keyword
MENU ▼
Read by QxMD icon Read
search

JEMS

keyword
https://www.readbyqxmd.com/read/28600993/robust-sensitive-and-facile-method-for-detection-of-f-cn-and-ac-anions
#1
P Madhusudhana Reddy, Shih-Rong Hsieh, Jem-Kun Chen, Chi-Jung Chang, Jing-Yuan Kang, Chih-Hsien Chen
Sensing of F(-), CN(-) and Ac(-) is important from the viewpoint of both medically and environmentally. Particularly, sensing of the anions in 100% water by a colorimetric chemical sensor is a highly difficult task as water molecules interfere the sensing mechanism. In this regard, sensor R1, having azo and nitrophenyl groups as signaling units and thiourea as a binding site was prepared. This sensor exclusively detected CN(-) ion over other testing anions in 30% aq. DMSO solution by exhibiting distinct spectral and visual color changes...
June 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28571111/occupational-solvent-exposure-and-adult-chronic-lymphocytic-leukemia-no-risk-in-a-population-based-case-control-study-in-four-nordic-countries
#2
Madar Talibov, Anssi Auvinen, Elisabete Weiderpass, Johnni Hansen, Jan-Ivar Martinsen, Kristina Kjaerheim, Laufey Tryggvadottir, Eero Pukkala
The aim of this study was to assess the effect of occupational solvent exposure on the risk of adult chronic lymphocytic leukemia (CLL). The current case-control study was nested in the Nordic Occupational Cancer Study (NOCCA) cohort. 20,615 CLL cases diagnosed in 1961-2005 in Finland, Iceland, Norway, and Sweden, and 103,075 population-based controls matched by year of birth, sex, and country were included. Occupational histories for cases and controls were obtained from census records in 1960, 1970, 1980/1981, and 1990...
June 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28536240/reply-to-tolerogenic-insulin-peptide-therapy-precipitates-type-1-diabetes
#3
Carolin Daniel, Benno Weigmann, Harald von Boehmer
In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3(+) regulatory T cell conversion.
May 23, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28532503/an-updated-predict-breast-cancer-prognostication-and-treatment-benefit-prediction-model-with-independent-validation
#4
Francisco J Candido Dos Reis, Gordon C Wishart, Ed M Dicks, David Greenberg, Jem Rashbass, Marjanka K Schmidt, Alexandra J van den Broek, Ian O Ellis, Andrew Green, Emad Rakha, Tom Maishman, Diana M Eccles, Paul D P Pharoah
BACKGROUND: PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case series, but PREDICT has been shown to underestimate breast cancer specific mortality in women diagnosed under the age of 40. Another limitation is the use of discrete categories for tumour size and node status resulting in 'step' changes in risk estimates on moving between categories. We have refitted the PREDICT prognostic model using the original cohort of cases from East Anglia with updated survival time in order to take into account age at diagnosis and to smooth out the survival function for tumour size and node status...
May 22, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28526760/tissue-resident-t-cells-in-hepatitis-b-a-new-target-for-cure
#5
Fabian J Bolte, Barbara Rehermann
A hallmark of chronic hepatitis B virus (HBV) infection is the functional impairment and depletion of antiviral T cells. In this issue of JEM, Pallett et al. (https://doi.org/10.1084/jem.20162115) identify a reservoir of functional HBV-specific T cells among liver-resident T cells.
June 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28515074/immune-checkpoints-on-innate-lymphoid-cells
#6
Laura Chiossone, Eric Vivier
In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti-PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice.
June 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28490661/surgery-for-subacromial-impingement-syndrome-in-relation-to-occupational-exposures-lifestyle-factors-and-diabetes-mellitus-a-nationwide-nested-case-control-study
#7
Annett Dalbøge, Poul Frost, Johan Hviid Andersen, Susanne Wulff Svendsen
OBJECTIVES: To estimate the risk of surgery for subacromial impingement syndrome (SIS) in relation to occupational exposures, lifestyle factors and diabetes mellitus. METHODS: We conducted a case-control study nested in a register-based cohort study of the Danish working population. For each of 3000 first-time cases of surgery for SIS, two age-matched and sex-matched controls were drawn. Cases and controls received a questionnaire on job history and other factors...
May 10, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28485026/giant-cell-arteritis-beyond-temporal-artery-biopsy-and-steroids
#8
REVIEW
Jem V Ninan, Susan Lester, Catherine L Hill
Giant cell arteritis is the commonest primary vasculitis of the elderly. The acute complications of untreated Giant cell arteritis such as vision loss or occasionally stroke can be devastating. The diagnosis is however not altogether straightforward due to variable sensitivities of the temporal artery biopsy as a reference diagnostic test. In this review, we discuss the increasing role of imaging in the diagnosis of Giant cell arteritis. Glucocorticoid treatment is the backbone of therapy but it is associated with significant adverse effects...
