keyword
MENU ▼
Read by QxMD icon Read
search

JEMS

keyword
https://www.readbyqxmd.com/read/29158375/nsd3-keeps-irf3-active
#1
Takashi Mino, Osamu Takeuchi
In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.
November 20, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29150429/cgamp-a-tale-of-two-signals
#2
Teneema Kuriakose, Thirumala-Devi Kanneganti
In this issue of JEM, Swanson et al. (https://doi.org/10.1084/jem.20171749) report an unanticipated role for cGAMP in priming and activation of inflammasomes in addition to its well-characterized function as an endogenous second messenger inducing type I interferons in the cytosolic DNA-sensing pathway.
November 17, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29132097/the-development-of-a-new-artificial-model-of-a-finger-for-assessing-transmitted-vibrations
#3
Almaky Almagirby, Jem A Rongong, Matt J Carré
Prolonged exposure of the hand to tool-induced vibrations is associated with the occurrence of conditions such as vibration white finger. This study involves the development of a new artificial model that approximates both loading and vibration behaviour of the human finger. The layered system uses polypropylene "bones", encased in a cylinder of low modulus, room-temperature curing silicone gel (to replicate subcutaneous tissues), with an outer layer of latex (to replicate the dermis and epidermis). A protocol for manufacture was developed and dynamic mechanical analysis was carried out on a range of gels in order to choose a range close to the mechanical properties of the human finger...
November 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29128715/fabrication-of-ordered-metallic-glass-nanotube-arrays-for-label-free-biosensing-with-diffractive-reflectance
#4
Wei-Ting Chen, Shao-Sian Li, Jinn P Chu, Kuei Chih Feng, Jem-Kun Chen
In this study, a photoresist template with well-defined contact hole array was fabricated, to which radio frequency magnetron sputtering process was then applied to deposit an alloyed Zr55Cu30Al10Ni5 target, and finally resulted in ordered metallic glass nanotube (MGNT) arrays after removal of the photoresist template. The thickness of the MGNT walls increased from 98 to 126nm upon increasing the deposition time from 225 to 675s. The wall thickness of the MGNT arrays also increased while the dimensions of MGNT reduced under the same deposition condition...
October 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29115764/development-of-a-clinical-transition-pathway-for-adolescents-in-the-netherlands
#5
Margot Walter, Johanna Mw Hazes, Radboud Jem Dolhain, Philomine van Pelt, Annette van Dijk, Sylvia Kamphuis
AIMS: To explore how young people with juvenile-onset rheumatic and musculoskeletal diseases (jRMDs) and their parent(s) experience care during preparation for the upcoming transfer to adult services, and to develop a clinical transition pathway. METHOD: A survey was conducted with 32 young people aged between 14 and 20 years with jRMDs, and their parents ( n =33), treated at the department of paediatric rheumatology in a tertiary care children's hospital in the Netherlands...
November 7, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29095802/occupational-exposure-to-vapor-gas-dust-and-fumes-in-a-cohort-of-rural-adults-in-iowa-compared-with-a-cohort-of-urban-adults
#6
COMPARATIVE STUDY
Brent C Doney, Paul K Henneberger, Michael J Humann, Xiaoming Liang, Kevin M Kelly, Jean M Cox-Ganser
PROBLEM/CONDITION: Many rural residents work in the field of agriculture; however, employment in nonagricultural jobs also is common. Because previous studies in rural communities often have focused on agricultural workers, much less is known about the occupational exposures in other types of jobs in rural settings. Characterizing airborne occupational exposures that can contribute to respiratory diseases is important so that differences between rural and urban working populations can be assessed...
November 3, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29079609/investigation-of-the-international-comparability-of-population-based-routine-hospital-data-set-derived-comorbidity-scores-for-patients-with-lung-cancer
#7
Margreet Lüchtenborg, Eva J A Morris, Daniela Tataru, Victoria H Coupland, Andrew Smith, Roger L Milne, Luc Te Marvelde, Deborah Baker, Jane Young, Donna Turner, Diane Nishri, Craig Earle, Lorraine Shack, Anna Gavin, Deirdre Fitzpatrick, Conan Donnelly, Yulan Lin, Bjorn Moller, David H Brewster, Andrew Deas, Dyfed W Huws, Ceri White, Janet Warlow, Jem Rashbass, Michael D Peake
INTRODUCTION: The International Cancer Benchmarking Partnership (ICBP) identified significant international differences in lung cancer survival. Differing levels of comorbid disease across ICBP countries has been suggested as a potential explanation of this variation but, to date, no studies have quantified its impact. This study investigated whether comparable, robust comorbidity scores can be derived from the different routine population-based cancer data sets available in the ICBP jurisdictions and, if so, use them to quantify international variation in comorbidity and determine its influence on outcome...
