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https://www.readbyqxmd.com/read/28424247/location-in-the-spleen-dictates-the-function-of-murine-neutrophils
#1
Patrizia Scapini, Marco A Cassatella
In this issue of JEM, Deniset et al. (https://doi.org/10.1084/jem.20161621) provide new data that extend our knowledge on the mechanisms whereby Streptococcus pneumoniae is cleared by the spleen. The authors identify novel populations of murine splenic neutrophils that localize in the red pulp and the marginal zone. During the acute phases of S. pneumoniae infection, these populations of splenic neutrophils act in concert with specialized macrophage and B cell populations to provide very rapid innate immune protection...
April 19, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28420734/mink1-the-missing-link-between-ros-and-its-inhibition-of-th17-cells
#2
Gustavo J Martinez
In this issue of JEM, Fu et al. (https://doi.org/10.1084/jem.20161120) identified the kinase Mink1 as a novel negative regulator of Th17 cell generation. Mink1, activated by reactive oxygen species (ROS), prevents TGF-β activation of Smad2, therefore limiting Th17 cell differentiation.
April 18, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28395314/evaluating-exposure-response-associations-for-non-hodgkin-lymphoma-with-varying-methods-of-assigning-cumulative-benzene-exposure-in-the-shanghai-women-s-health-study
#3
Melissa C Friesen, Bryan A Bassig, Roel Vermeulen, Xiao-Ou Shu, Mark P Purdue, Patricia A Stewart, Yong-Bing Xiang, Wong-Ho Chow, Bu-Tian Ji, Gong Yang, Martha S Linet, Wei Hu, Yu-Tang Gao, Wei Zheng, Nathaniel Rothman, Qing Lan
Objectives: To provide insight into the contributions of exposure measurements to job exposure matrices (JEMs), we examined the robustness of an association between occupational benzene exposure and non-Hodgkin lymphoma (NHL) to varying exposure assessment methods. Methods: NHL risk was examined in a prospective population-based cohort of 73087 women in Shanghai. A mixed-effects model that combined a benzene JEM with >60000 short-term, area benzene inspection measurements was used to derive two sets of measurement-based benzene estimates: 'job/industry-specific' estimates (our presumed best approach) were derived from the model's fixed effects (year, JEM intensity rating) and random effects (occupation, industry); 'calibrated JEM' estimates were derived using only the fixed effects...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28356332/occupational-exposure-and-amyotrophic-lateral-sclerosis-in-a-prospective-cohort
#4
Tom Koeman, Pauline Slottje, Leo J Schouten, Susan Peters, Anke Huss, Jan H Veldink, Hans Kromhout, Piet A van den Brandt, Roel Vermeulen
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69 years at enrolment in 1986 were followed up for 17.3 years on ALS mortality. Information on occupational history and potential confounders were collected at baseline through a self-administered questionnaire and entered for a random subcohort (2092 men and 2074 women) and ALS deaths (76 men and 60 women)...
March 29, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28352117/berkson-error-adjustment-and-other-exposure-surrogates-in-occupational-case-control-studies-with-application-to-the-canadian-interocc-study
#5
Tamer Oraby, Siva Sivaganesan, Joseph D Bowman, Laurel Kincl, Lesley Richardson, Mary McBride, Jack Siemiatycki, Elisabeth Cardis, Daniel Krewski
Many epidemiological studies assessing the relationship between exposure and disease are carried out without data on individual exposures. When this barrier is encountered in occupational studies, the subject exposures are often evaluated with a job-exposure matrix (JEM), which consists of mean exposure for occupational categories measured on a comparable group of workers. One of the objectives of the seven-country case-control study of occupational exposure and brain cancer risk, INTEROCC, was to investigate the relationship of occupational exposure to electromagnetic fields (EMF) in different frequency ranges and brain cancer risk...
March 29, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28348204/hiv-persistence-through-division
#6
Lillian B Cohn, Michel C Nussenzweig
A long-lived latent reservoir for HIV-1 persists in CD4(+) T cells despite antiretroviral therapy and is the major barrier to cure. In this issue of JEM, Hosmane et al. show that T cell proliferation could explain the long-term persistence of this reservoir.
