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https://www.readbyqxmd.com/read/28821194/primary-benign-and-malignant-thyroid-neoplasms-with-signet-ring-cells-cytologic-histologic-and-molecular-features
#1
Nada A Farhat, Ayse M Onenerk, Jeffrey F Krane, Dora Dias-Santagata, Peter M Sadow, William C Faquin
Objectives: Signet ring cells (SRCs) can be seen in a variety of thyroid tumors and can pose a diagnostic pitfall on cytology. This study describes the cytologic, histomorphologic, and molecular aspects of a cohort of primary thyroid tumors with SRCs. Methods: A search was performed of the Massachusetts General Hospital and Brigham and Women's Hospital (Boston, MA) pathology archives for the keywords thyroid, signet, and signet ring features between 2000 and 2014...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821191/impact-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-features-on-adequacy-criteria-and-risk-of-malignancy-of-thyroid-fine-needle-aspiration
#2
Andrew A Renshaw, Edwin W Gould
Objectives: The impact of noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP) on nondiagnostic and benign diagnoses is not well characterized. Methods: The results of all thyroid fine-needle aspirates (FNAs) performed from 1997 to June 2016 with corresponding resections were reviewed. Results: From 12,764 aspirates, there were 8,106 (64%) benign diagnoses with 412 (5%) resections and 1,888 (14.8%) nondiagnostic diagnoses with 329 (17%) resections...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821190/fibromatosis-of-the-breast-diagnostic-accuracy-of-core-needle-biopsy
#3
M Gabriela Kuba, Susan C Lester, Catherine S Giess, Monica M Bertagnolli, Tad J Wieczorek, Jane E Brock
Objectives: Fibromatosis of the breast is an uncommon neoplasm with potential for local recurrence. Treatment has traditionally been surgical excision with current trends toward conservative management. Given the option of observation after diagnosis by core needle biopsy (CNB), we sought to evaluate the accuracy of CNB for diagnosing fibromatosis. Methods: We identified a total of 31 cases in which fibromatosis had been diagnosed or included in the differential diagnosis on a CNB, an excision, or both...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820165/extraocular-needle-guided-haptic-insertion-technique-of-scleral-fixation-intraocular-lens-surgeries-x-nit
#4
Prabu Baskaran, Pratyusha Ganne, Sahil Bhandari, Seema Ramakrishnan, Rengaraj Venkatesh, Prashant Gireesh
The most challenging step in sutureless scleral fixation of intraocular lens (SFIOL) is exteriorization of haptics. The conventional handshake technique has a learning curve since it involves intraocular handing over of haptics from one forceps to another. Here, we describe "extraocular needle-guided haptic insertion technique" (X-NIT), a novel technique of exteriorizing haptics that totally eliminates intraocular manipulations. This method involves sequential introduction of two bent 26-gauge needles through the sclera (pars plicata zone) into the eye which are brought out through a sclerocorneal wound...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28819950/successful-eus-guided-ethanol-ablation-of-insulinoma-four-year-follow-up-case-report-and-literature-review
#5
Krzysztof Dąbkowski, Paula Gajewska, Kamila Walter, Magdalena Londzin-Olesik, Andrzej Białek, Elżbieta Andrysiak-Mammos, Beata Kos-Kudła, Teresa Starzyńska
INTRODUCTION: EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour. Ablation is recommended in patients who are poor surgical candidates or refuse surgery. We present a case of an 81-year-old female with symptomatic insulinoma, treated successfully with EUS-guided alcoholic ablation, along with a literature review including 28 other previously described cases. The effectiveness, safety of the therapy, and technical procedure-related issues are summarised...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28819755/importance-of-fna-technique-for-decreasing-non-diagnostic-rates-in-thyroid-nodules
#6
Amarbir S Gill, Richard Amdur, Arjun S Joshi
To identify potential interventions that may lower the high non-diagnostic rates associated with ultrasound guided (US) fine needle aspiration (FNA) biopsy of the thyroid nodule. A case series of 164 thyroid nodule US-guided FNA was identified retrospectively. The following variables were analyzed in regards to diagnostic and non-diagnostic sampling: patient age, gender, size of nodule, biopsy technique (capillary vs. aspiration), needle gauge (23 vs. 25), and physician experience. The FNA diagnosis, and final pathology, when applicable, was recorded for each sample using the Bethesda criteria...