October 27, 2017: Thorax
https://www.readbyqxmd.com/read/29066522/development-and-progress-of-the-national-congenital-anomaly-and-rare-disease-registration-service
#8
Sarah Stevens, Nicola Miller, Jem Rashbass
No abstract text is available yet for this article.
October 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29064482/development-of-a-total-hydrocarbon-ordinal-job-exposure-matrix-for-workers-responding-to-the-deepwater-horizon-disaster-the-gulf-study
#9
Patricia A Stewart, Mark R Stenzel, Gurumurthy Ramachandran, Sudipto Banerjee, Tran B Huynh, Caroline P Groth, Richard K Kwok, Aaron Blair, Lawrence S Engel, Dale P Sandler
The GuLF STUDY is a cohort study investigating the health of workers who responded to the Deepwater Horizon oil spill in the Gulf of Mexico in 2010. The objective of this effort was to develop an ordinal job-exposure matrix (JEM) of airborne total hydrocarbons (THC), dispersants, and particulates to estimate study participants' exposures. Information was collected on participants' spill-related tasks. A JEM of exposure groups (EGs) was developed from tasks and THC air measurements taken during and after the spill using relevant exposure determinants...
October 18, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29061692/a-new-lead-to-nlrp3-inhibition
#10
Mohamed Lamkanfi, Vishva M Dixit
The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).
November 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29021869/a-perspective-of-genes-and-environment-for-the-development-of-environmental-mutagen-research-in-asia
#11
EDITORIAL
Takashi Yagi
Two years have passed since the Japanese Environmental Society (JEMS) made the official journal Genes and Environment (G&E) open access. Current subjects on environmental mutagen research to further advance this field are described herein, and the roles of JEMS and G&E are discussed. Various important subjects are being investigated in current research fields such as severe environmental pollution in Asian countries; the identification of new hazardous substances and elucidation of mutation mechanisms using newly developed techniques; the development of new genotoxicity assays including in silico predictions using information technology and artificial intelligence as well as bioassays...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/29018075/prospective-investigation-of-pesticide-applicators-health-pipah-study-a-cohort-study-of-professional-pesticide-users-in-great-britain
#12
Anne-Helen Harding, David Fox, Yiqun Chen, Neil Pearce, David Fishwick, Gillian Frost
PURPOSE: The purpose of the study is to monitor the exposure and health of workers in Great Britain who use pesticides as a part of their job, and to gain a better understanding of the relationship between long-term exposure to pesticides and health. PARTICIPANTS: Study participants are professional pesticide users who are certified in the safe use of pesticides or who were born before 1965 and apply pesticides under 'grandfather rights'. Overall response rate was 20%; participants are mostly male (98%) and the average age is 54 years, ranging from 17 to over 80 years...
October 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28987020/cardiac-and-hemodynamic-influence-on-carotid-artery-longitudinal-wall-motion
#13
Jason S Au, Paula A Bochnak, Sydney E Valentino, Jem L Cheng, Eric J Stöhr, Maureen J MacDonald
Carotid artery longitudinal wall motion (CALM) has recently attracted interest as an indicator of arterial health; however, the regulation of CALM is poorly understood. We conducted a series of studies aimed at manipulating pulse pressure (PP), left ventricular (LV) motion, and carotid shear rate, which have been previously suggested to regulate various components of CALM pattern and magnitude. To determine the regulatory influences on CALM, fifteen healthy males (22 ± 2 years) were exposed to three acute interventions: the Serial Subtraction Test (SST), the Cold Pressor Test (CPT), and exposure to sublingual nitroglycerine (NTG)...
October 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28982368/fabrication-of-device-with-poly-n-isopropylacrylamide-b-ssdna-copolymer-brush-for-resistivity-study
#14
Yi-Zu Liu, May-Show Chen, Chih-Chia Cheng, Shih-Hsun Chen, Jem-Kun Chen
In this study, we grafted bromo-terminated poly(N-isopropylacrylamide) (PNIPAAm) brushes onto thin gold films deposited on silicon, and then reacted with NaN3 to produce azido-terminated PNIPAAm brushes. A probe sequence of single-stranded DNA (ssDNA) with a 4-pentynoic acid succinimidyl ester unit was grafted onto the azido-terminated PNIPAAm brushes through a click reaction, resulting in the formation of block copolymer brushes. The PNIPAAm-b-ssDNA copolymer brushes formed supramolecular complexes stabilized by bio-multiple hydrogen bonds (BMHBs), which enhanced the proton transfer and thereby decreased the resistivity of the structures...
