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https://www.readbyqxmd.com/read/28214204/detection-of-occult-endocervical-glandular-dysplasia-in-cervical-conization-specimens-for-squamous-lesions
#1
F Sopracordevole, N Clemente, L Alessandrini, J Di Giuseppe, F Cigolot, M Buttignol, A Ciavattini, V Canzonieri
The aim of this work was to evaluate the incidence of occult cervical glandular intraepithelial neoplasia (CGIN) and adenocarcinoma of the cervix (AC) in women treated with CO2-laser conization for cervical intraepithelial neoplasia (CIN) or squamocellular cervical cancer (SCC). The medical records of all women with a histological diagnosis of squamous lesions of the uterine cervix (persistent CIN1, CIN2, CIN3 and SCC) who were subsequently treated with CO2-laser conization at our institution, during the period from January 1991 to December 2014, were analyzed in a retrospective case series...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28174190/unusual-sites-of-metastases-of-carcinoma-cervix
#2
Renitha Miriam Cherian, Jenifer Jeba, Sramana Mukhopadhyay, Selvamani Backianathan
We present a case of metastatic squamous cell carcinoma cervix with solitary bone metastases to the right tibia and multiple cutaneous metastases. A woman aged 52 years with cancer of the cervix and lung metastases, after 21 months of initial diagnosis and palliative chemotherapy presented with pain in the right knee and multiple nodular skin lesions. Bone scintigraphy revealed intense increased tracer activity in the proximal and mid shaft of the right tibia. Biopsy from the tibial lesion confirmed metastatic squamous cell carcinoma...
February 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28166075/clinico-histopathological-survey-of-head-and-neck-cancer-at-tertiary-health-care-centre-dhulikhel-hospital
#3
S Dixit, C Upadhyaya, M Humagain, R Srii, V Marla
Background Head and neck is one of the most prevalent site for cancers along with lungs, cervix, breast and stomach. Hospital based cancer registries required for effective evaluation of diagnosis and management of cancer is inadequate in Nepal. Cancer registry system established by WHO is acquired by seven major hospitals in our country. However, data from tertiary health care centres like ours remain undocumented. Objective The objective of this study is to perform retrospective analysis of clinicohistopathological types of head and neck lesions which were eventually diagnosed as cancer in Dhulikel Hospital, a tertiary health care centre of Central East Nepal...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28124469/lichen-sclerosus-and-risk-of-cancer
#4
Pia M Halonen, Maija I Jakobsson, M A Oskari Heikinheimo, Annika E Riska, Mika V Gissler, Eero I Pukkala
Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection. We identified all women with the diagnosis of LS (n= 7,616) listed in the Finnish Hospital Discharge Registry from 1970-2012. The cohort was followed through the Finnish Cancer Registry for subsequent cancer diagnoses until 2014. Standardized Incidence Ratios (SIRs) were calculated for different cancers by dividing the observed numbers of cancers by expected ones...
January 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28122528/a-non-invasive-tool-for-detecting-cervical-cancer-odor-by-trained-scent-dogs
#5
Héctor Guerrero-Flores, Teresa Apresa-García, Ónix Garay-Villar, Alejandro Sánchez-Pérez, David Flores-Villegas, Artfy Bandera-Calderón, Raúl García-Palacios, Teresita Rojas-Sánchez, Pablo Romero-Morelos, Verónica Sánchez-Albor, Osvaldo Mata, Víctor Arana-Conejo, Jesús Badillo-Romero, Keiko Taniguchi, Daniel Marrero-Rodríguez, Mónica Mendoza-Rodríguez, Miriam Rodríguez-Esquivel, Víctor Huerta-Padilla, Andrea Martínez-Castillo, Irma Hernández-Gallardo, Ricardo López-Romero, Cindy Bandala, Juan Rosales-Guevara, Mauricio Salcedo
BACKGROUND: Cervical Cancer (CC) has become a public health concern of alarming proportions in many developing countries such as Mexico, particularly in low income sectors and marginalized regions. As such, an early detection is a key medical factor in improving not only their population's quality of life but also its life expectancy. Interestingly, there has been an increase in the number of reports describing successful attempts at detecting cancer cells in human tissues or fluids using trained (sniffer) dogs...