August 17, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28819609/combined-fluoroscopic-and-arthroscopic-detection-and-removal-of-a-foreign-body-lost-during-elective-shoulder-arthroscopy-a-case-report
#7
Uli Schmiddem, N Hawi, E M Suero, R Meller
INTRODUCTION: We report a case of a lost metal platelet from a radiofrequency ablation probe (VAPR VUE Radiofrequency System, Cool Pulse 90, DePuy, Synthes, Switzerland) in the shoulder joint during elective arthroscopic cuff repair. To the best of our knowledge, this kind of an incident during elective arthroscopy has not been described in the literature so far. In addition, we present an algorithm on how to deal with such an incident. CASE REPORT: A 69-year-old woman underwent an arthroscopic subacromial decompression and rotator cuff repair for a torn supraspinatus tendon...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28819449/self-assembly-dna-polyplex-vaccine-inside-dissolving-microneedles-for-high-potency-intradermal-vaccination
#8
Jing-Fong Liao, Jin-Ching Lee, Chun-Kuang Lin, Kuo-Chen Wei, Pin-Yuan Chen, Hung-Wei Yang
The strong immunogenicity induction is the powerful weapon to prevent the virus infections. This study demonstrated that one-step synthesis of DNA polyplex vaccine in microneedle (MN) patches can induce high immunogenicity through intradermal vaccination and increase the vaccine stability for storage outside the cold chain. More negative charged DNA vaccine was entrapped into the needle region of MNs followed by DNA polyplex formation with branched polyethylenimine (bPEI) pre-coated in the cavities of polydimethylsiloxane (PDMS) molds that can deliver more DNA vaccine to immune-cell rich epidermis with high transfection efficiency...
2017: Theranostics
https://www.readbyqxmd.com/read/28819424/circulating-tumor-cells-and-microemboli-can-differentiate-malignant-and-benign-pulmonary-lesions
#9
Mario Mascalchi, Cristina Maddau, Lapo Sali, Elena Bertelli, Francesca Salvianti, Stefania Zuccherelli, Marzia Matucci, Alessandra Borgheresi, Claudio Raspanti, Monica Lanzetta, Massimo Falchini, Ernesto Mazza, Alessandra Vella, Michaela Luconi, Pamela Pinzani, Mario Pazzagli
The presence of circulating tumor cells (CTC) or microemboli (CTM) in the peripheral blood can theoretically anticipate malignancy of solid lesions in a variety of organs. We aimed to preliminarily assess this capability in patients with pulmonary lesions of suspected malignant nature. We used a cell-size filtration method (ScreenCell) and cytomorphometric criteria to detect CTC/CTM in a 3 mL sample of peripheral blood that was taken just before diagnostic percutaneous CT-guided fine needle aspiration (FNA) or core biopsy of the suspicious lung lesion...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819382/effectiveness-of-the-benign-and-malignant-diagnosis-of-mediastinal-and-hilar-lymph-nodes-by-endobronchial-ultrasound-elastography
#10
Haidong Huang, Zhiang Huang, Qin Wang, Xinan Wang, Yuchao Dong, Wei Zhang, Paul Zarogoulidis, Yan-Gao Man, Wolfgang Hohenforst Schmidt, Chong Bai
Background and Objectives: Endobronchial ultrasound elastography is a new technique for describing the stiffness of tissue during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The aims of this study were to investigate the diagnostic value of Endobronchial ultrasound (EBUS) elastography for distinguishing the difference between benign and malignant lymph nodes among mediastinal and hilar lymph node. Materials and Methods: From June 2015 to August 2015, 47 patients confirmed of mediastinal and hilar lymph node enlargement through examination of Computed tomography (CT) were enrolled, and a total of 78 lymph nodes were evaluated by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819052/dolphin-blubber-axial-muscle-shear-implications-for-rigid-trans-dermal-intra-muscular-tracking-tag-trauma-in-whales
#11
Michael J Moore, Alexandre N Zerbini
Whale tracking tags often penetrate semi-rigid blubber, with intramuscular sharp tips and toggling barbs under the subdermal sheath to reduce premature shedding. Tag sites can show persistent regional swellings or depressions. Fibroelastic blubber grips a tag, so if muscle shears relative to blubber during locomotion, the tag tip could cavitate the muscle within overall shearing distance. We modelled shearing of blubber relative to muscle, within the dorsal-ventral peduncular movement range of four common dolphin (Delphinus delphis) cadavers (mean length 186 cm)...
August 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28818701/lapcap-a-novel-device-to-reduce-the-entry-complications
#12
Ramesh Bettaiah, Shwetha Sudhakar Kamath, Rachana Ghanti
Laparoscopy is one of the most common procedures performed worldwide .Over 50% of laparoscopic injuries to the gastrointestinal tract and major vessels occur during the initial entry phase. Major vascular injury during the initiation of a pneumoperitoneum is a much feared complication of laparoscopic procedures.This can be overcome by using a vacuum cup at the time of Veress entry especially in thin patients.The vacuum cup is a simple device to create pneumoperitoneum with ease . It can significantly reduce the risk of retroperitoneal injury associated with the use of Veress needle...
