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https://www.readbyqxmd.com/read/29346358/rates-of-unsuspected-thyroid-cancer-in-multinodular-thyroid-disease
#1
Miriam Karalus, Jade Au Tamatea, Helen M Conaglen, Goswin Y Meyer-Rochow, John V Conaglen, Marianne S Elston
BACKGROUND: Previously the risk of concomitant thyroid cancer in multinodular goitre (MNG) has been reported as approximately 4%. Cancer risk in toxic MNG was often considered lower than for non-toxic MNG, due to a possible protective effect of TSH suppression. However, recent American data suggest an approximately 18% risk of occult malignancy in both toxic and non-toxic MNG. AIMS: To assess malignancy risk in a New Zealand population undergoing thyroidectomy for MNG...
January 19, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29346252/sarcoidosis-with-pleural-effusion-as-the-presenting-symptom
#2
Estefania Rivera, Yaron Gesthalter, Paul Vardelaan, Alex Chee, Adnan Majid
A 65-year-old woman, never smoker, with medical history of hypertension, nonischemic cardiomyopathy, and moderate pulmonary hypertension presented with symptomatic bilateral pleural effusions. Thoracentesis revealed a lymphocyte predominant transudate and was negative for malignancy, microbiologic cultures were negative for an infectious cause. Chest tomography showed mediastinal and bilateral hilar lymphadenopathy, lymph node biopsy with endobronchial ultrasound-guided transbronchial needle aspiration showed non-necrotizing granulomas compatible with sarcoidosis...
January 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29346251/combined-endosonography-reduces-time-to-diagnose-pulmonary-coccidioidomycosis
#3
Raj A Shah, Jose J Vempilly, Shaikh M Noor Ul Husnain, Pravachan Hegde
Coccidioidomycosis causes significant morbidity in endemic areas. In the absence of sensitive diagnostic serologic testing, clinicians have increasingly relied on lung and lymph node biopsies for diagnosis. Recently, endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been shown to be an excellent sampling method for the diagnosis and staging of lung cancers, especially when combined with endoscopic ultrasound guided fine needle aspiration (EUS-FNA). We present 13 consecutive cases where EBUS-TBNA and/or EUS-FNA of pulmonary lymph nodes were performed as part of the workup for pulmonary coccidioidomycosis...
January 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29346217/pathological-and-molecular-aspects-to-improve-endoscopic-ultrasonography-guided-fine-needle-aspiration-from-solid-pancreatic-lesions
#4
Hiroyuki Matsubayashi, Keiko Sasaki, Sachiyo Ono, Masato Abe, Hirotoshi Ishiwatari, Akira Fukutomi, Katsuhiko Uesaka, Hiroyuki Ono
Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been applied to pancreatic lesions since the 1990s, and its use is now widespread. Improvements in endoscopic devices and sampling techniques have resulted in excellent diagnostic ability for solid pancreatic lesions. However, clinical improvements alone are not responsible for it; pathological aspects have also played important roles. Rapid on-site evaluation minimizes endoscopic procedures, although its value at improving the diagnostic ratio is still debated...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29346046/ultrasonographic-characteristics-of-the-reproductive-tract-and-serum-progesterone-and-estradiol-concentrations-in-captive-female-red-wolves-canis-rufus-with-and-without-reproductive-tract-disease
#5
Kadie M Anderson, Mandi W Schook, Karen L Goodrowe, William T Waddell, Karen N Wolf
OBJECTIVE To describe ultrasonographic characteristics of the reproductive tract and serum progesterone and estradiol concentrations in captive female red wolves (Canis rufus) with and without reproductive tract disease. DESIGN Prospective study. ANIMALS 13 adult female red wolves. PROCEDURES Wolves with varying parity and history of contraceptive treatment were anesthetized to facilitate ultrasonographic examination and measurement of the reproductive tract and blood collection for determination of serum progesterone and estradiol concentrations in December 2011 and June 2012...