January 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28116194/endocervical-carcinogenesis-and-hpv-vaccination-an-occasional-circumstance-or-a-gap-in-the-chain
#6
Georgios-Marios Makris, Petros Karakitsos, Eugenia Kotsifa, Niki Margari, Nikiforita Poulakaki, Theodoros N Sergentanis, Marco-Johannes Battista, Charalampos Chrelias, Nicolaos Papantoniou
As a result of the Human Papillomavirus (HPV) vaccination program, the prevalence of precancerous dysplasia and invasive cervical cancer has substantially decreased. In this brief report, we present a case of a young patient who was diagnosed with in situ adenocarcinoma of the cervix. This 30-year-old female had completed the HPV vaccination after she became sexually active and has been undergoing annual gynecological assessments, including clinical examination and Pap test, all of which had been negative. This year, her Pap test revealed a low grade squamous intraepithelial lesion (LGSIL) and additionally a colposcopy was performed...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28115961/encrusted-cystitis-after-definitive-radiotherapy-for-cervical-cancer-a-case-report
#7
Elisabetta Perrucci, Valentina Lancellotta, Maika di Benedetto, Isabella Palumbo, Fabio Matrone, Marino Chiodi, Riccardo Lombi, Marta Marcantonini, Cristina Mariucci, Cynthia Aristei
PURPOSE: Encrusted cystitis is a rare chronic inflammatory disease characterized by calcified plaques of the bladder, previously altered by varies conditions as urological procedures, caused by urea-splitting bacteria. Only one case has been reported on encrusted cystitis occurring after surgery and radiation therapy for a pelvic neoplasm. We report on encrusted cystitis occurred after definitive radiotherapy for bulky uterine cervix cancer, and examine the doses to the bladder wall and the procedure of radiation treatment performed as a possible cause of the onset of the disease...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28114406/identification-of-hpv-types-and-mycobacterium-tuberculosis-complex-in-historical-long-term-preserved-formalin-fixed-tissues-in-different-human-organs
#8
Maja Hühns, Andreas Erbersdobler, Annette Obliers, Paula Röpenack
University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis...
2017: PloS One
https://www.readbyqxmd.com/read/28108997/risk-of-high-grade-precancerous-lesions-and-invasive-cancers-in-high-risk-hpv-positive-women-with-normal-cervix-or-cin-1-at-baseline-a-population-based-cohort-study
#9
Srabani Mittal, Partha Basu, Richard Muwonge, Dipanwita Banerjee, Ishita Ghosh, Mitali Mukherjee Sengupta, Pradip Das, Priatosh Dey, Ranajit Mandal, Chinmay Panda, Jaydip Biswas, Rengaswamy Sankaranarayanan
Infection with high-risk human papillomavirus (HR-HPV) is transient and clears on its own in majority of the women. Only a few women who have persistent infection may finally develop cervical intraepithelial neoplasia (CIN) or cervical cancer in later years. The risk of progression in the HR-HPV-positive women with normal cervix or low-grade lesion on colposcopy and histopathology at baseline is less studied. We performed a longitudinal study on 650 HR-HPV-positive women with colposcopy and/or histopathology-proved normal or CIN1 diagnosis at baseline to assess the cumulative risk of development of high-grade CIN...
January 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28101801/identification-of-changes-in-the-human-papilloma-virus-16-hpv16-genome-during-early-dissemination-of-cervical-cancer-cells-may-complement-histological-diagnosis-of-lymph-node-metastasis
#10
Anirban Roychowdhury, Sudip Samadder, Md Saimul Islam, Kalyansree Chaudhury, Anup Roy, Dipanwita Banerjee, Ranajit Mandal, Partha S Basu, Susanta Roychoudhury, Chinmay Kumar Panda
Cancer of the uterine cervix (CACX) is one of the most common carcinoma affecting women worldwide. During treatment, histologically lymph node (LN) metastasis and presence of HPV DNA in blood plasma act as a major prognostic factor. Despite the lack of apparent LN involvement, some early-invasive CACX patients have shown recurrences and poor survival. This is suggestive of undetected early dissemination of cancer cells characterized by presence of HPV DNA in histologically non-metastatic LNs which finally progresses into histologically visible metastasis...
