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https://www.readbyqxmd.com/read/28043986/a-time-of-change
#1
EDITORIAL
Carl F Nathan, Michel C Nussenzweig, Teodoro Pulvirenti
As Co-Chairs and Executive Editor of The Journal of Experimental Medicine, we write to share some changes that will help us provide JEM authors with the best service we can.
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28040246/risk-of-mortality-in-patients-with-giant-cell-arteritis-a-systematic-review-and-meta-analysis
#2
REVIEW
Catherine L Hill, Rachel J Black, Johannes C Nossent, Carlee Ruediger, Leanne Nguyen, Jem V Ninan, Susan Lester
BACKGROUND: Previous studies of mortality associated with GCA have shown conflicting results. We conducted a systematic review and meta-analysis to determine the mortality risk in GCA patients compared to the general population. METHODS: We searched for published studies indexed in MEDLINE and EMBASE and the Cochrane database from inception to June 18, 2015 using the terms "giant cell arteritis" and "temporal arteritis" combined with the terms for death, mortality, and survival...
August 25, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28003144/self-assembled-supramolecular-polymers-with-tailorable-properties-that-enhance-cell-attachment-and-proliferation
#3
Chih-Chia Cheng, Duu-Jong Lee, Jem-Kun Chen
: Self-assembled supramolecular scaffolds, a combination of noncovalent interactions within a biocompatible polymer substrate, can be used for efficient construction of highly-controlled self-organizing hierarchical structures; these newly-developed biomaterials exhibit excellent mechanical properties, tunable surface hydrophilicity, low cytotoxicity and high biodegradability, making them highly attractive for tissue engineering and regenerative medicine applications. Herein, we demonstrate a novel supramolecular poly(ε-caprolactone) (PCL) containing self-complementary sextuple hydrogen-bonded uracil-diamidopyridine (U-DPy) moieties, which undergoes spontaneous self-assembly to form supramolecular polymer networks...
December 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28000980/qualitative-study-of-peer-workers-within-the-partners-in-recovery-programme-in-regional-australia
#4
John Hurley, Andrew Cashin, Jem Mills, Marie Hutchinson, Desiree Kazlowski, Iain Graham
In Australia and internationally, Peer Workers are increasingly being incorporated into the mental health workforce. Underpinning this trend is the conviction that the inclusion of workers with lived experience in overcoming mental health challenges is central to transforming service delivery. Given there are few identified Australian studies into the experiences of Peer Workers, this paper reports findings from qualitative interviews conducted in a Partners In Recovery programme in one regional area in Australia...
December 21, 2016: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/27973876/narrow-linewidth-excitonic-emission-in-organic-inorganic-lead-iodide-perovskite-single-crystals
#5
Hiba Diab, Gaëlle Trippé-Allard, Ferdinand Lédée, Khaoula Jemli, Christèle Vilar, Guillaume Bouchez, Vincent L R Jacques, Antonio Tejeda, Jacky Even, Jean-Sébastien Lauret, Emmanuelle Deleporte, Damien Garrot
Hybrid perovskite thin films have demonstrated impressive performance for solar energy conversion and optoelectronic applications. However, further progress will benefit from a better knowledge of the intrinsic photophysics of materials. Here, the temperature-dependent emission properties of CH3NH3PbI3 single crystals are investigated and compared to those of thin polycrystalline films by means of steady-state and time-resolved photoluminescence spectroscopy. Single crystals photoluminescence present a sharp excitonic emission at high energy, with full width at half maximum of only 5 meV, assigned to free excitonic recombination...
