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https://www.readbyqxmd.com/read/28910824/occupational-solvent-exposure-and-risk-of-glioma-in-the-interocc-study
#1
Geza Benke, Michelle C Turner, Sarah Fleming, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Maria Blettner, Martine Hours, Daniel Krewski, David McLean, Marie-Elise Parent, Siegal Sadetzki, Klaus Schlaefer, Brigitte Schlehofer, Jack Siemiatycki, Martie van Tongeren, Elisabeth Cardis
BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade...
September 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28910766/light-field-compression-with-disparity-guided-sparse-coding-based-on-structural-key-views
#2
Jie Chen, Junhui Hou, Lap-Pui Chau
Recent imaging technologies are rapidly evolving for sampling richer and more immersive representations of the 3D world. One of the emerging technologies is light field (LF) cameras based on micro-lens arrays. To record the directional information of the light rays, a much larger storage space and transmission bandwidth are required by a LF image as compared with a conventional 2D image of similar spatial dimension. Hence, the compression of LF data becomes a vital part of its application. In this paper, we propose a LF codec with disparity guided Sparse Coding over a learned perspective-shifted LF dictionary based on selected Structural Key Views (SC-SKV)...
September 8, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28904109/a-wound-healing-program-is-hijacked-to-promote-cancer-metastasis
#3
Leif W Ellisen
In this issue of JEM, Sundaram et al. (https://doi.org/10.1084/jem.20170354) report a mechanism by which the normal epithelial wound healing response is "hijacked" to promote invasion and metastasis in head and neck squamous carcinomas (HNSCCs), a finding that unveils new markers of poor outcomes and potential targets for therapeutic intervention.
September 13, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28841833/lifetime-occupational-exposure-to-metals-and-welding-fumes-and-risk-of-glioma-a-7-country-population-based-case-control-study
#4
Marie-Elise Parent, Michelle C Turner, Jérôme Lavoué, Hugues Richard, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Geza Benke, Maria Blettner, Sarah Fleming, Martine Hours, Daniel Krewski, David McLean, Siegal Sadetzki, Klaus Schlaefer, Brigitte Schlehofer, Joachim Schüz, Jack Siemiatycki, Martie van Tongeren, Elisabeth Cardis
BACKGROUND: Brain tumor etiology is poorly understood. Based on their ability to pass through the blood-brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsistent. METHODS: We investigated the relationship between glioma risk and occupational exposure to five metals - lead, cadmium, nickel, chromium and iron- as well as to welding fumes, using data from the seven-country INTEROCC study...
August 25, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28822706/comparison-of-real-time-pcr-nested-pcr-and-galactomannan-antigen-detection-by-enzyme-linked-immunosorbent-assay-in-sera-for-diagnosis-of-invasive-aspergillosis
#5
S Hedhili, N Baccouchi, H Souid, B Jemli, S Gargouri
Conventional methods for diagnosis of invasive aspergillosis (IA) lack sensitivity and specificity. Serological methods still have many cases of cross-reactivity. However, molecular techniques seem to arise as a rapid approach, specific and direct that could be used in the diagnosis of IA. In this study, we analyzed 88 serum samples from patients of having IA using GM-ELISA test, nested PCR with primers for the rRNA 18S of Aspergillus genus and real time PCR specific for A. fumigatus. Among the 88 samples, 64 of them had positive GM titers and 23 had positive nested PCRs; 18 of the 23 PCR-positive samples were also GM-positive...
August 16, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28814432/minimal-to-no-transfer-of-certolizumab-pegol-into-breast-milk-results-from-cradle-a-prospective-postmarketing-multicentre-pharmacokinetic-study
#6
Megan Eb Clowse, Frauke Förger, Caroline Hwang, John Thorp, Radboud Jem Dolhain, Astrid van Tubergen, Laura Shaughnessy, Jeff Simpson, Marie Teil, Nathalie Toublanc, Maggie Wang, Thomas W Hale
BACKGROUND: Women with chronic inflammatory diseases face uncertainty regarding the safety of biologics during breast feeding. CRADLE was the first industry-sponsored study to evaluate certolizumab pegol (CZP) concentrations in human breast milk and estimate average daily infant dose (ADID) of maternal CZP. METHODS: CRADLE (NCT02154425) was a pharmacokinetic study of lactating mothers receiving CZP. After ≥3 CZP doses, breast milk samples were collected across one dosing period (14 days for 200 mg every 2 weeks [Q2W]; 28 days for 400 mg every 4 weeks [Q4W])...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28783203/cumulative-occupational-mechanical-exposures-during-working-life-and-risk-of-sickness-absence-and-disability-pension-prospective-cohort-study
#7
Emil Sundstrup, Åse Marie Hansen, Erik Lykke Mortensen, Otto Melchior Poulsen, Thomas Clausen, Reiner Rugulies, Anne Møller, Lars L Andersen
Objectives The aim of this study was to determine the prospective association of cumulative mechanical exposure during working life with health-related labor market outcomes. Methods This prospective cohort study combines data from 5076 older workers (age 49-63 years) from the Copenhagen Aging and Midlife Biobank with a job exposure matrix and a national register containing information on social transfer payment. By coding individual job histories from the Danish version of ISCO-codes (International Standard Classification of Occupations), we calculated cumulative occupational mechanical exposures from a JEM for ton-years (lifting 1000 kg each day in one year), lifting-years (lifting loads weighing ≥20 kg >10 times each day in one year), kneeling-years (kneeling for one hour each day in one year) and vibration-years (whole-body vibration for one hour each day in one year)...