October 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28976133/angiotensin-receptor-signaling-and-prostate-tumor-growth-in-mice
#15
Jem Scott-Emuakpor, Emma Allot, Stacy A Johnson, Lauren E Howard, Everardo Macias, Stephen J Freedland, Susan B Gurley
The renin-angiotensin system, through its type 1 and type 2 angiotensin receptors (AT1R and AT2R, respectively) may have a role in prostate cancer. The objective of this pilot study was to explore that potential role by determining whether the AT1R blocker, losartan, would reduce the growth of LAPC-4 prostate cancer xenografts in nude mice. We also evaluated the tumor growth effects of using angiotensin II to activate both AT1R and AT2R simultaneously. Our data showed that losartan decreased tumor volumes by 56% versus control...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28975928/meta-analysis-of-job-exposure-matrix-data-from-multiple-sources
#16
Wenting Cheng, Benjamin Roberts, Bhramar Mukherjee, Richard L Neitzel
The objectives of this study were to determine the heterogeneity of data sources used to construct a job-exposure matrix (JEM) for occupational noise, and to calculate pooled exposure estimates for different job titles using different sources. The JEM was populated with measurements from government databases, private industry, and the published literature. Data were organized by job title using the US standard occupational classification (SOC). Using data from the literature as prior information, adjusted mean exposure was calculated for both the government and industry data following a simple Bayesian approach...
October 4, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28973841/airborne-occupational-exposures-and-risk-of-developing-rheumatoid-arthritis-a-job-exposure-matrix-approach-in-a-swedish-population-based-case-control-study
#17
Anna Ilar, Lars Alfredsson, Pernilla Wiebert, Lars Klareskog, Camilla Bengtsson
Professor Alexis Descatha suggests that we should have used job-exposure matrices (JEM) to understand the underlying increased risks we noted between certain occupations and risk of rheumatoid arthritis (RA) in our study Occupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study (1). This article is protected by copyright. All rights reserved.
October 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28930297/estimated-radiation-exposure-of-german-commercial-airline-cabin-crew-in-the-years-1960-2003-modeled-using-dose-registry-data-for-2004-2015
#18
Daniel Wollschläger, Gaël Paul Hammer, Thomas Schafft, Steffen Dreger, Maria Blettner, Hajo Zeeb
Exposure to ionizing radiation of cosmic origin is an occupational risk factor in commercial aircrew. In a historic cohort of 26,774 German aircrew, radiation exposure was previously estimated only for cockpit crew using a job-exposure matrix (JEM). Here, a new method for retrospectively estimating cabin crew dose is developed. The German Federal Radiation Registry (SSR) documents individual monthly effective doses for all aircrew. SSR-provided doses on 12,941 aircrew from 2004 to 2015 were used to model cabin crew dose as a function of age, sex, job category, solar activity, and male pilots' dose; the mean annual effective dose was 2...
September 20, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28910824/occupational-solvent-exposure-and-risk-of-glioma-in-the-interocc-study
#19
Geza Benke, Michelle C Turner, Sarah Fleming, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Maria Blettner, Martine Hours, Daniel Krewski, David McLean, Marie-Elise Parent, Siegal Sadetzki, Klaus Schlaefer, Brigitte Schlehofer, Jack Siemiatycki, Martie van Tongeren, Elisabeth Cardis
BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade...
October 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28910766/light-field-compression-with-disparity-guided-sparse-coding-based-on-structural-key-views
#20
Jie Chen, Junhui Hou, Lap-Pui Chau
Recent imaging technologies are rapidly evolving for sampling richer and more immersive representations of the 3D world. One of the emerging technologies is light field (LF) cameras based on micro-lens arrays. To record the directional information of the light rays, a much larger storage space and transmission bandwidth are required by a LF image as compared with a conventional 2D image of similar spatial dimension. Hence, the compression of LF data becomes a vital part of its application. In this paper, we propose a LF codec with disparity guided Sparse Coding over a learned perspective-shifted LF dictionary based on selected Structural Key Views (SC-SKV)...
September 8, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
keyword
keyword
56093
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"