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https://www.readbyqxmd.com/read/27896686/blastococcus-colisei-sp-nov-isolated-from-an-archaeological-amphitheatre
#1
Karima Hezbri, Imen Nouioui, Manfred Rohde, Peter Schumann, Maher Gtari, Hans-Peter Klenk, Maria Del Carmen Montero-Calasanz, Faten Ghodhbane-Gtari
The taxonomic position of an actinobacterial isolate, designated strain BMG 822(T), isolated from limestone from the Amphitheater of El Jem (Coliseum Thysdrus), Tunisia, was established using a polyphasic approach. Strain BMG 822(T) was found to grow well at 30 °C and pH 6.5-8.0, and to be coral-coloured, Gram-positive, catalase and oxidase negative. Whole cell hydrolysates contained meso-diaminopimelic acid as the diagnostic diamino acid, glucose, galactose and ribose. The phospholipids detected were diphosphatidylglycerol, phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, hydroxy-phosphatidylethanolamine, an unidentified glycophospholipid and six unidentified phospholipids...
November 28, 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27881735/therapy-activated-stromal-cells-can-dictate-tumor-fate
#2
Robert S Kerbel, Yuval Shaked
In this issue of JEM, Chan et al. describe a novel way by which an investigational form of chemotherapy known as low-dose metronomic chemotherapy can inhibit tumor growth, which also has therapeutic implications for targeting tumor-initiating cells (TICs), the tumor stroma, and chemokine receptors, as well as invasion and metastasis.
November 23, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27856424/eradication-of-canine-diffuse-large-b-cell-lymphoma-in-a-murine-xenograft-model-with-cd47-blockade-and-anti-cd20
#3
Kipp Weiskopf, Katie L Anderson, Daisuke Ito, Peter J Schnorr, Hirotaka Tomiyasu, Aaron M Ring, Kristin Bloink, Jem Efe, Sarah Rue, David Lowery, Amira Barkal, Susan Prohaska, Kelly M McKenna, Ingrid Cornax, Timothy D O'Brien, M Gerard O'Sullivan, Irving L Weissman, Jaime F Modiano
Cancer immunotherapies hold much promise, but their potential in veterinary settings has not yet been fully appreciated. Canine lymphomas are among the most common tumors of dogs and bear remarkable similarity to human disease. In this study, we examined the combination of CD47 blockade with anti-CD20 passive immunotherapy for canine lymphoma. The CD47/SIRPα axis is an immune checkpoint that regulates macrophage activation. In humans, CD47 is expressed on cancer cells and enables evasion from phagocytosis...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27842581/impact-of-occupational-exposures-on-exacerbation-of-asthma-a-population-based-asthma-cohort-study
#4
Jeong-Lim Kim, Paul K Henneberger, Susanna Lohman, Anna-Carin Olin, Anna Dahlman-Höglund, Eva Andersson, Kjell Torén, Mathias Holm
BACKGROUND: Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study investigated the association between asthma exacerbations and occupational exposures. METHODS: The study comprised all currently working adults (n = 1356) who reported ever asthma in prior population-based cohorts. All subjects completed a questionnaire about exposures, occupations and exacerbations of asthma...
November 15, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27819519/association-of-the-ifn-%C3%AE-874a-t-genetic-polymorphism-with-paranoid-schizophrenia-in-tunisian-population
#5
Achraf Jemli, Awatef Eshili, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, George Juckel, Besma Bel Hadj Jrad Tensaout
Since growing evidence suggests a significant role of chronic low-grade inflammation in the physiopathology of schizophrenia, we have hypothesized that functional genetic variant of the IFN gamma (IFN-γ; +874A/T; rs2430561) gene may be involved in the predisposition to schizophrenia. This research is based on a case-control study which aims to identify whether polymorphism of the IFN-γ gene is a risk factor for the development of schizophrenia. The RFLP-PCR genotyping of the IFN-γ gene was conducted on a Tunisian population composed of 218 patients and 162 controls...