August 7, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28782791/occupational-exposures-to-solvents-and-metals-are-associated-with-fixed-airflow-obstruction
#8
Sheikh M Alif, Shyamali C Dharmage, Geza Benke, Martine Dennekamp, Jennifer L Burgess, Caroline J Lodge, Stephen Morrison, David P Johns, Graham G Giles, Lyle C Gurrin, Paul S Thomas, John L Hopper, Richard Wood-Baker, Bruce R Thompson, Iain H Feather, Roel Vermeulen, Hans Kromhout, E Haydn Walters, Michael J Abramson, Melanie C Matheson
Objectives This study investigated the associations between occupational exposures to solvents and metals and fixed airflow obstruction (AO) using post-bronchodilator spirometry. Methods We included 1335 participants from the 2002-2008 follow-up of the Tasmanian Longitudinal Health Study. Ever-exposure and cumulative exposure-unit (EU) years were calculated using the ALOHA plus job exposure matrix (JEM). Fixed AO was defined as post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0...
August 7, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28776822/ripple-mapping-initial-multicenter-experience-of-an-intuitive-approach-to-overcoming-the-limitations-of-3d-activation-mapping
#9
Vishal Luther, Nuno Cortez-Dias, Luís Carpinteiro, João de Sousa, Richard Balasubramaniam, Sharad Agarwal, David Farwell, Mark Sopher, Girish Babu, Richard Till, Nikki Jones, Stuart Tan, Anthony Chow, Martin Lowe, Jem Lane, Naveen Pappachan, Nicholas Linton, Prapa Kanagaratnam
BACKGROUND: Ripple mapping (RM) displays electrograms as moving bars over a three-dimensional surface displaying bipolar voltage, and has shown in a single-center series to be effective for atrial tachycardia (AT) mapping without annotation of local activation time or window-of-interest assignment. We tested the reproducibility of these findings in operators naïve to RM, using it for the first time in postablation AT. METHODS: Maps were collected with multielectrode catheters and CARTO ConfiDENSE...
August 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28774612/biomarkers-of-end-of-shift-exposure-to-disinfection-byproducts-in-nurses
#10
Solomon Ioannou, Xanthi D Andrianou, Pantelis Charisiadis, Konstantinos C Makris
Increased disinfectant use commonly takes place in hospitals and other health care settings. A cross-sectional study among active nurses in two Cypriot public hospitals (n=179) was conducted to examine the prevalence of exposure to disinfection byproducts (DBPs), such as trihalomethanes (THMs) using both self-reported information and biomarker measurements. The objectives of this study were to: i) quantify the magnitude and variability of occupational exposure to disinfectants/DBPs in nurses, ii) generate job exposure matrices (JEM) and job task exposure matrices (JTEM) for disinfectants, and iii) assess the major determinants of urinary THMs in nurses...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28766006/tissue-level-cardiac-electrophysiology-studied-in-murine-myocardium-using-a-microelectrode-array-autonomic-and-thermal-modulation
#11
Jem D Lane, David Montaigne, Andrew Tinker
Cardiac electrophysiology is regulated by the autonomic nervous system, and this has both pathophysiological, and possibly therapeutic importance. Furthermore, chamber differences in electrophysiology exist between atria and ventricles, yet there have been few direct comparisons. There is substantial literature on ion channel modulation at the single-cell level but less work on how this affects tissue-level parameters. We used a microelectrode array system to explore these issues using murine atrial and ventricular tissue slices...
August 1, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28755419/quality-assurance-in-proton-beam-therapy-using-a-plastic-scintillator-and-a-commercially-available-digital-camera
#12
Mansour Almurayshid, Yusuf Helo, Andrzej Kacperek, Jennifer Griffiths, Jem Hebden, Adam Gibson
PURPOSE: In this article, we evaluate a plastic scintillation detector system for quality assurance in proton therapy using a BC-408 plastic scintillator, a commercial camera, and a computer. METHODS: The basic characteristics of the system were assessed in a series of proton irradiations. The reproducibility and response to changes of dose, dose-rate, and proton energy were determined. Photographs of the scintillation light distributions were acquired, and compared with Geant4 Monte Carlo simulations and with depth-dose curves measured with an ionization chamber...
