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JEMS

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https://www.readbyqxmd.com/read/29342223/development-of-a-job-exposure-matrix-for-noise-in-the-swedish-soft-tissue-paper-industry
#1
Richard Lee Neitzel, Marianne Andersson, Helena Eriksson, Kjell Torén, Eva Andersson
Objectives: Noise exposure is a common occupational hazard, but has not been sufficiently characterized in paper mills. We developed a job-exposure matrix (JEM) for noise exposure for use in estimating exposures among Swedish soft tissue paper mill workers. Methods: We used a combination of area and personal dosimetry noise exposure measurements made at four soft tissue paper mills by industry and research staff between 1977 and 2013 to estimate noise exposures by department, location, and job title...
December 16, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29338768/binary-blend-fibber-based-capture-assay-of-circulating-tumor-cells-for-clinical-diagnosis-of-colorectal-cancer
#2
Ai-Wei Lee, Fu-Xiang Lin, Po-Li Wei, Guo Jian-Wei, Jem-Kun Chen
BACKGROUND: In addition to conventional approaches, detecting and characterizing CTCs in patient blood allows for early diagnosis of cancer metastasis. METHODS: We blended poly(ethylene oxide) (PEO) into nylon-6 through electrospinning to generate a fibrous matbased circulating tumour cells (CTCs) assay. The contents of nylon-6 and PEO in the electrospun blend fibrous mats (EBFMs) were optimized to facilitate high cell-substrate affinity and low leukocyte adsorption...
January 16, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29323398/night-shift-work-and-hematological-cancers-a-population-based-case-control-study-in-three-nordic-countries
#3
Madar Talibov, Eero Pukkala, Jan Ivar Martinsen, Laufey Tryggvadottir, Elisabete Weiderpass, Johnni Hansen
Objective The aim of this case-control study was to assess the effect of night-shift work on the risk of hematological cancers. Methods The study included 39 371 leukemia, 56 713 non-Hodgkin lymphoma, 9322 Hodgkin lymphoma, and 26 188 multiple myeloma cases diagnosed between 1961 and 2005 in Finland, Sweden, and Iceland. Five controls for each case were selected from the Nordic Occupational Cancer Study (NOCCA) cohort, matched by year of birth, sex and country. Night-shift exposure was assessed by using the NOCCA job-exposure matrix (JEM)...
January 11, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29305928/anti-proliferative-activity-of-biochanin-a-in-human-osteosarcoma-cells-via-mitochondrial-involved-apoptosis
#4
Yen-Nien Hsu, Huey-Wen Shyu, Tsui-Wen Hu, Jou-Pei Yeh, Ya-Wen Lin, Ling-Yi Lee, Yao-Tsung Yeh, Hong-Ying Dai, Daw-Shyong Perng, Shu-Hui Su, Yu-Hsuan Huang, Shu-Jem Su
Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. The results indicate that biochanin A inhibited cell growth and colony formation in a dose-dependent manner with a minimal toxicity to normal cells. The combination of doxorubicin and biochanin A could synergistically inhibit osteosarcoma cell growth...
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29300061/fabrication-of-an-artificial-nanosucker-device-with-a-large-area-nanotube-array-of-metallic-glass
#5
Wei-Ting Chen, Karthikeyan Manivannan, Chia-Chi Yu, Jinn P Chu, Jem-Kun Chen
The concurrent attachment and detachment movements of geckos on virtually any type of surface via their foot pads have inspired us to develop a thermal device with numerous arrangements of a multi-layer thin film together with electrodes that can help modify the temperature of the surface via application of a voltage. A sequential fabrication process was employed on a large-scale integration to generate well-defined contact hole arrays of photoresist for use as templates on the electrode-based device. The photoresist templates were then subjected to sputter deposition of the metallic glass Zr55Cu30Al10Ni5...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29275242/maternal-cumulative-exposure-to-extremely-low-frequency-electromagnetic-fields-and-pregnancy-outcomes-in-the-elfe-cohort
#6
L Migault, C Piel, C Carles, F Delva, A Lacourt, E Cardis, C Zaros, R de Seze, I Baldi, G Bouvier
OBJECTIVES: To study the relations between maternal cumulative exposure to extremely low frequency electromagnetic fields (ELF EMF) and the risk of moderate prematurity and small for gestational age within the Elfe cohort. METHODS: The Elfe study included 18,329 infants born at 33weeks of gestation or more in France in 2011 and was designed to follow the children until 20years of age. Gestational age and anthropometric data at birth were collected in medical records and small for gestational age was defined according to a French customized growth standard...
December 20, 2017: Environment International
https://www.readbyqxmd.com/read/29222106/psma-brings-new-flavors-to-pi3k-signaling-a-role-for-glutamate-in-prostate-cancer
#7
Lavinia Palamiuc, Brooke M Emerling
In this issue of JEM, Kaittanis et al. (https://doi.org/10.1084/jem.20171052) report a new signaling role for prostate-specific membrane antigen (PSMA), providing a mechanistic link between two major oncogenic pathways, as well as promising therapeutic implications for the diagnosis and treatment of prostate cancer.
December 8, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29220131/jems-selects-top-10-innovators-of-2016
#8
Elisse Miller
No abstract text is available yet for this article.