November 7, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27777373/occupational-exposures-and-chronic-obstructive-pulmonary-disease-copd-comparison-of-a-copd-specific-job-exposure-matrix-and-expert-evaluated-occupational-exposures
#6
Laura Kurth, Brent Doney, Sheila Weinmann
OBJECTIVES: To compare the occupational exposure levels assigned by our National Institute for Occupational Safety and Health chronic obstructive pulmonary disease-specific job exposure matrix (NIOSH COPD JEM) and by expert evaluation of detailed occupational information for various jobs held by members of an integrated health plan in the Northwest USA. METHODS: We analysed data from a prior study examining COPD and occupational exposures. Jobs were assigned exposure levels using 2 methods: (1) the COPD JEM and (2) expert evaluation...
October 24, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27749985/a-validation-study-associating-glutaminase-promoter-variations-with-hepatic-encephalopathy-in-east-asian-populations
#7
Jem Ma Ahn, Chang Ha Kim, Soon Ho Um, Kyung Mee Kim, Tae Hyung Kim, Sun Young Yim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu
BACKGROUND AND AIM: In a recent study, microsatellite variations (GCA tandem repeats) in the promoter region of the (kidney-type) glutaminase gene were associated with the development of hepatic encephalopathy (HE) in Spanish patients with cirrhosis. The objective of this study was to validate the relation between microsatellite variations in the glutaminase promoter region and the development of overt HE in Korean patients with liver cirrhosis. METHODS: We performed a prospective cohort study of 154 cirrhotic patients who underwent a glutaminase microsatellite study without previous overt HE history at baseline...
October 17, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27722277/multinuclear-nmr-as-a-tool-for-studying-local-order-and-dynamics-in-ch3nh3pbx3-x-cl-br-i-hybrid-perovskites
#8
Claire Roiland, Gaelle Trippé-Allard, Khaoula Jemli, Bruno Alonso, Jean-Claude Ameline, Régis Gautier, Thierry Bataille, Laurent Le Pollès, Emmanuelle Deleporte, Jacky Even, Claudine Katan
We report on (207)Pb, (79)Br, (14)N, (1)H, (13)C and (2)H NMR experiments for studying the local order and dynamics in hybrid perovskite lattices. (207)Pb NMR experiments conducted at room temperature on a series of MAPbX3 compounds (MA = CH3NH3(+); X = Cl, Br and I) showed that the isotropic (207)Pb NMR shift is strongly dependent on the nature of the halogen ions. Therefore (207)Pb NMR appears to be a very promising tool for the characterisation of local order in mixed halogen hybrid perovskites. (207)Pb NMR on MAPbBr2I served as a proof of concept...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27693243/benzyl-isothiocyanate-promotes-apoptosis-of-oral-cancer-cells-via-an-acute-redox-stress-mediated-dna-damage-response
#9
Yao-Tsung Yeh, Yen-Nien Hsu, Sheng-Yun Huang, Jian-Sheng Lin, Zi-Feng Chen, Nan-Haw Chow, Shu-Hui Su, Huey-Wen Shyu, Ching-Chiang Lin, Wu-Tein Huang, Hua Yeh, Yu-Chia Chih, Yu-Hsuan Huang, Shu-Jem Su
Benzyl isothiocyanate (BITC) is a cruciferous vegetable-derived compound with anticancer properties in human cancer cells. However, its anticancer potential and underlying mechanisms remain absent in human oral cancer cells. Results indicate that BITC inhibits growth, promotes G2/M phase arrest and triggers apoptosis of OC2 cells with a minimal toxicity to normal cells. BITC-induced cell death was completely prevented by pretreatment with thiol-containing redox compounds including N-acetyl-l-cysteine (NAC), glutathione (GSH), dithiothreitol, and 2-mercaptoethanol, but not free radical scavengers mito-TEMPO, catalase, apocynin, l-NAME and mannitol...