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29345728/analytical-performance-of-the-thyroseq-v3-genomic-classifier-for-cancer-diagnosis-in-thyroid-nodules
#6
Marina N Nikiforova, Stephanie Mercurio, Abigail I Wald, Michelle Barbi de Moura, Keith Callenberg, Lucas Santana-Santos, William E Gooding, Linwah Yip, Robert L Ferris, Yuri E Nikiforov
BACKGROUND: Molecular tests have clinical utility for thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology, although their performance requires further improvement. This study evaluated the analytical performance of the newly created ThyroSeq v3 test. METHODS: ThyroSeq v3 is a DNA- and RNA-based next-generation sequencing assay that analyzes 112 genes for a variety of genetic alterations, including point mutations, insertions/deletions, gene fusions, copy number alterations, and abnormal gene expression, and it uses a genomic classifier (GC) to separate malignant lesions from benign lesions...
January 18, 2018: Cancer
https://www.readbyqxmd.com/read/29345016/evaluation-of-the-implementation-of-a-24-hour-stroke-thrombolysis-emergency-treatment-for-patients-with-acute-ischemic-stroke
#7
Jun Zhao, Xingqiang Li, Yingchun Liang, Liang Zhao, Xinping Zhang, Yunlin Liu
AIMS AND OBJECTIVES: To assess the trends of intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (rt-PA) among patients with acute ischemic stroke (AIS) admitted to our hospital between 2012 and 2014 and investigate the effects of a 24-hours (h) stroke thrombolysis emergency treatment on the intra-hospital clinical data and outcomes of these patients treated with IV rt-PA thrombolysis. BACKGROUND: Although pre-notification of stroke by emergency medical services have been endorsed by the national recommendations and implemented in some developed countries, the development in China is limited...
January 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29344911/recurrent-infectious-subcapsular-renal-hematoma-accompanied-by-microaneurysm
#8
Toshikazu Ozeki, Junichiro Yamamoto, Shigeki Yamamoto, Chisato Shigematsu, Masashi Tsuji
An 80-year-old woman was admitted to the hospital complaining of loss of appetite. 10 days earlier, her oral intake gradually decreased with no other specific symptoms, such as abdominal pain, nausea, vomiting, headache, or low back pain. Abdominal computed tomography (CT) scan revealed a left subcapsular renal hematoma. We suspected infective subcapsular renal hematoma, so percutaneous needle aspiration and drainage were performed. Intravenous sulbactam-ampicillin was started immediately. On day 9 after admission, repeat CT scan revealed the subcapsular hematoma had reduced in size...
January 17, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29344699/feasibility-study-of-mr-guided-transgluteal-targeted-in-bore-biopsy-for-suspicious-lesions-of-the-prostate-at-3-tesla-using-a-freehand-approach
#9
Frank Fischbach, Lukas Wien, Sascha Krueger, Bernhard Schnackenburg, Daniel Baumunk, Björn Friebe, Martin Schostak, Jens Ricke, Katharina Fischbach
OBJECTIVE: The aim of our study was (1) to establish an in-bore targeted biopsy of suspicious prostate lesions, avoiding bowel penetration using a transgluteal approach and (2) to assess operator setup, patient comfort and safety aspects in the clinical setting for freehand real-time MR-guidance established for percutaneous procedures in an open MR-scanner. MATERIAL AND METHODS: 30 patients with suspect prostate lesions were biopsied in a cylindrical 3T-MRI system using a transgluteal approach in freehand technique...