April 2017: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/29207134/novel-herbal-medicine-la16001-ameliorates-cisplatin-induced-anorexia
#9
Sang-Mi Woo, Kang Min Lee, Gyu Ri Lee, Ji Youn Park, Hee Jae Lee, Hyo-Jung Bahn, Hyun Seok Yoon, Jem Yung Kim, Young Cheol Shin, Sung-Gook Cho, Seong-Gyu Ko
Chemotherapy frequently causes anorexia in cancer patients, which has been associated with poor disease prognosis. Several therapeutic strategies for the treatment of chemotherapy‑induced anorexia are available; however, their adverse effects limit their clinical use. Herbal medicines have a long history of use for the treatment of various diseases, including cancer, and recent research has demonstrated their safety and efficacy. In the present study, combinations of herbal medicines were designed based on traditional Korean medicine, and their effects were investigated on chemotherapy‑induced anorexia...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29196507/fcrn-is-mother-s-milk-to-allergen-tolerance
#10
Bart N Lambrecht
In this issue Ohsaki et al. (https://doi.org/10.1084/jem.20171163) explain how breastfeeding can prevent the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic cells (DCs).
December 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29191587/phenotypes-of-lung-cancer-and-statistical-interactions-between-tobacco-smoking-and-occupational-exposure-to-asbestos-and-crystalline-silica-from-a-large-case-only-study-the-capromat-study
#11
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Christophe Paris, Jean Claude Pairon, Antoine Gislard, Jack Siemiatycki, Vincent Bonneterre, Bénédicte Clin, Patrick Brochard, Fleur Delva, Aude Lacourt
OBJECTIVES: The aim of this study was to assess the effect modification of the association between tobacco smoking and phenotypes of lung cancer (histological type, tumor location, and age at diagnosis) by occupational exposure to asbestos or to crystalline silica. MATERIALS AND METHODS: The CaProMat study is a pooled case-only study including 7256 male lung cancer cases recruited between 1996 and 2011 in France and Canada. Two job-exposure matrices (JEMs) were used to assess occupational exposure to asbestos and crystalline silica...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29187610/the-new-face-of-jem
#12
Carl Nathan, Michel Nussenzweig, Teodoro Pulvirenti
We are excited to introduce a new design for JEM.
December 4, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29183989/left-or-right-directions-to-stem-cell-engraftment
#13
Mirjam E Belderbos, Leonid Bystrykh, Gerald de Haan
In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20171341) use genetic barcoding of macaque hematopoietic stem cells to demonstrate that, after transplantation, HSCs are very asymmetrically distributed and uncover a thymus-independent pathway for mature T cell production in the bone marrow.
November 28, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29163223/have-the-findings-from-clinical-risk-prediction-and-trials-any-key-messages-for-safety-pharmacology
#14
REVIEW
Jem D Lane, Andrew Tinker
Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias. However, they also have the potential for pro-arrhythmia and thus the prediction of arrhythmia predisposition and drug response are critical issues. Clinical trials are the latter stages in the safety testing and efficacy process prior to market release, and as such serve as a critical safeguard. In this review, we look at some of the lessons to be learned from approaches to arrhythmia prediction in patients, clinical trials of drugs used in the treatment of arrhythmias, and the implications for the design of pre-clinical safety pharmacology testing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162645/the-amazing-brain-drain
#15
Marie Blanchette, Richard Daneman
In this issue of JEM, Antila et al. (https://doi.org/10.1084/jem.20170391) demonstrate that central nervous system lymphatics develop in the mouse meninges during early postnatal periods and display remarkable plasticity in adult periods through manipulation of VEGF-C-VEGFR3 signaling.
November 21, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29162644/a-role-for-astroglia-in-prion-diseases
#16
Adriano Aguzzi, Yingjun Liu
In this issue of JEM, Krejciova et al. (https://doi.org/10.1084/jem.20161547) report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds that might serve as clinical candidates. Furthermore, they add to the evidence that astrocytes may not be just innocent bystanders in prion diseases.
December 4, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29158375/nsd3-keeps-irf3-active
#17
Takashi Mino, Osamu Takeuchi
In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.
November 20, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29150429/cgamp-a-tale-of-two-signals
#18
Teneema Kuriakose, Thirumala-Devi Kanneganti
In this issue of JEM, Swanson et al. (https://doi.org/10.1084/jem.20171749) report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-sensing pathway.
November 17, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29132097/the-development-of-a-new-artificial-model-of-a-finger-for-assessing-transmitted-vibrations
#19
Almaky Almagirby, Jem A Rongong, Matt J Carré
Prolonged exposure of the hand to tool-induced vibrations is associated with the occurrence of conditions such as vibration white finger. This study involves the development of a new artificial model that approximates both loading and vibration behaviour of the human finger. The layered system uses polypropylene "bones", encased in a cylinder of low modulus, room-temperature curing silicone gel (to replicate subcutaneous tissues), with an outer layer of latex (to replicate the dermis and epidermis). A protocol for manufacture was developed and dynamic mechanical analysis was carried out on a range of gels in order to choose a range close to the mechanical properties of the human finger...
November 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29128715/fabrication-of-ordered-metallic-glass-nanotube-arrays-for-label-free-biosensing-with-diffractive-reflectance
#20
Wei-Ting Chen, Shao-Sian Li, Jinn P Chu, Kuei Chih Feng, Jem-Kun Chen
In this study, a photoresist template with well-defined contact hole array was fabricated, to which radio frequency magnetron sputtering process was then applied to deposit an alloyed Zr55Cu30Al10Ni5 target, and finally resulted in ordered metallic glass nanotube (MGNT) arrays after removal of the photoresist template. The thickness of the MGNT walls increased from 98 to 126nm upon increasing the deposition time from 225 to 675s. The wall thickness of the MGNT arrays also increased while the dimensions of MGNT reduced under the same deposition condition...
October 18, 2017: Biosensors & Bioelectronics
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