December 15, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27931811/the-pigret-assay-a-method-for-measuring-pig-a-gene-mutation-in-reticulocytes-is-reliable-as-a-short-term-in-vivo-genotoxicity-test-summary-of-the-mms-jems-collaborative-study-across-16-laboratories-using-24-chemicals
#6
Takafumi Kimoto, Katsuyoshi Horibata, Daishiro Miura, Satsuki Chikura, Yuki Okada, Akiko Ukai, Satoru Itoh, Shiho Nakayama, Hisakazu Sanada, Naomi Koyama, Shigeharu Muto, Yoshifumi Uno, Mika Yamamoto, Yuta Suzuki, Takayuki Fukuda, Ken Goto, Kunio Wada, Takahiro Kyoya, Miyuki Shigano, Hironao Takasawa, Shuichi Hamada, Hideki Adachi, Yasuaki Uematsu, Eri Tsutsumi, Hisako Hori, Ryuta Kikuzuki, Yosuke Ogiwara, Ikuma Yoshida, Akihisa Maeda, Kazunori Narumi, Yohei Fujiishi, Takeshi Morita, Masami Yamada, Masamitsu Honma
The in vivo mutation assay using the X-linked phosphatidylinositol glycan class A gene (Pig-a in rodents, PIG-A in humans) is a promising tool for evaluating the mutagenicity of chemicals. Approaches for measuring Pig-a mutant cells have focused on peripheral red blood cells (RBCs) and reticulocytes (RETs) from rodents. The recently developed PIGRET assay is capable of screening >1×10(6) RETs for Pig-a mutants by concentrating RETs in whole blood prior to flow cytometric analysis. Additionally, due to the characteristics of erythropoiesis, the PIGRET assay can potentially detect increases in Pig-a mutant frequency (MF) sooner after exposure compared with a Pig-a assay targeting total RBCs (RBC Pig-a assay)...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27931809/report-on-the-rat-pig-a-assay-using-an-anti-rat-erythroid-marker-his49-antibody-in-a-single-dose-study-of-1-2-dimethylhydrazine
#7
Satsuki Chikura, Yuki Okada, Takafumi Kimoto, Hideshi Kaneko, Daishiro Miura, Yoshinori Kasahara
As part of a collaborative study in the Mammalian Mutagenicity Study (MMS) Group of the Japanese Environmental Mutagen Society (JEMS), we investigated the in vivo genotoxicity profile of 1,2-dimethylhydrazine (DMH) using a Pig-a assay in total red blood cells (RBC Pig-a assay) or a reticulocyte Pig-a assay (PIGRET assay). We also assessed the genotoxic potential of DMH using both a bone marrow micronucleus test and a liver comet assay as follow-up studies. Single administration of 25, 50, 100mg/kg DMH to male rats did not show time- or dose-related increases in Pig-a mutant frequency (MF) in either the RBC Pig-a or PIGRET assays up to 4 weeks after treatment...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27896686/blastococcus-colisei-sp-nov-isolated-from-an-archaeological-amphitheatre
#8
Karima Hezbri, Imen Nouioui, Manfred Rohde, Peter Schumann, Maher Gtari, Hans-Peter Klenk, Maria Del Carmen Montero-Calasanz, Faten Ghodhbane-Gtari
The taxonomic position of an actinobacterial isolate, designated strain BMG 822(T), isolated from limestone from the Amphitheater of El Jem (Coliseum Thysdrus), Tunisia, was established using a polyphasic approach. Strain BMG 822(T) was found to grow well at 30 °C and pH 6.5-8.0, and to be coral-coloured, Gram-positive, catalase and oxidase negative. Whole cell hydrolysates contained meso-diaminopimelic acid as the diagnostic diamino acid, glucose, galactose and ribose. The phospholipids detected were diphosphatidylglycerol, phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, hydroxy-phosphatidylethanolamine, an unidentified glycophospholipid and six unidentified phospholipids...
November 28, 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27881735/therapy-activated-stromal-cells-can-dictate-tumor-fate
#9
Robert S Kerbel, Yuval Shaked
In this issue of JEM, Chan et al. describe a novel way by which an investigational form of chemotherapy known as low-dose metronomic chemotherapy can inhibit tumor growth, which also has therapeutic implications for targeting tumor-initiating cells (TICs), the tumor stroma, and chemokine receptors, as well as invasion and metastasis.
December 12, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27856424/eradication-of-canine-diffuse-large-b-cell-lymphoma-in-a-murine-xenograft-model-with-cd47-blockade-and-anti-cd20
#10
Kipp Weiskopf, Katie L Anderson, Daisuke Ito, Peter J Schnorr, Hirotaka Tomiyasu, Aaron M Ring, Kristin Bloink, Jem Efe, Sarah Rue, David Lowery, Amira Barkal, Susan Prohaska, Kelly M McKenna, Ingrid Cornax, Timothy D O'Brien, M Gerard O'Sullivan, Irving L Weissman, Jaime F Modiano
Cancer immunotherapies hold much promise, but their potential in veterinary settings has not yet been fully appreciated. Canine lymphomas are among the most common tumors of dogs and bear remarkable similarity to human disease. In this study, we examined the combination of CD47 blockade with anti-CD20 passive immunotherapy for canine lymphoma. The CD47/SIRPα axis is an immune checkpoint that regulates macrophage activation. In humans, CD47 is expressed on cancer cells and enables evasion from phagocytosis...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27842581/impact-of-occupational-exposures-on-exacerbation-of-asthma-a-population-based-asthma-cohort-study
#11
Jeong-Lim Kim, Paul K Henneberger, Susanna Lohman, Anna-Carin Olin, Anna Dahlman-Höglund, Eva Andersson, Kjell Torén, Mathias Holm
BACKGROUND: Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study investigated the association between asthma exacerbations and occupational exposures. METHODS: The study comprised all currently working adults (n = 1356) who reported ever asthma in prior population-based cohorts. All subjects completed a questionnaire about exposures, occupations and exacerbations of asthma...
