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https://www.readbyqxmd.com/read/28108997/risk-of-high-grade-precancerous-lesions-and-invasive-cancers-in-high-risk-hpv-positive-women-with-normal-cervix-or-cin-1-at-baseline-a-population-based-cohort-study
#1
Srabani Mittal, Partha Basu, Richard Muwonge, Dipanwita Banerjee, Ishita Ghosh, Mitali Mukherjee Sengupta, Pradip Das, Priatosh Dey, Ranajit Mandal, Chinmay Panda, Jaydip Biswas, Rengaswamy Sankaranarayanan
Infection with High-risk Human Papillomavirus (HR-HPV) is transient and clears on its own in majority of the women. Only a few women who have persistent infection may finally develop Cervical Intraepithelial Neoplasia (CIN) or cervical cancer in later years. The risk of progression in the HR-HPV positive women with normal cervix or low grade lesion on colposcopy and histopathology at baseline is less studied. We performed a longitudinal study on 650 HR-HPV positive women with colposcopy and/or histopathology proved normal or CIN1 diagnosis at baselineto assess the cumulative risk of development of high-grade CIN...
January 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28101801/identification-of-changes-in-the-human-papilloma-virus-16-hpv16-genome-during-early-dissemination-of-cervical-cancer-cells-may-complement-histological-diagnosis-of-lymph-node-metastasis
#2
Anirban Roychowdhury, Sudip Samadder, Md Saimul Islam, Kalyansree Chaudhury, Anup Roy, Dipanwita Banerjee, Ranajit Mandal, Partha S Basu, Susanta Roychoudhury, Chinmay Kumar Panda
Cancer of the uterine cervix (CACX) is one of the most common carcinoma affecting women worldwide. During treatment, histologically lymph node (LN) metastasis and presence of HPV DNA in blood plasma act as a major prognostic factor. Despite the lack of apparent LN involvement, some early-invasive CACX patients have shown recurrences and poor survival. This is suggestive of undetected early dissemination of cancer cells characterized by presence of HPV DNA in histologically non-metastatic LNs which finally progresses into histologically visible metastasis...
January 19, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28101349/clear-cell-carcinoma-of-the-lower-uterine-segment-a-case-report
#3
Yusuke Matoba, Iori Kisu, Keiko Saotome, Motoko Katayama, Makiko Taniguchi, Yumiko Miura, Taeko Goto, Nobumaru Hirao
Uterine carcinoma of the lower uterine segment (LUS) is a rare tumor that accounts for 3-3.5% of cases of uterine malignant cancer. The tumor arises from the lower region of the uterine body through the upper region of the cervix. The present study reported a case of clear cell carcinoma that originated from the LUS. A 50-year-old woman visited a local hospital due to irregular vaginal bleeding. She was suspected to have a uterine tumor and was referred to Tachikawa Hospital (Tokyo, Japan). Transvaginal ultrasound and magnetic resonance imaging revealed a uterine tumor from the lower region of the uterine body through the upper region of the cervix...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28035489/the-association-between-a-history-of-gestational-diabetes-mellitus-and-future-risk-for-female-malignancies
#4
Oded Fuchs, Eyal Sheiner, Mihai Meirovitz, Ehud Davidson, Ruslan Sergienko, Roy Kessous
OBJECTIVE: To investigate whether patients with a history of gestational diabetes mellitus (GDM) have an increased future risk for female malignancies. STUDY DESIGN: A population-based study compared the incidence of long-term female malignancies (ovary, uterine, breast, and uterine cervix) in a cohort of women with and without a diagnosis of GDM. Deliveries occurred between the years 1988-2013, with a mean follow-up duration of 12 years. Women with known malignancies prior to the index pregnancy were excluded...
December 29, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28028296/human-papillomavirus-hpv-in-egyptian-females-study-by-cytology-histopathology-colposcopy-and-molecular-diagnosis-of-high-risk-types
#5
M A Nayel, O G Shaker, A N Hosni, H N Hosni, S E Khalifa, A F Shazly
OBJECTIVES: In Northern Africa, the region Egypt belongs to, about 10.7% of women are estimated to harbour cervical human papillomavirus (HPV) infection and 78.4% of invasive cancers are attributed to HPVs 16 or 18. We aimed at comparing HPV detection by ISH-PCR tissue with other conventional available cheaper techniques, finding which of them can be relied upon in a developing country like Egypt for HPV detection. METHODS: Sixty patients were included. For them colposcopy, PAP smear, histopathology and detection of HPV using ISH PCR tissue and PCR swab were achieved...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28012795/determining-the-need-and-utilization-of-radiotherapy-in-cancers-of-the-breast-cervical-lung-prostate-and-rectum-a-population-level-study
#6
Lorraine Shack, Shuang Lu, Lee-Anne Weeks, Peter Craighead, Marc Kerba
PURPOSE: Determining the appropriate rate of radiotherapy (RT) utilization is important for health care planning and resource allocation. The difference between the observed and the appropriate RT rate is influenced by the choice of a criterion based benchmarking (CBB) or evidence-based estimates (EBEST) measure. Our primary objective was to determine the utilization of radiotherapy for cancers of the breast (B), cervix (C), lung (L), prostate (P) and rectum (R) in Alberta (AB) Canada and to compare the observed RT rates to estimates of need derived from the criterion based benchmarking (CBB) and evidence-based estimates (EBEST)...
