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https://www.readbyqxmd.com/read/29786576/the-histological-and-electron-microscopic-study-of-the-parotid-salivary-gland-in-dehydrated-rats-of-different-ages
#1
Denys P Biletskyy, Oleg A Ustiansky, Olena S Maksymova, Pavel A Moskalenko, Alexey A Tymoshenko, Anna S Degtyarenko, Viktoriia Yu Harbuzova, Yevhen I Dubovyk, Andrii P Voznyi, Gennadii F Tkach
OBJECTIVE: Introduction: Water-salt metabolism disorders is one of the main factor of salivary gland pathology development. The aim: To study the morphological structure of the parotid salivary gland of young, mature and old rats at micro- and ultrastructural levels under water deprivation. PATIENTS AND METHODS: Materials and methods: The experiment was carried out on thirty six laboratory male rats of different ages (young, mature and old). The rats of the control group received normal volume of drinking water...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29780365/editorial-the-search-for-biological-active-agent-s-from-actinobacteria
#2
EDITORIAL
Learn-Han Lee, Kok-Gan Chan, Jem Stach, Elizabeth M H Wellington, Bey-Hing Goh
No abstract text is available yet for this article.
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29764914/less-cholesterol-means-better-tumor-killing-for-cytotoxic-t9-cells
#3
Brad Griesenauer, Sophie Paczesny
In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.
May 15, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29691302/repressing-the-repressor-ezh2-mediates-macrophage-activation
#4
Annette E Neele, Menno P J de Winther
In this issue of JEM , Zhang et al. (https://doi.org/10.1084/jem.20171417) show that the suppressive epigenetic enzyme Ezh2 is an important regulator of macrophage activation. The absence of Ezh2 leads to reduced cytokine secretion and suppresses macrophage-dependent disease development. They identify the antiinflammatory factor Socs3 as an important target for Ezh2 and thus show that regulation of suppressive histone modifications controls macrophage activation in disease.
April 24, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29685951/dual-therapy-for-a%C3%AE-amyloidosis-in-ad-a-successful-one-two-combo
#5
Tirth K Patel, David M Holtzman
In this issue, Chiang et al. (https://doi.org/10.1084/jem.20171484) make a notable contribution to Alzheimer disease (AD) therapeutics in a thorough and rigorous study demonstrating superior efficacy of dual therapy against Aβ in a mouse model of amyloid β deposition.
April 23, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29677448/self-assembled-ph-responsive-polymeric-micelles-for-highly-efficient-non-cytotoxic-delivery-of-doxorubicin-chemotherapy-to-inhibit-macrophage-activation-in-vitro-investigation
#6
Zhi-Sheng Liao, Shan-You Huang, Jyun-Jie Huang, Jem-Kun Chen, Ai-Wei Lee, Juin-Yih Lai, Duu-Jong Lee, Chih-Chia Cheng
Self-assembled pH-responsive polymeric micelles, a combination of hydrophilic poly(ethylene glycol) segments and hydrogen bonding interactions within a biocompatible polyurethane substrate, can spontaneously self-assemble into highly controlled, nanosized micelles in aqueous solution. These newly-developed micelles exhibit excellent pH-responsive behavior and biocompatibility, highly controlled drug (doxorubicin; DOX) release behavior and high drug encapsulation stability in different aqueous environments, making the micelles highly attractive potential candidates for safer, more effective drug delivery in applications such as cancer chemotherapy...
April 20, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29667308/diagnosis-and-management-of-giant-cell-arteritis-an-asia-pacific-perspective
#7
Jem V Ninan, Susan Lester, Catherine L Hill
No abstract text is available yet for this article.
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29650699/update-of-an-occupational-asthma-specific-job-exposure-matrix-to-assess-exposure-to-30-specific-agents
#8
Nicole Le Moual, Jan-Paul Zock, Orianne Dumas, Theodore Lytras, Eva Andersson, Linnéa Lillienberg, Vivi Schlünssen, Geza Benke, Hans Kromhout
OBJECTIVES: We aimed to update an asthmagen job exposure matrix (JEM) developed in the late 1990s. Main reasons were: the number of suspected and recognised asthmagens has since tripled; understanding of the aetiological role of irritants in asthma and methodological insights in application of JEMs have emerged in the period. METHODS: For each agent of the new occupational asthma-specific JEM (OAsJEM), a working group of three experts out of eight evaluated exposure for each International Standard Classification of Occupations, 1988 (ISCO-88) job code into three categories: 'high' (high probability of exposure and moderate-to-high intensity), 'medium' (low-to-moderate probability or low intensity) and 'unexposed'...