August 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28818480/-infection-control-practices-while-performing-prostate-biopsies-in-france-a-ciafu-survey
#13
P Leduc, J D Doublet, F Bruyère, S Malavaud
In 2008, the French Public Health Committee admitted that associating ultrasound probe protection, and related precautions, and low-level disinfection would be equivalent to the intermediate level disinfection. In 2010, the French Urology Association (AFU) updated guidelines regarding trans-rectal prostate biopsies, namely preventive measures related to cross-transmission of infections. We report an evaluation of compliance to them, driven in 2016 by AFU's infection committee. Although not recommended, almost one third of the urologists still perform biopsies under general anesthesia, and two thirds of them ask for a urine culture before biopsies...
August 14, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28817880/re-formalin-disinfection-of-prostate-biopsy-needles-may-reduce-post-biopsy-infectious-complications
#14
Edward M Schaeffer
No abstract text is available yet for this article.
September 2017: Journal of Urology
https://www.readbyqxmd.com/read/28817072/efficient-transdermal-delivery-of-alendronate-a-nitrogen-containing-bisphosphonate-using-tip-loaded-self-dissolving-microneedle-arrays-for-the-treatment-of-osteoporosis
#15
Hidemasa Katsumi, Yutaro Tanaka, Kaori Hitomi, Shu Liu, Ying-Shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). We observed micron-scale pores in rat skin just after application of ALN(TIP)-MN, indicating that transdermal pathways for ALN were created by MN. ALN was rapidly released from the tip of MNs as observed in an in vitro release study...
August 17, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28816971/combining-of-serial-embolization-and-denosumab-for-large-sacropelvic-giant-cell-tumor-case-report-of-3-cases
#16
Tao Ji, Yi Yang, Yifei Wang, Kunkun Sun, Wei Guo
RATIONALE: Both serial arterial embolization (SAE) and denosumab have been proved to be effective in treatment for giant cell tumor (GCT). There is potential synergic effect of combining two methods. The purpose of current study is to justify a new treatment strategy of combination of SAE and denosumab as neoadjuvant or stand-alone treatment for large sacropelvic giant cell tumor. PATIENT CONCERNS: Pelvic and sacral GCTs tend to be very large size and vascular. The concerns of surgical treatment were invasiveness of extensive surgery, intraoperative hemorrhage, nerve function jeopardized and local recurrence...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816765/the-needle-or-knife-pegloticase-for-refractory-crippling-gout-in-a-nonagenarian
#17
Noah Choi, Jeffrey Eickhoff, Michael Keith
No abstract text is available yet for this article.
August 14, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28816720/racial-inequities-in-hiv-prevalence-and-composition-of-risk-networks-among-people-who-inject-drugs-in-hptn-037
#18
Florence Momplaisir, Mustafa Hussein, Danielle Tobin-Fiore, Laramie Smith, David Bennett, Carl Latkin, David S Metzger
BACKGROUND: HIV prevention interventions in the U.S. have failed to eliminate racial inequities. Here, we evaluate factors associated with racial inequities in HIV prevalence among people who inject drugs (PWID) using HIV Prevention Trial Network 037 data. METHODS: We measured racial homophily (i.e., all members share the same race), being in an HIV+ network (network with ≥ 1 HIV+ member) and drug and sex risk behaviors. A two-level logistic regression with a random intercept evaluated the association between being in an HIV+ network and race adjusting for individual and network-level factors...
August 12, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28816309/reply-to-the-comment-on-towards-a-personalized-approach-to-aromatase-inhibitor-therapy-a-digital-microfluidic-platform-for-rapid-analysis-of-estradiol-in-core-needle-biopsies-by-p-e-l%C3%A3-nning-lab-chip-2017-17-doi-10-1039-c7lc00617a
#19
Robert F Casper, Aaron R Wheeler
This article provides our response to a comment on our article that appeared in Lab on a Chip (S. Abdulwahab, A. H. C. Ng, M. D. Chamberlain, H. Ahmado, L.-A. Behan, H. Gomaa, R. F. Casper and A. R. Wheeler, Lab Chip, 2017, 17, 1594).
August 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28816306/comment-on-towards-a-personalized-approach-to-aromatase-inhibitor-therapy-a-digital-microfluidic-platform-for-rapid-analysis-of-estradiol-in-core-needle-biopsies-by-s-abdulwahab-a-h-c-ng-m-d-chamberlain-h-ahmado-l-a-behan-h-gomaa-r-f-casper-and-a-r-wheeler
#20
Per E Lønning
This comment on an article that appeared in Lab on a Chip (Abdulwahab et al., Lab Chip, 2017, 17, 1594) highlights the need for further validation of the proposed method.
August 17, 2017: Lab on a Chip
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