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V Ramistella, M Wasniewska, M Valenzise, D Corica, S Cantucci, E Pitrolo, M Romeo, F De Luca
UNLABELLED: Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is a rare and complex pediatric disorder. Children typically show ROHHAD after the first years of life with rapid weight gain and subsequently autonomic nervous system dysregulation (altered pain perception, pupillary dysfunction, hypothermia and bradycardia); alveolar hypoventilation with risk of cardiorespiratory arrest and hypothalamic dysfunction (central diabetes insipidus, hypothyroidism, growth hormone and corticotrophin deficiency)...
July 2013: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
T M Milojević, B V Baljozović, M Lj Rakić, B D Nestorović, M M Dostanić, B D Milaković, Z Z Kojić, N R Repac, I S Cvrkota
Cerebral vasospasm causes permanent neurolological deficit or death occurance in 13% of clinical cases. Peak frequency is from 8-10th day after SAH. The purpose of this study is factor analysis that may have influence on vasospasm development , as well as predictor determination. The study is prospective and analysis 192 patients treated in Institute of Neurosurgery, Clinical Centre of Serbia, Belgrade. The majority of patients were admitted in hospital in first four days after SAH, and 184 had GCS over 7. Univariate methods of factor analysis were used, and for significance of predictors influence testing multivariante regression analysis was used...
2008: Acta Chirurgica Iugoslavica
A I Iaroshetskiĭ, D N Protsenko, O V Ignatenko, B R Gel'fand
The paper reflects the results of a study to predict a fatal outcome in severe injury, by evaluating the condition by the APACHE II, SAPS II, MODS, SOFA, and Glasgow coma scale. Particular emphasis is laid on the assessment of the quality of an obtained prediction, by using the currently available tools--the resolving power of a prognostic model (area under the characteristic curve), choice of the prognostive value (division point), and calibration of the model. It was ascertained that the APACHE II and SAPS II scales could not significantly predict a fatal outcome in severe injury...
November 2006: Anesteziologiia i Reanimatologiia
S S Oganesian, E V Daian, M A Eloian, S M Minasian
The article presents the results of an investigation aimed at the assessment of electrolyte balance in patients who underwent surgical treatment. The data demonstrate that in the patients from the control group there was increased blood concentration of Na+ during the preoperative period that remained in the course of the postoperative one. Hypernatriemia was associated with decreased level of K+. Besides, hyposalivation that was maximal on the days immediate after an operation and reduced Na+ excretion together with increased K+ excretion were revealed...
July 2005: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
V G Amcheslavskií, N N Bragina, T A Dobrokhotova, I A Voronina, I A Savin, N A Alieva
The paper deals with the relationship of homeostatic and motivational disorders in the postoperative clinical picture in basal-diencephalic tumors. The material included 354 clinical observations of: hypophysial adenoma (n = 135); craniopharyngioma (n = 71); tumors of the third ventricle (n = 88); basal meningiomas (n = 60). A comparative analysis of the findings allowed the authors to support that there are typical variants of changes in the patients' status, which reflect the nature of ion-osmotic disorders...
April 2002: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
A M Sharipov
In spite of considerable progress in development of pediatric science, intensive therapy of kidney diseases remains the pressing issue because of high lethality among patients with renal failure (RF). Cardiovascular diseases, especially malignant hypertension syndrome with development of left ventricular insufficiency, are leading among the causes of late deaths of postdialysis patients. We studied hemodynamics in 18 children with terminal chronic renal failure running with marked arterial hypertension and left ventricular hypertrophy...
May 2002: Urologii︠a︡
A V Zabusov, P S Zhbannikov, I L Denisenko, N I Artamonova
Reaction to infusion of 7.5% sodium chloride solution was studied in 81 patients with endogenous intoxication during development of critical arterial hypotension which could not be prevented or arrested by routine high-dose therapy. The reaction was considered adequate on condition that arterial pressure increased no higher than the safe level, subsequent maintenance of hemodynamics was effective, toxin binding with plasma albumin was increased, diuresis increased, and hypernatriemia was transitory in the presence of general improvement of patient's status...