April 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28336744/association-of-respiratory-symptoms-and-asthma-with-occupational-exposures-findings-from-a-population-based-cross-sectional-survey-in-telemark-norway
#7
R Abrahamsen, A K M Fell, M V Svendsen, E Andersson, K Torén, P K Henneberger, J Kongerud
OBJECTIVES: The aim of this study was to estimate the prevalence of respiratory symptoms and physician-diagnosed asthma and assess the impact of current occupational exposure. DESIGN: Cross-sectional analyses of the prevalence of self-reported respiratory health and association with current occupational exposure in a random sample of the general population in Telemark County, Norway. SETTINGS: In 2013, a self-administered questionnaire was mailed to a random sample of the general population, aged 16-50, in Telemark, Norway...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28319818/a-task-based-assessment-of-parental-occupational-exposure-to-pesticides-and-childhood-acute-lymphoblastic-leukemia
#8
Robert B Gunier, Alice Kang, S Katharine Hammond, Kyndaron Reinier, C Suzanne Lea, Jeffrey S Chang, Monique Does, Ghislaine Scelo, Janice Kirsch, Vonda Crouse, Robert Cooper, Patricia Quinlan, Catherine Metayer
OBJECTIVES: Associations between parental occupational pesticide exposure and childhood acute lymphoblastic leukemia (ALL) vary across studies, likely due to different exposure assessment methodologies. METHODS: We assessed parental occupational pesticide exposure from the year before pregnancy to the child's third year of life for 669 children diagnosed with ALL and 1021 controls. We conducted expert rating using task-based job modules (JM) to estimate exposure to pesticides among farmer workers, gardeners, agricultural packers, and pesticide applicators...
March 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28299449/contribution-of-job-exposure-matrices-for-exposure-assessment-in-occupational-safety-and-health-monitoring-systems-application-from-the-french-national-occupational-disease-surveillance-and-prevention-network
#9
Arnaud Florentin, Denis Zmirou-Navier, Christophe Paris
OBJECTIVES: To detect new hazards ("signals"), occupational health monitoring systems mostly rest on the description of exposures in the jobs held and on reports by medical doctors; these are subject to declarative bias. Our study aims to assess whether job-exposure matrices (JEMs) could be useful tools for signal detection by improving exposure reporting. METHODS: Using the French national occupational disease surveillance and prevention network (RNV3P) data from 2001 to 2011, we explored the associations between disease and exposure prevalence for 3 well-known pathology/exposure couples and for one debatable couple...
March 16, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28295002/-ultrastructural-characteristics-of-gap-junctions-in-human-glial-brain-tumors
#10
E Yu Kirichenko, A F Savchenko, D V Kozachenko, A E Matsionis, A K Logvinov
AIM: to conduct an electron microscopic study of intercellular communication in the samples of gemistocytic astrocytoma, oligodendroglioma, and glioblastoma. MATERIAL AND METHODS: Surgically resected tumor tissue fragments were fixed in 2.5% glutaraldehyde solution, afterfixed in 1% OsO4 solution, dehydrated, and embedded in epoxy resin. Ultrathin sections were examined using a Jem 1011 electron microscope (Jeol, Japan). RESULTS: Solitary and closely spaced gap junctions (GJs) formed by the thin processes that have the ultrastructure of an astroglial processes were identified in the astrocytoma samples...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28265305/the-10th-anniversary-of-the-publication-of-genes-and-environment-memoir-of-establishing-the-japanese-environmental-mutagen-society-and-a-proposal-for-a-new-collaborative-study-on-mutagenic-hormesis
#11
Shizuyo Sutou
The Japanese Environmental Mutagen Society (JEMS) was established in 1972 by 147 members, 11 of whom are still on the active list as of May 1, 2016. As one of them, I introduce some historic topics here. These include 1) establishment of JEMS, 2) the issue of 2-(2-furyl)-3-(3-nitro-2-furyl)acrylamide (AF-2), 3) the Mammalian Mutagenicity Study Group (MMS) and its achievements, and 4) the Collaborative Study Group of the Micronucleus Test (CSGMT) and its achievements. In addition to these historic matters, some of which are still ongoing, a new collaborative study is proposed on adaptive response or hormesis by mutagens...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28262960/estimation-of-occupational-cosmic-radiation-exposure-among-airline-personnel-agreement-between-a-job-exposure-matrix-aggregate-and-individual-dose-estimates
#12
Madar Talibov, Raili Salmelin, Susanna Lehtinen-Jacks, Anssi Auvinen
BACKGROUND: Job-exposure matrices (JEM) are used for exposure assessment in occupational studies, but they can involve errors. We assessed agreement between the Nordic Occupational Cancer Studies JEM (NOCCA-JEM) and aggregate and individual dose estimates for cosmic radiation exposure among Finnish airline personnel. METHODS: Cumulative cosmic radiation exposure for 5,022 airline crew members was compared between a JEM and aggregate and individual dose estimates...