September 28, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27687310/vectorized-gene-therapy-of-liver-tumors-proof-of-concept-of-tg4023-mva-fcu1-in-combination-with-flucytosine
#10
F Husseini, J-P Delord, C Fournel-Federico, J Guitton, P Erbs, M Homerin, C Halluard, C Jemming, C Orange, J-M Limacher, J-E Kurtz
BACKGROUND: TG4023 is a modified vaccinia virus Ankara (MVA) containing the yeast-originated transgene FCU1, expressing cytosine deaminase and uracil phosphoribosyltransferase enzymes that transform the prodrug flucytosine (5-FC) into cytotoxic 5-fluorouracil (5-FU) and 5-fluorouridine-5'-monophosphate (5-FUMP), respectively. This first-in-human study aimed to assess the maximum tolerated dose (MTD) of intra-tumoral (IT) TG4023 and the safety, feasibility, and proof-of-concept (PoC) of TG4023/5-FC combination to deliver high 5-FU concentrations in tumors...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27662808/rapid-fabrication-of-carbon-quantum-dots-as-multifunctional-nanovehicles-for-dual-modal-targeted-imaging-and-chemotherapy
#11
Sheng-Hui Chiu, Gangaraju Gedda, Wubshet Mekonnen Girma, Jem-Kun Chen, Yong-Chien Ling, Anil V Ghule, Keng-Liang Ou, Jia-Yaw Chang
: Herein, we synthesized an S, N, and Gd tri-element doped magnetofluorescent carbon quantum dots (GdNS@CQDs) within 10min by using a one-pot microwave method. Our results showed that these magnetofluorescent GdNS@CQDs have excellent fluorescent and magnetic properties. Moreover, GdNS@CQDs exhibited high stability at physiological conditions and ionic strength. These magnetofluorescent GdNS@CQDs were conjugated with a folic acid, denoted as FA-GdNS@CQDs, for targeting dual modal fluorescence/magnetic resonance (MR) imaging...
September 20, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27651695/oncological-safety-of-breast-conservation-surgery-in-young-females
#12
Madhu Muralee, Arun Peter Mathew, Kurian Cherian, K Chandramohan, Paul Augustine, Jem Prabhakar, Iqbal Ahamed
Breast conservation surgery (BCS) is the standard of care in early breast cancer. The oncological safety of this procedure has been proven beyond doubt in several randomised control trials. But there are concerns regarding the safety of this procedure in young females. The concern is regarding increased risk of local recurrence. This issue has not been addressed in any major trial. In this prospective study we intend to look into the oncological safety of BCS in young patients who are less than forty years of age...
September 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27639492/supermolecules-of-poly-n-isopropylacrylamide-complexating-herring-sperm-dna-with-bio-multiple-hydrogen-bonding
#13
Ai-Wei Lee, Cheng-Chen Hsu, Yi-Zu Liu, Po-Li Wei, Jem-Kun Chen
In this study we used the poly(N-isopropylacrylamide) (PNIPAAm) as a medium to blend with an organic DNA, herring sperm DNA (HSD), to generate PNIPAAm-HSD supramolecular complexes. Bio-multiple hydrogen bonding (BMHB) between PNIPAAm and HSD was investigated that changed the temperature responsiveness of PNIPAAm relatively to the HSD concentrations. With blending the HSD into PNIPAAm matrix, the phase separation in solution is completely opposite from that of neat PNIPAAm. Surface property in static water contact angle (SWCA) is also opposite from that of pure PNIPAAm upon increasing HSD content over 60%...
September 12, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27599138/30-day-mortality-after-systemic-anticancer-treatment-for-breast-and-lung-cancer-in-england-a-population-based-observational-study
#14
Michael Wallington, Emma B Saxon, Martine Bomb, Rebecca Smittenaar, Matthew Wickenden, Sean McPhail, Jem Rashbass, David Chao, John Dewar, Denis Talbot, Michael Peake, Timothy Perren, Charles Wilson, David Dodwell
BACKGROUND: 30-day mortality might be a useful indicator of avoidable harm to patients from systemic anticancer treatments, but data for this indicator are limited. The Systemic Anti-Cancer Therapy (SACT) dataset collated by Public Health England allows the assessment of factors affecting 30-day mortality in a national patient population. The aim of this first study based on the SACT dataset was to establish national 30-day mortality benchmarks for breast and lung cancer patients receiving SACT in England, and to start to identify where patient care could be improved...
September 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27588156/contribution-to-regulatory-science-and-a-next-challenge-of-the-japanese-environmental-mutagen-society-jems
#15
Yoshifumi Uno
Many members of The Japanese Environmental Mutagen Society (JEMS) have significantly contributed to guidelines on chemical genotoxicity. The guidelines have been useful for the hazard identification and risk assessment of genotoxic chemicals. However, risk assessors and developers of drugs and other commercial products might eliminate beneficial chemicals from further development simply based on positive results of genotoxicity testing. Experts in the field of genotoxicity should better characterize the biological significance of genotoxicants and more correctly assess human risk...