November 15, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27819519/association-of-the-ifn-%C3%AE-874a-t-genetic-polymorphism-with-paranoid-schizophrenia-in-tunisian-population
#12
Achraf Jemli, Awatef Eshili, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, George Juckel, Besma Bel Hadj Jrad Tensaout
Since growing evidence suggests a significant role of chronic low-grade inflammation in the physiopathology of schizophrenia, we have hypothesized that functional genetic variant of the IFN gamma (IFN-γ; +874A/T; rs2430561) gene may be involved in the predisposition to schizophrenia. This research is based on a case-control study which aims to identify whether polymorphism of the IFN-γ gene is a risk factor for the development of schizophrenia. The RFLP-PCR genotyping of the IFN-γ gene was conducted on a Tunisian population composed of 218 patients and 162 controls...
February 2017: Immunological Investigations
https://www.readbyqxmd.com/read/27777373/occupational-exposures-and-chronic-obstructive-pulmonary-disease-copd-comparison-of-a-copd-specific-job-exposure-matrix-and-expert-evaluated-occupational-exposures
#13
Laura Kurth, Brent Doney, Sheila Weinmann
OBJECTIVES: To compare the occupational exposure levels assigned by our National Institute for Occupational Safety and Health chronic obstructive pulmonary disease-specific job exposure matrix (NIOSH COPD JEM) and by expert evaluation of detailed occupational information for various jobs held by members of an integrated health plan in the Northwest USA. METHODS: We analysed data from a prior study examining COPD and occupational exposures. Jobs were assigned exposure levels using 2 methods: (1) the COPD JEM and (2) expert evaluation...
October 24, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27749985/a-validation-study-associating-glutaminase-promoter-variations-with-hepatic-encephalopathy-in-east-asian-populations
#14
Jem Ma Ahn, Chang Ha Kim, Soon Ho Um, Kyung Mee Kim, Tae Hyung Kim, Sun Young Yim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu
BACKGROUND AND AIM: In a recent study, microsatellite variations (GCA tandem repeats) in the promoter region of the (kidney-type) glutaminase gene were associated with the development of hepatic encephalopathy (HE) in Spanish patients with cirrhosis. The objective of this study was to validate the relation between microsatellite variations in the glutaminase promoter region and the development of overt HE in Korean patients with liver cirrhosis. METHODS: We performed a prospective cohort study of 154 cirrhotic patients who underwent a glutaminase microsatellite study without previous overt HE history at baseline...
October 17, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27722277/multinuclear-nmr-as-a-tool-for-studying-local-order-and-dynamics-in-ch3nh3pbx3-x-cl-br-i-hybrid-perovskites
#15
Claire Roiland, Gaelle Trippé-Allard, Khaoula Jemli, Bruno Alonso, Jean-Claude Ameline, Régis Gautier, Thierry Bataille, Laurent Le Pollès, Emmanuelle Deleporte, Jacky Even, Claudine Katan
We report on (207)Pb, (79)Br, (14)N, (1)H, (13)C and (2)H NMR experiments for studying the local order and dynamics in hybrid perovskite lattices. (207)Pb NMR experiments conducted at room temperature on a series of MAPbX3 compounds (MA = CH3NH3(+); X = Cl, Br and I) showed that the isotropic (207)Pb NMR shift is strongly dependent on the nature of the halogen ions. Therefore (207)Pb NMR appears to be a very promising tool for the characterisation of local order in mixed halogen hybrid perovskites. (207)Pb NMR on MAPbBr2I served as a proof of concept...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27693243/benzyl-isothiocyanate-promotes-apoptosis-of-oral-cancer-cells-via-an-acute-redox-stress-mediated-dna-damage-response
#16
Yao-Tsung Yeh, Yen-Nien Hsu, Sheng-Yun Huang, Jian-Sheng Lin, Zi-Feng Chen, Nan-Haw Chow, Shu-Hui Su, Huey-Wen Shyu, Ching-Chiang Lin, Wu-Tein Huang, Hua Yeh, Yu-Chia Chih, Yu-Hsuan Huang, Shu-Jem Su