December 21, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28002209/value-of-specialist-pathology-review-in-a-single-statewide-gynecologic-cancer-service
#7
Jerome Melon, Yee Leung, Stuart G Salfinger, Jason Tan, Ganendra Mohan, Paul A Cohen
OBJECTIVE: A case review by specialist diagnostic pathologists as part of a Gynecologic Oncology Multi-disciplinary Tumor group has the potential to influence the management of patients with cancer. The primary aim of this study was to determine the frequency of diagnostic discrepancies between the initial (nonspecialist) and final pathological diagnoses in cases referred to the Gynecologic Oncology Tumor Conference (TC) in Western Australia and the impact of such revised diagnosis on clinical management...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27995101/a-comparison-of-liquid-based-cytology-with-conventional-papanicolaou-smears-in-cervical-dysplasia-diagnosis
#8
Fatemeh Haghighi, Nahid Ghanbarzadeh, Marziee Ataee, Gholamreza Sharifzadeh, Javid Shahbazi Mojarrad, Fatemeh Najafi-Semnani
BACKGROUND: Due to the high number of women affected by cervical cancer and the importance of an early diagnosis, combined with the frequent incidence of false-negative Papanicolaou (Pap) smear screening results for this disease, several studies have been conducted in recent years in order to find better tests. Liquid-based cytology (LBC) tests, including the liquid-based thin layer method, have demonstrated the highest potential for reducing false-negative cases and improved sample quality...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27960241/the-changing-landscape-of-gynaecological-cancer-diagnosis-implications-for-histopathological-practice-in-the-21st-century
#9
REVIEW
Naveena Singh, C Blake Gilks
The era of molecular medicine has led to dramatically improved understanding of the genetic events that give rise to different types of cancers. In the case of gynaecological malignancies, this has resulted in distinct shifts in how these tumours are diagnosed in routine surgical pathology practice, with an increased emphasis on accurate subtype diagnosis. This has happened across all sites in the gynaecological tract and for most cell types, but in ways that are site-specific and may appear to be subtle, as in most instances the diagnostic terminology has not changed...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27917295/circulating-human-papillomavirus-dna-detected-using-droplet-digital-pcr-in-the-serum-of-patients-diagnosed-with-early-stage-human-papillomavirus-associated-invasive-carcinoma
#10
Emmanuelle Jeannot, Véronique Becette, Maura Campitelli, Marie-Ange Calméjane, Emmanuelle Lappartient, Evelyne Ruff, Stéphanie Saada, Allyson Holmes, Dominique Bellet, Xavier Sastre-Garau
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours. Here we took advantage of the sensitive droplet digital PCR method to identify circulating human papillomavirus DNA in patients with human papillomavirus-associated carcinomas...
October 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27914156/-intratechal-chemotherapy-treatment-through-an-ommaya-reservoir-catheter-for-meningeal-carcinomatosis-a-single-centre-experience
#11
José Pedro Lavrador, Nuno Simas, Edson Oliveira, Manuel Herculano Carvalho
INTRODUCTION: Meningeal carcinomatosis is defined as tumour cells infiltration of leptomeninges and subarachnoid space. It is normally related with poor survival (2 - 5 months). The best multidisciplinary treatment for this condition is a matter of discussion. Patient's condition and the natural history of the disease should be considered in the decision making process. MATERIAL AND METHODS: Retrospective cohort analysis of patients submitted to Ommaya Reservoir placement due to systemic solid tumour meningeal carcinomatosis between 2006 and 2014...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27900204/preoperative-mr-staging-of-cervical-carcinoma-are-oblique-and-contrast-enhanced-sequences-necessary
#12
Susanne Fridsten, Ann-Cathrin Hellström, Kristina Hellman, Anders Sundin, Boel Söderén, Lennart Blomqvist
BACKGROUND: As the choice of treatment in patients with cervical carcinoma depends on cancer stage at diagnosis, accurate staging is essential. PURPOSE: To compare three different combinations of magnetic resonance (MR) sequences for preoperative staging. MATERIAL AND METHODS: Fifty-seven consecutive patients with biopsy proven cervical carcinoma underwent MR imaging (MRI) staging followed by primary surgical treatment. Thirty-two of 57 patients had had a cone biopsy prior to MRI...