January 19, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28101349/clear-cell-carcinoma-of-the-lower-uterine-segment-a-case-report
#11
Yusuke Matoba, Iori Kisu, Keiko Saotome, Motoko Katayama, Makiko Taniguchi, Yumiko Miura, Taeko Goto, Nobumaru Hirao
Uterine carcinoma of the lower uterine segment (LUS) is a rare tumor that accounts for 3-3.5% of cases of uterine malignant cancer. The tumor arises from the lower region of the uterine body through the upper region of the cervix. The present study reported a case of clear cell carcinoma that originated from the LUS. A 50-year-old woman visited a local hospital due to irregular vaginal bleeding. She was suspected to have a uterine tumor and was referred to Tachikawa Hospital (Tokyo, Japan). Transvaginal ultrasound and magnetic resonance imaging revealed a uterine tumor from the lower region of the uterine body through the upper region of the cervix...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28035489/the-association-between-a-history-of-gestational-diabetes-mellitus-and-future-risk-for-female-malignancies
#12
Oded Fuchs, Eyal Sheiner, Mihai Meirovitz, Ehud Davidson, Ruslan Sergienko, Roy Kessous
OBJECTIVE: To investigate whether patients with a history of gestational diabetes mellitus (GDM) have an increased future risk for female malignancies. STUDY DESIGN: A population-based study compared the incidence of long-term female malignancies (ovary, uterine, breast, and uterine cervix) in a cohort of women with and without a diagnosis of GDM. Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12 years. Women with known malignancies prior to the index pregnancy were excluded...
March 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28028296/human-papillomavirus-hpv-in-egyptian-females-study-by-cytology-histopathology-colposcopy-and-molecular-diagnosis-of-high-risk-types
#13
M A Nayel, O G Shaker, A N Hosni, H N Hosni, S E Khalifa, A F Shazly
OBJECTIVES: In Northern Africa, the region Egypt belongs to, about 10.7% of women are estimated to harbour cervical human papillomavirus (HPV) infection and 78.4% of invasive cancers are attributed to HPVs 16 or 18. We aimed at comparing HPV detection by ISH-PCR tissue with other conventional available cheaper techniques, finding which of them can be relied upon in a developing country like Egypt for HPV detection. METHODS: Sixty patients were included. For them colposcopy, PAP smear, histopathology and detection of HPV using ISH PCR tissue and PCR swab were achieved...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28012795/determining-the-need-and-utilization-of-radiotherapy-in-cancers-of-the-breast-cervix-lung-prostate-and-rectum-a-population-level-study
#14
Lorraine Shack, Shuang Lu, Lee-Anne Weeks, Peter Craighead, Marc Kerba
PURPOSE: Determining the appropriate rate of radiotherapy (RT) utilization is important for health care planning and resource allocation. The difference between the observed and the appropriate RT rate is influenced by the choice of a criterion based benchmarking (CBB) or evidence-based estimates (EBEST) measure. Our primary objective was to determine the utilization of radiotherapy for cancers of the breast (B), cervix (C), lung (L), prostate (P) and rectum (R) in Alberta (AB) Canada and to compare the observed RT rates to estimates of need derived from the criterion based benchmarking (CBB) and evidence-based estimates (EBEST)...