April 12, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29599164/incident-cts-in-a-large-pooled-cohort-study-associations-obtained-by-a-job-exposure-matrix-versus-associations-obtained-from-observed-exposures
#9
Ann Marie Dale, Christine C Ekenga, Skye Buckner-Petty, Linda Merlino, Matthew S Thiese, Stephen Bao, Alysha Rose Meyers, Carisa Harris-Adamson, Jay Kapellusch, Ellen A Eisen, Fred Gerr, Kurt T Hegmann, Barbara Silverstein, Arun Garg, David Rempel, Angelique Zeringue, Bradley A Evanoff
BACKGROUND: There is growing use of a job exposure matrix (JEM) to provide exposure estimates in studies of work-related musculoskeletal disorders; few studies have examined the validity of such estimates, nor did compare associations obtained with a JEM with those obtained using other exposures. OBJECTIVE: This study estimated upper extremity exposures using a JEM derived from a publicly available data set (Occupational Network, O*NET), and compared exposure-disease associations for incident carpal tunnel syndrome (CTS) with those obtained using observed physical exposure measures in a large prospective study...
March 29, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29520473/study-of-the-validity-of-a-job-exposure-matrix-for-the-job-strain-model-factors-an-update-and-a-study-of-changes-over-time
#10
Isabelle Niedhammer, Allison Milner, Anthony D LaMontagne, Jean-François Chastang
OBJECTIVES: The objectives of the study were to construct a job-exposure matrix (JEM) for psychosocial work factors of the job strain model, to evaluate its validity, and to compare the results over time. METHODS: The study was based on national representative data of the French working population with samples of 46,962 employees (2010 SUMER survey) and 24,486 employees (2003 SUMER survey). Psychosocial work factors included the job strain model factors (Job Content Questionnaire): psychological demands, decision latitude, social support, job strain and iso-strain...
March 8, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29507056/tak1ng-control-tak1-restrains-nlrp3-activation
#11
Matthew Stephen Mangan, Eicke Latz
In this issue of JEM, Malireddi et al. (https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its potential function as an anticancer drug treatment.
April 2, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29449308/predicting-aid-off-targets-a-step-forward
#12
Claude-Agnès Reynaud, Jean-Claude Weill
In this issue of JEM, Álvarez-Prado et al. (https://doi.org/10.1084/jem.20171738) designed a DNA capture library allowing them to identify 275 genes targeted by AID in mouse germinal center B cells. Using the molecular features of these genes to feed a machine-learning algorithm, they determined that high-density RNA PolII and Spt5 binding-found in 2.3% of the genes-are the best predictors of AID specificity.
March 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29440361/defusing-inflammasomes
#13
Andrew Sandstrom, Russell E Vance
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
March 5, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29366893/molecular-characterization-of-cry1d-133-toxin-from-bacillus-thuringiensis-strain-hd133-and-its-toxicity-against-spodoptera-littoralis
#14
Dalel BenFarhat-Touzri, Fatma Driss, Sonia Jemli, Slim Tounsi
Bacillus thuringiensis subsp. aizawai strain HD133, known by its effectiveness against Spodoptera species, produces bipyramidal crystals encompassing the insecticidal proteins Cry1Ab, Cry1Ca and Cry1D-133 in the proportions 60:37:3, respectively. In this study, we dealt with the relevance of the low rate of Cry1D-133. The cry1D-133 gene from HD133 was cloned and sequenced. Both nucleotide and amino acid sequence similarity analyses with the cry1D genes available in the GenBank database revealed that cry1D-133 is a new variant of cry1Da-type genes with 99% identity with cry1Da1...