November 2016: Acta Radiologica Open
https://www.readbyqxmd.com/read/27886713/automated-classification-of-pap-smear-images-to-detect-cervical-dysplasia
#13
Kangkana Bora, Manish Chowdhury, Lipi B Mahanta, Malay Kumar Kundu, Anup Kumar Das
BACKGROUND AND OBJECTIVES: The present study proposes an intelligent system for automatic categorization of Pap smear images to detect cervical dysplasia, which has been an open problem ongoing for last five decades. METHODS: The classification technique is based on shape, texture and color features. It classifies the cervical dysplasia into two-level (normal and abnormal) and three-level (Negative for Intraepithelial Lesion or Malignancy, Low-grade Squamous Intraepithelial Lesion and High-grade Squamous Intraepithelial Lesion) classes reflecting the established Bethesda system of classification used for diagnosis of cancerous or precancerous lesion of cervix...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27870056/cure-of-cancer-for-seven-cancer-sites-in-the-flemish-region
#14
Geert Silversmit, David Jegou, Evelien Vaes, Elke Van Hoof, Els Goetghebeur, Liesbet Van Eycken
Cumulative relative survival curves for many cancers reach a plateau several years after diagnosis, indicating that the cancer survivor group has reached "statistical" cure. Parametric mixture cure model analysis on grouped relative survival curves provide an interesting way to determine the proportion of statistically cured cases and the mean survival time of the fatal cases in particular for population-based cancer registries. Based on the relative survival data from the Belgian Cancer Registry, parametric cure models were applied to seven cancer sites (cervix, colon, corpus uteri, skin melanoma, pancreas, stomach and oesophagus), at the Flemish Regional level for the incidence period 1999-2011...
March 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27837120/recommendations-for-high-risk-clinical-target-volume-definition-with-computed-tomography-for-three-dimensional-image-guided-brachytherapy-in-cervical-cancer-patients
#15
Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Li, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-Ei Noda, Tomoko Kazumoto, Yoko Harima
Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology initiated guideline development for CT-based CTVHR (based on a comprehensive literature review as well as clinical experience) in July 2014. Extensive discussions occurred during four face-to-face meetings and frequent email communication until a consensus was reached...
November 10, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27832048/vital-signs-disparities-in-tobacco-related-cancer-incidence-and-mortality-united-states-2004-2013
#16
S Jane Henley, Cheryll C Thomas, Saida R Sharapova, Behnoosh Momin, Greta M Massetti, Deborah M Winn, Brian S Armour, Lisa C Richardson
BACKGROUND: Tobacco use causes at least 12 types of cancer and is the leading preventable cause of cancer. METHODS: Data from the United States Cancer Statistics dataset for 2004-2013 were used to assess incidence and death rates and trends for cancers that can be caused by tobacco use (tobacco-related cancers: oral cavity and pharynx; esophagus; stomach; colon and rectum; liver; pancreas; larynx; lung, bronchus, and trachea; kidney and renal pelvis; urinary bladder; cervix; and acute myeloid leukemia) by sex, age, race, ethnicity, state, county-level poverty and educational attainment, and cancer site...
November 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27831506/causes-of-death-among-cancer-patients
#17
N G Zaorsky, T M Churilla, B L Egleston, S G Fisher, J A Ridge, E M Horwitz, Je Meyer Md
BACKGROUND: The purpose of our study was to characterize the causes of death among cancer patients as a function of objectives: (I) calendar year, (II) patient age, and (III) time after diagnosis. PATIENTS AND METHODS: US death certificate data in SEER Stat 8.2.1 were used to categorize cancer patient death as being due to index-cancer, non-index-cancer, and non-cancer cause from 1973 to 2012. In addition, data were characterized with standardized mortality ratios (SMRs), which provide the relative risk of death compared to all persons...
November 9, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27771166/survival-of-women-with-mullerian-adenosarcoma-a-national-cancer-data-base-study
#18
Brandon-Luke L Seagle, Margaux Kanis, Anna E Strohl, Shohreh Shahabi
OBJECTIVE: To determine overall survival (OS) and factors associated with OS of women with Mullerian adenosarcoma. METHODS: Women with adenosarcoma of the uterus, cervix or ovary (n=2205) were identified from the 1998-2011 National Cancer Data Base. Kaplan-Meier and multivariate Cox proportional-hazards survival analyses were performed to test for associations of potential explanatory variables with OS. A subset analysis of women with uterine adenosarcoma was also performed...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27769619/synthesis-and-cytotoxicity-study-of-novel-3-triazolyl-coumarins-based-fluorescent-scaffolds
#19
Sohini Sinha, Anuja Plavuvalapil Kumaran, Debasish Mishra, Priyankar Paira
Recently a choice of fluorescent bioimaging probes have been developed as medical diagnostic tools. Herein, we have introduced a series of coumarin-based target specific probes for cancer theranostic application which play a dual role in the field of both diagnosis and therapy. A fluorogenic version of 1,3-dipolar cycloaddition between azides and alkynes (DBCO) has been introduced to develop the triazolylcoumarin based fluorescent scaffolds. These scaffolds were screened for their anticancer activity against breast cancer (MCF7) and human epitheloid cervix carcinoma (HeLa) cell line...
November 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27759820/disparities-in-cancer-epidemiology-and-care-delivery-among-brazilian-indigenous-populations
#20
Pedro Nazareth Aguiar, Gustavo Trautman Stock, Gilberto de Lima Lopes, Michelle Samora de Almeida, Hakaru Tadokoro, Bárbara de Souza Gutierres, Douglas Antônio Rodrigues
Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included...
July 2016: Einstein
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