January 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28002209/value-of-specialist-pathology-review-in-a-single-statewide-gynecologic-cancer-service
#15
Jerome Melon, Yee Leung, Stuart G Salfinger, Jason Tan, Ganendra Mohan, Paul A Cohen
OBJECTIVE: A case review by specialist diagnostic pathologists as part of a Gynecologic Oncology Multi-disciplinary Tumor group has the potential to influence the management of patients with cancer. The primary aim of this study was to determine the frequency of diagnostic discrepancies between the initial (nonspecialist) and final pathological diagnoses in cases referred to the Gynecologic Oncology Tumor Conference (TC) in Western Australia and the impact of such revised diagnosis on clinical management...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27995101/a-comparison-of-liquid-based-cytology-with-conventional-papanicolaou-smears-in-cervical-dysplasia-diagnosis
#16
Fatemeh Haghighi, Nahid Ghanbarzadeh, Marziee Ataee, Gholamreza Sharifzadeh, Javid Shahbazi Mojarrad, Fatemeh Najafi-Semnani
BACKGROUND: Due to the high number of women affected by cervical cancer and the importance of an early diagnosis, combined with the frequent incidence of false-negative Papanicolaou (Pap) smear screening results for this disease, several studies have been conducted in recent years in order to find better tests. Liquid-based cytology (LBC) tests, including the liquid-based thin layer method, have demonstrated the highest potential for reducing false-negative cases and improved sample quality...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27960241/the-changing-landscape-of-gynaecological-cancer-diagnosis-implications-for-histopathological-practice-in-the-21st-century
#17
REVIEW
Naveena Singh, C Blake Gilks
The era of molecular medicine has led to dramatically improved understanding of the genetic events that give rise to different types of cancers. In the case of gynaecological malignancies, this has resulted in distinct shifts in how these tumours are diagnosed in routine surgical pathology practice, with an increased emphasis on accurate subtype diagnosis. This has happened across all sites in the gynaecological tract and for most cell types, but in ways that are site-specific and may appear to be subtle, as in most instances the diagnostic terminology has not changed...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27917295/circulating-human-papillomavirus-dna-detected-using-droplet-digital-pcr-in-the-serum-of-patients-diagnosed-with-early-stage-human-papillomavirus-associated-invasive-carcinoma
#18
Emmanuelle Jeannot, Véronique Becette, Maura Campitelli, Marie-Ange Calméjane, Emmanuelle Lappartient, Evelyne Ruff, Stéphanie Saada, Allyson Holmes, Dominique Bellet, Xavier Sastre-Garau
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours. Here we took advantage of the sensitive droplet digital PCR method to identify circulating human papillomavirus DNA in patients with human papillomavirus-associated carcinomas...
October 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27914156/-intratechal-chemotherapy-treatment-through-an-ommaya-reservoir-catheter-for-meningeal-carcinomatosis-a-single-centre-experience
#19
José Pedro Lavrador, Nuno Simas, Edson Oliveira, Manuel Herculano Carvalho
INTRODUCTION: Meningeal carcinomatosis is defined as tumour cells infiltration of leptomeninges and subarachnoid space. It is normally related with poor survival (2 - 5 months). The best multidisciplinary treatment for this condition is a matter of discussion. Patient's condition and the natural history of the disease should be considered in the decision making process. MATERIAL AND METHODS: Retrospective cohort analysis of patients submitted to Ommaya Reservoir placement due to systemic solid tumour meningeal carcinomatosis between 2006 and 2014...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27900204/preoperative-mr-staging-of-cervical-carcinoma-are-oblique-and-contrast-enhanced-sequences-necessary
#20
Susanne Fridsten, Ann-Cathrin Hellström, Kristina Hellman, Anders Sundin, Boel Söderén, Lennart Blomqvist
BACKGROUND: As the choice of treatment in patients with cervical carcinoma depends on cancer stage at diagnosis, accurate staging is essential. PURPOSE: To compare three different combinations of magnetic resonance (MR) sequences for preoperative staging. MATERIAL AND METHODS: Fifty-seven consecutive patients with biopsy proven cervical carcinoma underwent MR imaging (MRI) staging followed by primary surgical treatment. Thirty-two of 57 patients had had a cone biopsy prior to MRI...
November 2016: Acta Radiologica Open
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