July 29, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28753039/occupational-exposures-and-subclinical-interstitial-lung-disease-the-multi-ethnic-study-of-atherosclerosis-mesa-air-lung-study
#13
Coralynn S Sack, Brent C Doney, Anna J Podolanczuk, Laura G Hooper, Noah S Seixas, Eric A Hoffman, Steven M Kawut, Sverre Vedal, Ganesh Raghu, R Graham Barr, David J Lederer, Joel D Kaufman
RATIONALE: The impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied. OBJECTIVE: To determine whether occupational exposures to vapors, gas, dust and fumes (VGDF) are associated with high attenuation areas (HAA) and interstitial lung abnormalities (ILA), which are quantitative and qualitative CT-based measurements of subclinical ILD, respectively. METHODS: We performed analyses of participants enrolled in MESA, a population-based cohort age 45-84 at recruitment...
July 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28747425/jem-advisory-editorial-board-increasing-diversity
#14
EDITORIAL
Carl Nathan, Michel C Nussenzweig, Teodoro Pulvirenti
No abstract text is available yet for this article.
July 26, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28725621/chemical-composition-acute-toxicity-antioxidant-and-anti-inflammatory-activities-of-moroccan-tetraclinis-articulata-l
#15
Meryem El Jemli, Rabie Kamal, Ilias Marmouzi, Zouhra Doukkali, El Houcine Bouidida, Driss Touati, Rachid Nejjari, Lahcen El Guessabi, Yahia Cherrah, Katim Alaoui
Hydro-distilled essential oil (EO) from the leaves of the western Mediterranean and Moroccan endemic plant Tetraclinis articulata was analyzed by GC/MS and examined for its acute toxicity on mice, in order to establish the safe doses. Furthermore, the anti-Inflammatory activity was evaluated based on carrageenan and trauma induced rats paw edema and the antioxidant potential has been investigated using different methods including DPPH radical-scavenging assay, Trolox equivalent antioxidant capacity (TEAC) and Ferric-reducing antioxidant power assay (FRAP)...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28704227/mortality-among-hardmetal-production-workers-occupational-exposures
#16
Kathleen J Kennedy, Nurtan A Esmen, Jeanine M Buchanich, Sarah Zimmerman, Anne J Sleeuwenhoek, Gary M Marsh
OBJECTIVE: To generate quantitative exposure estimates for use in retrospective occupational cohort mortality studies of the hardmetal industry. METHODS: Job-exposure matrices (JEMs) were constructed for cobalt, tungsten, and nickel over the time period 1952 to 2014. The JEMs consisted of job class categories, based on job titles and processes performed, and exposure estimates calculated from available company industrial hygiene measurements. RESULTS: Exposure intervals of one-half order magnitude were established for all three agents...
July 12, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28688618/nonlinear-integral-sliding-mode-control-design-of-photovoltaic-pumping-system-real-time-implementation
#17
Asma Chihi, Hechmi Ben Azza, Mohamed Jemli, Anis Sellami
The aim of this paper is to provide high performance control of pumping system. The proposed method is designed by an indirect field oriented control based on Sliding Mode (SM) technique. The first contribution of this work is to design modified switching surfaces which presented by adding an integral action to the considered controlled variables. Then, in order to prevent the chattering phenomenon, modified nonlinear component is developed. The SM concept and a Lyapunov function are combined to compute the Sliding Mode Control (SMC) gains...
July 5, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28652305/regulation-of-brain-insulin-signaling-a-new-function-for-tau
#18
Maud Gratuze, Emmanuel Planel
In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the brain. They find that tau deletion impairs hippocampal response to insulin through IRS-1 and PTEN dysregulation and suggest that, in Alzheimer's disease, impairment of brain insulin signaling might occur via tau loss of function.
August 7, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28600993/robust-sensitive-and-facile-method-for-detection-of-f-cn-and-ac-anions
#19
P Madhusudhana Reddy, Shih-Rong Hsieh, Jem-Kun Chen, Chi-Jung Chang, Jing-Yuan Kang, Chih-Hsien Chen
Sensing of F(-), CN(-) and Ac(-) is important from the viewpoint of both medically and environmentally. Particularly, sensing of the anions in 100% water by a colorimetric chemical sensor is a highly difficult task as water molecules interfere the sensing mechanism. In this regard, sensor R1, having azo and nitrophenyl groups as signaling units and thiourea as a binding site was prepared. This sensor exclusively detected CN(-) ion over other testing anions in 30% aq. DMSO solution by exhibiting distinct spectral and visual color changes...
June 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28571111/occupational-solvent-exposure-and-adult-chronic-lymphocytic-leukemia-no-risk-in-a-population-based-case-control-study-in-four-nordic-countries
#20
Madar Talibov, Anssi Auvinen, Elisabete Weiderpass, Johnni Hansen, Jan-Ivar Martinsen, Kristina Kjaerheim, Laufey Tryggvadottir, Eero Pukkala
The aim of this study was to assess the effect of occupational solvent exposure on the risk of adult chronic lymphocytic leukemia (CLL). The current case-control study was nested in the Nordic Occupational Cancer Study (NOCCA) cohort. 20,615 CLL cases diagnosed in 1961-2005 in Finland, Iceland, Norway, and Sweden, and 103,075 population-based controls matched by year of birth, sex, and country were included. Occupational histories for cases and controls were obtained from census records in 1960, 1970, 1980/1981, and 1990...
June 1, 2017: International Journal of Cancer. Journal International du Cancer
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