May 9, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28482615/design-of-poly-mpegma-co-maa-hydrogel-based-mpeg-b-pcl-nanoparticles-for-oral-meloxicam-delivery
#9
Yongli Shi, Zhaomin Liu, Yaxing Yang, Xiaojie Xu, Yan Li, Tong Li
To enhance the therapeutic effects of meloxicam (MLX), we developed an oral MLX-loaded poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles@hydrogel (MLX-NPs@hydrogel) preparation. The MLX-NPs were fabricated via a solvent evaporation method, and their morphologies were observed by a JEM-1011 transmission electron microscope (TEM). The poly(mPEGMA-co-MAA) hydrogels were synthesized, and studies on their pH sensibilities were carried out in pH1.2, 6.8, and 7.4 buffers. The final MLX-NPs@hydrogel preparation was obtained by immersing the hydrogels in the MLX-NPs suspensions (pH7...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28424247/location-in-the-spleen-dictates-the-function-of-murine-neutrophils
#10
Patrizia Scapini, Marco A Cassatella
In this issue of JEM, Deniset et al. (https://doi.org/10.1084/jem.20161621) provide new data that extend our knowledge on the mechanisms whereby Streptococcus pneumoniae is cleared by the spleen. The authors identify novel populations of murine splenic neutrophils that localize in the red pulp and the marginal zone. During the acute phases of S. pneumoniae infection, these populations of splenic neutrophils act in concert with specialized macrophage and B cell populations to provide very rapid innate immune protection...
May 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28420734/mink1-the-missing-link-between-ros-and-its-inhibition-of-th17-cells
#11
Gustavo J Martinez
In this issue of JEM, Fu et al. (https://doi.org/10.1084/jem.20161120) identified the kinase Mink1 as a novel negative regulator of Th17 cell generation. Mink1, activated by reactive oxygen species (ROS), prevents TGF-β activation of Smad2, therefore limiting Th17 cell differentiation.
May 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28395314/evaluating-exposure-response-associations-for-non-hodgkin-lymphoma-with-varying-methods-of-assigning-cumulative-benzene-exposure-in-the-shanghai-women-s-health-study
#12
Melissa C Friesen, Bryan A Bassig, Roel Vermeulen, Xiao-Ou Shu, Mark P Purdue, Patricia A Stewart, Yong-Bing Xiang, Wong-Ho Chow, Bu-Tian Ji, Gong Yang, Martha S Linet, Wei Hu, Yu-Tang Gao, Wei Zheng, Nathaniel Rothman, Qing Lan
Objectives: To provide insight into the contributions of exposure measurements to job exposure matrices (JEMs), we examined the robustness of an association between occupational benzene exposure and non-Hodgkin lymphoma (NHL) to varying exposure assessment methods. Methods: NHL risk was examined in a prospective population-based cohort of 73087 women in Shanghai. A mixed-effects model that combined a benzene JEM with >60000 short-term, area benzene inspection measurements was used to derive two sets of measurement-based benzene estimates: 'job/industry-specific' estimates (our presumed best approach) were derived from the model's fixed effects (year, JEM intensity rating) and random effects (occupation, industry); 'calibrated JEM' estimates were derived using only the fixed effects...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28356332/occupational-exposure-and-amyotrophic-lateral-sclerosis-in-a-prospective-cohort
#13
Tom Koeman, Pauline Slottje, Leo J Schouten, Susan Peters, Anke Huss, Jan H Veldink, Hans Kromhout, Piet A van den Brandt, Roel Vermeulen
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69 years at enrolment in 1986 were followed up for 17.3 years on ALS mortality. Information on occupational history and potential confounders were collected at baseline through a self-administered questionnaire and entered for a random subcohort (2092 men and 2074 women) and ALS deaths (76 men and 60 women)...
March 29, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28352117/berkson-error-adjustment-and-other-exposure-surrogates-in-occupational-case-control-studies-with-application-to-the-canadian-interocc-study
#14
Tamer Oraby, Siva Sivaganesan, Joseph D Bowman, Laurel Kincl, Lesley Richardson, Mary McBride, Jack Siemiatycki, Elisabeth Cardis, Daniel Krewski
Many epidemiological studies assessing the relationship between exposure and disease are carried out without data on individual exposures. When this barrier is encountered in occupational studies, the subject exposures are often evaluated with a job-exposure matrix (JEM), which consists of mean exposure for occupational categories measured on a comparable group of workers. One of the objectives of the seven-country case-control study of occupational exposure and brain cancer risk, INTEROCC, was to investigate the relationship of occupational exposure to electromagnetic fields (EMF) in different frequency ranges and brain cancer risk...