Benzyl isothiocyanate (BITC) is a cruciferous vegetable-derived compound with anticancer properties in human cancer cells. However, its anticancer potential and underlying mechanisms remain absent in human oral cancer cells. Results indicate that BITC inhibits growth, promotes G2/M phase arrest and triggers apoptosis of OC2 cells with a minimal toxicity to normal cells. BITC-induced cell death was completely prevented by pretreatment with thiol-containing redox compounds including N-acetyl-l-cysteine (NAC), glutathione (GSH), dithiothreitol, and 2-mercaptoethanol, but not free radical scavengers mito-TEMPO, catalase, apocynin, l-NAME and mannitol...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27687310/vectorized-gene-therapy-of-liver-tumors-proof-of-concept-of-tg4023-mva-fcu1-in-combination-with-flucytosine
#17
F Husseini, J-P Delord, C Fournel-Federico, J Guitton, P Erbs, M Homerin, C Halluard, C Jemming, C Orange, J-M Limacher, J-E Kurtz
BACKGROUND: TG4023 is a modified vaccinia virus Ankara (MVA) containing the yeast-originated transgene FCU1, expressing cytosine deaminase and uracil phosphoribosyltransferase enzymes that transform the prodrug flucytosine (5-FC) into cytotoxic 5-fluorouracil (5-FU) and 5-fluorouridine-5'-monophosphate (5-FUMP), respectively. This first-in-human study aimed to assess the maximum tolerated dose (MTD) of intra-tumoral (IT) TG4023 and the safety, feasibility, and proof-of-concept (PoC) of TG4023/5-FC combination to deliver high 5-FU concentrations in tumors...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27662808/rapid-fabrication-of-carbon-quantum-dots-as-multifunctional-nanovehicles-for-dual-modal-targeted-imaging-and-chemotherapy
#18
Sheng-Hui Chiu, Gangaraju Gedda, Wubshet Mekonnen Girma, Jem-Kun Chen, Yong-Chien Ling, Anil V Ghule, Keng-Liang Ou, Jia-Yaw Chang
: Herein, we synthesized an S, N, and Gd tri-element doped magnetofluorescent carbon quantum dots (GdNS@CQDs) within 10min by using a one-pot microwave method. Our results showed that these magnetofluorescent GdNS@CQDs have excellent fluorescent and magnetic properties. Moreover, GdNS@CQDs exhibited high stability at physiological conditions and ionic strength. These magnetofluorescent GdNS@CQDs were conjugated with a folic acid, denoted as FA-GdNS@CQDs, for targeting dual modal fluorescence/magnetic resonance (MR) imaging...
September 20, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27651695/oncological-safety-of-breast-conservation-surgery-in-young-females
#19
Madhu Muralee, Arun Peter Mathew, Kurian Cherian, K Chandramohan, Paul Augustine, Jem Prabhakar, Iqbal Ahamed
Breast conservation surgery (BCS) is the standard of care in early breast cancer. The oncological safety of this procedure has been proven beyond doubt in several randomised control trials. But there are concerns regarding the safety of this procedure in young females. The concern is regarding increased risk of local recurrence. This issue has not been addressed in any major trial. In this prospective study we intend to look into the oncological safety of BCS in young patients who are less than forty years of age...
September 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27639492/supermolecules-of-poly-n-isopropylacrylamide-complexating-herring-sperm-dna-with-bio-multiple-hydrogen-bonding
#20
Ai-Wei Lee, Cheng-Chen Hsu, Yi-Zu Liu, Po-Li Wei, Jem-Kun Chen
In this study we used the poly(N-isopropylacrylamide) (PNIPAAm) as a medium to blend with an organic DNA, herring sperm DNA (HSD), to generate PNIPAAm-HSD supramolecular complexes. Bio-multiple hydrogen bonding (BMHB) between PNIPAAm and HSD was investigated that changed the temperature responsiveness of PNIPAAm relatively to the HSD concentrations. With blending the HSD into PNIPAAm matrix, the phase separation in solution is completely opposite from that of neat PNIPAAm. Surface property in static water contact angle (SWCA) is also opposite from that of pure PNIPAAm upon increasing HSD content over 60%...
December 1, 2016: Colloids and Surfaces. B, Biointerfaces
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