March 2001: Anesteziologiia i Reanimatologiia
E J Franssen, G G van Essen, A T Portman, J de Jong, G Go, C A Stegeman, D R Uges
The toxicity and pharmacokinetic properties of a drug determine whether hemodialysis and/or hemoperfusion are indicated in acute intoxications. Valproic acid is considered unremovable by hemodialysis because of the high protein binding of 90%-95%. A 27-year-old male with a history of seizures was admitted to the emergency room because of coma, hypernatriemia, and respiratory failure caused by an intoxication with a large dose of valproic acid. At admission, the plasma valproic acid level was 1414 mg/L (9.9 mmol/L) (therapeutic range: 50-100 mg/L (350-700 micromol/ L)...
June 1999: Therapeutic Drug Monitoring
V N Titov
Increased resistance to blood flow in arteries is built up by blockade of transport of saturated fatty acids of triglycerides in VLDL to cell through apoE/B-100 receptor endocytosis (active transport). This way does not affect the structure of cell membrane. Blockade of the active transport stimulates the compensating activation of lipolysis increasing the level of free saturated fatty acids in the blood. These fatty acids are included into the cell membrane via passive transport. In the membrane fatty acids form local domains with unregulated permeability and nonspecific ion transport: Na+ and Ca2+ enter into cell without any control and K+ and Mg2+ leak out...
July 1998: Voprosy Medit︠s︡inskoĭ Khimii
Iu G Monin, O A Goncharevskaia
I. v. administration of 1 M and 2 M NaCl solutions (0.17 ml per 100 g body mass) increased sodium concentration in the blood plasma by 2-5% within 10 min. Hypernatriemia and respective hyperosmia were accompanied by the decrease of the protein level in the blood. The amount of NaCl excretion by kidneys within 1.5 hrs was equal to 18 and 39% of the injected sodium load. Close positive correlation was found between the concentration of osmotically active substances in the blood and reabsorption level of osmotically free water in renal tubules...
January 1983: Fiziologicheskiĭ Zhurnal SSSR Imeni I. M. Sechenova
N Ia Vasin, A A Potapov, O S Iskhakov, Kh M Mukhatzhanov
The effect of osmotic diuretics (mannite and glimarite, 29 studies), colloid-osmotic diuretic (algurin, 22 studies), and saluretic (lasix, 58 studies) on intracranial pressure (ICP) was studied in 30 patients in the acute period of severe craniocerebral injury. It was found that the hypotensive effect of the diuretics depended on the state of the water-electrolyte homeostasis, the time of medication with the agents, the severity of the patient's condition, and the initial ICP. The effect of osmotic diuretics was highest in normoosmia and normonatriemia in ICP of 20-45 mm Hg...
November 1984: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
E S Slavina, L V Kuratev, K N Kazeev, V I Kertsman, V M Iundunov
The results of examination of ECG in 44 patients suffering from Itsenko-Cushing's disease at different stages of surgical treatment are presented. The data obtained were compared with the blood potassium and sodium levels, 17-KS, and 17-OCS levels in the urine, arterial pressure and cholesterol content. Various ECG changes before the operation were revealed in 39 patients. Signs of enlargement of the left ventricle and deformity of the end part of the ventricular complex (negative T wave and or reduction of S-T segment in I, II, avL V5-6 leads) were found in 8 patients, and deformity of the end part of the ventricular complex without any signs of enlargement of the left ventricle--in 18 patients...
July 1977: Problemy E̊ndokrinologii
V M Iundunov, K N Kazeev, V I Kertsman, L V Kuratev
The authors present the results of study of the state of the water-electrolyte metabolism at the early postoperative period in 58 patients suffering from Itsenko-Cushing's disease with consideration of the potassium deficiency correction. Potassium and sodium level was studied in the plasma and the erythrocytes. Besides, in 31 patients potassium and sodium content were examined in the muscular tissue obtained during the operation. Hypoglycemia was revealed in 48.2% of the cases, and hypernatriemia--in 19.0%...
January 1977: Problemy E̊ndokrinologii
I I Vodianova
The author presents the results of parallel studies of potassium, sodium and calcium in the blood plasma and the 24-hour urine of 146 patients suffering from toxic goiter of different severity (mild course in 43 patients, of moderate severity in 59, and severe in 44). Investigations were carried out before and after the treatment with thyrotoxic preparation and in some of the patients (24) after strumectomy. Before the treatment patients with mild and moderately severe forms of the disease showed a tendency to increase of potassium and calcium and a fall of sodium level in the blood...
May 1977: Problemy E̊ndokrinologii
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