CAD). Blood was collected from 57 patients with stable CAD (SCAD) and 41 healthy controls. We also included a minor group (n = 10) with acute coronary syndrome (ACS)...
2017: PloS One
https://www.readbyqxmd.com/read/28328867/astragaloside-iv-alleviates-lipopolysaccharide-induced-acute-kidney-injury-through-down-regulating-cytokines-ccr5-and-p-erk-and-elevating-anti-oxidative-ability
#20
Wei Zhou, Yi Chen, Xingyu Zhang
BACKGROUND Astragaloside IV (AS-IV) has been shown to prevent ischemia-induced acute kidney injury (AKI) in rat models of ischemia and reperfusion. However, the effects of AS-IV on AKI during sepsis and endotoxinemia is unclear. The current study aimed to investigate the effects and molecular mechanisms of AS-IV on lipopolysaccharide (LPS)-induced AKI. MATERIAL AND METHODS Adult male CD-1 mice were randomly assigned into 6 groups (n=8/group): control group: mice were intraperitoneally (i.p.) injected with normal saline; LPS group (10 mg/kg, i...
March 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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