March 29, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28348204/hiv-persistence-through-division
#15
Lillian B Cohn, Michel C Nussenzweig
A long-lived latent reservoir for HIV-1 persists in CD4(+) T cells despite antiretroviral therapy and is the major barrier to cure. In this issue of JEM, Hosmane et al. show that T cell proliferation could explain the long-term persistence of this reservoir.
April 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28336744/association-of-respiratory-symptoms-and-asthma-with-occupational-exposures-findings-from-a-population-based-cross-sectional-survey-in-telemark-norway
#16
R Abrahamsen, A K M Fell, M V Svendsen, E Andersson, K Torén, P K Henneberger, J Kongerud
OBJECTIVES: The aim of this study was to estimate the prevalence of respiratory symptoms and physician-diagnosed asthma and assess the impact of current occupational exposure. DESIGN: Cross-sectional analyses of the prevalence of self-reported respiratory health and association with current occupational exposure in a random sample of the general population in Telemark County, Norway. SETTINGS: In 2013, a self-administered questionnaire was mailed to a random sample of the general population, aged 16-50, in Telemark, Norway...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28319818/a-task-based-assessment-of-parental-occupational-exposure-to-pesticides-and-childhood-acute-lymphoblastic-leukemia
#17
Robert B Gunier, Alice Kang, S Katharine Hammond, Kyndaron Reinier, C Suzanne Lea, Jeffrey S Chang, Monique Does, Ghislaine Scelo, Janice Kirsch, Vonda Crouse, Robert Cooper, Patricia Quinlan, Catherine Metayer
OBJECTIVES: Associations between parental occupational pesticide exposure and childhood acute lymphoblastic leukemia (ALL) vary across studies, likely due to different exposure assessment methodologies. METHODS: We assessed parental occupational pesticide exposure from the year before pregnancy to the child's third year of life for 669 children diagnosed with ALL and 1021 controls. We conducted expert rating using task-based job modules (JM) to estimate exposure to pesticides among farmer workers, gardeners, agricultural packers, and pesticide applicators...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28299449/contribution-of-job-exposure-matrices-for-exposure-assessment-in-occupational-safety-and-health-monitoring-systems-application-from-the-french-national-occupational-disease-surveillance-and-prevention-network
#18
Arnaud Florentin, Denis Zmirou-Navier, Christophe Paris
OBJECTIVES: To detect new hazards ("signals"), occupational health monitoring systems mostly rest on the description of exposures in the jobs held and on reports by medical doctors; these are subject to declarative bias. Our study aims to assess whether job-exposure matrices (JEMs) could be useful tools for signal detection by improving exposure reporting. METHODS: Using the French national occupational disease surveillance and prevention network (RNV3P) data from 2001 to 2011, we explored the associations between disease and exposure prevalence for 3 well-known pathology/exposure couples and for one debatable couple...
March 16, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28295002/-ultrastructural-characteristics-of-gap-junctions-in-human-glial-brain-tumors
#19
E Yu Kirichenko, A F Savchenko, D V Kozachenko, A E Matsionis, A K Logvinov
AIM: to conduct an electron microscopic study of intercellular communication in the samples of gemistocytic astrocytoma, oligodendroglioma, and glioblastoma. MATERIAL AND METHODS: Surgically resected tumor tissue fragments were fixed in 2.5% glutaraldehyde solution, afterfixed in 1% OsO4 solution, dehydrated, and embedded in epoxy resin. Ultrathin sections were examined using a Jem 1011 electron microscope (Jeol, Japan). RESULTS: Solitary and closely spaced gap junctions (GJs) formed by the thin processes that have the ultrastructure of an astroglial processes were identified in the astrocytoma samples...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28265305/the-10th-anniversary-of-the-publication-of-genes-and-environment-memoir-of-establishing-the-japanese-environmental-mutagen-society-and-a-proposal-for-a-new-collaborative-study-on-mutagenic-hormesis
#20
Shizuyo Sutou
The Japanese Environmental Mutagen Society (JEMS) was established in 1972 by 147 members, 11 of whom are still on the active list as of May 1, 2016. As one of them, I introduce some historic topics here. These include 1) establishment of JEMS, 2) the issue of 2-(2-furyl)-3-(3-nitro-2-furyl)acrylamide (AF-2), 3) the Mammalian Mutagenicity Study Group (MMS) and its achievements, and 4) the Collaborative Study Group of the Micronucleus Test (CSGMT) and its achievements. In addition to these historic matters, some of which are still ongoing, a new collaborative study is proposed on adaptive response or hormesis by mutagens...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
keyword
keyword
56093
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"