2016: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/27573055/toxoplasma-gondii-infection-in-schizophrenia-and-associated-clinical-features
#16
Awatef Esshili, Sihem Thabet, Achraf Jemli, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, Georg Juckel, Hamouda Babba, Besma Bel Hadj Jrad
The belief that latent toxoplasmosis is asymptomatic has been questioned, in particular due to the repeated highlighted link between the Toxoplasma gondii infection and an increased incidence of schizophrenia. However, to understand this relationship, the effect of infection with Toxoplasma gondii on the severity of schizophrenia has been poorly studied. Our work focused on comparing the prevalence of Toxoplasma infection between schizophrenic patients and healthy controls, as well as comparing the clinical features and the demographic characteristics between Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27566782/development-of-a-job-task-exposure-matrix-to-assess-occupational-exposure-to-disinfectants-among-us-nurses
#17
C Quinot, O Dumas, P K Henneberger, R Varraso, A S Wiley, F E Speizer, M Goldberg, J P Zock, C A Camargo, N Le Moual
OBJECTIVES: Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. To evaluate disinfectant exposures, we designed job-exposure (JEM) and job-task-exposure (JTEM) matrices, which are thought to be less prone to differential misclassification bias than self-reported exposure. We then compared the three assessment methods: self-reported exposure, JEM and JTEM. METHODS: Disinfectant use was assessed by an occupational questionnaire in 9073 US female registered nurses without asthma, aged 49-68 years, drawn from the Nurses' Health Study II...
August 26, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27563937/ifngr2-genetic-polymorphism-associated-with-sex-specific-paranoid-schizophrenia-risk
#18
Achraf Jemli, Oumaima Inoubli, Fatma Trifa, Anouar Mechri, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad
BACKGROUND: Considering current scientific evidence about the significant role of chronic low grade inflammation in the physiopathology of schizophrenia, it has been hypothesized that changes in pro-inflammatory cytokines such as interferon gamma may have a significant role in the predisposition to schizophrenia. AIM: This study focuses on identifying whether the functional polymorphism of interferon gamma receptor 2 (IFNGR2) is a risk factor for the development of schizophrenia...
August 26, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27540104/sedentary-work-and-the-risk-of-breast-cancer-in-premenopausal-and-postmenopausal-women-a-pooled-analysis-of-two-case-control-studies
#19
Terry Boyle, Lin Fritschi, Lindsay C Kobayashi, Jane S Heyworth, Derrick G Lee, Si Si, Kristan J Aronson, John J Spinelli
OBJECTIVES: There is limited research on the association between sedentary behaviour and breast cancer risk, particularly whether sedentary behaviour is differentially associated with premenopausal and postmenopausal breast cancer. We pooled data from 2 case-control studies from Australia and Canada to investigate this association. METHODS: This pooled analysis included 1762 incident breast cancer cases and 2532 controls. Participants in both studies completed a lifetime occupational history and self-rated occupational physical activity level...
November 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27540103/job-exposure-matrix-for-the-assessment-of-alkylphenolic-compounds
#20
Mayte Martín-Bustamante, Anna Oliete-Canela, Marta Diéguez-Rodríguez, Yolanda Benavente, Delphine Casabonne, Juan Alguacil, Manolis Kogevinas, Silvia de Sanjosé, Laura Costas
OBJECTIVES: Our aim was to develop a job-exposure matrix (JEM) to assess occupational exposure to alkylphenolic compounds in epidemiological research, considering changes in their use over time, and including exposure probabilities in the assessments. METHODS: We consulted multiple sources of information, and performed interviews with 9 key people from industry and academia. 3 hygienists coded frequency (minority or majority of workers involved) and intensity of exposure (including dispersive processes, with shaking, or aerosol generation, or otherwise) to alkylphenolic compounds for all the 390 International Standard Classification of Occupations (ISCO)-88 job titles by period of time...
August 18, 2016: Occupational and Environmental Medicine
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