January 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29344564/endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-in-solid-pancreatic-masses-a-prospective-validation-study
#10
John Gásdal Karstensen, Tatiana Cârţână, Codruţa Constantinescu, Silviu Dumitrașcu, Bojan Kovacevic, Pia Klausen, Hazem Hassan, Tobias Wirenfeldt Klausen, Helga Bertani, Manoop S Bhutani, Adrian Săftoiu, Peter Vilmann
Background and study aims:  Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is a keystone in diagnosing and staging of pancreatic masses. Recently, a microfiber that can pass through a 19-gauge needle has been introduced for confocal laser endomicroscopy (nCLE). The aims of this study were to evaluate the diagnostic value and the reproducibility of nCLE criteria for solid malignant lesions. Patients and methods:  This prospective dual-center study included patients with pancreatic masses suspicious of malignancy referred for EUS-FNA...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29344493/comparison-of-gene-expression-profiling-and-chromosome-3-analysis-by-fluorescent-in-situ-hybridization-and-multiplex-ligation-probe-amplification-in-fine-needle-aspiration-biopsy-specimens-of-uveal-melanoma
#11
Michael A Klufas, Elizabeth Richter, Sujit Itty, Christian Moreno, Colin A McCannel, Tara A McCannel
Purpose: The aim of this paper was to assess the concordance between results of DecisionDx-UM specific gene expression profiling (GEP) and fluorescence in situ hybridization (FISH) for chromosome 3 analysis, and between DecisionDx-UM GEP and multiplex ligation probe amplification (MLPA) in uveal melanoma undergoing intraoperative fine-needle aspiration biopsy (FNAB) for metastatic prognostication during brachytherapy. Methods: We retrospectively reviewed consecutive patients diagnosed with posterior uveal melanoma who underwent intraoperative FNAB prior to placement of an iodine-125 radioactive plaque between 2012 and 2014...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344047/a-comparative-study-of-shift-work-effects-and-injuries-among-nurses-working-in-rotating-night-and-day-shifts-in-a-tertiary-care-hospital-of-north-india
#12
Anjana Verma, Jugal Kishore, Shobha Gusain
Background: Shift work can have an impact on the physical and psychological well-being of the healthcare worker, affecting patients as well as their own safety at the workplace. This study was conducted to compare the health outcomes and injuries, along with associated risk factors between the nurses working in rotating night shift (RNS) as compared to day shift (DS) only. Materials and Methods: It was a cross-sectional study conducted from June to November 2016 in a tertiary care hospital of Delhi...
January 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29343981/assessment-of-pain-score-and-specimen-adequacy-for-ultrasound-guided-fine-needle-aspiration-biopsy-of-thyroid-nodules
#13
Li-Jen Liao, Wu-Chia Lo, Wan-Lun Hsu, Po-Wen Cheng, Cheng-Ping Wang
Objective: The aim of this study was to evaluate pain scores and specimen adequacy for ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules without and with local anesthesia (LA). Materials and methods: The US-FNAB procedure was performed on 183 patients with and without LA. One puncture was made for solid nodules, and if patients could tolerate it, a two-puncture technique was used for nodules with a cystic change. Four-point verbal rating scores were assessed by a nursing assistant after completion of US-FNAB...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29343693/phantom-acupuncture-induces-placebo-credibility-and-vicarious-sensations-a-parallel-fmri-study-of-low-back-pain-patients
#14
Meena M Makary, Jeungchan Lee, Eunyoung Lee, Seulgi Eun, Jieun Kim, Geon-Ho Jahng, Kiok Kim, You-Suk Youn, Jun-Hwan Lee, Kyungmo Park
Although acupuncture is an effective therapeutic intervention for pain reduction, the exact difference between real and sham acupuncture has not been clearly understood because a somatosensory tactile component is commonly included in the existing sham acupuncture protocols. In an event-related fMRI experiment, we implemented a novel form of sham acupuncture, phantom acupuncture, that reproduces the acupuncture needling procedure without somatosensory tactile stimulation while maintaining the credibility of the acupuncture treatment context...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343617/methods-to-determine-the-silicone-oil-layer-thickness-in-sprayed-on-siliconized-syringes
#15
Viviane Loosli, Oliver Germershaus, Henrik Steinberg, Sascha Dreher, Ulla Grauschopf, Stefanie Funke
The silicone lubricant layer in prefilled syringes (PFS) has been investigated with regards to siliconization process performance, PFS functionality and drug product attributes such as subvisible particle levels in several studies in the past. However, adequate methods to characterize the silicone oil layer thickness and -distribution are limited and systematic evaluation is missing. In this study, white light interferometry (WLI) was evaluated to close this gap in method understanding. WLI demonstrated a good accuracy of 93-99 % for MgF2 coated, curved standards covering a thickness range of 115-473 nm...