March 6, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28260879/occupational-copd-and-job-exposure-matrices-a-systematic-review-and-meta-analysis
#13
REVIEW
Steven Sadhra, Om P Kurmi, Sandeep S Sadhra, Kin Bong Hubert Lam, Jon G Ayres
BACKGROUND: The association between occupational exposure and COPD reported previously has mostly been derived from studies relying on self-reported exposure to vapors, gases, dust, or fumes (VGDF), which could be subjective and prone to biases. The aim of this study was to assess the strength of association between exposure and COPD from studies that derived exposure by job exposure matrices (JEMs). METHODS: A systematic search of JEM-based occupational COPD studies published between 1980 and 2015 was conducted in PubMed and EMBASE, followed by meta-analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28251957/-contamination-of-exosome-preparations-isolated-from-biological-fluids
#14
A E Grigor'eva, N S Dyrkheeva, O E Bryzgunova, S N Tamkovich, B P Chelobanov, E I Ryabchikova
The aim of our study was to attract the attention of researchers at the problem of contamination of exosome preparations. Using a transmission electron microscope JEM-1400 ("JEOL", Japan) we have examined exosome preparations, isolated according to the conventional scheme of sequential centrifugation from different biological fluids: plasma and urine of healthy persons and patients with oncologic diseases, bovine serum, and culture fluid (MDCK, MDA-MB и MCF-7 cells). All exosome preparations (over 200) contained exosomes, which were identified by immuno-electron microscopy using antibodies to tetraspanins CD63 or CD9...
January 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28250868/evolution-of-genotoxicity-test-methods-in-japan
#15
Toshio Sofuni
The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of Japan (at that time) organized a research group (Organizer: Y. Tazima, National Institute of Genetics), and started a systematic research on the genotoxic effects induced by chemical substances. Considering the importance of this issue through the outcomes of the research group, JEMS was established in 1972, and President Tazima organized the 1st annual meeting in the August in Tokyo with the participation of experts in this field working in national institutes, universities and others in Japan...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28177438/vectorized-gene-therapy-of-liver-tumors-proof-of-concept-of-tg4023-mva-fcu1-in-combination-with-flucytosine
#16
F Husseini, J-P Delord, C Fournel-Federico, J Guitton, P Erbs, M Homerin, C Halluard, C Jemming, C Orange, J-M Limacher, J-E Kurtz
No abstract text is available yet for this article.
January 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28152614/phytochemical-and-pharmacological-variability-in-golden-thistle-functional-parts-comparative-study-of-roots-stems-leaves-and-flowers
#17
Ilias Marmouzi, Miloud El Karbane, Maha El Hamdani, Mourad Kharbach, Hanae Naceiri Mrabti, Rachid Alami, Souhail Dahraoui, Meryem El Jemli, Zhor Ouzzif, Yahia Cherrah, Soufiane Derraji, My El Abbes Faouzi
Scolymus hispanicus or the Golden Thistle, locally known as 'Guernina' or 'Taghediwt', is one of the most appreciated wild vegetables in Morocco. This study aims to characterise the functional chemical and pharmacological variability of Scolymus hispanicus parts (roots, stems, leaves and flowers). The chemical analysis revealed higher content of α-tocopherol in the flowers (2.79 ± 0.07 mg/100 g) and lead to the identification of 3 flavonoids and 13 phenolic acids, with high content of gallic acid in leaves (187...
February 2, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28043986/a-time-of-change
#18
EDITORIAL
Carl F Nathan, Michel C Nussenzweig, Teodoro Pulvirenti
As Co-Chairs and Executive Editor of The Journal of Experimental Medicine, we write to share some changes that will help us provide JEM authors with the best service we can.
January 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28040246/risk-of-mortality-in-patients-with-giant-cell-arteritis-a-systematic-review-and-meta-analysis
#19
REVIEW
Catherine L Hill, Rachel J Black, Johannes C Nossent, Carlee Ruediger, Leanne Nguyen, Jem V Ninan, Susan Lester
BACKGROUND: Previous studies of mortality associated with GCA have shown conflicting results. We conducted a systematic review and meta-analysis to determine the mortality risk in GCA patients compared to the general population. METHODS: We searched for published studies indexed in MEDLINE and EMBASE and the Cochrane database from inception to June 18, 2015 using the terms "giant cell arteritis" and "temporal arteritis" combined with the terms for death, mortality, and survival...
August 25, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28003144/self-assembled-supramolecular-polymers-with-tailorable-properties-that-enhance-cell-attachment-and-proliferation
#20
Chih-Chia Cheng, Duu-Jong Lee, Jem-Kun Chen
Self-assembled supramolecular scaffolds, a combination of noncovalent interactions within a biocompatible polymer substrate, can be used for efficient construction of highly-controlled self-organizing hierarchical structures; these newly-developed biomaterials exhibit excellent mechanical properties, tunable surface hydrophilicity, low cytotoxicity and high biodegradability, making them highly attractive for tissue engineering and regenerative medicine applications. Herein, we demonstrate a novel supramolecular poly(ε-caprolactone) (PCL) containing self-complementary sextuple hydrogen-bonded uracil-diamidopyridine (U-DPy) moieties, which undergoes spontaneous self-assembly to form supramolecular polymer networks...
December 18, 2016: Acta Biomaterialia
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