June 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29342223/development-of-a-job-exposure-matrix-for-noise-in-the-swedish-soft-tissue-paper-industry
#15
Richard Lee Neitzel, Marianne Andersson, Helena Eriksson, Kjell Torén, Eva Andersson
Objectives: Noise exposure is a common occupational hazard, but has not been sufficiently characterized in paper mills. We developed a job-exposure matrix (JEM) for noise exposure for use in estimating exposures among Swedish soft tissue paper mill workers. Methods: We used a combination of area and personal dosimetry noise exposure measurements made at four soft tissue paper mills by industry and research staff between 1977 and 2013 to estimate noise exposures by department, location, and job title...
December 16, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29338768/binary-blend-fibber-based-capture-assay-of-circulating-tumor-cells-for-clinical-diagnosis-of-colorectal-cancer
#16
Ai-Wei Lee, Fu-Xiang Lin, Po-Li Wei, Guo Jian-Wei, Jem-Kun Chen
BACKGROUND: In addition to conventional approaches, detecting and characterizing CTCs in patient blood allows for early diagnosis of cancer metastasis. METHODS: We blended poly(ethylene oxide) (PEO) into nylon-6 through electrospinning to generate a fibrous matbased circulating tumour cells (CTCs) assay. The contents of nylon-6 and PEO in the electrospun blend fibrous mats (EBFMs) were optimized to facilitate high cell-substrate affinity and low leukocyte adsorption...
January 16, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29323398/night-shift-work-and-hematological-cancers-a-population-based-case-control-study-in-three-nordic-countries
#17
Madar Talibov, Eero Pukkala, Jan Ivar Martinsen, Laufey Tryggvadottir, Elisabete Weiderpass, Johnni Hansen
Objective The aim of this case-control study was to assess the effect of night-shift work on the risk of hematological cancers. Methods The study included 39 371 leukemia, 56 713 non-Hodgkin lymphoma, 9322 Hodgkin lymphoma, and 26 188 multiple myeloma cases diagnosed between 1961 and 2005 in Finland, Sweden, and Iceland. Five controls for each case were selected from the Nordic Occupational Cancer Study (NOCCA) cohort, matched by year of birth, sex and country. Night-shift exposure was assessed by using the NOCCA job-exposure matrix (JEM)...
January 11, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29305928/anti-proliferative-activity-of-biochanin-a-in-human-osteosarcoma-cells-via-mitochondrial-involved-apoptosis
#18
Yen-Nien Hsu, Huey-Wen Shyu, Tsui-Wen Hu, Jou-Pei Yeh, Ya-Wen Lin, Ling-Yi Lee, Yao-Tsung Yeh, Hong-Ying Dai, Daw-Shyong Perng, Shu-Hui Su, Yu-Hsuan Huang, Shu-Jem Su
Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. The results indicate that biochanin A inhibited cell growth and colony formation in a dose-dependent manner with a minimal toxicity to normal cells. The combination of doxorubicin and biochanin A could synergistically inhibit osteosarcoma cell growth...
February 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29300061/fabrication-of-an-artificial-nanosucker-device-with-a-large-area-nanotube-array-of-metallic-glass
#19
Wei-Ting Chen, Karthikeyan Manivannan, Chia-Chi Yu, Jinn P Chu, Jem-Kun Chen
The concurrent attachment and detachment movements of geckos on virtually any type of surface via their foot pads have inspired us to develop a thermal device with numerous arrangements of a multi-layer thin film together with electrodes that can help modify the temperature of the surface via application of a voltage. A sequential fabrication process was employed on a large-scale integration to generate well-defined contact hole arrays of photoresist for use as templates on the electrode-based device. The photoresist templates were then subjected to sputter deposition of the metallic glass Zr55 Cu30 Al10 Ni5 ...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29275242/maternal-cumulative-exposure-to-extremely-low-frequency-electromagnetic-fields-and-pregnancy-outcomes-in-the-elfe-cohort
#20
L Migault, C Piel, C Carles, F Delva, A Lacourt, E Cardis, C Zaros, R de Seze, I Baldi, G Bouvier
OBJECTIVES: To study the relations between maternal cumulative exposure to extremely low frequency electromagnetic fields (ELF EMF) and the risk of moderate prematurity and small for gestational age within the Elfe cohort. METHODS: The Elfe study included 18,329 infants born at 33weeks of gestation or more in France in 2011 and was designed to follow the children until 20years of age. Gestational age and anthropometric data at birth were collected in medical records and small for gestational age was defined according to a French customized growth standard...
December 20, 2017: Environment International
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