January 17, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29343303/comparison-of-modified-wet-suction-technique-and-dry-suction-technique-in-endoscopic-ultrasound-guided-fine-needle-aspiration-eus-fna-for-solid-lesions-study-protocol-for-a-randomized-controlled-trial
#16
Yun Wang, Qian Chen, Jinlin Wang, Xiaoli Wu, Yaqi Duan, Ping Yin, Qiaozhen Guo, Wei Hou, Bin Cheng
BACKGROUND: Several suction techniques have been developed recently to enhance tissue acquisition when sampling solid lesions using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The aim of this study is to determine whether a new modified wet suction technique (MWST) compared with the conventional dry suction technique (DRST) shall present better outcomes with respect to diagnostic yield and specimen quality of solid lesions in the intra-abdomen and mediastinum. METHODS/DESIGN: This is a single-blind, randomized, controlled, superiority trial conducted at four large tertiary care centers in China...
January 17, 2018: Trials
https://www.readbyqxmd.com/read/29342951/microstructure-and-tensile-properties-of-ecaped-mg-9al-1si-1sic-composites-the-influence-of-initial-microstructures
#17
Shaoxiong Zhang, Ming Li, Hongxia Wang, Weili Cheng, Weiwei Lei, Yiming Liu, Wei Liang
Mg-9Al-1Si-1SiC composites with various initial microstructures prior to equal channel angular pressing (ECAP) were obtained by different pre-treatments (without and with homogenization treatment), and the resultant grain size, second phase and tensile properties of ECAPed composites were reported. The ECAPed composite with homogenization treatment (HT) exhibited finer grain size, higher fraction of dynamically recrystallized (DRXed) grains, weaker texture intensity, as well as the presence of dynamic precipitated Mg17Al12 phase compared to that without HT...
January 15, 2018: Materials
https://www.readbyqxmd.com/read/29341470/cytological-features-of-mixed-adenoneuroendocrine-carcinoma-of-the-ampulla-of-vater-a-case-report-with-immunocytochemical-analyses
#18
Saya Yoshioka, Yusuke Ebisu, Mitsuaki Ishida, Yoshiko Uemura, Hiroaki Yanagimoto, Sohei Satoi, Koji Tsuta
Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor that has morphologically recognizable both adenocarcinoma and neuroendocrine carcinoma components comprising at least 30% of either components. MANEC occurring in the ampulla of Vater is extremely rare, and only 16 cases have been reported in the English language literature. In the present report, we describe the first case of MANEC of the ampulla of Vater with immunocytochemical analyses. An 82-year-old Japanese male was incidentally found to have a tumorous lesion in the ampulla of Vater...
January 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29341459/multicenter-study-of-diagnostic-procedures-genetic-aberration-analysis-and-first-line-treatment-of-lung-cancer-in-jiangsu-province-china
#19
YangBo Hu, Huan Hu, LiYun Miao, Xin Zhao, Wei Gu, Wei Heng, ZiLi Meng, Jian Feng, Yi You, XingXiang Xu, Rong Hu, HaiQuan Li, Jie Zhao, XiaoLi Zhu, MeiQi Shi, Li Shen, XiuWei Zhang, XiaoWei Yin, Hang Ma, MinHua Shi, Yong Yu, Hong Lv, LiMing Cai, GaoHua Feng, YeQing Zhang, Feng Wu, TangFeng Lv, Yong Song
BACKGROUND: Jiangsu Province, China, is highly developed economically and culturally, and has a high prevalence of lung cancer. We aimed to evaluate the diagnostic procedures, genetic aberration analysis status, and first-line treatment models of lung cancer in Jiangsu Province. METHODS: Lung cancer patients diagnosed in 2016 at 22 tertiary care hospitals were evaluated. Demographic characteristics, tumor histology, staging, family history of lung cancer, auxiliary examinations, genetic testing, and first-line treatment were collected on discharge...
January 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29341164/patient-derived-organoid-models-help-define-personalized-management-of-gastrointestinal-cancer
#20
REVIEW
M R Aberle, R A Burkhart, H Tiriac, S W M Olde Damink, C H C Dejong, D A Tuveson, R M van Dam
BACKGROUND: The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies have failed to improve survival for many tumours. Although promising, the clinical application of molecularly guided personalized treatment has proven to be challenging. This narrative review focuses on the personalization of cancer therapy using patient-derived three-dimensional 'organoid' models...
January 2018: British Journal of Surgery
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